<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v28i1e85917</article-id><article-id pub-id-type="doi">10.2196/85917</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Application of Digital Health Technologies in Cardiac Rehabilitation for Patients With Coronary Heart Disease: Scoping Review</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Zhu</surname><given-names>Xinyu</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Liu</surname><given-names>Lei</given-names></name><degrees>PhD, MD, Prof Dr</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Wang</surname><given-names>Yingjie</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Li</surname><given-names>Hongyuan</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Zang</surname><given-names>Min</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Wang</surname><given-names>Jiayu</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Tian</surname><given-names>Yu</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Li</surname><given-names>Zihan</given-names></name><degrees>MSN</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><institution>Liaoning University of Traditional Chinese Medicine</institution><addr-line>Shenyang</addr-line><country>China</country></aff><aff id="aff2"><institution>School of Nursing, Liaoning University of Traditional Chinese Medicine</institution><addr-line>79 Chongshan Road, Beita Street</addr-line><addr-line>Shenyang</addr-line><country>China</country></aff><aff id="aff3"><institution>Department of Nursing, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine</institution><addr-line>Shenyang</addr-line><country>China</country></aff><aff id="aff4"><institution>Department of Nursing, Dalian Friendship Hospital</institution><addr-line>Dalian</addr-line><country>China</country></aff><aff id="aff5"><institution>Liaoning Cancer Hospital &#x0026; Institute</institution><addr-line>Shenyang</addr-line><country>China</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Brini</surname><given-names>Stefano</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Kitagaki</surname><given-names>Kazufumi</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Yang</surname><given-names>Zhen</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Lei Liu, PhD, MD, Prof Dr, School of Nursing, Liaoning University of Traditional Chinese Medicine, 79 Chongshan Road, Beita Street, Shenyang, China, 86 17824909908; <email>liulei0428@sina.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>29</day><month>4</month><year>2026</year></pub-date><volume>28</volume><elocation-id>e85917</elocation-id><history><date date-type="received"><day>15</day><month>10</month><year>2025</year></date><date date-type="rev-recd"><day>12</day><month>03</month><year>2026</year></date><date date-type="accepted"><day>12</day><month>03</month><year>2026</year></date></history><copyright-statement>&#x00A9; Xinyu Zhu, Lei Liu, Yingjie Wang, Hongyuan Li, Min Zang, Jiayu Wang, Yu Tian, Zihan Li. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 29.4.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2026/1/e85917"/><abstract><sec><title>Background</title><p>The high mortality and recurrence rates associated with coronary heart disease (CHD) impose substantial health care costs and economic burdens globally. Identifying effective interventions to improve patient outcomes is paramount. Digital health technologies (DHTs) offer novel solutions to overcome the challenge of low participation rates in traditional cardiac rehabilitation (CR).</p></sec><sec><title>Objective</title><p>This review aims to systematically map the scope of application, intervention objectives, and evaluation metrics of DHTs in CR for patients with CHD, thereby providing a structured evidence base for future research and practice.</p></sec><sec sec-type="methods"><title>Methods</title><p>This scoping review adheres to the Joanna Briggs Institute&#x2019;s methodology and is reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. A systematic search was conducted across 5 major databases, PubMed, Web of Science, Embase, Cochrane Library, and EBSCO, covering the period from inception to February 2026. Inclusion criteria were developed based on the participants, concept, and context framework. Studies focused on the application of various DHTs within CR settings for patients with CHD. Eligible literature comprised randomized controlled trials, quasi-randomized controlled trials, and longitudinal before-and-after studies published in peer-reviewed journals. Two researchers (XZ and ZL) independently conducted literature screening and data extraction. Findings were presented through a comprehensive narrative synthesis and evidence gap maps.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 43 studies were included, predominantly randomized controlled trials (n=40). Findings revealed (1) diverse technological formats, categorized into 3 main types: digital health tools, real-time remote support, and asynchronous communication. Multitechnology combined interventions have become the mainstream model (36/43, 83.7%). (2) Intervention objectives were multifaceted, consolidating into 4 dimensions: motivation and guidance, knowledge and skills, monitoring and security, and social and group dynamics. (3) Evaluation metrics were multidimensional, encompassing clinical physiological indicators, health behaviors, patient-reported outcomes, service use rates, and technological feasibility. DHTs demonstrated positive effects in improving short-term physiological function and health behaviors; however, evidence remains insufficient regarding their impact on long-term clinical outcomes such as reducing adverse events.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>The innovation of this scoping review lies in integrating highly heterogeneous evidence to reveal the field&#x2019;s evolution from isolated tools toward systematic, integrated solutions. Research confirms that DHTs effectively overcome temporal and spatial constraints, enhancing rehabilitation accessibility and engagement. They serve as crucial strategic tools for bridging geographical disparities in health care resources and advancing equity in cardiovascular health services. However, the evidence base remains limited, including insufficient long-term efficacy data and inadequate exploration of vulnerable populations such as older people and those with low digital literacy. Future research urgently requires large-scale, long-term follow-up clinical trials, alongside enhanced studies on adaptability for specific populations and considerations of health equity. This will propel digital CR toward greater scientific rigor, universal applicability, and precision.</p></sec></abstract><kwd-group><kwd>digital health technologies</kwd><kwd>coronary heart disease</kwd><kwd>cardiac rehabilitation</kwd><kwd>scoping review</kwd><kwd>telemedicine</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><sec id="s1-1"><title>Background</title><p>The World Health Organization&#x2019;s (WHO) report on the world&#x2019;s top 10 causes of death indicates that cardiovascular disease (CVD) claims the highest number of lives, with coronary heart disease (CHD) accounting for 13% of global mortality [<xref ref-type="bibr" rid="ref1">1</xref>]. Beyond the health burden, CVD, particularly CHD, imposes a significant economic strain. Globally, CHD accounts for 42% of total CVD expenditure, with annual per capita expenditure on CHD reaching 4.9% to 137.8% of per capita gross domestic product [<xref ref-type="bibr" rid="ref2">2</xref>]. This underscores how CHD has become a &#x201C;heavy burden&#x201D; weighing upon individuals, families, society, and health care systems. More notably, despite substantial investment, the overall prognosis for patients with CHD has yet to improve effectively.</p><p>In response to this challenge, cardiac rehabilitation (CR) has demonstrated significant value as a comprehensive intervention. Research indicates that CR can reduce cardiovascular adverse events by 28%, 1-year readmission rates by 31%, and mortality by 24% while effectively reducing health care expenditure [<xref ref-type="bibr" rid="ref3">3</xref>-<xref ref-type="bibr" rid="ref5">5</xref>]. It is recommended as a class Ia evidence-based intervention in clinical guidelines [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. However, participation rates in CR programs remain universally low among patients with CHD globally [<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref10">10</xref>]. Rates range from 9.7% to 22.5% in Germany, 20% to 30% in the United States, and a mere 41.5% in the United Kingdom [<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref10">10</xref>]. Asian nations present similarly unfavorable figures: Singapore at 12.3% and Japan and South Korea between 14% and 50% [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref11">11</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. As the most populous developing nation, China has CR centers constituting merely 0.06% of all medical institutions, with underdeveloped regions accounting for a mere 8.8% [<xref ref-type="bibr" rid="ref14">14</xref>]. Beyond awareness factors, limitations inherent to traditional CR, such as transport difficulties, time conflicts, and uneven resource distribution, constitute primary barriers to participation [<xref ref-type="bibr" rid="ref15">15</xref>].</p><p>At this intersection of practical need and technological innovation, digital health technologies (DHTs) have transcended the constraints of conventional CR, forging novel pathways for its implementation [<xref ref-type="bibr" rid="ref16">16</xref>]. In 2019, the WHO formally introduced the concept of DHTs, defining them as the field of developing and using digital technologies to disseminate health knowledge and facilitate related practices [<xref ref-type="bibr" rid="ref17">17</xref>]. This encompasses applications of technologies such as the Internet of Things and artificial intelligence within health management [<xref ref-type="bibr" rid="ref17">17</xref>]. Digital devices such as pedometers, accelerometers, and smartphones enable daily activity tracking, exercise intensity assessment, and personalized exercise guidance for patients with CHD [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. Smart pillboxes and &#x201C;digital pills&#x201D; facilitate real-time monitoring of medication adherence [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. Thus, DHTs overcome temporal and spatial constraints to deliver more accessible rehabilitation support. They effectively alleviate resource scarcity issues and hold promise for extending benefits to a broader population with CHD [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>In summary, DHTs offer novel solutions to low CR participation rates. However, their highly heterogeneous delivery formats result in fragmented evidence. Compared to traditional review methodologies, scoping reviews can integrate heterogeneous evidence and define research boundaries [<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref26">26</xref>]. Therefore, in this study, we use a scoping review approach to systematically collate evidence in this field, providing a holistic perspective for subsequent research and policy formulation. This aims to bridge gaps in cardiovascular health accessibility and advance the scientific, universal, and sustainable development of digital CR.</p></sec><sec id="s1-2"><title>Objectives and Research Questions</title><p>In this study, we aim to systematically review the scope of DHT applications in CR for patients with CHD through a scoping literature review methodology. It seeks to provide evidence-based guidance for the diversified development and effective implementation of future CR.</p><p>Our research will clarify (1) the application strategies and scenarios of existing digital technologies in CR for patients with CHD; (2) the key performance indicators determining the effectiveness of current DHT applications, alongside identifying their primary challenges; and (3) how DHTs can be more effectively applied to CR for patients with CHD and future research directions.</p></sec></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Overview</title><p>In this study, we strictly followed the Joanna Briggs Institute&#x2019;s scoping review methodology framework to ensure methodological rigor and transparency in the research process [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. This scoping review adhered strictly to a structured research process, using standardized methodologies to ensure the reliability of findings and their practical applicability. The research involved comprehensive systematic literature searches, data extraction, and evidence synthesis analysis, culminating in a narrative synthesis of studies concerning the application of DHTs in CR for patients with CHD. As a scoping review, our primary objective is to systematically map the current application, intervention formats, and outcome measures of DHTs in CR for patients with CHD. It does not evaluate intervention effectiveness or evidence quality grades; consequently, no rigorous methodological quality assessment of included studies was conducted [<xref ref-type="bibr" rid="ref29">29</xref>]. Our review was reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines [<xref ref-type="bibr" rid="ref26">26</xref>]. The PRISMA-ScR checklist is provided in <xref ref-type="supplementary-material" rid="app2">Checklist 1</xref>.</p></sec><sec id="s2-2"><title>Eligibility Criteria</title><p>The inclusion criteria for this scoping review were based on the Joanna Briggs Institute Scope Review Methodology Guide and structured using the participants, concept, context framework [<xref ref-type="bibr" rid="ref30">30</xref>]. The inclusion and exclusion criteria are presented in <xref ref-type="other" rid="box1">Textbox 1</xref>.</p><boxed-text id="box1"><title> Inclusion and exclusion criteria. Eligibility criteria for the screening and inclusion process, including target population type, research setting, intervention measures, and study type.</title><p><bold>Inclusion criteria</bold></p><list list-type="bullet"><list-item><p>All patients diagnosed with coronary heart disease, irrespective of nationality, gender, or ethnic background. Coronary heart disease encompasses, but is not limited to, the following clinical presentations: stable angina pectoris, acute coronary syndromes (including unstable angina pectoris, non&#x2013;ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction), and patients who have undergone percutaneous coronary intervention or coronary artery bypass grafting.</p></list-item><list-item><p>Focus on the various digital health technologies used in cardiac rehabilitation (CR), including but not limited to mobile health apps, wearable devices, telemedicine or remote monitoring platforms, educational modules delivered via web-based or online platforms, virtual reality, and text messaging.</p></list-item><list-item><p>The context of interest pertains to the application of digital health technologies within CR, where such technologies serve as complementary, alternative, augmenting, or extended means to traditional CR. Their purpose is to support, optimize, or enhance the delivery of CR services. This context is not restricted to specific countries or health care systems, permitting the inclusion of studies from diverse cultural, geographical, or medical settings.</p></list-item><list-item><p>The types of literature included are empirical studies, which must be published in peer-reviewed journals. The study designs encompass randomized controlled trials, quasi-randomized controlled trials, and longitudinal before-and-after studies.</p></list-item></list><p><bold>Exclusion criteria</bold></p><list list-type="bullet"><list-item><p>Research participants who have undergone cardiac or cardiopulmonary transplantation or patients with chronic heart failure.</p></list-item><list-item><p>Studies involving participants younger than 18 years of age.</p></list-item><list-item><p>Non-English language literature, duplicated publications, gray literature, studies where the full text is unavailable, conference abstracts, review papers, or qualitative research.</p></list-item></list></boxed-text></sec><sec id="s2-3"><title>Information Sources</title><p>We conducted systematic searches of the following 5 electronic databases: PubMed, Web of Science (Clarivate), Embase (Elsevier), Cochrane Library (Wiley), and EBSCO (EBSCOhost). Searches were performed independently within each database interface, without using cross-database simultaneous search functionality.</p></sec><sec id="s2-4"><title>Search Strategy</title><p>The literature search process for this study was reported in accordance with the PRISMA-S (extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews) guidelines [<xref ref-type="bibr" rid="ref31">31</xref>]. The search strategy was independently developed by the research team based on the databases&#x2019; subject term lists, without direct adaptation or use of other published scoping review strategies. The complete search strategies for each database are detailed in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. The researchers first conducted a preliminary search in the PubMed database to expand the keywords and use MeSH to determine standardized subject terms. Following this, a search strategy was developed, and an initial search was conducted in PubMed, with a brief analysis of the results. Two researchers collaboratively developed the final search strategy, which was reviewed by a third researcher. The PubMed search strategy is detailed in <xref ref-type="other" rid="box2">Textbox 2</xref>. To maintain sensitivity, no restrictions were applied regarding study design, language, or publication type. The search time frame spanned from the inception of each database to February 2026. Furthermore, as this scoping review aimed to map published evidence to delineate the existing evidence base, clinical trial registries were excluded from the search.</p><boxed-text id="box2"><title> PubMed search strategy.</title><p>((((((((((((((((&#x201C;Coronary Disease&#x201D;[Mesh]) OR (&#x201C;Myocardial Infarction&#x201D;[Mesh])) OR (&#x201C;Coronary Artery Disease&#x201D;[Mesh])) OR (&#x201C;Coronary Heart Disease*&#x201C;[Title/Abstract])) OR (&#x201C;Heart Attack*&#x201C;[Title/Abstract])) OR (&#x201C;Myocardial Infarct*&#x201C;[Title/Abstract])) OR (&#x201C;Cardiovascular Stroke*&#x201C;[Title/Abstract])) OR (&#x201C;acute coronary syndrome&#x201D;[Title/Abstract])) OR (&#x201C;angina pectoris&#x201D;[Title/Abstract])) OR (&#x201C;STEMI&#x201D;[Title/Abstract])) OR (&#x201C;NSTEMI&#x201D;[Title/Abstract])) OR (&#x201C;PCI&#x201D;[Title/Abstract])) OR (&#x201C;percutaneous coronary intervention&#x201D;[Title/Abstract])) OR (&#x201C;CABG&#x201D;[Title/Abstract])) OR (&#x201C;coronary artery bypass grafting&#x201D;[Title/Abstract]))</p><p>AND</p><p>((((((((((((((((((((((((((((((((&#x201C;Telemedicine&#x201D;[Mesh]) OR (&#x201C;Wearable Electronic Devices&#x201D;[Mesh])) OR (&#x201C;Digital Health&#x201D;[Mesh])) OR (&#x201C;Remote Patient Monitoring&#x201D;[Mesh])) OR (&#x201C;Text Messaging&#x201D;[Mesh])) OR (&#x201C;Virtual Medicine&#x201D;[Title/Abstract])) OR (&#x201C;Tele-Referral*&#x201C;[Title/Abstract])) OR (&#x201C;Mobile Health&#x201D;[Title/Abstract])) OR (&#x201C;mHealth&#x201D;[Title/Abstract])) OR (&#x201C;Telehealth&#x201D;[Title/Abstract])) OR (&#x201C;eHealth&#x201D;[Title/Abstract])) OR (&#x201C;Tele Intensive Care&#x201D;[Title/Abstract])) OR (&#x201C;Tele Care&#x201D;[Title/Abstract])) OR (&#x201C;Wearable Device*&#x201C;[Title/Abstract])) OR (&#x201C;Wearable Technolog*&#x201C;[Title/Abstract])) OR (&#x201C;Wearable Computer&#x201D;[Title/Abstract])) OR (&#x201C;Digital Health Technolog*&#x201C;[Title/Abstract])) OR (&#x201C;Health Technolog*&#x201C;[Title/Abstract])) OR (&#x201C;Short Message Service&#x201D;[Title/Abstract])) OR (&#x201C;digital therapeutics&#x201D;[Title/Abstract])) OR (&#x201C;smartwatch&#x201D;[Title/Abstract])) OR (&#x201C;fitness tracker&#x201D;[Title/Abstract])) OR (&#x201C;activity tracker&#x201D;[Title/Abstract])) OR (&#x201C;tele-rehabilitation&#x201D;[Title/Abstract])) OR (&#x201C;virtual care&#x201D;[Title/Abstract])) OR (&#x201C;mobile phone&#x201D;[Title/Abstract])) OR (&#x201C;cell phone&#x201D;[Title/Abstract])) OR (&#x201C;application&#x201D;[Title/Abstract])) OR (&#x201C;internet-based&#x201D;[Title/Abstract])) OR (&#x201C;web-based&#x201D;[Title/Abstract])) OR (&#x201C;online program&#x201D;[Title/Abstract])))</p><p>AND</p><p>((((((((((((((((((&#x201C;Cardiac Rehabilitation&#x201D;[Mesh]) OR (&#x201C;Secondary Prevention&#x201D;[Mesh])) OR (&#x201C;Cardiac Rehabilitation*&#x201C;[Title/Abstract])) OR (&#x201C;Cardiovascular Rehabilitation*&#x201C;[Title/Abstract])) OR (&#x201C;Secondary Prevention*&#x201C;[Title/Abstract])) OR (&#x201C;Disease Prevention*&#x201C;[Title/Abstract])) OR (&#x201C;Secondary Disease Prevention*&#x201C;[Title/Abstract])) OR (&#x201C;Early Therap*&#x201C;[Title/Abstract])) OR (&#x201C;Relapse Prevention*&#x201C;[Title/Abstract])) OR (&#x201C;exercise training&#x201D;[Title/Abstract])) OR (&#x201C;physical activity&#x201D;[Title/Abstract])) OR (&#x201C;lifestyle modification&#x201D;[Title/Abstract])) OR (&#x201C;behavior change&#x201D;[Title/Abstract])) OR (&#x201C;self-management&#x201D;[Title/Abstract])) OR (&#x201C;Exercise Therapy&#x201D;[Title/Abstract])) OR (&#x201C;Patient Education&#x201D;[Title/Abstract])) OR (&#x201C;Risk Factor Management&#x201D;[Title/Abstract])) OR (&#x201C;Medication Adherence&#x201D;[Title/Abstract]))</p></boxed-text></sec><sec id="s2-5"><title>Selection of Sources</title><p>The literature retrieval and screening process were independently conducted by 2 researchers trained in evidence-based medicine and possessing cardiovascular research experience, with the entire procedure subject to third-party oversight. The specific workflow was as follows: (1) Search results from all databases were imported into EndNote (Clarivate) reference management software, which automatically identified and excluded duplicate records; (2) 2 researchers independently conducted an initial screening of the remaining literature based on predefined inclusion and exclusion criteria, reviewing titles and abstracts; (3) screening results were cross-checked; discrepancies were resolved through third-party discussion until consensus was reached; and (4) full-text evaluation of initially selected papers determined final inclusion in the study.</p></sec><sec id="s2-6"><title>Data Charting Process and Items</title><p>Data extraction was conducted using predesigned standardized forms by 2 researchers independently using Microsoft Excel to extract content covering the following core elements: (1) basic information: author, year of publication, and country; (2) study design: study type, sample size, follow-up duration, and control group configuration; (3) population characteristics: disease type; (4) intervention details: type of DHT, intervention duration, frequency of use, combination use, and combination method; (5) intervention objective; (6) outcome measures: primary outcomes and secondary outcomes; and (7) key findings: intervention effectiveness. In the event of disagreement during data extraction, a third researcher shall arbitrate the resolution.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Selection of Sources of Evidence</title><p>As illustrated in <xref ref-type="fig" rid="figure1">Figure 1</xref>, this study strictly adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) process for literature screening [<xref ref-type="bibr" rid="ref32">32</xref>]. The initial search yielded 8156 publications. After removing 2320 duplicates using EndNote, 2 researchers (XZ and ZL) independently screened titles and abstracts. Based on predefined inclusion criteria, 5836 publications were excluded. The remaining 407 publications underwent full-text assessment, resulting in the exclusion of 364 publications that did not meet the requirements. Ultimately, 43 studies were included in the analysis.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA flow diagram showing the identification of sources from databases and the screening and inclusion processes. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v28i1e85917_fig01.png"/></fig></sec><sec id="s3-2"><title>Characteristics of Sources of Evidence</title><p><xref ref-type="fig" rid="figure2">Figure 2</xref> presents an overview of the 43 included studies by year and geographical distribution. The publication span of the included studies ranges from 2014 to 2026, with a marked increase in relevant research since 2021, with 60.5% of studies published from 2021 to 2026. The geographical coverage spans 18 countries, with China accounting for the highest proportion of studies at 34.9% (15/43) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref46">46</xref>].</p><p>Of the 43 studies included in total, the vast majority used randomized controlled designs, comprising 33 randomized controlled trials [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref69">69</xref>] and 7 randomized controlled pilot studies [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref70">70</xref>-<xref ref-type="bibr" rid="ref72">72</xref>]. Among the remaining studies, 2 were quasi-randomized controlled trials [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref73">73</xref>], and 1 was a controlled before-and-after study [<xref ref-type="bibr" rid="ref74">74</xref>]. Detailed characteristics of the studies included in this scoping review are presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Publication trends for the 43 included studies by country and year (2014&#x2010;2026).</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v28i1e85917_fig02.png"/></fig><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Study characteristics<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup>.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Author (year)</td><td align="left" valign="bottom">Country</td><td align="left" valign="bottom">Design</td><td align="left" valign="bottom">Population (sample size)</td><td align="left" valign="bottom">Type and duration of intervention</td><td align="left" valign="bottom">Outcome measures</td><td align="left" valign="bottom">Statistically significant</td><td align="left" valign="bottom">Forms of intervention</td><td align="left" valign="bottom">Objectives of the intervention</td></tr></thead><tbody><tr><td align="left" valign="top">Krzowski et al (2023) [<xref ref-type="bibr" rid="ref47">47</xref>]</td><td align="left" valign="top">Poland</td><td align="left" valign="top">RCT<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">Patients after acute myocardial infarction (n=100)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard rehabilitation+afterAMI app</p></list-item><list-item><p>Control group: Standard rehabilitation</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Rehospitalization or emergency department attendance within 6 months</p></list-item><list-item><p>Secondary: Risk factor control, NT-proBNP<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup>, disease knowledge</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Data monitor</p></list-item></list></td></tr><tr><td align="left" valign="top">Hong et al (2021) [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=60)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Health IT system grounded in self-efficacy theory+self-monitoring devices+fortnightly telephone interviews</p></list-item><list-item><p>Control group: Standard care (receiving identical intervention after a waiting period)</p></list-item></list><list list-type="bullet"><list-item><p>Duration: 3-month intervention period, 6-month follow-up</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Systolic blood pressure at 3 months</p></list-item><list-item><p>Secondary: Self-management behaviors, quality of life, diastolic blood pressure</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Ensuring safety</p></list-item></list></td></tr><tr><td align="left" valign="top">Chan et al (2022) [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients with stable coronary artery disease (n=139)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: 15-minute face-to-face ZTEx introduction+ZTEX email+ZTEX app</p></list-item><list-item><p>Control group: Equivalent duration and quantity of information on healthy eating and breathing exercises</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Physical activity (IPAQ<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup>), physical fitness</p></list-item><list-item><p>Secondary: Self-efficacy in exercise, well-being, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Social media platform</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Varnfield et al (2014) [<xref ref-type="bibr" rid="ref48">48</xref>]</td><td align="left" valign="top">Australia</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after myocardial infarction (n=120)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: CAP-CR</p></list-item><list-item><p>Control group: Traditional centralized CR<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></p></list-item><list-item><p>Duration: 6-week intervention period, followed by a 6-month maintenance phase</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Rehabilitation acceptance rate, adherence rate, completion rate</p></list-item><list-item><p>Secondary: Lifestyle factors, clinical indicators, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Digital video</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Goal setting</p></list-item></list></td></tr><tr><td align="left" valign="top">Duan et al (2018) [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients with coronary artery disease (n=136)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: An 8-week web-based intervention grounded in the health action process approach (HAPA) model</p></list-item><list-item><p>Control group: A waiting-list control group</p></list-item><list-item><p>Duration: 8 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Physical activity, fruit and vegetable intake</p></list-item><list-item><p>Secondary: Healthy lifestyle, social cognitive indicators, health outcomes</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Peer effect</p></list-item><list-item><p>Feedback</p></list-item></list></td></tr><tr><td align="left" valign="top">Xu et al (2024) [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with CHD<sup><xref ref-type="table-fn" rid="table1fn6">f</xref></sup> after PCI<sup><xref ref-type="table-fn" rid="table1fn7">g</xref></sup> (n=147)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Remote rehabilitation strategy based on the SCeiP<sup><xref ref-type="table-fn" rid="table1fn8">h</xref></sup> model</p></list-item><list-item><p>Control group: Standard exercise rehabilitation</p></list-item><list-item><p>Duration: 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Exercise adherence (number of days, duration)</p></list-item><list-item><p>Secondary: CR awareness, exercise program, exercise commitment</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media platform</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Remotely adjust prescription</p></list-item></list></td></tr><tr><td align="left" valign="top">Avila et al (2018) [<xref ref-type="bibr" rid="ref49">49</xref>]</td><td align="left" valign="top">Belgium</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=90)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group 1: Home-based rehabilitation+remote monitoring</p></list-item><list-item><p>Intervention group 2: In-hospital rehabilitation</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Peak oxygen uptake (VO<sub>2</sub> max)</p></list-item><list-item><p>Secondary: Physical activity, risk factors, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Email</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Goal setting</p></list-item></list></td></tr><tr><td align="left" valign="top">Nishio et al (2025) [<xref ref-type="bibr" rid="ref70">70</xref>]</td><td align="left" valign="top">Japan</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients with coronary artery disease (n=50)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Wearable device + real-time monitoring+weekly text message and monthly videoconference guidance</p></list-item><list-item><p>Control group: Wearable device only</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Changes in VO<sub>2</sub> max and anaerobic threshold oxygen uptake</p></list-item><list-item><p>Secondary: Daily activities, anxiety, quality of life</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>SMS text messaging</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Li et al (2022) [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients with coronary artery disease (n=300)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Traditional follow-up+self-management app</p></list-item><list-item><p>Control group: Traditional hospital follow-up</p></list-item><list-item><p>Duration: 1 year</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Proportion of patients receiving all guideline-recommended medications at 12 months</p></list-item><list-item><p>Secondary: Proportion receiving medication at 6 months, lipid control rate, blood pressure control rate</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Cruz-Cobo et al (2024) [<xref ref-type="bibr" rid="ref50">50</xref>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with acute coronary syndrome after PCI (n=300)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care + eMOTIVA app</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Mediterranean diet adherence, physical activity, sedentary time, functional capacity, smoking cessation, disease knowledge, app satisfaction</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Remote counseling sessions</p></list-item><list-item><p>Digital video</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Gamification</p></list-item><list-item><p>Reward mechanism</p></list-item></list></td></tr><tr><td align="left" valign="top">Bernal-Jim&#x00E9;nez et al (2024) [<xref ref-type="bibr" rid="ref51">51</xref>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with CHD after PCI (n=128)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+Interactive mHealth App (EVITE app)</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 9 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Mediterranean diet adherence, food frequency, physical activity, smoking, knowledge, treatment adherence, quality of life, satisfaction</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Remote counseling sessions</p></list-item><list-item><p>Email</p></list-item><list-item><p>Telephone</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Feedback</p></list-item></list></td></tr><tr><td align="left" valign="top">Bae et al (2021) [<xref ref-type="bibr" rid="ref52">52</xref>]</td><td align="left" valign="top">Korea</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after the first PCI (n=879)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care + website + 4 weekly lifestyle text messages</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Low-density lipoprotein cholesterol, systolic blood pressure, BMI</p></list-item><list-item><p>Secondary: Lifestyle modifications, adherence to health behaviors</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Su and Yu (2021) [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=146)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+NeCR</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Lifestyle behavior changes</p></list-item><list-item><p>Secondary: Self-efficacy, quality of life, physiological indicators</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media platform</p></list-item><list-item><p>Remote counseling sessions</p></list-item><list-item><p>Digital video</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Emotional support or counseling</p></list-item></list></td></tr><tr><td align="left" valign="top">Dodson et al (2025) [<xref ref-type="bibr" rid="ref53">53</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients aged 65 years or older with ischemic heart disease (n=400)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: mHealth-CR software on tablet devices+remote monitoring+weekly telephone guidance</p></list-item><list-item><p>Control group: standard care</p></list-item><list-item><p>Duration: 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Change in 6MWD<sup><xref ref-type="table-fn" rid="table1fn9">i</xref></sup> from baseline to 3 months</p></list-item><list-item><p>Secondary: Health status, residual angina, impairment in activities of daily living</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Remote counseling sessions</p></list-item><list-item><p>Telephone</p></list-item><list-item><p>Wearable devices</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Data monitor</p></list-item></list></td></tr><tr><td align="left" valign="top">Dorje et al (2019) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with CHD after PCI (n=312)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: SMART-CR/SP</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Change in 6MWD at 2 months and 6 months</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media platform</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Hisam et al (2022) [<xref ref-type="bibr" rid="ref54">54</xref>]</td><td align="left" valign="top">Pakistan</td><td align="left" valign="top">RCT</td><td align="left" valign="top">After an acute coronary syndrome (n=160)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+MCard</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 24 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Health-related quality of life</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Emotional support or counseling</p></list-item></list></td></tr><tr><td align="left" valign="top">Zheng et al (2024) [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with CHD after PCI (n=106)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+HCT</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: 6-minute walk test, quality of life (SF-12<sup><xref ref-type="table-fn" rid="table1fn10">j</xref></sup>), disease burden (FBIS<sup><xref ref-type="table-fn" rid="table1fn11">k</xref></sup>), cardiac function (LVEF<sup><xref ref-type="table-fn" rid="table1fn12">l</xref></sup>)</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Remotely adjust prescription</p></list-item><list-item><p>Feedback</p></list-item></list></td></tr><tr><td align="left" valign="top">Ma et al (2021) [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Q-RCT<sup><xref ref-type="table-fn" rid="table1fn13">m</xref></sup></td><td align="left" valign="top">Patients with CHD after PCI (n=335)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: HBCR</p></list-item><list-item><p>Control group: Routine care</p></list-item><list-item><p>Duration: 42 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Incidence of major adverse cardiovascular and stroke events</p></list-item><list-item><p>Secondary: Exercise capacity, quality of life, risk factor control</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Digital video</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Training courses</p></list-item><list-item><p>Ensuring safety</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Xu et al (2024) [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=108)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group 1 (individual): Gamified intervention</p></list-item><list-item><p>Intervention group 2 (team): Gamification+social interaction</p></list-item><list-item><p>Control group: Daily step target</p></list-item><list-item><p>Duration: 12-week intervention, 12-week follow-up</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Daily step count variation, proportion of days achieving target</p></list-item><list-item><p>Secondary: Autonomy, sense of connection, intrinsic motivation</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Goal setting</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Reward mechanism</p></list-item><list-item><p>Gamification</p></list-item></list></td></tr><tr><td align="left" valign="top">Widmer et al (2017) [<xref ref-type="bibr" rid="ref55">55</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with acute coronary syndrome after PCI (n=80)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard CR+DHI</p></list-item><list-item><p>Control group: Standard CR</p></list-item><list-item><p>Duration: 3-month intervention, 6-month outcome assessment</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Related emergency department visits and readmissions</p></list-item><list-item><p>Secondary: Risk factors and lifestyle factors at 90 days</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item></list></td></tr><tr><td align="left" valign="top">Yudi et al (2021) [<xref ref-type="bibr" rid="ref56">56</xref>]</td><td align="left" valign="top">Australia</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with acute coronary syndromes (n=206)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+S-CRP</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 8 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Change in 6MWD at 8 weeks</p></list-item><list-item><p>Secondary: CR participation, risk factors, psychological indicators</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Ensuring safety</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Gallagher et al (2023) [<xref ref-type="bibr" rid="ref57">57</xref>]</td><td align="left" valign="top">Australia</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=390)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: MyHeartMate app</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Self-reported physical activity (METs<sup><xref ref-type="table-fn" rid="table1fn14">n</xref></sup>)</p></list-item><list-item><p>Secondary: Blood lipids, blood pressure, BMI, smoking</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Digital video</p></list-item><list-item><p>Email</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gamification</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Reward mechanism</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Wohlfahrt et al (2024) [<xref ref-type="bibr" rid="ref71">71</xref>]</td><td align="left" valign="top">Czech Republic</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients after myocardial infarction (n=64)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Smartwatch step tracking+remote monitoring by nurses</p></list-item><list-item><p>Control group: 150 minutes per week of moderate-intensity exercise recommendation</p></list-item><list-item><p>Duration: 3 months, followed by crossover after 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: VO<sub>2</sub> max</p></list-item><list-item><p>Secondary: Body weight, 6MWD, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Goal setting</p></list-item></list></td></tr><tr><td align="left" valign="top">Ramachandran et al (2025) [<xref ref-type="bibr" rid="ref72">72</xref>]</td><td align="left" valign="top">Singapore</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients after acute myocardial infarction (n=50)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Home-based remote rehabilitation</p></list-item><list-item><p>Control group: Centralized CR</p></list-item><list-item><p>Duration: 6 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Use of CR</p></list-item><list-item><p>Secondary: Functional capacity, risk factors, self-reported behaviors</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Website</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Telephone</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Remotely adjust prescription</p></list-item></list></td></tr><tr><td align="left" valign="top">Jo et al (2024) [<xref ref-type="bibr" rid="ref58">58</xref>]</td><td align="left" valign="top">Korea</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after acute myocardial infarction (n=48)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Mobile app-based rehabilitation</p></list-item><list-item><p>Control group: Conventional home-based rehabilitation+biweekly telephone supervision</p></list-item><list-item><p>Duration: 6 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: VO<sub>2</sub> max</p></list-item><list-item><p>Secondary: Resting heart rate, blood pressure, quality of life, psychological indicators</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Telephone</p></list-item><list-item><p>Wearable devices</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Ensuring safety</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Fallah et al (2025) [<xref ref-type="bibr" rid="ref59">59</xref>]</td><td align="left" valign="top">Iran</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with myocardial infarction (n=144)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: HAPA-based mobile app</p></list-item><list-item><p>Control group: No specific intervention</p></list-item><list-item><p>Duration: 8 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Physical activity (IPAQ)</p></list-item><list-item><p>Secondary: HAPA-related psychological constructs</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Li et al (2023) [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT pilot</td><td align="left" valign="top">Patients with acute myocardial infarction after PCI (n=60)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: 5G IoT platform</p></list-item><list-item><p>Control group: Conventional CR training within the hospital.</p></list-item><list-item><p>Duration: 3 months.</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Cardiorespiratory fitness (VO<sub>2</sub> max, MET)</p></list-item><list-item><p>Secondary: Physiological indicators, psychological indicators, adherence, satisfaction.</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item><list-item><p>Wearable devices</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Remotely adjust prescription</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Emotional support or counseling</p></list-item></list></td></tr><tr><td align="left" valign="top">Waranski et al (2024) [<xref ref-type="bibr" rid="ref73">73</xref>]</td><td align="left" valign="top">Germany</td><td align="left" valign="top">Q-RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=169)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Personalized messages (twice weekly)</p></list-item><list-item><p>Control group: Routine outpatient care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Routine physical activity (&#x2265;150 minutes per week) and daily activities at 6 months</p></list-item><list-item><p>Secondary: Psychological indicators, self-efficacy, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>SMS text messaging</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Goal setting</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Ni et al (2022) [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=230)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: WeChat+Message Express</p></list-item><list-item><p>Control group: WeChat only</p></list-item><list-item><p>Duration: 60-day intervention, 30-day follow-up</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Medication Adherence Score (Voils Extent Scale)</p></list-item><list-item><p>Secondary: Heart rate, systolic blood pressure, diastolic blood pressure</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>SMS text messaging</p></list-item><list-item><p>Social media platform</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Liu et al (2026) [<xref ref-type="bibr" rid="ref44">44</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after PCI (n=180)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard rehabilitation+eHealth platform based on the Persuasive systems design (PSD) model</p></list-item><list-item><p>Control group: Standard rehabilitation</p></list-item><list-item><p>Duration: 12-week intervention, 12-week follow-up</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Physical activity level (IPAQ)</p></list-item><list-item><p>Secondary: Exercise endurance (6MWD), self-perceived fatigue, exercise self-efficacy, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Social media platform</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Bruggmann et al (2021) [<xref ref-type="bibr" rid="ref60">60</xref>]</td><td align="left" valign="top">Switzerland</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with acute coronary syndromes (n=60)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Routine care+viewing of interactive video+brief interview with pharmacist</p></list-item><list-item><p>Control group: Routine care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Differences in medication adherence at 1, 3, and 6 months (ARMS<sup><xref ref-type="table-fn" rid="table1fn15">o</xref></sup>)</p></list-item><list-item><p>Secondary: Disease knowledge, readmission, emergency department visits, satisfaction</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item><list-item><p>Feedback</p></list-item></list></td></tr><tr><td align="left" valign="top">Zhang et al (2025) [<xref ref-type="bibr" rid="ref45">45</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=62)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Smartwatch-assisted CR</p></list-item><list-item><p>Control group: Standard CR</p></list-item><list-item><p>Duration: 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: HBCR adherence (HETAQ<sup><xref ref-type="table-fn" rid="table1fn16">p</xref></sup>)</p></list-item><list-item><p>Secondary: cardiopulmonary function, anxiety, depression, quality of life</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Patterson et al (2023) [<xref ref-type="bibr" rid="ref61">61</xref>]</td><td align="left" valign="top">Australia</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=120)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Conventional rehabilitation+Vire app</p></list-item><list-item><p>Control group: Conventional rehabilitation</p></list-item><list-item><p>Duration: 12 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Nonelective hospital admissions and emergency department visits</p></list-item><list-item><p>Secondary: Sedentary behavior, BMI, waist circumference, quality of life, cost-effectiveness</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Batalik et al (2020) [<xref ref-type="bibr" rid="ref62">62</xref>]</td><td align="left" valign="top">Czech Republic</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=56)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Home-based remote rehabilitation</p></list-item><list-item><p>Control group: Routine outpatient rehabilitation</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: VO<sub>2</sub> max</p></list-item><list-item><p>Secondary: Quality of life (SF-36<sup><xref ref-type="table-fn" rid="table1fn17">q</xref></sup>), training adherence</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Emotional support or counseling</p></list-item></list></td></tr><tr><td align="left" valign="top">Dalli Peydr&#x00F3; et al (2022) [<xref ref-type="bibr" rid="ref63">63</xref>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with acute coronary syndromes (n=67)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Remote CR</p></list-item><list-item><p>Control group: Center-based CR</p></list-item><list-item><p>Duration: 8 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Self-reported physical activity (IPAQ)</p></list-item><list-item><p>Secondary: VO<sub>2</sub> max, blood lipids, body weight, quality of life, time to return to work</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Personalization</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Bravo-Escobar et al (2017) [<xref ref-type="bibr" rid="ref64">64</xref>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with stable, intermediate-risk coronary artery disease (n=28)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Weekly hospital sessions+3 home training sessions</p></list-item><list-item><p>Control group: Routine hospital rehabilitation (3 sessions per week)</p></list-item><list-item><p>Duration: 2 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Physical fitness, risk profile, cardiovascular complications, quality of life</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Partially valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Goal setting</p></list-item></list></td></tr><tr><td align="left" valign="top">Widmer et al (2015) [<xref ref-type="bibr" rid="ref74">74</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">CBA<sup><xref ref-type="table-fn" rid="table1fn18">r</xref></sup></td><td align="left" valign="top">Patients after myocardial infarction (n=42)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group 1: During CR+PHA</p></list-item><list-item><p>Intervention group 2: Following CR+PHA</p></list-item><list-item><p>Control group: Standard CR during the corresponding time period</p></list-item><list-item><p>Duration: 3 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Changes in risk factors and readmissions or emergency department visits after 3 months</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Health education</p></list-item></list></td></tr><tr><td align="left" valign="top">Johnston et al (2016) [<xref ref-type="bibr" rid="ref65">65</xref>]</td><td align="left" valign="top">Sweden</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after myocardial infarction (n=174)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Full-featured CR app</p></list-item><list-item><p>Control group: Simplified version app</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Nonadherence score based on app records</p></list-item><list-item><p>Secondary: Risk factors, quality of life, device satisfaction</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>SMS text messaging</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Health education</p></list-item></list></td></tr><tr><td align="left" valign="top">Kumar et al (2024) [<xref ref-type="bibr" rid="ref66">66</xref>]</td><td align="left" valign="top">India</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after CABG (n=40)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: eMedia-supported exercise rehabilitation</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 12 weeks</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Functional capacity (6MWT), quality of life (WHOQOL-BREF<sup><xref ref-type="table-fn" rid="table1fn19">s</xref></sup>), physical activity (GPAQ<sup><xref ref-type="table-fn" rid="table1fn20">t</xref></sup>)</p></list-item><list-item><p>Secondary: No</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Website</p></list-item><list-item><p>App</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Feedback</p></list-item><list-item><p>Health education</p></list-item><list-item><p>Ensuring safety</p></list-item><list-item><p>Data monitor</p></list-item></list></td></tr><tr><td align="left" valign="top">Bretschneider et al (2024) [<xref ref-type="bibr" rid="ref67">67</xref>]</td><td align="left" valign="top">Germany</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=354)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care plus Mebix</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 12 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Disease-specific quality of life (HeartQoL<sup><xref ref-type="table-fn" rid="table1fn21">u</xref></sup>) and body weight</p></list-item><list-item><p>Secondary: Cardiovascular risk, occupational prognosis</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>SMS text messaging</p></list-item><list-item><p>Telephone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Herring et al (2021) [<xref ref-type="bibr" rid="ref68">68</xref>]</td><td align="left" valign="top">Britain</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=291)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: 2 structured educational sessions+follow-up text message support</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 12 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Changes in overall physical activity at 12 months (GENEActiv)</p></list-item><list-item><p>Secondary: Functional, cardiovascular, biochemical, and patient-reported outcomes</p></list-item></list></td><td align="left" valign="top">Invalid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Group meeting</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr><tr><td align="left" valign="top">Li et al (2025) [<xref ref-type="bibr" rid="ref46">46</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients with coronary artery disease (n=294)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Personalized face-to-face education+i-CARE app+pedometer</p></list-item><list-item><p>Control group: Standard care+pedometer</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Self-care behavior in CHD (SC-CHDI<sup><xref ref-type="table-fn" rid="table1fn22">v</xref></sup>)</p></list-item><list-item><p>Secondary: Health status, quality of life, physiological indicators</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Health education</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Khikmatova Madina et al [<xref ref-type="bibr" rid="ref69">69</xref>] (2025)</td><td align="left" valign="top">Uzbekistan</td><td align="left" valign="top">RCT</td><td align="left" valign="top">Patients after myocardial infarction (n=300)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention group: Standard care+wearable activity monitoring device and accompanying app</p></list-item><list-item><p>Control group: Standard care</p></list-item><list-item><p>Duration: 6 months</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Primary: Rehabilitation adherence</p></list-item><list-item><p>Secondary: Readmission rate, mortality rate, ejection fraction, exercise capacity</p></list-item></list></td><td align="left" valign="top">Valid</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>App</p></list-item><list-item><p>Wearable devices</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Data monitor</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Alerts and reminders</p></list-item></list></td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>Information regarding authors, publication year, participants, study design, study outcomes, and methodology for 43 studies. Digital health technology intervention name: zero-time exercise (ZTEx), care assessment platform of cardiac rehabilitation (CAP-CR), nurse-led eHealth cardiac rehabilitation (NeCR), mobile health cardiac rehabilitation (mHealth-CR), smartphone and social media&#x2013;based cardiac rehabilitation and secondary prevention (SMART-CR/SP), mobile health augmented cardiac rehabilitation (MCard), home-based cardiac telerehabilitation (HCT), home-based cardiac rehabilitation (HBCR), digital health intervention (DHI), smartphone-based cardiac rehabilitation program (S-CRP), fifth generation mobile communication technology Internet of Things platform (5G IoT platform), persuasive systems design (PSD), coronary artery bypass grafting (CABG), internet-based cardiac rehabilitation enhancement (i-CARE).</p></fn><fn id="table1fn2"><p><sup>b</sup>RCT: randomized controlled trial.</p></fn><fn id="table1fn3"><p><sup>c</sup>NT-proBNP: N-terminal pro-brain natriuretic peptide.</p></fn><fn id="table1fn4"><p><sup>d</sup>IPAQ: International Physical Activity Questionnaire.</p></fn><fn id="table1fn5"><p><sup>e</sup>CR: cardiac rehabilitation.</p></fn><fn id="table1fn6"><p><sup>f</sup>CHD: coronary heart disease.</p></fn><fn id="table1fn7"><p><sup>g</sup>PCI: percutaneous coronary intervention.</p></fn><fn id="table1fn8"><p><sup>h</sup>SCeiP: Self-Monitoring, Coaching, e-Health, Interactive Feedback, and Personalization.</p></fn><fn id="table1fn9"><p><sup>i</sup>6MWD: 6-minute walk distance.</p></fn><fn id="table1fn10"><p><sup>j</sup>SF-12: Short Form 12 Health Survey.</p></fn><fn id="table1fn11"><p><sup>k</sup>FBIS: Framingham Burden of Illness Scale.</p></fn><fn id="table1fn12"><p><sup>l</sup>LVEF: left ventricular ejection fraction.</p></fn><fn id="table1fn13"><p><sup>m</sup>Q-RCT: quasi-randomized controlled trial.</p></fn><fn id="table1fn14"><p><sup>n</sup>MET: metabolic equivalents of task.</p></fn><fn id="table1fn15"><p><sup>o</sup>ARMS: Adherence to Refills and Medications Scale.</p></fn><fn id="table1fn16"><p><sup>p</sup>HETAQ: Home-Based Cardiac Rehabilitation Adherence Questionnaire.</p></fn><fn id="table1fn17"><p><sup>q</sup>SF-36: Short Form 36 Health Survey.</p></fn><fn id="table1fn18"><p><sup>r</sup>CBA: controlled before-after study.</p></fn><fn id="table1fn19"><p><sup>s</sup>WHOQOL-BREF: World Health Organization Quality of Life-BREF.</p></fn><fn id="table1fn20"><p><sup>t</sup>GPAQ: Global Physical Activity Questionnaire.</p></fn><fn id="table1fn21"><p><sup>u</sup>HeartQoL: Heart Disease-Specific Quality of Life Questionnaire.</p></fn><fn id="table1fn22"><p><sup>v</sup>SC-CHDI: Self-Care Behaviour in Coronary Heart Disease Inventory.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Results of Individual Sources of Evidence</title><p>In this study, we analyzed data from 43 research papers and generated an evidence gap map (<xref ref-type="table" rid="table2">Table 2</xref>) illustrating the application forms and objectives of DHT interventions.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Evidence gap analysis of digital health technologies in cardiac rehabilitation for patients with coronary heart disease, based on 43 included studies.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="top">Author (year)</td><td align="left" valign="top" colspan="10">Forms of intervention</td><td align="left" valign="top" colspan="16">Objectives of the intervention</td></tr></thead><tbody><tr><td align="left" valign="top"/><td align="left" valign="top">Wearable devices</td><td align="left" valign="top">Application</td><td align="left" valign="top">Website</td><td align="left" valign="top">Digital video</td><td align="left" valign="top">Social media platform</td><td align="left" valign="top">Telephone</td><td align="left" valign="top">Group meeting</td><td align="left" valign="top">Remote counseling sessions</td><td align="left" valign="top">Email</td><td align="left" valign="top">SMS text messaging</td><td align="left" valign="top">Goal setting</td><td align="left" valign="top">Feedback</td><td align="left" valign="top">Reward mechanism</td><td align="left" valign="top">Gamification</td><td align="left" valign="top">Alerts and reminders</td><td align="left" valign="top">Personalization</td><td align="left" valign="top">Health education</td><td align="left" valign="top">Training courses</td><td align="left" valign="top">Data monitor</td><td align="left" valign="top">Real-time monitoring</td><td align="left" valign="top">Ensuring safety</td><td align="left" valign="top">Remotely adjust prescription</td><td align="left" valign="top">Peer effect</td><td align="left" valign="top">Social support</td><td align="left" valign="top">Emotional support</td><td align="left" valign="top">Counseling</td></tr><tr><td align="left" valign="top">Krzowski et al (2023) [<xref ref-type="bibr" rid="ref47">47</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Hong et al (2021) [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Chan et al (2022) [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Varnfield et al (2014) [<xref ref-type="bibr" rid="ref48">48</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Duan et al (2018) [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Xu et al (2024) [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Avila et al (2018) [<xref ref-type="bibr" rid="ref49">49</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Nishio et al (2025) 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ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Cruz-Cobo et al (2024) [<xref ref-type="bibr" rid="ref50">50</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Bernal-Jim&#x00E9;nez et al (2024) [<xref ref-type="bibr" rid="ref51">51</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Bae et al (2021) [<xref ref-type="bibr" rid="ref52">52</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Su and Yu (2021) [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td></tr><tr><td align="left" valign="top">Dodson et al (2025) [<xref ref-type="bibr" rid="ref53">53</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Dorje et al (2019) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Hisam et al (2022) [<xref ref-type="bibr" rid="ref54">54</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td></tr><tr><td align="left" valign="top">Zheng et al (2024) [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Ma et al (2021) [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Xu et al (2024) [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Widmer et al (2017) [<xref ref-type="bibr" rid="ref55">55</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Yudi et al (2021) [<xref ref-type="bibr" rid="ref56">56</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Gallagher et al (2023) [<xref ref-type="bibr" rid="ref57">57</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Wohlfahrt et al (2024) [<xref ref-type="bibr" rid="ref71">71</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Ramachandran et al (2025) [<xref ref-type="bibr" rid="ref72">72</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Jo et al (2024) [<xref ref-type="bibr" rid="ref58">58</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Fallah et al (2025) [<xref ref-type="bibr" rid="ref59">59</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Li et al (2023) [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td></tr><tr><td align="left" valign="top">Waranski et al (2024) [<xref ref-type="bibr" rid="ref73">73</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Ni et al (2022) [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Liu et al (2026) [<xref ref-type="bibr" rid="ref44">44</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Bruggmann et al (2021) [<xref ref-type="bibr" rid="ref60">60</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Zhang et al (2025) [<xref ref-type="bibr" rid="ref45">45</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Patterson et al (2023) [<xref ref-type="bibr" rid="ref61">61</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Batalik et al (2020) [<xref ref-type="bibr" rid="ref62">62</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td></tr><tr><td align="left" valign="top">Dalli Peydr&#x00F3; et al (2022) [<xref ref-type="bibr" rid="ref63">63</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Bravo-Escobar et al (2017) [<xref ref-type="bibr" rid="ref64">64</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Widmer et al (2015) [<xref ref-type="bibr" rid="ref74">74</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Johnston et al (2016) [<xref ref-type="bibr" rid="ref65">65</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Kumar et al (2024) [<xref ref-type="bibr" rid="ref66">66</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Bretschneider et al (2024) [<xref ref-type="bibr" rid="ref67">67</xref>]</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Herring et al (2021) [<xref ref-type="bibr" rid="ref68">68</xref>]</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Li et al (2025) [<xref ref-type="bibr" rid="ref46">46</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Khikmatova et al (2025) [<xref ref-type="bibr" rid="ref69">69</xref>]</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top">&#x2713;</td><td align="left" valign="top">&#x2713;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr></tbody></table></table-wrap></sec><sec id="s3-4"><title>The Form of DHT in CR for Patients With CHD</title><p>The 43 studies included in this research demonstrate that DHTs exhibit significant diversity in their application within CR for patients with CHD. These technologies can be categorized into 3 core groups (<xref ref-type="table" rid="table3">Table 3</xref>): digital health tools, real-time remote support, and asynchronous communication. Among these, digital health tools represent the most prevalent intervention form, enabling patients with CHD to undertake self-management and monitoring primarily through devices or software. This includes apps (28/43, 65.1%) [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>], wearable devices (22/43, 51.1%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>], websites (9/43, 20.9%) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref74">74</xref>], and social media platforms (6/43, 13.9%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. Wearable devices encompass smartwatches, heart rate monitors, fitness trackers, and pedometers, primarily used for real-time monitoring of physiological indicators and exercise data. Real-time remote support involves direct interpersonal interaction via voice or video, covering telephone (15/43, 34.8%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>], remote counseling sessions, and group meetings. Asynchronous communication delivers reminders, education, and support through non&#x2013;real-time information exchange, chiefly via SMS text messaging (10/43, 23.2%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] and email. As shown in <xref ref-type="table" rid="table2">Table 2</xref>, multitechnology combined interventions have become the predominant model. A substantial 83.7% (36/43) of studies used combinations of 2 or more digital technologies, such as &#x201C;app+wearable device&#x201D; [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>] and &#x201C;social media platform+wearable device+telephone&#x201D; [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref36">36</xref>]. Some studies further integrated digital technologies with traditional rehabilitation methods like face-to-face guidance and offline education, forming blended online-offline rehabilitation models. This landscape not only reflects varying levels of technological support, from standalone tools to interpersonal interactions, but also signals the trend toward systematized and diversified digital CR.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>A total of 3 categories and 10 specific forms of digital health technology application in cardiac rehabilitation interventions.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Type</td><td align="left" valign="bottom">Core functionality</td><td align="left" valign="bottom">Content</td></tr></thead><tbody><tr><td align="left" valign="top">Digital health tools</td><td align="left" valign="top">Provide patients with tools for independent health management through a technology platform, emphasizing self-monitoring and personalized interaction.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Wearable devices</p></list-item><list-item><p>App</p></list-item><list-item><p>Website</p></list-item><list-item><p>Digital video</p></list-item><list-item><p>Social media platform</p></list-item></list></td></tr><tr><td align="left" valign="top">Real-time remote support</td><td align="left" valign="top">Provides real-time, person-to-person professional support or peer interaction through synchronous communication technology, with high interactivity.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Telephone</p></list-item><list-item><p>Group meeting</p></list-item><list-item><p>Remote counseling sessions</p></list-item></list></td></tr><tr><td align="left" valign="top">Asynchronous communication</td><td align="left" valign="top">Reminders, education, and support are provided through non&#x2013;real-time information transmission methods, which are flexible and not restricted by time or space.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Email</p></list-item><list-item><p>SMS text messaging</p></list-item></list></td></tr></tbody></table></table-wrap></sec><sec id="s3-5"><title>The Objectives of DHT in CR for Patients With CHD</title><p>From the perspective of intervention objectives, the application of DHTs in CHD rehabilitation exhibits distinct functional stratification. Health education (36/43, 83.7%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>-<xref ref-type="bibr" rid="ref74">74</xref>], data monitor (34/43, 79.1%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref74">74</xref>], and reminders and alerts (18/43, 41.9%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref71">71</xref>-<xref ref-type="bibr" rid="ref73">73</xref>] form the core functional layer, each accounting for over 80% of applications in the included studies. Feedback, goal setting, and personalized interventions constitute the secondary core functional layer, with application rates ranging between 50% and 70%. Additionally, some studies integrated distinctive features such as gamification, reward mechanisms, social support, emotional support or counseling, and remotely adjust prescription to address patients&#x2019; diverse rehabilitation needs. Building upon this, this study systematically categorized the intervention objectives across 43 publications, identifying 15 specific types grouped into 4 major categories: first, motivation and guidance, encompassing goal setting, feedback, reward mechanisms, gamification, and reminders and alerts, aimed at incentivizing patients with CHD to complete rehabilitation behaviors and enhance adherence; second, foundation of knowledge and skills, centered on health education and training courses to help patients with CHD build the knowledge base and self-management capabilities required for disease management; third, monitoring and security, including data monitoring, real-time monitoring, and ensuring safety for physiological indicator tracking, risk assessment, and safety protection during rehabilitation; and fourth, social and group dynamics, leveraging peer effects and social support mechanisms to use social relationships and group interactions to promote patient adherence to rehabilitation behaviors. The specific composition is detailed in <xref ref-type="table" rid="table4">Table 4</xref>. As shown in <xref ref-type="table" rid="table2">Table 2</xref>, health education emerged most frequently, underscoring the central role of knowledge transfer in contemporary digital rehabilitation practice. Notably, the vast majority of studies adopted multipurpose integrated intervention strategies, organically combining educational, motivational, monitoring, and social support functions rather than relying on single technological approaches. It is precisely this composite application model that has transformed DHTs from fragmented tools into systematic rehabilitation support systems, significantly enhancing the holistic nature and continuity of rehabilitation interventions.</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>A total of 4 key intervention objectives and 15 specific types of digital health technologies in cardiac rehabilitation for individuals with coronary heart disease.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Type</td><td align="left" valign="bottom">Core objective</td><td align="left" valign="bottom">Content</td></tr></thead><tbody><tr><td align="left" valign="top">Motivation and guidance</td><td align="left" valign="top">Motivate patients and guide them to complete specific behaviors.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Goal setting</p></list-item><list-item><p>Feedback</p></list-item><list-item><p>Reward mechanism</p></list-item><list-item><p>Gamification</p></list-item><list-item><p>Alerts and reminders</p></list-item><list-item><p>Personalization</p></list-item></list></td></tr><tr><td align="left" valign="top">Foundation of knowledge and skills</td><td align="left" valign="top">Provide necessary information and cultivate patients&#x2019; self-management skills.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Health education</p></list-item><list-item><p>Training courses</p></list-item></list></td></tr><tr><td align="left" valign="top">Monitoring and security</td><td align="left" valign="top">Track data, assess risks, and provide a safety net.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Data monitor</p></list-item><list-item><p>Real-time monitoring</p></list-item><list-item><p>Ensuring safety</p></list-item><list-item><p>Remotely adjust prescription</p></list-item></list></td></tr><tr><td align="left" valign="top">Social and group dynamics</td><td align="left" valign="top">Using social relationships and group dynamics to promote patient adherence and change.</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Peer effect</p></list-item><list-item><p>Social support</p></list-item><list-item><p>Emotional support or counseling</p></list-item></list></td></tr></tbody></table></table-wrap></sec><sec id="s3-6"><title>Evaluation Criteria of DHT in CR for Patients With CHD</title><p>The outcome measures included in the study encompass 5 major categories: clinical physiological indicators, rehabilitation behavioral indicators, patient-reported outcomes, rehabilitation service use rates, and technical feasibility. Clinical physiological indicators include peak oxygen uptake, 6-minute walk distance, and blood pressure. Rehabilitation behavioral indicators include exercise adherence, medication adherence, physical activity levels, dietary adherence, and sedentary time. Patient-reported outcomes encompassed quality of life, self-efficacy, anxiety and depression levels, disease knowledge, and rehabilitation satisfaction. Rehabilitation service use metrics included rehabilitation acceptance rate, adherence rate, completion rate, readmission rate, and emergency department visit rate. Technical feasibility referred to patient satisfaction with the DHT used.</p></sec><sec id="s3-7"><title>Clinical Efficacy and Physiological Indicators</title><p>Clinical efficacy and physiological indicators constitute the core dimensions for evaluating the effectiveness of DHTs, with over 60% of studies incorporating them as primary outcomes. These encompass 3 specific levels: cardiopulmonary function, physical capacity and strength, and clinical end-point events. Cardiopulmonary function stands as the most critical indicator, with peak oxygen uptake [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] and 6-minute walk distance [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] being the most widely applied measures. Combining remote monitoring, wearable devices, and online guidance can effectively improve patients&#x2019; cardiopulmonary function, as measured by peak oxygen uptake and 6-minute walk distance [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. Physical function and strength serve as supplementary dimensions, encompassing muscle endurance and overall physical capacity. Dalli Peydr&#x00F3; et al [<xref ref-type="bibr" rid="ref63">63</xref>] confirmed that remote rehabilitation improves patients&#x2019; physical activity capabilities. Regarding clinical end points, over 20 studies evaluated blood pressure, lipid profiles, N-terminal pro-brain natriuretic peptide, and left ventricular ejection fraction. Li et al [<xref ref-type="bibr" rid="ref37">37</xref>] found that app-based interventions increased lipid control rates; however, no consistent conclusions have emerged regarding long-term outcomes such as readmission rates and major adverse cardiovascular events. For instance, Krzowski et al [<xref ref-type="bibr" rid="ref47">47</xref>] did not demonstrate a significant advantage of digital interventions in reducing readmission rates, suggesting that further research is needed to substantiate long-term efficacy.</p></sec><sec id="s3-8"><title>Health Behavior and Lifestyle</title><p>Health behaviors and lifestyle constitute core factors in improving the long-term prognosis of patients with CHD, with over half of the studies incorporating them into evaluations. These are categorized into 2 dimensions: exercise behavior and daily lifestyle. Regarding exercise behavior, key indicators include physical activity levels, exercise adherence, number of exercise days, and duration. Xu et al [<xref ref-type="bibr" rid="ref41">41</xref>] demonstrated in a telerehabilitation study based on the Self-Monitoring, Coaching, e-Health, Interactive Feedback, and Personalization model that the intervention group exhibited significantly superior exercise adherence and duration compared to the control group. Varnfield et al [<xref ref-type="bibr" rid="ref48">48</xref>] confirmed that smartphone-based home rehabilitation effectively enhances physical activity levels in patients with postmyocardial infarction. Optimization of daily lifestyle habits has also garnered significant attention, encompassing indicators such as medication adherence, dietary compliance, fruit and vegetable intake, sedentary time, and smoking cessation behavior. Interventions incorporating digital tools have shown positive effects on dietary adherence, sedentary time, and smoking cessation [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]. DHTs effectively enhance patient motivation for behavioral change through personalized reminders, real-time feedback, and adaptive goal-setting, thereby promoting the sustained maintenance of healthy behaviors.</p></sec><sec id="s3-9"><title>Patient-Reported Outcomes and Cognitive Function</title><p>Patient-reported outcomes and cognitive-related indicators constitute crucial dimensions for evaluating the humanistic value of DHTs. A total of 34 such indicators were incorporated into the studies as assessment criteria, encompassing domains such as quality of life, social cognition and support, disease knowledge, and psychological state [<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. Quality of life emerged as the most frequently assessed outcome, with multiple studies using scales such as the Short Form 36 Health Survey, EQ-5D, and Heart Disease-Specific Quality of Life Questionnaire. Dodson et al [<xref ref-type="bibr" rid="ref53">53</xref>] demonstrated positive trends in mobile health interventions improving health status among older patients, while Hisam et al [<xref ref-type="bibr" rid="ref54">54</xref>] found that mobile health interventions significantly enhanced quality of life in patients with postacute coronary syndrome. Regarding knowledge and self-management capabilities, health education emerged as the most prevalent intervention objective. Its efficacy was evaluated through indicators such as cardiovascular risk factor knowledge and self-management competence. Chan et al [<xref ref-type="bibr" rid="ref34">34</xref>] confirmed that 0-time exercise interventions can enhance patients&#x2019; exercise self-efficacy. In the domain of social cognition and support, Duan et al [<xref ref-type="bibr" rid="ref35">35</xref>] incorporated social cognitive outcomes into its evaluation. DHTs effectively enhance patient cognition through personalized education and interactive feedback, providing crucial support for the long-term maintenance of rehabilitation outcomes.</p></sec><sec id="s3-10"><title>Program Participation and Adherence</title><p>Participation rates and adherence in CR are core indicators for assessing the real-world feasibility of DHTs. These encompass rehabilitation program participation rates, adherence rates, completion rates, alongside patient satisfaction and perceived acceptability. Varnfield et al [<xref ref-type="bibr" rid="ref48">48</xref>] found that smartphone-based home rehabilitation significantly improved rehabilitation uptake, adherence, and completion rates among patients with postmyocardial infarction compared to conventional rehabilitation, providing robust evidence for digital technologies enhancing rehabilitation engagement. Ramachandran et al [<xref ref-type="bibr" rid="ref72">72</xref>] further validated the advantages of home-based remote rehabilitation in improving rehabilitation use rates. Patient satisfaction, acceptability, and perceived ease of use of the technology are also crucial evaluation components. Studies by Bernal-Jim&#x00E9;nez et al [<xref ref-type="bibr" rid="ref51">51</xref>] and Cruz-Cobo et al [<xref ref-type="bibr" rid="ref50">50</xref>] both incorporated application satisfaction into their evaluation frameworks. Multiple studies indicate that DHTs, through their accessibility, convenience, and interactive features, significantly reduce participation barriers such as geographical constraints and time conflicts, laying a solid foundation for improving rehabilitation participation rates and adherence.</p></sec><sec id="s3-11"><title>Technical Feasibility, Safety, and Use</title><p>Against the backdrop of rapid advancements in DHTs, evaluating their feasibility, safety, and impact on health care service use is particularly crucial. Assessments of technical feasibility encompass device operational stability, data collection integrity, and user-friendliness. Wohlfahrt et al [<xref ref-type="bibr" rid="ref71">71</xref>] demonstrated in their study that smart device step tracking exhibits good feasibility and compliance among patients with postmyocardial infarction. Safety assessments involve adverse event monitoring, data privacy protection, and risk alert mechanisms. Ma et al [<xref ref-type="bibr" rid="ref40">40</xref>] demonstrated in a long-term follow-up study that digital interventions did not increase the risk of major adverse cardiovascular events. Health care use metrics include readmission rates and emergency department visit rates. Widmer et al [<xref ref-type="bibr" rid="ref55">55</xref>] observed a downward trend in readmissions and emergency visits within the digital intervention group, though this did not reach statistical significance. Several studies have mentioned the need for cost-effectiveness analysis of digital rehabilitation, and preliminary explorations suggest that it may have potential economic advantages, but more empirical evidence is needed, though further evidence accumulation remains necessary.</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>In this study, we used a scoping review methodology to systematically evaluate the current application of DHTs in CR for patients with CHD. The research revealed its core characteristics, including diverse forms of technological application, multidimensional intervention objectives, and multilevel assessment indicators. It integrated 3 categories of technological application forms, 4 categories of intervention objectives, and 5 types of outcome assessment indicators. Findings indicate that DHTs have evolved from supplementary aids to systematic solutions, effectively overcoming the temporal and spatial constraints of traditional rehabilitation. This advance has significantly improved patient engagement in CR and treatment adherence in patients with CHD.</p></sec><sec id="s4-2"><title>Diversity and Integration of DHTs</title><p>Through this scoping review, we found that DHTs show obvious diversity and integration in the form of technology app, which can be divided into 3 main types: digital health tools, real-time remote support, and asynchronous communication. These encompass 10 specific formats including wearable devices, app, website, digital video, social media platform, telephone, group meeting, remote counseling sessions, email, and SMS text messaging. In this scoping review, we found that apps are the main intervention tool for digital CR, and wearable devices are key for real-time data monitoring; their combined application represents the most prevalent model.</p><p>From a technical support perspective, digital health tools are primarily oriented toward patient self-management and health monitoring. This aligns with the findings of van Olmen et al [<xref ref-type="bibr" rid="ref75">75</xref>], who concluded that digital health tools can effectively empower individuals to engage in self-management and advance the achievement of relevant health goals. Real-time remote support emphasizes direct interpersonal interaction between clinicians and patients, preserving the inherent humanistic care inherent in traditional health care [<xref ref-type="bibr" rid="ref76">76</xref>]. For instance, studies by Ryan et al [<xref ref-type="bibr" rid="ref77">77</xref>] integrated empathy and care into remote interactions, revealing no significant difference in perceived humanistic care compared to in-person consultations. Asynchronous communication, leveraging flexible information delivery, provides patients with continuous health reminders and educational support [<xref ref-type="bibr" rid="ref15">15</xref>].</p><p>These 3 complementary levels synergistically construct a multitiered, multidimensional, and comprehensive rehabilitation support system spanning patient self-management to real-time clinician-patient interaction. This provides a viable pathway for developing personalized, multimodal CR models. Notably, some studies further integrate offline face-to-face guidance, forming a blended rehabilitation model combining online and offline approaches [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. This aligns with findings from Thomas et al [<xref ref-type="bibr" rid="ref78">78</xref>], confirming that a comprehensive digital technology app significantly enhances the individualized adaptability of CR. Compared to traditional rehabilitation methods, this blended model partially addresses limitations such as relatively monotonous formats and insufficient consideration of individual differences [<xref ref-type="bibr" rid="ref79">79</xref>].</p></sec><sec id="s4-3"><title>The Multifaceted Application Objectives of DHTs</title><p>In this scoping review, we found that DHTs exhibit multifaceted features in terms of intervention goals, which can be divided into 4 main dimensions: motivation and guidance, foundation of knowledge and skills, monitoring and security, and social and group dynamics. A total of 15 specific objectives have been identified. Health education, data monitoring, and reminders and alerts form the core layer; feedback, goal setting, and personalized interventions constitute the secondary layer; while some studies incorporate distinctive features such as gamification, rewards, and social support.</p><p>All interventions integrate multidimensional objectives, with health education appearing most frequently, highlighting the central role of knowledge transfer [<xref ref-type="bibr" rid="ref80">80</xref>]. Features like gamification and social support effectively address patient issues such as lack of motivation and difficulty sustaining behavior [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. This aligns with the WHO Global Digital Health Strategy&#x2019;s advocacy for &#x201C;patient-centered approaches to achieve sustainable behavioral change&#x201D; [<xref ref-type="bibr" rid="ref17">17</xref>]. This multidimensional goal integration enables DHTs to systematically tackle key barriers to participation in traditional CR [<xref ref-type="bibr" rid="ref78">78</xref>]. Knowledge gaps can be addressed through health education, motivation deficits remedied by gamified incentives, and sustained support ensured via social interaction [<xref ref-type="bibr" rid="ref81">81</xref>]. It is precisely this composite application model that has evolved DHTs from fragmented tools into systematic rehabilitation support systems. This significantly enhances the comprehensiveness and continuity of rehabilitation interventions, providing a crucial pathway for advancing patients with CHD understanding of CR and enabling precision-targeted interventions [<xref ref-type="bibr" rid="ref15">15</xref>].</p></sec><sec id="s4-4"><title>Effect Evaluation</title><p>Analysis of multidimensional assessment indicators across 43 included studies demonstrates that DHTs exhibit clear short-term intervention value for CR of patients with CHD. However, evidence for long-term clinical outcomes remains scarce, strongly aligning with the findings of positive short- to medium-term effects and insufficient long-term evidence.</p><p>Regarding clinical physiological indicators, DHTs significantly improve patients&#x2019; cardiopulmonary function and physical fitness levels, with statistically significant improvements in core metrics like peak oxygen uptake and 6-minute walk distance observed in intervention groups. They also positively influence blood pressure and lipid control, validating the effectiveness of real-time monitoring and personalized guidance in short-term physiological optimization [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. At the health behavior level, digital technologies significantly enhance rehabilitation adherence in areas like exercise, medication, and diet through mechanisms such as scheduled reminders and real-time feedback. They also correct unhealthy lifestyle habits like prolonged sitting, aligning with findings where health behaviors serve as core assessment dimensions [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]. Regarding patient-reported outcomes and rehabilitation service use, digital interventions effectively improve patients&#x2019; quality of life, disease awareness, and self-efficacy. They also significantly overcome temporal and spatial constraints, increasing rehabilitation participation and completion rates while alleviating barriers to traditional rehabilitation, consistent with outcome-related findings [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref72">72</xref>].</p><p>However, existing studies have not reached a unified conclusion regarding the assessment of long-term clinical outcomes. While some studies observed a downward trend in readmission rates, they failed to demonstrate statistical significance in reducing major adverse cardiovascular events or long-term mortality [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. This is closely related to the limited sample sizes and short follow-up periods in most studies, as well as the significant heterogeneity in intervention designs and the lack of systematic long-term rehabilitation management systems. Research on the long-term cost-effectiveness and sustainability of these interventions is also scarce, necessitating further exploration [<xref ref-type="bibr" rid="ref82">82</xref>].</p></sec><sec id="s4-5"><title>Advantages and Challenges of DHT</title><p>The most significant advantage of DHTs lies in their ability to effectively overcome geographical constraints and economic barriers, substantially enhancing the accessibility of CR and patient participation rates [<xref ref-type="bibr" rid="ref21">21</xref>]. In this study, we found that by providing easily accessible, user-friendly, and highly interactive digital technologies, it is possible to significantly reduce structural barriers commonly encountered in traditional rehabilitation models, such as transport difficulties, time conflicts, and uneven resource distribution [<xref ref-type="bibr" rid="ref4">4</xref>]. Research by Varnfield et al [<xref ref-type="bibr" rid="ref48">48</xref>] confirmed that smartphone-based home rehabilitation significantly outperformed traditional rehabilitation in terms of uptake, adherence, and completion rates among patients with postmyocardial infarction. Ramachandran et al [<xref ref-type="bibr" rid="ref72">72</xref>] further validated the superiority of home-based remote rehabilitation in enhancing rehabilitation use rates. This finding provides a pathway to high-quality rehabilitation services for remote areas with scarce medical resources and for patients with CHD with limited mobility, positioning DHTs as a crucial strategic tool for bridging geographical disparities in health care resources and advancing equity in cardiovascular health services. However, the widespread adoption of digital technologies also presents a new challenge: the &#x201C;digital divide&#x201D; [<xref ref-type="bibr" rid="ref15">15</xref>]. Older adults, low-income groups, and patients with lower educational attainment may encounter significant difficulties in operating digital devices, using apps, or accessing information [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>].</p><p>Therefore, advancing DHT must prioritize equity and inclusivity as core principles [<xref ref-type="bibr" rid="ref17">17</xref>]. Simplified interfaces and voice-assisted features tailored for older people and low-skilled users should be developed, alongside personalized, face-to-face training in digital technology use [<xref ref-type="bibr" rid="ref85">85</xref>]. Exploring device subsidies or digital equipment loan schemes for vulnerable groups is essential to overcome digital barriers and encourage active participation in digital CR [<xref ref-type="bibr" rid="ref83">83</xref>]. Furthermore, key challenges for scaling DHTs include technical feasibility, data security and privacy protection, sustainable cost-effectiveness, and seamless integration of digital interventions into existing clinical workflows [<xref ref-type="bibr" rid="ref15">15</xref>]. Currently, while some studies have begun examining implementation-level indicators for DHTs, such as the feasibility of smart device monitoring and remote rehabilitation, overall evidence remains limited. Greater practical research and systematic evaluation are urgently needed to advance the standardized application and long-term development of digital CR models [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref86">86</xref>].</p></sec><sec id="s4-6"><title>Limitations</title><p>Although we systematically reviewed the current application of DHTs in CR for patients with CHD through a scoping review methodology, several limitations remain. First, regarding literature sources, we only included peer-reviewed empirical research published in English. While this approach helps ensure the quality of included studies, it may overlook important literature published in other languages and relevant gray literature, thereby affecting the comprehensiveness of the study conclusions. Second, significant methodological heterogeneity among the included studies limited the integration and comparability of results. We varied significantly in intervention design, technology combinations, intervention duration, use frequency, participant characteristics, selected outcome measures, and follow-up periods. Furthermore, most studies featured small sample sizes and short follow-up durations, lacking comprehensive assessments of long-term clinical outcomes, cost-effectiveness, intervention sustainability, and impacts on health equity. This limits a thorough evaluation of the long-term value of DHTs.</p></sec><sec id="s4-7"><title>Conclusions</title><p>In this study, we used a scoping review methodology to systematically examine the current application and practical value of DHTs in CR for patients with CHD. Findings confirm that DHTs effectively improve patients&#x2019; short-term physiological function and optimize health behaviors. Simultaneously, they overcome limitations in traditional CR regarding spatial-temporal constraints and health care resource allocation, significantly enhancing patient engagement and adherence to rehabilitation programs. In clinical practice, health care providers can integrate multiple DHTs to develop personalized rehabilitation plans tailored to individual characteristics such as patient age, digital literacy, and disease severity, thereby enhancing the precision and adaptability of CR. Future research should prioritize large-scale, multicenter, long-term follow-up randomized controlled trials to thoroughly investigate the impact of DHTs on long-term clinical outcomes for patients with CHD and explore potential mechanisms of action, such as long-term mortality and major adverse cardiovascular events. This will provide more robust evidence-based support for validating their long-term efficacy and advancing standardized clinical implementation.</p></sec></sec></body><back><ack><p>The authors wish to express their gratitude to the librarians who assisted in formulating the retrieval strategy, as well as to all scholars in relevant fields for their accumulated prior research. The authors did not use any artificial intelligence generation tool in the study.</p></ack><notes><sec><title>Funding</title><p>This work was supported by grants from 2025 Basic Scientific Research Projects of Colleges and Universities in Humanities and Social Sciences Category of Liaoning Provincial Department of Education (LJ112510162012); 2025 Nursing Discipline Research Projects of the Chinese Medical Association Publishing House (CMAPH-NRC2025011). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: XZ (lead), LL (supporting)</p><p>Data curation: XZ (lead), ZL (supporting), LL (supporting), JW (supporting)</p><p>Formal analysis: XZ (lead), JW (supporting), ZL (supporting)</p><p>Funding acquisition: LL (lead), JW (equal)</p><p>Investigation: XZ (lead), ZL (supporting), LL (supporting), JW (supporting)</p><p>Methodology: XZ (lead), LL (supporting)</p><p>Project administration: MZ (lead), YW (supporting), HL (supporting)</p><p>Resources: MZ (lead), YW (equal), HL (equal)</p><p>Supervision: LL (lead), HL (supporting), YW (supporting), MZ (supporting)</p><p>Writing&#x2014;original draft: XZ (lead), JW (supporting), YT (supporting)</p><p>Writing&#x2014;review and editing: XZ (lead), JW (supporting), YW (supporting), YT (supporting), LL (supporting), MZ (supporting), HL (supporting)</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">CHD</term><def><p>coronary heart disease</p></def></def-item><def-item><term id="abb2">CR</term><def><p>cardiac rehabilitation</p></def></def-item><def-item><term id="abb3">CVD</term><def><p>cardiovascular disease</p></def></def-item><def-item><term id="abb4">DHT</term><def><p>digital health technology</p></def></def-item><def-item><term id="abb5">PRISMA</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></def></def-item><def-item><term id="abb6">PRISMA-S</term><def><p>extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews</p></def></def-item><def-item><term id="abb7">PRISMA-ScR</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping 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