Published on in Vol 24, No 1 (2022): January
Preprints (earlier versions) of this paper are
available at
https://preprints.jmir.org/preprint/33081, first published
.

Journals
- von Ulmenstein U, Tretter M, Ehrlich D, Lauppert von Peharnik C. Limiting medical certainties? Funding challenges for German and comparable public healthcare systems due to AI prediction and how to address them. Frontiers in Artificial Intelligence 2022;5 View
- Jiménez López E, Cuenca Jiménez F, Luna Sandoval G, Ochoa Estrella F, Maciel Monteón M, Muñoz F, Limón Leyva P. Technical Considerations for the Conformation of Specific Competences in Mechatronic Engineers in the Context of Industry 4.0 and 5.0. Processes 2022;10(8):1445 View
- Maddahi Y, Chen S. Applications of Digital Twins in the Healthcare Industry: Case Review of an IoT-Enabled Remote Technology in Dentistry. Virtual Worlds 2022;1(1):20 View
- Das C, Mumu A, Ali M, Sarker S, Muyeen S, Das S, Das P, Hasan M, Tasneem Z, Islam M, Islam M, Badal F, Ahamed M, Abhi S. Toward IoRT Collaborative Digital Twin Technology Enabled Future Surgical Sector: Technical Innovations, Opportunities and Challenges. IEEE Access 2022;10:129079 View
- Cho M, Martinez-Martin N. Epistemic Rights and Responsibilities of Digital Simulacra for Biomedicine. The American Journal of Bioethics 2023;23(9):43 View
- Sun T, Wang J, Suo M, Liu X, Huang H, Zhang J, Zhang W, Li Z. The Digital Twin: A Potential Solution for the Personalized Diagnosis and Treatment of Musculoskeletal System Diseases. Bioengineering 2023;10(6):627 View
- Machado T, Berssaneti F. Literature review of digital twin in healthcare. Heliyon 2023;9(9):e19390 View
- Cellina M, Cè M, Alì M, Irmici G, Ibba S, Caloro E, Fazzini D, Oliva G, Papa S. Digital Twins: The New Frontier for Personalized Medicine?. Applied Sciences 2023;13(13):7940 View
- McCradden M. Ethics, First. The American Journal of Bioethics 2023;23(9):55 View
- Chu Y, Li S, Tang J, Wu H. The potential of the Medical Digital Twin in diabetes management: a review. Frontiers in Medicine 2023;10 View
- Gazerani P. Intelligent Digital Twins for Personalized Migraine Care. Journal of Personalized Medicine 2023;13(8):1255 View
- Konopik J, Wolf L, Schöffski O. Digital twins for breast cancer treatment – an empirical study on stakeholders’ perspectives on potentials and challenges. Health and Technology 2023;13(6):1003 View
- Pergolizzi Jr. J, LeQuang J, Vasiliu-Feltes I, Breve F, Varrassi G. Brave New Healthcare: A Narrative Review of Digital Healthcare in American Medicine. Cureus 2023 View
- Sigawi T, Ilan Y. Using Constrained-Disorder Principle-Based Systems to Improve the Performance of Digital Twins in Biological Systems. Biomimetics 2023;8(4):359 View
- Haidar H, Encheva L, Kamenova K. Digital Simulacra Mark an Ontological Shift in Biomedicine with Far-Reaching Consequences for Real Patients. The American Journal of Bioethics 2023;23(9):81 View
- Jabin M, Yaroson E, Ilodibe A, Eldabi T. Ethical and Quality of Care-Related Challenges of Digital Health Twins in Older Care Settings: Protocol for a Scoping Review. JMIR Research Protocols 2024;13:e51153 View
- Xames M, Topcu T. A Systematic Literature Review of Digital Twin Research for Healthcare Systems: Research Trends, Gaps, and Realization Challenges. IEEE Access 2024;12:4099 View
- McCourt C. Exploring the intersection of the medical metaverse and healthcare ethics: future considerations and caveats. Global Health Journal 2024;8(1):36 View
- ALAY D. Kişiselleştirilmiş Tıp İçin Dijital İkiz: Sistematik Derleme. Sağlık Profesyonelleri Araştırma Dergisi 2024;6(1):28 View
- Ferlito B, De Proost M, Segers S. Navigating the Landscape of Digital Twins in Medicine: A Relational Bioethical Inquiry. Asian Bioethics Review 2024;16(3):471 View
- Vallée A. Envisioning the Future of Personalized Medicine: Role and Realities of Digital Twins. Journal of Medical Internet Research 2024;26:e50204 View
- Balasubramanyam A, Ramesh R, Sudheer R, Honnavalli P. Revolutionizing Healthcare: A Review Unveiling the Transformative Power of Digital Twins. IEEE Access 2024;12:69652 View
- Gong P, Chen X, Zhou T, Tian Y, Su M. Digital twin prevalence in the medical caring fields: A bibliomatrics study and visualization analysis through CiteSpace. Interdisciplinary Nursing Research 2024;3(2):126 View
- Vidovszky A, Fisher C, Loukianov A, Smith A, Tramel E, Walsh J, Ross J. Increasing acceptance of AI‐generated digital twins through clinical trial applications. Clinical and Translational Science 2024;17(7) View
- Shoukat M, Yan L, Yan Y, Zhang F, Zhai Y, Han P, Nawaz S, Raza M, Akbar M, Hussain A. Autonomous driving test system under hybrid reality: The role of digital twin technology. Internet of Things 2024;27:101301 View
- Żydowicz W, Skokowski J, Marano L, Polom K. Navigating the Metaverse: A New Virtual Tool with Promising Real Benefits for Breast Cancer Patients. Journal of Clinical Medicine 2024;13(15):4337 View
- Rajamäki J. Digital twin technology training and research in health higher education: a review. Exploration of Digital Health Technologies 2024:188 View
- Abd Elaziz M, Al‐qaness M, Dahou A, Al‐Betar M, Mohamed M, El‐Shinawi M, Ali A, Ewees A. Digital twins in healthcare: Applications, technologies, simulations, and future trends. WIREs Data Mining and Knowledge Discovery 2024;14(6) View
- El-Warrak L, de Farias C. The State of the Art of Digital Twins in Health—A Quick Review of the Literature. Computers 2024;13(9):228 View
- Sheng B, Wang Z, Qiao Y, Xie S, Tao J, Duan C. Detecting latent topics and trends of digital twins in healthcare: A structural topic model-based systematic review. DIGITAL HEALTH 2023;9 View
- Sun Y, Xu C. Digital twins and biodiversity: a conceptual framework of opportunities and challenge. Kybernetes 2024 View
- Elhadj E, Van Horenbeeck Z, Lievevrouw E, Van Hoyweghen I. Brokering responsible research and innovation in in silico medicine. Journal of Responsible Innovation 2024;11(1) View
- D’Orsi L, Capasso B, Lamacchia G, Pizzichini P, Ferranti S, Liverani A, Fontana C, Panunzi S, De Gaetano A, Lo Presti E. Recent Advances in Artificial Intelligence to Improve Immunotherapy and the Use of Digital Twins to Identify Prognosis of Patients with Solid Tumors. International Journal of Molecular Sciences 2024;25(21):11588 View
- Rajamäki J, Helin J. The Ethics and Cybersecurity of Artificial Intelligence and Robotics in Helping The Elderly to Manage at Home. Information 2024;15(11):729 View
- Li T, Shen Y, Li Y, Zhang Y, Wu S. The status quo and future prospects of digital twins for healthcare. EngMedicine 2024;1(3):100042 View
- de Oliveira El-Warrak L, Miceli de Farias C. Could digital twins be the next revolution in healthcare?. European Journal of Public Health 2025;35(1):19 View
- Niarakis A, Laubenbacher R, An G, Ilan Y, Fisher J, Flobak Å, Reiche K, Rodríguez Martínez M, Geris L, Ladeira L, Veschini L, Blinov M, Messina F, Fonseca L, Ferreira S, Montagud A, Noël V, Marku M, Tsirvouli E, Torres M, Harris L, Sego T, Cockrell C, Shick A, Balci H, Salazar A, Rian K, Hemedan A, Esteban-Medina M, Staumont B, Hernandez-Vargas E, Martis B S, Madrid-Valiente A, Karampelesis P, Sordo Vieira L, Harlapur P, Kulesza A, Nikaein N, Garira W, Malik Sheriff R, Thakar J, Tran V, Carbonell-Caballero J, Safaei S, Valencia A, Zinovyev A, Glazier J. Immune digital twins for complex human pathologies: applications, limitations, and challenges. npj Systems Biology and Applications 2024;10(1) View
- Özsezer G, Mermer G. Sağlık Hizmetlerinde Çığır Açan Uygulamalar: İnsan Dijital İkizi ile Geleceğe Yolculuk. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 2024;6(3):648 View
- Tortora M, Pacchiano F, Ferraciolli S, Criscuolo S, Gagliardo C, Jaber K, Angelicchio M, Briganti F, Caranci F, Tortora F, Negro A. Medical Digital Twin: A Review on Technical Principles and Clinical Applications. Journal of Clinical Medicine 2025;14(2):324 View
- Asciak L, Kyeremeh J, Luo X, Kazakidi A, Connolly P, Picard F, O’Neill K, Tsaftaris S, Stewart G, Shu W. Digital twin assisted surgery, concept, opportunities, and challenges. npj Digital Medicine 2025;8(1) View
- Strigari L, Schwarz J, Bradshaw T, Brosch-Lenz J, Currie G, El-Fakhri G, Jha A, Mežinska S, Pandit-Taskar N, Roncali E, Shi K, Uribe C, Yusufaly T, Zaidi H, Rahmim A, Saboury B. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins. Journal of Nuclear Medicine 2025;66(5):748 View
- Asadi A, Akinremi T, Appiah J, Jayathilake H, Ibitoye O, Said H. Bits, Bytes, and Bars: Towards a Digital Twin of the US Criminal Justice System. International Journal of Human–Computer Interaction 2025;41(19):12050 View
- Sohail A, Irfan M, Shaikh A. Revolutionizing Surgical Preparedness: Personalized Preoperative Planning with Digital Twins of an Organ. Surgical Innovation 2025;32(3):315 View
- Wagg D, Burr C, Shepherd J, Xuereb Conti Z, Enzer M, Niederer S. The philosophical foundations of digital twinning. Data-Centric Engineering 2025;6 View
- Diniz P, Grimm B, Garcia F, Fayad J, Ley C, Mouton C, Oeding J, Hirschmann M, Samuelsson K, Seil R. Digital twin systems for musculoskeletal applications: A current concepts review. Knee Surgery, Sports Traumatology, Arthroscopy 2025;33(5):1892 View
- Guerrero Quiñones J, Puzio A. Digital twins for trans people in healthcare: queer, phenomenological and bioethical considerations. Journal of Medical Ethics 2025;51(12):795 View
- Weissenfels S, Nissen A, Smolnik S. Advancing digital health in information systems research: Insights from a text mining analysis. Electronic Markets 2025;35(1) View
- Abrahams M. Digital Twins: The Future of Personalized Nutrition and Health?. Lifestyle Genomics 2025;18(1):59 View
- Tsekleves E, Cooper R, Jacobs N, Cureton P. Designing the future of healthcare: the role of design research in shaping digital twin technologies. Design for Health 2025;9(1):121 View
- Martinez V, Campelo D, Ribeiro M. Sustainable Intelligent Transportation Systems via Digital Twins: A Contextualized Survey. IEEE Open Journal of Intelligent Transportation Systems 2025;6:363 View
- Van Bossuyt D, Allaire D, Bickford J, Bozada T, Chen W, Cutitta R, Cuzner R, Fletcher K, Giachetti R, Hale B, Huang H, Keidar M, Layton A, Ledford A, Lesse M, Lussier J, Malak R, Mesmer B, Mocko G, Oriti G, Selva D, Turner C, Watson M, Wooley A, Zeng Z. The Future of Digital Twin Research and Development. Journal of Computing and Information Science in Engineering 2025;25(8) View
- Bartsch S, Behn O, Benlian A, Brownsword R, Bücker S, Düwell M, Formánek N, Jungtäubl M, Leyer M, Richter A, Schmidt J, Will-Zocholl M. Governance of High-Risk AI Systems in Healthcare and Credit Scoring. Business & Information Systems Engineering 2025;67(4):563 View
- Pammi M, Shah P, Yang L, Hagan J, Aghaeepour N, Neu J. Digital twins, synthetic patient data, and in-silico trials: can they empower paediatric clinical trials?. The Lancet Digital Health 2025;7(5):100851 View
- Mekki Y, Luijten G, Hagert E, Belkhair S, Varghese C, Qadir J, Solaiman B, Bilal M, Dhanda J, Egger J, Deng J, Khanduja V, Frangi A, Zughaier S, Stotland M. Digital twins for the era of personalized surgery. npj Digital Medicine 2025;8(1) View
- Mishra V, Singh J, Rana S, Haque M. System Dynamics-Based Digital Twin for Population Health- A Case of Diabetes Management in the UAE. Procedia Computer Science 2025;260:252 View
- Gu D, Cao Y, Zhou X, Zan Y, Zhang X, Xie J, Yu M. Digital Twins in the Field of Nursing. CIN: Computers, Informatics, Nursing 2025 View
- Passas I. From Digital Twins to Digital Triplets in Economics and Financial Decision-Making. Encyclopedia 2025;5(3):87 View
- Miedel M, Schurdak M, Stern A, Soto-Gutierrez A, Strobl E, Behari J, Taylor D. Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective. Seminars in Liver Disease 2025;45(04):458 View
- Uğraş E. Digital twins in personalized medicine: Insights from a systematic review. The European Research Journal 2025;11(5):1015 View
- Aghamiri S, Amin R, Isavand P, Vahdati S, Zeinoddini A, Kitamura F, Moy L, Kline T. Digital Twin Technology In Radiology. Journal of Imaging Informatics in Medicine 2025 View
- Saratkar S, Langote M, Kumar P, Gote P, Weerarathna I, Mishra G. Digital twin for personalized medicine development. Frontiers in Digital Health 2025;7 View
- März J, Baumgartner M, Blau N, Biller-Andorno N. Digital twins for children with rare diseases: an exploration of the legal and ethical issues. Ethics and Information Technology 2025;27(3) View
- Boretti A. Designing inclusive digital twins: ethical and practical considerations for trans healthcare. Journal of Medical Ethics 2025;51(12):803 View
- Sasitharasarma S, Alani N, Wisker Z. Is the Healthcare Industry Ready for Digital Twins? Examining the Opportunities and Challenges. Future Internet 2025;17(9):386 View
- Doraiswamy P, Duñabeitia J, Rodriguez C, Devanand D. Digital cognitive twins in mental health. Nature Mental Health 2025;3(10):1106 View
- Xames M, Topcu T, Parker S, Zagarese V, Epling J. Evaluating CFIR 2.0 in identifying digital twin implementation challenges in healthcare: bridging the dichotomy between engineering and healthcare communities. Frontiers in Digital Health 2025;7 View
- Jayachandran N, Abdrabou A, Al Bataineh M, Noordin K. An Architecture and Realisation of a Smart City Digital Twin With eHealth Case Studies. IET Smart Cities 2025;7(1) View
- Kim Y, Oh S, Kim G. Convergence of Integrated Sensing and Communication (ISAC) and Digital-Twin Technologies in Healthcare Systems: A Comprehensive Review. Signals 2025;6(4):51 View
- Vallée A, Moawad G, Feki A, Ayoubi J. Digital twins in fertility, assisted reproductive technology and pregnancy: a systematic review. Reproductive BioMedicine Online 2025:105281 View
- Momand Z, Mongkolnam P, Chan J, Charoenkitkarn N, Pal D. Building Digital Twins for Elderly Care: An End-to-End Framework From Data Acquisition to Modeling. IEEE Access 2025;13:169415 View
- Akbarialiabad H, Pasdar A, Murrell D, Mostafavi M, Shakil F, Safaee E, Leachman S, Haghighi A, Tarbox M, Bunick C, Grada A. Enhancing randomized clinical trials with digital twins. npj Systems Biology and Applications 2025;11(1) View
- Vallée A. Digital twins for cardiovascular diseases: towards personalised and sustainable care. Acta Cardiologica 2025;80(9):1055 View
- Shariatpour F, Behzadfar M, Jalilisadrabad S. A socio-technical framework for urban digital twins: Tehran in a global comparison. Sustainable Cities and Society 2025;134:106905 View
- Vallée A. Simulation-based model of menopause: hormonal changes and cardiovascular risk in a digital twin view. Climacteric 2025:1 View
- Weidema J, de Vries M, Mummery C, de Graeff N. The ethical aspects of human organ-on-chip models: A mapping review. Stem Cell Reports 2025;20(11):102686 View
- Din G, Shams M, Rahmani A, Rehman A, Ahmed M, Shoukat M. Comparative analysis on AI-driven human digital twin for personalized and predictive medicine. Journal of Clinical Practice and Medical Research 2025;1(1):30 View
- Xuan Z, Niu Y, Wang Y, Wang Z, Zhao J, Chang H, Xiao Q. Perspectives and Preferences on Developing a Digital Human System for Intrinsic Capacity Monitoring Underpinned by World Health Organization’s Integrated Care for Older People Guideline: Qualitative Study. Journal of Medical Internet Research 2025;27:e76222 View
- Siddiqui R, Lloyd D, Khan N. Integrating molecular pathogenesis and predictive modelling in granulomatous amoebic encephalitis due to Acanthamoeba : a digital twin framework for personalised therapy. Infectious Diseases 2025:1 View
Books/Policy Documents
- De Maeyer C, Lee M. Human-Centered Software Engineering. View
- Barresi G, Gaggioli A, Sternini F, Ravizza A, Pacchierotti C, De Michieli L. mHealth and Human-Centered Design Towards Enhanced Health, Care, and Well-being. View
- Mundru Y, Yogi M, Chatterjee J. Deep Learning in Personalized Healthcare and Decision Support. View
- Iliuță M, Moisescu M, Pop E, Mitulescu T. Service Oriented, Holonic and Multi-Agent Manufacturing Systems for Industry of the Future. View
- Aldea C, Bocu R, Duca Iliescu D. Advanced Information Networking and Applications. View
- Abu el Ata N. Personalized Medicine - New Perspectives. View
- Yingngam B, Khumsikiew J, Netthong R. Digital Twins for Smart Cities and Villages. View
- . Digital Twins and Cybersecurity. View
- Danesh A, El-Sappagh S, Abuhmed T. Sensor Networks for Smart Hospitals. View
- Chugh M, Vyas S. Digital Twins for Sustainable Healthcare in the Metaverse. View
- Kulbacki M, Segen J, Kulbacki M, Chaczko Z, Bożejko W, Paz Suárez Araujo C, Klempous R, Bonikowski M. Computer Aided Systems Theory – EUROCAST 2024. View
- Tripathi S, Chumnanvej S. Smart Healthcare, Clinical Diagnostics, and Bioprinting Solutions for Modern Medicine. View
- Kokkas S, Segkouli S, Votis K. Artificial Intelligence Applications and Innovations. AIAI 2025 IFIP WG 12.5 International Workshops. View
- Morley J, Floridi L. Ethics and Medical Technology. View
- Khatri R, Aryan P. Metaverse and Digital Twins. View
Conference Proceedings
- Gupta A, Sharma S. 2023 Seventh International Conference on Image Information Processing (ICIIP). Gen-AI Perspective in Digital Healthcare: Ownership versus Practicality View
- De Maeyer C, Lee M. Proceedings of the 17th International Conference on PErvasive Technologies Related to Assistive Environments. Exploring Power Dynamics of Healthcare Digital Twins at Home through the Matrix of Domination View
- Pietrantoni L, Román-Niaves M, De Angelis M. 2024 IEEE 29th International Conference on Emerging Technologies and Factory Automation (ETFA). Human Trust and Digital Twins in a Human Factors and Ergonomic Framework View
- Pisirgen A, Hiziroglu O. 2025 International Conference on New Trends in Computing Sciences (ICTCS). Applications of Digital Twin in Precision Medicine: A Systematic Review View
- Foo C, Foong P, Nadal C, Ureyang N, Naylin T, Koh G. Proceedings of the 2025 ACM Designing Interactive Systems Conference. The Benefits and Risks of LLMs for Facilitating Medical Decision-Making Among Laypersons View
- Brand D, Devlin S. 2025 IEEE 9th Forum on Research and Technologies for Society and Industry (RTSI). Ethical, Legal, and Technical Considerations for the Development of Digital Twins in Healthcare View
