Published on 27.11.17 in Vol 19, No 11 (2017): November
Preprints (earlier versions) of this paper are available at http://preprints.jmir.org/preprint/7468, first published Feb 07, 2017.
Relationship Between the Menstrual Cycle and Timing of Ovulation Revealed by New Protocols: Analysis of Data from a Self-Tracking Health App
Background: There are many mobile phone apps aimed at helping women map their ovulation and menstrual cycles and facilitating successful conception (or avoiding pregnancy). These apps usually ask users to input various biological features and have accumulated the menstrual cycle data of a vast number of women.
Objective: The purpose of our study was to clarify how the data obtained from a self-tracking health app for female mobile phone users can be used to improve the accuracy of prediction of the date of next ovulation.
Methods: Using the data of 7043 women who had reliable menstrual and ovulation records out of 8,000,000 users of a mobile phone app of a health care service, we analyzed the relationship between the menstrual cycle length, follicular phase length, and luteal phase length. Then we fitted a linear function to the relationship between the length of the menstrual cycle and timing of ovulation and compared it with the existing calendar-based methods.
Results: The correlation between the length of the menstrual cycle and the length of the follicular phase was stronger than the correlation between the length of the menstrual cycle and the length of the luteal phase, and there was a positive correlation between the lengths of past and future menstrual cycles. A strong positive correlation was also found between the mean length of past cycles and the length of the follicular phase. The correlation between the mean cycle length and the luteal phase length was also statistically significant. In most of the subjects, our method (ie, the calendar-based method based on the optimized function) outperformed the Ogino method of predicting the next ovulation date. Our method also outperformed the ovulation date prediction method that assumes the middle day of a mean menstrual cycle as the date of the next ovulation.
Conclusions: The large number of subjects allowed us to capture the relationships between the lengths of the menstrual cycle, follicular phase, and luteal phase in more detail than previous studies. We then demonstrated how the present calendar methods could be improved by the better grouping of women. This study suggested that even without integrating various biological metrics, the dataset collected by a self-tracking app can be used to develop formulas that predict the ovulation day when the data are aggregated. Because the method that we developed requires data only on the first day of menstruation, it would be the best option for couples during the early stages of their attempt to have a baby or for those who want to avoid the cost associated with other methods. Moreover, the result will be the baseline for more advanced methods that integrate other biological metrics.
J Med Internet Res 2017;19(11):e391
Awareness of one’s own fertility is considered important in helping women become pregnant in a shorter period of time [- ]. Fertility depends on the menstrual (ovarian) cycle, and in each cycle there is a “fertile window” during which women can conceive [ , , ]. Studies on standard menstrual cycles suggest that the fertile window starts 5 days prior to ovulation and ends on the day of ovulation [ ]. This is essentially consistent with the results of statistical studies [ , ] that estimated the day-specific pregnancy rates; the pregnancy rate starts to increase 8 days prior to ovulation, peaks after 6 days (2 days prior to ovulation), and reaches almost 0 at 2-3 days after ovulation. Hence, in order to be aware of the fertility window, it is important for a woman to be able to predict the next ovulation date in the course of her menstrual cycles.
The “calendar method” of predicting the next ovulation date was developed based on the recognition of cycles in the menstrual period and fertility, in which women record their menstrual cycles for family planning . It may have been one of the most widely recorded personal health information details before the spread of mobile phones and computers. On the other hand, the recent popularity of self-tracking tools realized by ubiquitous and wearable technologies has led people to gather various kinds of self-information ranging from financial behaviors to physical activities [ , ]. These technologies are used to “help people collect personally relevant information for the purpose of self-reflection and gaining self-knowledge” and are referred to as personal informatics systems [ ]. Currently, the classical calendar method of predicting the next ovulation date is integrated into personal informatics systems. There are many mobile phone apps aimed at helping women map their ovulation and menstrual cycles and facilitating successful conception (or avoiding pregnancy) [ , ]. Apps available for these purposes include Ovia Fertility (Ovuline), Glow, OvuView, Ovulation Calendar, Fertility Calendar, My Days, Period Diary, Period Tracker, Maybe Baby, and Fertility Friend [ ]. As Lupton [ ] mentioned, while these apps are grounded on traditional gynecological knowledge, the advantage that some of them claim is a data analytic approach that can provide greater accuracy than more traditional forms of self-tracking. These apps usually ask users to input various biological features (eg, ovulation, sexual intercourse, basal body temperature, state of cervical mucus, body weight, and the timing of menstrual bleeding).
However, it is not known how to process these features numerically to improve the ovulation prediction error. A mixture of knowledge on biological mechanisms and a statistical approach using the newly enabled biological metrics is promising [, ], although it is still an open problem. Instead of pursuing the usage of various biological metrics, we believe that more attention should be paid to other aspects of this dataset, that is, its massiveness. It is a remarkable achievement that mobile phone apps have been able to accumulate menstrual cycle data of a vast number of women. Currently, records of more than 10,000 individuals can be a target of statistical analysis. In this study, we start from calendar-based methods that require only the recording of menstruation to predict the ovulation date [ - ]. For many couples, the calendar-based methods are the simplest options of determining the timing of the menstrual cycle [ ]. Even within the simple prediction framework, a large amount of data potentially allows us to figure out individual differences better than in traditional understanding [ , ].
This study aims to clarify the above points using data obtained from a commercial women’s health care service provided as a mobile phone app in Japan. We extracted approximately 0.1% of all users of the app, resulting in 7043 subjects after data screening. This paper reports on the progressive health data ecosystem in which commercial health care mobile apps generate massive amounts of data. The results of the data analysis give feedback to the app and can be used to improve public health as well.
We screened 150,000 users who wanted to conceive out of a total of 8,000,000 users of a mobile phone app from a commercial women’s health care service, Luna Luna. We used the data of 7043 women who had each recorded at least one menstrual cycle with ovulation date, suggesting that about 5% of women utilize ovulation tests to support their conception. The ovulation date had been determined by one of the methods described in the next paragraph. The total number of cycles was 135,666, and there were 12,731 cycles with an ovulation date. Any cycles in the record that were less than 20 days or greater than 45 days were removed to rule out unnatural cycle length that is due to erroneous or defective input. About 57% (7285) of the cycles had more than 8 records of past menstrual cycles after the screening, which allowed us to analyze the relationship between past and future menstrual cycles. The age distribution of the 7043 women ranged from 20-45 years with a mean of 32.94 years (95% CI 32.04-33.85), which is slightly higher than the mean maternal age of Japanese women at the time of first birth (which was 30.1 years in 2010).
Each user’s personal records consisted of the dates when they recognized menstrual bleeding (onset of menstruation) and the dates when they detected ovulation. In the log file, an identifier is attached to each ovulation record to distinguish its basis (clinical diagnosis/ovulation test kit/other reliable method). In our analysis, only clinical diagnosis‒based (31%) and ovulation test kit‒based (54%) ovulation records were used. Luna Luna does not ask women to record which clinical diagnostic test they used to determine the ovulation date. However, it is noted that the ovulation day in Japan is commonly determined by ultrasound scanning and occasionally with testing of blood luteinizing hormone or estrogen level.
Luna Luna is a total health care service for female mobile phone users in Japan. Luna Luna offers its users predictions of menstrual cycles, fertility, ovulation, and related health care information, based on user-inputted personal records that are sent and stored in its data server. The data are securely stored separately from personally identifiable information. Luna Luna has been provided as a commercial service for more than 10 years since the year 2000. Luna Luna has 7 million subscribers as of 2016 and occupies a leading position among mobile health care services for female users in the Japanese market.
Menstrual Cycles, Timing of Ovulation, Follicular Phases, and Luteal Phases
We express the records of the first day of menstruation of woman i as,
where mi1 is the first day of the most recent menstruation of woman i (i=1, 2,...,N), mi2 is the first day of her second most recent menstruation, and so on. Then, we defined Ci as a series of menstrual cycle lengths of woman i by,
Ci=(ci1,...,ciT–1)=(D(mi1, mi2),...,D(miT–1, miT)),
where cij denotes the j th most recent menstrual cycle of woman i and D(mij, mij+1) denotes a function that gives the number of elapsed days between mij+1 and mij. For simplicity of notation, we define the mean length of the menstrual cycles of woman i over the j th to j’ th cycles as ci*(j, j’)=Σt=j,...,j’cit/(j’–j+1).
Fi is the series of follicular phase lengths of woman i, where each follicular phase length, fij, is defined as follows: assuming we have records of ovulation oij(j=1, 2, ...) between mij and mij+1,
Fi=(..., fij, ...)=(..., D(oij, mij+1), ...).
Thus, the timing of ovulation is fij days after the day of the previous menstruation mij+1. Similarly, the series of luteal phase lengths of woman i, Li, where each luteal phase length is lij, is defined as,
Li=(..., lij, ...)=(..., D(mij–1, oij+1), …).
Here, oij+1 is the day after ovulation and mij–1 is the day before the next menstruation. The timing of ovulation is cij–lij–1 days after the first day of the previous menstruation mij+1. It should be mentioned that the length of records varied among the women. We used Ti to indicate the length of records of woman i.
We investigated the relationships between the length of menstrual cycles and the length of the follicular phases or that of the luteal phases. We also analyzed the relationships between the mean length of past menstrual cycles and the length of the follicular phases or that of the luteal phases because prediction of ovulation date requires an unknown length of the next menstrual cycle.
We evaluated the relevance of three calendar-based methods using our data. The first was the Ogino method , which assumes a fixed length of the luteal phase of 14 days and predicts the ovulation date as [c*]–15 days after the onset of the previous menstruation for a particular woman when the mean length of her menstrual cycles is c* (here [c*] represents c* rounded down to the nearest integer). This implies that the length of the follicular phase in the next cycle is [c*]–15. The Ogino method is the most widespread calendar-based method relied on by Japanese women. The second method is the method proposed by Lamprecht and Grummer-Strawn [ ], which assumes that the length of the next follicular phase is [c*/2], and thus this method predicts a woman’s next ovulation date as [c*/2] days after the onset of the previous menstruation. Here, we call this method as the half cycle length (HCL) method. Because of its simplicity, we chose the HCL method over other calendar-based methods that reflect individual differences in the length of the luteal phase in a menstrual cycle. The third method is the method that was developed in this study and predicts a woman’s next ovulation date as fi(c*) days after the onset of the previous menstruation. As explained in the next section, fi is a linear function that is optimized by using the relationship between the follicular phase length and c *. Hence, we call the third method as the Optimized method.
To analyze the relationship between the timing of ovulation and the mean length of past menstrual cycles, we evaluated the three prediction models for follicular phase length, that is, μOgino, μHCL, and μOPT, which predict the length of the next follicular phase as μOgino(Ci, j, k)=[cij*(k)]–15, μHCL(Ci, j, k)=[cij*(k)/2], and μOPT(Ci, j, k)=[fij(cij*(k))], respectively. Here, cij*(k) is defined as cij*(k)=ci*(j+1. J+k). It should be noted that if k=1, cij*(k) is identical to the nearest cycle length, cij+1.
To predict the timing of ovulation, we used the results of least square fitting between mean cycle length and follicular phase length. The prediction performance of the timing of ovulation using the obtained model, μOPT, and the prediction performances using the Ogino and HCL methods, μOgino and μHCL, respectively, were compared with different allowable prediction error levels, |μ–fij| ≤ 0, 1, 2.
In our analysis, we used a linear model to describe the relationship between an explanatory variable x and a response variable y. For data that consist of multiple data points from each individual, linear models are generally categorized into two types: fixed effect models and random effect models . A fixed effect model is formalized as follows:
δij=1 if i=j else 0,
where δij s are dummy variables. The least square estimate of parameters including dummy variables is obtained as,
where xi*=1/Ti∑t=1,...,Tixit and yi*=1/Ti∑t=1,...,Tiyit. Hence, in this model, different women have different αi for the relationship between x and y, and there is a correlation between α and x. On the other hand, in random effect models, the random component of αi s is included in the random variable μij as follows:
Here, we assumed that xij'=(1, xij) and β'=(α, β). A pooled ordinary least square estimate, βp'=(αp, βp), is obtained as,
However, the result underestimates the covariance structure in μij s, which is described as a matrix,
ωij=ξα2+ξϵ2 if i=j else ξα2.
Using the result of pooled ordinary least square, the generalized least square estimate of parameters that include the effect of covariance, βgls'=(αgls, βgls), is obtained as,
where ωts(–1) is an element of Ω(–1), which is the inverse matrix of Ω. To obtain ξα and ξϵ, we first calculate,
In this paper, we used the Hausman test to determine which of the models better explains the data. In the Hausman test, the percentile value of H=(βgls–βlsdv)2 in a Χ2 distribution with one degree of freedom is calculated, and a random effect model is rejected if the P value is greater than .05.
In our dataset, the mean (95% confidence interval) of the menstrual cycle length, the follicular phase length, and the luteal phase length of the 7043 women over all cycles was 29.76 (24-38), 14.84 (10-23), and 13.91 (10-19) days, respectively. Both the length of the follicular phases and of the luteal phases had a positive correlation with the length of the menstrual cycles (). The Pearson correlation coefficient between the length of the menstrual cycles and the length of the follicular phases or of the luteal phases was .75 (P<.001) and .37 (P<.001), respectively. Hence, both the follicular phase length and luteal phase length had significant positive correlations with the menstrual cycle length. For analysis of the relationship between the length of the menstrual cycles and the length of the follicular phases or of the luteal phases, we applied the random effect model because the P value of the Hausman test was .001. The coefficient (α, β) of the generalized least square estimate was (.501, -.088) for the follicular phase length and (.466, .088) for the luteal phase length.
We then investigated the relationship between the mean length of past cycles and the cycle length, follicular phase length, and luteal phase length of the next menstrual cycle.shows the number of cycles having enough records to calculate cij*(k) for each number of k. For example, there were 11,640 cycles with at least one previous cycle, and there were 7285 cycles having records of 8 past cycles. shows the Pearson correlation coefficients between cij*(k) and the next menstrual cycle length, follicular phase length, and luteal phase length. Both the next cycle length and the follicular phase length had strong correlations with the mean cycle length. Only a weak correlation was found between the mean cycle length and the luteal phase length, although it was statistically significant. We applied the random effect model because the P value of the Hausman test was <.050 for all cases ( ). The coefficient (α, β) of the generalized least square estimate was similar to that calculated for the actual cycle length. In summary, the menstrual cycle length had positive correlations with both the follicular phase length and luteal phase length, although the correlation was less strong with luteal phase length.
The prediction performance of the timing of ovulation using the obtained model, μOPT, was compared with that of μOgino and μHCL. μOPT outperformed μOgino when a woman’s mean cycle length was shorter than 27 days or longer than 31 days (). μOPT outperformed μHCL when a woman’s mean cycle length was less than 28 days. As for the mean accuracy over different mean cycle lengths ( ), μOPT outperformed μOgino in all cases. The prediction performances of μOPT and μHCL were similar when only small numbers of cycles were available to calculate the mean cycle length, whereas μOPT showed an advantage with increasing values of k.
|Cycle length, days||Cycles, n||Mean follicular phase length, days||95% CI||Mean luteal phase length, days||95% CI|
|Mean cycle length, days||k=1||2||3||4||5||6||7||8|
|Next cycle length, days||.543||.574||.584||.589||.589||.593||.592||.592|
|Follicular phase length, days||.506||.526||.537||.547||.547||.546||.548||.547|
|Luteal phase length, days||.109||.129||.138||.135||.137||.144||.140||.140|
|Follicular phase length|
|Luteal phase length|
In this paper, using the data obtained from the Luna Luna service, we evaluated how menstrual cycle length is related to luteal phase length and follicular phase length. As suggested in a previous study , the correlation between length of menstrual cycles and length of follicular phases was stronger than the correlation between length of menstrual cycles and length of luteal phases ( ). Furthermore, there was a positive correlation between the lengths of past and future menstrual cycles ( and ); this suggests that there is regularity in menstrual cycles as claimed by Creinin et al [ ]. A strong positive correlation was also found between the mean length of past cycles and the mean length of follicular phases. Thus, the follicular phase length can be mostly estimated from each woman’s menstrual cycle length. However, the correlation between mean cycle length and luteal phase length was also statistically significant. Our results showed that the random effect model was relevant for modeling the relationship between menstrual cycle length and follicular phase length as well as the relationship between menstrual cycle length and luteal phase length. Furthermore, the random effect model was also relevant for modeling the relationships between mean length of past menstrual cycles and mean length of follicular phases or luteal phases. These results suggest that these relationships are shared among all women without being influenced by personal factors. The existing calendar-based methods (Ogino and HCL methods) did not explain our data well. Against the assumption of the Ogino method, the weak positive correlation between mean cycle length and luteal phase length ( and ) suggests that the luteal phase does not have a constant length among women with mean menstrual cycles of different lengths. This is why the Ogino method was less accurate when a woman’s mean cycle length was shorter than 27 days or longer than 32 days ( ). The HCL method was less accurate when a woman’s mean cycle length was less than 28 days ( ). By taking the average over different mean cycle lengths, the accuracy of the Ogino method was worse than that of the other methods as well ( ). The accuracy of the HCL method was close to that of the Optimized method when there were only a small number of cycles available to calculate the mean cycle length ( ). The Optimized method showed better performance with increasing numbers of available cycles. The Optimized method outperformed the HCL method in explaining the relationship between the mean cycle length and the follicular phase length when a large number of past cycles were available to calculate the mean cycle length. These results showed that the performance of the Optimized method was equivalent to or better than that of the HCL method. Hence, we recommend using the Optimized method to predict the timing of ovulation from the mean length of menstrual cycles if these data are available.
The novelty of our findings is essentially accounted for by the large number of participants. The Ogino method was developed based on the anatomical observation of ovarian follicles of 81 women with cycle lengths of between 23 and 45 days . They reported that there was a variable luteal phase length (12-16 days), while the number of subjects studied was not large enough to identify the more detailed relationship between the lengths of the menstrual cycle, follicular phase, and luteal phase. Three studies with more data reported the mean (95% CI) of the follicular phase length and the luteal phase length as 16.5 (9-23) and 12.4 (8-17) [ ], 15.5 (9-22) and 12.6 (9-17) [ ], and 15.0 (2-21) and 13.5 (7-20) days [ ], respectively. These studies reported only the mean value over all women, except for Fehring et al [ ] who reported positive correlations between menstrual cycle length and follicular phase length or luteal phase length. However, their analysis was based on only 1060 cycles in 141 women. Lamprecht and Grummer-Strawn [ ] suggested that follicular phase length was better estimated by c */2 based on an analysis of 7514 cycles in 1062 women. In contrast, our study analyzed more than 65,000 cycles, which is 61 and 8.5 times greater than what was used in the studies of Fehring et al [ ] and Lamprecht and Grummer-Strawn [ ], respectively. This study allowed us to capture the relationships between length of menstrual cycle, follicular phase, and luteal phase in more detail.
Recently, mobile health information technology—known as “digital health,” “eHealth,” or “mHealth”—has been used in medicine and public health in various ways [- ]. With the recent spread of smartphones and other mobile devices (eg, 77% of US adults [ ], 62.6% of Japanese [ ], and 62% of Chinese [ ] own smartphones), digital health technologies have begun to be adapted for a wide variety of purposes. The mHealth information technologies are one of the origins of the advanced movement called “Quantified Self”, which stresses the role of patients or consumers in medicine and public health [ , , ]. Quantified-self refers to an individual who is engaged in the self-tracking of any kind of biological, physical, behavioral, or environmental information [ ]. These movements are now spreading among people who were not familiar with such technologies before [ ]. For example, 60% of US adults are currently tracking their weight, diet, or exercise routine, and 33% are monitoring other factors such as blood sugar, blood pressure, headaches, or sleep patterns [ ]. There are 165,000 mobile phone health apps available on the market [ ]. The self-tracked health data are regarded as the key to realizing personalized medicine and health maintenance [ ].
Our analysis lacked complete profile data for all subjects and the dataset had inevitable selection bias. Moreover, menstrual bleeding started in the middle of the night in some cases—the date taken as the menstrual start day depended on the user’s subjective choice. However, we believe that having a large-scale dataset available to carry out investigations on women’s health overcomes such limitations.
Our study demonstrated how the present calendar methods of predicting the ovulation date were improved by the better grouping of women, which can be supported statistically only with massive numbers of subjects. Because calendar methods require only the timing of menstruation, one of the calendar methods would be the best option for couples during the early stages of their attempt to have a baby or for those who want to avoid the cost associated with other methods. Moreover, the results of the calendar method will be the baseline for more advanced methods that integrate other biological metrics. The mobile phone‒based health care services are very efficient in obtaining large datasets because they offer easy ways for users to input and manage their personal data. This recently enabled data collection framework is complementary to existing well-controlled experimental methods and will contribute to the testing of medical hypotheses that previously could not be studied due to insufficient numbers of subjects. Users benefit from newly developed medical knowledge by using mobile phone‒based services without the need to learn intricate calculations. For medical personnel and researchers, the records accumulated by these commercial services can be a useful source of data for analysis after appropriate anonymity processing. Thus, in the mobile phone‒based services that aim at facilitating conception (or contraception), medical specialists and users form a knowledge-improving cycle that can provide quick feedback to the users from the emerging analysis results. Such systems, including other mobile phone health care services, are strongly expected to contribute to comprehensive health care for people of all ages.
We would like to thank Cornelis B Lambalk for valuable comments and suggestions. MTI Ltd provided support in the form of salaries for authors KS and II but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
The study idea was conceived by all authors. The study protocol and analysis were developed by KS and II. The first draft was written by KS and II. SS participated in the revision of the paper and critical discussions. All authors approved the final draft.
Conflicts of Interest
KS and II are employees of MTI Ltd. In addition, KS and II have a patent (Japan Patent Office, No. P5998307) pending.
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|HCL: half cycle length|
|SNS: social networking service|
Edited by G Eysenbach; submitted 07.02.17; peer-reviewed by K Blake, A Rapp; comments to author 20.04.17; revised version received 11.08.17; accepted 08.09.17; published 27.11.17
©Satoshi Sohda, Kenta Suzuki, Ichiro Igari. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.11.2017.
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