Published on in Vol 27 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/66220, first published .
Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Sudeshna Das   1 * , PhD ;   Yao Ge   1 * , PhD ;   Yuting Guo   1 , MS ;   Swati Rajwal   2 , MTech ;   JaMor Hairston   1 , MS ;   Jeanne Powell   1 , PhD ;   Drew Walker   1 , PhD ;   Snigdha Peddireddy   3 , MPH ;   Sahithi Lakamana   1 , MS ;   Selen Bozkurt   1 , PhD ;   Matthew Reyna   1 , PhD ;   Reza Sameni   1, 4 , PhD ;   Yunyu Xiao   5 , PhD ;   Sangmi Kim   6 , PhD ;   Rasheeta Chandler   6 , PhD ;   Natalie Hernandez   7 , PhD ;   Danielle Mowery   8 , PhD ;   Rachel Wightman   9 , MD ;   Jennifer Love   10 , MD ;   Anthony Spadaro   11 , MD ;   Jeanmarie Perrone   12 , MD ;   Abeed Sarker   1, 4 , PhD

1 Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States

2 Department of Computer Science and Informatics, Emory University, Atlanta, GA, United States

3 Department of Behavioral, Social & Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA, United States

4 Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States

5 Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States

6 Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States

7 Center for Maternal Health Equity, Morehouse School of Medicine, Atlanta, GA, United States

8 Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

9 Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, United States

10 Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States

11 Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, United States

12 Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

*these authors contributed equally

Corresponding Author:

  • Sudeshna Das, PhD
  • Department of Biomedical Informatics
  • School of Medicine
  • Emory University
  • 101 Woodruff Circle
  • Atlanta, GA, 30322
  • United States
  • Phone: 1 4047270229
  • Email: sudeshna.das@emory.edu