Background: The internet is a primary source of health information for patients, supplementing physician care. Google Trends (GT), a popular tool, allows the exploration of public interest in health-related phenomena. Despite the growing volume of GT studies, none have focused explicitly on oncology, creating a need for a systematic review to bridge this gap.
Objective: We aimed to systematically characterize studies related to oncology using GT to describe its utilities and biases.
Methods: We included all studies that used GT to analyze Google searches related to malignancies. We excluded studies written in languages other than English. The search was performed using the PubMed engine on August 1, 2022. We used the following search input: “Google trends” AND (“oncology” OR “cancer” or “malignancy” OR “tumor” OR “lymphoma” OR “multiple myeloma” OR “leukemia”). We analyzed sources of bias that included using search terms instead of topics, lack of confrontation of GT statistics with real-world data, and absence of sensitivity analysis. We performed descriptive statistics.
Results: A total of 85 articles were included. The first study using GT for oncology research was published in 2013, and since then, the number of publications has increased annually. The studies were categorized as follows: 22% (19/85) were related to prophylaxis, 20% (17/85) pertained to awareness events, 11% (9/85) were celebrity-related, 13% (11/85) were related to COVID-19, and 47% (40/85) fell into other categories. The most frequently analyzed cancers were breast (n=28), prostate (n=26), lung (n=18), and colorectal cancers (n=18). We discovered that of the 85 studies, 17 (20%) acknowledged using GT topics instead of search terms, 79 (93%) disclosed all search input details necessary for replicating their results, and 34 (40%) compared GT statistics with real-world data. The most prevalent methods for analyzing the GT data were correlation analysis (55/85, 65%) and peak analysis (43/85, 51%). The authors of only 11% (9/85) of the studies performed a sensitivity analysis.
Conclusions: The number of studies related to oncology using GT data has increased annually. The studies included in this systematic review demonstrate a variety of concerning topics, search strategies, and statistical methodologies. The most frequently analyzed cancers were breast, prostate, lung, colorectal, skin, and cervical cancers, potentially reflecting their prevalence in the population or public interest. Although most researchers provided reproducible search inputs, only one-fifth used GT topics instead of search terms, and many studies lacked a sensitivity analysis. Scientists using GT for medical research should ensure the quality of studies by providing a transparent search strategy to reproduce results, preferring to use topics over search terms, and performing robust statistical calculations coupled with sensitivity analysis.
Globally, malignancies remain a significant contributor to morbidity and mortality . Contemporary care of neoplastic conditions is a complex process, demanding precise molecular and radiological diagnostics, advanced treatment strategies, as well as psychological and social support [ ]. Furthermore, we are progressively transitioning toward personalized medicine, in which increasingly more aspects of malignancy treatment are tailored to the patient [ - ]. This intricacy of care, coupled with the use of specialized vocabulary, can make patients with neoplastic conditions and their families feel overwhelmed [ , ], thus prompting them to seek additional information about their disease from readily accessible sources.
The internet has become a significant source of health-related information [- ]. Research indicates that approximately 80% of individuals with cancer seek medical or health-related information on the web [ ]. Many patients perceive this information available on the web as a beneficial complement to the care provided by their physicians [ ]. In addition, access to the internet enables the process of locating specialized medical centers and physicians who can provide tailored care for specific malignancies [ ].
Infodemiology, the science of the distribution and determinants of information in electronic media, has emerged as a critical field in health informatics [- ]. It focuses on analyzing data from internet sources, mainly social media and search queries, to inform public health and policy. Infoveillance is a subset of infodemiology that involves the systematic monitoring of web-based information for public health purposes [ ]. Using data from search queries and social media platforms, infoveillance provides real-time insights into health-related behaviors and trends, aiding in disease surveillance and public health policy development [ , ].
In their quest for relevant information, most internet users turn to search engines. In the Western world, Google holds a dominant position as the preferred search engine [, ]. Google Trends (GT), a free and accessible tool, presents search statistics derived from Google’s search engine [ ]. These statistics are quantified as relative search volume (RSV), which varies between 0 and 100. On this scale, 100 signifies the peak of interest (100% of the interest in a specific inquiry during a particular period and location), whereas 0 denotes an absence of interest (0%). GT, archiving data from January 2004, enables a concurrent comparison of up to 5 terms. Users can set a region either in a specific country or globally. GT distinguishes between search terms and topics in the search input. Search terms refer to the exact strings of text inputted in GT. GT can correspond the search term with a suggested topic, which includes all searches linked to that specific topic, regardless of the language used [ ]. For instance, inputting the search term “cervix” will yield 3 matched topics: “Cervix,” “Neck,” and “Cervical Cancer.”
GT has emerged as a practical tool for researchers, enabling them to analyze Google users’ interests in specific search terms associated with various phenomena. Some researchers have discovered an association between Google searches for specific cancers and their incidence . GT has also been used to gauge the effects of celebrity deaths owing to cancer on the public’s interest in that specific malignancy [ , ]. Other notable examples of such trends include the interest in melanoma in relation to its prevalence in the population [ ] and the awareness of the importance of colonoscopy in particular countries [ ]. Most recently, Google query statistics have been leveraged to evaluate the decline in interest in cancer screening during the COVID-19 pandemic [ - ].
As the volume of GT studies has increased rapidly, it has become challenging to review all studies comprehensively at once . However, a review can be more focused and examine GT studies within a specific health domain. Moreover, new types of studies have emerged, such as analyses of interest in health-related queries during a pandemic and investigations into the effects of educational campaigns or the death of a celebrity owing to cancer on public awareness in specific countries. Conducting a systematic review of GT studies in oncology is important because it can reveal insights into how digital search behaviors reflect public interest and concerns regarding cancer. In turn, this can guide public health messaging, early detection efforts, and resource allocation. Furthermore, a review in this area could bridge the gap between digital epidemiology and traditional oncology research, providing a more nuanced understanding of public engagement with cancer-related information. To date, a few reviews have characterized medical research using GT [ - ]. However, none of them explicitly focused on oncology. A systematic review may elucidate the use of GT in cancer-related studies, highlight its limitations, and establish best practices for future research.
We aimed to systematically characterize studies related to oncology using GT to describe its utilities and biases.
This was a systematic review. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines on systematic review . The PRISMA 2020 checklist is presented in [ ].
We included all studies using GT to analyze queries related to malignancies, solid mass tumors, blood cancers, or their screening methods (). We excluded studies using only other Google tools, for example, Google AdWords, and those written in non-English languages. Moreover, we excluded conference abstracts from consideration. The abbreviated descriptions often provided in these abstracts do not permit the reconstruction of the necessary search inputs that are crucial for evaluating the methodology of a study using GT.
Criteria for inclusion of studies using Google Trends in the review.
- Used tool: Google Trends
- Health domain: solid tumor, lymphoma, leukemia, multiple myeloma, and their screening method
- Language: English
- Type of paper: original research, brief report, letter to the editor, etc
- Used tool: other tools related to search engines statistics than Google Trends
- Health domain: not using at least one search term or topic related to malignancy or their screening method
- Language: non-English
- Type of paper: conference abstract
We used the PubMed search engine to search for studies on oncology-related GT analysis. The search was performed on the PubMed engine on August 1, 2022. The PubMed search input was the following: “Google trends” AND (“oncology” OR “cancer” OR “malignancy” OR “tumor” OR “lymphoma” OR “multiple myeloma” OR “leukemia”). Two authors (JC and MK) independently screened the titles and abstracts of potential articles. All discrepancies were referred by PS. The PRISMA flow diagram is presented in. We obtained 120 studies for the title and abstract screening. Furthermore, we excluded 33 records, 2 were additionally excluded because of inaccessible full-version text, and 85 articles were thoroughly read. Finally, we included 85 studies for the final review.
Evaluation of Studies
The included articles were carefully read and analyzed by one of the authors (JC) who retrieved all essential details. We collected the following details: title, DOI code, authors’ countries, year of publication, aims, aims classification, study category (prophylaxis, awareness month, celebrity death, COVID-19, and others), malignancies considered, analysis of topics or search terms, regions and period analyzed, statistical reproducibility method used, confrontation of GT results with real-world data (eg, with epidemiological data), principal findings, and sensitivity analysis. We classified aims (causal interference, description, surveillance, and other) based on the classification used in the review by Nuti et al . After the preliminary screening of the included articles, 2 authors (MK and JC) formulated a classification scheme for the studies. The main goal of the classification was to distinguish the particular group of studies that used GT. This scheme, which was later approved by author PS, divided all the studies into 5 distinct categories: those related to prophylaxis methods; those related to awareness events (such as Pink October); those related to a celebrity (eg, a death or announcement of cancer diagnosis); those related to the COVID-19 pandemic; and finally, a category for nonspecific studies, which were classified as “Others.” The reproducibility of the study was determined by the authors’ transparency in providing specific details about their search input. This includes information if the search terms or topics were used, the region analyzed, the period of analysis, and whether countries with low or no low search volume were included if the region was set to “Worldwide.” These details are crucial for reproducing the study’s results. The complete characteristics of the studies are presented in .
Studies using GT are retrospective and involve aggregated data of Google users without details, for example, sex and age. Nuti et al  addressed 2 sources of potential bias in GT studies: search strategy and validation of the studies. In this study, we analyzed the following sources of bias: (1) using search terms instead of topics, (2) lack of confrontation of GT results with real-world data, and (3) absence of a sensitivity analysis.
We conducted a descriptive statistical analysis. All categorical variables were presented as numbers and percentages, whereas all numerical variables were expressed as medians along with their IQRs. Data manipulation, calculations, and visualizations were performed using the R-programing language 3.6.1 (R Foundation for Statistical Computing).
This is a systematic review; thus, the paper did not require ethical committee’s approval.
We included 85 articles for our final analysis. Furthermore, 10 examples of the included studies are presented in. Of the 85 articles, in 47 (55%) articles, at least 1 author was from the United States. Furthermore, at least 1 author in 5 articles was affiliated with institutions in Australia, Brazil, or the Philippines. Furthermore, 4 articles each had at least 1 author from Germany, Ireland, Turkey, or the United Kingdom. Three articles included authors from Austria, China, Italy, or Japan. In 2 articles, at least 1 author was from Canada, France, India, or Malaysia. Finally, each article had an author from Iran, Kuwait, the Netherlands, New Zealand, Poland, Portugal, Romania, or Spain. None of the authors were from Africa or Central America.
|Study, year||Aims||Aims classification||Study category||Search inputs||Region analyzed||Period analyzed||Statistical analysis||Confrontation with real- world data||Principal findings|
|Mondia et al , 2022||Description of the pattern of web search queries of the keywords related to neoplasms of the CNSa||Description||Celebrity-related||Search terms: “Brain tumor” (also as disease), “Brain cancer,” “Central nervous system (CNS) tumor,” “glioma” (also as topic), “Glioblastoma” (also as genetic disorder), “astrocytoma” (also as topic), “oligodendroglioma,” “CNS Lymphoma,” “Medulloblastoma” (also as topic), “meningioma” (also as medical condition), “temozolomide” (also as medication), and “oligodendroglioma” (also as topic)||Worldwide||January 2004 to January 2021||Peaks analysis||Yes||“Brain tumor,” “brain cancer,” “glioblastoma” and “glioma” had the highest search volume. RSVb from Google Trends.|
There were no observable trends that could correlate to the rising numbers of brain tumor cases worldwide with the global interest in brain tumors.
|Greiner et al , 2021||Assessment of how COVID-19 affected public interest in mammography, colonoscopy, and HPVc. Assessment of the efficacy of using public interest in cancer screenings||Description||COVID-19||Search terms: “colonoscopy,” “mammogram,” “HPV,” and “pap smear”||Worldwide||September 6, 2015, to August 30, 2020||Peaks analysis, forecasting||No||Public interest in cancer screenings decreased precipitously at the onset of the COVID-19 pandemic, but the decrease in interest in breast and colon cancer screenings slightly underestimated the actual screening use numbers. Google Trends estimated the decrease in mammogram use as 25.8% below the actual value. Similarly, Google Trends estimated the decrease in colon cancer screening use as 9.7% below the true value.|
|Naik et al , 2021||Quantification of the impact of Chadwick Boseman’s death on web-based search interest in colon cancer, checking whether there was an increase in interest in regions of the United States with a greater proportion of Black American residents||Causal interference, description||Celebrity-related||Topics: colorectal cancer, colon cancer screening; terms: colonoscopy, stool test, diagnosis, stool, symptoms, signs, anemia, risk, men, age, black (-panther), African American, treatment, survival, and death||United States||September 2, 2018, to November 29, 2020||Peaks analysis, correlation||Yes||The observed RSVs for the topics of colorectal cancer and colon cancer screening increased by 598% and 707%, respectively, and were on average 121% and 256% greater than expected during the first 3 months after Boseman’s death.|
|Pantel et al , 2021||Determination of the impact of National Colorectal Cancer Awareness Month on rates of screening endoscopies and public interest in colorectal cancer||Surveillance||Awareness month, prophylaxis||Search terms: “colorectal cancer,” “colorectal cancer symptoms,” and “colorectal cancer screening”||United States||January 2004 to July 2019||Correlation, others||Yes||Colorectal cancer screening endoscopy rates were not impacted by the specific month of the year and these rates had no seasonality. However, Google searches related to colorectal cancer were significantly impacted by month of the year, specifically March, with significant seasonality observed in the data. National Colorectal Cancer Awareness Month is associated with an increased public interest in colorectal cancer based on users’ Google search trends.|
|Faoury et al , 2019||Review of Google Trends as a method for investigating internet-based information-seeking behavior related to throat cancer in terms of quantity, content, and thematic analysis||Description||Others||Search terms: “throat cancer,” “cancer,” “HPV,” “laryngeal cancer,” and “head and neck cancer”||Worldwide||2004 to 2015||Peaks analysis||No||Three important peaks in searches for “throat cancer” (and “HPV”) were identified: the first and greatest increase in interest in September 2010, with peaks in June 2013 and in October 2011 also. When comparing “throat cancer” with “laryngeal cancer” and “head and neck cancer,” it was found that there was a significant correlation between the search terms “throat cancer” and “laryngeal cancer” in terms of peaks and timeline changes.|
|Phillips et al , 2018||Characteristics of the relationship between cancer incidence and Google search volumes in the United States for 6 common cancers. Evaluation of the association of search activity with cancer-related public events and celebrity news coverage||Surveillance||Celebrity-related, others||Search terms: “breast cancer,” “prostate cancer,” “colon cancer,” “lung cancer,” “uterine cancer,” and “leukemia”||United States||2004 to 2013||Correlation||Yes||The search volume measured over time noted the term “Dental caries” to be the most searched in Japan, “Gingivitis” in Jordan, “Oral Cancer” in Taiwan, “No Teeth” in Australia, “HIV symptoms” in Zimbabwe, “Broken Teeth” in the United Kingdom, “cleft palate” in the Philippines, and “Toothache” in Indonesia, and the comparison of top 5 searched terms provided the result “Gingivitis” with highest search volume.|
|Rosenkrantz et al , (2016)||Identification of geographic and temporal patterns related to the frequencies of web searches within the United States for information on imaging-based cancer screening tests||Causal interference||Prophylaxis||Search terms: “breast cancer,” “mammography,” “tomosynthesis,” “colon cancer,” “virtual colonoscopy,” “lung cancer,” “lung cancer screening,” “prostate cancer,” “prostate MRI,” and “prostate MRI biopsy”||United States||January 2004 to December 2014||Secular trend, peaks, correlation, others||No||Searches for “mammography” decreased slightly overall, although they peaked in October (Breast Cancer Awareness Month) in most years and spiked in November 2009. Instead, the frequency of searches for “lung cancer screening” decreased slightly from 2006 through 2010, increased rapidly from 2011 through 2014, and exhibited a spike in November 2010 (when the results of the National Lung Screening Trial were released).|
|Noar et al , 2013||Quantification of the effects of pancreatic cancer public figure announcements on web-based cancer information seeking and cancer media coverage||Causal interference||Celebrity-related||Search terms: “pancreatic cancer” or “pancreatic cancers” (pancreatic cancers) and “cancer” or “cancers”||United States||2006 to 2011||Peaks analysis, correlation||No||Most public figures’ pancreatic cancer announcements corresponded with no appreciable change in pancreatic cancer search queries or media coverage. In contrast, Patrick Swayze’s diagnosis was associated with a 285% increase in pancreatic cancer search queries, though it was only weakly associated with increases in pancreatic cancer media coverage. Steve Jobs’ death was associated with a 197% increase in pancreatic cancer queries and a 3517% increase in pancreatic cancer media coverage.|
aCNS: central nervous system.
bRSV: relative search volume.
cHPV: human papillomavirus.
Trends and Journals
The first study that used GT in cancer-related research was published in 2013. In the ensuing years, there has been a significant surge in the annual number of such publications. This trend culminated in 20 publications each in 2020 and 2021. Of the 85 articles, 23 (27%) studies were published in a journal dedicated to oncology, 9 (11%) in a journal about public health issues, 8 (9%) in a journal about dermatology, 18 (21%) in journals with a broad scope (eg, PloS One, BMJ Open, Cureus), and 28 (33%) in other types of journals. Furthermore, 38% (32/85) of the articles were published in open-access journals.
Main Topics and Malignancies
More than half (47/85, 85%) of the studies had descriptive characteristics, mainly characterizing temporal and regional trends (). For example, Zhang et al [ ] described the seasonal interest of Google users in “tobacco” and “lung cancer” in Australia, New Zealand, the United Kingdom, and the United States. Approximately 30% (27/85) of the papers aimed to conduct surveillance analysis. An example of a surveillance study is Brazilian research that evaluated the association between Google searches pertaining to breast cancer and mammograms and the actual number of diagnosed cases and mammograms conducted across various states in Brazil [ ]. Finally, one of the 6 papers assessed the causal interference between specific events and Google searches. For instance, Noar et al [ ] analyzed the effects of public figure announcements of diagnosis or death owing to pancreatic cancer on Google queries ( ).
We classified 22% (19/85) studies as related to prophylaxis, 20% (17/85) as awareness events, 11% (9/85) as celebrity-related, 13% (11/85) as related to COVID-19, and 47% (40/85) as others (). An example of a study on prophylaxis was the research by Kaminski et al [ ], who found an association between the burden of colorectal cancer and interest in colonoscopy among Google users in 60 countries. Several studies have analyzed the association between GT statistics and awareness month; for example, Pink October represents the breast cancer awareness month [ ], and March is an awareness month for colorectal cancer in the United States [ ]. Announcements of the death of celebrities owing to cancer may increase the number of Google queries on cancer, which was reported after the death of Chadwick Boseman owing to colorectal cancer ( ) [ , ]. In recent years, many researchers have analyzed the effects of the COVID-19 pandemic on the interest of Google users with many malignancies. For example, Adelhoefer et al [ ] found that interest in many malignancies decreased during the pandemic’s first months [ ].
The most frequently analyzed cancers were breast cancer (n=28), prostate cancer (n=26), lung cancer (n=18), colorectal cancers (n=18), skin cancers (n=16), and cervical cancer (n=14). In turn, the least frequently were mesothelioma (n=1), penile cancer (n=1), stomach cancer (n=2) or the biliary tract cancer (n=2).
We found that 20% (17/85) of the studies used GT topics instead of search terms. In total, 28% (24/85) of studies incorporated GT statistics for all available countries. In addition, 39% (33/85) of the studies were conducted exclusively for the United States, whereas 35% (30/85) of the studies focused on other countries or a combination of different countries, including the United States. A total of 47% (40/85) of the studies used the most prolonged period available in GT from January 1, 2004.
Most (79/85, 93%) of the studies provided all search input details to reproduce their results. Overall, 40% (34/40) studies compared the GT statistics with real-world data. Almost two-thirds (55/85, 65%) of the studies performed correlation analysis and more than half (43/85, 51%) performed peak analysis. The less popular statistical approaches included secular trends analysis (9/85, 11%), seasonal trends analysis (6/85, 7%), forecasting (4/85, 5%), and others (24/85, 28%).
The authors of only 11% (9/85) of the studies performed a sensitivity analysis. Most studies compared the RSV of analyzed terms to the medical [, - ] and nonmedical search terms [ ]. Another convincing sensitivity analysis involved comparing the results between different countries [ ] or between countries from the northern and southern hemispheres [ ].
We systemically reviewed all studies on malignancies using GT available in PubMed until August 1, 2022. GT appears to be a feasible tool for the infodemiology of cancers. Most of the analyzed studies could be reproduced but had many sources of bias.
Our study found that the number of studies using GT in oncology has constantly been increasing. Most of the included papers came from the Western world, and we did not find any papers from Africa or Central America. Moreover, many available studies have successfully used data from the Global South, for example, Africa [, ]. Previous studies observed that many low-income countries have a low search volume for popular health topics, such as pain [ ] or diets [ ]. This could be related to the lower access to the internet in the Global South.
Furthermore, low-income countries have far fewer productive research facilities than the Western world . However, the number of people using the internet is rapidly increasing in low-income countries [ ]. Therefore, we may expect more data on Google searches in these regions to be available shortly.
The included articles were published in journals with various scopes. Moreover, approximately 1 in 3 papers were published in an open-access journal. It is tempting to hypothesize that articles using GT are usually viewed as a curios subject and often published in wide-scope journals.
In our systematic review, we used the classification of GT articles previously used by Nuti et al . In this study, we observed that most oncological studies using GT were of a descriptive character, a total of <20% analyzed causal interference, and up to 30% focused on surveillance. Nuti et al [ ] reported that 39% of the studies used GT for description, 34% for surveillance, and 27% for causal interference. The proportions of both reviews seem to be similar. However, the review by Nuti et al [ ] included all GT studies on health phenomena from 2009 to 2013, whereas we applied narrower inclusion criteria but included all studies until mid-2022. Nuti et al [ ] defined descriptive studies as those “aimed to describe temporal or geographic trends and general relationships, without reference to a hypothesized causal relationship.” Therefore, we propose that descriptive studies are generally easier for researchers to perform, which explains their popularity.
The analyzed studies differ in terms of study category, which presents many ideas for using GT in oncology-related studies.
A large group of papers took the form of prophylaxis studies. They mainly focused on assessing the interest in oncological screening and a wide range of preventive activities and risk factors for common neoplasms. Most studies analyzed the interest of Google users in cancer screening in the United States. These studies concerned, among others, topics related to the prevention of melanoma and various risk factors of skin cancer known from the literature [- ]. Our systematic review also included 2 papers that analyzed the interest in cancer prevention in Malaysia regarding melanoma [ ] and breast cancer [ ]. Interest in cervical cancer has been examined in Portugal [ ] and Ireland [ ]. However, it should be emphasized that, apart from the study by Kaminski et al [ ] on Google searches for trends and terms related to colonoscopy, no other study has extensively used these topics and analyzed screening programs in many countries.
An interesting application of GT is examining the relationship between a celebrity’s cancer diagnosis and global interest in that specific malignancy. Generally, the announcement of a celebrity’s cancer diagnosis, especially when coupled with premature death, significantly boosts public interest in that specific cancer type. For instance, increased interest in colorectal cancer and colon cancer screening has been linked to the death of actor Chadwick Boseman . Similarly, the diagnoses and deaths of actor Patrick Swayze [ ] and Apple cofounder Steve Jobs [ ] because of pancreatic cancer, as well as actor Ben Stiller’s prostate cancer diagnosis [ ], triggered heightened interest. Moreover, GT analysis is not limited to cancer-related celebrity deaths. Another example in the scientific literature is the study of public interest following the death of actor Harold Allen Ramis because of complications from autoimmune inflammatory vasculitis [ ].
A different approach involves using GT to examine whether social campaigns or cancer awareness months are associated with the interest fluctuations of Google users in specific malignancies. First, GT is a widely available free tool for checking the effectiveness of health promotion events. Data from several studies have shown a correlation between the cancer awareness campaigns and the increased public interest in oncological screening. Such observations have been reported for Pink October and breast screening in Malaysia . Furthermore, several studies have confirmed that events such as breast cancer awareness month were associated with increased interest in this topic among Google users [ ]. Studies confirmed that compared with other months, there was an increase in searches for topics related to breast cancer and mammography in October in all countries [ , ].
However, similar campaigns for lung or prostate cancer did not show a similar relationship . Patel et al [ ] observed that cancer awareness campaigns aimed at men were not associated with a significant increase in interest in topics related to screening, risk factors, or cancer itself. Gender differences might contribute to these findings, as women, who are frequent internet users, are often portrayed as more likely to search for health topics and be more aware of internet use in this area [ ]. Interestingly, studies analyzing data from all countries show the lack of intended effectiveness and increased interest in many cancers [ - ], and studies focusing on specific countries such as Brazil [ ] and New Zealand [ ] have reported increased interest in cancers, such as glaucoma, prostate, and lung cancers. Finally, not only have awareness events related to malignancies been investigated with GT, but a similar study on the effect of World Sepsis Day was conducted as well [ ].
In the context of the COVID-19 pandemic, several studies have analyzed Google users’ interest in cancers, comparing the prepandemic period with the first months or years of the pandemic. These studies have generally found a decrease in interest in many cancers and their screening programs. This decrease in RSVs for cancer-related search terms paralleled a decrease in the number of diagnostic procedures and new cancer diagnoses [, - ]. These findings highlight how GT can be used to study emerging public health problems such as the COVID-19 pandemic. For instance, we present a series of GT studies that suggest that the COVID-19 pandemic might have reduced cancer awareness, potentially leading to increased mortality during the pandemic because of delayed diagnoses. Notably, some of these GT observations were corroborated by the real-world data.
Interestingly, the most commonly analyzed cancers are those (1) with screening programs or (2) the highest prevalence worldwide [, ]. The search terms representing rare malignancies could be queried for by a small population of Google users. Therefore, the trends of rarely typed search terms can be susceptible to irregular fluctuations without specific secular or seasonal patterns [ ]. The trend of search terms with a low search volume could be problematic for the statistical analysis and interpretation of the results. This problem can be mitigated by matching the search terms of a topic in the GT search engine to include more significant regions and queries related to the topic [ ]. However, only one in 5 included GT studies admitted to using topics instead of search terms.
Correlation and peak analyses were the most prevalent among the included studies. These methods are widely used and easy for readers to understand. However, correlation analysis only allows for the detection of associations, and many outcomes may represent incidental findings if they are not compared with real-world data or are supported by sensitivity analysis. Regrettably, only a few studies have analyzed secular or seasonal patterns, and only 4 performed forecasting. Our findings are similar to those of Mavragani et al , who also found that correlation analysis was the most prevalent and forecasting analysis was the least prevalent among studies using GT for analyzing health phenomena [ ].
Furthermore, 40% (34/85) of the papers compared their results with real-world data, and only 9 reviewed studies applied sensitivity analysis [, - ]. In our opinion, many GT research projects, if not compared with real-world data (eg, epidemiological data) or not supported by appropriate sensitivity analyses, serve merely as a form of curiosity. GT data cannot serve as a foundation for new recommendations or epidemiological or eHealth tools in their current form. In this form, the data from GT only incites curiosity, offering, at most, a new perspective on some epidemiological issues. However, GT may provide insights into health phenomena that would otherwise require large-scale observations with uncertain clinical significance.
Whether GT data will be helpful in oncology is, in our opinion, difficult. GT data seem to be much better at dealing with more straightforward issues, for example, analyzing queries representing specific symptoms. Another interesting approach is the analysis of the effects of specific events (COVID-19 or celebrity death) on the interest of Google users in health phenomena. The question remains: under what circumstances is GT data analysis more convenient than conducting an extensive survey? Future studies should focus on translating knowledge from GT data into practical implications for modern oncology.
Strengths and Practical Implications
To the best of our knowledge, this is the first study to explore the use of GT specifically in oncology and hematology. We characterized various studies presenting readers’ feasibility of GT in research related to oncology and hematology. We identified methodological weaknesses in the analyzed reports. Papers using GT data should not only report search inputs appropriately but also report them as proposed by Nuti et al . Furthermore, using topics allows the inclusion of more regions, which increases the value of the results. We also suggest that GT data should be either confronted with real-world data or, if seasonality is analyzed, searches in both hemispheres should be compared. Another interesting approach to sensitivity analysis in GT studies was presented by Gillis et al [ ], who proposed benchmark search terms to exclude random seasonal patterns related to the academic year. Finally, it is worth mentioning that there are no strict rules for sensitivity analysis, but even reanalysis, which excludes certain periods or regions, can increase confidence in the obtained results.
The authors are aware of the limitations of this systematic review. Our systematic review incorporated retrospective studies across a wide range of topics, which presented challenges in their uniform classification. This limited our analysis to descriptive statistics. Furthermore, the field lacks established standards for conducting systematic reviews of studies that use GT data. The novelty of the tool necessitates that researchers exercise considerable diligence. However, this is one of the first systematic reviews of GT and methodological practices are still evolving. In our review, we did not analyze whether the exact results of the papers could be reproduced or whether the authors drew appropriate conclusions. Finally, we opted to include only those studies that were accessible via PubMed. We assumed that the inclusion of (1) conference abstracts and (2) studies from less recognized journals could potentially introduce a selection bias. The abbreviated format of conference abstracts may not provide the necessary details about search inputs, and studies from niche journals may lack rigorous methodology. Consequently, such an approach could lead to the underestimation of the quality of research using GT in relation to malignancies.
The number of studies related to oncology using GT data increases from year to year. The studies included in this systematic review demonstrate a variety of topics, search strategies, and statistical methodologies. The most frequently analyzed cancers were breast, prostate, lung, colorectal, skin, and cervical cancers, potentially reflecting their prevalence in the population or public interest. Although most researchers provided reproducible search inputs, only one-fifth used GT topics instead of search terms, and many studies lacked a sensitivity analysis. Scientists using GT for medical research should ensure the quality of studies by (1) providing a transparent search strategy to reproduce results, (2) preferring to use topics over search terms, and (3) performing robust statistical calculations coupled with sensitivity analysis.
The data set is presented in.
MK and JC collected the data and prepared the figures and tables. JC and MK conducted the statistical analysis. MK and JC were responsible for supplementary material and data interpretation. MK, JC, PS prepared the original manuscript and KS, MR critically reviewed and approved the final manuscript.
Conflicts of Interest
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist.PDF File (Adobe PDF File), 416 KB
Full characteristics of the included studies.XLS File (Microsoft Excel File), 213 KB
- Global Burden of Disease 2019 Cancer Collaboration. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. JAMA Oncol 2022 Mar 01;8(3):420-444 [https://air.unimi.it/handle/2434/893618] [CrossRef] [Medline]
- Schilsky RL. Implementing personalized cancer care. Nat Rev Clin Oncol 2014 Jul 1;11(7):432-438 [CrossRef] [Medline]
- Valero-Aguilera B, Bermúdez-Tamayo C, García-Gutiérrez JF, Jiménez-Pernett J, Cózar-Olmo JM, Guerrero-Tejada R, et al. Information needs and internet use in urological and breast cancer patients. Support Care Cancer 2014 Feb;22(2):545-552 [CrossRef] [Medline]
- Chang K, Berthelet E, Grubbs E, Hamilton S, Karvat A, Tran E, et al. Websites, websites everywhere: how thyroid cancer patients use the internet. J Cancer Educ 2020 Dec;35(6):1177-1183 [CrossRef] [Medline]
- van Uden-Kraan CF, Jansen F, Lissenberg-Witte BI, Eerenstein SE, Leemans CR, Verdonck-de Leeuw IM. Health-related and cancer-related internet use by patients treated with total laryngectomy. Support Care Cancer 2020 Jan;28(1):131-140 [https://europepmc.org/abstract/MED/30993449] [CrossRef] [Medline]
- Shen MJ, Dyson RC, D'Agostino TA, Ostroff JS, Dickler MN, Heerdt AS, et al. Cancer-related internet information communication between oncologists and patients with breast cancer: a qualitative study. Psychooncology 2015 Nov;24(11):1439-1447 [https://europepmc.org/abstract/MED/25631285] [CrossRef] [Medline]
- Zhang Y, Xu P, Sun Q, Baral S, Xi L, Wang D. Factors influencing the e-health literacy in cancer patients: a systematic review. J Cancer Surviv 2023 Apr;17(2):425-440 [https://europepmc.org/abstract/MED/36190672] [CrossRef] [Medline]
- Lleras de Frutos M, Casellas-Grau A, Sumalla EC, de Gracia M, Borràs JM, Ochoa Arnedo C. A systematic and comprehensive review of internet use in cancer patients: psychological factors. Psychooncology 2020 Jan;29(1):6-16 [CrossRef] [Medline]
- Corrales DM, Wells AE, Radecki Breitkopf C, Pena G, Kaplan AL, King LS, et al. Internet use by gynecologic oncology patients and its relationship with anxiety. J Health Commun 2018;23(3):299-305 [CrossRef] [Medline]
- Lee CJ, Gray SW, Lewis N. Internet use leads cancer patients to be active health care consumers. Patient Educ Couns 2010 Dec;81 Suppl:S63-S69 [https://europepmc.org/abstract/MED/20889279] [CrossRef] [Medline]
- Ebel MD, Stellamanns J, Keinki C, Rudolph I, Huebner J. Cancer patients and the internet: a survey among German cancer patients. J Cancer Educ 2017 Sep;32(3):503-508 [CrossRef] [Medline]
- Tan SS, Goonawardene N. Internet health information seeking and the patient-physician relationship: a systematic review. J Med Internet Res 2017 Jan 19;19(1):e9 [https://www.jmir.org/2017/1/e9/] [CrossRef] [Medline]
- Mavragani A. Infodemiology and infoveillance: scoping review. J Med Internet Res 2020 Apr 28;22(4):e16206 [https://www.jmir.org/2020/4/e16206/] [CrossRef] [Medline]
- Eysenbach G. Infodemiology and infoveillance: framework for an emerging set of public health informatics methods to analyze search, communication and publication behavior on the internet. J Med Internet Res 2009 Mar 27;11(1):e11 [https://www.jmir.org/2009/1/e11/] [CrossRef] [Medline]
- Eysenbach G. Infodemiology and infoveillance tracking online health information and cyberbehavior for public health. Am J Prev Med 2011 May;40(5 Suppl 2):S154-S158 [CrossRef] [Medline]
- Mackey T, Baur C, Eysenbach G. Advancing infodemiology in a digital intensive era. JMIR Infodemiology 2022 Feb 14;2(1):e37115 [https://infodemiology.jmir.org/2022/1/e37115/] [CrossRef] [Medline]
- Cai O, Sousa-Pinto B. United States influenza search patterns since the emergence of COVID-19: infodemiology study. JMIR Public Health Surveill 2022 Mar 03;8(3):e32364 [https://publichealth.jmir.org/2022/3/e32364/] [CrossRef] [Medline]
- Barros JM, Duggan J, Rebholz-Schuhmann D. The application of internet-based sources for public health surveillance (infoveillance): systematic review. J Med Internet Res 2020 Mar 13;22(3):e13680 [https://www.jmir.org/2020/3/e13680/] [CrossRef] [Medline]
- Capala M. Global search engine market share for 2018 in the top 15 GDP nations. Medium. 2018 Aug 28. URL: https://medium.com/@SearchDecoder/global-search-engine-market-share-for-2018-in-the-top-15-gdp-nations-2cf65c11e5f5 [accessed 2019-12-11]
- Global search engine market share 2022. Statista. URL: https://www.statista.com/statistics/216573/worldwide-market-share-of-search-engines/ [accessed 2022-12-27]
- Google trends homepage. Google Trends. URL: https://trends.google.com/trends [accessed 2023-05-22]
- Compare Trends search terms - Trends Help. Google. URL: https://support.google.com/trends/answer/4359550?hl=en [accessed 2022-12-10]
- Phillips CA, Barz Leahy A, Li Y, Schapira MM, Bailey LC, Merchant RM. Relationship between state-level google online search volume and cancer incidence in the United States: retrospective study. J Med Internet Res 2018 Jan 08;20(1):e6 [https://www.jmir.org/2018/1/e6/] [CrossRef] [Medline]
- Kahlam A, Chowdhury S, Kahlam J, Amer K, Ahlawat S. The Boseman effect: a missed opportunity? Cureus 2022 May;14(5):e24959 [https://europepmc.org/abstract/MED/35706736] [CrossRef] [Medline]
- Noar SM, Ribisl KM, Althouse BM, Willoughby JF, Ayers JW. Using digital surveillance to examine the impact of public figure pancreatic cancer announcements on media and search query outcomes. J Natl Cancer Inst Monogr 2013 Dec;2013(47):188-194 [CrossRef] [Medline]
- Tas F, Erturk K. Google searching as an indicator of population's interest in melanoma: a comparative study in Google Trends. Dermatol Ther 2020 Nov;33(6):e14421 [CrossRef] [Medline]
- Kaminski M, Marlicz W, Koulaouzidis A. Googling on colonoscopy: a retrospective analysis of search engine statistics. Clin Exp Gastroenterol 2020;13:397-405 [https://europepmc.org/abstract/MED/33061518] [CrossRef] [Medline]
- Greiner B, Tipton S, Nelson B, Hartwell M. Cancer screenings during the COVID-19 pandemic: an analysis of public interest trends. Curr Probl Cancer 2022 Feb;46(1):100766 [CrossRef] [Medline]
- Snyder A, Jang S, Nazari IS, Som A, Flores EJ, Succi MD, et al. Google search volume trends for cancer screening terms during the COVID-19 pandemic. J Med Screen 2021 Jun 04;28(2):210-212 [CrossRef] [Medline]
- Kamiński M, Skrzypczak P, Staszewski R, Roszak M. Effects of the COVID-19 pandemic on the interest of Google queries in cancer screening and cancers: a retrospective study. Cancers (Basel) 2023 Jan 19;15(3):617 [https://www.mdpi.com/resolver?pii=cancers15030617] [CrossRef] [Medline]
- Mavragani A, Ochoa G, Tsagarakis KP. Assessing the methods, tools, and statistical approaches in Google trends research: systematic review. J Med Internet Res 2018 Nov 06;20(11):e270 [https://www.jmir.org/2018/11/e270/] [CrossRef] [Medline]
- Bellaire CP, Rutland JW, Sayegh F, Pesce RR, Tijerina JD, Taub PJ. Going viral: a systematic review of Google trends in plastic surgery and a recommended framework for its use. Aesthet Surg J 2021 Nov 12;41(12):NP2034-NP2043 [CrossRef] [Medline]
- Nuti SV, Wayda B, Ranasinghe I, Wang S, Dreyer RP, Chen SI, et al. The use of google trends in health care research: a systematic review. PLoS One 2014;9(10):e109583 [https://dx.plos.org/10.1371/journal.pone.0109583] [CrossRef] [Medline]
- Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021 Mar 29;372:n71 [http://www.bmj.com/lookup/pmidlookup?view=long&pmid=33782057] [CrossRef] [Medline]
- Mondia MW, Espiritu AI, Jamora RD. Brain tumor infodemiology: worldwide online health-seeking behavior using Google Trends and Wikipedia pageviews. Front Oncol 2022;12:855534 [https://europepmc.org/abstract/MED/35515112] [CrossRef] [Medline]
- Greiner B, Lee M, Nelson B, Hartwell M. The pink elephant in the room: declining public interest in breast cancer and the impact of marketing efforts. J Cancer Policy 2021 Jun;28:100287 [CrossRef] [Medline]
- Naik H, Johnson MD, Johnson MR. Internet interest in colon cancer following the death of Chadwick Boseman: infoveillance study. J Med Internet Res 2021 Jun 15;23(6):e27052 [https://www.jmir.org/2021/6/e27052/] [CrossRef] [Medline]
- Pantel HJ, Kleiman DA, Kuhnen AH, Marcello PW, Stafford C, Ricciardi R. Has National Colorectal Cancer Awareness Month increased endoscopy screening rates and public interest in colorectal cancer? Surg Endosc 2021 Jan;35(1):398-405 [CrossRef] [Medline]
- Faoury M, Upile T, Patel N. Using Google Trends to understand information-seeking behaviour about throat cancer. J Laryngol Otol 2019 Jul;133(7):610-614 [CrossRef] [Medline]
- Rosenkrantz AB, Prabhu V. Public interest in imaging-based cancer screening examinations in the United States: analysis using a web-based search tool. AJR Am J Roentgenol 2016 Jan;206(1):113-118 [CrossRef] [Medline]
- Zhang Z, Zheng X, Zeng DD, Leischow SJ. Information seeking regarding tobacco and lung cancer: effects of seasonality. PLoS One 2015 Mar 17;10(3):e0117938 [https://dx.plos.org/10.1371/journal.pone.0117938] [CrossRef] [Medline]
- Adelhoefer S, Berning P, Solomon SB, Maybody M, Whelton SP, Blaha MJ, et al. Decreased public pursuit of cancer-related information during the COVID-19 pandemic in the United States. Cancer Causes Control 2021 Jun;32(6):577-585 [https://europepmc.org/abstract/MED/33683506] [CrossRef] [Medline]
- Narayanan S, Lazar Neto F, Tanco K, Lopez G, Liu W, Bruera E, et al. Cannabidiol (CBD) oil, cancer, and symptom management: a Google trends analysis of public interest. J Altern Complement Med 2020 Apr;26(4):346-348 [https://europepmc.org/abstract/MED/31971821] [CrossRef] [Medline]
- Callaghan 3rd DJ. Use of Google Trends to examine interest in Mohs micrographic surgery: 2004 to 2016. Dermatol Surg 2018 Feb;44(2):186-192 [CrossRef] [Medline]
- Blasco MA, Svider PF, Tenbrunsel T, Vellaichamy G, Yoo GH, Fribley AM, et al. Recent trends in oropharyngeal cancer funding and public interest. Laryngoscope 2017 Jun;127(6):1345-1350 [CrossRef] [Medline]
- Boehm A, Pizzini A, Sonnweber T, Loeffler-Ragg J, Lamina C, Weiss G, et al. Assessing global COPD awareness with Google Trends. Eur Respir J 2019 Jun;53(6):1900351 [http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=31097517] [CrossRef] [Medline]
- Zhang H, Wang Y, Zheng Q, Tang K, Fang R, Wang Y, et al. Research interest and public interest in Melanoma: a bibliometric and Google Trends analysis. Front Oncol 2021;11:629687 [https://europepmc.org/abstract/MED/33680968] [CrossRef] [Medline]
- Nsoesie EO, Oladeji O, Abah AS, Ndeffo-Mbah ML. Forecasting influenza-like illness trends in Cameroon using Google Search Data. Sci Rep 2021 Mar 24;11(1):6713 [https://doi.org/10.1038/s41598-021-85987-9] [CrossRef] [Medline]
- Anderson JM, Stafford AL, Johnson AL, Hartwell M, Jellison S, Vassar M. Is World Malaria Day an effective awareness campaign? An evaluation of public interest in malaria during World Malaria Day. Trop Med Int Health 2020 Nov;25(11):1416-1421 [https://onlinelibrary.wiley.com/doi/10.1111/tmi.13480] [CrossRef] [Medline]
- Kamiński M, Łoniewski I, Marlicz W. "Dr. Google, I am in pain"-global internet searches associated with pain: a retrospective analysis of Google Trends data. Int J Environ Res Public Health 2020 Feb 04;17(3):954 [https://www.mdpi.com/resolver?pii=ijerph17030954] [CrossRef] [Medline]
- Kamiński M, Skonieczna-Żydecka K, Nowak JK, Stachowska E. Global and local diet popularity rankings, their secular trends, and seasonal variation in Google Trends data. Nutrition 2020 Nov;79-80:110759 [CrossRef] [Medline]
- Gross domestic spending on R and D. OECD Data. URL: http://data.oecd.org/rd/gross-domestic-spending-on-r-d.htm [accessed 2022-12-27]
- How many people use the internet in 2022? Oberlo. URL: https://www.oberlo.com/statistics/how-many-people-use-internet [accessed 2022-12-21]
- Hopkins ZH, Secrest AM. Public health implications of Google searches for sunscreen, sunburn, skin cancer, and melanoma in the United States. Am J Health Promot 2019 May;33(4):611-615 [CrossRef] [Medline]
- Hopkins ZH, Secrest AM. An international comparison of Google searches for sunscreen, sunburn, skin cancer, and melanoma: current trends and public health implications. Photodermatol Photoimmunol Photomed 2019 Mar;35(2):87-92 [CrossRef] [Medline]
- Kwan Z, Yong SS, Robinson S. Analysis of internet searches using Google Trends to measure interest in sun protection and skin cancer in selected South-East Asian populations. Photodermatol Photoimmunol Photomed 2020 Mar;36(2):83-89 [CrossRef] [Medline]
- Seth D, Gittleman H, Barnholtz-Sloan J, Bordeaux JS. Association of socioeconomic and geographic factors with Google Trends for tanning and sunscreen. Dermatol Surg 2018 Feb;44(2):236-240 [CrossRef] [Medline]
- Mohamad M, Kok HS. Using Google Trends data to study public interest in breast cancer screening in Malaysia. Asian Pac J Cancer Prev 2019 May 25;20(5):1427-1432 [https://europepmc.org/abstract/MED/31127903] [CrossRef] [Medline]
- Passos MZ, da Silva-Filho AL, Brandão WC, Meinberg MF, Werneck RA. Evaluating the quality of HPV vaccine-related information on the Portuguese internet. Hum Vaccin Immunother 2022 Nov 30;18(6):2104571 [https://europepmc.org/abstract/MED/35881926] [CrossRef] [Medline]
- Ryan PM, Ryan CA. Mining Google Trends data for health information: the case of the Irish "CervicalCheck" screening programme revelations. Cureus 2019 Aug 29;11(8):e5513 [https://europepmc.org/abstract/MED/31687289] [CrossRef] [Medline]
- Wang K, Lewis G. Insights and strategies to revive brachytherapy using social media: a Google Trends analysis. Cureus 2022 Jun;14(6):e25664 [https://europepmc.org/abstract/MED/35812542] [CrossRef] [Medline]
- Bragazzi NL, Watad A, Brigo F, Adawi M, Amital H, Shoenfeld Y. Public health awareness of autoimmune diseases after the death of a celebrity. Clin Rheumatol 2017 Aug;36(8):1911-1917 [CrossRef] [Medline]
- Nishimura Y, Acoba JD. Impact of breast cancer awareness month on public interest in the United States between 2012 and 2021: a Google Trends analysis. Cancers (Basel) 2022 May 21;14(10):2534 [https://www.mdpi.com/resolver?pii=cancers14102534] [CrossRef] [Medline]
- Patel MS, Halpern JA, Desai AS, Keeter MK, Bennett NE, Brannigan RE. Success of prostate and testicular cancer awareness campaigns compared to breast cancer awareness month according to internet search volumes: a Google Trends analysis. Urology 2020 May;139:64-70 [CrossRef] [Medline]
- Gathers D, Pankratz VS, Kosich M, Tawfik B. Using big data to gauge effectiveness of breast cancer awareness month. Prev Med 2021 Sep;150:106695 [https://europepmc.org/abstract/MED/34166676] [CrossRef] [Medline]
- Bidmon S, Terlutter R. Gender differences in searching for health information on the internet and the virtual patient-physician relationship in Germany: exploratory results on how men and women differ and why. J Med Internet Res 2015 Jun 22;17(6):e156 [https://www.jmir.org/2015/6/e156/] [CrossRef] [Medline]
- Johnson BS, Shepard S, Torgeson T, Johnson A, McMurray M, Vassar M. Using Google Trends and Twitter for prostate cancer awareness: a comparative analysis of prostate cancer awareness month and breast cancer awareness month. Cureus 2021 Feb 13;13(2):e13325 [https://europepmc.org/abstract/MED/33738168] [CrossRef] [Medline]
- Kaleem T, Malouff TD, Stross WC, Waddle MR, Miller DH, Seymour AL, et al. Google search trends in oncology and the impact of celebrity cancer awareness. Cureus 2019 Aug 10;11(8):e5360 [https://europepmc.org/abstract/MED/31608195] [CrossRef] [Medline]
- Demirci A, Özgür BC. A Google Trends™ analysis of bladder cancer: determining awareness campaign success, and patients' needs in clinical management. Asian Pac J Cancer Prev 2021 Oct 01;22(10):3115-3120 [https://europepmc.org/abstract/MED/34710986] [CrossRef] [Medline]
- Quintanilha LF, Souza LN, Sanches D, Demarco RS, Fukutani KF. The impact of cancer campaigns in Brazil: a Google Trends analysis. Ecancermedicalscience 2019;13:963 [https://europepmc.org/abstract/MED/31645890] [CrossRef] [Medline]
- Kho A, Niederer R, Wilson G. Exploring the impact of public health campaigns for glaucoma and macular degeneration utilising Google Trends data in a New Zealand setting. N Z Med J 2020 May 08;133(1514):10-15 [Medline]
- Jabaley CS, Blum JM, Groff RF, O'Reilly-Shah VN. Global trends in the awareness of sepsis: insights from search engine data between 2012 and 2017. Crit Care 2018 Jan 17;22(1):7 [https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1914-8] [CrossRef] [Medline]
- Eala MA, Tantengco OA. Global online interest in cervical cancer care in the time of COVID-19: an infodemiology study. Gynecol Oncol Rep 2022 Jun;41:100998 [https://linkinghub.elsevier.com/retrieve/pii/S2352-5789(22)00078-9] [CrossRef] [Medline]
- Cohen SA, Ebrahimian S, Cohen LE, Tijerina JD. Online public interest in common malignancies and cancer screening during the COVID-19 pandemic in the United States. J Clin Transl Res 2021 Dec 28;7(6):723-732 [https://europepmc.org/abstract/MED/34901518] [Medline]
- Khene ZE, Guérin S, Khene F, Pradère B, Roumiguié M, Mathieu R, Members of the French Committee of Urologic Oncology CCAFU. Online public interest in urological cancers during the COVID-19 pandemic: what can "Dr. Google" teach us? Eur Urol Open Sci 2022 Mar;37:73-79 [https://linkinghub.elsevier.com/retrieve/pii/S2666-1683(22)00016-7] [CrossRef] [Medline]
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018 Nov;68(6):394-424 [https://onlinelibrary.wiley.com/doi/10.3322/caac.21492] [CrossRef] [Medline]
- Gillis T, Garrison S. Confounding effect of undergraduate semester-driven "academic" internet searches on the ability to detect true disease seasonality in Google Trends data: Fourier filter method development and demonstration. JMIR Infodemiology 2022 Jul 19;2(2):e34464 [https://infodemiology.jmir.org/2022/2/e34464/] [CrossRef] [Medline]
|GT: Google Trends|
|PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses|
|RSV: relative search volume|
Edited by A Mavragani; submitted 25.03.23; peer-reviewed by H Zhang, S Wei; comments to author 05.05.23; revised version received 24.05.23; accepted 12.06.23; published 04.08.23Copyright
©Mikołaj Kamiński, Jakub Czarny, Piotr Skrzypczak, Krzysztof Sienicki, Magdalena Roszak. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 04.08.2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.