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Currently submitted to: Journal of Medical Internet Research

Date Submitted: Sep 20, 2019
Open Peer Review Period: Sep 21, 2019 - Oct 16, 2019
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Diagnosis Performance of Computer-Aided Detection on Breast Lesions Less and More Than 2cm

  • Liang Yongping; 
  • Ping Zhou; 
  • Zhang Juan; 
  • Zhao Yongfeng; 
  • Wengang Liu; 
  • Yifan Shi; 



Computer-aided Detection (CAD) is increasingly being used as an aid tool by radiologists on breast lesion diagnosis. Previous studies demonstrated that CAD can improve the diagnosis performance of radiologist. However, the optimal use of CAD in breast lesions less and more than 2cm has not been mentioned.


To compare the performance of different radiologists by using CAD to detect breast cancer in size less and more than 2cm.


We prospectively enrolled 261 consecutive patients (mean age, 43years; age range, 17–70 years), 398 lesions (148 more than 2cm, 79 with malignant, 69 with benign; 250 less or equal to 2cm, 71 with malignant, 179 with benign), with breast mass as prominent symptom. One novice radiologist with 1 year of US experience and one experienced radiologist with 5 years of US experience were assigned to read US images without CAD, and at a second reading combined with CAD. Diagnostic performances were compared by using analysis of variance.


For novice reader, the area under the receiver operating characteristic curve improved from 0.743 (95% confidence interval [CI]: 0.669, 0.817) at without-CAD mode to 0.884 (95% CI: 0.834, 0.933; P<.001) at the combined-CAD mode in lesions less or equal to 2cm, for experienced reader those were from 0.838(95% CI :0.773,0.903) to 0.902(95% CI :0.862,0.942; P=.002). Those were from 0.806 to 0.797(novice reader) and 0.895 to 0.822 (experienced reader) in lesions more than 2cm. The sensitivity of novice and experienced reader in lesions less than 2cm improved from 61.97% and 73.23% at without-CAD mode to 90.14% and 97.18% at combined-CAD mode, respectively.


Computer-aided detection (CAD) was helpful for novice and experienced reader to improve cancer detection at breast US in lesions less than 2cm. CAD was more sensitive for both novice and experienced reader. Clinical Trial: ChiCTR1800019649


Please cite as:

Yongping L, Zhou P, Juan Z, Yongfeng Z, Liu W, Shi Y

Diagnosis Performance of Computer-Aided Detection on Breast Lesions Less and More Than 2cm

JMIR Preprints. 20/09/2019:16334

DOI: 10.2196/preprints.16334


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