Time-Dynamic AI Models to Predict Quality of Life in Patients With Breast Cancer: Development and Validation Study Using the EORTC BALANCE Cohort

Niclas J Hubel   ¹ , MSc ;   Thijs G W van der Heijden   ² , MSc ;   Benjamin Murauer   ³ , PhD ;   Belle H de Rooij   ^{4, 5} , PhD ;   Kelly M de Ligt   ² , PhD ;   Helena M Verkooijen   ⁶ , Prof Dr ;   Sofie AM Gernaat   ⁶ , PhD ;   Meeke Hoedjes   ⁷ , PhD ;   Volker Arndt   ⁸ , Prof Dr ;   Lonneke V van de Poll-Franse   ^{2, 7} , Prof Dr ;   Bernhard Holzner   ^{1, 3} , Prof Dr ;   Jens Lehmann   ^{1, 9} , PhD

¹ Health Outcomes Research Unit, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria

² Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

³ Evaluation Software Development GmbH, Innsbruck, Austria

⁴ Center of Research on Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands

⁵ Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands

⁶ Division of Imaging and Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands

⁷ Center of Research on Psychological Disorders and Somatic Disorders, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands

⁸ Cancer Survivorship Outcomes and Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

⁹ on behalf of the EORTC Quality of Life Group