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Currently submitted to: Journal of Medical Internet Research

Date Submitted: Jul 27, 2020
Open Peer Review Period: Jul 27, 2020 - Sep 21, 2020
(currently open for review)

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Short Paper: Risk Factors for Long-Term Persistent Symptoms in COVID-19 in an Outpatient Cohort

  • James O'Keefe; 
  • Ghazala A Datoo O’Keefe; 
  • Anthony Mufarreh; 



Symptom descriptions in outpatients with COVID-19 are limited to cross-sectional surveys and longitudinal follow-up of long term symptoms has not been reported. Symptom duration is important for patient and provider knowledge in managing outpatient COVID-19.


Describe the presence of symptoms at long term follow-up of patients managed in an outpatient telemedicine program for acute COVID-19.


Chart review of clinical notes for acute COVID-19 and long term follow-up calls. Descriptive analysis were conducted using Wilcoxon rank-sum for continuous variables and chi-square or Fisher’s Exact as appropriate for categorical variables.


Minor symptoms were reported by 55 patients (34.8%) and 7 (4.4%) reported major ongoing symptoms at follow-up call. Factors associated with prolonged symptoms include older age, provider reported higher symptom severity at intake visit, and BMI >30. Symptoms which persisted include shortness of breath on exertion, wheeze, nausea, and joint pain.


Persistence of symptoms after acute COVID-19 in outpatients is common. Risk factors may help predict which patients are more likely to have prolonged symptoms.


Please cite as:

O'Keefe J, O’Keefe GAD, Mufarreh A

Short Paper: Risk Factors for Long-Term Persistent Symptoms in COVID-19 in an Outpatient Cohort

JMIR Preprints. 27/07/2020:22943

DOI: 10.2196/preprints.22943


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