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This paper is in the following e-collection/theme issue:

Generative Language Models Including ChatGPT (890) ePrescribing and Innovations in Pharmacies (94) Registered Report (884) Language Accessibility, Equity, and Translation Technologies for Medicine and Public Health (40) Design and Evaluation of Patient Education Materials (139) AI Language Models in Health Care (291)

Published on in Vol 28 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/84444, first published .
Woman using smartphone and holding blister pack of green and pink pills

Large Language Model–Generated Patient Instructions for Prescriptions in Primary Health Care: Preclinical Algorithm Validation

Large Language Model–Generated Patient Instructions for Prescriptions in Primary Health Care: Preclinical Algorithm Validation

Authors of this article:

Zilma Silveira Nogueira Reis1 Author Orcid Image ;   Elisa Tuler Albergaria2 Author Orcid Image ;   Adriana Silvina Pagano3 Author Orcid Image ;   Eura Martins Lage4 Author Orcid Image ;   Flávia Ribeiro de Oliveira4 Author Orcid Image ;   Cristiane dos Santos Dias4 Author Orcid Image ;   Juliana Almeida Oliveira4 Author Orcid Image ;   Gláucia Miranda Varella Pereira4 Author Orcid Image ;   Isaias Jose Ramos de Oliveira4 Author Orcid Image ;   Érico Franco Mineiro5 Author Orcid Image ;   Igor Carvalho Lima Oliveira5 Author Orcid Image ;   Davi dos Reis de Jesus2 Author Orcid Image ;   Antônio Pereira de Souza Júnior2 Author Orcid Image ;   Igor de Carvalho Gomes6 Author Orcid Image ;   Rodrigo André Cuevas Gaete6 Author Orcid Image ;   Ricardo Cruz-Correia7 Author Orcid Image ;   Leonardo Rocha2 Author Orcid Image
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Zilma Silveira Nogueira Reis   1 * , MD, PhD ;   Elisa Tuler Albergaria   2 * , CS, PhD ;   Adriana Silvina Pagano   3 * , AS, PhD ;   Eura Martins Lage   4 * , MD, PhD ;   Flávia Ribeiro de Oliveira   4 * , MD, PhD ;   Cristiane dos Santos Dias   4 * , MD, PhD ;   Juliana Almeida Oliveira   4 * , MD ;   Gláucia Miranda Varella Pereira   4 * , PhD ;   Isaias Jose Ramos de Oliveira   4 * , MSCS ;   Érico Franco Mineiro   5 * , PhD ;   Igor Carvalho Lima Oliveira   5 * , MDS ;   Davi dos Reis de Jesus   2 * , CS ;   Antônio Pereira de Souza Júnior   2 * , MSCS ;   Igor de Carvalho Gomes   6 * , MSc ;   Rodrigo André Cuevas Gaete   6 * , CS, PhD ;   Ricardo Cruz-Correia   7 * , CS, PhD ;   Leonardo Rocha   2 * , CS, PhD

1 Health Informatics Center, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

2 Computer Science Department, Universidade Federal de São João Del Rei, São João Del Rei, Brazil

3 Arts Faculty, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

4 Department of Physiotherapy, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

5 School of Architecture, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

6 National Secretary of Primary Care of the Brazilian Ministry of Health, Brasilia, Brazil

7 MEDCIDS, Porto University, Porto, Portugal

*all authors contributed equally

Corresponding Author:

  • Zilma Silveira Nogueira Reis, MD, PhD
  • Health Informatics Center
  • Universidade Federal de Minas Gerais
  • Avenida Professor Alfredo Balena, 190
  • Belo Horizonte 30130100
  • Brazil
  • Phone: 55 31985177473
  • Email: zilma.medicina@gmail.com