Published on in Vol 27 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/71956, first published .
Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach

Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach

Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach

Christopher J Medberry   1 , PhD, RAC ;   Charlotte Zoe Angel   2 , PhD ;   Ashita S Batavia   1 , MD, MS ;   Sarah Bradley   3 , RN, CNML, BCMAS ;   Nunzio Camerlingo   4 , PhD ;   Melinda Chen   5 , PhD ;   Mohamed Datoo   1 , PharmD ;   Premal Kamdar   6 , MBE ;   Erik Koenig   5 , MBA ;   Lieke Kusters   7 , MSc ;   Celine Marquez   8 , MD ;   Ujwani Nukala   9 , PhD ;   Michael Pettinati   10 , PhD ;   Ruth Phillips   3 , MS, BSN, RN, OCN ;   Daniel P Sanchez   1 , MA ;   Nazila Shafagati   11 , MD ;   Jenifer Siegelman   5 , MD, MPH ;   Mark Stewart   12 , PhD ;   Cindy Varga   13 , MD ;   Benjamin Vandendriessche   14, 15 , PhD ;   Matt Wilkes   16 , PhD, MBChB ;   Dana L Wolff-Hughes   17 , PhD ;   David Zahavi   17 , PhD ;   Sylvain Zorman   10 , PhD ;   Samantha J McClenahan   14 , PhD

1 Johnson and Johnson Innovative Medicine, New Brunswick, NJ, United States

2 Fosanis GmbH, Berlin, Germany

3 Blue Spark Technologies, Inc, Westlake, OH, United States

4 Pfizer, Inc, Cambridge, MA, United States

5 Takeda (United States), Cambridge, MA, United States

6 Bristol Myers Squibb, Princeton, NJ, United States

7 Roche (Switzerland), Basel, Switzerland

8 Genentech, San Francisco, CA, United States

9 Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States

10 ActiGraph, Pensacola, FL, United States

11 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD, United States

12 Friends of Cancer Research, Washington, DC, United States

13 Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, NC, United States

14 Digital Medicine Society, Boston, MA, United States

15 Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States

16 Current Health Inc, Dover, DE, United States

17 National Cancer Institute, Bethesda, MD, United States

Corresponding Author: