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Artificial Intelligence (4625) Natural Language Processing (1251) Substance Abuse (656) Chatbots and Conversational Agents (1150) Generative Language Models Including ChatGPT (1455) Harm Reduction Approaches (55)

Published on in Vol 27 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/66220, first published .
Pills, syringe, and medical document on a desk near a laptop

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Authors of this article:

Sudeshna Das1 Author Orcid Image ;   Yao Ge1 Author Orcid Image ;   Yuting Guo1 Author Orcid Image ;   Swati Rajwal2 Author Orcid Image ;   JaMor Hairston1 Author Orcid Image ;   Jeanne Powell1 Author Orcid Image ;   Drew Walker1 Author Orcid Image ;   Snigdha Peddireddy3 Author Orcid Image ;   Sahithi Lakamana1 Author Orcid Image ;   Selen Bozkurt1 Author Orcid Image ;   Matthew Reyna1 Author Orcid Image ;   Reza Sameni1, 4 Author Orcid Image ;   Yunyu Xiao5 Author Orcid Image ;   Sangmi Kim6 Author Orcid Image ;   Rasheeta Chandler6 Author Orcid Image ;   Natalie Hernandez7 Author Orcid Image ;   Danielle Mowery8 Author Orcid Image ;   Rachel Wightman9 Author Orcid Image ;   Jennifer Love10 Author Orcid Image ;   Anthony Spadaro11 Author Orcid Image ;   Jeanmarie Perrone12 Author Orcid Image ;   Abeed Sarker1, 4 Author Orcid Image
Article Authors Cited by (19) Tweetations (8) Metrics

Journals

  1. Wang Y, Wan Y, Lei X, Chen Q, Hu H. A retrieval augmented generation based optimization approach for medical knowledge understanding and reasoning in large language models. Array 2025;28:100504 View
  2. Parameswaran V, Bernard J, Bernard A, Deo N, Tsung S, Lyytinen K, Sharp C, Rodriguez F, Maron D, Dash R. Evaluating Large Language Models and Retrieval-Augmented Generation Enhancement for Delivering Guideline-Adherent Nutrition Information for Cardiovascular Disease Prevention: Cross-Sectional Study. Journal of Medical Internet Research 2025;27:e78625 View
  3. Sorour S, Almusallam N. L3D-RAG: Leveraging LLaMA 3.1 and DeepSeek with Retrieval-Augmented Generation (RAG) for advanced Reddit community analysis. Alexandria Engineering Journal 2025;131:125 View
  4. Abo El-Enen M, Saad S, Nazmy T. A survey on retrieval-augmentation generation (RAG) models for healthcare applications. Neural Computing and Applications 2025 View
  5. Baur D, Ansorg J, Heyde C, Voelker A. Development and Evaluation of a Retrieval-Augmented Generation Chatbot for Orthopedic and Trauma Surgery Patient Education: Mixed-Methods Study. JMIR AI 2025;4:e75262 View
  6. Walker A, Leung J, Alagappan A, Rajwal S, Lakamana S, Park T, Le N, Irani A, Sarker A, Falasinnu T, Bozkurt S. Centering Patient Voices in Lupus Pain: A Biopsychosocial Analysis of Reddit Narratives Using Large Language Models. Arthritis Care & Research 2026;78(1):123 View
  7. Fedorov A, Datyev I, Vishnyakov I. The Method for Integrating Large Language Models into Algorithms for Focused Monitoring of Open Social Media Data. Informatics and Automation 2025;24(6):1623 View
  8. Gill R, Kuzminykh I, Salem M, Ghita B. Generative AI-enabled adaptive learning platform: How I can help you pass your driving test?. Artificial Intelligence in Education 2026;2(1):1 View
  9. Makino M, She W, Siriaraya P, Matoba S, Senoo K. Evaluating the appropriateness and safety of generative AI in delivering lifestyle guidance for atrial fibrillation patients. Scientific Reports 2025;16(1) View
  10. Daglarli E. Drug and Dosage Recommendation Based on Explainable Generative AI Using Patient-Specific Modeling. IEEE Access 2026;14:14965 View
  11. Chen J, Zhang J. A systematic literature review of health‐related information on Question and Answer platforms. Journal of the Association for Information Science and Technology 2026 View
  12. Zhang M, Cai M, Wang Z, Jia L. RAG-for-CR: A Retrieval-Augmented Generation Framework for Efficient, Accurate, and Traceable Querying of Construction Regulations. Journal of Construction Engineering and Management 2026;152(9) View
  13. Balas J, Bowling L, Shakhnazaryan N, Aggarwal R, Borno H, Hong J, Huang F, Tong B, Kwon D. Evaluation of an Artificial Intelligence Communication Platform for Racial Biases in Pretest Education About Prostate Cancer Germline Testing. JCO Clinical Cancer Informatics 2026;10(3) View

Books/Policy Documents

  1. Javadi S, Mirabi S, Gangar M, Ofoghi B. Advances in Information Retrieval. View

Conference Proceedings

  1. Peixoto J, Lyra J, Passos A, Pereira B, Gouveia A, Araujo V. Anais do VI Workshop sobre as Implicações da Computação na Sociedade (WICS 2025). Bridging AI and Psychology: A RAG-Driven Approach to Inhibitory Control and ADHD Interventions View
  2. Dutta A, Mruthyunjaya S, Saddington J, Islam K. 2025 IEEE International Symposium on Emerging Metaverse (ISEMV). Mentalic Net: Development of RAG-Based Conversational AI and Evaluation Framework for Mental Health Support View
  3. Jin X, Wang Z, Yang H, Li M, Du Y. 2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). A Contextualized Semantic Alignment Framework for Biomedical QA with Controllable Evidence Utilization View
  4. R R, Mishra M, G S, B S, P L, N V K. 2025 5th International Conference on Evolutionary Computing and Mobile Sustainable Networks (ICECMSN). Retrieval-Augmented Graph Neural Model for Medical Question Answering System View
  5. Jose P, Manikanta A, B S N. 2026 International Conference on Electronics and Renewable Systems (ICEARS). MedAI+: A Privacy-Aware Multimodal Medical Chat Assistant using Retrieval-Augmented LLM Reasoning View