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This paper is in the following e-collection/theme issue:

Viewpoints and Perspectives (1489) Clinical Information and Decision Making (3967) Digital Health, Telehealth and e-Innovation in Clinical Settings (761) Theoretical Frameworks and Concepts (603) mHealth in a Clinical Setting (1245) Digital Health Reporting Standards, Quality and Transparency in e-Research (261)

Published on in Vol 28 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/101269, first published .
Doctor typing on laptop with stethoscope nearby, symbolizing healthcare technology

Beyond Model Choice: A Harness-Centered Framework for Designing Clinical Large Language Model Agents

Beyond Model Choice: A Harness-Centered Framework for Designing Clinical Large Language Model Agents

Authors of this article:

Jialin Liu1, 2 Author Orcid Image ;   Siru Liu3, 4 Author Orcid Image
Article Authors Cited by Tweetations Metrics

Jialin Liu   1, 2 , MD ;   Siru Liu   3, 4 , PhD

1 Department of Medical Informatics, West China Hospital of Sichuan University, Chengdu, Sichuan, China

2 Department of Otolaryngology-Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China

3 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States

4 Department of Computer Science, Vanderbilt University, Nashville, TN, United States

Corresponding Author:

  • Siru Liu, PhD
  • Department of Biomedical Informatics
  • Vanderbilt University Medical Center
  • 2525 West End Ave #1475
  • Nashville, TN 37203
  • United States
  • Phone: 1 6158755216
  • Email: siru.liu@vumc.org