Precision Medicine

The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study

Jasmin Annica Kuhn-Keller, Ingmar Eiling, Lydiane Hirschler, Lena Václavů, Marie-Noëlle Witjes-Ané, Marjolein Wijngaarden, Martijn Nagtegaal, Ece Ercan, Nathaly Rius Ottenheim, Marjan van der Elst, Evelien Sohl, Mark A van Buchem, Simon Mooijaart, Matthias JP van Osch, Jeroen de Bresser

JMIR Res Protoc 2025 (Dec 04); 14:e77681

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Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation

Samuel Kakraba, Srinivas Ayyadevara, Aayire Yadem Clement, Kuukua Egyinba Abraham, Cesar M Compadre, Robert J Shmookler Reis

JMIR AI 2025 (Dec 03); 4:e77890

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Decentralized Biobanking Pathway to Precision Medicine: Futures Study

Marielle Gross, Ananya Dewan, Kennedy Sabharwal, Amanda Linkous, M Eifler, William Sanchez, Robert Miller, Mario Macis, Joshua C Rubin

J Med Internet Res 2025 (Dec 01); 27:e73965

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Risk Prediction of Major Adverse Cardiovascular Events Within One Year After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: Machine Learning–Based Time-to-Event Analysis

Hong-Jae Choi, Changhee Lee, Hack-Lyoung Kim, Youn-Jung Son

JMIR Med Inform 2025 (Nov 27); 13:e81778

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Toward a Personalized Basal Tuner for Detecting Basal Rate Inaccuracies in Type 1 Diabetes Mellitus Without Meal Data: Algorithm Development and Retrospective Validation Study

Daniel Gasca Garcia, Hood Thabit, Paul W Nutter, Simon Harper

JMIR Diabetes 2025 (Nov 26); 10:e72769

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Effect of Dual-Task Training on Cognitive Function in Community-Dwelling Older Adults With Mild Cognitive Impairment: Sequential Multiple Assignment Randomized Trial

Chenhao Yu, Dongsheng Bian, Jiatao Zhang, Xiao Han, Chenshu Shi, Guohong Li

J Med Internet Res 2025 (Nov 25); 27:e79274

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Estimating 10-Year Cardiovascular Disease Risk in Primary Prevention Using UK Electronic Health Records and a Hybrid Multitask BERT Model: Retrospective Cohort Study

Tianyi Liu, Lei Lu, Yanzhong Wang, Andrew J Krentz, Vasa Curcin

JMIR Med Inform 2025 (Nov 13); 13:e76659

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Generative Models and Sentence Transformers for the Recognition and Normalization of Continuous and Discontinuous Phenotype Mentions: Model Development and Evaluation

Areej Alhassan, Viktor Schlegel, Monira Aloud, Riza Batista-Navarro, Goran Nenadic

JMIR Med Inform 2025 (Nov 05); 13:e68558

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Development and Validation of the Healthy Longevity Index for Personalized Healthy Aging in Primary Care: Cross-National Retrospective Analysis

Hsi-Yu Lai, Shu Zhang, Rei Otsuka, Shih-Tsung Huang, Hidenori Arai, Fei-Yuan Hsiao, Liang-Kung Chen

JMIR Aging 2025 (Nov 03); 8:e80034

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Improving Recruitment Into Research Studies via Electronically Collected Patient-Entered Data: Mixed Methods Study

Irene Katzan, WH Wilson Tang, Andrew Schuster, Ryan Honomichl, Misti Allison, Renee Feldman, Michelle Gandolf, Benjamin Walter, Brittany Lapin

J Med Internet Res 2025 (Oct 29); 27:e77720

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Development and Validation of a Predictive Model for Severe Tubular Atrophy/Interstitial Fibrosis in Patients with IgA Nephropathy: Multicenter Retrospective Study

Caizheng Yu, Zhitong Niu, Qin Fang, Qing Lei

JMIR Med Inform 2025 (Oct 28); 13:e78761

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A Machine Learning–Based Scoring System to Identify High Immunoactivity Microsatellite Stability Tumors by Quantifying Similarity to Microsatellite Instability-High Tumors in Colorectal Cancers: Development and Quantitative Study

Hongkai Yan, Li Jiang, Yaqi Li, Fengchong Wang, Shaobo Mo, Weiqi Sheng, Dan Huang, Junjie Peng

JMIR Form Res 2025 (Oct 16); 9:e66960

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Conversational Artificial Intelligence for Integrating Social Determinants, Genomics, and Clinical Data in Precision Medicine: Development and Implementation Study of the AI-HOPE-PM System

Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal

JMIR Bioinform Biotech 2025 (Oct 10); 6:e76553

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Paired-Sample and Pathway-Anchored MLOps Framework for Robust Transcriptomic Machine Learning in Small Cohorts: Model Classification Study

Mahdieh Shabanian, Nima Pouladi, Liam Wilson, Mattia Prosperi, Yves A Lussier

JMIR Bioinform Biotech 2025 (Oct 08); 6:e80735

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A Series of Personalized Melatonin Supplement Interventions for Poor Sleep: Feasibility Randomized Crossover Trial for Personalized N-of-1 Treatment

Mark J Butler, Thevaa Chandereng, Heejoon Ahn, Stefani Slotnick, Danielle Miller, Alexandra Perrin, Jordyn Rodillas, Ciaran P Friel, Ashley M Goodwin, Ying Kuen Cheung, Karina W Davidson

JMIR Form Res 2025 (Sep 26); 9:e58192

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Clinical Utility of Early Intervention Including the 5-Step Precision Medicine Method in First-Episode Psychosis: Protocol for a Cohort Study With Nested Economic and Process Evaluations

Jesús Pérez, David Heredero Jung, Óscar Gonzalo, Belén García Berrocal, Carmen García Cerdán, Pablo Salas Aranda, Alejandro de la Sota Pérez, Sandra Milagros Lorenzo Hernández, Elena Marcos Vadillo, Rocío García García, Vanesa Berdión Marcos, Ana Maciá Casas, Belén Refoyo Matellán, Berta Bote Bonaechea, Llanyra García Ullán, Carolina Lorenzo Romo, Carmen Martín Gómez, Concha Turrión Gómez, María Isidoro García

JMIR Res Protoc 2025 (Sep 23); 14:e74408

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Machine Learning and Shapley Additive Explanations Value Integration for Predicting the Prognostic of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: Model Development and Evaluation Study

Jia Wang, Haotian Wu, Han Cai, YingXiang Wang, Jian Gu

JMIR Med Inform 2025 (Sep 22); 13:e75020

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Neural Activity Disparities in Deficiency and Excess Patterns of Depression: Protocol for a Systematic Review and Meta-Analysis

Liling Chen, Xinyu Jia, Jianjun Wang, Liling Li, Jianxiang Chen, Songjun Lin, Haotao Zheng, Xinbei Li, Xiude Qin, Lanying Liu, Hanqing Lyu

JMIR Res Protoc 2025 (Sep 18); 14:e68996

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A Design Framework for Microintervention Software Technology in Digital Health: Critical Interpretive Synthesis

Dan Roland Persson, Mel Ramasawmy, Nushrat Khan, Amitava Banerjee, Ann Blandford, Jakob Eyvind Bardram, Per Bækgaard

J Med Internet Res 2025 (Sep 12); 27:e72658

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Small Extracellular Vesicles as Biomarkers in Sarcoma Follow-Up: Protocol for a Prospective, Multicentric Pilot Study

Valentin Vautrot, Alice Hervieu, Aurélie Bertaut, Céline Charon-Barra, Isen Naiken, Sylvain Causseret, Loic Chaigneau, Isabelle Desmoulins, Emilie Rederstoff, Nicolas Isambert, Jessica Gobbo

JMIR Res Protoc 2025 (Sep 09); 14:e63718

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