Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

Journals

1. Ringeval M, Etindele Sosso F, Cousineau M, Paré G. Advancing Health Care With Digital Twins: Meta-Review of Applications and Implementation Challenges. Journal of Medical Internet Research 2025;27:e69544 View
2. Gilbert S, Drummond D, Cotte F, Ziemssen T. Editorial: Digital twins in medicine—transition from theoretical concept to tool used in everyday care. Frontiers in Digital Health 2025;7 View
3. Samei E, Brenner D. The future of in silico trials and digital twins in medicine. PNAS Nexus 2025;4(5) View
4. Pammi M, Shah P, Yang L, Hagan J, Aghaeepour N, Neu J. Digital twins, synthetic patient data, and in-silico trials: can they empower paediatric clinical trials?. The Lancet Digital Health 2025;7(5):100851 View
5. Kabir M, Shishir F, Shomaji S, Ray S. Digital twins in healthcare IoT: A systematic review. High-Confidence Computing 2025;5(3):100340 View
6. Miedel M, Schurdak M, Stern A, Soto-Gutierrez A, Strobl E, Behari J, Taylor D. Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective. Seminars in Liver Disease 2025 View
7. Tubbs A, Vazquez E. Digital twins in increasing diversity in clinical trials: A systematic review. Journal of Biomedical Informatics 2025;169:104879 View
8. Sharma H, Kaur S. Patient-Specific Digital Twins for Personalized Healthcare: A Hybrid AI and Simulation-Based Framework. IEEE Access 2025;13:143277 View
9. Pérez-Cualtán C, Castro-Páez C, Guerrero-Chalela C, Iaizzo P, Navarro-Rueda J, Briceño J. The role of 3D printing and finite element-based computational simulations in transcatheter pulmonary valve replacement. Progress in Biomedical Engineering 2025;7(4):042007 View
10. Drummond D, van Boven J, Dierick B, Adejumo I, Carroll W, Keyser H, Gaillard E, Chan A. Smart inhalers in paediatric asthma: bridging the gap between innovation and clinical practice. Paediatric Respiratory Reviews 2025 View
11. Abdelhamid T, Huynh N, Zampini S, Chen R, Pavarino L, Scacchi S. Adaptive BDDC preconditioners for the bidomain model on unstructured ventricular finite element meshes. Computer Methods in Applied Mechanics and Engineering 2025;447:118366 View
12. Zou H, Zheng X, Wu L, Zhang S, Chang P, Chen Y. Digital twins in cardiovascular disease: a scoping review. International Journal of Medical Informatics 2026;206:106138 View
13. Eivazzadeh S, Khatibi S. Design of a Predictive Digital Twin System for Large-Scale Varroa Management in Honeybee Apiaries. Agriculture 2025;15(20):2126 View
14. Ahmadasas M, Inanc E, Ozkara E, Siket M, Rashid M, Bilgic M, Quinn L, Cinar A. Cyber–physical–human systems in precision medicine: Advances in artificial pancreas for treatment of diabetes. Annual Reviews in Control 2025;60:101033 View
15. Xuan Z, Niu Y, Wang Y, Wang Z, Zhao J, Chang H, Xiao Q. Perspectives and Preferences on Developing a Digital Human System for Intrinsic Capacity Monitoring Underpinned by World Health Organization’s Integrated Care for Older People Guideline: Qualitative Study. Journal of Medical Internet Research 2025;27:e76222 View
16. Seyedi S, González-Rivas J, Mellacheruvu P, Mellacheruvu A, Aledavood S, Esteghamati A, Mechanick J. Cardiometabolic risk reduction with digital twinning in patients with type 2 diabetes. Cardiovascular Diabetology – Endocrinology Reports 2025;11(1) View
17. Witt C, An J, Christen M. AI, digital twins, and healthcare utilization behaviour: evidence from a Swiss population survey. BMC Health Services Research 2025 View
18. Menon G, Malave B, Mhaske M, Parjane S, Mhaismale H. Digital Twin Technologies in Medicine: The Innovations, Barriers, and Future Directions. Intelligent Hospital 2025:100043 View

Books/Policy Documents

1. Boopathy G, Srinivasan V, Kamalakar V, Chandra Bose G. Accelerating Product Development Cycles With Digital Twins and IoT Integration. View