Beyond Missingness: Systematizing Methods for Comprehensive Data Fitness Assessment in Clinical Research

Hanieh Razzaghi   ¹ , MPH, PhD ;   Kaleigh Wieand   ¹ , BSc ;   Kimberley L Dickinson   ¹ , MS ;   Michael G Kahn   ² , MD, PhD ;   Jason Roy   ³ , PhD ;   Clair Blacketer   ⁴ , MPH, PMP ;   Dimitri A Christakis   ⁵ , MD, MPH ;   Christopher B Forrest   ¹ , MD, PhD ;   Jane Greenberg   ⁶ , MS, PhD ;   Harold P Lehmann   ⁷ , MD, PhD ;   Keith A Marsolo   ⁸ , PhD ;   Jennifer Sciolla   ⁹ , CTRS, CCLS, MS ;   Mark G Weiner   ¹⁰ , MD ;   Nicole G Weiskopf   ¹¹ , PhD ;   L Charles Bailey   ¹ , MD, PhD

¹ Applied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States

² Analytics Resource Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

³ Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, United States

⁴ Epidemiology Analytics, Janssen Research and Development, Titusville, NJ, United States

⁵ Department of Pediatrics, Seattle Children's Hospital, Seattle, WA, United States

⁶ Department of Information Science, Drexel University, Philadelphia, PA, United States

⁷ Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States

⁸ Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States

⁹ Biomedical Research Informatics Center, Nemours/Alfred I. DuPont Hospital for Children, Wilmington, DE, United States

¹⁰ Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States

¹¹ Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States