Effectiveness of a Digital Therapy on 6-Month Weight Loss in People With Obesity: The Digital Therapy to Promote Weight Loss in Patients With Obesity by Increasing Their Adherence to Treatment (DEMETRA) Randomized Clinical Trial

Simona Bertoli   ^{1, 2} , MD, PhD, Prof Dr ;   Paolo Capodaglio   ^{3, 4} , MD, PhD, Prof Dr Med ;   Santo Colosimo   ^{1, 2} , MD, PhD ;   Ramona Silvana De Amicis   ^{1, 2} , PhD ;   Luisa Gilardini   ¹ , MD ;   Amalia Bruno   ¹ , RD ;   Sara Paola Mambrini   ¹ , PhD ;   Giada Pietrabissa   ^{5, 6} , PhD ;   Luca Cavaggioni   ^{1, 7} , PhD ;   Gianluca Castelnuovo   ^{5, 6 *} , Prof Dr, PhD ;   Giuseppina Piazzolla   ^{8 *} , Prof Dr

¹ Obesity Center and Research Lab on Nutrition and Obesity, IRCCS Istituto Auxologico Italiano, Milan, Italy

² Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy

³ Musculoskeletal and Metabolic Rehabilitation Unit, IRCCS Istituto Auxologico Italiano, Milan, Italy

⁴ Department of Biomedical, Surgical and Dentistry Sciences, University of Milan, Milan, Italy

⁵ Clinical Psychology Research Lab, Piancavallo, IRCCS Istituto Auxologico Italiano, Milan, Italy

⁶ Department of Psychology, Catholic University of Milan, Milan, Italy

⁷ Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy

⁸ University of Bari Aldo Moro, Bari, Italy

*these authors contributed equally