Published on in Vol 22, No 11 (2020): November

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/22179, first published .
Online Patient Recruitment in Clinical Trials: Systematic Review and Meta-Analysis

Online Patient Recruitment in Clinical Trials: Systematic Review and Meta-Analysis

Online Patient Recruitment in Clinical Trials: Systematic Review and Meta-Analysis

Journals

  1. Fowler J, Skubiak T, Engelhardt K, Furst B, Zhao S, Nyilas M, Profit D, Carson W. Feasibility of a Noninterventional Decentralized Clinical Trial Model in Adults with Major Depressive Disorder. Journal of Scientific Innovation in Medicine 2021;4(1):1 View
  2. Mirza M, Siebert S, Pratt A, Insch E, McIntosh F, Paton J, Wright C, Buckley C, Isaacs J, McInnes I, Raza K, Falahee M. Impact of the COVID‐19 pandemic on recruitment to clinical research studies in rheumatology. Musculoskeletal Care 2022;20(1):209 View
  3. Cook S, Jerome R, Dunagan J, Kennedy N, Edwards T, Minnix J, Witmer L, Ferguson J, Cinciripini P, Wilkins C, Harris P. Engaging smokers in research: Utility of Facebook in facilitating recruitment to a smoking cessation study. Contemporary Clinical Trials 2021;107:106461 View
  4. Hoeflich C, Wang A, Otufowora A, Cottler L, Striley C. Virtual recruitment and participant engagement for substance use research during a pandemic. Current Opinion in Psychiatry 2022;35(4):252 View
  5. Chatters R, Cooper C, O’Cathain A, Murphy C, Lane A, Sutherland K, Burton C, Cape A, Tunnicliffe L. Learning from COVID-19 related trial adaptations to inform efficient trial design—a sequential mixed methods study. BMC Medical Research Methodology 2022;22(1) View
  6. Pugmire J, Lever Taylor J, Wilkes M, Wolfberg A, Zahradka N. Participant Experiences of a COVID-19 Virtual Clinical Study Using the Current Health Remote Monitoring Platform: Case Study and Qualitative Analysis. JMIR Formative Research 2022;6(7):e37567 View
  7. de Jong A, van Rijssel T, Zuidgeest M, van Thiel G, Askin S, Fons‐Martínez J, De Smedt T, de Boer A, Santa‐Ana‐Tellez Y, Gardarsdottir H. Opportunities and Challenges for Decentralized Clinical Trials: European Regulators’ Perspective. Clinical Pharmacology & Therapeutics 2022;112(2):344 View
  8. O'Sullivan Greene E, Shiely F. Recording and reporting of recruitment strategies in trial protocols, registries, and publications was nonexistent. Journal of Clinical Epidemiology 2022;152:248 View
  9. Hoffmann S, Paldam Folker A, Buskbjerg M, Paldam Folker M, Huber Jezek A, Lyngsø Svarta D, Nielsen Sølvhøj I, Thygesen L. Potential of Online Recruitment Among 15-25-Year Olds: Feasibility Randomized Controlled Trial. JMIR Formative Research 2022;6(5):e35874 View
  10. Gouveia R, Cruz V, Almeida L. Sociodemographic and psychological characteristics influencing patients’ willingness to participate in clinical trials. BMJ Open Quality 2022;11(4):e002044 View
  11. Pertl K, Petluri R, Wiest K, Hoffman K, McCarty D, Levander X, Chan B, Martin S, Korthuis P. Recruitment challenges for a prospective telehealth cohort study. Contemporary Clinical Trials Communications 2023;31:101043 View
  12. Ben-Zeev D, Chander A, Tauscher J, Buck B, Nepal S, Campbell A, Doron G. A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORE. Journal of Medical Internet Research 2021;23(11):e29201 View
  13. Ali Z, Valk T, Bjerre-Christensen T, Brandt S, Isberg A, Jensen M, Helledi L, Kaas A, Thomsen S, Andersen A, Robert Zibert J. Exploring Decentralized Glucose and Behaviometric Monitoring of Persons with Type 2 Diabetes in the Setting of a Clinical Trial. Journal of Diabetes Science and Technology 2023;17(1):117 View
  14. Sciamanna C, Ballentine N, Bopp M, Chinchilli V, Ciccolo J, Delauter G, Fisher A, Fox E, Jan De Beur S, Kearcher K, Kraschnewski J, Lehman E, McTigue K, McAuley E, Paranjape A, Rodriguez-Colon S, Rovniak L, Rutt K, Smyth J, Stewart K, Stuckey H, Tsay A. Working to Increase Stability through Exercise (WISE): screening, recruitment, and baseline characteristics. Trials 2021;22(1) View
  15. Ellington M, Connelly J, Clayton P, Lorenzo C, Collazo-Velazquez C, Trak-Fellermeier M, Palacios C. Use of Facebook, Instagram, and Twitter for recruiting healthy participants in nutrition-, physical activity–, or obesity-related studies: a systematic review. The American Journal of Clinical Nutrition 2022;115(2):514 View
  16. Roberts J, Chervinskiy S, McCulloh R, Snowden J, Darden P, Phan T, Dawley E, Reynolds V, Lim C, Pyles L, Hubberd D, Baldner J, Lawrence L, Davis A. Conducting a pediatric randomized clinical trial during a pandemic: A shift to virtual procedures. Journal of Clinical and Translational Science 2022;6(1) View
  17. Jacob S, Anagnostou E, Hollander E, Jou R, McNamara N, Sikich L, Tobe R, Murphy D, McCracken J, Ashford E, Chatham C, Clinch S, Smith J, Sanders K, Murtagh L, Noeldeke J, Veenstra-VanderWeele J. Large multicenter randomized trials in autism: key insights gained from the balovaptan clinical development program. Molecular Autism 2022;13(1) View
  18. Zimmermann B, Willem T, Bredthauer C, Buyx A. Ethical Issues in Social Media Recruitment for Clinical Studies: Ethical Analysis and Framework. Journal of Medical Internet Research 2022;24(5):e31231 View
  19. Vogel M, Krüger J, Junne F. Eating disorder related research using Amazon Mechanical Turk (MTurk): Friend or foe?: Commentary on Burnette et al. (2021). International Journal of Eating Disorders 2022;55(2):285 View
  20. Miller H, Plante T, Gleason K, Charleston J, Mitchell C, Miller E, Appel L, Juraschek S. A/B design testing of a clinical trial recruitment website: A pilot study to enhance the enrollment of older adults. Contemporary Clinical Trials 2021;111:106598 View
  21. Hausmann J, Vizcaino‐Riveros J, Marin A, Minegishi M, Cox R, Chang M, Schanberg L, Natter M, Weitzman E. Feasibility and Efficacy of Online Strategies to Recruit Parents of Children With Rheumatic Diseases for Research. ACR Open Rheumatology 2022;4(5):410 View
  22. Mueller C, Schauerte I, Martin S, Irrgang V. Evaluation of Self-care Activities and Quality of Life in Patients With Type 2 Diabetes Treated With Metformin Using the 2D Matrix Code of Outer Drug Packages as Patient Identifier: the DePRO Proof-of-Concept Observational Study. JMIR Diabetes 2022;7(2):e31832 View
  23. Pogue J, Graca B, Adams M, Kruegar C, Patel R, Bennett M, Powers M, Warren A. Strategies and lessons learned from a longitudinal study to maximize recruitment in the midst of a global pandemic. Baylor University Medical Center Proceedings 2022;35(3):309 View
  24. Stoffel S, Law J, Kerrison R, Brewer H, Flanagan J, Hirst Y. Testing the Effectiveness of an Animated Decision Aid to Improve Recruitment of Control Participants in a Case-Control Study: Web-Based Experiment. Journal of Medical Internet Research 2022;24(8):e40015 View
  25. Cochrane K, Hutcheon J, Karakochuk C. Strategies for improving recruitment of pregnant women to clinical research: An evaluation of social media versus traditional offline methods. DIGITAL HEALTH 2022;8:205520762210957 View
  26. Zahradka N, Pugmire J, Lever Taylor J, Wolfberg A, Wilkes M. Deployment of an End-to-End Remote, Digitalized Clinical Study Protocol in COVID-19: Process Evaluation. JMIR Formative Research 2022;6(7):e37832 View
  27. de Jong A, Grupstra R, Santa-Ana-Tellez Y, Zuidgeest M, de Boer A, Gardarsdottir H. Which decentralised trial activities are reported in clinical trial protocols of drug trials initiated in 2019–2020? A cross-sectional study in ClinicalTrials.gov. BMJ Open 2022;12(8):e063236 View
  28. Peyser N, Marcus G, Beatty A, Olgin J, Pletcher M. Digital platforms for clinical trials: The Eureka experience. Contemporary Clinical Trials 2022;115:106710 View
  29. Brøgger-Mikkelsen M, Zibert J, Andersen A, Lassen U, Hædersdal M, Ali Z, Thomsen S, V. E. S. Changes in key recruitment performance metrics from 2008–2019 in industry-sponsored phase III clinical trials registered at ClinicalTrials.gov. PLOS ONE 2022;17(7):e0271819 View
  30. Masoli J, Down K, Nestor G, Hudson S, O’Brien J, Williamson J, Young C, Carroll C. A report from the NIHR UK working group on remote trial delivery for the COVID-19 pandemic and beyond. Trials 2021;22(1) View
  31. Toly V, Eliades A, Miller A, Sidora S, Kracker J, Fiala M, AlShammari T. Collaborative development of an innovative virtual research recruitment strategy through an academic/clinical partnership. Applied Nursing Research 2022;68:151626 View
  32. Cox S, Czuber-Dochan W, Wall C, Clarke H, Drysdale C, Lomer M, Lindsay J, Whelan K. Improving Food-Related Quality of Life in Inflammatory Bowel Disease through a Novel Web Resource: A Feasibility Randomised Controlled Trial. Nutrients 2022;14(20):4292 View
  33. Mackereth P, Stringer J. Receiving acupuncture for chemotherapy-induced peripheral neuropathy: A nested qualitative study. European Journal of Integrative Medicine 2023;60:102258 View
  34. Huang X, Qin X, Li M, Li Y, Shen L, Jin G, Wang Y, Liu J, Li X. Impact of caregivers' psychological and caregiving status on recruitment, conversion, and retention in stem cell therapy trials for cerebral palsy: A prospective survey analysis. Nursing Open 2023;10(8):5293 View
  35. Boisvert-Huneault C, Trigos Herraez D, Pinter A, Kobayashi S, Bell S, Kallsen K, Gloede T, Yagi N, Brunette S, Datsenko Y, Baehner F, Clerisme-Beaty E, Van de Kerkhof P. Understanding potential participation barriers to improve trial design and outcomes: clinical trial simulation in palmoplantar pustulosis as a case study. BMJ Open 2023;13(4):e064159 View
  36. Ko D, Dierker J, Stouff R, Senier L. Telehealth Experience Among Liver and Kidney Transplant Recipients: A Mixed Methods Study. Transplant International 2023;36 View
  37. Shiely F, Murphy D, Millar S. Clinical research nurse predictions of trial failure, recruitment and retention: a case for their early inclusion in trial design. Trials 2023;24(1) View
  38. Bordukova M, Makarov N, Rodriguez-Esteban R, Schmich F, Menden M. Generative artificial intelligence empowers digital twins in drug discovery and clinical trials. Expert Opinion on Drug Discovery 2024;19(1):33 View
  39. Iflaifel M, Hall C, Green H, Willis A, Rennick-Egglestone S, Juszczak E, Townsend M, Martin J, Sprange K. Widening participation – recruitment methods in mental health randomised controlled trials: a qualitative study. BMC Medical Research Methodology 2023;23(1) View
  40. Lorenc A, Rooshenas L, Conefrey C, Wade J, Farrar N, Mills N, Paramasivan S, Realpe A, Jepson M. Non-COVID-19 UK clinical trials and the COVID-19 pandemic: impact, challenges and possible solutions. Trials 2023;24(1) View
  41. Duus Holm Z, Zibert J, Thomsen S, Isberg A, Andersen A, Ali Z. Rapid Web-Based Recruitment of Patients With Psoriasis: Multinational Cohort Study. JMIR Dermatology 2023;6:e44405 View
  42. Ammerman B, Jacobucci R. The impact of social connection on near-term suicidal ideation. Psychiatry Research 2023;326:115338 View
  43. Lepage S, Conway A, Goodson N, Wicks P, Flight L, Devane D, Wong C. Online randomised trials with children: A scoping review. PLOS ONE 2023;18(5):e0280965 View
  44. Lukaschek K, Lezius S, van den Akker M, Hanf M, Zapf A, Heider D, König H, Gensichen J. CBT-Based and eHealth-Supported Case Management for Patients with Panic Disorder or Depression in Primary Care: Results of a Proof of Concept. International Journal of Cognitive Therapy 2023 View
  45. Ortner V, Zibert J, Budnik O, Manole I, Laugesen C, Havsager S, Haedersdal M. Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis. Contemporary Clinical Trials Communications 2024;37:101245 View
  46. Young H, Castle E, Briggs J, Walklin C, Billany R, Asgari E, Bhandari S, Bishop N, Bramham K, Burton J, Campbell J, Chilcot J, Cooper N, Deelchand V, Graham-Brown M, Haggis L, Hamilton A, Jesky M, Kalra P, Koufaki P, Macdonald J, McCafferty K, Nixon A, Noble H, Saynor Z, Taal M, Tollitt J, Wheeler D, Wilkinson T, Greenwood S. The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease. Scientific Reports 2024;14(1) View
  47. Keret S, Lomanto Silva R, Chandra T, Sharma A, Moghadam-Kia S, Oddis C, Aggarwal R. Patient-reported outcome for physical function in idiopathic inflammatory myopathy. Rheumatology 2024 View
  48. Kasson E, Szlyk H, Li X, Constantino‐Pettit A, Smith A, Vázquez M, Wilfley D, Taylor C, Fitzsimmons‐Craft E, Cavazos‐Rehg P. Eating disorder symptoms and comorbid mental health risk among teens recruited to a digital intervention research study via two online approaches. International Journal of Eating Disorders 2024 View
  49. Lee K, Lui Z, Mai Y, Higashi M, Jun T, Ma M, Wang T, Ai L, Calay E, Oh W, Stolovitzky G, Schadt E, Wang X. Empowering Clinical Trials with Natural Language Processing Models and Real-World Data: A Feasibility Study to Optimize Clinical Trial Eligibility Design with Data-driven Simulations (Preprint). JMIR AI 2023 View
  50. Kasahara A, Mitchell J, Yang J, Cuomo R, McMann T, Mackey T. Digital technologies used in clinical trial recruitment and enrollment including application to trial diversity and inclusion: A systematic review. DIGITAL HEALTH 2024;10 View
  51. Slater K, Fivenson D. Incorporating Dermatologic Clinical Research Into Private Practice: A Review. Cureus 2024 View
  52. Daniels A, Law J, Green Snyder L, Diehl K, Goin-Kochel R, Feliciano P, Chung W. Effectiveness of multimodal participant recruitment in SPARK, a large, online longitudinal research study of autism. Journal of Clinical and Translational Science 2024;8(1) View

Books/Policy Documents

  1. Matullo K, Amato C, Burskii P. Blockchain in Healthcare. View