Published on in Vol 21, No 2 (2019): February

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/11016, first published .
Detecting Potential Adverse Drug Reactions Using a Deep Neural Network Model

Detecting Potential Adverse Drug Reactions Using a Deep Neural Network Model

Detecting Potential Adverse Drug Reactions Using a Deep Neural Network Model

Journals

  1. Li X, Lin X, Ren H, Guo J. Ontological Organization and Bioinformatic Analysis of Adverse Drug Reactions From Package Inserts: Development and Usability Study. Journal of Medical Internet Research 2020;22(7):e20443 View
  2. Tobore I, Li J, Yuhang L, Al-Handarish Y, Kandwal A, Nie Z, Wang L. Deep Learning Intervention for Health Care Challenges: Some Biomedical Domain Considerations. JMIR mHealth and uHealth 2019;7(8):e11966 View
  3. Timilsina M, Tandan M, d’Aquin M, Yang H. Discovering Links Between Side Effects and Drugs Using a Diffusion Based Method. Scientific Reports 2019;9(1) View
  4. Rohani N, Eslahchi C. Drug-Drug Interaction Predicting by Neural Network Using Integrated Similarity. Scientific Reports 2019;9(1) View
  5. Pérez-Parras Toledano J, García-Pedrajas N, Cerruela-García G. Multilabel and Missing Label Methods for Binary Quantitative Structure–Activity Relationship Models: An Application for the Prediction of Adverse Drug Reactions. Journal of Chemical Information and Modeling 2019;59(10):4120 View
  6. Spiro A, Fernández García J, Yanover C. Inferring new relations between medical entities using literature curated term co-occurrences. JAMIA Open 2019;2(3):378 View
  7. Adly A, Adly A, Adly M. Approaches Based on Artificial Intelligence and the Internet of Intelligent Things to Prevent the Spread of COVID-19: Scoping Review. Journal of Medical Internet Research 2020;22(8):e19104 View
  8. Nguyen D, Nguyen C, Mamitsuka H. A survey on adverse drug reaction studies: data, tasks and machine learning methods. Briefings in Bioinformatics 2021;22(1):164 View
  9. Bate A, Hobbiger S. Artificial Intelligence, Real-World Automation and the Safety of Medicines. Drug Safety 2021;44(2):125 View
  10. Piroozmand F, Mohammadipanah F, Sajedi H. Spectrum of deep learning algorithms in drug discovery. Chemical Biology & Drug Design 2020;96(3):886 View
  11. Yu Z, Wu Z, Li W, Liu G, Tang Y, Jonathan W. MetaADEDB 2.0: a comprehensive database on adverse drug events. Bioinformatics 2021;37(15):2221 View
  12. Shin H, Cha J, Lee C, Song H, Jeong H, Kim J, Lee S. The 2011–2020 Trends of Data-Driven Approaches in Medical Informatics for Active Pharmacovigilance. Applied Sciences 2021;11(5):2249 View
  13. Bose K, Dutta S, Bose K. Remodelling structure-based drug design using machine learning. Emerging Topics in Life Sciences 2021;5(1):13 View
  14. Lee C, Chen Y. Descriptive prediction of drug side‐effects using a hybrid deep learning model. International Journal of Intelligent Systems 2021;36(6):2491 View
  15. Hwang M, Shin J, Seo H, Im J, Cho H, Bilal M. KoRASA: Pipeline Optimization for Open-Source Korean Natural Language Understanding Framework Based on Deep Learning. Mobile Information Systems 2021;2021:1 View
  16. Joshi P, Vedhanayagam M, Ramesh R. An Ensembled SVM Based Approach for Predicting Adverse Drug Reactions. Current Bioinformatics 2021;16(3):422 View
  17. Verman S, Anjankar A. A Narrative Review of Adverse Event Detection, Monitoring, and Prevention in Indian Hospitals. Cureus 2022 View
  18. Hariry R, Barenji R, Paradkar A. Towards Pharma 4.0 in clinical trials: A future-orientated perspective. Drug Discovery Today 2022;27(1):315 View
  19. Ishikawa T, Yakoh T, Urushihara H. An NLP-Inspired Data Augmentation Method for Adverse Event Prediction Using an Imbalanced Healthcare Dataset. IEEE Access 2022;10:81166 View
  20. Alpay B, Gosink M, Aguiar D. Evaluating molecular fingerprint-based models of drug side effects against a statistical control. Drug Discovery Today 2022;27(11):103364 View
  21. Das P, Yogita , Pal V. Integrative analysis of chemical properties and functions of drugs for adverse drug reaction prediction based on multi-label deep neural network. Journal of Integrative Bioinformatics 2022;19(3) View
  22. Askr H, Elgeldawi E, Aboul Ella H, Elshaier Y, Gomaa M, Hassanien A. Deep learning in drug discovery: an integrative review and future challenges. Artificial Intelligence Review 2023;56(7):5975 View
  23. Joshi P, V M, Mukherjee A. A knowledge graph embedding based approach to predict the adverse drug reactions using a deep neural network. Journal of Biomedical Informatics 2022;132:104122 View
  24. Sato H. Development of Clinical Pharmaceutical Services <i>via</i> Artificial Intelligence Adaptation. YAKUGAKU ZASSHI 2022;142(4):337 View
  25. Das P, Mazumder D. An extensive survey on the use of supervised machine learning techniques in the past two decades for prediction of drug side effects. Artificial Intelligence Review 2023;56(9):9809 View
  26. Chopard D, Treder M, Corcoran P, Ahmed N, Johnson C, Busse M, Spasic I. Text Mining of Adverse Events in Clinical Trials: Deep Learning Approach. JMIR Medical Informatics 2021;9(12):e28632 View
  27. Nguyen D, Nguyen C, Petschner P, Mamitsuka H. SPARSE: a sparse hypergraph neural network for learning multiple types of latent combinations to accurately predict drug–drug interactions. Bioinformatics 2022;38(Supplement_1):i333 View
  28. Huang J, Lee W, Lee K. Predicting Adverse Drug Reactions from Social Media Posts: Data Balance, Feature Selection and Deep Learning. Healthcare 2022;10(4):618 View
  29. Rodríguez-Rodríguez I, Rodríguez J, Shirvanizadeh N, Ortiz A, Pardo-Quiles D. Applications of Artificial Intelligence, Machine Learning, Big Data and the Internet of Things to the COVID-19 Pandemic: A Scientometric Review Using Text Mining. International Journal of Environmental Research and Public Health 2021;18(16):8578 View
  30. Falconer N, Barras M, Abdel-Hafiz A, Radburn S, Cottrell N. Evaluation of two European risk models for predicting medication harm in an Australian patient cohort. European Journal of Clinical Pharmacology 2022;78(4):679 View
  31. Malec S, Wei P, Bernstam E, Boyce R, Cohen T. Using computable knowledge mined from the literature to elucidate confounders for EHR-based pharmacovigilance. Journal of Biomedical Informatics 2021;117:103719 View
  32. Yu Z, Wu Z, Li W, Liu G, Tang Y. ADENet: a novel network-based inference method for prediction of drug adverse events. Briefings in Bioinformatics 2022;23(2) View
  33. Hlavaty A, Roustit M, Montani D, Chaumais M, Guignabert C, Humbert M, Cracowski J, Khouri C. Identifying new drugs associated with pulmonary arterial hypertension: A WHO pharmacovigilance database disproportionality analysis. British Journal of Clinical Pharmacology 2022;88(12):5227 View
  34. Dabare R, Wong K, Shiratuddin M, Koutsakis P. A fuzzy data augmentation technique to improve regularisation. International Journal of Intelligent Systems 2022;37(8):4561 View
  35. Soh J, Park S, Lee H. HIDTI: integration of heterogeneous information to predict drug-target interactions. Scientific Reports 2022;12(1) View
  36. Ali Z, Alturise F, Alkhalifah T, Khan Y, Zhou X. IGPred‐HDnet: Prediction of Immunoglobulin Proteins Using Graphical Features and the Hierarchal Deep Learning‐Based Approach. Computational Intelligence and Neuroscience 2023;2023(1) View
  37. Knisely B, Hatim Q, Vaughn-Cooke M. Utilizing Deep Learning for Detecting Adverse Drug Events in Structured and Unstructured Regulatory Drug Data Sets. Pharmaceutical Medicine 2022;36(5):307 View
  38. Das P, Mazumder D. MLCNN‐COV: A multilabel convolutional neural network‐based framework to identify negative COVID medicine responses from the chemical three‐dimensional conformer. ETRI Journal 2024;46(2):290 View
  39. Zhao H, Ni P, Zhao Q, Liang X, Ai D, Erhardt S, Wang J, Li Y, Wang J. Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework. Communications Biology 2023;6(1) View
  40. Das P, Thakran Y, Anal S, Pal V, Yadav A. BRMCF: Binary Relevance and MLSMOTE Based Computational Framework to Predict Drug Functions From Chemical and Biological Properties of Drugs. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2023;20(3):1761 View
  41. Zhang L, Liu Y, Tian J. Patient Preferences and Their Influence on Chronic Hepatitis B-A Review. Patient Preference and Adherence 2023;Volume 17:3119 View
  42. Arshed M, Ibrahim M, Mumtaz S, Tanveer M, Ahmed S. Chem2Side: A Deep Learning Model with Ensemble Augmentation (Conventional + Pix2Pix) for COVID-19 Drug Side-Effects Prediction from Chemical Images. Information 2023;14(12):663 View
  43. Dauner D, Leal E, Adam T, Zhang R, Farley J. Evaluation of four machine learning models for signal detection. Therapeutic Advances in Drug Safety 2023;14 View
  44. Zhao W, Yao W, Jiang X, He T, Shi C, Hu X. An Explainable Framework for Predicting Drug-Side Effect Associations via Meta-Path-Based Feature Learning in Heterogeneous Information Network. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2023;20(6):3635 View
  45. Uner O, Kuru H, Cinbis R, Tastan O, Cicek A. DeepSide: A Deep Learning Approach for Drug Side Effect Prediction. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2023;20(1):330 View
  46. Modi S, Kasmiran K, Mohd Sharef N, Sharum M. Extracting adverse drug events from clinical Notes: A systematic review of approaches used. Journal of Biomedical Informatics 2024;151:104603 View
  47. Nafea A, Ibrahim M, Mukhlif A, AL-Ani M, Omar N. An Ensemble Model for Detection of Adverse Drug Reactions. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 2024;12(1):41 View
  48. Das P, Mazumder D. Inceptionv3‐LSTM‐COV: A multi‐label framework for identifying adverse reactions to COVID medicine from chemical conformers based on Inceptionv3 and long short‐term memory. ETRI Journal 2024;46(6):1030 View
  49. Das P, Mazumder D. Advances in Predicting Drug Functions: A Decade-Long Survey in Drug Discovery Research. IEEE Transactions on Molecular, Biological, and Multi-Scale Communications 2024;10(1):75 View
  50. Nafea A, AL-Mahdawi M, AL-Ani M, Omar N. A Review on Adverse Drug Reaction Detection Techniques. ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 2024;12(1):143 View
  51. Funari A, Fiscon G, Paci P. Network medicine and systems pharmacology approaches to predicting adverse drug effects. British Journal of Pharmacology 2024 View
  52. Farnoush A, Sedighi-Maman Z, Rasoolian B, Heath J, Fallah B. Prediction of adverse drug reactions using demographic and non-clinical drug characteristics in FAERS data. Scientific Reports 2024;14(1) View
  53. Yao W, Wei A, Xiao Z, Zhao W, Shen X, Jiang X, He T. An Improved Framework for Drug-Side Effect Associations Prediction via Counterfactual Inference-Based Data Augmentation. IEEE Transactions on NanoBioscience 2024;23(4):540 View
  54. Zhao H, Zhong J, Liang X, Xie C, Wang S. Application of machine learning in drug side effect prediction: databases, methods, and challenges. Frontiers of Computer Science 2025;19(5) View
  55. Cucos A, Iantovics L. Comparative Study of Random Forest, Gradient Boosted Trees, Feedforward Neural Networks and Convolutional Neural Networks Using Fingerprints and Molecular Descriptors for Adverse Drug Reaction Prediction. Procedia Computer Science 2024;246:1895 View
  56. Gao Y, Zhang X, Sun Z, Chandak P, Bu J, Wang H. Precision Adverse Drug Reactions Prediction with Heterogeneous Graph Neural Network. Advanced Science 2025;12(4) View
  57. Ranjan S, Singh S. Overcoming catastrophic forgetting in molecular property prediction using continual learning of sequential episodes. Expert Systems with Applications 2025;267:125997 View
  58. Das P, Mazumder D. MLCNNF: A Multi-Label Convolutional Neural Network Framework for Predicting Adverse COVID Drug Reactions From the Chemical Structure. IEEE Transactions on Computational Biology and Bioinformatics 2025;22(1):285 View
  59. Karakoltzidis A, Karakitsios S, Sarigiannis D. AI-driven parametrization of Michaelis–Menten maximal velocity: Advancing in silico new approach methodologies (NAMs). NAM Journal 2025;1:100012 View
  60. Wu J, Nie Y, Liu Z, Tao L, Zheng W. A Knowledge Graph Embedding-based Approach to Predict the Adverse Drug Reactions using a Convolutional Neural Network. Journal of Information & Knowledge Management 2025;24(01) View
  61. Das P. IncV3-BLSTM: a multi-label inceptionV3-BLSTM model for predicting potential side effects of COVID-19 drugs. Annals of Mathematics and Artificial Intelligence 2025 View
  62. Chaurasia A, Kumar D, Yogita . PregAN-NET: Addressing Class Imbalance with GANs in Interpretable Computational Framework for Predicting Safety Profile of Drugs Considering Adverse Reactions During Pregnancy. Journal of Biomedical Informatics 2025;166:104832 View

Books/Policy Documents

  1. Dabare R, Wong K, Shiratuddin M, Koutsakis P. Neural Information Processing. View
  2. Nova S, Rahman M, Hosen A. Rhythms in Healthcare. View
  3. Das P, Sangma J, Pal V, Yogita . Practical Applications of Computational Biology & Bioinformatics, 15th International Conference (PACBB 2021). View
  4. Dabare R, Wong K, Shiratuddin M, Koutsakis P. Neural Information Processing. View
  5. Piroozmand F, Mohammadipanah F, Sajedi H. A Handbook of Artificial Intelligence in Drug Delivery. View
  6. Montero-Colio M, Salas-Zárate M, Paredes-Valverde M. Technologies and Innovation. View
  7. Dey A, Shrivastava J, Kumar C. Intelligent Human Centered Computing. View
  8. Das P, Mazumder D. Mathematical Modeling and Intelligent Control for Combating Pandemics. View
  9. Gupta S, Laghuvarapu S, Priyakumar U. Artificial Intelligence in Healthcare. View

Books/Policy Documents

  1. Rodríguez Rodríguez I, Rodríguez J. Tecnologías digitales disruptivas aplicadas a la gestión de la pandemia por COVID-19: Un análisis a través de la producción científica. View

Conference Proceedings

  1. Peng B, Ning X. Proceedings of the 10th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. Deep Learning for High-Order Drug-Drug Interaction Prediction View
  2. Ji X, Hua L, Wang X, Zhang Y, Li J. 2019 IEEE International Conference on Mechatronics and Automation (ICMA). A Comparison of Methods of Data Mining Algorithms Directed Predictive Pharmacosafety Networks for Adverse Drug Event Detection View
  3. Yao W, Zhao W, Jiang X, Shen X, He T. 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). MPGNN-DSA: A Meta-path-based Graph Neural Network for drug-side effect association prediction View
  4. Grissette H, Nfaoui E. 2020 Seventh International Conference on Social Networks Analysis, Management and Security (SNAMS). Drug Reaction Discriminator within Encoder-Decoder Neural Network Model: COVID-19 Pandemic Case Study View
  5. Das P, Hussain Mazumder D. 2021 5th International Conference on Computational Biology and Bioinformatics. Predicting Anatomical Therapeutic Chemical Drug Classes from 17 molecules’ Properties of Drugs by Multi-Label Binary Relevance Approach with MLSMOTE View
  6. Li H, Hu T, Xiong Z, Zheng C, Feng F, He X, Zhou X. Proceedings of the 17th ACM Conference on Recommender Systems. ADRNet: A Generalized Collaborative Filtering Framework Combining Clinical and Non-Clinical Data for Adverse Drug Reaction Prediction View
  7. Luo J, Qian C, Wang X, Glass L, Ma F. Proceedings of the 32nd ACM International Conference on Information and Knowledge Management. pADR: Towards Personalized Adverse Drug Reaction Prediction by Modeling Multi-sourced Data View
  8. Bera A, Das R, Ghosh S, Chakraborty R, Mitra I, Nandy P. 2023 7th International Conference On Computing, Communication, Control And Automation (ICCUBEA). Harnessing Transformers for Detecting Adverse Drug Reaction and Customized Causality Explanation using Generative AI View
  9. Yao W, Zhao W, Xu X, Jiang X, Shen X, He T. 2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Counterfactual Inference-based Data Augmentation for Drug-side effect Associations Prediction View
  10. Shivanadhuni S, Prakash R. 2024 International Conference on Advancements in Smart, Secure and Intelligent Computing (ASSIC). Review of Various AI Based ADR Detection for Medical Diagnostic Applications View
  11. Raghava Rao Y, Kiran A, Chinnasamy P, Motupalli R, Madhuri K, Kumar D. 2024 International Conference on Advancements in Smart, Secure and Intelligent Computing (ASSIC). Analysis of Stock Market Values Using an Optimal Probability with KNN View
  12. Kumar K, Pavan Kumar C, Mahesh B. 2024 International Conference on Computational Intelligence for Green and Sustainable Technologies (ICCIGST). Predicting Adverse Drug Reactions With Machine Learning View
  13. Funari A, Conte F, Paci P. 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Unveiling drug-induced side effects through network-based analysis: an update View