Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study

Jasmin Ziegler   ^{1, 2, 3} , MSc ;   Marcel Pascal Erpenbeck   ¹ , MSc ;   Timo Fuchs   ^{2, 4, 5} , MSc ;   Anna Saibold   ^{2, 6} , MSc ;   Paul-Christian Volkmer   ^{2, 7} , MSc ;   Guenter Schmidt   ^{2, 8} , Dipl.-Ing. (FH) ;   Johanna Eicher   ^{9, 10} , MSc ;   Peter Pallaoro   ^{2, 9, 10} , MSc ;   Renata De Souza Falguera   ^{9, 11} , MSc ;   Fabio Aubele   ¹² , MSc ;   Marlien Hagedorn   ¹² , MSc ;   Ekaterina Vansovich   ^{2, 13} , MSc ;   Johannes Raffler   ^{2, 13} , Dr rer nat ;   Stephan Ringshandl   ¹⁴ , Dr rer nat ;   Alexander Kerscher   ^{2, 3, 7} , Dr med ;   Julia Karolin Maurer   ^{2, 15} , Dr med ;   Brigitte Kühnel   ^{2, 16} , MSc ;   Gerhard Schenkirsch   ^{2, 17} , Dr med ;   Marvin Kampf   ¹ , MSc ;   Lorenz A Kapsner   ^{3, 18} , Dr med ;   Hadieh Ghanbarian   ³ , BEng ;   Helmut Spengler   ^{2, 10} , Dr rer nat ;   Iñaki Soto-Rey   ^{2, 13} , Dr rer med ;   Fady Albashiti   ^{2, 12} , Dr sc hum ;   Dirk Hellwig   ^{2, 4, 5} , Prof Dr ;   Maximilian Ertl   ⁸ , MSc ;   Georg Fette   ⁸ , Dipl. Inf. ;   Detlef Kraska   ¹ , Dr ;   Martin Boeker   ^{2, 9} , Prof Dr ;   Hans-Ulrich Prokosch   ^{1, 2, 3} , Prof Dr ;   Christian Gulden   ^{2, 3} , Dr

¹ Medical Center for Information and Communication Technology, Universitätsklinikum Erlangen, Erlangen, Germany

² Bavarian Cancer Research Center (BZKF), Erlangen, Germany

³ Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

⁴ Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany

⁵ Medical Data Integration Center, University Hospital Regensburg, Regensburg, Germany

⁶ Department of Information Technology, University Hospital Regensburg, Regensburg, Germany

⁷ Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany

⁸ Data Integration Center, University Hospital Würzburg, Würzburg, Germany

⁹ Institute for Artificial Intelligence and Informatics in Medicine, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany

¹⁰ Data Integration Center, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany

¹¹ Section of Precision Psychiatry, Clinic for Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

¹² Medical Data Integration Center, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany

¹³ Digital Medicine, University Hospital of Augsburg, Augsburg, Germany

¹⁴ Department of Medicine, Data Integration Center, Philipps-University Marburg, Marburg, Germany

¹⁵ University Cancer Center Regensburg, University Hospital Regensburg, Regensburg, Germany

¹⁶ Comprehensive Cancer Center Munich, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

¹⁷ Comprehensive Cancer Center Augsburg, University Hospital of Augsburg, Augsburg, Germany

¹⁸ Institute of Radiology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany