<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v28i1e105445</article-id><article-id pub-id-type="doi">10.2196/105445</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Digital Health Technologies for Mobility Recovery Among Intensive Care Unit Survivors: Scoping Review</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Yan</surname><given-names>Yuhang</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Zhu</surname><given-names>Jiayan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Peng</surname><given-names>Sining</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Qiu</surname><given-names>Jin</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Cheng</surname><given-names>Linghong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Ge</surname><given-names>Xiaohua</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><institution>School of Nursing, Shanghai Jiao Tong University</institution><addr-line>Shanghai</addr-line><country>China</country></aff><aff id="aff2"><institution>Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital</institution><addr-line>Shanghai</addr-line><country>China</country></aff><aff id="aff3"><institution>Department of Health Humanities Education, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine</institution><addr-line>No. 1665 Kongjiang Road, Yangpu District</addr-line><addr-line>Shanghai</addr-line><country>China</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Stone</surname><given-names>Alicia</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Rahman</surname><given-names>Arafat</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Ngan</surname><given-names>Chansokhon</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Xiaohua Ge, PhD, Department of Health Humanities Education, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Yangpu District, Shanghai, 200082, China, 86 13651633618; <email>gexiaohua@xinhuamed.com.cn</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>5</day><month>11</month><year>2026</year></pub-date><volume>28</volume><elocation-id>e105445</elocation-id><history><date date-type="received"><day>25</day><month>06</month><year>2026</year></date><date date-type="rev-recd"><day>01</day><month>10</month><year>2026</year></date><date date-type="accepted"><day>02</day><month>10</month><year>2026</year></date></history><copyright-statement>&#x00A9; Yuhang Yan, Jiayan Zhu, Sining Peng, Jin Qiu, Linghong Cheng, Xiaohua Ge. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 5.11.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2026/1/e105445"/><abstract><sec><title>Background</title><p>Mobility recovery after critical illness is a complex and multidimensional process. Digital health technologies have emerged as approaches for delivering rehabilitation, monitoring recovery, and facilitating self-management among intensive care unit (ICU) survivors. However, the extent to which current digital health approaches address the multidimensional nature of mobility recovery remains unclear.</p></sec><sec><title>Objective</title><p>This scoping review aimed to map the current evidence on digital health approaches supporting mobility recovery among ICU survivors and to examine the mobility domains, outcomes, feasibility, and acceptability associated with these approaches.</p></sec><sec sec-type="methods"><title>Methods</title><p>A scoping review was conducted following the Arksey and O&#x2019;Malley framework and was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library were searched for studies published from January 2016 to September 21, 2026. Studies involving adult ICU survivors that used digital health approaches to assess, monitor, support, or promote mobility recovery were included. Mobility outcomes were mapped to the International Classification of Functioning, Disability and Health domains of body functions and structures, activities, and participation. Clinical outcomes were synthesized separately from implementation and user experience outcomes.</p></sec><sec sec-type="results"><title>Results</title><p>Twenty-seven reports representing 24 unique parent studies were included. Digital health approaches comprised telemedicine, telerehabilitation, mobile health, wearable monitoring, virtual reality, robot-assisted rehabilitation, and digital recovery platforms. Telemedicine and telerehabilitation were the most frequently reported approaches, and exercise-based rehabilitation was the predominant intervention component. Mobility outcomes were heterogeneous and concentrated on body functions and structures and activity-level performance, particularly muscle strength, exercise capacity, and functional performance, whereas participation outcomes were less frequently represented. Controlled and comparative studies showed mixed between-group findings, with clinical benefits not consistently demonstrated across primary or mobility-related outcomes. In contrast, feasibility, adherence, usability, and acceptability were generally favorable when assessed, although technical difficulties and incomplete device-generated data were reported in some studies.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Digital health technologies offer diverse approaches to supporting mobility recovery after critical illness, but current evidence remains concentrated on physical function and activity-level outcomes, with limited attention to participation and long-term recovery. More rigorous and longitudinal studies using standardized, multidimensional mobility outcomes are needed to clarify clinical effectiveness and support sustainable implementation.</p></sec></abstract><kwd-group><kwd>digital health</kwd><kwd>intensive care units</kwd><kwd>survivors</kwd><kwd>critical illness</kwd><kwd>rehabilitation</kwd><kwd>telemedicine</kwd><kwd>mobility limitation</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Critical care has entered a survivorship era. Improvements in intensive care unit (ICU) survival have resulted in a growing population of ICU survivors experiencing post&#x2013;intensive care syndrome, including physical, cognitive, psychological, and social impairments [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref3">3</xref>]. Among these domains, mobility is clinically central, as it determines whether survivors can safely transfer, walk indoors and outdoors, climb stairs, engage in rehabilitation activities, return to work or caregiving roles, and re-engage in meaningful daily activities [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. Longitudinal studies among survivors of acute respiratory distress syndrome, sepsis, and other critical illnesses have consistently demonstrated persistent physical disability, reduced walking capacity, dependence in activities of daily living (ADLs), frailty, and poorer quality of life [<xref ref-type="bibr" rid="ref6">6</xref>-<xref ref-type="bibr" rid="ref8">8</xref>].</p><p>Mobility in ICU survivorship extends beyond ambulation and encompasses multiple dimensions of functioning [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. The World Health Organization&#x2019;s International Classification of Functioning, Disability and Health (ICF) provides a standardized framework for describing functioning across body functions and structures, activities, and participation, while recognizing the influence of contextual factors [<xref ref-type="bibr" rid="ref14">14</xref>]. Accordingly, mobility recovery after critical illness can be examined across these complementary domains. ICU survivor studies have used diverse measures, including the 6-minute walk test (6MWT), functional status score for the ICU [<xref ref-type="bibr" rid="ref9">9</xref>], de Morton Mobility Index [<xref ref-type="bibr" rid="ref15">15</xref>], short physical performance battery [<xref ref-type="bibr" rid="ref16">16</xref>], Barthel Index [<xref ref-type="bibr" rid="ref17">17</xref>] or Katz ADL [<xref ref-type="bibr" rid="ref18">18</xref>], frailty instruments [<xref ref-type="bibr" rid="ref19">19</xref>], handgrip or knee-extension dynamometry, ultrasound muscle thickness [<xref ref-type="bibr" rid="ref20">20</xref>], 36-Item Short Form Health Survey (SF-36) [<xref ref-type="bibr" rid="ref21">21</xref>], and qualitative accounts of meaningful activity.</p><p>Despite this multidimensional conceptualization, it remains unclear whether existing digital health technologies address mobility recovery across the ICF domains or continue to focus predominantly on physical capacity and performance. Identifying which domains are represented in current digital health research is, therefore, important for revealing evidence gaps and informing more comprehensive, person-centered rehabilitation strategies for ICU survivors.</p><p>Clinic-based assessments provide standardized snapshots, but they may not fully capture fluctuations in mobility and participation in everyday settings. Many ICU survivors experience fatigue, dyspnea, weakness, mood symptoms, transportation barriers, and fragmented services after discharge [<xref ref-type="bibr" rid="ref22">22</xref>-<xref ref-type="bibr" rid="ref24">24</xref>]. A survivor may perform adequately on a 6MWT in clinic yet remain sedentary at home; another may accumulate daily steps but continue to avoid stairs, community mobility, or social participation. These limitations highlight the need for approaches that can support and monitor recovery continuously in real-world settings.</p><p>Digital health technologies offer an opportunity. By leveraging smartphones, wearable devices, tele&#x2013;video sessions, app-based exercise programs, virtual reality (VR), and structured digital follow-up pathways [<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref29">29</xref>], these interventions can deliver remote rehabilitation, individualized exercise guidance, real-time feedback, motivational support, and structured progression [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref34">34</xref>]. However, the existing evidence remains fragmented, with many studies being small-scale, feasibility-oriented, and primarily focused on short-term physical outcomes.</p><p>A clear synthesis is therefore needed to determine which digital health technologies have been applied to mobility recovery among ICU survivors and which dimensions of functioning they address. Accordingly, this scoping review focuses on adult ICU survivors, encompasses digital health modalities across the post-ICU recovery trajectory, maps mobility outcomes to the ICF domains of body functions and structures, activities, and participation, and separately examines clinical outcomes, implementation feasibility, and user experience.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Design</title><p>This scoping review was conducted in accordance with the methodological framework proposed by Arksey and O&#x2019;Malley [<xref ref-type="bibr" rid="ref35">35</xref>], following their 5-stage approach. The review was reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines [<xref ref-type="bibr" rid="ref36">36</xref>]. The completed PRISMA-ScR checklist is provided in <xref ref-type="supplementary-material" rid="app2">Checklist 1</xref>. The study protocol and analysis plan were prospectively registered on the Open Science Framework [<xref ref-type="bibr" rid="ref37">37</xref>].</p></sec><sec id="s2-2"><title>Formulating the Research Question</title><p>This scoping review aimed to systematically map the current evidence on digital health technologies to support mobility recovery among ICU survivors. The review addressed the following research questions: (1) What digital health technologies have been applied to support mobility recovery among ICU survivors? (2) Which dimensions of mobility are targeted by these digital health technologies? (3) What evidence exists regarding mobility-related outcomes, implementation experiences, and user perspectives associated with these digital health technologies?</p></sec><sec id="s2-3"><title>Eligibility Criteria</title><p>The eligibility criteria were developed according to the PCC (population, concept, and context) framework [<xref ref-type="bibr" rid="ref38">38</xref>].</p><sec id="s2-3-1"><title>Inclusion Criteria</title><p>The inclusion criteria for the study are as follows:</p><list list-type="order"><list-item><p>Population: adults aged 18 years or older who survived critical illness following an ICU admission.</p></list-item><list-item><p>Concept: studies describing, evaluating, or implementing digital health technologies, programs, services, platforms, or interventions designed to support, assess, monitor, or promote mobility recovery after critical illness. Mobility was operationalized according to the ICF framework as outcomes related to body functions and structures, activities, and participation. Self-management and related behavioral or educational components were considered intervention or implementation characteristics rather than mobility domains.</p></list-item><list-item><p>Context: studies conducted across the ICU recovery trajectory, including transitions from hospital to home, outpatient follow-up, and community-based rehabilitation settings.</p></list-item></list></sec><sec id="s2-3-2"><title>Exclusion Criteria</title><p>Studies were excluded if the digital health technology was not relevant to mobility or functional recovery, if neither mobility-related nor relevant implementation or user experience outcomes were reported, or if the study did not include an identifiable group of adult ICU survivors. Nonempirical publications, including reviews, editorials, commentaries, conceptual papers, and study protocols, were also excluded. The full eligibility criteria are presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Eligibility criteria based on the population-concept-context framework.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Domain</td><td align="left" valign="bottom">Inclusion</td><td align="left" valign="bottom">Exclusion</td></tr></thead><tbody><tr><td align="left" valign="top">Population</td><td align="left" valign="top">Adults (&#x2265;18 y) who survived critical illness following an ICU<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> admission, including individuals transitioning from the ICU to hospital wards and those undergoing postdischarge recovery; studies of mixed populations were eligible if adult ICU survivors could be identified within the study population</td><td align="left" valign="top">Pediatric or neonatal populations; studies that did not include an identifiable group of adult ICU survivors</td></tr><tr><td align="left" valign="top">Concept</td><td align="left" valign="top">Digital health technologies, programs, services, platforms, or interventions that explicitly supported, assessed, monitored, or promoted mobility-related recovery or physical rehabilitation in populations including adult ICU survivors; eligible technologies included mobile apps, websites, wearable devices, telephones, video consultations, virtual reality, digital recovery platforms, and other digitally enabled approaches</td><td align="left" valign="top">Digital technologies used solely for assessment or monitoring without a clear relevance to mobility recovery; interventions delivered exclusively during ICU admission; nondigital rehabilitation technologies</td></tr><tr><td align="left" valign="top">Context</td><td align="left" valign="top">Any setting across the ICU recovery trajectory, including hospital wards, outpatient clinics, home-based settings, and community rehabilitation following ICU discharge</td><td align="left" valign="top">Settings unrelated to recovery after critical illness; pediatric or neonatal ICUs</td></tr><tr><td align="left" valign="top">Outcomes</td><td align="left" valign="top">Mobility-related outcomes included body functions and structures, activities, and participation; implementation and user experience outcomes included feasibility, adherence, usability, acceptability, satisfaction, self-management support, self-efficacy, engagement, and perceived barriers or facilitators</td><td align="left" valign="top">Studies reporting neither mobility-related outcomes nor relevant implementation or user experience outcomes; studies reporting only mortality or unrelated outcomes</td></tr><tr><td align="left" valign="top">Study design</td><td align="left" valign="top">All primary empirical study designs, including randomized controlled trials, nonrandomized studies, feasibility and pilot studies, observational studies, mixed methods studies, qualitative studies, case reports, and empirical innovation reports</td><td align="left" valign="top">Study protocols, reviews, editorials, conference abstracts, commentaries, conceptual papers, and other nonempirical publications</td></tr><tr><td align="left" valign="top">Publication</td><td align="left" valign="top">Peer-reviewed full-text papers published in English from January 2016 onward</td><td align="left" valign="top">Publications before January 2016, non-English publications, or papers without full-text availability</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>ICU: intensive care unit.</p></fn></table-wrap-foot></table-wrap></sec></sec><sec id="s2-4"><title>Search Strategy</title><sec id="s2-4-1"><title>Information Sources, Search Dates, and Limits</title><p>We systematically searched PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library for records published from January 1, 2016, through June 2026. To capture newly published studies, the searches were updated in all 5 databases on September 21, 2026, which was the final search date. No language, study design, or publication-type filters were applied during the database searches; all eligibility restrictions were applied during study selection.</p></sec><sec id="s2-4-2"><title>Search Terms and Search Combinations</title><p>The search strategy was developed in consultation with a medical librarian and informed by the population, concept, and context framework. Controlled vocabulary and free-text terms were used to represent three concepts: (1) ICU survivors and critical illness, (2) digital health technologies, and (3) mobility-related recovery. Synonymous terms within each concept were combined using OR, and the 3 concept blocks were combined using AND. The NOT operator was not used. Quotation marks were used for multiword phrases, and truncation symbols were applied where supported by the database.</p><p>The complete database-specific search strategies, including controlled vocabulary, keywords, field tags, Boolean operators, phrase searching, truncation, date limits, final search dates, and numbers of records retrieved, are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p></sec><sec id="s2-4-3"><title>Study Selection</title><p>All retrieved records were imported into EndNote for the removal of duplicates. Records identified through the updated searches were added to the same reference library and deduplicated against records retrieved previously. Two reviewers independently screened titles and abstracts against predefined eligibility criteria and subsequently assessed potentially eligible full-text papers. Disagreements were resolved through discussion or consultation with a third reviewer. The updated study-selection process, including records identified through the final search update, was documented using a PRISMA flow diagram.</p></sec><sec id="s2-4-4"><title>Data Charting</title><p>Data were independently charted by 2 reviewers (YY and JZ) using a standardized Microsoft Excel form. Discrepancies were resolved through discussion or consultation with a third reviewer (SP). The charted information included author, publication year, country, study design, participant characteristics, digital health technology, intervention characteristics, mobility-related outcomes, statistical or analytical approach, reported procedures for handling home-generated digital or device data, where applicable, and principal findings.</p><p>Mobility-related outcomes were classified according to the ICF framework [<xref ref-type="bibr" rid="ref14">14</xref>] into body functions and structures, activities, and participation. Outcomes were coded at the outcome-measure level; therefore, a study could contribute to more than one ICF domain when distinct outcomes represented different domains. Individual outcome measures were assigned to the domain they most directly represented and were not double-counted across domains. Self-management, goal setting, education, symptom monitoring, and engagement were treated as intervention- or implementation-related components rather than mobility domains.</p><p>For studies with a comparator, details of the comparator, primary and secondary outcomes as defined by the original study authors, assessment time points, between-group findings, and within-group changes were extracted where available. Implementation and user-experience outcomes, including feasibility, retention, adherence, intervention completion, safety, usability, acceptability, satisfaction, and perceived barriers or facilitators, were charted separately from clinical mobility outcomes.</p><p>Theoretical frameworks were extracted only when a named theory, model, or framework was explicitly reported as informing intervention design, implementation, or analysis. Frameworks were recorded as described by the original authors and were not inferred when no explicit theoretical basis was reported.</p></sec><sec id="s2-4-5"><title>Data Synthesis</title><p>Because of heterogeneity in study designs, interventions, and outcome measures, data were synthesized descriptively. Digital health technologies were classified according to their predominant function and delivery mode into 7 categories: telemedicine, telerehabilitation, mobile health, wearable monitoring, VR, robot-assisted rehabilitation, and digital recovery platforms. Each report was assigned to one primary technology category based on the predominant digital delivery mechanism; multicomponent interventions were classified according to the component through which the principal rehabilitation or recovery support was delivered.</p><p>Mobility-related outcomes were synthesized according to the ICF domains of body functions and structures, activities, and participation. A report could contribute to more than one ICF domain when it included distinct outcome measures representing different domains. Clinical outcomes were synthesized separately from implementation and user experience outcomes. In comparative studies, primary outcomes and between-group findings were prioritized; within-group changes were not interpreted as evidence of intervention effectiveness in the absence of a corresponding between-group effect. In noncomparative studies, changes over time were described without inferring effectiveness.</p><p>Studies involving mixed populations were retained if adult ICU survivors were identifiable, even if outcomes for the ICU subgroup were not reported separately. Intervention characteristics and reported outcomes were charted as reported, and findings from the full mixed population were identified as such. These studies contributed to mapping technology use, outcome measures, and implementation or user experience evidence. Findings available only for the mixed population were not interpreted as ICU-specific estimates of clinical effectiveness.</p><p>Reports arising from the same parent study were linked during synthesis and retained when they contributed distinct evidence. Each parent study was counted once when determining the number of unique studies. No formal methodological quality or risk-of-bias appraisal was conducted because the purpose of this scoping review was to map the breadth, characteristics, and gaps of the available evidence rather than to assess the certainty of intervention effects.</p></sec></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Study Selection</title><p>The updated database searches identified 2557 records. After the removal of 1291 duplicates, 1266 records underwent title and abstract screening, of which 906 were excluded. Full texts were sought for 360 reports; 5 could not be retrieved, leaving 355 reports for eligibility assessment. Of these, 328 were excluded because of an ineligible study design (n=81), an ineligible population (n=85), the absence of an eligible digital health intervention (n=64), or the absence of a mobility-related outcome (n=98). Ultimately, 27 reports representing 24 unique parent studies were included in the review. The study selection process is presented in the PRISMA flow diagram (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart presenting the search outcomes and study selection process.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v28i1e105445_fig01.png"/></fig></sec><sec id="s3-2"><title>Study Characteristics</title><p>The review included 27 reports representing 24 unique parent studies, comprising 11 randomized trial reports [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref49">49</xref>], 9 nonrandomized quantitative reports [<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref58">58</xref>], 3 qualitative reports [<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref61">61</xref>], 2 case reports [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], 1 innovation report [<xref ref-type="bibr" rid="ref64">64</xref>], and 1 multiple methods report [<xref ref-type="bibr" rid="ref65">65</xref>]. Reports arising from the same parent study were linked and retained when they contributed distinct evidence; each parent study was counted once in the total number of unique studies. The 3 pairs of linked reports were O&#x2019;Neill et al [<xref ref-type="bibr" rid="ref44">44</xref>] and Ghiglieri et al [<xref ref-type="bibr" rid="ref61">61</xref>], Kovaleva et al [<xref ref-type="bibr" rid="ref59">59</xref>] and Boehm et al [<xref ref-type="bibr" rid="ref49">49</xref>], and Rose et al [<xref ref-type="bibr" rid="ref64">64</xref>] and Apps et al [<xref ref-type="bibr" rid="ref65">65</xref>].</p><p>The studies were conducted across diverse geographical settings and included survivors of COVID-19&#x2013;related critical illness [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], acute respiratory failure [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>], sepsis and/or acute respiratory distress syndrome [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>], prolonged mechanical ventilation [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], and broader post-ICU populations [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], as well as a survivor of severe burn injury requiring prolonged critical care [<xref ref-type="bibr" rid="ref63">63</xref>]. Participant characteristics and age were reported heterogeneously across studies. Basic study characteristics are summarized in <xref ref-type="table" rid="table2">Table 2</xref>, while detailed information on the study populations, digital health technologies, intervention components, duration, delivery format, providers, settings, and mobility-related outcomes is provided in Table S1 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Characteristics of included study reports.<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study</td><td align="left" valign="bottom">Country</td><td align="left" valign="bottom">Study design</td><td align="left" valign="bottom">Sample size</td><td align="left" valign="bottom">Age, y</td></tr></thead><tbody><tr><td align="left" valign="top">de Vries et al [<xref ref-type="bibr" rid="ref50">50</xref>], 2025</td><td align="left" valign="top">Netherlands</td><td align="left" valign="top">Feasibility study</td><td align="left" valign="top">n=10</td><td align="left" valign="top">Median 71 (IQR 63-79) [<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref80">80</xref>]</td></tr><tr><td align="left" valign="top">Balakrishnan et al [<xref ref-type="bibr" rid="ref39">39</xref>], 2023</td><td align="left" valign="top">United States</td><td align="left" valign="top">Exploratory randomized controlled trial</td><td align="left" valign="top">I<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup>=20; C<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup>=20</td><td align="left" valign="top">Mean (SD) for I: 47.0 (13.9); C: 50.2 (11.5)</td></tr><tr><td align="left" valign="top">Capin et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2022</td><td align="left" valign="top">United States</td><td align="left" valign="top">Pilot randomized feasibility study</td><td align="left" valign="top">I=29; C=15</td><td align="left" valign="top">Mean (SD) for I: 52.0 (10.0); C: 53.0 (10.0)</td></tr><tr><td align="left" valign="top">&#x015E;ahin et al [<xref ref-type="bibr" rid="ref41">41</xref>], 2023</td><td align="left" valign="top">T&#x00FC;rkiye</td><td align="left" valign="top">Randomized controlled trial</td><td align="left" valign="top">I=21; C=21</td><td align="left" valign="top">Mean (SD) for I: 57.7 (8.4); C: 63.7 (7.9)</td></tr><tr><td align="left" valign="top">Khan et al [<xref ref-type="bibr" rid="ref42">42</xref>], 2024</td><td align="left" valign="top">United States</td><td align="left" valign="top">Randomized controlled trial</td><td align="left" valign="top">I=233; C=233</td><td align="left" valign="top">Mean (SD) for I: 55.2 (14.3); C: 56.9 (14.4)</td></tr><tr><td align="left" valign="top">Trzmiel et al [<xref ref-type="bibr" rid="ref43">43</xref>], 2023</td><td align="left" valign="top">Netherlands</td><td align="left" valign="top">Randomized controlled trial</td><td align="left" valign="top">I=42; C=39</td><td align="left" valign="top">Mean (SD) for I: 67.4 (8.5); C: 64.9 (11.7)</td></tr><tr><td align="left" valign="top">O&#x2019;Neill et al [<xref ref-type="bibr" rid="ref44">44</xref>], 2026</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Pragmatic multicenter randomized clinical trial</td><td align="left" valign="top">I=231; C=198</td><td align="left" valign="top">Mean (SD) for I: 55.0 (14.0); C: 55.0 (13.8)</td></tr><tr><td align="left" valign="top">Mayer et al [<xref ref-type="bibr" rid="ref51">51</xref>], 2021</td><td align="left" valign="top">United States</td><td align="left" valign="top">Pragmatic pre-post comparative study</td><td align="left" valign="top">I=22; C=10</td><td align="left" valign="top">Median for I: 56 [<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref62">62</xref>]; C: 55 [<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]</td></tr><tr><td align="left" valign="top">Carpallo-Porcar et al [<xref ref-type="bibr" rid="ref45">45</xref>], 2025</td><td align="left" valign="top">Spain</td><td align="left" valign="top">Pilot randomized controlled trial</td><td align="left" valign="top">I=17; C=18</td><td align="left" valign="top">Mean (SD) for I: 58.0 (2.0); C: 59.0 (9.0)</td></tr><tr><td align="left" valign="top">Howroyd et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2023</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Service evaluation study</td><td align="left" valign="top">n=28</td><td align="left" valign="top">Mean (SD) for 54.0 (11.0)</td></tr><tr><td align="left" valign="top">Hunter et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2022</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Multicenter observational study</td><td align="left" valign="top">n=50</td><td align="left" valign="top">Median for MDT<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup> site: mean 61 (range 49-73); Control site: mean 57 (range 35-77)</td></tr><tr><td align="left" valign="top">Ramalingam et al [<xref ref-type="bibr" rid="ref62">62</xref>], 2020</td><td align="left" valign="top">Singapore</td><td align="left" valign="top">Case report</td><td align="left" valign="top">n=1</td><td align="left" valign="top">64</td></tr><tr><td align="left" valign="top">Rose et al [<xref ref-type="bibr" rid="ref64">64</xref>], 2022</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Innovation report</td><td align="left" valign="top">n=19 enrolled</td><td align="left" valign="top">Median 57</td></tr><tr><td align="left" valign="top">Taylor et al [<xref ref-type="bibr" rid="ref46">46</xref>], 2022</td><td align="left" valign="top">United States</td><td align="left" valign="top">Multicenter pragmatic randomized clinical trial</td><td align="left" valign="top">I=349; C=342</td><td align="left" valign="top">Mean (SD) for I: 64.7 (14.9); C: 62.7 (15.5)</td></tr><tr><td align="left" valign="top">Kovaleva et al [<xref ref-type="bibr" rid="ref59">59</xref>], 2023</td><td align="left" valign="top">United States</td><td align="left" valign="top">Qualitative descriptive study</td><td align="left" valign="top">Patients (n=14), caregivers (n=12)</td><td align="left" valign="top">Not reported</td></tr><tr><td align="left" valign="top">Parker et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2020</td><td align="left" valign="top">United States</td><td align="left" valign="top">Prospective usability and acceptability study</td><td align="left" valign="top">Patient-caregiver dyads (n=10)</td><td align="left" valign="top">Median 50.5 [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]</td></tr><tr><td align="left" valign="top">Vlake et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2022</td><td align="left" valign="top">Netherlands</td><td align="left" valign="top">Multicenter randomized controlled trial</td><td align="left" valign="top">I=44; C=45</td><td align="left" valign="top">Median for I: 61 [<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref66">66</xref>]; C: 59 [<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref66">66</xref>]</td></tr><tr><td align="left" valign="top">Martin et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2021</td><td align="left" valign="top">Belgium</td><td align="left" valign="top">Prospective observational comparative study</td><td align="left" valign="top">I=14; C=13</td><td align="left" valign="top">Mean (SD) for I: 60.8 (10.4); C: 61.9 (10.7)</td></tr><tr><td align="left" valign="top">Zacharelou et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2025</td><td align="left" valign="top">International (Europe)</td><td align="left" valign="top">International qualitative focus group study</td><td align="left" valign="top">n=22</td><td align="left" valign="top">Range 35&#x2010;75</td></tr><tr><td align="left" valign="top">Kim et al [<xref ref-type="bibr" rid="ref56">56</xref>], 2021</td><td align="left" valign="top">Canada</td><td align="left" valign="top">Prospective observational study</td><td align="left" valign="top">n=12</td><td align="left" valign="top">Mean (SD): 66.0 (8.12)</td></tr><tr><td align="left" valign="top">Cha et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2026</td><td align="left" valign="top">South Korea</td><td align="left" valign="top">Prospective single-arm pilot study</td><td align="left" valign="top">n=25 enrolled; n=20 analyzed</td><td align="left" valign="top">Mean (SD): 52.7 (13.9)</td></tr><tr><td align="left" valign="top">Fortune et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2026</td><td align="left" valign="top">United States</td><td align="left" valign="top">Prospective observational substudy nested within a randomized clinical trial</td><td align="left" valign="top">n=52 enrolled; n=51 with valid activity-monitor data</td><td align="left" valign="top">Median for I: 67 [<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref71">71</xref>]; C: 64 [<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref71">71</xref>]</td></tr><tr><td align="left" valign="top">Rosa et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2026</td><td align="left" valign="top">Brazil</td><td align="left" valign="top">Stepped-wedge cluster randomized controlled trial</td><td align="left" valign="top">n=1916 randomized (I=1063; C=853); n=1687 in primary analysis</td><td align="left" valign="top">Mean 60.6 (SD 17.3)</td></tr><tr><td align="left" valign="top">Lathrop et al [<xref ref-type="bibr" rid="ref63">63</xref>], 2026</td><td align="left" valign="top">Chile</td><td align="left" valign="top">Case report</td><td align="left" valign="top">n=1</td><td align="left" valign="top">24</td></tr><tr><td align="left" valign="top">Boehm et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2026</td><td align="left" valign="top">United States</td><td align="left" valign="top">Pilot feasibility randomized controlled trial</td><td align="left" valign="top">n=91 randomized (I=46; C=45)</td><td align="left" valign="top">Median for I: 57 [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]; C: 56 [<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]</td></tr><tr><td align="left" valign="top">Ghiglieri et al [<xref ref-type="bibr" rid="ref61">61</xref>], 2026</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Theory-informed qualitative interview substudy</td><td align="left" valign="top">ICU survivors, n=35 (RR<sup><xref ref-type="table-fn" rid="table2fn5">e</xref></sup>=20; SC<sup><xref ref-type="table-fn" rid="table2fn6">f</xref></sup>=15); staff, n=6</td><td align="left" valign="top">Mean (SD) for RR: 56.2 (17.0); SC: 66.1 (9.3)</td></tr><tr><td align="left" valign="top">Apps et al [<xref ref-type="bibr" rid="ref65">65</xref>], 2026</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Multiple methods study</td><td align="left" valign="top">Questionnaire, n=59; interviews, n=30; n=75 unique participants</td><td align="left" valign="top">Median for questionnaire: 58 [<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref66">66</xref>]; interviews: 55.5 [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref61">61</xref>]</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>Age is reported as mean (SD), median (IQR), or range, as provided in the original studies. Linked reports from the same parent study were retained when they contributed distinct evidence; each parent study was counted once in the number of unique studies.</p></fn><fn id="table2fn2"><p><sup>b</sup>I: intervention group.</p></fn><fn id="table2fn3"><p><sup>c</sup>C: control or comparator group.</p></fn><fn id="table2fn4"><p><sup>d</sup>MDT: multidisciplinary team.</p></fn><fn id="table2fn5"><p><sup>e</sup>RR: remote rehabilitation.</p></fn><fn id="table2fn6"><p><sup>f</sup>SC: standard care.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Statistical and Analytical Approaches</title><p>Statistical and analytical approaches varied across study designs, ranging from descriptive and conventional group comparisons to adjusted regression, mixed-effects, and longitudinal or clustered models; qualitative studies used content, thematic, or framework-based analyses [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. Reported handling of home-generated digital data included synchronization checks, wear-time or data-completeness criteria, exclusion of insufficient observations, and aggregation across valid monitoring periods [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>], whereas explicit signal-level filtering or cross-device calibration was rarely reported. Detailed study-level information is provided in Table S2 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p></sec><sec id="s3-4"><title>Characteristics of Digital Health Technologies</title><sec id="s3-4-1"><title>Types of Digital Health Technologies</title><p>The included reports covered 7 categories of digital health technologies. Telerehabilitation was the most frequently represented category and included remotely delivered exercise, multicomponent rehabilitation, and rehabilitation support [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Telemedicine approaches primarily involved remote consultation, symptom review, care coordination, and virtual ICU recovery services [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. Other technologies included mobile health (mHealth) apps [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], wearable monitoring [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], VR [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], digital recovery platforms [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], and robot-assisted rehabilitation [<xref ref-type="bibr" rid="ref43">43</xref>].</p></sec><sec id="s3-4-2"><title>Duration and Setting</title><p>Intervention duration and timing varied substantially. The shortest approach was a single telemedicine consultation conducted within 14 days after hospital discharge [<xref ref-type="bibr" rid="ref39">39</xref>], whereas longer-term programs extended to 12 months and incorporated ongoing symptom monitoring, care coordination, or physical activity monitoring [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref53">53</xref>]. Structured rehabilitation programs commonly lasted 6 to 8 weeks [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref61">61</xref>] or approximately 12 weeks [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]. Other studies used shorter inpatient programs or assessed recovery at predefined postdischarge time points [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>].</p><p>Home-based delivery was the most common setting and was used for telemedicine, telerehabilitation, mHealth, wearable monitoring, and digital recovery platforms [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Other technologies were delivered in outpatient or post-ICU follow-up settings [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>], during inpatient recovery [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], or in specialized rehabilitation facilities [<xref ref-type="bibr" rid="ref43">43</xref>].</p></sec><sec id="s3-4-3"><title>Delivery Format</title><p>Delivery formats ranged from clinician-led synchronous interactions to asynchronous self-directed technologies. Synchronous videoconferencing or telephone-based delivery was frequently used for telemedicine and telerehabilitation [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Asynchronous or self-directed approaches included mobile apps, web-based recovery platforms, and wearable devices used for exercise guidance, recovery monitoring, goal tracking, or self-management support [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]. Several interventions adopted hybrid formats combining digital and in-person or multiple remote components [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Technology-assisted formats also included therapist- or researcher-assisted immersive VR [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref63">63</xref>] and supervised human-robot interaction [<xref ref-type="bibr" rid="ref43">43</xref>].</p></sec><sec id="s3-4-4"><title>Health Care Providers Involved</title><p>Digital health interventions involved a broad range of health care professionals. Physiotherapists were frequently involved in exercise-based rehabilitation, telecoaching, and technology-assisted rehabilitation [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. Physicians and ICU clinicians contributed to teleconsultation and virtual ICU recovery services [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>], while nurses were involved in care coordination, transitional care, and recovery support [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. Several interventions were delivered by multidisciplinary teams involving combinations of physicians, physiotherapists, occupational therapists, psychologists, pharmacists, rehabilitation professionals, and other recovery specialists [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Other approaches relied partly on self-directed use of mobile apps or wearable devices with limited direct professional supervision [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>].</p></sec><sec id="s3-4-5"><title>Functional Components of Digital Health Technologies</title><p>Exercise-based rehabilitation was the most frequently represented intervention component. These programs incorporated aerobic or endurance exercise, resistance or strengthening exercises, balance training, respiratory exercises, upper-limb training, functional activity, and individualized mobility exercises delivered through digital or technology-assisted formats [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. Monitoring and assessment represented another major function and included remote review of vital signs or symptoms, wearable-based monitoring of physical activity, and digital tracking of recovery progress [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]. Educational resources, goal setting, and self-management support were incorporated in several interventions [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], while teleconsultation, care coordination, psychological support, and peer support extended the role of digital technologies beyond exercise delivery alone [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>].</p><p>Explicit use of named theoretical models or frameworks was uncommon. Khan et al [<xref ref-type="bibr" rid="ref42">42</xref>] described the mobile critical care recovery program as a collaborative care model, while Apps et al [<xref ref-type="bibr" rid="ref65">65</xref>] reported a theoretically informed recovery goal menu structured according to the Canadian model of occupational performance and engagement and used the theoretical framework of acceptability (TFA) as an analytic lens. Ghiglieri et al [<xref ref-type="bibr" rid="ref61">61</xref>] also explicitly used the TFA to guide the qualitative study and analysis. Other studies incorporated theory-informed strategies or behavioral constructs, including biobehaviorally informed lifestyle coaching and motivational interviewing [<xref ref-type="bibr" rid="ref40">40</xref>], self-efficacy and motivation for physical activity [<xref ref-type="bibr" rid="ref45">45</xref>], and individualized goal setting with Goal Attainment Scaling [<xref ref-type="bibr" rid="ref64">64</xref>], but did not explicitly report a named overarching theoretical framework guiding intervention design. Overall, explicit theoretical grounding was inconsistently reported across the included evidence.</p><p><xref ref-type="table" rid="table3">Table 3</xref> summarizes the 7 digital health technology categories and their principal characteristics. <xref ref-type="fig" rid="figure2">Figure 2</xref> presents the distribution of these technologies across the ICF domains of body functions and structures, activities, and participation.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Summary of digital health technology categories and ICF-mapped mobility outcomes after critical illness.<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Digital health technology</td><td align="left" valign="bottom">Principal functions and delivery</td><td align="left" valign="bottom">ICF<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup> mobility domains and representative outcomes</td></tr></thead><tbody><tr><td align="left" valign="top">Telerehabilitation (n=9)</td><td align="left" valign="top">Remote exercise training, telecoaching, multicomponent rehabilitation, education, goal setting, and peer support; delivery: video, telephone, mobile apps, or hybrid formats</td><td align="left" valign="top">Body functions and structures: muscle strength and fatigue; activities: 6MWT<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup>, STST<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup>, SPPB<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup>, TUG<sup><xref ref-type="table-fn" rid="table3fn6">f</xref></sup>, disability, and physical-dependence measures; participation: return to work</td></tr><tr><td align="left" valign="top">Telemedicine<break/>(n=5)</td><td align="left" valign="top">Remote consultations, symptom review, medication management, care coordination, and virtual ICU recovery clinics; delivery: video, telephone, and electronic health support</td><td align="left" valign="top">Activities: 6MWT, ADL<sup><xref ref-type="table-fn" rid="table3fn7">g</xref></sup>, IADL<sup><xref ref-type="table-fn" rid="table3fn8">h</xref></sup>, and functional status</td></tr><tr><td align="left" valign="top">Mobile health<break/>(n=3)</td><td align="left" valign="top">App-guided exercise, rehabilitation education, goal tracking, symptom or mood monitoring, and wearable integration; delivery: mobile apps with self-directed or hybrid support</td><td align="left" valign="top">Body functions and structures: MRC-SS<sup><xref ref-type="table-fn" rid="table3fn9">i</xref></sup> and handgrip strength; activities: STST, TUG, ICU Mobility Scale, and FAC<sup><xref ref-type="table-fn" rid="table3fn10">j</xref></sup></td></tr><tr><td align="left" valign="top">Wearable monitoring<break/>(n=3)</td><td align="left" valign="top">Continuous or intermittent monitoring of physical activity and free-living performance; delivery: wrist-worn or consumer-grade wearable devices</td><td align="left" valign="top">Activities: daily step count, active time, cadence, 6MWT, and ADL</td></tr><tr><td align="left" valign="top">Virtual reality<break/>(VR; n=3)</td><td align="left" valign="top">Immersive rehabilitation, rehabilitation gaming, and ICU<sup><xref ref-type="table-fn" rid="table3fn11">k</xref></sup> recovery education; delivery: therapist-assisted or in-person immersive VR</td><td align="left" valign="top">Body functions and structures: handgrip strength; activities: MMI<sup><xref ref-type="table-fn" rid="table3fn12">l</xref></sup>, FIM<sup><xref ref-type="table-fn" rid="table3fn13">m</xref></sup>, and ambulation</td></tr><tr><td align="left" valign="top">Robot-assisted rehabilitation<break/>(n=1)</td><td align="left" valign="top">Robot-assisted therapeutic exercise; delivery: supervised human-robot interaction</td><td align="left" valign="top">Body functions and structures: handgrip strength; activities: 6MWT, balance performance, and FIM</td></tr><tr><td align="left" valign="top">Digital recovery platforms<break/>(n=3)</td><td align="left" valign="top">Goal setting, recovery monitoring, education, digital diaries, reminders, communication, and peer support; delivery: interactive web- or app-based platforms</td><td align="left" valign="top">Activities: ADL and functional independence; participation: activity participation and recovery goals explicitly related to meaningful life activities</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>Each report was assigned to one primary technology category according to its predominant digital function and mode of delivery; counts represent reports rather than unique parent studies. A report could contribute to multiple ICF domains when distinct mobility-related outcomes supported each assignment.</p></fn><fn id="table3fn2"><p><sup>b</sup>ICF: International Classification of Functioning, Disability and Health.</p></fn><fn id="table3fn3"><p><sup>c</sup>6MWT: 6-minute walk test.</p></fn><fn id="table3fn4"><p><sup>d</sup>STST: sit-to-stand test.</p></fn><fn id="table3fn5"><p><sup>e</sup>SPPB: short physical performance battery.</p></fn><fn id="table3fn6"><p><sup>f</sup>TUG: Timed Up and Go test.</p></fn><fn id="table3fn7"><p><sup>g</sup>ADL: activity of daily living.</p></fn><fn id="table3fn8"><p><sup>h</sup>IADL: instrumental activity of daily living.</p></fn><fn id="table3fn9"><p><sup>i</sup>MRC-SS: Medical Research Council Sum Score.</p></fn><fn id="table3fn10"><p><sup>j</sup>FAC: functional ambulation category.</p></fn><fn id="table3fn11"><p><sup>k</sup>ICU: intensive care unit.</p></fn><fn id="table3fn12"><p><sup>l</sup>MMI: Morton Mobility Index.</p></fn><fn id="table3fn13"><p><sup>m</sup>FIM: functional independence measure.</p></fn></table-wrap-foot></table-wrap><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Digital health technologies and ICF domains among ICU survivors. Each report was assigned to one primary technology category according to its predominant digital function and mode of delivery; for multicomponent interventions, the principal component delivering rehabilitation or recovery support determined the category. Each distinct mobility-related outcome was mapped to the ICF domain it most directly represented: body functions and structures, activities, or participation. A report could appear in more than one domain when it reported distinct outcomes representing those domains. Cell entries indicate outcome coverage, including qualitative findings, rather than intervention effectiveness; reports without a directly mappable mobility outcome are not shown in the matrix. Self-management, feasibility, and acceptability were not coded as mobility domains [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref62">62</xref>]. ICF: International Classification of Functioning, Disability and Health; ICU: intensive care unit.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v28i1e105445_fig02.png"/></fig></sec></sec><sec id="s3-5"><title>Mobility Assessment and Mobility-Related Findings</title><sec id="s3-5-1"><title>Mobility Assessment Tools</title><p>A wide range of mobility-related measures was reported across the included studies, reflecting substantial heterogeneity in the assessment of post-ICU recovery. The 6MWT was the most frequently reported assessment tool (n=7) [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], followed by sit-to-stand tests, including the 30-second and 1-minute sit-to-stand tests, which were used to assess functional exercise capacity (n=5) [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>].</p><p>Within the ICF domain of body functions and structures, muscle strength was assessed primarily using handgrip strength [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], with additional measures including the Medical Research Council Sum Score and Arm Curl Test. Activity-level outcomes were more diverse and included the 6MWT, sit-to-stand tests, Timed Up and Go test, Short Physical Performance Battery, de Morton Mobility Index, functional independence measure, Berg Balance Scale, ICU Mobility Scale, functional ambulation category, daily step count, ADLs, instrumental ADLs, disability, and physical dependence. Wearable-based measures of free-living activity, including daily step count, active time, and cadence, were reported by Hunter et al [<xref ref-type="bibr" rid="ref53">53</xref>], Kim et al [<xref ref-type="bibr" rid="ref56">56</xref>], and Fortune et al [<xref ref-type="bibr" rid="ref58">58</xref>].</p><p>Participation-level outcomes were infrequently assessed. Rosa et al [<xref ref-type="bibr" rid="ref48">48</xref>] assessed return to work; Zacharelou et al [<xref ref-type="bibr" rid="ref60">60</xref>] qualitatively explored participation in meaningful daily, community, or social activities; and Apps et al [<xref ref-type="bibr" rid="ref65">65</xref>] reported recovery goals explicitly related to meaningful life roles or participation. Overall, mobility assessment focused predominantly on body functions and activities, with limited coverage of participation.</p></sec><sec id="s3-5-2"><title>Mobility-Related Clinical Findings</title><p>Evidence from controlled and comparative studies was mixed (Table S3 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). Among studies with clinical primary outcomes, the 12-month mobile critical care recovery program did not significantly improve the SF-36 physical component summary compared with control [<xref ref-type="bibr" rid="ref42">42</xref>]. Remote multicomponent rehabilitation did not significantly improve the primary EQ-5D-5L utility outcome at 8 weeks [<xref ref-type="bibr" rid="ref44">44</xref>]. ICU-specific VR did not demonstrate consistent benefits in its primary psychological or health-related quality-of-life outcomes [<xref ref-type="bibr" rid="ref47">47</xref>]. In the stepped-wedge trial by Rosa et al [<xref ref-type="bibr" rid="ref48">48</xref>], overall EQ-5D-3L utility at 90 days was higher in the intervention group, but this difference was not significant when the analysis was restricted to survivors.</p><p>Findings for secondary mobility-related outcomes were also inconsistent. For the secondary 30-second sit-to-stand outcome, O&#x2019;Neill et al [<xref ref-type="bibr" rid="ref44">44</xref>] reported a significant adjusted between-group difference at 8 weeks favoring remote rehabilitation. In the robot-assisted rehabilitation trial, a significant group &#x00D7; time interaction was observed for the functional independence measure motor subscale, whereas consistent between-group advantages were not demonstrated across other functional measures [<xref ref-type="bibr" rid="ref43">43</xref>]. Rosa et al [<xref ref-type="bibr" rid="ref48">48</xref>] found no significant between-group differences in new disability, physical dependence, or return to work. Similarly, no clear between-group mobility benefit was demonstrated in the telemedicine study by Balakrishnan et al [<xref ref-type="bibr" rid="ref39">39</xref>] or in the telehealth vs in-person rehabilitation comparison by Mayer et al [<xref ref-type="bibr" rid="ref51">51</xref>]. In the observational study by Hunter et al [<xref ref-type="bibr" rid="ref53">53</xref>], step counts increased more at the multidisciplinary-team site than at control sites, although the nonrandomized design limits causal interpretation. Noncomparative studies reported improvements over time in mobility, exercise capacity, physical activity, or functional independence [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. These findings were used to describe recovery trajectories and outcome coverage rather than as evidence of intervention effectiveness.</p></sec></sec><sec id="s3-6"><title>Implementation Feasibility and User Acceptability</title><p>Evidence on feasibility, safety, adherence, usability, acceptability, and user experience was synthesized separately from clinical outcome evidence. Across the included reports, these outcomes were assessed using measures of recruitment and retention, intervention completion and adherence, safety, usability and satisfaction, and qualitative accounts of user experience and implementation barriers.</p></sec><sec id="s3-7"><title>Feasibility, Safety, and Adherence</title><p>Feasibility, safety, adherence, and implementation outcomes were synthesized separately from clinical effectiveness findings (Table S4 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). Several interventions reported favorable engagement or completion, although substantial variation was observed across studies. Remote multicomponent rehabilitation achieved full adherence in 73.2% (169/231) of participants, with 88.7% (205/231) attending at least one session [<xref ref-type="bibr" rid="ref44">44</xref>], while virtual post-ICU rehabilitation showed 73.6% (28/38) retention and 82% (23/28) adherence [<xref ref-type="bibr" rid="ref52">52</xref>]. Wearable-monitoring studies demonstrated the feasibility of collecting home activity data, but incomplete device use, technical failures, and missing data reduced data completeness [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. In the multicenter stepped-wedge trial, among 300 eligible intervention patients, 269 (89.7%) attended at least 1 ward session and 222 (74.0%) attended at least 1 postdischarge session [<xref ref-type="bibr" rid="ref48">48</xref>]. Thus, digital interventions were generally deliverable, but sustained participation and completeness of remotely generated data remained variable.</p></sec><sec id="s3-8"><title>Acceptability, Usability, and User Experience</title><p>Acceptability and user experience findings were generally favorable but were interpreted separately from clinical effectiveness (Table S5 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). Remote multicomponent rehabilitation received higher acceptability ratings than standard care [<xref ref-type="bibr" rid="ref44">44</xref>], while a mobile app prototype achieved median System Usability Scale scores of 76 among ICU survivors and 88 among caregivers [<xref ref-type="bibr" rid="ref54">54</xref>]. ICU-specific VR was associated with higher satisfaction with ICU aftercare [<xref ref-type="bibr" rid="ref47">47</xref>], and favorable satisfaction or acceptability was also reported for app-based rehabilitation, immersive VR, telemedicine recovery clinics, and digital recovery platforms [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]. Qualitative findings highlighted individualized support, continuity of care, reassurance, and professional access as facilitators, whereas technical burden, limited digital access, and insufficient personalization were recurrent barriers [<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>].</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This scoping review mapped the use of digital health technologies to support mobility recovery among ICU survivors across 7 technology categories. Interventions most commonly incorporated exercise-based rehabilitation, alongside monitoring, education, self-management support, and remote follow-up. Mobility outcomes were heterogeneous and concentrated on body functions and activity-level performance, with comparatively limited attention to participation. Although feasibility and acceptability were generally favorable when assessed, evidence of clinical effectiveness remained mixed, and long-term implementation data were limited.</p></sec><sec id="s4-2"><title>Remote and Telehealth-Based Technologies as a Major Strategy for Post-ICU Recovery</title><p>A notable finding of this review was that telemedicine and telerehabilitation were the most frequently adopted digital health technologies. This predominance may reflect the substantial and persistent rehabilitation needs of ICU survivors, who commonly experience long-term physical impairment, reduced exercise capacity, respiratory dysfunction, and difficulties accessing postdischarge rehabilitation services [<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]. Digital technologies offer an opportunity to extend rehabilitation beyond hospital settings and provide continuous support throughout the recovery trajectory [<xref ref-type="bibr" rid="ref69">69</xref>]. In addition to improving access to rehabilitation, remote and telehealth-based approaches may reduce geographical and transportation barriers, facilitate continuity of care after hospital discharge, enable timely monitoring of recovery, and strengthen patient self-management in home settings, where access to structured post-ICU rehabilitation is often limited.</p><p>The COVID-19 pandemic further accelerated the adoption of remote rehabilitation technologies. Eleven of the 24 (45.8%) included studies focused on survivors of COVID-19&#x2013;related critical illness, reflecting the urgent demand for scalable rehabilitation strategies during a period when infection-control measures substantially restricted conventional outpatient and community-based rehabilitation services. At the same time, the rapid expansion of telehealth infrastructure and increasing familiarity with digital health care delivery further facilitated the implementation of remote rehabilitation programs. Together, these factors contributed to the widespread use of telemedicine and telerehabilitation for supporting patients with persistent physical and respiratory impairments following severe COVID-19 [<xref ref-type="bibr" rid="ref70">70</xref>].</p><p>However, the predominance of COVID-19&#x2013;related studies should be considered when interpreting the current evidence. Compared with general ICU survivors, individuals recovering from COVID-19 may experience distinct recovery patterns, particularly persistent respiratory symptoms, postviral fatigue, and impaired exercise tolerance, which may influence both rehabilitation needs and responses to digital intervention [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. In contrast, evidence involving non-COVID ICU populations, such as survivors of sepsis, acute respiratory failure, prolonged mechanical ventilation, and other critical illnesses, remains relatively limited. Furthermore, many COVID-19&#x2013;related digital programs were rapidly developed during the pandemic and were commonly evaluated over short intervention periods, with limited evidence regarding their long-term sustainability and integration into routine post-ICU care [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. Beyond these population-specific considerations, successful implementation of remote rehabilitation also depends on patients&#x2019; digital literacy, access to internet-enabled devices, reliable connectivity, and, in some cases, caregiver support. These factors may influence patient engagement, equity of access, and the scalability of digital rehabilitation programs in routine clinical practice.</p></sec><sec id="s4-3"><title>Exercise-Based Rehabilitation Remains the Core Functional Component of Digital Health Technologies</title><p>Exercise-based rehabilitation emerged as the most frequently reported functional component among the included digital health technologies. This finding is unsurprising given that persistent physical impairments, including muscle weakness, reduced exercise tolerance, and limitations in physical functioning, are among the most common consequences experienced by ICU survivors after critical illness. Previous studies have shown that these impairments may persist for months or even years after hospital discharge and contribute to long-term disability, reduced health-related quality of life, and difficulties returning to previous life roles [<xref ref-type="bibr" rid="ref22">22</xref>-<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. Consequently, exercise rehabilitation remains a cornerstone of post-ICU recovery programs and is strongly recommended to mitigate long-term physical disability and promote functional restoration [<xref ref-type="bibr" rid="ref75">75</xref>]. This predominance may also reflect the characteristics of current digital health technologies, as exercise programs are more readily delivered through telehealth platforms, and their outcomes can be objectively monitored using wearable devices and standardized performance measures. By contrast, broader domains such as social participation and community reintegration are less amenable to remote measurement and digital monitoring.</p><p>However, the predominance of exercise-centered technologies highlights an important gap in current digital rehabilitation strategies. Mobility recovery after critical illness is increasingly recognized as a multidimensional process encompassing body functions and structures, activities, and participation [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref76">76</xref>-<xref ref-type="bibr" rid="ref78">78</xref>]. Consistent with the findings of this review, existing digital health technologies primarily addressed body functions and activity-level performance, particularly exercise capacity, muscle strength, and functional performance, while participation outcomes were less frequently assessed. Therefore, future digital health technologies should move beyond physical rehabilitation alone and incorporate more comprehensive, person-centered recovery goals.</p><p>Furthermore, although digital technologies offer opportunities for continuous monitoring and personalized rehabilitation, current apps largely remain tools for remote delivery and assessment rather than adaptive rehabilitation systems. Future integration of wearable sensing, AI, and real-time feedback may facilitate closed-loop rehabilitation models that dynamically tailor interventions according to patients&#x2019; changing recovery needs [<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref80">80</xref>].</p></sec><sec id="s4-4"><title>Emerging Digital Technologies: From Feasibility to Patient-Centered Implementation</title><p>Beyond conventional telemedicine and telerehabilitation, emerging digital technologies included VR, rehabilitation robots, wearable activity monitoring, and digital recovery platforms. Current evidence for these technologies was predominantly derived from feasibility, pilot, and observational studies, with generally favorable feasibility and user experience findings when assessed. However, evidence of clinical effectiveness remained limited and inconsistent. VR-based rehabilitation was perceived as enjoyable and feasible among ICU survivors, with no serious adverse events reported [<xref ref-type="bibr" rid="ref50">50</xref>]. App-based and video-supported rehabilitation programs also reported favorable adherence and retention, supporting their implementation feasibility rather than establishing clinical effectiveness [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. In addition, digital recovery platforms and virtual follow-up services were valued for facilitating access to information, self-management, and communication with health care professionals [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>].</p><p>However, the current evidence primarily reflects early-stage implementation, as many emerging digital technologies were evaluated in feasibility studies, pilot trials, or small observational studies with relatively short follow-up periods. Although several studies reported favorable usability and acceptability through satisfaction questionnaires, usability scales, or qualitative interviews, a comprehensive understanding of long-term user engagement and implementation barriers remains limited. Future development of digital rehabilitation technologies should therefore adopt more patient-centered approaches, including co-design involving ICU survivors and caregivers, as well as mixed methods evaluations that integrate quantitative usability measures with qualitative exploration of user experiences. In addition, successful implementation will require attention to data privacy and security, integration into routine clinical care, and adequate training and support for health care professionals. Such considerations may help ensure that emerging digital technologies are not only technically feasible but also meaningful, accessible, and sustainable in supporting long-term recovery after critical illness.</p></sec><sec id="s4-5"><title>Heterogeneity and Narrowness of Mobility Outcome Measurement</title><p>Another important finding of this review was the substantial heterogeneity in mobility assessment and outcome measurement. Most studies focused on basic physical capacity and functional performance, commonly assessed using the 6MWT, sit-to-stand tests, handgrip strength, the Timed Up and Go test, and other performance-based measures [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Although these outcomes are clinically meaningful for evaluating physical recovery after critical illness, they capture only part of the multidimensional nature of mobility.</p><p>Measures addressing broader activity and participation outcomes were less frequently reported, including functional independence [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], ADLs, activity participation, and mobility- or participation-related recovery goals [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]. This imbalance suggests that current digital health research has predominantly evaluated mobility through body functions and activity-level performance rather than across the full spectrum of post-ICU functioning.</p><p>The heterogeneity of outcome measurement remains a major challenge for comparing and synthesizing evidence across digital rehabilitation studies. The PRACTICE (Physical Rehabilitation Core Outcomes in Critical Illness) core outcome set provides a framework to promote standardized reporting of physical rehabilitation outcomes in critically ill populations [<xref ref-type="bibr" rid="ref81">81</xref>]. However, as digital health interventions increasingly extend beyond exercise training to include remote monitoring, self-management, and long-term recovery support, future research should combine standardized core outcomes with broader multidimensional assessments that reflect independence, participation, and patient-centered recovery trajectories. Analytical approaches were also heterogeneous, ranging from descriptive and unadjusted comparisons to adjusted regression, mixed-effects, and longitudinal or clustered models. This variation reflected differences in study design but also limited the comparability of effect estimates across studies. Future studies should prespecify analytical strategies appropriate to repeated and longitudinal measurements and consistently report effect estimates with measures of uncertainty.</p><p>The handling of home-generated digital data was also inconsistently reported. Reported approaches included synchronization checks, wear-time or data-completeness thresholds, exclusion of insufficient observations, aggregation across valid monitoring periods, and missing-data assessment, whereas explicit signal-level artifact filtering and cross-device calibration were rarely described. Future studies should prespecify device validation, valid-wear and nonwear criteria, data-cleaning procedures, and missing-data handling to improve the reproducibility and interpretability of remotely generated data.</p></sec><sec id="s4-6"><title>Implications for Future Research</title><p>Several implications for future research emerged from this review. First, more adequately powered randomized controlled trials with longer follow-up periods are needed to establish the long-term effectiveness and sustainability of digital health technologies, given that mobility recovery after critical illness is a prolonged and dynamic process. Second, future studies should move beyond short-term physical outcomes and incorporate multidimensional recovery indicators, including independence in ADLs, community and social participation, return to occupational or caregiving roles, patient-reported physical function, and individualized mobility- or participation-related recovery goals. Third, theoretical foundations were infrequently and inconsistently reported; future interventions would benefit from clearly articulated behavioral or rehabilitation frameworks where appropriate. Finally, future research should consider implementation factors, including digital literacy, technology accessibility, caregiver involvement, and health equity, to support broader adoption in ICU survivorship care.</p></sec><sec id="s4-7"><title>Strengths and Limitations</title><p>This review has several strengths. A comprehensive search strategy was applied, and evidence was synthesized across technology types, delivery models, intervention components, and mobility-related outcomes. The review also identified important gaps in outcome measurement, theoretical grounding, and implementation evidence.</p><p>Several limitations should be acknowledged. First, although 27 reports representing 24 unique parent studies were included, many were feasibility, pilot, qualitative, or small observational studies, limiting conclusions regarding clinical effectiveness. Second, substantial heterogeneity in populations, interventions, outcome measures, and analytical approaches limited direct comparisons across studies. Third, a substantial proportion of the evidence was derived from survivors of COVID-19&#x2013;related critical illness, which may limit generalizability to the broader ICU survivor population. In addition, classifying multicomponent interventions according to their predominant digital function may have simplified the overlap between technology categories. Finally, no formal methodological quality or risk-of-bias appraisal was conducted; therefore, differences in study quality were not incorporated into the synthesis, and findings regarding clinical effectiveness should be interpreted cautiously.</p></sec><sec id="s4-8"><title>Conclusions</title><p>Digital health technologies have been applied across diverse approaches to support mobility recovery among ICU survivors, with telemedicine and telerehabilitation being the most frequently used. Current evidence predominantly addresses body functions and activity-level performance, with limited attention to participation. Although feasibility and acceptability were generally favorable, evidence of clinical effectiveness remains inconsistent, highlighting the need for rigorous longitudinal studies using multidimensional, patient-centered mobility outcomes.</p></sec></sec></body><back><notes><sec><title>Generative AI Use</title><p>During the preparation of this manuscript, the authors used OpenAI&#x2019;s GPT-6 (accessed September 24, 2026) solely to generate vector graphics for elements in <xref ref-type="fig" rid="figure2">Figure 2</xref>. The AI tool was not involved in the layout or arrangement of <xref ref-type="fig" rid="figure2">Figure 2</xref>, the creation or formatting of any tables, or any other aspect of the manuscript. All image layout, figure composition, table preparation, study design, data collection, data analysis, data interpretation, and manuscript writing were performed entirely by the authors. The AI-generated vector elements were reviewed, selected, and, where necessary, edited by the authors, who take full responsibility for the final content and integrity of <xref ref-type="fig" rid="figure2">Figure 2</xref> and the entire manuscript. No other generative AI tools were used in any portion of the manuscript generation.</p></sec><sec><title>Funding</title><p>This study was supported by the Xinhua Hospital &#x201C;Discipline Peak-Climbing Plan&#x201D; Construction Project (XKPF2024305), the Shanghai Jiao Tong University School of Medicine Nursing Development Program (SJTUHLXK2022), and the General Project of the Commission of Science, Technology and Economy of Yangpu District (YPM202536). The funders had no role in the study design, study selection, data charting, analysis, interpretation of the findings, manuscript preparation, or decision to submit the manuscript.</p></sec><sec><title>Data Availability</title><p>The study-level data extracted from the included publications, the data-charting framework, and the complete database-specific search strategies are provided in the multimedia appendices. No individual participant-level data were collected or generated for this study. Additional materials are available from the corresponding author upon reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: YY, JZ, XG</p><p>Data curation: YY, JZ</p><p>Formal analysis: YY, JZ</p><p>Investigation: SP</p><p>Methodology: YY, JZ</p><p>Project administration: XG</p><p>Supervision: XG</p><p>Validation: SP</p><p>Writing &#x2013; original draft: YY, JZ</p><p>Writing &#x2013; review &#x0026; editing: JQ, LC, XG</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">6MWT</term><def><p>6-minute walk test</p></def></def-item><def-item><term id="abb2">ADL</term><def><p>activity of daily living</p></def></def-item><def-item><term id="abb3">ICF</term><def><p>International Classification of Functioning, Disability, and Health</p></def></def-item><def-item><term id="abb4">ICU</term><def><p>intensive care unit</p></def></def-item><def-item><term id="abb5">mHealth</term><def><p>mobile health</p></def></def-item><def-item><term id="abb6">PCC</term><def><p>population, concept, and context</p></def></def-item><def-item><term id="abb7">PRACTICE</term><def><p>Physical Rehabilitation Core Outcomes in Critical Illness</p></def></def-item><def-item><term id="abb8">PRISMA-ScR</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews</p></def></def-item><def-item><term id="abb9">SF-36</term><def><p>36-item Short Form Health Survey</p></def></def-item><def-item><term id="abb10">TFA</term><def><p>theoretical framework of acceptability</p></def></def-item><def-item><term id="abb11">VR</term><def><p>virtual reality</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Needham</surname><given-names>DM</given-names> 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