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Published on in Vol 28 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/104186, first published .
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Effectiveness of Conversational Agents for Depression and Anxiety: Systematic Review and Network Dose-Response Meta-Analysis of Agent Types, Dose, and Human Support

Effectiveness of Conversational Agents for Depression and Anxiety: Systematic Review and Network Dose-Response Meta-Analysis of Agent Types, Dose, and Human Support

Pengyu Yang   1 , PhD ;   Ping Lei Chui   1 , PhD ;   Mingxin He   2 , MSN ;   Yao Wu   3 , MSN ;   Pengfei Cheng   4 , PhD ;   Minxiang Li   5, 6 , MSN ;   Haojie Sun   7 , BSN ;   Lurong Cai   7 , BSN ;   Hua Zhang   6, 8 , PhD

1 Faculty of Nursing, Universiti Malaya, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia

2 Department of Intensive Care Unit, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

3 Department of Nursing, Leshan Vocational and Technieal College, Leshan, Sichuan, China

4 Faculty of Medicine, Macau University of Science and Technology, Macau, Macau, China

5 Department of Nursing, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China

6 School of Nursing, Hainan Medical University, Haikou, Hainan, China

7 Department of Psychiatry, Ziyang Psychosis Hospital, Ziyang, Sichuan, China

8 School of Nursing, Hainan Health Vocational College, Haikou, Hainan, China

Corresponding Author:

  • Ping Lei Chui, PhD
  • Faculty of Nursing
  • Universiti Malaya
  • Lembah Pantai
  • Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur 50603
  • Malaysia
  • Phone: 60 12 7128893
  • Email: chuipinglei@um.edu.my