Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial

Mirai So   ^{1 *} , MD, MBA, PhD ;   Yoichi Sekizawa   ^{2 *} , MA ;   Sora Hashimoto   ^{3 *} , MA ;   Masami Kashimura   ^{4 *} , PhD ;   Hajime Yamakage   ^{5 *} , MEng ;   Norio Watanabe   ^{6 *} , MD, PhD

¹ Department of Psychiatry, Tokyo Dental College, Tokyo, Japan

² Research Institute of Economy, Trade and Industry, Tokyo, Japan

³ United Health Communication Co., Ltd., Tokyo, Japan

⁴ Department of Psychology, Faculty of Human Schiences, Tokiwa University, Ibaraki, Japan

⁵ Department of Medical Statistics, Satista Co., Ltd., Kyoto, Japan

⁶ Department of Psychiatry, Soseikai General Hospital, Kyoto, Japan

*all authors contributed equally