Assessing Patient Adherence to and Engagement With Digital Interventions for Depression in Clinical Trials: Systematic Literature Review

Journals

1. van Mierlo T, Rondina R, Fournier R. Nudges and Prompts Increase Engagement in Self-Guided Digital Health Treatment for Depression and Anxiety: Results From a 3-Arm Randomized Controlled Trial. JMIR Formative Research 2024;8:e52558 View
2. Okoye V, Okoye G, Appiah D. Harnessing Digital Health Solutions to Enhance Medication Adherence in Patients With Depression. Innovations in Digital Health, Diagnostics, and Biomarkers 2024;4(2024):9 View
3. King Jr V, Siegel G, Priesmeyer H, Siegel L, Potter J. Development and Evaluation of a Digital App for Patient Self-Management of Opioid Use Disorder: Usability, Acceptability, and Utility Study. JMIR Formative Research 2024;8:e48068 View
4. Woolley M, Klimczak K, Davis C, Levin M. Predictors of adherence to a publicly available self-guided digital mental health intervention. Cognitive Behaviour Therapy 2024;53(6):577 View
5. Cuomo A, Aguglia A, De Berardis D, Ventriglio A, Gesi C, Fagiolini A. Individualized strategies for depression: narrative review of clinical profiles responsive to vortioxetine. Annals of General Psychiatry 2024;23(1) View
6. Tomás J, Velasco A, Mínguez S. Aplicaciones móviles para mejorar el cumplimiento terapéutico. FMC - Formación Médica Continuada en Atención Primaria 2024;31(6):326 View
7. Gray L, Marcynikola N, Barnett I, Torous J. The Potential for Digital Phenotyping in Understanding Mindfulness App Engagement Patterns: A Pilot Study. Journal of Integrative and Complementary Medicine 2024;30(11):1108 View
8. Kamdar M, Jethwani K, Centi A, Agboola S, Fischer N, Traeger L, Rinaldi S, Strand J, Ritchie C, Temel J, Greer J, Kvedar J, El-Jawarhi A, Jackson V. A Digital Therapeutic Application (ePAL) to Manage Pain in Patients With Advanced Cancer: A Randomized Controlled Trial. Journal of Pain and Symptom Management 2024;68(3):261 View
9. Rothman B, Slomkowski M, Speier A, Rush A, Trivedi M, Lawson E, Fahmy M, Carpenter D, Chen D, Forbes A. Evaluating the Efficacy of a Digital Therapeutic (CT-152) as an Adjunct to Antidepressant Treatment in Adults With Major Depressive Disorder: Protocol for the MIRAI Remote Study. JMIR Research Protocols 2024;13:e56960 View
10. Fitzsimmons‐Craft E, Rackoff G, Shah J, Strayhorn J, D'Adamo L, DePietro B, Howe C, Firebaugh M, Newman M, Collins L, Taylor C, Wilfley D. Effects of Chatbot Components to Facilitate Mental Health Services Use in Individuals With Eating Disorders Following Online Screening: An Optimization Randomized Controlled Trial. International Journal of Eating Disorders 2024;57(11):2204 View
11. Kerna N, Holets H, Kadivi K, Pruitt K, Carsrud N, Jomsky B, Ngwu D, Flores J, Nwokorie U, Anderson II J, Morvey S, Azi C, Nnake I, Egli A, Ikokwu O, Adadzi J. Balancing Placebo Use with Evidence-Based Treatments: The Placebo Effect in Clinical Practice and Research. European Journal of Medical and Health Research 2024;2(5):107 View
12. Dwyer B, Flathers M, Burns J, Mikkelson J, Perlmutter E, Chen K, Ram N, Torous J. Assessing Digital Phenotyping for App Recommendations and Sustained Engagement: Cohort Study. JMIR Formative Research 2024;8:e62725 View
13. Park Y, Guevarra D, Simon-Thomas E, Epel E. Who engages in well-being interventions? An analysis of a global digital intervention study. The Journal of Positive Psychology 2025;20(4):699 View
14. Lau C, Saad A, Camara B, Rahman D, Bolea-Alamanac B. Acceptability of Digital Mental Health Interventions for Depression and Anxiety: Systematic Review. Journal of Medical Internet Research 2024;26:e52609 View
15. Talay L, Vickers M. Why People Seek Obesity Care Through Digital Rather Than In-Person Services: A Quantitative Multinational Analysis of Patients From a Large Unsubsidized Digital Obesity Provider. Cureus 2024 View
16. Jonassaint C, Lalama C, Carroll C, Badawy S, Hamm M, Stinson J, Lalloo C, Saraf S, Gordeuk V, Cronin R, Shah N, Lanzkron S, Liles D, O’Brien J, Trimnell C, Bailey L, Lawrence R, Saint Jean L, DeBaun M, De Castro L, Palermo T, Abebe K. Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease. Blood Advances 2024;8(24):6257 View
17. Zainal N, Benjet C, Albor Y, Nuñez‐Delgado M, Zambrano‐Cruz R, Contreras‐Ibáñez C, Cudris‐Torres L, de la Peña F, González N, Guerrero‐López J, Gutierrez‐Garcia R, Jiménez‐Peréz A, Medina‐Mora M, Patiño P, Cuijpers P, Gildea S, Kazdin A, Kennedy C, Luedtke A, Sampson N, Petukhova M, Zubizarreta J, Kessler R. Statistical methods to adjust for the effects on intervention compliance in randomized clinical trials where precision treatment rules are being developed. International Journal of Methods in Psychiatric Research 2025;34(1) View
18. Eisner E, Faulkner S, Allan S, Ball H, Di Basilio D, Nicholas J, Priyam A, Wilson P, Zhang X, Bucci S. Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis. JMIR Mental Health 2025;12:e65246 View
19. Reuther C, von Essen L, Mustafa M, Saarijärvi M, Woodford J. Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the ENGAGE Feasibility Trial. JMIR Formative Research 2025;9:e67171 View
20. Benjet C, Zainal N, Albor Y, Alvis-Barranco L, Carrasco Tapia N, Contreras-Ibáñez C, Cortés-Morelos J, Cudris-Torres L, de la Peña F, González N, Gutierrez-Garcia R, Vargas-Contreras E, Medina-Mora M, Patiño P, Gildea S, Kennedy C, Luedtke A, Sampson N, Petukhova M, Zubizarreta J, Cuijpers P, Kazdin A, Kessler R. The Effect of Predicted Compliance With a Web-Based Intervention for Anxiety and Depression Among Latin American University Students: Randomized Controlled Trial. JMIR Mental Health 2025;12:e64251 View
21. Madrid‐Cagigal A, Kealy C, Potts C, Mulvenna M, Byrne M, Barry M, Donohoe G. Digital Mental Health Interventions for University Students With Mental Health Difficulties: A Systematic Review and Meta‐Analysis. Early Intervention in Psychiatry 2025;19(3) View
22. Trache D, Șerbănoiu L, Bistriceanu M, Olteanu G, Andronic O, Călin L, Busnatu Ș. Cardiac Telerehabilitation After Heart Attack Using E-Learning Platforms and Monitoring Cardiovascular Risk Factors: A Narrative Review of the Literature. Medicina 2025;61(4):635 View
23. Chanagala B, Chauhan S, Fisher S, Hoffman M, Frasch M, Ayatollahi H. Perinatal mental health care goes digital: Opportunities for digital health to revolutionize the care delivery for healthier pregnancies and outcomes. PLOS Digital Health 2025;4(4):e0000773 View
24. Cronin R, Quaye N, Liu X, Landes K, Crosby L, Kassim A, DeBaun M, Schnell P. Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial. JMIR Formative Research 2025;9:e67906 View
25. Pu Y, Zhang G, You S, Gains H, Huang K, Jiao Y, He R, Han B, Yang H, Jia Y, Chen L. Reminiscence therapy delivery formats for older adults with dementia or mild cognitive impairment: A systematic review and network meta-analysis. International Journal of Nursing Studies 2025;168:105085 View
26. Vavani B, van Luenen S, Garnefski N, Spinhoven P, Amone-P’Olak K, Witlox M, Kraaij V. The effectiveness of self-help interventions in the treatment of depressive symptoms in low-and-middle-income countries (LMICs): a meta-analysis. International Journal of Mental Health 2025:1 View
27. Rothman B, Slomkowski M, Speier A, Rush A, Trivedi M, Lakhan S, Lawson E, Fahmy M, Carpenter D, Chen D, Docherty J, Forbes A. A digital therapeutic (CT-152) as adjunct to antidepressant medication: A phase 3 randomized controlled trial (the Mirai study). Journal of Affective Disorders 2025;388:119409 View
28. Kim H, Choi Y. Developing interactive VR-based digital therapeutics for Acceptance and Commitment Therapy (ACT): a structured framework for the digital transformation integrating gamification and multimodal arts. Frontiers in Psychiatry 2025;16 View
29. Catalogna M, Saporta N, Nathansohn-Levi B, Tamir T, Shahaf A, Molcho S, Erlich S, Shelly S, Amedi A. Mobile application leads to psychological improvement and correlated neuroimmune function change in subjective cognitive decline. npj Digital Medicine 2025;8(1) View
30. Smith K, Ward T, Lambe S, Ostinelli E, Blease C, Gant T, Gold S, Holmes E, Paccoud I, Vinnikova A, Klucken J, Uhlhaas P, Sanchez C, Haining K, Böge K, Lahutina S, Tomelleri L, Ryan S, Torous J, Cipriani A. Engagement and attrition in digital mental health: current challenges and potential solutions. npj Digital Medicine 2025;8(1) View
31. Ravandi B, Khan I, Markelius A, Bergström M, Gander P, Erzin E, Lowe R. Exploring task and social engagement in companion social robots: a comparative analysis of feedback types. Advanced Robotics 2025;39(14):884 View
32. Klimczak K, Twohig M, Peacock G, Levin M. Mechanisms of change in peer coaching for digital ACT: A serial mediation model on program adherence and psychological flexibility's role in reducing distress. Journal of Contextual Behavioral Science 2025;37:100922 View
33. Kershaw S, Deng J, Keaveny M, Speirs B, Grager A, Sampson D, Ross K, Newton N, Teeson M, Kay-Lambkin F, Chapman C. A Web-Based Well-Being and Resilience Intervention for Family Members and Friends Supporting a Loved One Using Alcohol and Other Drugs: Mixed Methods Pilot Study. JMIR Formative Research 2025;9:e72425 View
34. Zarski A, Sextl-Plötz T, Schmidt-Hantke J, Hess N, Buntrock C. Participatory development and proof-of-concept of a dyadic-based, AI-driven, just-in-time adaptive intervention mechanism for preventing anxiety and depressive disorders via app: study protocol for a feasibility study. Frontiers in Public Health 2025;13 View
35. Jin Y, Wang H, Song J. Gut-brain axis modulation in remote rehabilitation of Parkinson’s disease: reconstructing the fecal metabolome and nigral network connectivity. Frontiers in Neurology 2025;16 View
36. Zainal N, Wang V, Garthwaite B, Curtiss J. What factors are related to engagement with digital mental health interventions (DMHIs)? A meta-analysis of 117 trials. Health Psychology Review 2025:1 View
37. Schwarz J, Chen K, Dashti H, Heinze M, Schönbeck J, Schubert D, Senst B, Speck J, Torous J, Wolff J, Uchtmann L, Meier-Diedrich E. Piloting Digital Navigators to Promote Acceptance and Engagement With Digital Mental Health Apps in German Outpatient Care: Protocol for a Multicenter, Single-Group, Observational, Mixed Methods Interventional Study (DigiNavi). JMIR Research Protocols 2025;14:e67655 View
38. Soini T, Andersson F, Lalouni M, Bonnert M, Voghera S, Ljótsson B, Benninga M, Vlieger A, Rolandsdotter H, Uusijärvi A, Olén O. Hypnotherapy self-exercises with audio files for children and adolescents with disorders of gut-brain interaction—a study of feasibility and preliminary effects in Sweden. Therapeutic Advances in Gastroenterology 2025;18 View
39. Qian Y, Tang W, Xu T, Zhu D, Hua W. Emotional support powered by artificial intelligence in healthcare settings: A scoping review of technologies, contents, and outcomes. International Journal of Nursing Studies 2025;172:105243 View
40. Ren W, Xue X, Liu L, Huang J. AI Applications in Depression Detection and Diagnosis: Bibliometric and Visual Analysis of Trends and Future Directions. JMIR Mental Health 2025;12:e79293 View
41. Mason M, Coatsworth J, Brown A, Zaharakis N, Russell M, Mennis J. Treating young adult generalized anxiety disorder with text-message delivered cognitive behavioral therapy: A randomized clinical trial testing efficacy and clinical mechanisms. Journal of Anxiety Disorders 2025;116:103089 View
42. Abi Ramia J, Khoury S, Armani N, Cuijpers P, Carswell K, van ‘t Hof E, Zoghbi E, Sijbrandij M, El Chammay R. From research to real-life implementation: an evaluation of the scale up of a guided digital mental health intervention in Lebanon: Step-by-Step. Frontiers in Public Health 2025;13 View
43. Figueiredo T, Alcântara L, Carrilho J, Paúl C, Costa E. Understanding Adherence to Digital Health Technologies: Systematic Review of Predictive Factors. Journal of Medical Internet Research 2025;27:e77362 View
44. Linardon J, Torous J, Messer M, Liu C, Bell I, Nicholas J, Goldberg S. Association between user engagement and clinical outcomes in smartphone apps for depression and anxiety: A systematic review and meta-analysis. Psychiatry Research 2026;355:116864 View

Books/Policy Documents

1. Drüge M, Guthardt L, Haller E, Michalak J, Apolinário-Hagen J. Recent Advances and Challenges in the Treatment of Major Depressive Disorder. View

Conference Proceedings

1. Chau C, Norton C, Kruzan K, Jacobs M. Proceedings of the 2025 CHI Conference on Human Factors in Computing Systems. "All Day, Every Day, Listening to Trauma": Investigating Features of Digital Interventions for Empathy-Based Stress and Burnout View