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Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review

Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review

Exclusion criteria The studies involved self-reported diagnosis or classification solely based on AD risk factors (eg, Apolipoprotein E ε4 allele and family history of AD), or the investigated population only included individuals with dementia.

Rosanne L van den Berg, Sophie M van der Landen, Matthijs J Keijzer, Aniek M van Gils, Maureen van Dam, Kirsten A Ziesemer, Roos J Jutten, John E Harrison, Casper de Boer, Wiesje M van der Flier, Sietske AM Sikkes

J Med Internet Res 2025;27:e65297

Testing the Impact of Intensive, Longitudinal Sampling on Assessments of Statistical Power and Effect Size Within a Heterogeneous Human Population: Natural Experiment Using Change in Heart Rate on Weekends as a Surrogate Intervention

Testing the Impact of Intensive, Longitudinal Sampling on Assessments of Statistical Power and Effect Size Within a Heterogeneous Human Population: Natural Experiment Using Change in Heart Rate on Weekends as a Surrogate Intervention

(E) Time-delay embedding of an individual with greater HR on weekdays. The median pairs of samples required to find a statistically significant difference between weekend night and weekday night HR at P A subset of 8798, 9964, and 12,018 individuals from the dataset of 46,217 individuals did not reach significance in any of the 100 runs of within-individual, within-individual temporal, or within-individual sequential sampling, respectively.

Severine Soltani, Varun K Viswanath, Patrick Kasl, Wendy Hartogensis, Stephan Dilchert, Frederick M Hecht, Ashley E Mason, Benjamin L Smarr

J Med Internet Res 2025;27:e60284