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Journal of Medical Internet Research


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Published on 08.03.18 in Vol 20, No 3 (2018): March

Preprints (earlier versions) of this paper are available at, first published Dec 22, 2017.

This paper is in the following e-collection/theme issue:

    Original Paper

    Internet-Based Cognitive Behavioral Therapy for Symptoms of Depression and Anxiety Among Patients With a Recent Myocardial Infarction: The U-CARE Heart Randomized Controlled Trial

    1Clinical Psychology in Healthcare, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden

    2Department of Psychology, Uppsala University, Uppsala, Sweden

    3Family Medicine and Preventive Medicine, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

    4Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

    5Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden

    Corresponding Author:

    Fredrika Norlund, PhD (Psych)

    Clinical Psychology in Healthcare

    Department of Women's and Children's Health

    Uppsala University

    Akademiska sjukhuset

    Uppsala, 75185


    Phone: 46 737441304



    Background: Symptoms of depression and anxiety are common after a myocardial infarction (MI). Internet-based cognitive behavioral therapy (iCBT) has shown good results in other patient groups.

    Objective: The aim of this study was to evaluate the effectiveness of an iCBT treatment to reduce self-reported symptoms of depression and anxiety among patients with a recent MI.

    Methods: In total, 3928 patients were screened for eligibility in 25 Swedish hospitals. Of these, 239 patients (33.5%, 80/239 women, mean age 60 years) with a recent MI and symptoms of depression or anxiety were randomly allocated to a therapist-guided, 14-week iCBT treatment (n=117), or treatment as usual (TAU; n=122). The iCBT treatment was designed for post-MI patients. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS) 14 weeks post baseline, assessed over the internet. Treatment effect was evaluated according to the intention-to-treat principle, with multiple imputations. For the main analysis, a pooled treatment effect was estimated, controlling for age, sex, and baseline HADS.

    Results: There was a reduction in HADS scores over time in the total study sample (mean delta=−5.1, P<.001) but no difference between the study groups at follow-up (beta=−0.47, 95% CI −1.95 to 1.00, P=.53). Treatment adherence was low. A total of 46.2% (54/117) of the iCBT group did not complete the introductory module.

    Conclusions: iCBT treatment for an MI population did not result in lower levels of symptoms of depression or anxiety compared with TAU. Low treatment adherence might have influenced the result.

    Trial Registration: NCT01504191; (Archived at Webcite at

    J Med Internet Res 2018;20(3):e88





    Symptoms of depression and anxiety are common after an acute myocardial infarction (MI). Approximately 8% to 30% of patients with a recent MI report depressive symptoms [1], and 13% to 60% of patients report anxiety symptoms [2], with anxiety often co-occurring with symptoms of depression [3]. Post-MI symptoms of depression, anxiety or both are associated with an increased risk of adverse cardiac outcomes [2,4] and reduced quality of life [5].

    Several pharmacological treatment trials, with and without psychological support, have been found to reduce symptoms of depression and anxiety among patients with acute coronary syndrome [6,7]. Purely psychological treatment studies have also been effective in reducing symptoms of depression and anxiety in patients with coronary heart disease [8]. Effective treatments have been characterized by adopting techniques used in cognitive behavioral therapy (CBT) [9]. To improve access to effective support, increased engagement in eHealth solutions within the cardiac community has been called upon [10], with internet-based CBT (iCBT) representing an eHealth solution that may improve access to acceptable, effective, and cost-effective psychological treatment [11]. iCBT has been found to reduce symptoms of depression and anxiety among adults with common mental health difficulties [12]. In addition, evidence suggests that guided iCBT may improve disease-related functioning and reduce psychological distress in patients with chronic somatic conditions [13]. Furthermore, preliminary evidence suggests that iCBT may reduce symptoms of depression and anxiety for adults with high cardiovascular risk [14]. However, there is limited knowledge regarding the effectiveness and acceptability of iCBT for symptoms of depression and anxiety among MI patients recruited in a clinical setting.


    The aim of this randomized controlled trial (RCT) was to evaluate the effectiveness of therapist-guided iCBT versus usual care in patients with a recent MI and comorbid symptoms of depression and anxiety.


    Study Design

    The U-CARE Heart study is an RCT comparing therapist-guided iCBT with treatment as usual (TAU). A study protocol, including an internal pilot study, has previously been published [15]. Patients (n=239) were recruited from 25 cardiac clinics in Sweden from September 2013 to December 2016. Outcome measurements were collected at baseline (6-10 weeks post-MI) and at post-treatment follow-up (14 weeks post baseline).

    The study protocol was approved by the regional ethics committee in Uppsala (2011/217) and registered at on January 5, 2012 (NCT01504191). Three protocol design modifications were made during the ongoing trial. First, the inclusion criteria threshold was lowered from ≥10 to >7 on either of the 2 Hospital Anxiety and Depression Scale (HADS) [16] subscale scores (March 5, 2014), to increase the recruitment rate (after having recruited only 7 patients). Second, minor changes were made to the introduction module after completion of the internal pilot trial including the first 20 patients [15]. Third, a mobile device version of the treatment was launched after 63 patients had been randomized to iCBT, representing 53.8% (63/117) of the total allocated to this trial arm (February 29, 2016).


    Inclusion criteria were as follows: (1) <75 years of age, (2) recent MI <3 months, and (3) score >7 on one or both of the 2 HADS subscales. Exclusion criteria were as follows: (1) scheduled for coronary artery bypass surgery, (2) unable to use computer or internet or email or mobile phone, (3) unable to read Swedish, (4) expected to live for <1 year, (5) anticipated to show poor compliance (eg, substance abuse or not showing up to the cardiac nurse visit), (6) self-reported severe depression or suicidal ideation (Montgomery-Asberg Depression Rating Scale-Self Rated [MADRS-S] total score >34 or MADRS-S item 9>3) [17], and (7) participating in another behavioral intervention trial. Patients in both study arms had access to TAU.


    Patients were identified and screened for eligibility during a routine visit to a cardiac nurse at 1-8 weeks following their MI. Nurses provided brief trial information and logged all consecutive patients matching the inclusion criteria. U-CARE research staff at the coordinating center (Uppsala) called eligible patients to provide further study information. Written information and an informed consent form were sent to patients via postal service. Patients providing informed consent subsequently received an email with a username and password to access a secure internet-based portal to complete the Web-based baseline assessments. Patients reporting symptoms of depression or anxiety >7 on 1 or both of the 2 HADS subscales were randomized to iCBT or TAU. Patients were randomly assigned (stratified by the clinical recruiting center) with a 1:1 allocation, using a computer-generated code. Randomization occurred automatically in the internet-based portal, with patients receiving an email to inform them of condition assignment.

    Patients indicating severe depression or suicidal ideation were contacted via phone and referred to appropriate care and excluded from the trial. Patients who did not complete the Web-based baseline or follow-up assessment were reminded by SMS text messages (short message service, SMS), with research staff blind to group allocation telephoning patients who did not complete the assessment within 1 week of receiving the SMS reminder. Paper-and-pencil assessment forms were sent to patients on request or if they were not reached by telephone.

    Table 1. Description of the internet-based cognitive behavioral treatment.
    View this table


    Internet-Based Cognitive Behavioral Therapy

    The treatment consisted of a 14-week, therapist-guided, tailored CBT intervention delivered via a secure internet-based portal (U-CARE-portal). See Multimedia Appendix 1 for a sitemap and Multimedia Appendix 2 for a screenshot of the portal. The treatment was developed by licensed psychologists, in consultation with patients with a history of depression and anxiety post-MI. The treatment included 10 modules with different themes, adapted to MI patients (Table 1). The introduction module was compulsory, and thereafter, patients were able to choose which modules to work with, as informed by previous research suggesting tailored iCBT provides patients with more control while maintaining treatment quality [18]. Each module contained 2 to 4 treatment steps, with each step including a PDF with text-based psychoeducation, and 1 to 2 homework assignments. Patients were recommended to work with 1 step per week during the treatment period. Homework assignments consisted of self-monitoring, skills training, and engagement in exercises based on CBT techniques (Table 1). Modules were considered complete when all homework assignments within a module were sent to the therapist for feedback. In addition, the iCBT treatment included a library with supplementary material and video clips of interviews conducted with post-MI patients concerning coping with common psychological reactions post-MI. Patients also had access to a discussion board where they could communicate with other patients randomized to the treatment arm.

    Therapist Support in Internet-Based Cognitive Behavioral Therapy

    Each patient was assigned 1 of the 3 available therapists, who were all licensed psychologists specialized in CBT. Each therapist provided feedback on homework assignments via the portal. The purpose of feedback was to express empathy, encourage work with the treatment, and reinforce treatment activity, all of which has been found to correlate with adherence and outcome [19]. Patients were able to contact their therapist at any time, with therapist responses provided within 48 hours. Patients who were inactive for more than 1 week were contacted by their therapist via telephone, with SMS reminders sent if they were unable to be reached via telephone. Motivational interviewing techniques were used during telephone calls to resolve any identified barriers regarding treatment inactivity. Occasionally, telephone calls included explanations regarding treatment module content; however, calls were not therapeutic and focused on working directly with the material. Telephone call duration ranged between 5 and 30 min. Furthermore, technical support provided by research staff (blinded to allocation) was available via telephone and email.

    Treatment as Usual

    Patients were treated by the local health care system according to international guidelines regardless of treatment allocation. TAU usually includes secondary preventive interventions (eg, information about risk factors and lifestyle changes), cardiac rehabilitation activities (eg, physical exercise), and psychosocial support (eg, counseling if available). Psychotropic medication was not restricted by study participation.


    Patient Characteristics

    Sociodemographic data were obtained from baseline assessments. Medical and risk factor data were obtained from the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies, a Swedish nation-wide quality register) databases RIKS-HIA (Register of Information and Knowledge about Swedish Heart Intensive Care Admissions) and SEPHIA (Secondary Prevention after Heart Intensive Care Admission), covering over 90% of all MIs in Sweden [20].

    Primary Outcome

    HADS-total score (HADS-T) was the primary outcome measure of self-reported symptoms of depression and anxiety, consisting of 14 items divided equally on 2 subscales: anxiety (HADS-A) and depression (HADS-D). Each item is rated on a 4-point Likert scale, resulting in a total score of 42. Higher scores indicate more severe symptoms, with scores above 7 on either subscale indicating mild symptoms [16]. HADS is a reliable and valid measurement of symptom severity and can detect cases of depression and anxiety in different populations [21]. Several studies support the validity of Web-based administration of HADS [22].

    Secondary Outcomes

    MADRS-S was used to screen for severe depression and suicidal ideation before inclusion and as a secondary outcome measure of self-reported depression [17]. The scale consists of 9 items, with each item rated on a 7-point Likert scale, with a total score of 54. Higher scores indicate a higher level of depressive symptoms. The MADRS-S has adequate psychometric properties administered via both paper-and-pencil assessment and the internet [23].

    The Behavioral Activation for Depression Scale-Short Form (BADS-SF) was used as a secondary outcome measure of self-reported symptoms of depression [24]. The scale has 9 items and 2 subscales: avoidance and activation. Each item is rated on a 7-point Likert scale, with a total score of 54. Higher scores indicate less symptoms of depression. The BADS-SF has shown good reliability and validity, predictive validity, and ability to detect clinically relevant changes [24].

    Cardiac anxiety was assessed by the Cardiac Anxiety Questionnaire (CAQ) [25]. The scale consists of 18 items and 3 subscales: fear, avoidance, and focus on cardiac-related stimuli and sensations. Each item is rated on a 4-point Likert scale resulting in a total score of 72, with higher scores indicating a higher level of heart-focused anxiety. CAQ has shown reliability and validity among cardiac patients [25].

    Adherence was defined as the proportion of treated patients completing the prescribed amount of content within the treatment period [26]. More data on usage and user experience of the intervention were collected, and a detailed analysis of these is presented elsewhere [27].

    Statistical Analysis

    A statistical analysis plan prepared in line with the CONSORT (Consolidated Standards of Reporting Trials) 2010 statement was completed before the trial database was locked, and treatment allocation was disclosed. No interim analysis was performed. The study had enough patients (n>126) to detect a medium effect size (Cohen's d=0.5) with the power of 80 at alpha level .05.

    Descriptive statistics are presented as mean (SD) or count (%) by treatment group, unless otherwise specified.

    The main analysis was conducted according to the intention-to-treat (ITT) principle for all outcomes. Multiple linear modeling was used to analyze the treatment effect on outcomes. Treatment allocation was entered as an independent variable, and HADS-T at follow-up was entered as a dependent variable. To achieve increased precision, age, gender, and baseline HADS-T were entered as covariates. In case of a nonsignificant treatment effect from the main analysis, 2 exploratory analyses with the HADS subscales (HADS-A and HADS-D) as separate outcomes were conducted. For the HADS-A analysis, only patients scoring >7 on the HADS-A subscale at baseline were included, with the corresponding selection applied to the HADS-D analysis. Thus, it was possible for patients to be included in both analyses if they score >7 on both subscales at baseline.

    ITT analyses were preceded by multiple imputation via chained equations and predictive mean matching [28]. This was done because (1) there were 11.7% (28/239) with missing values in the main outcome, (2) we could not expect values missing completely at random, and (3) preplanned analyses included multiple outcomes. The imputation model included main effects and the following prespecified interactions: age*treatment and sex*treatment. Moreover, 100 imputed datasets were created. The linear model was thereafter fit to each of these datasets, and resulting effect estimates were pooled using Rubin rules [29]. Sensitivity analyses of HADS-T were conducted on observed data. Supplementary analyses of HADS-T were performed based on per protocol (PP) data from all patients who had completed at least one homework assignment. Secondary outcomes were analyzed using ITT only. We report effect estimates as pooled adjusted point estimates (beta) with 95% CI. Paired t tests were performed for all outcomes (baseline vs follow-up) to assess change over time. The relationship between number of completed homework assignments and changes in HADS-T over time was calculated with Spearman rank-order correlation. Statistical significance was set to 5% (2-tailed).

    Analyses were performed in R version 3.4.0 (R Foundation for Statistical Computing, Vienna, Austria) [30] using packages base, foreign, ggplot2, mice, miceadds, MKmisc, stats, tableone, and VIM, and IBM SPSS version 22 (IBM Corp, Armonk, NY).



    During the 40-month recruitment period, 3928 patients were screened for eligibility, with a total of 239 (6.08% (239/3928) of all screened) randomized. Of these, 10.9% (26/239) were included based on HADS-D only, 38.1% (91/239) based on HADS-A only, and 51.0% (122/239) based on both subscales. The main reasons for exclusion were the following: being unable/unwilling to use the internet or mobile phone, followed by scoring <8 on both HADS subscales and language difficulties. In total, 34.6% (1359/3928) declined participation or did not return the informed consent form. Follow-up assessment was completed by 88.3% (211/239) of all patients, with a significantly higher percentage of completers in the control group (94.3%, 115/122) compared with the treatment group (82.1%, 96/117; Pearson χ21=8.6, P=.003). See Figure 1 for a study flowchart.

    Patient Characteristics

    Baseline patient characteristics were similar in both groups (Table 2). On average, patients were 59.6 years of age (SD 8.49), 33.5% (80/239) were women, 41.8% (100/239) had university level of education, 60.3% (144/239) were employed, and 18.0% (43/239) were taking antidepressant and/or anxiolytic medication in both groups. The corresponding percentages after treatment was 19.6% (18/92; 25 missing values) in the treatment group and 15.6% (18/115; 7 missing values) in the control group (P=.37).

    Figure 1. Flowchart of patients through the U-CARE Heart trial. iCBT: Internet-based cognitive behavioral therapy; HADS-D: Hospital Anxiety and Depression Scale-Depression subscale; HADS-A: Hospital Anxiety and Depression Scale-Anxiety subscale.
    View this figure
    Table 2. Patient characteristics. Observed data (no imputations).
    View this table

    In total, 33.1% (79/239) were sedentary or reported low levels of exercise, 16.7% (40/239) had previous diabetes mellitus, and 13.4% (32/239) had a previous MI. At baseline, 25.7% (30/117) in the iCBT group and 22.9% (28/122) in the control group had regular contact with a counselor within TAU. The corresponding percentage at follow-up was 21.1% (19/90; 27 missing values) in the iCBT group and 27.2% (31/114; 8 missing values) in the control group (P=.33).

    Primary Outcomes

    There was no difference in HADS-T scores at baseline between the iCBT and the control group (t237=0.56, P=.85). There was a general reduction in HADS-T over time in the total study sample (mean delta=−5.1; t237=12.92, P<.001).

    The main analysis showed no effect of treatment on HADS-T at follow-up (beta=−0.47, 95% CI −1.95 to 1.00, P=.53). Furthermore, the main analysis showed that men scored lower on HADS-T compared with women at follow-up (beta=−2.04, 95% CI −3.60 to −0.47], P=.01), and there was a borderline significant reduction in HADS-T per unit increase in age (beta=−0.08, 95% CI −0.16 to 0.01, P=.09) at follow-up. There was no interaction between treatment and sex, or treatment and age, on HADS-T (P for both >0.19). Congruent with the main analysis, separate exploratory analyses showed no effect of treatment on either HADS-A or HADS-D subscales (Table 3).

    Results of the sensitivity analyses were consistent with the ITT analysis. Both the PP analysis (beta=−0.87, 95% CI −2.47 to 0.72, P=.28) and the analysis with observed data (beta=−0.55, 95% CI −2.04 to 0.93], P=.46) with HADS-T as the outcome yielded no effect of treatment (Table 3).

    Secondary Outcomes

    Additional multiple linear models showed no effect of treatment on the secondary outcomes MADRS-S, CAQ, or BADS-SF at follow-up (Table 3).

    Adverse Events

    Two patients in the iCBT group and 3 patients in the control group reported severe depression (MADRS-S>34) or suicidal ideation (MADRS-S item 9 >3) at follow-up.


    Treatment adherence was low, with 46.2% (54/117) of the iCBT group not completing the introductory module, 38.4% (45/117) completing the introductory module only, and 15.4% (18/117) completing additional modules (Figure 2). Furthermore, only 0.9% (1/117) adhered to the treatment [26] by completing the recommended number of 14 steps within the 14-week treatment period. The number of completed homework assignments was not associated with change in HADS-T at follow-up, rs=.07, P=.53.

    Table 3. Outcomes at baseline and follow-up, change scores, and treatment effects. Mean (SD) and change are calculated from observed data. Effect estimates (beta) are pooled adjusted coefficients for treatment (internet-based cognitive behavioral therapy, iCBT) versus control (treatment as usual) on follow-up outcomes adjusted for sex, age, and baseline levels of the respective outcomes after multiple imputation.
    View this table
    Figure 2. Proportion of patients completing different number of steps in the internet-based cognitive behavioral therapy.
    View this figure


    Principal Findings

    In this RCT, we evaluated the effectiveness of a therapist-guided, tailored iCBT treatment compared with TAU to reduce symptoms of depression and anxiety among recent MI patients. Both groups reported a decreased level of symptoms of depression and anxiety over time to a similar extent, with no difference between groups at follow-up. Adherence was low compared with other tailored iCBT interventions for depression and anxiety [26], indicating most patients allocated to iCBT received only a small treatment dose.

    Overall, 6.08% (239/3928) of the screened patients were randomized. The main reasons for exclusion were reported as being unable or unwilling to use internet or mobile phone, HADS score below the inclusion threshold (<8), and language difficulties. Furthermore, a substantial number of patients screened for eligibility declined to participate. Reasons for declining are not fully known, but might include low perceived need for help or a preference for other treatment alternatives. Low interest in iCBT treatment among cardiac patients has also been reported previously. The InterHerz study [31], which resembles the U-CARE Heart RCT, ended prematurely because of low recruitment rates (12 patients in 6 months; personal communication October 1, 2017 with Professor Nadine Messerli-Bürgy). Negative attitudes toward, and low intentions to use, internet-based psychological interventions have been reported previously in other populations [32,33]. Access to face-to-face counseling and psychotropic medicine is readily available and is of good quality in standard MI care in Sweden, with an estimated 95% of cardiac clinics in Sweden assessing and referring patients with mental health difficulties to appropriate care [34]. As such, a low interest in iCBT interventions among cardiac patients may be expected, which in turn may be a barrier, or at least a challenge, for implementation in routine care.

    Previous findings suggest iCBT as an effective treatment for comorbid symptoms of depression and anxiety in patients with somatic conditions [13], and effective psychological interventions for emotional distress related to coronary heart disease are characterized by CBT techniques [9]. Given this, the lack of effect of the iCBT intervention found in this study may have several explanations. Two factors might be low treatment adherence in the intervention group and a significant spontaneous improvement in the control group. Most iCBT studies with positive results are efficacy studies based on self-referral by people seeking help on the internet. In this study, we recruited patients within a routine care setting using screening methods. However, treatment adherence to iCBT interventions has been found to be lower in effectiveness studies in primary care samples compared with samples recruited from Web-based self-referral [35,36]. It is likely that patients actively seeking out and self-referring to iCBT are more prone to stay active in treatment compared with those who are screened and offered participation. Indeed, some of the patients in this study reported that their strongest reason for joining the study was to assist in research rather than seeking help for their depression or anxiety. In addition, reporting severe depressive symptoms was an exclusion criterion.

    Another important factor that may have influenced treatment adherence was related to iCBT characteristics. The treatment and U-CARE portal used to deliver it were developed in consultation with patients with personal experience of depression and anxiety post-MI. In spite of this effort, the content and design of the intervention might not have been adjusted enough to end users’ needs, for example, in terms of relevance and workload. Indeed, treatment burden and failure to tailor content adequately are associated with negative iCBT user experience [37]. Moreover, therapist support has been shown to significantly improve iCBT treatment adherence and effect [38]. However, the amount of support needed in different populations may vary, with some patient populations potentially benefitting from more extensive support. Indeed, extending iCBT support through additional weekly telephone calls has been found to improve treatment adherence [39]. As such, real-time therapist support via telephone might have helped patients engage with and adhere to treatment over time. Furthermore, some previous successful psychological interventions (with high adherence) for cardiac patients [40-42] have been group-based CBT with a process-oriented focus. It remains to be investigated in a randomized trial if process-oriented, group-based formats are necessary in psychological interventions for cardiac patients.

    Patient characteristics may affect treatment adherence. The mean age of patients in this study was >10 years lower than the average MI population, but higher compared with other iCBT studies of patients with depression and anxiety [35,43,44]. Older age is correlated with lower computer literacy [45]. It is possible that patients experiencing technological difficulties were less active in treatment. Furthermore, the level of education was somewhat lower compared with other iCBT studies (40% university level vs 50-60%) [35,43,44], a factor further associated with low adherence to psychological treatment [46].

    Both groups reported improved psychological symptoms over time, with regression to the mean potentially explaining this pattern. In addition, a substantial spontaneous improvement has been reported for MI patients in symptoms of both anxiety and depression over time [47]. Our patients were recruited about 10 weeks post-MI to avoid spontaneous recovery diluting any treatment effects. However, this recruitment strategy may have resulted in patients finding other ways to improve their psychological well-being. Moreover, more patients in the control group than in the iCBT group reported initiating a contact with a local counselor during the study period, but the difference was not significant.

    Strengths and Limitations

    This trial recruited patients from 25 hospitals in both rural and urban areas in Sweden. The content and design of the portal and the treatment were developed in consultation with patients with personal experience of emotional distress post-MI to increase acceptability, relevance, and usability. We prepared a detailed statistical analysis plan and prespecified adjustment by covariates to ensure a transparent analysis procedure [48]. We have provided detailed descriptions of the intervention and its delivery, in line with recent reporting guidelines [49], enabling comparison with other iCBT treatments targeting cardiac patients. Therapist support was provided by licensed psychologists, specialized in the CBT methodology. Despite all efforts to develop a user-friendly and relevant iCBT treatment, adherence to treatment was low. Given the obtained dose of treatment was low, the effect of the treatment might be difficult to evaluate. The PP analysis did not differ from the ITT analysis. However, our definition of PP may be criticized of being too liberal (completion of only 1 homework assignment). Moreover, HADS was developed as a screening measure and might not be sensitive enough to detect minor changes over time. However, none of the more sensitive secondary outcomes assessments indicated an effect. Diagnostic interviews might have been a more valid assessment of symptoms of depression and anxiety. Furthermore, the initial cut-off of >10 in any of the HADS subscales was lowered early in the study to >7 to increase recruitment rate. Patients reporting a low level of depression and anxiety have less room for improvement, resulting in a reduced likelihood of detecting a treatment effect [50]. This might also have resulted in inclusion of patients experiencing a low level of emotional distress, and consequently low perceived need for psychological help.

    Future Directions

    Effective and accessible psychological treatments are important, given symptoms of depression and anxiety are common post-MI. Despite the success of iCBT trials [13], using self-referral recruitment methods for patients with a range of comorbid physical and mental conditions, alongside calls for the widespread implementation of eHealth interventions for cardiac populations [10], this study questions the promise of iCBT for MI patients recruited at cardiac clinics. As such, future research should examine the potential differences in terms of iCBT acceptability between populations recruited via self-referral versus clinical settings. Furthermore, increased efforts are needed to better understand how to improve treatment adherence. Such efforts may include exploratory studies investigating factors related to treatment acceptability. In interviews with participants in this study, some challenges have been identified. These are described elsewhere [27]. Finally, our results support the notion that systematic development and feasibility testing, in close collaboration with potential end users, should be undertaken to improve treatment relevance and acceptability [51]. Although this study was preceded by both semistructured feasibility testing and an internal pilot study, this was apparently not sufficient.


    In a randomized trial, we evaluated the effects of a therapist-guided, tailored iCBT intervention for depression and anxiety versus TAU among recent MI. Both groups reported less emotional distress after treatment, but iCBT did not significantly reduce symptoms of depression or anxiety in comparison with TAU. This lack of difference in treatment outcome may be explained by low treatment adherence, with further investigation into reasons for poor treatment adherence warranted. This study suggests that further research is required into the acceptability and feasibility of iCBT for an MI population before wide-scale implementation of similar eHealth solutions for this patient group.


    This study is part of U-CARE, which is a Strategic Research environment funded by the Swedish Research Council (dnr 2009–1093). U-CARE Heart is also funded by the Swedish Heart and Lung Association (dnr E 148/11); the Uppsala-Örebro Regional Research Council (dnr 22 86 61); Swedish Research Council for Health, Working Life, and Welfare (dnr 2014–4947); and the Vårdal foundation (dnr 2014–0114). The authors would like to thank all patients who participated in this study. The authors would also like to thank all participating hospitals, collaborating nurses, and doctors who helped them in the recruitment process. The authors are also grateful to research assistants Malin Fridlund and Kata Bordas who helped out in recruiting and informing patients in the study. The authors thank Amanda Romppala for helping out administratively. The authors would also like to acknowledge Maria Bertilsson, Lars Lindhagen, and Ronnie Pingel at Uppsala University for statistical support.

    Authors' Contributions

    CH, EO, GB, LvE, and FN designed the study. JW, FN, EW, and EO analyzed the data. FN and EW drafted the manuscript. All authors critically revised and edited the draft and approved of the final version. JW, FN, EW, EO, and CH had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

    Conflicts of Interest

    None declared.

    Multimedia Appendix 1

    Sitemap of the Web-based portal.

    JPG File, 8MB

    Multimedia Appendix 2

    Screenshot of the U-CARE Heart portal.

    JPG File, 2MB

    Multimedia Appendix 3

    CONSORT E-HEALTH checklist (v 1.6.1).

    PDF File (Adobe PDF File), 852KB


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    BADS-SF: Behavioral Activation for Depression Scale-Short Form
    CAQ: Cardiac Anxiety Questionnaire
    CBT: cognitive behavioral therapy
    HADS: Hospital Anxiety and Depression Scale
    HADS-A: HADS-anxiety score
    HADS-D: HADS-depression score
    HADS-T: HADS-total score
    iCBT: internet-based cognitive behavioral therapy
    ITT: intention-to-treat
    MADRS-S: Montgomery-Asberg Depression Rating Scale-Self Rated
    MI: myocardial infarction
    PP: per protocol
    RCT: randomized controlled trial
    SMS: short message service
    TAU: treatment as usual

    Edited by G Eysenbach; submitted 22.12.17; peer-reviewed by A Conway, A Parks; comments to author 18.01.18; revised version received 02.02.18; accepted 08.02.18; published 08.03.18

    ©Fredrika Norlund, Emma Wallin, Erik Martin Gustaf Olsson, John Wallert, Gunilla Burell, Louise von Essen, Claes Held. Originally published in the Journal of Medical Internet Research (, 08.03.2018.

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