Intelligent Framework for Adverse Drug Event Identification Using Large Language Models and Retrieval-Augmented Generation: Development and Evaluation Study

Junlong Ma   ^{1 *} , PhD ;   Xuehong Wu   ^{2 *} , PhD ;   Zeying Feng   ³ , PhD ;   Yun Kuang   ⁴ , PhD ;   Zhendong Ding   ⁵ , PhD ;   Min Li   ² , Prof Dr ;   Guoping Yang   ^{4, 6} , Prof Dr

¹ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China

² School of Computer Science and Engineering, Central South University, Changsha, Hunan, China

³ Clinical Trial Institution Office, Liuzhou Hospital of Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi, China

⁴ Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

⁵ Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

⁶ Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China

*these authors contributed equally