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Digital Therapeutics in China: Comprehensive Review
J Med Internet Res 2025;27:e70955
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Chen et al [21] reported a higher alert rate of 3.12% and a lower acceptance rate of 48.88% over 2 years, with only 28.08% of accepted alerts leading to actual prescription changes. This lower modification rate may reflect the broader definition of acceptance used in their study, which included mere acknowledgment of alerts, as well as the absence of embedded diagnostic recommendations that directly address diagnostic omissions.
J Med Internet Res 2025;27:e70731
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Specifically, the sample size was calculated via the Hsu (with best) multiple comparison test by the Power Analysis and Sample Size 14, with α=.05, power=0.80, the MDs between different groups=6.139, and the common SD within a group was assumed to be 7.16, resulting in a total sample size of 138 (46 in each group). Accounting for a 10% dropout rate, the final sample size was planned to be 153 participants.
J Med Internet Res 2025;27:e71741
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