Human history has been marked by technological innovation. Generative AI (GenAI), including large language models (LLMs), has resulted in a technological revolution [1]. While LLMs have tremendous technological potential, we, as a society, must be cognizant of the enormous potential social costs of LLMs without deliberate inclusiveness and safeguards. Failure to include the entire population, including medically underserved populations, in the AI technological revolution risks increased wage disparities, reduced productivity, and lower government revenue. Medically underserved populations include geriatric individuals, those with learning disabilities, low-income individuals, homeless individuals, and those with substance use disorder. The effects of the digital divide, conventionally referred to as persistent health care disparities in digital health care access [2], are most acutely felt in these populations. The disparities can lead to exclusion from the use of new technologies, such as AI, especially among underserved populations.

For technological innovations to be acceptable to and accessible to the public, we must consider both social and technical aspects. Examples of sociotechnical innovations in health care include electronic health records (EHRs), communication applications, clinical decision support, and telehealth models. The social aspect of these health care tools involves user workflows and organizational policies surrounding their use, which are influenced by individuals’ level of digital literacy.

To address the social aspects of the deployment of digital technologies, we adapted the CREATE framework proposed by Talal et al [3]. Our adaptation reflects CREATE as (C=culture, R=respect, E=education, A=advancement, T=trust, E=expertise). The CREATE framework outlines the processes to engage stakeholders in the acceptability, feasibility, and usability of digital technologies in various communities. Implementation of new technologies must consider how individuals will engage with the technology. An engagement framework, such as CREATE, is necessary when considering people with opioid use disorder (OUD), a patient population that is typically stigmatized, medically underserved, and difficult to reach [4]. People with OUD enroll in opioid treatment programs (OTPs) for medical and behavioral treatment of addiction recovery. The recovery journey can be difficult, lengthy, and requires dedicated OTP staff involvement to comprehensively manage patients’ progress. New York State was a pioneer in the treatment of OUD [5]. As a result, its procedures for treatment of OUD have been honed over decades. Although in this paper we refer to New York State–based OUD treatment procedures as a use case, substance use disorder treatment requires the collection of extensive clinical information. The lessons learned are transferable to the treatment of substance use disorder and health care more broadly.

In the treatment of OUD, one of the fundamental instruments that inform the creation of treatment plans in OTPs is the psychosocial evaluation form completed within 30 days of admission. The psychosocial form is a comprehensive and detailed history of critical life areas and includes, among other aspects, past and present drug and alcohol use history, prior treatment history, family, legal, and trauma history, and physical and mental health information. The collection of these data and the construction of a patient-centered treatment plan are one of the most important and time-consuming processes of a counselor’s responsibilities. Enhancing the value of the psychosocial instrument by implementing new technologies in the workflows of OTPs has the potential to streamline data collection and mitigate inefficiencies. It might ensure that patient information is collected in a systematic, reproducible, and standardized manner, resulting in high-quality data for use in the development of treatment plans.

The pursuit of high-quality, data-driven evidence enhanced by information generated from complementary sources, such as high-quality qualitative studies, allows individuals to make better choices about health and health care [6]. In the OTP setting, evidence is translated into trust. Before LLM-based systems can be trusted with personal health information, an important objective is to ensure that all stakeholders agree that such systems are error-free, rigorous, and reproducibly generate data-driven evidence. These systems can also be of assistance when collecting data necessary to generate evidence that ultimately leads to improved health outcomes and/or better health care delivery.

The evaluation of technology incorporated into OTP workflows consists of assessing the safety and process compliance of the tools as well as evaluating their effectiveness. Therefore, before embedding LLM-based systems into OTP workflows, a safety evaluation is necessary to avoid and/or correct errors and ensure compliance with institutional metrics and standards (process compliance) [7]. An additional level of evaluation that is required is an assessment of effectiveness. This means that unambiguous and reproducible evidence is obtained that demonstrates improved outcomes. The goal of the evaluation process is a clear demonstration that the embedded technology has a positive impact on the health of individuals and/or the health care delivery process.

A risk-benefit assessment is important to compare potential risks against beneficial outcomes. Identified risks associated with the use of LLM-based systems in OTP workflows include potential biases, hallucinations (ie, confabulation by the LLM-based system), and loss of privacy, security, and confidentiality. Benefits include the potential to streamline administrative tasks, resulting in considerable time savings, and improve patient assessment and education. Some of these tasks tolerate the incurrence of small errors that can be corrected by the human interfacing with these systems, while others, such as patient assessment, must be error-free. The development of quantitative risk-benefit measures ensures informed decision-making. Regulatory processes need to ensure the initial safety of the AI tools with continuous monitoring to guarantee quality and adaptability to current circumstances.

The paper explores important social considerations and evidence generation needs when attempting to integrate LLMs into clinical spaces for health care delivery. Recent investigation within the health care arena has focused on LLMs promoting increased patient-centered health care [7-9], partially through the expression of empathy [9]. Therefore, the primary aims of this viewpoint are: (1) to elucidate the strengths and limitations of using AI technologies, such as LLM-based tools, in health care delivery workflows (this aim is articulated in the remainder of the paper). To provide recommendations for potential adoption in clinical scenarios with an emphasis on underserved populations to facilitate patient-centeredness (see sections “What are Recommendations to Improve Applicability and Trust of LLMs to Vulnerable Populations?” and “Considerations for Deployment of AI Systems for Underserved Populations”). To discuss the adoption of these systems through the lens of Diffusion of Innovations (DOI) theory [8] (see “LLMs as Socio-Technical Systems: Diffusion of Innovation”). (2) To discuss the evaluation of LLM-based systems from multiple aspects (see “Evaluation of LLM-based Systems”). (3) To discuss the impact of data quality on AI outputs and evidence generated from these systems; and to discuss the impact of using the generated evidence on health care decision-making (see sections “Use of LLM-based Systems for High-Quality Data Acquisition and Improving Clinical Outcomes,” and “Evidence Generation and Risk Assessment in OTPs”). (4) To present and discuss an extension of the traditional hierarchy of evidence model to include the risks associated with deploying AI-based systems at various stages of data collection, exemplified in the case of OTPs (“Evidence Generation and Risk Assessment in OTPs”). (5) To propose the CREATE framework as a facilitator of the participation of all relevant stakeholders in the development and deployment of AI systems in health care workflows and present several considerations to gain acceptance of LLM-based systems by necessary stakeholders to maximize the likelihood of deployment and use (“Engagement Approaches: CREATE Framework”).

According to the US Congress [9], “Large language models (LLMs) are AI systems that aim to model language, sometimes using millions or billions of parameters.” On a more technical level, LLMs are complex neural networks using the transformer architecture and the attention mechanism proposed in [10]. The word “large” usually refers to the large number of parameters (often billions of parameters) used in training the neural network model to process the language. LLMs require considerable computational resources to be trained. LLMs form the core of LLM-based systems designed to provide various kinds of functionality such as machine translation, summarization, and conversational systems. Multimedia Appendix 1 presents a brief history of natural language processing (NLP) along with a timeline of evolution of the field of NLP (Figure S1 in Multimedia Appendix 1), and Multimedia Appendix 2 briefly discusses details associated with LLMs and applications in health care [11-14].

With newer applications of LLMs emerging every day, it is imperative to be informed of the limitations of these systems as well. Several technical and social challenges are associated with deploying any LLM-based system and their use context. The technical challenges of such systems are discussed in detail in this article from the perspective of accuracy of the generated output and usability of such systems, which are evaluated primarily on output quality. Unfortunately, their usability is often overlooked in outcome assessment. We emphasize that usability of such systems, including their safety and reliability, is an important consideration because in clinical settings such systems do not exist in isolation but rather as integrated socio-technical systems (STSs) to facilitate patient care (see section “Evaluation of LLM-based Systems”).

Deploying LLM-based tools in health care might also lead to potential social challenges. The authors in [15] describe various risks associated with using LLM-based tools in public health. These risks are even more prominent when serving an underserved population. Given that OTPs function as destigmatizing safe spaces, the implications of introducing LLM-based tools in this environment must be carefully evaluated. The key risks include erecting additional barriers to help-seeking, degradation of patient-provider trust and support systems, missed opportunities to proactively introduce help, and dehumanization and impersonality in care, among others. We provide detailed descriptions of various activities in which LLM-based systems can be used in OTPs while keeping in mind these risks and ensuring that patient-centeredness is not lost.

STS is defined as “a complex system that includes both technical and social elements, such as people, technologies, rules, and regulations, that work together to create work processes and products” [16]. The definition of STS immediately points to the fact that LLM-based tools in the context of health care are essentially STSs. The conceptual model for health information technology (HIT) introduced by Sittig and Singh [17] is appropriate for this context. The 8 dimensions of this model are computing infrastructure, clinical content (clinical “data-information-knowledge continuum”), human-computer interface, people, workflow and communication, internal organizational policies, procedures and culture, and external rules and regulations. This conceptual model is appropriate for an LLM-based system as well. In the context of an LLM-based system, the technical component is represented by the computing infrastructure, the model architecture, datasets, and the associated infrastructure required to build such systems. The social component includes system developers, patients, the institution where such a system is deployed, the clinical staff, as well as ethics and any associated regulations. Failure to consider the interdependencies between the different components has the potential to result in the pitfalls described below [18].

The effects of getting stuck in any of these traps in a health care setting are consequential for treatment outcomes and patient health. The successful integration of LLM-based systems into existing settings and workflows depends on understanding the abilities and limitations of the components of the STS, the LLM-based system itself, as well as the social context in which it is deployed. The CREATE framework described later in the paper (Section “Engagement Approaches: CREATE Framework”) emphasizes the social considerations needed to increase the likelihood of full integration of LLM-based systems into OTPs.

To avoid the pitfalls discussed previously, understanding the technical aspects of LLM-based systems alone is insufficient; one must also consider the social system context. We offer insights on the adoption of LLM-based tools in OTPs through the lens of DOI theory. DOI theory has been widely applied to describe the important considerations when introducing any new technology. The adoption of new technology within the health care context is always a multistakeholder approach, which extends beyond the potential technical advantages, considering multiple stakeholders and defining their role in the adoption process. While DOI describes how an intervention spreads within a setting, CREATE serves as a framework for consideration of the social aspects of intervention adoption. Of particular interest in the OTP setting is its resource-scarce nature and the underserved population it serves, leading to additional trade-off considerations between purported advantages and potential loss of patient-centeredness and straining limited resources. We have described in detail the elements and characteristics of innovation (LLM-based tools) in the context of OTPs in Tables 1 and 2. The DOI theory highlights that the adoption of LLM-based tools is inherently an interplay between the social and the technical components. The aspects of trust and risk associated with such STS are discussed in a later section in this paper.

To guide engagement of stakeholders with LLM-based systems, we extended the CREATE framework developed in [3] (Figure 1). The CREATE framework outlines the processes to address the social aspects of technological integration into a community. Elucidating clinical workflows for patient care facilitates understanding of the OTP culture. Respect for OTP staff and patients is manifested by incentives, avoiding stigmatizing language, and through co-leadership decisions. Education about technology, addressing anxiety through knowledge, and co-learning between patients and staff promote a respectful attitude toward technology. Education also promotes technological advancement through invention and the application of new tools. Promoting trust among patients and staff in LLM-based tools is required for deployment. LLM use is enhanced by ensuring privacy, confidentiality, and security of the technology. Successful LLM deployment and use require expertise in multiple disciplines, and the CREATE framework can address the social aspects of technological deployment in underserved communities. Considerations for evaluation matrices of each of the 6 CREATE framework domains are illustrated in Table S1 in Multimedia Appendix 3. Consideration of the CREATE framework domains, as judged against conventional implementation frameworks, is listed in Table S2 in Multimedia Appendix 3.

As a major funder of comparative effectiveness research, the Patient-Centered Outcomes Research Institute (PCORI) has developed 6 foundational aspects of research partnerships. Table 3 illustrates how the CREATE framework aligns with PCORI’s 6 foundational expectations for partnerships in research [25].

LLM-based systems have shown good performance in several use cases. Some examples include responding to prevention questions from patients in cardiology [26], hip replacement [27], and radiology report findings [28]. Novel experiments integrating LLMs as clinical decision support tools are needed to evaluate their effect on outcomes, productivity, and patient satisfaction [29]. Existing literature has evaluated LLMs’ abilities to respond to portal patient messages [30], generate discharge summaries [31], generate structured templates for radiology [28], and support the management of breast cancer tumor boards [32]. Furthermore, LLM-based systems have been successfully implemented in diagnostic image processing and clinical decision support [33]. They play a role in social media monitoring and track trends in OUD that correlate with real-time morbidity and mortality reporting [34]. AI can also be useful in the development of medical guidelines [35] and in the construction of systematic reviews [36].

Part of the challenge of integrating LLM-based systems into clinical workflows is that minor changes in the inputs produce unpredictable outputs [29]. Furthermore, the technology is evolving rapidly, and as it becomes more widespread, a potential issue is overreliance on its output while negating its limitations and biases. As an alternative to AI in the application to health care, the American College of Physicians recommends the term “augmented intelligence” when referring to the role of AI in clinical decision-making. The objective is to promote the concept that human intelligence continues to be central to the clinical decision-making process even when integrating AI, and that AI is a tool to assist clinicians [37,38].

LLM-based systems can be used to address the digital divide. We can use knowledge generation and educational functionalities to enhance digital literacy among patients. LLM-based systems can also be used to combine data on a particular patient within an electronic medical record and to support prior authorizations for medications. In these situations, it would be helpful to have the human in the loop [39] to be able to verify information. Human-in-the-loop (HITL) refers to the integration of an expert into a machine learning or AI workflow to improve the quality of the system’s intended outcomes. In the health care context, expert knowledge and experience are essential, requiring the augmentation of skilled experts, rather than subordinating their skills. Similar to HITL, the terminology “Doctor-in-the-loop” has also been coined [40]. Several works [41] have explored the incorporation of expert knowledge to improve the trustworthiness of AI system–based workflows. In health care, transparency is one of the key requirements for LLM-based systems, which can then support the HITL framework to increase trust in the system [42].

Appropriate LLM-based systems might promote patient-centeredness. LLMs can de-stigmatize language and can suggest alternative language choices. The goal is to promote more empathetic language among health care providers and in public health messaging [43]. LLMs can potentially play an important role in patient and staff education. They can develop culturally and linguistically relevant educational materials, potentially improving patient understanding, medication adherence, and trust in providers [44]. LLMs, in combination with structured EHR data, can develop models that predict treatment attrition, enabling targeted interventions [45]. They may have a potential role in OTP staff training and simulation. LLM-driven virtual patient agents can simulate realistic patient-provider interactions, offering a controlled and ethical environment for training OTP staff in therapeutic dialogue strategies for addiction recovery [46]. The goal is to promote LLM-directed patient-centered messaging and education.

As presently performed, the generation of a client’s treatment plan is a relatively lengthy and laborious process as described in Figure 2.1. When a patient is admitted to an OTP in New York State, the first point of contact is an initial phone screen that gathers basic demographic information and assesses patient eligibility for treatment of OUD. The next step is an admission eligibility assessment by a physician or advanced practice provider. Once the patient is admitted to the OTP, the clinician completes an admission form that includes more extensive information on drug use, residential situation, family history, and information on employment and education. The patient is then assigned to a primary counselor within 24 hours who schedules an initial session to obtain the psychosocial form, which must be completed within 30 days of admission (email, personal communication, Office of Addiction Services and Supports [OASAS], New York, March 31, 2026).

Once the psychosocial form has been completed, data are aggregated from the 4 sources illustrated in Figure 2.1 to develop an assessment summary. Upon completion of the assessment summary, the multidisciplinary team meets to develop a treatment plan. The next step is to present and discuss the treatment plan with the patient. Following the discussion with the patient, an initial 90-day treatment course is implemented.

There are several steps at which LLM-based systems can be involved during the creation and implementation of the treatment plan, as illustrated in Figure 2.2. LLM-based systems can be integrated into the data collection stage to facilitate the collection of higher-quality data to inform patient care. Additionally, LLM-based systems can be used to aggregate the collected data from different sources with varied structures to develop treatment plans that consider the unique circumstances of a patient, prioritizing specific aspects of the treatment and supporting ongoing addiction management. Finally, such systems can be used to aid treatment adherence, which is known to be a difficult challenge in the case of addiction recovery. Important considerations for integration of LLM-based systems in different areas of the workflow are also presented.

Furthermore, an empathetic LLM-based system could potentially administer the psychosocial assessment and develop its clinical summary. LLMs could also develop the assessment summary through the aggregation of data from multiple sources. In terms of developing a treatment plan, LLMs could prioritize the most important aspects and assess their severity. The multidisciplinary team could ultimately assess and verify the output of the LLM-based system, similar to the HITL approach described previously. Finally, the LLM-based system can support patient adherence to the 90-day treatment plan.

In the previous section, we have illustrated how LLM-based systems can be used for developing individualized treatment plans for patients with OUD. One of the major components of developing these treatment plans is collecting data using high-quality instruments. The goal of using LLM-based systems is to generate individualized treatment plans dedicated to specific patient types and reduce associated errors.

From a higher level of abstraction, an important research interest is how LLM-based systems or LLMs can be used for processing vast amounts of data to inform better patient care. OTPs collect massive amounts of textual data consisting of clinical narratives, patient-reported information, and other records. LLMs can be used for converting free text into structured datasets, performing data extraction, and other data processing tasks. These procedures broadly aid in dataset generation that informs care about specific populations.

Table 4 lists the various proposed applications of LLM-based systems along with associated evidence of their implementation in health care situations and briefly indicates whether HITL might be required for oversight.

Prior to the integration of any LLM-based systems, or rather any system in the health care context, understanding associated challenges and evaluating risks vs benefits is of utmost importance. These challenges impact the reliability of generated output, and consequently the quality of evidence and hence need to be addressed to ensure safety and trust. A summary of challenges in the health care context is given in Table 5.

The challenges discussed in this section necessitate a robust evaluation strategy considering multiple aspects described in the next section.

Given the potential benefits and risks of implementing LLM-based systems in health care programs, decisions about their adoption must be guided by a balanced assessment of both dimensions. Beyond the general concerns discussed in prior sections, levels of risk of LLM integration in a health care program should be assessed critically based on the function of the model and the type of input data. For a better visualization of the benefits and risks aspects of LLM-based systems, the pyramid model presented in Figure 3 illustrates the central rationale for LLM integration in OTPs. The deeper the integration of an LLM model with more clinically dedicated tasks and the richer the data sources, the higher the level of evidence obtained, and consequently, the higher the risk associated with LLM-based systems (Figure 3).

Telephone screening is the foundation of the pyramid, which typically occurs before formal OTP admission. This interaction involves acquiring basic demographic information and assessing patient eligibility for OUD treatment. The LLM-based system functions (eg, summarizing call transcripts, extracting key variables, and generating reminders for follow-up) work with the lowest level of input. As a result, errors from LLM-based systems at this stage rarely affect immediate clinical decisions, so the risk is minimal. Thus, we obtain the lowest level of evidence generation (–2) in the pyramid model. During OTP admission, programs collect patient information on psychosocial forms. The pyramid illustrates that, at each subsequent level of risk, the complexity of clinical information increases. Simultaneously, the risks and consequences such as a breach become increasingly costly.

Policy frameworks for AI are currently in a state of rapid and continuous change. Regulations and laws written to govern the use of AI neither address the challenges nor the opportunities associated with such systems [77]. In July 2024, the European Union adopted Regulation (EU) 2024/1689, commonly known as the EU Artificial Intelligence Act, thereby establishing the first AI regulation as a comprehensive framework to regulate AI systems [78]. The act includes a risk-based regulatory framework that differentiates obligations for AI developers and deployers according to the level of risk posed by specific systems [78-80], categorizing the risk into unacceptable risk, high risk, transparency risk, and minimal risk. For further information see [78].

In the United States, there are no federal laws dedicated solely to AI. The existing framework relies on a patchwork of device, data privacy (such as the Health Insurance Portability and Accountability Act [HIPAA]), and liability laws. However, the regulatory landscape for AI in the United States is currently undergoing a period of rapid and significant transition [81, 82]. In December 2025, an executive order was issued to foster a more unified national environment for AI by aligning federal and state policies to ensure a supportive regulatory framework for AI innovation [83]. Over a dozen states have enacted laws designed to ensure safeguards and guardrails for the use of AI. For example, New York State’s RAISE Act outlines key AI risks including cybersecurity threats, system failures, criminal contact, weaponization, and critical harm resulting in death or serious injury. For more information, please see the RAISE Act (S.53/A.6453) [84]. The act also has reporting requirements for managing risks including safety protocols, third-party reporting requirements, and auditing procedures. California has also enacted a similar law “Transparency in Frontier Artificial Intelligence Act (SB53)” that is designed to enhance online safety and install guardrails on the development of frontier AI models. Other governments are rapidly developing new laws or regulations or adopting targeted restrictions [77].

Companies are expected to release successively more powerful and capable LLM-based systems in the coming months, which may introduce new benefits but also new regulatory challenges. While these laws and regulations provide general guidelines for the use of AI systems, one must keep them in mind when developing LLM-based systems targeted at underserved populations.

While there are many reporting guidelines for the use of AI tools in medicine [85] and many relevant consensus statements [86], it is imperative that the adoption of AI systems is based on robust, reproducible evidence obtained via scientifically sound evaluation processes.

When introducing new technologies to people with OUD, recommendations to build patient-doctor trust include stigma minimization, promotion of empathy in the patient-provider relationship, and engaging community organizations to build bridges with health care providers and institutions. With regard to LLMs, to guard against bias and hallucinations, rigorous benchmarks must evaluate LLM-based systems using medical data and tasks, so that reproducibility can be evaluated and developmental progress tracked [29]. These systems must also be evaluated against, for example, frameworks that have emphasized ethical aspects, such as respecting human values and being inclusive [87] and promoting transparency in AI use [88,89]. Humans should have ultimate oversight to ensure trustworthy AI outputs.

The unknown nature of some AI models, as the fundamental “black box” design of contemporary LLMs [90], can promote distrust among providers [33]. In the development of these tools, clinical safety, effectiveness, and health equity must be top priorities. A continuous improvement feedback mechanism should be used to promote improvements in AI tools and to report adverse events resulting from the use of AI. LLM-based systems may be able to assess for potential biases and inequity in OUD treatment plans across different patient demographics (race, ethnicity, and sex). These systems may also have a potential future role in promoting equitable OUD management decisions [91].

Policies toward LLM-based system implementation and deployment in health care settings that care for underserved populations have several considerations (Table 6). Consideration of the domains of engagement as well as the different stakeholders is very important. Particularly important are governmental agencies that can encourage adoption of LLMs through financial incentives or reimbursement for their use. Correspondingly, they also have a role in ensuring security, confidentiality, and privacy of LLM-based systems.

Technological innovation is a facet of the human condition and has occurred ever since the evolution of humanity. Consideration of how to increase trust and respect in technology is vital, universal, and extremely important, especially when revolutionary technologies, such as AI, are considered.

In this paper, we discuss the adoption of new technology through the lens of DOI theory and extend the CREATE engagement framework to facilitate the implementation of LLM-based systems into OTP workflows. Future research should seek to evaluate the effectiveness of the CREATE engagement framework as related to LLM deployment. Another area for future investigation is evaluation of implementation outcomes, as would conventionally be assessed using standard implementation frameworks, such as Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) [92] or Consolidated Framework for Implementation Research (CFIR) [93]. Evaluation matrices for each of the 6 components of the CREATE framework are listed in the Multimedia Appendix 3 and could serve to highlight specific areas for future research inquiry.

Advances in foundation models, such as multimodal processing, increased planning capabilities, and subsequently the development of autonomous LLM agents with the ability to interact with a wide array of tools, emphasize the need for the CREATE framework even further. “Advancement” drives the adoption of these newer innovations into various aspects of patient care, while “trust” ensures that it is done under rigorous oversight by giving patient safety and confidentiality the highest priority. At the same time, these advances have led to the rise of new challenges, underscoring that “expertise” continues to incorporate the needed skills as new innovations are introduced in LLM-based systems. These developments highlight the indispensable role of human experts in ensuring that LLM-based systems are safely and effectively integrated into clinical workflows.

Olawade et al [94] present a narrative review of HITL AI in health care and discuss associated implementation challenges and future research directions. Along with HITL, further research is needed on human-computer interaction involving AI tools. These tools must be developed in a manner that facilitates the collaboration between humans and AI to build trust, ensure usability, and promote adoption [95]. Additionally, an important research area is understanding the economic implications of deploying these tools in health care [96].

The multifaceted pyramid of data, evidence generation, and risk associated with LLM-based systems illustrates the relationships between the different faces and associated levels of evidence generation. The information present in the collected data is fundamental for high-quality evidence generation. The progression among the different levels of the data face of the pyramid can be interpreted as higher levels in the data hierarchy indicate higher information content, which, subsequently, increases the risk associated with the AI system deployment, while simultaneously increasing the quality of evidence associated with the health care recommendations provided to patients. How to formalize these relationships and their interaction with the CREATE framework remains the topic of a different paper.

While the science behind AI is relatively new, issues to resolve remain and must be satisfactorily addressed to ensure the public’s acceptability of the technology. Recently enacted legislation at the state level to provide guardrails for the use of AI is a step in the right direction, although additional topics remain when considering targeting underserved populations. Multidisciplinary perspectives represented by linguistics, computer science, statistical sciences, and medicine are needed to optimize the health care application of LLMs.