This paper is in the following e-collection/theme issue:

Digital Health Reviews (1519) Mobile Health in Psychiatry (478) Web-based and Mobile Health Interventions (3629) Mobile Health (mhealth) (3153) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (1803) Anxiety and Stress Disorders (1179) Depression and Mood Disorders; Suicide Prevention (1515) Chatbots and Conversational Agents (627)

Published on in Vol 25 (2023)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/43862, first published .
Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials

Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials

Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials

Authors of this article:

Yuhao He1, 2 Author Orcid Image ;   Li Yang1, 2 Author Orcid Image ;   Chunlian Qian1, 2 Author Orcid Image ;   Tong Li1, 2 Author Orcid Image ;   Zhengyuan Su1, 2 Author Orcid Image ;   Qiang Zhang3 Author Orcid Image ;   Xiangqing Hou1, 2 Author Orcid Image
Article Authors Cited by (50) Tweetations (4) Metrics

Journals

  1. Garcia Valencia O, Suppadungsuk S, Thongprayoon C, Miao J, Tangpanithandee S, Craici I, Cheungpasitporn W. Ethical Implications of Chatbot Utilization in Nephrology. Journal of Personalized Medicine 2023;13(9):1363 View
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  7. Ulrich S, Gantenbein A, Zuber V, Von Wyl A, Kowatsch T, Künzli H. Development and Evaluation of a Smartphone-Based Chatbot Coach to Facilitate a Balanced Lifestyle in Individuals With Headaches (BalanceUP App): Randomized Controlled Trial. Journal of Medical Internet Research 2024;26:e50132 View
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  14. Zhong W, Luo J, Zhang H. The therapeutic effectiveness of artificial intelligence-based chatbots in alleviation of depressive and anxiety symptoms in short-course treatments: A systematic review and meta-analysis. Journal of Affective Disorders 2024;356:459 View
  15. Ferrario A, Sedlakova J, Trachsel M. The Role of Humanization and Robustness of Large Language Models in Conversational Artificial Intelligence for Individuals With Depression: A Critical Analysis. JMIR Mental Health 2024;11:e56569 View
  16. Chen J, Li C, An K, Dong X, Liu J, Wu H. Effectiveness of telemedicine on common mental disorders: An umbrella review and meta-meta-analysis. Computers in Human Behavior 2024;159:108325 View
  17. Ulrich S, Lienhard N, Künzli H, Kowatsch T. A Chatbot-Delivered Stress Management Coaching for Students (MISHA App): Pilot Randomized Controlled Trial. JMIR mHealth and uHealth 2024;12:e54945 View
  18. Sari A, Widiyarta A. Efektivitas Program Perpustakaan Digital “dJatim” Pada Provinsi Jawa Timur. Indonesian Journal of Public Administration Review 2024;1(4):11 View
  19. Wu P, Summers C, Panesar A, Kaura A, Zhang L. AI Hesitancy and Acceptability—Perceptions of AI Chatbots for Chronic Health Management and Long COVID Support: Survey Study. JMIR Human Factors 2024;11:e51086 View
  20. Khorev V, Kiselev A, Badarin A, Antipov V, Drapkina O, Kurkin S, Hramov A. Review on the use of AI-based methods and tools for treating mental conditions and mental rehabilitation. The European Physical Journal Special Topics 2024 View
  21. Heissler R, Jonáš J, Carre N, Mostovoy K, Bunge E, McDaniel B. Can AI Digital Personas for Well‐Being Provide Social Support? A Mixed‐Method Analysis of User Reviews. Human Behavior and Emerging Technologies 2024;2024(1) View
  22. Sanjeewa R, Iyer R, Apputhurai P, Wickramasinghe N, Meyer D. Empathic Conversational Agent Platform Designs and Their Evaluation in the Context of Mental Health: Systematic Review. JMIR Mental Health 2024;11:e58974 View
  23. Roehrer E, Pokawinkoon P, Watters P, Sauer J, Scanlan J. Adolescent-Centric Design of an Online Safety Chatbot. Journal of Computer Information Systems 2024:1 View
  24. Yu H, Fan L, Li L, Zhou J, Ma Z, Xian L, Hua W, He S, Jin M, Zhang Y, Gandhi A, Ma X. Large Language Models in Biomedical and Health Informatics: A Review with Bibliometric Analysis. Journal of Healthcare Informatics Research 2024;8(4):658 View
  25. Kotov A, Idalski Carcone A, Towner E. Neural Conversational Agent for Weight Loss Counseling: Protocol for an Implementation and Feasibility Study. JMIR Research Protocols 2024;13:e60361 View
  26. Frischholz K, Tanaka H, Shidara K, Onishi K, Nakamura S. Examining the Effects of Cognitive Behavioral Therapy With a Virtual Agent on User Motivation and Improvement in Psychological Distress and Anxiety: Two-Session Experimental Study. JMIR Formative Research 2024;8:e55234 View
  27. Siddals S, Torous J, Coxon A. “It happened to be the perfect thing”: experiences of generative AI chatbots for mental health. npj Mental Health Research 2024;3(1) View
  28. Asanov A, Asanov I, Buenstorf G. A low-cost digital first aid tool to reduce psychological distress in refugees: A multi-country randomized controlled trial of self-help online in the first months after the invasion of Ukraine. Social Science & Medicine 2024;362:117442 View
  29. Zhang Z, Wang J. Can AI replace psychotherapists? Exploring the future of mental health care. Frontiers in Psychiatry 2024;15 View
  30. Yuan J, Peng X, Liu Y, Wang Q. “Don't look at me!”: The role of avatars' presentation style and gaze direction in social chatbot design. Computers in Human Behavior 2025;164:108501 View
  31. Langhammer T, Hilbert K, Wasenmueller R, Praxl B, Ertle A, Asbrand J, Lueken U, Liu X. Evaluation of a CBT‐Based Program for Mental Health in the General Population During the COVID‐19 Pandemic: A Stepped‐Care Approach Using a Chatbot and Digitized Group Intervention. Depression and Anxiety 2024;2024(1) View
  32. Koltcov S, Surkov A, Koltsova O, Ignatenko V. Using large language models for extracting and pre-annotating texts on mental health from noisy data in a low-resource language. PeerJ Computer Science 2024;10:e2395 View
  33. Leung W, Lam S, Ng F, Yip C, Chan C. Effectiveness of chatbot-based interventions on mental well-being of the general population in Asia: protocol for a systematic review and meta-analysis of randomised controlled trials. BMJ Health & Care Informatics 2024;31(1):e101148 View
  34. Foran H, Kubb C, Mueller J, Poff S, Ung M, Li M, Smith E, Akinyemi A, Kambadur M, Waller F, Graf M, Boureau Y. An Automated Conversational Agent Self-Help Program: Randomized Controlled Trial. Journal of Medical Internet Research 2024;26:e53829 View
  35. Park J, Singh V, Wisniewski P. Current Landscape and Future Directions for Mental Health Conversational Agents for Youth: Scoping Review. JMIR Medical Informatics 2025;13:e62758 View
  36. Yang Q, Cheung K, Zhang Y, Zhang Y, Qin J, Xie Y. Conversational agents in physical and psychological symptom management: A systematic review of randomized controlled trials. International Journal of Nursing Studies 2025;163:104991 View
  37. Sobowale K, Humphrey D. Evaluating the Quality of Psychotherapy Conversational Agents: Framework Development and Cross-Sectional Study (Preprint). JMIR Formative Research 2024 View
  38. Rządeczka M, Sterna A, Stolińska J, Kaczyńska P, Moskalewicz M. The Efficacy of Conversational AI in Rectifying the Theory-of-Mind and Autonomy Biases: Comparative Analysis. JMIR Mental Health 2025;12:e64396 View
  39. Tekin Ş, Delehanty M. Beyond Doomsday Fears: Why We Need to Consider the Potential Harms of AI Psychotherapy. The American Journal of Bioethics 2025:1 View
  40. Wu X, Liew K, Dorahy M. Trust, Anxious Attachment, and Conversational AI Adoption Intentions in Digital Counseling: A Preliminary Cross-Sectional Questionnaire Study. JMIR AI 2025;4:e68960 View
  41. Escoredo M, Mostovoy K, Schickler R, Bechtel A, Shagan J, Bunge E. Enhancing parental skills through artificial intelligence‐based conversational agents: The PAT Initiative. Family Relations 2025 View
  42. MacNeill A, Luke A, Doucet S. Individual differences in views toward healthcare conversational agents: A cross-sectional survey study. DIGITAL HEALTH 2025;11 View
  43. Rony M, Das D, Khatun M, Ferdousi S, Akter M, Khatun M, Begum M, Khalil M, Parvin M, Alrazeeni D, Akter F. Artificial intelligence in psychiatry: A systematic review and meta-analysis of diagnostic and therapeutic efficacy. DIGITAL HEALTH 2025;11 View
  44. Feng Y, Hang Y, Wu W, Song X, Xiao X, Dong F, Qiao Z. Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis. Journal of Medical Internet Research 2025;27:e69639 View
  45. Wang R, Zhang X, Zhu L, Teng H, Zhang D, Qiu B. The Double-Edged Sword Effect of Empathic Concern on Mental Health and Behavioral Outcomes: The Mediating Role of Excessive Adaptation. Behavioral Sciences 2025;15(4):463 View
  46. Huang Y, Wang W, Zhou J, Zhang L, Lin J, Liu H, Hu X, Zhou Z, Dong W. Integrative modeling enables ChatGPT to achieve average level of human counselors performance in mental health Q&A. Information Processing & Management 2025;62(5):104152 View
  47. Zhang Z, Sun S, Moradbakhti L, Hall A, Mougenot C, Chen J, Calvo R. Health Care Professionals' Engagement With Digital Mental Health Interventions in the United Kingdom and China: Mixed Methods Study on Engagement Factors and Design Implications. JMIR Mental Health 2025;12:e67190 View
  48. Teo J, Yoong S, Chan Y, Jiang Y. The Effects of Commercial Conversational Agents on Older Adults’ Mental Health: A Scoping Review. Journal of the American Medical Directors Association 2025;26(6):105523 View

Books/Policy Documents

  1. de Bruijn G, Jabeen F, Bosse T. The Handbook of Mental Health Communication. View

Conference Proceedings

  1. Vieira Sousa J, Campos P, Bala P. Proceedings of the 27th International Academic Mindtrek Conference. College Tales: Pilot Study on Large Language Models Generated Narratives for Mental Health Literacy View