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Digital Health Reviews (1824) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (2261) Artificial Intelligence (2347) Chatbots and Conversational Agents (786) Generative Language Models Including ChatGPT (812)

Published on in Vol 27 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/69284, first published .
The Applications of Large Language Models in Mental Health: Scoping Review

The Applications of Large Language Models in Mental Health: Scoping Review

The Applications of Large Language Models in Mental Health: Scoping Review

Authors of this article:

Yu Jin1 Author Orcid Image ;   Jiayi Liu1 Author Orcid Image ;   Pan Li1 Author Orcid Image ;   Baosen Wang1 Author Orcid Image ;   Yangxinyu Yan2 Author Orcid Image ;   Huilin Zhang3 Author Orcid Image ;   Chenhao Ni3 Author Orcid Image ;   Jing Wang4 Author Orcid Image ;   Yi Li5 Author Orcid Image ;   Yajun Bu5 Author Orcid Image ;   Yuanyuan Wang2 Author Orcid Image
Article Authors Cited by (27) Tweetations Metrics

Journals

  1. Porkaew P, Zhu T, Li A, Chuenphitthayavut K. The effectiveness of a sentence completion test for depression screening using large language models. Acta Psychologica 2025;259:105425 View
  2. Rousmaniere T, Goldberg S, Torous J. Large language models as mental health providers. The Lancet Psychiatry 2026;13(1):7 View
  3. Kumar M, Khan L, Choi A. RAMHA: A Hybrid Social Text-Based Transformer with Adapter for Mental Health Emotion Classification. Mathematics 2025;13(18):2918 View
  4. Dwyer B, Flathers M, Sano A, Dempsey A, Cipriani A, Gazi A, Hill B, Gorban C, Rodriguez C, Stromeyer C, King D, Rozenblit E, Strudwick G, Linardon J, Cheong J, Firth J, Herpertz J, Schwarz J, Truong K, Emerson M, Paulus M, Patriquin M, Hua Y, Choudhary S, Siddals S, Pinillos L, Bantjes J, Schueller S, Xu X, Duckworth K, Gillison D, Wood M, Torous J. Mindbench.ai: an actionable platform to evaluate the profile and performance of large language models in a mental healthcare context. NPP—Digital Psychiatry and Neuroscience 2025;3(1) View
  5. Son D, Kim G, Oh H, Sundar S. A framework for Gaming Disorder Detection based on social media data using Large Language Model labeling. Engineering Applications of Artificial Intelligence 2026;165:113447 View
  6. Elshaer I, Azazz A. The Impacts of Large Language Model Addiction on University Students’ Mental Health: Gender as a Moderator. Algorithms 2025;18(12):789 View
  7. Schwartz Tayri T, Cohen-Inger N, Seadia O, Gal A, Vilenchik D. A case-specific psychological first aid AI recommendations app for rescue and first responders. European Journal of Psychotraumatology 2025;16(1) View
  8. Yeasmin S, Semi M, Rony M, Das S, Sabeena A, Rahman R, Biswas B, Ahmed F, Hossain A. Artificial Intelligence for Mental Health Monitoring: A Solution for Digital Behavioral Health Care and Education—An Umbrella Review. Health Science Reports 2026;9(1) View
  9. Donnelly H, Brown G, Green K, Vurgun U, Hwang S, Schriver E, Steinberg M, Reilly M, Mehta H, Labouliere C, Oquendo M, Mandell D, Mowery D. Automated Safety Plan Scoring in Outpatient Mental Health Settings Using Large Language Models: Exploratory Study. JMIR Mental Health 2026;13:e79010 View
  10. Teferra B, Johny N, Huang S, Rueda A, Kamaleddin M, Dunlop K, Zhang Y, Jha M, Sharma D, Bhat V. Assessing the impact of safety guardrails on large language models using irritability metrics. npj Digital Medicine 2026;9(1) View
  11. Rodríguez Cevallos D. Inteligencia artificial generativa aplicada a la salud mental: un análisis bibliométrico. Salmus 2025;1(2):e9 View
  12. Jin Z, Hu J, Bi D, Zhao K, Yu H. Evaluating the Efficacy of AI-Based Interactive Assessments Using Large Language Models for Depression Screening: Development and Usability Study. JMIR Formative Research 2026;10:e78401 View
  13. Lam C, Xian L, Huang R, Chen J, Chan K, Chan J, Chau S, Chan N, Li S, Wing Y, Li T. Deep learning for detecting depression in individuals with and without alexithymia. Communications Medicine 2026;6(1) View
  14. Voultsiou E, Moussiades L. A Systematic Review of Large Language Models in Mental Health: Opportunities, Challenges, and Future Directions. Electronics 2026;15(3):524 View
  15. Chen Y, Gao Y, Yu S, Zhao C, Lu Y. Large Language Models in Mental Health: A Systematic Review of Applications, Innovations and Ethical Challenges. Journal of Industrial Integration and Management 2026:1 View
  16. Yang J, Liu T, Luo Y, Niu T, Pang P, Xiang A, Yang Q. Exploring the application boundaries of LLMs in mental health: a systematic scoping review. Frontiers in Psychology 2026;16 View
  17. Cheng A, Konova A, Powers A, Corlett P, Levy I, Gu X, Huys Q, Pushkarskya H, Fineberg S, Hauser T, Bzdok D, Harpaz-Rotem I, Babuscio T, Nichols L, Zhao Y, Sharma M, Meeker D, Xu H, Rutledge R, Pearlson G, Pittenger C, Yip S. Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2026 View
  18. Irmawati S , Fanny Fatimah Mayasari Masdar , Rosdianah , Muh.Yunus . Digital mental health education: the impact of e-book intervention on anxiety knowledge among adolescent girls. Jurnal Ilmiah Kesehatan Sandi Husada 2025;14(2):323 View
  19. AlSaad R, Alshakhs S, Thomas R. Depression subtype classification from social media posts: few-shot prompting vs. fine-tuning of large language models. Frontiers in Digital Health 2026;8 View
  20. Nofita Tudang Rombeallo , Indrawati Aris Tyarini , Ari Setiawati . Effect of e-book media on adolescent girls’ knowledge of mental health issues anxiety. Jurnal Ilmiah Kesehatan Sandi Husada 2025;14(2):266 View
  21. Klein A, Song J, Chim J, Keren L, Triantafyllopoulos A, Schuller B, Liakata M, Atzil-Slonim D. Clinical Summaries of Social Media Timelines for Mental Health Monitoring: Human Versus Large Language Model Comparative Evaluation Study. JMIR Formative Research 2026;10:e71230 View

Conference Proceedings

  1. Steenstra I, Bickmore T. Proceedings of the 25th ACM International Conference on Intelligent Virtual Agents. A Risk Ontology for Evaluating AI-Powered Psychotherapy Virtual Agents View
  2. K R, Rananavare L. 2025 IEEE International Conference on Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER). A Comprehensive Survey on Depression Detection Through Social Media Using Machine Learning and NLP Techniques View
  3. Azade R, Sazzed S. 2025 IEEE International Conference on Big Data (BigData). Zero-Shot Learning Capabilities of Large Language Models (LLMs) in Extracting Key Insights from Suicidal Narratives View
  4. Sazzed S, Azade R, Dehan F, Pial M. 2025 IEEE International Conference on Big Data (BigData). Evaluating the Few-Shot Performance of Large Language Models for Classifying Clinical Risk Factors in Mental Health Text View
  5. Jayakody U, Jayawardhana M, Wickramasiri D. 2025 IEEE 19th International Conference on Industrial and Information Systems (ICIIS). An Enhanced BERT-Based Approach for Mental Health Sentiment Analysis View
  6. Chen P, Liu H, Zhang Y, Yan Y, Tang Y, Tan D. 2025 IEEE 3rd International Conference on Electrical, Automation and Computer Engineering (ICEACE). Research on a Mental Health Service System Based on an Improved RAG Algorithm View