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Maintaining a sufficiently high systolic blood pressure is vital for free flap perfusion after microsurgical breast reconstruction. However, many women undergoing microsurgical breast reconstruction have low systolic blood pressure postoperatively. Often, intravenous volume administration or vasopressors are needed to maintain systolic blood pressure above 100 mm Hg.
JMIR Res Protoc 2023;12:e38487
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Preclinical and clinical studies have explored normothermic (35-37°C), sub-normothermic (20-25°C), and hypothermic (4-10°C) machine perfusion with (hypothermic oxygenated perfusion [HOPE]) or without (hypothermic machine perfusion) oxygen [3,7]. Dynamic perfusion improves the quality of high-risk grafts, removes waste products, and provides metabolic substrates for ATP and glutathione generation, which protects against reactive oxygen species–related damage [7].
JMIR Res Protoc 2020;9(3):e13922
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In addition, we controlled for participant’s age, body mass index (BMI; kg/m2), and other environmental factors that could affect a woman’s heart rate, respiratory rate, HRV, WST, or skin perfusion.
In total, 237 women participated in our study.
J Med Internet Res 2019;21(4):e13404
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