Using Large Language Models to Support Content Analysis: A Case Study of ChatGPT for Adverse Event Detection

Eric C Leas   ^{1, 2} , MPH, PhD ;   John W Ayers   ^{2, 3, 4} , MA, PhD ;   Nimit Desai   ² , BS ;   Mark Dredze   ⁵ , PhD ;   Michael Hogarth   ^{4, 6} , MD ;   Davey M Smith   ^{3, 4} , MAS, MD

¹ Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, United States

² Qualcomm Institute, University of California San Diego, La Jolla, CA, United States

³ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, United States

⁴ Altman Clinical Translational Research Institute, University of California San Diego, La Jolla, CA, United States

⁵ Department of Computer Science, Johns Hopkins University, Baltimore, MD, United States

⁶ Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, United States