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Journal Description

The Journal of Medical Internet Research (JMIR) is the pioneer open access eHealth journal, and is the flagship journal of JMIR Publications. It is a leading health services and digital health journal globally in terms of quality/visibility (Journal Impact Factor 6.0, Journal Citation Reports 2025 from Clarivate), ranking Q1 in both the 'Medical Informatics' and 'Health Care Sciences & Services' categories, and is also the largest journal in the field. The journal is ranked #1 on Google Scholar in the 'Medical Informatics' discipline. The journal focuses on emerging technologies, medical devices, apps, engineering, telehealth and informatics applications for patient education, prevention, population health and clinical care.

JMIR is indexed in all major literature indices including National Library of Medicine(NLM)/MEDLINE, Sherpa/Romeo, PubMed, PMCScopus, Psycinfo, Clarivate (which includes Web of Science (WoS)/ESCI/SCIE), EBSCO/EBSCO Essentials, DOAJ, GoOA and others. Journal of Medical Internet Research received a Scopus CiteScore of 11.7 (2024), placing it in the 92nd percentile (#12 of 153) as a Q1 journal in the field of Health Informatics. It is a selective journal complemented by almost 30 specialty JMIR sister journals, which have a broader scope, and which together receive over 10,000 submissions a year. 

As an open access journal, we are read by clinicians, allied health professionals, informal caregivers, and patients alike, and have (as with all JMIR journals) a focus on readable and applied science reporting the design and evaluation of health innovations and emerging technologies. We publish original research, viewpoints, and reviews (both literature reviews and medical device/technology/app reviews). Peer-review reports are portable across JMIR journals and papers can be transferred, so authors save time by not having to resubmit a paper to a different journal but can simply transfer it between journals. 

We are also a leader in participatory and open science approaches, and offer the option to publish new submissions immediately as preprints, which receive DOIs for immediate citation (eg, in grant proposals), and for open peer-review purposes. We also invite patients to participate (eg, as peer-reviewers) and have patient representatives on editorial boards.

As all JMIR journals, the journal encourages Open Science principles and strongly encourages publication of a protocol before data collection. Authors who have published a protocol in JMIR Research Protocols get a discount of 20% on the Article Processing Fee when publishing a subsequent results paper in any JMIR journal.

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Recent Articles:

  • AI-generated illustration of older adults engaging with digital preventive health information, reflecting media-based campaign outreach for vaccination and screening. Generator: Google Gemini March 3, 2026. Requestor: Juyoung Park. Source: Google Gemini; Copyright: N/A (AI-Generated image); URL: https://jmir.org/2026/1/e88429/; License: Public Domain (CC0).

    Channel Allocation and Equity in Preventive Campaigns for Older Adults: Agent-Based Modeling Study

    Abstract:

    Background: Preventive campaigns for older adults must decide how to allocate limited resources across media channels. However, these channel allocation and budget decisions rarely use explicit criteria for distributional equity or structured strategic planning tools. Consequently, health systems may optimize average uptake while leaving large gaps across socioeconomic groups and media use profiles. Objective: This study aimed to develop and apply a data-driven agent-based model as a strategic planning tool for preventive campaigns targeting older adults, comparing channel allocation, personalization, and loss framing options under explicit budget and equity guardrails. Methods: We built an agent-based model calibrated to national survey data from South Korea on influenza vaccination and routine health screening among older adults (vaccination, N=2405; screening, N=2400). Fifteen prespecified campaign scenarios varied channel allocation across television, digital, and print media; budget intensity; 2 equity-focused personalization strategies; and graded loss framing. Primary outcomes were final adoption and time to adoption. Equity outcomes included the minimum class-level adoption and 90‐10 gap across latent classes. Each scenario was simulated over 12 monthly steps with 100 Monte Carlo replications. We conducted sensitivity analyses varying link functions and key social reinforcement parameters. Results: Personalization improved uptake and equity relative to the integrated baseline. In the vaccination model (N=2405), adoption increased from 91.2% (n=2193) to 93.3% (n=2244) and 94.6% (n=2275). Minimum class-level adoption increased from 86.8% to 90.3% and 90.9%. The 90‐10 gap narrowed from 5.7 to 4.5 and 4.7 percentage points. In the screening model (N=2400), adoption increased from 83.8% (n=2011) to 88.2% (n=2117) and 89.5% (n=2148). Minimum class-level adoption increased from 77.6% to 83.2% and 85.3%. The 90‐10 gap narrowed from 9.2 to 7.4 and 6.2 percentage points. Television-only strategies achieved high adoption but had less favorable equity profiles than personalization. High-budget strategies achieved high adoption but required higher total exposure. Stronger loss framing produced small, monotonic gains in adoption and shortened the time to adoption without worsening equity in the tested range. Scenario rankings were stable in sensitivity analyses. Conclusions: This agent-based modeling study illustrates how ex ante planning can improve preventive campaign design by comparing channel allocation and personalization options under explicit equity and budget criteria. For campaigns targeting older adults, equity-focused reweighting and class-tailored television-digital portfolios improved or preserved mean adoption while strengthening distributional equity under fixed budgets. In contrast, undifferentiated channel diversification without personalization offered a less favorable efficiency-equity trade-off. These findings support integrating explicit equity guardrails into early-stage channel allocation and prioritizing targeted personalization over simple channel diversification. Future work should validate these patterns in other populations and health systems and link simulated diffusion trajectories with observed exposure and engagement in real-world campaigns. It should also extend guardrail-based planning tools to organizational settings and multiyear decision contexts.

  • Source: Freepik; Copyright: Freepik; URL: https://www.freepik.com/free-photo/medium-shot-woman-wearing-halal-outdoors_59234136.htm; License: Licensed by JMIR.

    Digital Primary Health in Rwanda: Qualitative Study of User Experiences and Implementation Lessons From Babyl’s Telemedicine Platform

    Abstract:

    Background: Digital health innovations address health care accessibility challenges in low- and middle-income countries. Babyl, Rwanda’s largest telemedicine platform, reached 450 of 510 health facilities and enrolled 2 million patients before halting in September 2023 for system redesign. Limited research has explored implementation experiences and user perspectives that influenced its sustainability. Objective: This study aims to explore user experiences and implementation lessons from Babyl’s digital health platform, examining drivers that supported or hindered adoption and scale-up. This qualitative study uniquely examines the lived experiences of diverse stakeholders, active users, lapsed users, nonusers, health care providers, and Babyl agents to understand implementation challenges that contributed to the platform’s halt. Methods: A qualitative, cross-sectional study used 20 focus group discussions (FGDs) and 32 key informant interviews (KIIs) across 12 health centers in ten districts with diverse utilization rates, geographic locations, and Babyl agent availability. FGDs captured collective community perspectives while KIIs provided in-depth individual experiences, enabling data triangulation. FGDs included active users, lapsed users, registered nonusers, and eligible nonregistrants. KIIs involved health center heads, health care providers, and Babyl agents. Data were analyzed using thematic analysis following Braun and Clarke’s framework. Data saturation was achieved when no new themes emerged from the last 3 FGDs and 5 KIIs. All transcripts were validated through member checking with a subset of participants, and intercoder reliability was established with a Cohen kappa of 0.82 across 2 independent coders. Results: Five themes emerged: (1) knowledge and perceptions of digital health, (2) enablers and barriers to utilization, (3) experience and satisfaction, (4) benefits, and (5) improvement suggestions. Participants held positive perceptions of digital health for improving access and reducing wait times. Key enablers included qualified providers, convenience, privacy, and Babyl agents. Major barriers included negative perceptions of remote care quality, service delays, limited digital literacy, device access challenges, and inadequate health facility integration. Users reported high satisfaction with consultations but experienced process confusion. Patient and provider perspectives diverged: patients emphasized convenience, while providers expressed concerns about diagnostic limitations without physical examination. Digital literacy and smartphone access were pronounced barriers among rural and older participants. Recommendations included community mobilization, universal agent deployment, expanded coverage, and sustainable financing. Conclusions: Multiple implementation challenges at individual, community, health system, and policy levels contributed to Babyl’s discontinuation. Critical lessons include the importance of genuine health system integration, sustainable financing, stakeholder engagement, and gradual scaling. Findings provide insights for Rwanda’s health sector digitalization and other African nations investing in telemedicine platforms.

  • Boon-How Chew, MD, MMed, PhD. Source: Author; Copyright: Author; URL: https://www.jmir.org/2026/1/e96018; License: Licensed by JMIR.

    Our AI-Powered Discoveries Are Trapped in a Predigital System

    Authors List:

    Abstract:

  • AI-generated image, in response to the request "Gentle daylight clinical workspace, half-body female doctor side profile consulting via computer, visible patient on screen" (Generator: Freepik AI Image Generator January 27, 2026; Requestor: Xiaohui Zhai). Source: Created with Freepik AI Image Generator; Copyright: N/A (AI Generated Image); URL: https://www.jmir.org/2026/1/e82285; License: Public Domain (CC0).

    Association Between Telemedicine Adoption and Physician Job Satisfaction: Cross-Sectional Study

    Abstract:

    Background: Telemedicine has expanded rapidly in recent years, with particularly pronounced growth following the COVID-19 pandemic. By improving access to care and offering greater flexibility in service delivery, it has become an important component of health care. Although the benefits of telemedicine for patients are well documented, its effects on physician job satisfaction remain insufficiently understood. Given the importance of job satisfaction for workforce stability, physician well-being, and quality of care, further examination of how telemedicine affects physician job satisfaction is warranted. Objective: This study aims to examine the association between telemedicine adoption and physician job satisfaction and to assess whether the physician-patient relationship mediates this association. Methods: A cross-sectional survey was conducted among health care professionals in Xi’an, China. Data were collected between November 7 and December 8, 2023, via an online questionnaire administered using the REDCap (Research Electronic Data Capture; Vanderbilt University) platform. A total of 12,052 physicians were included in the analysis. Physician job satisfaction was measured using a validated 6-point Likert scale. Telemedicine adoption was assessed through self-report. A partial proportional odds model was used to examine the association between telemedicine adoption and job satisfaction, adjusting for a comprehensive set of potential confounders. Additionally, the Karlson-Holm-Breen (KHB) decomposition method was used to explore the mediating role of physician-patient relationship quality in this association. Results: Among 12,052 surveyed physicians, 1642 (13.62%) reported adopting telemedicine, whereas 10,410 (86.38%) did not. After adjusting for demographic characteristics, work-related factors, psychological factors, and physician-patient relationship, telemedicine adoption was significantly associated with higher job satisfaction (odds ratio [OR] 1.17, 95% CI 1.05‐1.30). Findings were robust across multiple sensitivity analyses. Subgroup analyses indicated that the association did not vary across physician subgroups, and no significant interaction effects were observed. Mediation analysis revealed a total effect of telemedicine on job satisfaction of 0.33 (95% CI 0.17‐0.50), with an indirect effect of 0.10 (95% CI 0.07‐0.13) through improved physician-patient relationships, accounting for 30.30% of the total effect. Conclusions: These findings suggest that telemedicine adoption is positively associated with physician job satisfaction, partially mediated by the physician-patient relationship. Policies should promote telemedicine adoption while prioritizing platform designs that support effective physician-patient interactions to enhance provider well-being and care outcomes.

  • Tejas Athni, MS. Source: The Author; Copyright: The Author; URL: https://www.jmir.org/2026/1/e96199; License: Licensed by JMIR.

    Emerging Risks of AI-to-AI Interactions in Health Care: Lessons From Moltbook

    Authors List:

    Abstract:

  • Shalini Narang, MA. Source: The Author; Copyright: The Author; URL: https://www.jmir.org/2026/1/e95657; License: Licensed by JMIR.

    Further Promise and Potential for Precision Medicine in Oncology

    Abstract:

  • Source: Freepik; Copyright: Freepik; URL: https://www.freepik.com/free-photo/close-up-food-lover-taking-pictures-meal_22895782.htm; License: Licensed by JMIR.

    Designing a Carbohydrate Counting App for Young Adults With Type 1 Diabetes: Usability Testing Interview Study

    Abstract:

    Background: Carbohydrate counting (CC) assists people with type 1 diabetes (T1D) adjust mealtime insulin doses; however, it is often burdensome. Mobile apps can simplify this process by automating carbohydrate estimation and insulin calculations, yet no comprehensive solution currently combines photo-based carbohydrate recognition with an integrated bolus calculator. Objective: This study aimed to identify user-informed design principles from usability testing interviews to optimize a novel app supporting young adults with T1D in CC and insulin dosing. Methods: We conducted 4 iterative rounds of usability testing interviews, each with 3 to 5 participants, using a think-aloud protocol to evaluate how easily and effectively users interacted with the app and to identify areas for improvement. Interviews were analyzed qualitatively to derive main design principles, and findings from each round informed the refinement of the app prior to subsequent testing. Results: A total of 18 participants completed the usability testing (median age of 23, IQR 19-24 y and diabetes duration of 9, IQR 6-12 y; n=12, 66.7% young women). Thematic analysis highlighted that a person-centered design that prioritizes the lived experiences of youth with T1D was essential to position the app as a self-management support system, beyond a clinical tool. Personalization was central, including customizable treatment profiles, tailored dashboard metrics, esthetic preferences, and artificial intelligence–driven recommendations based on personal trends. Early usability barriers revealed the need for intuitive navigation, streamlined multistep processes, and clear guidance for data entry and interpretation. Participants valued culturally inclusive content and familiar terminology to enhance accessibility and engagement. Users perceived strong potential for the app to centralize diabetes management tasks, integrate contextual factors (eg, exercise, diet, and timing of insulin) with glucose data, generate sharable reports to facilitate patient-practitioner communication, and strengthen self-efficacy through personalized trend analysis. Concerns about over-reliance on automation underscored the necessity of transparent data verification and user override options to maintain trust in insulin dosing decisions. Conclusions: Iterative usability testing highlighted the importance of balancing automation with user control, personalization, and contextual understanding of personal trends, as key design principles to enhance engagement and the apps’ relevance as a self-management tool. Incorporating these features into a CC and insulin-dosing app could improve self-efficacy in youth living with T1D.

  • Source: Freepik; Copyright: DC Studio; URL: https://www.freepik.com/free-photo/afro-american-practitioner-doctor-discussing-recovery-treatment-with-sick-man_16681208.htm; License: Licensed by JMIR.

    From Knowledge Graphs to Digital Twins: Perspectives on Modeling Patient Outcomes for Health Care Quality Assessment

    Abstract:

    Medical applications of mathematical modeling, including machine learning models, knowledge graphs, and health digital twins, primarily involve the prediction of patient outcomes. This expert perspective examines how mathematical modeling can contribute to health care quality management. Definitions of procedures, patient outcomes, and quality metrics are provided with a quantitative focus. The emphasis is subsequently placed on 3 categories of patient-centered quality of care, namely, patient safety, procedure accuracy, and procedure efficacy, for which a conceptual and mathematical description is provided. Different levels of modeling tasks essential for managing patient-centered quality of care are identified. This article facilitates a deeper understanding of the topic by assigning relevant publications to these 3 quality categories. Focus is placed on the applicability of graph-based methods, including knowledge graphs and health digital twins, to improve quality management in health care. We have presented a clinical scenario and provided information on methodological limitations, future research directions, and practical implications.

  • Source: Freepik; Copyright: DC Studio; URL: https://www.freepik.com/free-photo/doctor-uses-digital-tools-smart-health-systems-provide-personalized-care_418613363.htm; License: Licensed by JMIR.

    Artificial Intelligence Tools for Automating Evidence Synthesis: Scoping Review

    Abstract:

    Background: Rapidly and accurately synthesizing large volumes of evidence is a time- and resource-intensive process. Once published, reviews often risk becoming outdated, limiting their usefulness for decision makers. Recent advancements in artificial intelligence (AI) have enabled researchers to automate stages of the evidence synthesis process, from literature searching and screening to data extraction and analysis. As previous reviews on this topic have been published, a significant number of tools have been further developed and evaluated. Furthermore, as generative AI increasingly automates evidence synthesis, understanding how it is studied and applied is crucial, given both its benefits and risks. Objective: This review aimed to map the current landscape of evaluated AI tools used to automate evidence synthesis. Methods: Following the Joanna Briggs Institute methodology for scoping reviews, we searched Ovid MEDLINE, Ovid Embase, Scopus, and Web of Science in February 2025 and conducted a gray literature search in April 2025. We included articles published in any language from January 2021 onward. Two reviewers independently screened citations using Rayyan, and data were extracted based on study design and key AI-related technical features. Results: We identified 7841 unique citations through database searches and 19 records through gray literature searching. A total of 222 articles were included in the review. We identified 65 AI tools and 25 open-source models or machine learning (ML) algorithms that automate parts of or the whole evidence synthesis pathway. A total of 54.1% (n=120) of the studies were published in 2024, reflecting a trend toward researching general-purpose large language models (LLMs) for evidence synthesis automation. The most popular tool studied was generative pretrained transformer models, including its conversational interface ChatGPT (n=70, 31.5%). Moreover, 31.1% (n=69) studied tools automated by traditional ML algorithms. No studies compared traditional ML tools to LLM-based tools. In addition, 61.7% (n=137) and 26.1% (n=58) studied AI-assisted automation of title and abstract screening and data extraction, respectively, the 2 most intensive stages and, therefore, amenable to automation. Technical performance outcomes were the most frequently reported, with only 4.1% (n=9) of studies reporting time- or workload-specific outcomes. Few studies pragmatically evaluated AI tools in real-world evidence synthesis settings. Conclusions: This review comprehensively captures the broad, evolving suite of AI automation tools available to support evidence synthesis, leveraged by increasingly complex AI approaches that range from traditional ML to LLMs. The notable shift toward studying general-purpose generative AI tools reflects how these technologies are actively transforming evidence synthesis practice. The lack of studies in our review comparing different AI approaches for specific automation stages or evaluating their effectiveness pragmatically represents a significant research gap. Optimal tool selection will likely depend on the review topic and methodology and researcher priorities. While they offer potential for reducing workload, ongoing evaluation to mitigate AI bias and to ensure the integrity of reviews is essential for safeguarding evidence-based decision-making.

  • AI-generated image, prompt not available. Source: Image created with Gemina AI; Copyright: N/A (AI-generated image); URL: https://www.jmir.org/2026/1/e78103; License: Public Domain (CC0).

    Digital Intervention (MiVacunaLA 2.0) to Promote COVID-19 Vaccine Acceptance Among Hispanic Children: Community-Based Randomized Controlled Trial

    Abstract:

    Background: Early in the children’s COVID-19 rollout in the United States, racial and ethnic vaccination rate disparities were evident. Based on COVID-19 communication literature and qualitative interviews with Hispanic parents, we developed a mobile phone–delivered digital intervention to address factors associated with low vaccine confidence. Objective: We conducted a community-based randomized controlled trial of a digital intervention called MiVacunaLA/MyShotLA to increase COVID-19 vaccine uptake among Hispanic children. The fully automated digital intervention was designed in collaboration with community organizations and linguistically and culturally tailored to meet the informational needs of Hispanic caregivers. The intervention focused on families with unvaccinated children 5 to 11 years old but was offered to families with any unvaccinated children 17 years or younger. Methods: Participants were recruited with community organization partners and trained parent ambassadors via an open online screener. The 4-week intervention consisted of 3 SMS text messages with culturally and linguistically tailored educational information weekly. Intervention materials were delivered digitally through a closed online platform. Study team members were blinded. We used a difference-in-difference model with an intention-to-treat approach. The primary outcome was self-reported COVID-19 vaccine uptake among household children collected via online questionnaires. Secondary outcomes included COVID-19 vaccine knowledge, vaccine trust, and measures of participant engagement. We conducted a sensitivity analysis using the treatment-on-the-treated approach. Results: In total, 254 participants completed the baseline survey (128 control and 126 intervention). The average participant age was 34 (SD 6.3) years with an average of 1.7 (SD 0.8) minors in the household, and among households, 62.2% (n=158) reported having children aged 5 to 11 years old. Most participants (n=207, 81.5%) reported English as their primary language. We found a statistically significant difference of 13.3% (95% CI 0.3%-26.4%; =.04) points in self-reported vaccine uptake between intervention and control groups among caregivers of Hispanic children aged 5 to 11 years old. We also found a statistically significant point difference of 14.3% (95% CI 0%‐23.7%; =.003) between intervention and control groups in trust of governmental approval processes for the children’s COVID-19 vaccine. Most participants reported that the weekly digital videos and educational information were “very” (892/1031, 86.5%) or “extremely” (888/1019, 87.1%) useful. Conclusions: MiVacunaLA demonstrates that a culturally tailored, community-based, mobile phone–delivered vaccine educational intervention can increase COVID-19 vaccine uptake among Hispanic children and improve caregivers’ trust in governmental vaccine processes. MiVacunaLA is innovative in its integration of community-informed design with a fully automated, mobile phone–centric format and builds on prior literature by prospectively evaluating a culturally tailored, SMS text messaging–linked web curriculum in a community setting. Findings provide evidence that scalable, low-cost, digital strategies can measurably improve trust and uptake in a population facing persistent vaccination gaps. Real-world implications include the portability and adaptability of this approach across diverse communities and settings to support timely, community-engaged vaccination efforts for broader applicability and scalability in public health. Trial Registration: ClinicalTrials.gov NCT05234372; https://clinicaltrials.gov/study/NCT05234372

  • Source: Pixabay; Copyright: jarmoluk; URL: https://pixabay.com/photos/medications-tablets-medicine-cure-257336/; License: Licensed by JMIR.

    Effectiveness of Mobile Health for Improving Medication Adherence in Patients With Cancer: Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Abstract:

    Background: Medication adherence among patients with cancer is generally low. Mobile health (mHealth) has gradually been applied to improve this situation, but systematic evidence of its effectiveness remains lacking. Objective: We aimed to evaluate the effect of mHealth on improving medication adherence among patients with cancer. Methods: This systematic review included randomized controlled trials (RCTs) evaluating the impact of mHealth on medication adherence among patients with cancer. Systematic searches were conducted in PubMed, Web of Science, CINAHL, Cochrane Library, Embase, Sinomed, CNKI, Cqvip, and ClinicalTrials.gov from inception to December 31, 2025. Two researchers independently performed literature screening, data extraction, and risk of bias assessment. Effects were pooled using a random-effects model (Hartung-Knapp-Sidik-Jonkman), and standardized mean differences (SMDs) and odds ratios (ORs) with 95% CIs have been reported. Evidence quality was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) framework. Results: A total of 17 RCTs (1309 participants) from 8 countries published between 2016 and 2025 were included. mHealth interventions included mobile apps, websites, and text messaging services. The meta-analysis revealed that compared with controls, mHealth interventions significantly improved medication adherence rates (OR 3.47, 95% CI 1.92-6.26; =.002), medication adherence scores (SMD 1.01, 95% CI 0.51-1.52; =.001), self-efficacy (SMD 0.90, 95% CI 0.29-1.51; =.01), and service satisfaction while reducing symptom burden (SMD −0.38, 95% CI −0.61 to −0.14; =.008). However, mHealth had no significant effect on health literacy (SMD 0.51, 95% CI –1.50 to 2.52; =.29). Subgroup analysis revealed that interventions lasting <3 months outperformed those lasting ≥3 months in improving adherence scores (SMD 1.37, 95% CI 0.78-1.96 vs SMD 0.49, 95% CI −0.39 to 1.37; ²=5.98; =.01). Regarding intervention format, text messaging services demonstrated superior efficacy compared with mobile apps and websites (SMD 1.53, 95% CI −5.49 to 8.55 vs SMD 1.01, 95% CI 0.42-1.61 and SMD 0.11, 95% CI −0.34 to 0.56, respectively; ²=10.28; =.006). Across cancer types, mHealth most significantly improved adherence scores in patients with breast cancer (SMD 1.29, 95% CI −5.25 to 7.83), outperforming the findings in patients with leukemia and other cancer types (SMD 0.28, 95% CI −0.87 to 1.42 and SMD 1.09, 95% CI 0.10-2.08, respectively; ²=8.86; =.01). Conclusions: Our findings confirm that mHealth plays a positive role in improving medication adherence, enhancing patient self-efficacy, increasing patient satisfaction with services, and alleviating symptom burden. However, these findings should be interpreted with caution owing to substantial heterogeneity, a moderate risk of bias, and a low certainty of evidence. Future research should enhance methodological quality by conducting multicenter, large-sample, high-quality RCTs and should explore the long-term effects and cost-effectiveness of mHealth across diverse health care settings and patient populations to clarify its role and value within comprehensive cancer care management systems. Trial Registration: PROSPERO CRD420251162181; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251162181

  • Photorealistic image of clinician using cloud medical imaging to view CT scans. Generated Tamara Capar 30 March 2026. Source: Image created by JMIR; Copyright: N/A - AI-generated image; URL: https://gemini.google.com/app/198e940a9e008a7e; License: Public Domain (CC0).

    Use, Utility, and User Experience of Cloud-Based Medical Imaging in Pulmonary Nodule Care in China: Mixed Methods Study

    Abstract:

    Background: The detection of pulmonary nodules (PNs) has increased with the use of low-dose computed tomography screening. Effective management requires timely longitudinal surveillance and reliable comparison with prior examinations, yet access to previous imaging across institutions is often fragmented, leading to delays and potentially unnecessary repeat scans and costs. Cloud-based medical imaging (CMI) solutions offer a potential means of improving access and facilitating cross-institutional data exchange. However, the adoption and utility of CMI in PN care, especially in China, remain underexplored. Objective: This study aims to evaluate the possession, use, and impact of CMI on health care utilization, patient knowledge, and financial burden, as well as to identify usability and interoperability barriers through qualitative investigation. Methods: A mixed methods cross-sectional study was conducted from October 2022 to May 2024. The study involved 701 patients with PNs who completed structured surveys, and 20 participants (10 patients and 10 physicians) were interviewed. CMI use was defined as self-reported ability to view radiological images on a mobile device. We compared CMI users and nonusers and estimated adjusted odds ratios using multivariable logistic regression, then applied 1:1 propensity score matching to examine associations between CMI use and health care utilization, costs, and patient perceptions, and qualitative interviews were analyzed for usability themes. Results: The study found that 611 (87.2%) out of 701 patients had obtained CMI, with 404 (57.6%) out of 701 patients actively using it. In multivariable analysis, older age was independently associated with lower CMI use (odds ratios 0.985, 95% CI 0.972‐0.999). After 1:1 propensity score matching, CMI users accessed more internet hospitals, consulted more physicians, and reported lower health care costs compared to nonusers. Users also demonstrated higher disease knowledge. Qualitative data identified key barriers, including poor system usability, limited retention time for images, and weak interoperability. CMI was perceived as beneficial for patient convenience and clinical efficiency, though concerns over image quality and system fragmentation were prevalent. Conclusions: While CMI is widely available, its usage remains suboptimal. Increased use is associated with enhanced health care engagement and reduced costs, suggesting that improving system usability and ensuring consistent access to imaging may help realize potential benefits of CMI. Future improvements should focus on ensuring long-term access, better retention protocols, and overcoming interoperability issues.

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  • Exploring the usability of digital behavioral frameworks: Barriers and enablers to applying the Behaviour Change Intervention Ontology and Theories and Techniques Tool in intervention development

    Date Submitted: Mar 31, 2026

    Open Peer Review Period: Apr 1, 2026 - May 27, 2026

    Background: Digital tools are increasingly used to organize, analyze and report behavioral science data, informing interventions addressing health, sustainability and other global challenges. As these...

    Background: Digital tools are increasingly used to organize, analyze and report behavioral science data, informing interventions addressing health, sustainability and other global challenges. As these tools proliferate, there is a need for methods that evaluate their usability, acceptability and influences on uptake, using theory-informed behavioral approaches. Objective: This study aims to explore: (1) the usability and acceptability of the Theory and Techniques Tool (TaTT; tool for intervention development), alongside the Behaviour Change Intervention Ontology (BCIO; a classification framework for behavior change interventions) online tools, and (2) barriers and enablers to using them to specify behavior change techniques (BCTs) and their delivery, using a behavioral model. Methods: Fourteen intervention development experts participated in a think-aloud task using the TaTT and BCIO’s tools to identify BCTs and intervention delivery in a voter-related intervention development scenario. This was followed by interviews to identify barriers and enablers applying the tools, structured around the Capability-Opportunity-Motivation Behaviour (COM-B) Model. Transcripts were analyzed using inductive thematic analysis, and identified barriers and enablers were mapped to COM-B constructs. Results: We identified four usability and acceptability themes: “Information and presentation clarity” (e.g., unclear condensed information); “Navigational ease within and between tools” (e.g., difficulty moving between pages); and “Poor site performance of BCIO tools” (e.g., site crashes) and “Utility of the tools” (e.g., helpful search functions). Four COM-B constructs were identified as barriers and enablers: Psychological capability (e.g., limited knowledge of ontology structure), Physical opportunity (e.g., lack of real-time guidance), Social opportunity (e.g., mixed views on BCIO acceptance) and Reflective motivation (e.g., perceived value of tool). Conclusions: The findings highlight where TaTT and BCIO tools can be improved and where additional guidance is needed. The study also demonstrates a method for exploring usability that can be applied to other digital tools in behavioral sciences. Clinical Trial: N/A

  • Sensitive Topic Detection and Longitudinal Prevalence Tracking in Psychiatric Discharge Summaries: A Retrospective NLP Study

    Date Submitted: Mar 31, 2026

    Open Peer Review Period: Apr 1, 2026 - May 27, 2026

    Background: There is a considerable risk of stigmatization and harm when sensitive topics such as psychiatric diagnoses, substance abuse, and self-harm are recorded in electronic health records, espec...

    Background: There is a considerable risk of stigmatization and harm when sensitive topics such as psychiatric diagnoses, substance abuse, and self-harm are recorded in electronic health records, especially since federal laws like the 21st Century Cures Act now require patients to have access to their own clinical notes. Discharge summaries are particularly problematic since they combine all hospital experiences and perform concurrent administrative, legal, and patient-facing tasks, although they are still not well researched in sensitive topic studies. There is a major methodological vacuum in understanding how the documentation of certain sensitive topics changes over time because current NLP techniques have concentrated on single-topic detection tasks with little attention to prevalence measurement or longitudinal documentation patterns. Objective: To evaluate an NLP based framework for the automated detection of a predefined set of sensitive topics and measuring their change in prevalence over time using the MIMIC-IV database. Methods: Discharge summaries from the MIMIC-IV database were filtered using ICD codes to identify psychiatrically relevant admissions, resulting in 2670 notes from 2108 distinct patients. Both explicit keyword-based and implicit semantic mentions of each sensitive subject category were found using a dual NLP detection framework. Normalized mention counts were used to compute weighted prevalence, which was then examined at the note and patient levels. Fisher’s exact test, McNemar’s exact test, and Benjamin Hochberg FDR correction were used to evaluate temporal change. Results: The weighted prevalence varied across sensitive categories, ranging from 2.68% to 18.93%. Patient level prevalence was consistently higher than note level prevalence across all categories. No statistical significance was observed after FDR correction, suggesting stable documentation over the study period. Improving, worsening, and absent trajectories remained relatively steady independent of overall category predominance, but persistent and mixed documentation patterns showed the most variance among categories, according to trajectory analysis. Conclusions: This study demonstrates the feasibility of a scalable NLP framework for multi-topic sensitive topic detection and prevalence tracking in clinical discharge summaries. The findings highlight the value of combining note-level and patient-level analyzes and provide a foundation for future work examining the impact of policy changes on sensitive topic documentation practices.

  • Mapping Practice-Based Signals of Generative AI in Psychiatric Care: A Qualitative Study of Korean Psychiatrists’ Experiences, Interpretations, and Implementation Priorities

    Date Submitted: Mar 31, 2026

    Open Peer Review Period: Apr 1, 2026 - May 27, 2026

    Background: Generative artificial intelligence (GenAI) has increasingly entered psychiatric practice through patient-facing chatbots, self-help tools, and clinician-facing workflow support. Although p...

    Background: Generative artificial intelligence (GenAI) has increasingly entered psychiatric practice through patient-facing chatbots, self-help tools, and clinician-facing workflow support. Although prior research has examined clinicians’ attitudes, readiness, and anticipated use cases, less is known about how frontline encounters with GenAI shape psychiatrists’ interpretations and implementation priorities. Healthcare foresight also remains methodologically underdeveloped and has focused mainly on external signals, overlooking clinically consequential signals emerging from everyday practice. This gap is especially important in psychiatry, where GenAI-related benefits and harms may depend on patient vulnerability, crisis sensitivity, and the therapeutic relationship. Objective: To qualitatively examine how South Korean psychiatrists described clinical experiences with GenAI, how they interpreted its roles and limits in psychiatric care, and what implementation priorities they emphasized. Selected concepts from horizon-scanning informed the organization of the analysis by orienting attention to practice-based signals, interpretive patterns, and implementation priorities. Methods: In this qualitative descriptive study, directed content analysis and codebook-based thematic synthesis were used to analyze responses to 3 open-ended survey questions administered to members of the Korean Neuropsychiatric Association. Invitations were distributed through the association’s official email system from October 27 to December 26, 2025. The qualitative analysis included respondents who provided an interpretable response to at least 1 item. The questions addressed (1) GenAI-related clinical experiences, (2) perceived advantages and limitations of chatbot-based AI relative to human therapists, and (3) priorities for the safe introduction of GenAI into mental health care. An exploratory participant-level cross-question thematic alignment analysis was also conducted to examine recurring adjacent-item pairings across the experience-interpretation-priority sequence. Results: Of 408 total survey respondents, 311 respondents provided a meaningful response to at least 1 open-ended item. Psychiatrists described GenAI as a clinically ambivalent technology whose implications depended on context, intensity of use, and patient vulnerability. Practice-based signals clustered around patient-led use, clinician-led use, GenAI as a relational object, and GenAI-mediated changes in the patient-clinician interface, with high-risk and destabilizing scenarios cutting across these domains. Experiences ranged from self-help, emotional reflection, triage, and workflow support to overreliance, conflict with clinical authority, reinforcement of distorted or delusion-like beliefs, and suicide- or self-harm-related risk. Respondents viewed GenAI as potentially useful as an adjunct, but also as relationally limited and unacceptable as a replacement for human therapists. Implementation priorities centered on governance, crisis and vulnerability safeguards, technical reliability and clinical validation, and education, supervision, and structural readiness. Cross-question analysis suggested recurrent alignments between frontline signals, a view of GenAI as standardized and tireless but relationally thin, and governance- and validation-oriented implementation priorities. Conclusions: In this qualitative descriptive study, GenAI emerged in psychiatric practice as an access tool, a workflow aid, and, at times, a competing interpretive reference point in clinical encounters. The key implementation challenge is therefore not whether psychiatry will encounter GenAI, but how its use should be bounded, supervised, and governed in light of patient vulnerability, psychiatric risk, and the relational demands of care. Clinical Trial: Clinical Research Information Service (CRIS) KCT0011712; https://cris.nih.go.kr/cris/search/detailSearch.do?seq=32747&search_page=M&search_lang=E&class_yn=

  • Do androids dream of lived experience? A call for human connection in collaborative research amidst the growth of AI

    Date Submitted: Mar 30, 2026

    Open Peer Review Period: Mar 31, 2026 - May 26, 2026

    Professionals, leaders, and institutions in healthcare and health research are rapidly adopting and integrating AI systems and chatbots into their regular work, but this poses risks for patients in th...

    Professionals, leaders, and institutions in healthcare and health research are rapidly adopting and integrating AI systems and chatbots into their regular work, but this poses risks for patients in the case of patient and public involvement and engagement (PPIE). AI offers economical solutions for overstretched health systems and burned-out staff, already shows strengths in speeding up more long-term and minute research practices, and providing unique accessibility accommodations. However, AI can also be used to create personas and virtual PPIE panels, which can speak completely or partially for human patients with lived experience of conditions, thus minimising, distorting, or erasing their voices from collaborative research processes. AI pose risks through several distorting factors, including hallucinations, overconfidence, sycophancy, bias, sexism, and racism. Staley and Barron have argued that learning is the greatest outcome of PPIE. However, if researchers, professionals, and staff use AI chatbots in conjunction with or in lieu of human collaborators, the amount of learning that takes places is greatly reduced, according to AI expert and cultural critic, Ethan Mollick. In conclusion, we provide a checklist to guide professionals and researchers in ethical and responsible uses of AI that preserves the voices and roles of patients, members of the public, and lived experience.

  • Digital Illness Narratives Among Young Chinese Patients With Diabetes: A Thematic Analysis of Social Media Posts

    Date Submitted: Mar 29, 2026

    Open Peer Review Period: Mar 30, 2026 - May 30, 2026

    Background: Chronic illness often disrupts individuals’ everyday lives and sense of self, particularly among young patients navigating identity formation. In the context of expanding digital media,...

    Background: Chronic illness often disrupts individuals’ everyday lives and sense of self, particularly among young patients navigating identity formation. In the context of expanding digital media, online platforms have become important spaces where patients articulate illness experiences and seek support, yet how these processes unfold in non-Western contexts remains underexplored. Objective: This study investigates how young Chinese diabetics negotiate their experiences of diabetes, and reconstruct their identities in response to chronic illness in digital spaces. Methods: A thematic analysis was conducted on 303 narrative posts from RedNote, a Chinese social media platform featuring intimate, user-generated storytelling. Methods: A thematic analysis was conducted on 303 narrative posts from RedNote, a Chinese social media platform featuring intimate, user-generated storytelling. Results: Four narrative types were identified: chaos (cognitive dissonance and disordered life), stigma (social withdrawal and discrimination), resilience (emotional fortitude and self-routinization), and solidarity (familial solidarity and reciprocal digital community). Conclusions: These narratives reveal diverse strategies through which young diabetics manage disruption and regain agency. The study extends biographical disruption theory by conceptualizing disruption as a dynamic, relational process of digital re-storying, offering insights for culturally sensitive health communication and online patient support.

  • Use of Digital Devices and Change in Loneliness over Ten Years: Findings from a Swedish Population-based Longitudinal Study on Aging

    Date Submitted: Mar 30, 2026

    Open Peer Review Period: Mar 30, 2026 - May 25, 2026

    Background: Loneliness is recognized as a global health threat. Older adults are vulnerable to loneliness due to life-changes common in old age. While individual risk factors of loneliness in old age...

    Background: Loneliness is recognized as a global health threat. Older adults are vulnerable to loneliness due to life-changes common in old age. While individual risk factors of loneliness in old age are well-documented, contextual factors are scarcely explored, such as digitalization. Rapid digitalization underscores the need to explore the long-term effect of use of digital devices on loneliness. Objective: To explore whether and how the use of digital devices is associated with changes in loneliness over a ten-year period in a population-based sample of older adults. Methods: Data were obtained from the Swedish Adoption/Twin Study of Aging (SATSA) (N=771; mean age 69.4 years). Digital use use and loneliness was assessed across five waves between 2004 and 2014. Age, sex, education, living situation, self-rated health, and the personality trait openness were assessed at baseline. Growth Mixture Modeling was employed to identify latent trajectories of loneliness, and multinomial logistic regression predicted class membership based on baseline digital use and covariates. Results: Three latent loneliness classes were identified: Class 1 (10.5%; high intercept and significant increases in loneliness), Class 2 (33.2%; intermediate stable loneliness), and Class 3 (56.3%; low stable loneliness). Higher digital use at baseline significantly decreased the odds of belonging to the high-increasing loneliness group (Class 1) compared to the low-stable group (Class 3; OR 0.76, p=0.02, CI: 0.60-0.96). When comparing the two groups with higher loneliness levels (Class 1 vs. Class 2), digital use was the only significant predictor; higher use lowered the odds of experiencing increasing loneliness over time (OR 0.77, p=0.04). Differences between classes were not explained by the personality trait of openness to experience. Conclusions: Higher use of digital devices is associated with lower and more stable levels of loneliness over time. These findings suggest that digital technology might serve as an effective non-invasive tool to combat loneliness in older populations.