Effectiveness of Using Virtual Reality–Supported Exercise Therapy for Upper Extremity Motor Rehabilitation in Patients With Stroke: Systematic Review and Meta-analysis of Randomized Controlled Trials

Journals

1. Pillai A, Sunny M, Shahria M, Banik N, Rahman M. Gamification of Upper Limb Rehabilitation in Mixed-Reality Environment. Applied Sciences 2022;12(23):12260 View
2. Lee K, Kim H, Choe K, Cho A, Kim B, Seo J, Myung W, Park J, Oh K. Effects of Fetal Images Produced in Virtual Reality on Maternal-Fetal Attachment: Randomized Controlled Trial. Journal of Medical Internet Research 2023;25:e43634 View
3. Ross R, Hart E, Williams E, Gregory C, Flume P, Mingora C, Woodbury M. Combined Aerobic Exercise and Virtual Reality-Based Upper Extremity Rehabilitation Intervention for Chronic Stroke: Feasibility and Preliminary Effects on Physical Function and Quality of Life. Archives of Rehabilitation Research and Clinical Translation 2023;5(1):100244 View
4. Guo Q, He L, Su W, Tan H, Han L, Gui C, Chen Y, Jiang H, Gao Q. Virtual reality for neurorehabilitation: A bibliometric analysis of knowledge structure and theme trends. Frontiers in Public Health 2022;10 View
5. Kashoo F, Al-Baradie R, Alzahrani M, Alanazi A, Manzar M, Gugnani A, Sidiq M, Shaphe M, Sirajudeen M, Ahmad M, Althumayri B, Aljandal A, Almansour A, Alshewaier S, Chahal A. Effect of Transcranial Direct Current Stimulation Augmented with Motor Imagery and Upper-Limb Functional Training for Upper-Limb Stroke Rehabilitation: A Prospective Randomized Controlled Trial. International Journal of Environmental Research and Public Health 2022;19(22):15199 View
6. Naqvi W, Qureshi M, Nimbulkar G, Umate L. Gamification for Distal Radius Fracture Rehabilitation: A Randomized Controlled Pilot Study. Cureus 2022 View
7. Kostenko E, Petrova L, Pogonchenkova I, Kopasheva V. Virtual reality as a technology of multimodal correction of post-stroke motor and cognitive disturbances in conditions of multitasking functioning (literature review). Medical Journal of the Russian Federation 2022;28(5):381 View
8. Chen T, Chen J, Or C, Lo F. Path analysis of the roles of age, self-efficacy, and TAM constructs in the acceptance of performing upper limb exercises through immersive virtual reality games. International Journal of Industrial Ergonomics 2022;91:103360 View
9. Xie Z, Chen J, Or C. Consumers’ Willingness to Pay for eHealth and Its Influencing Factors: Systematic Review and Meta-analysis. Journal of Medical Internet Research 2022;24(9):e25959 View
10. Suprayitno E, Kustiningsih K, Ismail S. Stroke patients' neurorehabilitation. Kontakt 2023;25(2):131 View
11. Moulaei K, Bahaadinbeigy K, Haghdoostd A, Nezhad M, Gheysari M, Sheikhtaheri A. An analysis of clinical outcomes and essential parameters for designing effective games for upper limb rehabilitation: A scoping review. Health Science Reports 2023;6(5) View
12. Lee J, Kim E. The Effect of Diagonal Exercise Training for Neurorehabilitation on Functional Activity in Stroke Patients: A Pilot Study. Brain Sciences 2023;13(5):799 View
13. Sun M, Bai C, Yang D. Exploring the metaverse hospital beyond your imagination. Clinical eHealth 2023;6:53 View
14. Dewil S, Kuptchik S, Liu M, Sanford S, Bradbury T, Davis E, Clemente A, Nataraj R. The cognitive basis for virtual reality rehabilitation of upper-extremity motor function after neurotraumas. Journal on Multimodal User Interfaces 2023;17(3):105 View
15. Carnevale A, Mannocchi I, Schena E, Carli M, Sassi M, Marino M, Longo U. Performance Evaluation of an Immersive Virtual Reality Application for Rehabilitation after Arthroscopic Rotator Cuff Repair. Bioengineering 2023;10(11):1305 View
16. Herrera V, Vallejo D, Castro-Schez J, Monekosso D, de los Reyes A, Glez-Morcillo C, Albusac J. Rehab-Immersive: A framework to support the development of virtual reality applications in upper limb rehabilitation. SoftwareX 2023;23:101412 View
17. Chen T, Or C. Perceptions of a machine learning-based lower-limb exercise training system among older adults with knee pain. DIGITAL HEALTH 2023;9 View
18. Rüth M, Schmelzer M, Burtniak K, Kaspar K. Commercial exergames for rehabilitation of physical health and quality of life: a systematic review of randomized controlled trials with adults in unsupervised home environments. Frontiers in Psychology 2023;14 View
19. Chen J, Or C, Li Z, Yeung E, Zhou Y, Hao T. Effectiveness, safety and patients’ perceptions of an immersive virtual reality–based exercise system for poststroke upper limb motor rehabilitation: A proof-of-concept and feasibility randomized controlled trial. DIGITAL HEALTH 2023;9 View
20. Bargeri S, Scalea S, Agosta F, Banfi G, Corbetta D, Filippi M, Sarasso E, Turolla A, Castellini G, Gianola S. Effectiveness and safety of virtual reality rehabilitation after stroke: an overview of systematic reviews. eClinicalMedicine 2023;64:102220 View
21. Hu Y, Yuan X, Ye P, Chang C, Hu Y, Zhang W, Li K. Virtual Reality in Clinical Nursing Practice Over the Past 10 Years: Umbrella Review of Meta-Analyses. JMIR Serious Games 2023;11:e52022 View
22. Fregna G, Paoluzzi C, Baroni A, Cano-de-la-Cuerda R, Casile A, Straudi S. Head-Mounted Displays for Upper Limb Stroke Rehabilitation: A Scoping Review. Journal of Clinical Medicine 2023;12(23):7444 View
23. Hongmei Z, Jingwei Y. EFFECT OF AEROBIC EXERCISE ON MICROCIRCULATION IN SEDENTARY COLLEGE STUDENTS. Revista Brasileira de Medicina do Esporte 2023;29 View
24. Chen T, Or C. Automated machine learning-based prediction of the progression of knee pain, functional decline, and incidence of knee osteoarthritis in individuals at high risk of knee osteoarthritis: Data from the osteoarthritis initiative study. DIGITAL HEALTH 2023;9 View
25. Marek K, Redlicka J, Miller E, Zubrycki I. Objectivizing Measures of Post-Stroke Hand Rehabilitation through Multi-Disciplinary Scales. Journal of Clinical Medicine 2023;12(23):7497 View
26. Lülsdorff K, Junker F, Studer B, Wittenberg H, Pickenbrock H, Schmidt-Wilcke T. Neurorehabilitation of the upper extremity – immersive virtual reality vs. electromechanically assisted training. A comparative study. Frontiers in Neurology 2023;14 View
27. Kiper P, Godart N, Cavalier M, Berard C, Cieślik B, Federico S, Kiper A, Pellicciari L, Meroni R. Effects of Immersive Virtual Reality on Upper-Extremity Stroke Rehabilitation: A Systematic Review with Meta-Analysis. Journal of Clinical Medicine 2023;13(1):146 View
28. Willingham T, Stowell J, Collier G, Backus D. Leveraging Emerging Technologies to Expand Accessibility and Improve Precision in Rehabilitation and Exercise for People with Disabilities. International Journal of Environmental Research and Public Health 2024;21(1):79 View
29. Lorenz E, Bråten Støen A, Lie Fridheim M, Alsos O. Design recommendations for XR-based motor rehabilitation exergames at home. Frontiers in Virtual Reality 2024;5 View
30. Ali A, Kumaran D, Unni A, Sardesai S, Prabhu V, Nirmal P, Pai A, Guddattu V, Arumugam A. Effectiveness of an Intensive, Functional, and Gamified Rehabilitation Program on Upper Limb Function in People With Stroke (EnteRtain): A Multicenter Randomized Clinical Trial. Neurorehabilitation and Neural Repair 2024;38(4):243 View
31. Hurtado-Olmo P, González-Santos Á, Pérez de Rojas J, Fernández-Martínez N, del Olmo L, Hernández-Cortés P. Surgical Treatment in Post-Stroke Spastic Hands: A Systematic Review. Journal of Clinical Medicine 2024;13(4):945 View
32. Ceccarelli M, Sanz S, Díaz V, Russo M. Design and Construction of a Prototype of an Assisting Device for Arm Exercise. Machines 2024;12(2):145 View
33. Wang L. Effects of semi-immersive virtual reality exercise on the quality of life of community-dwelling older adults: Three-month follow-up of a randomized controlled trial. DIGITAL HEALTH 2024;10 View
34. Prats-Bisbe A, López-Carballo J, García-Molina A, Leno-Colorado D, García-Rudolph A, Opisso E, Jané R. Virtual Reality–Based Neurorehabilitation Support Tool for People With Cognitive Impairments Resulting From an Acquired Brain Injury: Usability and Feasibility Study. JMIR Neurotechnology 2024;3:e50538 View
35. Sales Mendes A, Sánchez San Blas H, Pérez Robledo F, De Paz Santana J, Villarrubia González G. A novel multiagent system for cervical motor control evaluation and individualized therapy: integrating gamification and portable solutions. Multimedia Systems 2024;30(3) View
36. Sharma V, Sharath H, Sasun A. Effectiveness of Syrebo’s Glove Rehabilitation Program in a Patient With Middle Cerebral Artery Infarct: A Case Report. Cureus 2024 View
37. Arya N, Seth N, Raghuveer R, Sewani Y. Exploring the Efficacy of Physiotherapy in Guillain-Barré Syndrome Through Virtual Reality-Based Rehabilitation: A Case Report. Cureus 2024 View
38. Lou J, Li J, Fan Y, Zhang C, Huang N. Effects of Virtual Reality on Analgesia in Wound Care and Physical Therapy for Burn Patients: A Systematic Review and Meta-analysis. Pain Management Nursing 2024;25(4):377 View
39. Bao X, Song X, Deng H, Jiang L. The Impact of Virtual Reality Training Combined with Traditional Chinese Medicine Health Preservation Therapy on Cognitive Function, Neurological Function, and Physical Function of Stroke Patients. International Journal of Neuroscience 2024:1 View
40. Soleimani M, Ghazisaeedi M, Heydari S. The efficacy of virtual reality for upper limb rehabilitation in stroke patients: a systematic review and meta-analysis. BMC Medical Informatics and Decision Making 2024;24(1) View
41. Isbel S, Holloway H, Greber C, Nguyen K, Frost J, Pearce C, D’Cunha N. Virtual reality after stroke: Identifying important characteristics when designing experiences to improve engagement in upper limb rehabilitation. DIGITAL HEALTH 2024;10 View
42. Diriba Kenea C, Gemechu Abessa T, Lamba D, Bonnechère B. Technological Features of Immersive Virtual Reality Systems for Upper Limb Stroke Rehabilitation: A Systematic Review. Sensors 2024;24(11):3546 View
43. Carlos B, Menezes L, Rosa B, Furumoto B, Feitosa S, Fernandes C, Ferreira-Melo S, Pereira J, Almeida S, Brandão A, Ruas C, Castellano G. Graph network and symmetry analysis after combined XR and tDCS in stroke rehabilitation. Biomedical Signal Processing and Control 2024;96:106499 View
44. Chen T, Chen J, Or C. Heuristic evaluation and end-user testing of a machine learning-based lower-limb exercise training system for management of knee pain in individuals aged 55 years or over. International Journal of Industrial Ergonomics 2024;102:103607 View
45. Hussain M, Waris A, Gilani S, Mushtaq S, Pujari A, Khan N, Jameel M, Daminova G, Khan M. Virtual reality as a non-conventional rehabilitation for stroke: A comprehensive review. Journal of Neurorestoratology 2024;12(3):100135 View
46. Gao L, Pan L, Yang H. Effects of virtual reality‐based cognitive interventions on cognitive function and activity of daily living among stroke patients: Systematic review and meta‐analysis. Journal of Clinical Nursing 2024 View
47. Arman S, Menekseoglu A, Sezgin B, Ozgur B, Capan N, Oral A. The effects of virtual reality-mediated tendon and nerve gliding exercises in the conservative management of carpal tunnel syndrome: a double-blind randomized placebo controlled trial. European Journal of Physical and Rehabilitation Medicine 2024;60(3) View
48. Sakurai M, Spitzley K, Karduna A. Awareness of Visual Offset Reduces but Does Not Eliminate Joint Repositioning Errors in Virtual Reality. Journal of Motor Behavior 2024;56(5):592 View
49. Paul R, Elango S, Chakravarthy S, Sinha A, P R S, Raju B, C K, Sarma P, Hafsath S, Francis A, Darshini D, Sylaja P. Feasibility and efficacy of virtual reality rehabilitation compared with conventional physiotherapy for upper extremity impairment due to ischaemic stroke: protocol for a randomised controlled trial. BMJ Open 2024;14(7):e086556 View
50. Slamon N, Nwankwor O, Canter K, Lewis A, Setlur A, Lutz J. Creation of a Virtual Reality Telesimulation Program in Response to Mandatory COVID-19 Social Distancing During the Pandemic: A Primer for Those considering VR Simulation and Application to a Group of Physicians Naive to Virtual Reality. Journal of Medical Extended Reality 2024;1(1):179 View
51. Haghedooren E, Haghedooren R, Langer D, Gosselink R. Feasibility and safety of interactive virtual reality upper limb rehabilitation in patients with prolonged critical illness. Australian Critical Care 2024;37(6):949 View
52. Migliore S, Casella M, Tramontano C, Curcio G, Squitieri F. Virtual reality tolerability, sense of presence and usability in Huntington disease: a pilot study. Neurological Sciences 2024 View
53. Victor B, R A, Angel I S, Kumar B G. Enhancing Dynamic Balance and Postural Stability in Stroke Patients: The Impact of Immersive Virtual Reality Training. Cureus 2024 View
54. Hernández-Martínez A, Fernandez-Escabias M, Amaya-Pascasio L, Carrilho-Candeias S, Ramos-Teodoro M, Gil-Rodríguez M, Orellana-Jaen A, Martínez-Rosales E, Ruiz-González D, Esteban-Simón A, Castro-Ropero B, del-Olmo-Iruela L, López-López M, Ramos-Herrera A, Fajardo-Rodríguez M, Gómez-García S, Rodríguez-Camacho M, Conde-Negri E, Rodríguez-Pérez M, Marcos-Pardo P, Ruiz J, Villegas-Rodríguez I, Amaro-Gahete F, Martínez-Sánchez P, Soriano-Maldonado A. Evaluation of the effects of a gamified, fully immersive and stroke-specific virtual reality intervention for improving disability and quality of life in patients with stroke in the subacute phase: study protocol of the RESET randomised trial. BMJ Open Sport & Exercise Medicine 2024;10(3):e002123 View
55. Han Y, Yi C. Effect of Home-based Rehabilitation on Balance and Gait Function in Patient With Stroke: A Systematic Review and Meta-analysis. Physical Therapy Korea 2024;31(2):91 View
56. Inagaki S, Matsuura H, Sakurai K, Minati L, Yoshimura N. Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task. Brain Sciences 2024;14(8):840 View
57. Li X, Shao Z, Li Z, Wei X, Zong L, Wang P, Zhou T, Wang H. The relationship between the functional status of upper extremity motor neurons and motor function and prognosis in stroke patients. Frontiers in Neurology 2024;15 View
58. Pavan A, Fasano A, Lattanzi S, Cortellini L, Cipollini V, Insalaco S, Mauro M, Germanotta M, Aprile I. Effectiveness of Two Models of Telerehabilitation in Improving Recovery from Subacute Upper Limb Disability after Stroke: Robotic vs. Non-Robotic. Brain Sciences 2024;14(9):941 View
59. Hao J, Crum G, Siu K. Effects of virtual reality on stroke rehabilitation: An umbrella review of systematic reviews. Health Science Reports 2024;7(9) View
60. Moreira M, Vilhena E, Carvalho V, Duque D. A Virtual Reality Game-Based Approach for Shoulder Rehabilitation. Multimodal Technologies and Interaction 2024;8(10):86 View
61. Patel S, Baker N. Exploring perspectives on engagement in interactive virtual reality for chronic pain management: insights from a content analysis study. Virtual Reality 2024;28(4) View
62. Khan A, Imam Y, Muneer M, Al Jerdi S, Gill S. Virtual reality in stroke recovery: a meta-review of systematic reviews. Bioelectronic Medicine 2024;10(1) View
63. Tang Q, Yang X, Sun M, He M, Sa R, Zhang K, Zhu B, Li T. Research trends and hotspots of post-stroke upper limb dysfunction: a bibliometric and visualization analysis. Frontiers in Neurology 2024;15 View
64. Ghoneim O, Galal D, Al-Afify D, El Ebrashy M, Zidan F, Saad R. Effectiveness of intensive motor learning approaches from working on a vertical surface on hemiplegic children’s upper limb motor skills, a randomized controlled trial. Disability and Rehabilitation 2024:1 View
65. Usuda K, Uesaka T, Okubo T, Shimada T, Shimada C, Ito H, Douko N, Aoki T, Takada M, Yokoyama K, Shimizu M, Kitagawa K, Itamoto N, Shimada O. How Are FIM Gains Improved after Intensive Rehabilitation for Cerebrovascular Diseases?. Balneo and PRM Research Journal 2024;15(Vol.15, no. 3):721 View
66. Chiu M, Tochilnikova E, Harteveld C. From Novelty to Clinical Practice: Exploring VR Exergames with Physical Therapists. Proceedings of the ACM on Human-Computer Interaction 2024;8(CHI PLAY):1 View
67. Shyamal K. Sports and Exercise Medicine: Present and Future. Archives of Sports Medicine and Physiotherapy 2024;9(1):008 View
68. Wei X, Zhou P, Wei Y, Wu D, Qin P, Zhang Y, Zhu J, Ren Z, Li H, Zhang Y. Comparison of Occupational Performance in Immersive Virtual and Real Environments Among Patients With Stroke: Observational Randomized Crossover Pilot Study. JMIR Serious Games 2024;12:e58388 View
69. Jansen L, de Zande E, de Korne D, Andringa G. Feasibility of implementing immersive and non-interactive virtual reality interventions in elderly populations: A scoping review. Geriatric Nursing 2025;61:217 View
70. Wang S, Zhou Y, Wu Y, Lang Y, Mao Y, Pan G, Gao Z. Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice. Frontiers in Neuroscience 2024;18 View
71. Chenais N, Görgen A. Immersive interfaces for clinical applications: current status and future perspective. Frontiers in Neurorobotics 2024;18 View
72. Junga A, Schulze H, Scherzer S, Hätscher O, Bozdere P, Schmidle P, Risse B, Marschall B. Immersive learning in medical education: analyzing behavioral insights to shape the future of VR-based courses. BMC Medical Education 2024;24(1) View
73. Krohn M, Rintala A, Immonen J, Sjögren T. The Effectiveness of Therapeutic Exercise Interventions With Virtual Reality on Balance and Walking Among Persons With Chronic Stroke: Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Controlled Trials. Journal of Medical Internet Research 2024;26:e59136 View

Books/Policy Documents

1. Urakov A, Samorodov A, Sokolova V. Stroke - Management Pearls. View
2. Darekar A. Virtual Reality in Behavioral Neuroscience: New Insights and Methods. View
3. Hamasaki H. New Horizons of Exercise Medicine. View
4. Mohammed M. Difficulties and Challenges in Geriatric Health Management. View
5. . Virtual Reality Technology. View
6. Wolfram S, Bauer R. Evidenzbasierte medizinische Trainingstherapie. View
7. Kubota M, Konnai T, Takami Y, Matsuo H, Tsubaki A, Nagamune K. Oxygen Transport to Tissue XLV. View