Machine Learning Classification of Bipolar Disorder Across Mood States Using Natural Language Processing and Speech Analysis: Observational Study

Yusei Yamaguchi   ¹ , MD ;   Yoshinobu Kano   ² , PhD ;   Genichi Sugihara   ¹ , MD, PhD ;   Ryo Takemura   ³ , PhD ;   Hironobu Nakamura   ¹ , MD, PhD ;   Masaaki Shimizu   ¹ , PhD ;   Mari Iizuka   ⁴ , MD ;   Momoko Kitazawa   ⁵ , PhD ;   Ayako Sento   ⁵ ;   Hidehiko Takahashi   ^{1, 6} , MD, PhD ;   Taishiro Kishimoto   ⁵ , MD, PhD

¹ Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

² Faculty of Informatics, Shizuoka University, Chuo-ku, Hamamatsu, Shizuoka, Japan

³ Clinical and Translational Research Center, Keio University Hospital, Shinjuku-ku, Tokyo, Japan

⁴ Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

⁵ Center for the Promotion of Interdisciplinary Research in Medicine and Life Science, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

⁶ Center for Brain Integration Research, Institute of Science Tokyo, Tokyo, Japan