Digital Health Technologies to Improve Medication Adherence and Treatment Outcomes in Patients With Tuberculosis: Systematic Review of Randomized Controlled Trials

Journals

1. Pradipta I, Khairunnisa K, Bahar M, Kausar M, Fitriana E, Ruslami R, Aarnoutse R, Abdulah R. Knowledge, attitude and practice of community pharmacy personnel in tuberculosis patient detection: a multicentre cross-sectional study in a high-burden tuberculosis setting. BMJ Open 2022;12(7):e060078 View
2. Shoaib M, Kainat S, Raja M, Nisar K. Design of artificial neural networks optimized through genetic algorithms and sequential quadratic programming for tuberculosis model. Waves in Random and Complex Media 2025;35(5):8243 View
3. Iskandar D, Suwantika A, Pradipta I, Postma M, van Boven J. Clinical and economic burden of drug-susceptible tuberculosis in Indonesia: national trends 2017–19. The Lancet Global Health 2023;11(1):e117 View
4. Pradipta I, Idrus L, Probandari A, Puspitasari I, Santoso P, Alffenaar J, Hak E. Barriers to Optimal Tuberculosis Treatment Services at Community Health Centers: A Qualitative Study From a High Prevalent Tuberculosis Country. Frontiers in Pharmacology 2022;13 View
5. Bundogji N, Toma G, Khan A. Identification of preferred reminder systems and patient factors to promote adherence in the management of urinary incontinence. PEC Innovation 2022;1:100067 View
6. Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Linnemayr S, Haberer J. Digital Adherence Technologies and Mobile Money Incentives for Management of Tuberculosis Medication Among People Living With Tuberculosis: Mixed Methods Formative Study. JMIR Formative Research 2023;7:e45301 View
7. Kardas P, Ágh T, Dima A, Goetzinger C, Potočnjak I, Wettermark B, van Boven J. Half a Century of Fragmented Research on Deviations from Advised Therapies: Is This a Good Time to Call for Multidisciplinary Medication Adherence Research Centres of Excellence?. Pharmaceutics 2023;15(3):933 View
8. Mangan J, Woodruff R, Winston C, Nabity S, Haddad M, Dixon M, Parvez F, Sera-Josef C, Salmon-Trejo L, Lam C. Recommendations for Use of Video Directly Observed Therapy During Tuberculosis Treatment — United States, 2023. MMWR. Morbidity and Mortality Weekly Report 2023;72(12):313 View
9. Liu X, Thompson J, Dong H, Sweeney S, Li X, Yuan Y, Wang X, He W, Thomas B, Xu C, Hu D, Vassall A, Huan S, Zhang H, Jiang S, Fielding K, Zhao Y. Digital adherence technologies to improve tuberculosis treatment outcomes in China: a cluster-randomised superiority trial. The Lancet Global Health 2023;11(5):e693 View
10. Pradipta I, Yanuar E, Nurhijriah C, Maharani N, Subra L, Destiani D, Diantini A. Practical Models of Pharmaceutical Care for Improving Tuberculosis Patient Detection and Treatment Outcomes: A Systematic Scoping Review. Tropical Medicine and Infectious Disease 2023;8(5):287 View
11. Alfian S, Khoiry Q, Andhika A. Pratama M, Pradipta I, Kristina S, Zairina E, Hak E, Abdulah R. Knowledge, perception, and willingness to provide telepharmacy services among pharmacy students: a multicenter cross-sectional study in Indonesia. BMC Medical Education 2023;23(1) View
12. Iskandar D, Pradipta I, Anggriani A, Postma M, van Boven J. Multidisciplinary tuberculosis care: leveraging the role of hospital pharmacists. BMJ Open Respiratory Research 2023;10(1):e001887 View
13. Wu Z, Lu L, Li Y, Chen J, Zhang Z, Ning C, Yuan Z, Pan Q, Shen X, Zhang W. Effect of mobile health reminders on tuberculosis treatment outcomes in Shanghai, China: A prospective cohort study. Frontiers in Public Health 2023;11 View
14. Ramos J, Vieira M, Pimentel C, Argel M, Barbosa P, Duarte R. Building bridges: multidisciplinary teams in tuberculosis prevention and care. Breathe 2023;19(3):230092 View
15. Jerene D, Levy J, van Kalmthout K, Rest J, McQuaid C, Quaife M, Charalambous S, Gamazina K, Garfin A, Mleoh L, Terleieva Y, Bogdanov A, Maraba N, Fielding K. Effectiveness of digital adherence technologies in improving tuberculosis treatment outcomes in four countries: a pragmatic cluster randomised trial protocol. BMJ Open 2023;13(3):e068685 View
16. Janssen S, Upton C, De Jager V, Faraj A, Pahar M, Miranda I, Diacon A, Simonsson U, Niesler T. Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study. Annals of the American Thoracic Society 2023;20(12):1822 View
17. Lee S, Rajaguru V, Baek J, Shin J, Park Y. Digital Health Interventions to Enhance Tuberculosis Treatment Adherence: Scoping Review. JMIR mHealth and uHealth 2023;11:e49741 View
18. Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Musinguzi N, Muzoora C, Bangsberg D, Davis J, Haberer J, Coffee M. The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial. PLOS Global Public Health 2023;3(12):e0001813 View
19. Maingi S, O’Malley E. Impact of text reminders on pneumatic compression device (PCD) compliance in patients with breast cancer-related lymphedema. Supportive Care in Cancer 2024;32(1) View
20. Syarifah S, Santi D. The trial of sending short message service multidrug-resistant tuberculosis patients in Indonesia. Journal of Public Health in Africa 2023 View
21. Cao W, Wang J, Wang Y, Hassan I, Kadir A. mHealth App to improve medication adherence among older adult stroke survivors: Development and usability study. DIGITAL HEALTH 2024;10 View
22. Killian J, Jain M, Jia Y, Amar J, Huang E, Tambe M. New Approach to Equitable Intervention Planning to Improve Engagement and Outcomes in a Digital Health Program: Simulation Study. JMIR Diabetes 2024;9:e52688 View
23. Haldane V, Zhang Z, Yin T, Zhang B, Li Y, Pan Q, Dainty K, Rea E, Pasang P, Hu J, Wei X. Exploring opportunities to strengthen rural tuberculosis health service delivery: a qualitative study with health workers in Tibet autonomous region, China. BMJ Open 2024;14(5):e079062 View
24. Alfian S, Sania J, Aini D, Khoiry Q, Griselda M, Ausi Y, Zakiyah N, Puspitasari I, Suwantika A, Mahfud M, Aji S, Abdulah R, Kassianos A. Evaluation of usability and user feedback to guide telepharmacy application development in Indonesia: a mixed-methods study. BMC Medical Informatics and Decision Making 2024;24(1) View
25. Xianyu F, Huang Y, Guo S, Chongsuvivatwong V. Evaluating Treatment Outcomes and Tuberculosis Infection Risks: A Comparative Study of Centralized Hospitalization vs. Home-Based Treatment. Tropical Medicine and Infectious Disease 2024;9(5):119 View
26. Zary M, Mohamed M, Kafie C, Chilala C, Bahukudumbi S, Foster N, Gore G, Fielding K, Subbaraman R, Schwartzman K. The performance of digital technologies for measuring tuberculosis medication adherence: a systematic review. BMJ Global Health 2024;9(7):e015633 View
27. Kamusheva M, Aarnio E, Qvarnström M, Hafez G, Mucherino S, Potočnjak I, Trečiokiene I, Mihajlović J, Ekenberg M, van Boven J, Leiva‐Fernandez F. Pan‐European survey on medication adherence management by healthcare professionals. British Journal of Clinical Pharmacology 2024;90(12):3135 View
28. Sodhi R, Vatsyayan V, Panibatla V, Sayyad K, Williams J, Pattery T, Pal A, Ayatollahi H. Impact of a pilot mHealth intervention on treatment outcomes of TB patients seeking care in the private sector using Propensity Scores Matching—Evidence collated from New Delhi, India. PLOS Digital Health 2024;3(9):e0000421 View
29. Liquori G, Panattoni N, De Leo A, Dionisi S, Giannetta N, Gasperi B, Orsi G, Di Muzio F, Di Muzio M, Di Simone E. A Phenomenological Approach to Medication Adherence in Elderly Patients: A Qualitative Study. Healthcare 2024;12(19):1925 View
30. Areas Lisboa Netto T, Diniz B, Odutola P, Dantas C, de Freitas M, Hefford P, Bes T, Pappas G. Video-observed therapy (VOT) vs directly observed therapy (DOT) for tuberculosis treatment: A systematic review on adherence, cost of treatment observation, time spent observing treatment and patient satisfaction. PLOS Neglected Tropical Diseases 2024;18(10):e0012565 View
31. Goscé L, Tadesse A, Foster N, van Kalmthout K, Rest J, van der Wal J, Harker M, Madden N, Abdurhman T, Gadissa D, Bedru A, Dube T, Alacapa J, Mganga A, Deyanova N, Charalambous S, Letta T, Jerene D, White R, Fielding K, Houben R, McQuaid C. Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia. BMJ Global Health 2024;9(12):e016997 View
32. Li M, Liu S, Yu B, Li N, Lyu A, Yang H, He H, Zhang N, Ma J, Sun M, Du H, Gao R. Assessing the Effectiveness of Digital Health Behavior Strategies on Type 2 Diabetes Management: Systematic Review and Network Meta-Analysis. Journal of Medical Internet Research 2025;27:e63209 View
33. Pradipta I, Aprilio K, Ningsih Y, Pratama M, Gatera V, Alfian S, Iskandarsyah A, Abdulah R. How Does Indonesian Chronic Disease Patient Adhere to Their Treatment? A Cross-Sectional Analysis of 11,408 Subjects. Patient Preference and Adherence 2025;Volume 19:173 View
34. Győrffy Z, Döbrössy B, Boros J, Girasek E. Unveiling the digital future: perspectives of Hungarian physicians under 35 years old on eHealth solutions. Frontiers in Digital Health 2025;6 View
35. Rissaadah S, Nursiswati N, Pahria T. Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review. Journal of Multidisciplinary Healthcare 2025;Volume 18:747 View
36. Chilala C, Foster N, Bahukudumbi S, Mohamed M, Zary M, Kafie C, Patel B, Gore G, Schwartzman K, Subbaraman R, Fielding K. Implementation outcomes of tuberculosis digital adherence technologies: a scoping review using the RE-AIM framework. BMJ Global Health 2025;10(2):e016535 View
37. Santosa A, Juniarti N, Pahria T, Susanti R. Integrating narrative and bibliometric approaches to examine factors and impacts of tuberculosis treatment non-compliance. Multidisciplinary Respiratory Medicine 2025;20(Vol. 20 (2025)) View
38. Sales J, da Silva K, Martins A, Lopes M, Tavares C, Cavalcante E. Educational Technologies to Promote Self-Care in People Affected by Leprosy: A Systematic Review. Aquichan 2025;25(1):1 View
39. Octavia D, Hermansyah A, Nita Y, Zairina E. Enhancing tuberculosis patient safety: The impact of interprofessional collaboration based telecare on drug-related problems in a randomized control trial. Indian Journal of Tuberculosis 2025 View
40. Balakrishnan V, Kumaresan T, Surendra H, Allsop M, Tiong C, Jian Sheng N, Mohtar M, Tan C. Developing and assessing MyTBCompanion – A tri-lingual integrated video observed therapy app for tuberculosis patient management in Malaysia and Indonesia. PLOS One 2025;20(4):e0320394 View
41. Pradipta I, Florencia C, Mardhiyyah C, Nurfadila F, Aprilio K, Abdulah R, Lestari B, Ruslami R, Lestari T, Aarnoutse R. Engaging community pharmacy in tuberculosis case detection (ENHANCE): a study protocol for an implementation study in Indonesia. Archives of Public Health 2025;83(1) View
42. Patel S, Narkhede K, Prajapati A, Narkhede S, Luhar S. Impact of Digital Health Technologies on Medication Adherence. Asian Journal of Research in Pharmaceutical Sciences 2025:141 View
43. del-Cura M, Jimeno Anaya L, Sastre Ibáñez M, Quijada-Angeli S, Martín-Herrero A, Pastora-Salvador N, Sánchez Marugán B, Martínez Sánchez M, Castaño Martín B, Crespo-Carballés M. Adherence and Awareness of Patients with Age-Related Macular Degeneration to AREDS 2 Recommended Nutritional Supplements. Journal of Nutrition in Gerontology and Geriatrics 2025;44(2):123 View
44. Memon S, Bibi S, He G. Integration of AI and ML in Tuberculosis (TB) Management: From Diagnosis to Drug Discovery. Diseases 2025;13(6):184 View
45. Schnorrerova P, Matalova P, Wawruch M. Medication Adherence and Intervention Strategies: Why Should We Care. Bratislava Medical Journal 2025;126(7):1196 View
46. Alotaibi A, AlQahtani A, Alateeq M, Saleem M, Khan M. Digital health tools in the management of allergic rhinitis: a systematic review. European Archives of Oto-Rhino-Laryngology 2025;282(12):6029 View
47. Miladi Q, Pahria T, Pramukti I. Effectiveness of Digital Health Interventions to Enhance Continuity of Care in Patients with Pulmonary Tuberculosis: A Systematic Review of Randomized Controlled Trials. Patient Preference and Adherence 2025;Volume 19:1807 View
48. Yuliasih N, Khoiry Q, Alfian S, Suwantika A, Abdulah R. Facilitator and Barrier to Health Information System Use from Health Professionals Perspective: A Scoping Review. Journal of Multidisciplinary Healthcare 2025;Volume 18:3901 View
49. Yusransyah Y, Stiani S, Chairani F, Adini S, Subchan M, Ferdiyansyah F, Putri N, Pratiwi R, Udin B. Effectiveness of TB-Reminder Application in Improving Medication Adherence and Quality of Life of Lung Tuberculosis Patients in Indonesia. Sciences of Pharmacy 2025;4(3):117 View
50. Maulana S, Lutfian L, Wardika I, Fadhli R, Anggreani D, Haposan J, Wildana F, Efendi M, Platini H, Haroen H. Emerging Research Trends on Medication Adherence in Tuberculosis Treatment: A Bibliometric Study of Research Between 2015 and 2024 to Inform Future Research Trajectory. Patient Preference and Adherence 2025;Volume 19:2213 View
51. Zhang J, Yu W, Wu X, Zhang S, Yang M, Luo M, Jiang J, Mai M, Ho L, Chan D. Multicomponent self-management intervention for cancer patients with pain: A pilot randomized controlled study. European Journal of Oncology Nursing 2025;78:102964 View
52. Parthasarathy R, Elangovan L, Magesh M, Rajagopal J. Exploring the Role of Digital Adherence Technology in Enhancing Patient Care for Tuberculosis in India: A Systematic Review of Qualitative Research. Journal of Clinical Infectious Disease Society 2025;3(3):86 View
53. Roberti J, Morelli D, Aguilar-Vidrio O, Suyanto A, Carmiol-Rodriguez P, Tolentino A, Chen-Liang E, Sprecher J, Rubinstein F, Iribarren S. Improving tuberculosis treatment adherence: a qualitative study of patients’ perspectives from a pragmatic trial of the tuberculosis treatment support tools intervention. BMJ Open 2025;15(9):e095878 View
54. Cheng Q, Chen P, Dai R, Jia Q, Bai X, Cao Q, Li Q, Wu Y, Huang Y. Comparative Effectiveness of Digital Health Technologies in Tuberculosis Treatment: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. JMIR mHealth and uHealth 2025;13:e75424 View
55. Frighetto I, Ely K, Koepp J, Boeira E, da Silva Corcini L, do Prado T, de Moura Valim A, Possuelo L. Evaluation of a mobile application (PPLife) for training prison staff on infectious disease management: a design science research approach. BMC Digital Health 2025;3(1) View
56. Mohamed M, Zary M, Kafie C, Chilala C, Bahukudumbi S, Foster N, Gore G, Fielding K, Subbaraman R, Schwartzman K. The impact of digital adherence technologies on treatment outcomes, adherence, and patient-reported outcomes in tuberculosis: a systematic review and meta-analysis. BMC Infectious Diseases 2025;25(1) View
57. Xie F, Yao R, Liang L, Wu C, Hu Y, Zhou Y, Huang M, Du J, Zhao X, Wan B, Xia S. Evidence‐Based Summary on Medication Adherence Management for Adult Tuberculosis Patients With Multi‐Dimensional Strategies and Practice Framework. Journal of Evaluation in Clinical Practice 2025;31(7) View
58. Orolfo D, Pinar F, Reyes A. Effectiveness of telemedicine interventions for the management of tuberculosis in low- and middle-income countries (LMICs): a systematic review protocol. JBI Evidence Synthesis 2025 View
59. Santosa A, Juniarti N, Pahria T, Susanti R. Digital adherence technology to improve medication adherence in tuberculosis patients: a systematic review and meta-analysis randomized control trials. npj Primary Care Respiratory Medicine 2025;35(1) View
60. Zhao F, Zhong H, Kang P, Sun S, Zhang T, Cui S, Bi S. Review of clinical medication adherence in patients with schizophrenia. World Journal of Psychiatry 2025;15(12) View
61. Robbiati C, Tosti M, Tomas J, Natali G, Simeis L, Silva N, Joaquim F, Tulomba D, Lazary N, Adão J, Manenti F, Dente M. Digital health for Tuberculosis control: findings from the piloting of an electronic medical record in Luanda (Angola). BMC Medical Informatics and Decision Making 2025 View
62. Wilandika A, Rahmawati E, Yusof S, Handayani P. A visual reminder chart to improve tuberculosis treatment adherence and self-management in a low-resource setting. Journal of Public Health 2025 View

Books/Policy Documents

1. Fielding K, Subbaraman R, Khan A, Celan C, Charalambous S, Franke M, Huddart S, Katamba A, Law S, Stagg H. Digital Respiratory Healthcare. View
2. Dima A, Nabergoj‐Makovec U, van Boven J. Drug Utilization Research. View
3. Merino-Barbancho B, Rujas M, Gómez del Moral Herranz R, Livitckaia K, Pantelidou K, Castellano E, Kostopoulou K, Cabrera M, Arredondo M, Fico G. Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management. View