Improvement of Clinical Practice Guideline Appraisal by Human Experts and AI Agents by Using Structured Guidance: Systematic Review, Meta-Analysis, and Validation Study

Xingrun Mao   ^{1, 2 *} , BS ;   Junhao Wang   ^{3, 4 *} , BS ;   Zezhang Wang   ^{1, 2} , BS ;   Yuwei Zhang   ^{3, 4} , BS ;   Shiyu Qiu   ⁵ , BS ;   Jingyu Ye   ⁵ , BS ;   Shiyan He   ^{1, 2} , BS ;   Chongyang Wang   ^{1, 2} , PhD ;   Yong Xia   ^{1, 2} , PhD ;   Chengqi He   ^{1, 2} , MD ;   Ke Li   ^{3, 4 *} , PhD ;   Siyi Zhu   ^{1, 2 *} , MD

¹ Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

² Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China

³ Center of Statistical Research, School of Statistics and Data Science, Southwestern University of Finance and Economics, Chengdu, Sichuan, China

⁴ Joint Lab of Data Science and Business Intelligence, School of Statistics and Data Science, Southwestern University of Finance and Economics, Chengdu, Sichuan, China

⁵ West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

*these authors contributed equally