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Published on in Vol 28 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/105346, first published .
Asian mother and daughter looking at a smartphone with a cute character app

Real-World Use and Expert-Guided Optimization of a Large Language Model–Based Pediatric Health Assistant: Retrospective Observational Study

Real-World Use and Expert-Guided Optimization of a Large Language Model–Based Pediatric Health Assistant: Retrospective Observational Study

Qiuhong Wei   1, 2, 3, 4, 5 , MD, PhD ;   Li Xiao   1, 6 , MD, PhD ;   Xin Zhang   1 , PhD ;   Hong Wei   7 , MD, PhD ;   Ruijue Wang   1, 8 , MS, MD ;   Suqiao Ou   1 , MS, MD ;   Chao Zhang   9 , MS ;   Huarong Huo   9 , MS ;   Yu Peng   9 , MS ;   Lishen Liu   9 , BS ;   Ping Song   1 * , BS ;   Ziyu Hua   7 * , MD, PhD ;   Ximing Xu   1 * , PhD

1 Big Data Center for Children’s Medical Care, Children’s Hospital of Chongqing Medical University, Chongqing, China

2 Department of Children’s Healthcare, Children’s Hospital of Chongqing Medical University, Chongqing, China

3 National Clinical Research Center for Children and Adolescents’ Health and Diseases, Chongqing, China

4 Intelligent Application of Big Data in Pediatrics Engineering Research Center of Chongqing Education Commission, Chongqing, China

5 Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China

6 Department of Hematology, Children’s Hospital of Chongqing Medical University, Chongqing, China

7 Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing, China

8 Department of Hepatobiliary Surgery, Children’s Hospital of Chongqing Medical University, Chongqing, China

9 Zuoyi Tech, Beijing, China

*these authors contributed equally

Corresponding Author:

  • Ximing Xu, PhD
  • Big Data Center for Children’s Medical Care, Children’s Hospital of Chongqing Medical University
  • No. 20 Jinyu Avenue, Liangjiang New Area
  • Chongqing 401122
  • China
  • Phone: 86 18526547007
  • Email: ximing@hospital.cqmu.edu.cn