Privacy-by-Design Approach to Generate Two Virtual Clinical Trials for Multiple Sclerosis and Release Them as Open Datasets: Evaluation Study

Stanislas Demuth   ^{1, 2} , MD, PhD ;   Olivia Rousseau   ¹ , MSc ;   Igor Faddeenkov   ¹ , MSc ;   Julien Paris   ¹ , MSc ;   Jérôme De Sèze   ^{2, 3} , MD, PhD ;   Béatrice Baciotti   ⁴ , MIM ;   Marianne Payet   ⁵ , PhD ;   Morgan Guillaudeux   ⁶ , MSc ;   Alban-Félix Barreteau   ⁶ , MSc ;   David Laplaud   ^{1, 7} , MD, PhD ;   Gilles Edan   ⁸ , MD ;   Pierre-Antoine Gourraud   ^{1, 9} , MPH, PhD

¹ Center for Research in Transplantation and Translational Immunology, Institut national de la santé et de la recherche médicale (INSERM), Nantes Université, Nantes, France

² Institut national de la santé et de la recherche médicale (INSERM) 1434, Clinical investigation center, University Hospital of Strasbourg, Strasbourg, France

³ Department of Neurology, University Hospital of Strasbourg, Strasbourg, France

⁴ Biogen France S.A.S, Paris, France

⁵ Neurology, Merck Santé S.A.S., an affiliate of Merck KGaA, Lyon, France

⁶ Octopize, Mimethik Data, Nantes, France

⁷ Department of Neurology, University Hospital of Nantes, Nantes, France

⁸ Department of Neurology, University Hospital of Rennes, Rennes, France

⁹ Data Clinic, Department of Public Health, University Hospital of Nantes, Nantes, France