Published on in Vol 25 (2023)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/46448, first published .
Providing Self-Led Mental Health Support Through an Artificial Intelligence–Powered Chat Bot (Leora) to Meet the Demand of Mental Health Care

Providing Self-Led Mental Health Support Through an Artificial Intelligence–Powered Chat Bot (Leora) to Meet the Demand of Mental Health Care

Providing Self-Led Mental Health Support Through an Artificial Intelligence–Powered Chat Bot (Leora) to Meet the Demand of Mental Health Care

Journals

  1. López-Ojeda W, Hurley R. Medical Metaverse, Part 2: Artificial Intelligence Algorithms and Large Language Models in Psychiatry and Clinical Neurosciences. The Journal of Neuropsychiatry and Clinical Neurosciences 2023;35(4):316 View
  2. Balcombe L. AI Chatbots in Digital Mental Health. Informatics 2023;10(4):82 View
  3. Deps P, Yotsu R, Furriel B, de Oliveira B, de Lima S, Loureiro R. The potential role of artificial intelligence in the clinical management of Hansen’s disease (leprosy). Frontiers in Medicine 2024;11 View
  4. Ridout B, Forsyth R, Amon K, Navarro P, Campbell A. The Urgent Need for an Evidence-Based Digital Mental Health Practice Model of Care for Youth. JMIR Mental Health 2024;11:e48441 View
  5. Laymouna M, Ma Y, Lessard D, Schuster T, Engler K, Lebouché B. Roles, Users, Benefits, and Limitations of Chatbots in Health Care: Rapid Review. Journal of Medical Internet Research 2024;26:e56930 View
  6. Olawade D, Wada O, Odetayo A, David-Olawade A, Asaolu F, Eberhardt J. Enhancing mental health with Artificial Intelligence: Current trends and future prospects. Journal of Medicine, Surgery, and Public Health 2024;3:100099 View
  7. Zhong W, Luo J, Zhang H. The therapeutic effectiveness of artificial intelligence-based chatbots in alleviation of depressive and anxiety symptoms in short-course treatments: A systematic review and meta-analysis. Journal of Affective Disorders 2024;356:459 View
  8. Alhuwaydi A. Exploring the Role of Artificial Intelligence in Mental Healthcare: Current Trends and Future Directions – A Narrative Review for a Comprehensive Insight. Risk Management and Healthcare Policy 2024;Volume 17:1339 View
  9. Merayo N, Ayuso-Lanchares A, González-Sanguino C. Machine learning and natural language processing to assess the emotional impact of influencers’ mental health content on Instagram. PeerJ Computer Science 2024;10:e2251 View
  10. Aditama M, Narosaputra D, Selfiardy S. Integrating digital intelligence into mental health interventions: Problems, evaluation, recommendations. Psychiatry Research 2024;342:116205 View
  11. Pavlopoulos A, Rachiotis T, Maglogiannis I. An Overview of Tools and Technologies for Anxiety and Depression Management Using AI. Applied Sciences 2024;14(19):9068 View
  12. Villanueva M, Wheeler D, Applin S, Hodge T, Zack B, Rebeiro P. Continuous care engagement in clinical practice: perspectives on selected current strategies for people with HIV in the United States. Expert Review of Anti-infective Therapy 2024;22(12):1043 View
  13. Denecke K, Gabarron E. The ethical aspects of integrating sentiment and emotion analysis in chatbots for depression intervention. Frontiers in Psychiatry 2024;15 View
  14. Onciul R, Tataru C, Dumitru A, Crivoi C, Serban M, Covache-Busuioc R, Radoi M, Toader C. Artificial Intelligence and Neuroscience: Transformative Synergies in Brain Research and Clinical Applications. Journal of Clinical Medicine 2025;14(2):550 View
  15. Yuan A, Garcia Colato E, Pescosolido B, Song H, Samtani S. Improving Workplace Well-being in Modern Organizations: A Review of Large Language Model-based Mental Health Chatbots. ACM Transactions on Management Information Systems 2025;16(1):1 View
  16. Rahsepar Meadi M, Sillekens T, Metselaar S, van Balkom A, Bernstein J, Batelaan N. Exploring the Ethical Challenges of Conversational AI in Mental Health Care: Scoping Review. JMIR Mental Health 2025;12:e60432 View
  17. Saleem K, Saleem M, Almogren A, Almogren A, Kaur U, Bharany S, Rehman A. Multi-Agent-Based Cognitive Intelligence in Non-Linear Mental Healthcare-Based Situations. IEEE Access 2025;13:36162 View
  18. Islam S, Shahriyar R, Agarwala A, Zaman M, Ahamed S, Rahman R, Chowdhury M, Sarker F, Mamun K. Artificial intelligence-based risk assessment tools for sexual, reproductive and mental health: a systematic review. BMC Medical Informatics and Decision Making 2025;25(1) View
  19. Park M, Fels S, Seo K. Enhancing academic stress assessment through self-disclosure chatbots: effects on engagement, accuracy, and self-reflection. International Journal of Educational Technology in Higher Education 2025;22(1) View
  20. Chadha S, Mukherjee S, Sanyal S. Advancements and implications of artificial intelligence for early detection, diagnosis and tailored treatment of cancer. Seminars in Oncology 2025;52(3):152349 View
  21. Albikawi Z, Abuadas M, Rayani A. Nursing Students’ Perceptions of AI-Driven Mental Health Support and Its Relationship with Anxiety, Depression, and Seeking Professional Psychological Help: Transitioning from Traditional Counseling to Digital Support. Healthcare 2025;13(9):1089 View
  22. Gamne R, Wajpeyi S, Bobade S. Scope of artificial intelligence in the diagnosis and management of generalized anxiety disorder: A narrative review. Multidisciplinary Reviews 2025;8(10):2025280 View
  23. Chinarev V, Malinina E. The importance of adherence to treatment in the recovery potential of patients with severe forms of schizophrenia. Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) 2025;(5):640 View
  24. Olla P, Barnes A, Elliott L, Abumeeiz M, Olla V, Tan J. Deploying a Mental Health Chatbot in Higher Education: The Development and Evaluation of Luna, an AI-Based Mental Health Support System. Computers 2025;14(6):227 View
  25. Denecke K, Rivera Romero O, Wynn R, Gabarron E. Persuasive chatbot-based interventions for depression: a list of recommendations for improving reporting standards. Frontiers in Psychiatry 2025;16 View
  26. Zhang W, Zhang Q, Wang P, Zhou X, Wu Y. The application of Generative Artificial Intelligence in mental health care: A bibliometric and visualized analysis. Asian Journal of Psychiatry 2025;110:104596 View
  27. Nurtanto M, Adyani A, Nor Abd Aziz M, Umar N, Perdana Sutrisno V, Nawanksari S, Thoharudin M, Ilma A, Kholifah N. Educational Strategies for Addressing Student Anxiety and Depression through Artificial Intelligence: A Bibliometric and Conceptual Analysis. Salud, Ciencia y Tecnología 2025;5:1669 View
  28. Maurya R, Rajput N, Diviit M, Mahapatra S, Ojha M. Exploring the potential of lightweight large language models for AI-based mental health counselling task: a novel comparative study. Scientific Reports 2025;15(1) View
  29. Algumaei A, Yaacob N, Doheir M, Al-Andoli M, Algumaie M. Symmetric Therapeutic Frameworks and Ethical Dimensions in AI-Based Mental Health Chatbots (2020–2025): A Systematic Review of Design Patterns, Cultural Balance, and Structural Symmetry. Symmetry 2025;17(7):1082 View
  30. Chinarev V, Malinina E. The role of adherence to treatment in the recovery potential of patients with severe forms of schizophrenia. Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) 2025;(6):772 View
  31. Akefe I, Adegoke V, Akefe E, Schweitzer D, Bolaji S. An Innovative Approach to Medical Education: Leveraging Generative Artificial Intelligence to Promote Inclusion and Support for Indigenous Students. Trends in Higher Education 2025;4(3):36 View
  32. Cui X, Gu Y, Fang H, Zhu T. Development and evaluation of LLM-based suicide intervention chatbot. Frontiers in Psychiatry 2025;16 View
  33. Espino Carrasco D, Palomino Alcántara M, Arbulú Pérez Vargas C, Santa Cruz Espino B, Dávila Valdera L, Vargas Cabrera C, Espino Carrasco M, Dávila Valdera A, Agurto Córdova L. Sustainability of AI-Assisted Mental Health Intervention: A Review of the Literature from 2020–2025. International Journal of Environmental Research and Public Health 2025;22(9):1382 View
  34. Tomasz Ufniarski , Maria Ufniarska , Aleksandra Piech , Karolina Pasierb , Karol Poplicha , Martyna Grodzińska , Bartłomiej Siuzdak , Justyna Moszkowicz , Piotr Sobkiewicz , Patrycja Kardasz , Marta Jutrzenka , Patrycja Ucieklak . LARGE LANGUAGE MODEL BASED CHATBOTS – A CHANCE FOR CLOSING THE MENTAL HEALTH TREATMENT GAP OR A THREAT TO THE PUBLIC HEALTH? A NARRATIVE REVIEW. International Journal of Innovative Technologies in Social Science 2025;3(3(47)) View
  35. Li S, Zhu G, Peng D, Shen X, Tu C, Meng X, Pai Y, Barbareschi G, Minamizawa K. Introspectus AI: Long-term AI-Driven Dialogue Training To Promote Self-Reflection. Proceedings of the ACM on Human-Computer Interaction 2025;9(7):1 View
  36. Villarreal R, Singhal S, Dempsey A, Shore J. The Future of Digital Mental Health. Psychiatric Clinics of North America 2025 View
  37. Wang Y, Li M, Wang S, Fang Y, Sun J, Lu L, Yan W. Large language models in clinical psychiatry: Applications and optimization strategies. World Journal of Psychiatry 2025;15(11) View
  38. Sun X, Jahangir A, Alghamdi A, Liu F. Use of ai-based mental health tools and psychological well-being among Chinese university students: a parallel mediation model of emotional self-efficacy and perceived autonomy. Scientific Reports 2025;15(1) View
  39. Kuhail M, Al-Shamaileh O, Farooq S, Shahin H, Abdelzaher F, Thomas J, Kaura N. A Systematic Review on Mental Health Chatbots: Trends, Design Principles, Evaluation Methods, and Future Research Agenda. Human Behavior and Emerging Technologies 2025;2025(1) View
  40. Alam A, Shah S, Rabbani S, El-Tanani M. The Role of Artificial Intelligence in Pharmacy Practice and Patient Care: Innovations and Implications. BioMedInformatics 2025;5(4):65 View
  41. Khanh Son N, Sangaiah A, Paramarthika L, Rajendran V, Bian G, Alenazi M. Leveraging AI for Mental Healthcare in Social Fintech: A Multilingual Evaluation of Large Language Models. IEEE Transactions on Computational Social Systems 2025;12(6):5291 View

Books/Policy Documents

  1. Verma P, Rao C, Chapalamadugu P, Tiwari R, Upadhyay S. Next-Generation Cybersecurity. View
  2. Garg M. Spiritual Artificial Intelligence (SAI). View
  3. Wu L. Chatbots and Mental Healthcare in Psychology and Psychiatry. View
  4. Rani J, Mitra B. Improving Academic Performance and Achievement With Inclusive Learning Practices. View
  5. Tumbala Gutti T, Sharma K, Kumar S, Sharma A. Smart Trends in Computing and Communications. View
  6. Plafky C, Badertscher H. Künstliche Intelligenz in der Sozialen Arbeit. View
  7. Plafky C, Badertscher H. Künstliche Intelligenz in der Sozialen Arbeit. View
  8. Choudhury R, Roy P. Revolutionizing Digital Healthcare Through Artificial Intelligence and Automation. View

Conference Proceedings

  1. Manoharan G, Pant L, Tewari R, Vichare S, Sarkar P, Dhanraj J. 2024 7th International Conference on Contemporary Computing and Informatics (IC3I). AI-Powered Chatbots for Mental Health Support View
  2. Baniya A, George A, Jose A, M. S. 2025 International Conference on Multi-Agent Systems for Collaborative Intelligence (ICMSCI). EquiMood: Elevating Emotional Wellness for College Students Through the Power of Machine Learning View
  3. K V, R R, Milinda R, S T. 2025 International Conference on Computational, Communication and Information Technology (ICCCIT). AI-Powered Mental Health Assessment using Emotion Detection for Real-Time Analysis View
  4. Irfan S, Dhivya G, Raghavendran N, Babu M, Jasperline T, Saravanakumar R. 2025 International Conference on Data Science, Agents & Artificial Intelligence (ICDSAAI). AI Personalized Mental Health Monitoring System using Machine Learning, and Natural Language Processing View
  5. Natania S, Juliet S, Ebenezer S. 2025 Third International Conference on Augmented Intelligence and Sustainable Systems (ICAISS). Real-Time Mental Health Prediction Using An AI Chatbot Powered By SVM View
  6. Asisof A. Proceedings of the 2025 International ACM SIGIR Conference on Innovative Concepts and Theories in Information Retrieval (ICTIR). Retrieving Under Uncertainty: Towards a Chatbot Uncertainty Taxonomy (CUT) for Information Retrieval View
  7. Zim M, Hanif M. 2025 6th International Conference on Recent Advances in Information Technology (RAIT). Predictive Analytics in Mental Health: AI for Identifying Risk Factors and Preventing Crises View