<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v28i1e102008</article-id><article-id pub-id-type="doi">10.2196/102008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Exploring Social Media Use and Anxiety Symptoms in Health Care Workers During the COVID-19 Pandemic: Cross-Sectional Secondary Data Analysis</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Powell</surname><given-names>Melissa</given-names></name><degrees>MS, MSN, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Choi</surname><given-names>Kristen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Buhr</surname><given-names>Russell G</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Wisk</surname><given-names>Lauren E</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><institution>Division of General Internal Medicine and Human Services Research, The National Clinician Scholars Program, University of California</institution><addr-line>1100 Glendon Ave Suite 900</addr-line><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff2"><institution>Fielding School of Public Health, Department of Health Policy and Management, Joe C. Wen School of Nursing, University of California</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff3"><institution>Fielding School of Public Health, Health Policy and Management, Department of Medicine, University of California</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff4"><institution>Department of General Internal Medicine &#x0026; Health Services Research, University of California</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Brini</surname><given-names>Stefano</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Albzour</surname><given-names>Nisreen Nayef Awad</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Dou</surname><given-names>Pengyue</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Mahmoud</surname><given-names>Randa Salah Gomaa</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Hu</surname><given-names>Yihan</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Melissa Powell, MS, MSN, PhD, Division of General Internal Medicine and Human Services Research, The National Clinician Scholars Program, University of California, 1100 Glendon Ave Suite 900, Los Angeles, CA, 90024, United States, 310-853-0918; <email>melissapowellrn@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2026</year></pub-date><volume>28</volume><elocation-id>e102008</elocation-id><history><date date-type="received"><day>21</day><month>05</month><year>2026</year></date><date date-type="rev-recd"><day>28</day><month>07</month><year>2026</year></date><date date-type="accepted"><day>04</day><month>08</month><year>2026</year></date></history><copyright-statement>&#x00A9; Melissa Powell, Kristen Choi, Russell G Buhr, Lauren E Wisk. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 15.10.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2026/1/e102008"/><abstract><sec><title>Background</title><p>Health care workers (HCWs) experienced significant mental health challenges, particularly anxiety, during the COVID-19 pandemic. Although social media became a primary source of information and connection, it was also a potential source of stress. The influence of social media on HCWs&#x2019; anxiety is not well understood.</p></sec><sec><title>Objective</title><p>This study examined associations between social media use and anxiety symptoms among HCWs during the COVID-19 pandemic.</p></sec><sec sec-type="methods"><title>Methods</title><p>We conducted a secondary, cross-sectional analysis of data from the 2021 UC-COVID study (N=427 HCWs). Anxiety symptoms were assessed using the Generalized Anxiety Disorder-2 (GAD-2). Social media use across multiple platforms (Twitter, Facebook, Instagram, other social media platforms, and other media sources) was evaluated using factor analysis to create a single variable for social media use. Logistic regression models estimated associations between overall social media use and anxiety symptoms, both unadjusted and adjusted for demographic, occupational, and health-related characteristics.</p></sec><sec sec-type="results"><title>Results</title><p>Factor analysis supported a single latent factor representing overall social media use, with all platform indicators loading significantly on the factor (<italic>P</italic>&#x003C;.001) and with moderate loadings (0.33&#x2010;0.59). Of 427 HCWs, the mean age was 44.3 (SD 13.5), and the majority identified as female (n=314, 73.5%) and as working in a hospital location (n=136, 43.6%). Facebook was used the most, with 54% (n=230) of participants using the platform at least once per day. A total of 29% reported clinically relevant anxiety symptoms (GAD-2 &#x2265;3). Using the social media variable from the factor analysis, higher social media use was significantly associated with anxiety symptoms (odds ratio [OR] 1.77, CI 1.15&#x2010;2.73). Older age was significantly associated with reduced anxiety symptoms (adjusted odds ratio [aOR] 0.97, CI 0.95&#x2010;0.99). HCWs with a history of mental health diagnoses reported higher levels of anxiety symptoms (aOR 2.33, CI 1.35&#x2010;4.03). Non-Hispanic Asian HCWs reported fewer anxiety symptoms compared to Non-Hispanic White HCWs (aOR 0.39, CI 0.19&#x2010;0.80). Participants reporting higher income had significantly lower odds of anxiety symptoms than those in the lower-income group (aOR 0.51, CI 0.30&#x2010;0.87).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Study findings highlight the multifactorial nature of anxiety symptoms in HCWs and the need to consider social media use as an important contributor. Integrating HCWs and multiplatform social media use into a single measure offered an innovative lens on digital behavior and anxiety symptoms. The rapidly evolving digital landscape underscores the need for continued research. Future studies should include emerging social media platforms (ie, TikTok, Reddit, YouTube) as usage patterns shift over time. Longitudinal and mixed methods approaches are necessary to understand patterns and methods of social media use over time. Larger and more diverse HCW samples, stronger mental health measures (eg, GAD-7, depression, and burnout scales), and analyses stratified by clinical role and sociodemographic factors will be essential to guide interventions supporting mental health and well-being.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov NCT04373135; https://clinicaltrials.gov/study/NCT04373135</p></sec></abstract><kwd-group><kwd>health care workers</kwd><kwd>anxiety</kwd><kwd>social media</kwd><kwd>digital behavior</kwd><kwd>COVID-19</kwd><kwd>mental health</kwd><kwd>factor analysis</kwd><kwd>occupational health</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><sec id="s1-1"><title>Background</title><p>Health care workers (HCWs) work stressful jobs and have been exposed to higher levels of burnout in the aftermath of the COVID-19 pandemic [<xref ref-type="bibr" rid="ref1">1</xref>]. Nearly half of HCWs reported experiencing burnout as of 2022, compared to one-third in 2018, and turnover intention among HCWs increased by 11% from 2018 to 2022 [<xref ref-type="bibr" rid="ref1">1</xref>]. The COVID-19 pandemic led to increased isolation and negatively affected mental and physical health [<xref ref-type="bibr" rid="ref2">2</xref>], both of which are important for protecting against burnout and maintaining general well-being [<xref ref-type="bibr" rid="ref2">2</xref>]. One understudied factor regarding HCWs&#x2019; well-being in the COVID-19 pandemic has been the impact of social media use. Examining the relationships between social media use and anxiety symptoms among HCWs may shed new light on potential contributing factors affecting mental health in the current technological landscape.</p></sec><sec id="s1-2"><title>Review of Relevant Scholarship</title><p>Internet addiction, which includes 24/7 access to and frequent use of media, including social media use, has been shown to contribute to mental health conditions [<xref ref-type="bibr" rid="ref3">3</xref>]. During the COVID-19 pandemic, the media became less positive and included discussions of loneliness, anxiety, and depression across media sources [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. Incidents of violence and aggression toward HCWs increased during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>], with patients being influenced by content found online [<xref ref-type="bibr" rid="ref6">6</xref>]. Additionally, information overload stemming from the media more broadly has been connected to COVID-19 fatalism and COVID-19 exhaustion [<xref ref-type="bibr" rid="ref7">7</xref>]. In contrast, data exist that highlight potential benefits of social media use for HCWs by providing outlets for education, connection, and health promotion, but finding the right balance of exposure is crucial [<xref ref-type="bibr" rid="ref8">8</xref>] and not yet defined. Managing the volume of social media content available, or the time spent consuming content, is particularly hard to measure [<xref ref-type="bibr" rid="ref8">8</xref>].</p><p>Knowledge of social media&#x2019;s impact on HCWs is generally limited, specifically in the context of the COVID-19 pandemic, although one study found high levels of anxiety and fear (over 50% of their sample), with social media use being the most influential variable on anxiety [<xref ref-type="bibr" rid="ref9">9</xref>]. The extent of social media use and the specific types of use are not frequently surveyed; media are often studied broadly, including news and print media and are less frequently studied in HCW samples. Mainstream media, including social media and news outlets, have been analyzed to look at factors like diversity and representation among HCWs that are featured across media sources [<xref ref-type="bibr" rid="ref10">10</xref>], but this work has not focused on the role of HCW media consumption in mental health outcomes. Although some HCW groups, such as emergency medicine physicians [<xref ref-type="bibr" rid="ref4">4</xref>], have been studied to understand the impact of media, many HCW groups have not been researched nor compared to one another to understand any differences in the experience of anxiety. A literature review of nurses and social media use related to the COVID-19 pandemic found that mostly cross-sectional surveys were conducted; social media use was not often the main variable of interest, the populations varied widely, and mental health outcomes were not measured [<xref ref-type="bibr" rid="ref11">11</xref>].</p><p>Sociodemographic factors have been identified as important correlates of anxiety in studies examining mental health during the COVID-19 pandemic, including among HCWs. One study suggested that females reported greater fear of COVID-19 infection [<xref ref-type="bibr" rid="ref9">9</xref>]. Another study found that adults younger than 35 years were more likely to experience anxiety and depression compared with older adults [<xref ref-type="bibr" rid="ref12">12</xref>]. Additionally, a systematic review found that frequent media consumption related to the COVID-19 pandemic was associated with increased anxiety, while gender, age, and the presence of chronic illness were also associated with poorer mental health outcomes [<xref ref-type="bibr" rid="ref13">13</xref>]. Together, these findings suggest that sociodemographic characteristics may contribute to differences in mental health outcomes and should be considered when developing interventions to support HCWs.</p><p>More recent evidence since the onset of the COVID-19 pandemic suggests that HCWs continue to experience elevated levels of anxiety, psychological distress, and emotional exhaustion beyond the acute phase of the COVID-19 pandemic [<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref16">16</xref>]. At the same time, HCWs increasingly engage with social media and digital platforms for information, professional communication, and social connection, yet the influence of social media use on mental health outcomes remains poorly understood [<xref ref-type="bibr" rid="ref17">17</xref>]. Existing research has often focused on specific professional groups or treated broad media use as a secondary variable, leaving limited understanding of how social media use is associated with anxiety across diverse groups of HCW disciplines [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>].</p></sec><sec id="s1-3"><title>Study Aims</title><p>The study aims of this secondary analysis were broadly framed around exploring the following research question: what associations exist between social media use and anxiety levels among HCWs during the COVID-19 pandemic while controlling for sociodemographic factors?</p></sec></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Design</title><p>We conducted a secondary, cross-sectional analysis of data from the first time point of the University of California, Los Angeles&#x2019; (UCLA&#x2019;s) UC-COVID (understanding community considerations, opinions, values, impacts, and decisions for COVID-19) Study [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. The UC-COVID Study [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] is a community engagement study that included an internet-based survey conducted at three time points from 2020 to 2022; data for this analysis are from the baseline survey, which was conducted during the acute period of the COVID-19 pandemic in 2020.</p></sec><sec id="s2-2"><title>Inclusion and Exclusion Criteria</title><p>Participants for the baseline survey were adults aged 18 years or older. For our secondary analysis, participants were included if they identified as an HCW (n=582). Participants were excluded from the analysis if complete data were not available for the primary exposure and outcome variables (n=32 were excluded). Participants with missing data for only the primary exposure (n=94 for missing data and n=21 for &#x201C;prefer not to answer&#x201D; for social media use) or only the outcome variables (n=3 for missing data and n=5 for &#x201C;prefer not to answer&#x201D; for anxiety symptoms) were also excluded, resulting in a final analytic sample of 427. Noted, the majority of missing data resulted from survey attrition prior to reaching the section of the survey that included data on social media use, which was toward the end of the survey.</p></sec><sec id="s2-3"><title>Participant Characteristics</title><p>Survey participants self-reported demographic data (eg, age, gender, race, ethnicity, income, religion, and politics), work roles, health status and chronic conditions, social and behavioral habits, media use, and values and beliefs related to the COVID-19 pandemic.</p></sec><sec id="s2-4"><title>Sampling Procedure</title><p>For the UC-COVID Study, participants were originally recruited from May to September 2020 through social media platforms (eg, Facebook, Twitter) and direct recruitment through organizations (eg, University of California, University of California Health Systems, and AltaMed) and professional societies (eg, Society for General Internal Medicine).</p></sec><sec id="s2-5"><title>Sample Size, Power, and Precision</title><p>The sample size for this study (N=427) was determined by the availability of participants in the existing dataset for this secondary analysis; no a <italic>priori</italic> power analysis was conducted to determine sample size. To contextualize the adequacy of the sample, a post hoc power analysis was conducted using G*Power 3.1 (Heinrich Heine University D&#x00FC;sseldorf) to determine the smallest effect size detectable given the achieved sample size, assuming a logistic regression framework. With <italic>&#x03B1;</italic>=.05, 80% power, an outcome prevalence of 29%, and an <italic>R</italic>&#x00B2; of 0.12 between the social media use predictor and other model covariates, the study had adequate power to detect an odds ratio (OR) of 1.38 (or its inverse, 0.72) for the association between social media use and anxiety. Effects smaller than this threshold would not have been reliably detected at conventional power levels given the available sample.</p></sec><sec id="s2-6"><title>Measures and Covariates</title><p>To assess our primary outcome, anxiety symptoms, we used the 2-item version of the Generalized Anxiety Disorder screening tool (GAD-2). This tool assesses the frequency of anxiety symptoms in the past 2 weeks: (1) feeling nervous, anxious, or on edge, and (2) being unable to stop or control worrying. These items are rated on a 0-3 scale from not at all to nearly every day. Items are summed; a score of 3 or greater is clinically suggestive of anxiety [<xref ref-type="bibr" rid="ref20">20</xref>].</p><p>To measure social media use (the primary exposure), participants reported how often they used various online platforms to obtain news or information. Five items assessed the frequency of engagement with the following: (1) Twitter, (2) Instagram, (3) Facebook, and (4) other social media platforms (for which participants could specify the platform), and (5) other online video websites (eg, YouTube and TikTok). Each item used the same response scale, ranging from: Several times a day, About once a day, A few times a week, Every few weeks, Less often than every few weeks, to I never use this platform. Responses were coded such that higher values indicated greater use of the platform.</p><p>We assessed several sociodemographic characteristics to examine additional correlates of anxiety symptoms. HCW type was categorized into 4 groups: physicians and advanced practice providers, registered nurses and medical assistants, clinical support services (ie, respiratory therapists, physical therapists, or social workers), and other HCWs which included administrative HCWs and workers in adjacent health care settings (ie, veterinarians or dentists). Workplace setting (HCW location) was classified as hospital-based, outpatient, or other/not currently working (ie, other settings such as schools or public health). Age was treated as a continuous variable. Sex was coded as a binary measure: male and female. Race and ethnicity were captured using a combined four-level variable due to small group sizes: (1) non-Hispanic/White, (2) non-Hispanic/non-White (including Black/African American, American Indian/Alaska Native, and multiracial), (3) non-Hispanic/Asian (including Asian and Native Hawaiian/Pacific Islander), and (4) Hispanic/Latino. Educational attainment was dichotomized into less than a bachelor&#x2019;s degree vs a bachelor&#x2019;s degree or higher. Annual household income was categorized into 2 income brackets: less than US $100,000 annually, or US $100,000 or greater annually, which was approximately the median household income level in the state of California [<xref ref-type="bibr" rid="ref21">21</xref>]. Political affiliation was operationalized as 4 categories: conservative, moderate, liberal, and nonpolitical. Religious affiliation was captured through an indicator reflecting endorsement of any religious identification vs none (including agnostic and atheist). Finally, participants reported whether they had a history of a mental health diagnosis, coded as a binary variable.</p></sec><sec id="s2-7"><title>Missing Data</title><p>Participants with missing data for the primary exposure and outcome variables were excluded (n=32); participants with missing data for only the primary exposure (n=94 for missing data and n=21 for &#x201C;prefer not to answer&#x201D; for social media use) or only the outcome variables (n=3 for missing data and n=5 for &#x201C;prefer not to answer&#x201D; for anxiety symptoms) were also excluded. For all other covariates with missing data (ie, work location, political affiliation, religious affiliation, and income), a missing data category was used to retain the analytic sample size of 427. The use of missing categories increases the potential for residual confounding due to misclassification of covariates with missing data&#x2013;a limitation of this study. Additionally, to characterize the missing-data mechanism for the primary exposure and outcome, we conducted Little&#x2019;s missing completely at random test [<xref ref-type="bibr" rid="ref22">22</xref>], separately for the exposure and core covariates and for the outcome, and examined whether missingness tracked the survey platform&#x2019;s section-completion indicators (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p></sec><sec id="s2-8"><title>Analytic Strategy</title><p>Statistical analyses were conducted in Stata (StataCorp, LLC; version 18.0). Our significance level was set at a two-sided &#x03B1; of .05. A confirmatory factor analysis (CFA) was conducted to evaluate whether 5 indicators of social media use&#x2014;Twitter, Instagram, Facebook, other social media, and other internet use&#x2014;reflected a unified latent construct of social media use. All indicators were specified as reflective measures loading onto a single latent factor (based on the results of an exploratory factor analysis) for which higher values indicated greater social media use, and standardized coefficients were estimated to assess model fit.</p><p>Descriptive statistics and appropriate bivariate tests (continuous variables were assessed using 2-tailed <italic>t</italic> tests, and categorical variables were compared using chi-square tests or Fisher exact tests, as appropriate given group sizes) were used to describe the prevalence of symptoms of anxiety by various characteristics The frequency of social media use by platform was descriptively reported in <xref ref-type="table" rid="table1">Table 1</xref>. We estimated a series of logistic regression models to estimate the association between social media use and anxiety, both unadjusted and adjusted for covariates (<xref ref-type="table" rid="table2">Table 2</xref>). The social media use score derived from the CFA was treated as a continuous variable; ORs represented the change in odds of anxiety symptoms per one-unit (approximately one SD) increase in overall social media use. To construct a parsimonious adjusted model, covariates found to be significantly associated with anxiety symptoms in bivariate analyses were included.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Frequency of social media (SM) use by platform (N=427)<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup>.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Platform</td><td align="left" valign="bottom">Several times a day, n (%)</td><td align="left" valign="bottom">Once a day, n (%)</td><td align="left" valign="bottom">A few times a week, n (%)</td><td align="left" valign="bottom">Every few weeks, n (%)</td><td align="left" valign="bottom">Less often than every few weeks, n (%)</td><td align="left" valign="bottom">Never, n (%)</td></tr></thead><tbody><tr><td align="left" valign="top">Twitter (X)</td><td align="left" valign="top">50 (11.7)</td><td align="left" valign="top">36 (8.4)</td><td align="left" valign="top">32 (7.5)</td><td align="left" valign="top">33 (7.7)</td><td align="left" valign="top">42 (9.8)</td><td align="left" valign="top">234 (54.8)</td></tr><tr><td align="left" valign="top">Instagram</td><td align="left" valign="top">92 (21.6)</td><td align="left" valign="top">57 (13.4)</td><td align="left" valign="top">47 (11.0)</td><td align="left" valign="top">28 (6.6)</td><td align="left" valign="top">51 (11.9)</td><td align="left" valign="top">152 (35.6)</td></tr><tr><td align="left" valign="top">Facebook</td><td align="left" valign="top">139 (32.6)</td><td align="left" valign="top">91 (21.3)</td><td align="left" valign="top">55 (12.9)</td><td align="left" valign="top">26 (6.1)</td><td align="left" valign="top">35 (8.2)</td><td align="left" valign="top">81 (19.0)</td></tr><tr><td align="left" valign="top">Other SM</td><td align="left" valign="top">26 (6.1)</td><td align="left" valign="top">38 (8.9)</td><td align="left" valign="top">49 (11.5)</td><td align="left" valign="top">26 (6.1)</td><td align="left" valign="top">30 (7.0)</td><td align="left" valign="top">258 (60.4)</td></tr><tr><td align="left" valign="top">Other internet</td><td align="left" valign="top">33 (7.7)</td><td align="left" valign="top">42 (9.8)</td><td align="left" valign="top">78 (18.3)</td><td align="left" valign="top">45 (10.5)</td><td align="left" valign="top">58 (13.6)</td><td align="left" valign="top">171 (40.1)</td></tr><tr><td align="left" valign="top">SM use score (mean SD; min-max)</td><td align="char" char="." valign="top">&#x2014;<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="char" char="." valign="top">0.0 (0.48; &#x2013;0.78 to 1.28)</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>The frequency of social media use across the platforms, with usage frequencies of several times a day, once a day, a few times a week, every few weeks, less often than every few weeks, or never. The SM use score is the single latent variable derived from the factor analysis.</p></fn><fn id="table1fn2"><p><sup>b</sup>Not applicable.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Associations between social media use and anxiety symptoms.<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variable</td><td align="left" valign="bottom" colspan="2">Model 1</td><td align="left" valign="bottom" colspan="3">Model 2</td></tr></thead><tbody><tr><td align="left" valign="top"/><td align="left" valign="top">OR<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup> (95% CI)</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top" colspan="2">OR (95% CI)</td><td align="left" valign="top"><italic>P</italic> value</td></tr><tr><td align="left" valign="top">Social media use</td><td align="char" char="." valign="top">1.77 (1.15-2.73)</td><td align="char" char="." valign="top">.009</td><td align="left" valign="top" colspan="2">1.74 (1.08&#x2010;2.83)</td><td align="left" valign="top">.02</td></tr><tr><td align="left" valign="top">Age</td><td align="char" char="." valign="top">&#x2014;<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.97 (0.95&#x2010;0.99)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top" colspan="6">Race/ethnicity (reference: White)</td></tr><tr><td align="left" valign="top">&#x2003;Non-Hispanic non-White</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.77 (0.29&#x2010;2.02)</td><td align="left" valign="top">.60</td></tr><tr><td align="left" valign="top">&#x2003;Non-Hispanic Asian</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.39 (0.19&#x2010;0.80)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top">&#x2003;Hispanic/Latino</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">1.25 (0.66&#x2010;2.41)</td><td align="left" valign="top">.36</td></tr><tr><td align="left" valign="top" colspan="6">HCW<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup> location (reference: hospital)</td></tr><tr><td align="left" valign="top">&#x2003;Outpatient</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">1.55 (0.89&#x2010;2.71)</td><td align="left" valign="top">.12</td></tr><tr><td align="left" valign="top">&#x2003;Other/not working</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">1.05 (0.56&#x2010;1.98)</td><td align="left" valign="top">.88</td></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.46 (0.08&#x2010;2.82)</td><td align="left" valign="top">.40</td></tr><tr><td align="left" valign="top" colspan="6">Chronic MH<sup><xref ref-type="table-fn" rid="table2fn5">e</xref></sup> condition (reference: no MH)</td></tr><tr><td align="left" valign="top">&#x2003;Yes, MH condition</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">2.33 (1.35&#x2010;4.03)</td><td align="left" valign="top">.002</td></tr><tr><td align="left" valign="top" colspan="6">Political affiliation (reference: conservative)</td></tr><tr><td align="left" valign="top">&#x2003;Moderate</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">1.20 (0.54&#x2010;2.67)</td><td align="left" valign="top">.66</td></tr><tr><td align="left" valign="top">&#x2003;Liberal</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.58 (0.29&#x2010;1.14)</td><td align="left" valign="top">.11</td></tr><tr><td align="left" valign="top">&#x2003;Nonpolitical</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.70 (0.23&#x2010;2.17)</td><td align="left" valign="top">.54</td></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">1.41 (0.29&#x2010;6.96)</td><td align="left" valign="top">.67</td></tr><tr><td align="left" valign="top" colspan="6">Income level (reference: low income)</td></tr><tr><td align="left" valign="top">&#x2003;High income</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.51 (0.30&#x2010;0.87)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top" colspan="2">0.34 (0.10&#x2010;1.17)</td><td align="left" valign="top">.09</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>The logistic regression results showing associations between social media use (using our single latent variable from factor analysis) and anxiety symptoms. Model 1 includes only the exposure and outcome variables in the model, while model 2 includes sociodemographic variables. The reference group for each variable has been added in parentheses next to the variable name. The significance level for the <italic>P</italic> value was set &#x03B1; to .05.</p></fn><fn id="table2fn2"><p><sup>b</sup>OR: odds ratio.</p></fn><fn id="table2fn3"><p><sup>c</sup>Not applicable.</p></fn><fn id="table2fn4"><p><sup>d</sup>HCW: health care worker.</p></fn><fn id="table2fn5"><p><sup>e</sup>MH: mental health.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s2-9"><title>Ethical Considerations</title><p>This study used data from the UC-COVID Study, which was approved by the UCLA Institutional Review Board (IRB #20&#x2010;000683) and registered at ClinicalTrials.gov (NCT04373135). All participants in the original study provided informed consent via an online consent form prior to completing the baseline survey; this consent and the governing IRB protocol permitted secondary data analysis with deidentified data to protect participant confidentiality. Participants in the original study who provided an email address were entered into a gift card raffle, with entries awarded based on the completion of follow-up surveys. No additional compensation was provided for this secondary analysis. This manuscript and any supplementary materials do not include any images or figures depicting participants or identifiable individuals.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Missing Data Analysis</title><p>Both missing completely at random tests [<xref ref-type="bibr" rid="ref22">22</xref>] rejected the null hypothesis of missing completely at random (exposure/covariates: <italic>&#x03C7;</italic><sub>5</sub>&#x00B2;=22.5; <italic>P</italic>&#x003C;.001; outcome: <italic>&#x03C7;</italic><sub>12</sub>&#x00B2;=47.5; <italic>P</italic>&#x003C;.001); the large majority of missingness on these items (n=125, 98.4% for social media use) was attributable to survey noncompletion rather than item-level nonresponse, consistent with missing at random conditional on completion status (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p></sec><sec id="s3-2"><title>Frequency of Social Media Use by Platform</title><p><xref ref-type="table" rid="table1">Table 1</xref> shows the frequency of social media use across platforms. Twitter use was generally low, with more than half of participants reporting that they never used it for news (234/427, 54.8%). Instagram use was more evenly distributed, though over one-third reported never using it (152/427, 35.6%). Facebook had the highest levels of frequent engagement, with 32.6% (139/427) using it several times per day and another 21.3% (91/427) using it about once per day. In contrast, most participants reported never using other social media platforms (258/427, 60.4%). Use of other internet sites (eg, YouTube or TikTok) was more diffuse, with participants reporting use only a few times per week (78/427, 18.3%) or never (171/427, 40.1%). Participants most frequently listed LinkedIn, Reddit, Snapchat, TikTok, and YouTube as the other platforms that they commonly used (based on free-text responses).</p></sec><sec id="s3-3"><title>Factor Analysis Results</title><p><xref ref-type="table" rid="table3">Table 3</xref> shows the results of the factor analysis. All 5 social media use items demonstrated strong and statistically significant standardized factor loadings on the latent factor, with moderate coefficients ranging from 0.33 to 0.59. The highest loading was observed for other internet use (standardized loading=0.59; <italic>P</italic>&#x003C;.001). Model fit was acceptable (<italic>&#x03C7;</italic>&#x00B2;<sub>5</sub>=11.2; <italic>P</italic>=.047; Comparative Fit Index (CFI) 0.96, Tucker-Lewis Index (TLI) 0.91, root mean square error of approximation, RMSEA 0.05).</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Factor analysis of social media (SM) use variables<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup>.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="top">Variable</td><td align="left" valign="top">Factor loading (95% CI)</td><td align="left" valign="top">OIM<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup> SE</td><td align="left" valign="top"><italic>z</italic> score</td><td align="left" valign="top"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top">Twitter<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup></td><td align="left" valign="top">0.334 (0.216-0.451)</td><td align="left" valign="top">0.06</td><td align="left" valign="top">5.54</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">Instagram<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup></td><td align="left" valign="top">0.41 (0.302-0.535)</td><td align="left" valign="top">0.059</td><td align="left" valign="top">7.05</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">Facebook<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup></td><td align="left" valign="top">0.358 (0.242-0.474)</td><td align="left" valign="top">0.059</td><td align="left" valign="top">6.03</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">Other SM<sup><xref ref-type="table-fn" rid="table3fn6">f</xref></sup></td><td align="left" valign="top">0.54 (0.427-0.653)</td><td align="left" valign="top">0.058</td><td align="left" valign="top">9.36</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">Other internet<sup><xref ref-type="table-fn" rid="table3fn7">g</xref></sup></td><td align="left" valign="top">0.588 (0.474-0.702)</td><td align="left" valign="top">0.058</td><td align="left" valign="top">10.07</td><td align="left" valign="top">&#x003C;.001</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>The factor loadings and residual variances from a factor analysis of social media use variables. LR (Likelihood ratio) test of the model vs saturated: <italic>&#x03C7;</italic><sub>5</sub>&#x00B2;=11.2; <italic>P</italic>=.047. All factor loadings were statistically significant at <italic>P</italic> value &#x003C;.001.</p></fn><fn id="table3fn2"><p><sup>b</sup>OIM: Observed Information Matrix.</p></fn><fn id="table3fn3"><p><sup>c</sup>Residual variance: 0.889 (95% CI 0.813-0.971).</p></fn><fn id="table3fn4"><p><sup>d</sup>Residual variance: 0.825 (95% CI 0.733-0.928).</p></fn><fn id="table3fn5"><p><sup>e</sup>Residual variance: 0.872 (95% CI 0.792-0.959).</p></fn><fn id="table3fn6"><p><sup>f</sup>Residual variance: 0.709 (95% CI 0.597-0.842).</p></fn><fn id="table3fn7"><p><sup>g</sup>Residual variance: 0.654 (95% CI 0.533-0.804).</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-4"><title>Sample Characteristics</title><p><xref ref-type="table" rid="table4">Table 4</xref> shows the sample characteristics. HCWs were predominantly either medical doctors (MDs), doctors of osteopathic medicine (DOs), or advanced practice providers (APPs) at 35.6% (n=152) or registered nurses (RNs) or medical assistants (MAs; RNs/MAs) at 23.2% (n=99; <xref ref-type="table" rid="table4">Table 4</xref>). Clinical support service personnel (n=132, 30.9%) included HCWs identifying as respiratory therapists, physical therapists, or social workers, for example. Other HCWs (n=44, 10.3%) included primarily administrative HCWs and workers in adjacent health care settings (eg, veterinarians or dentists). The average age of HCWs was 44.3 (SD 13.5) years and HCWs were primarily female (n=314, 73.5%), Non-Hispanic white (n=262, 61.4%), had a bachelor&#x2019;s degree or more (n=390, 91.3%), household income of US $100,000 dollars and greater per year (n=246, 57.6%), liberal (n=239, 56.0%), and affiliated with a religion (n=270, 63.2%). Around 21.1% (n=90) of HCWs reported having a prior history of mental health condition diagnosis.</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>Health care worker (HCW) characteristics and anxiety symptoms (N=427)<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup>.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variable</td><td align="left" valign="bottom">Significant anxiety symptoms (GAD-2<sup><xref ref-type="table-fn" rid="table4fn2">b</xref></sup> &#x2265;3)</td><td align="left" valign="bottom">Nonsignificant anxiety symptoms</td><td align="left" valign="bottom">Total</td><td align="left" valign="bottom"><italic>P</italic> value<sup><xref ref-type="table-fn" rid="table4fn3">c</xref></sup></td></tr></thead><tbody><tr><td align="left" valign="top">Total, n (%)</td><td align="left" valign="top">125 (29.3)</td><td align="left" valign="top">302 (70.7)</td><td align="left" valign="top">427 (100)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Age (y), mean (SD)</td><td align="left" valign="top">40.3 (11.9)</td><td align="left" valign="top">46.0 (13.7)</td><td align="left" valign="top">44.3 (13.5)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top" colspan="4">Sex, n (%)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top">&#x2003;Male</td><td align="left" valign="top">40 (35.4)</td><td align="left" valign="top">73 (64.6)</td><td align="left" valign="top">113 (26.5)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Female</td><td align="left" valign="top">85 (27.1)</td><td align="left" valign="top">229 (72.9)</td><td align="left" valign="top">314 (73.5)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">HCW<sup><xref ref-type="table-fn" rid="table4fn4">d</xref></sup> type, n (%)</td><td align="left" valign="top">.16</td></tr><tr><td align="left" valign="top">&#x2003;MDs<sup><xref ref-type="table-fn" rid="table4fn5">e</xref></sup>, DOs<sup><xref ref-type="table-fn" rid="table4fn6">f</xref></sup>, and APPs<sup><xref ref-type="table-fn" rid="table4fn7">g</xref></sup></td><td align="left" valign="top">42 (27.6)</td><td align="left" valign="top">110 (72.4)</td><td align="left" valign="top">152 (35.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;RNs<sup><xref ref-type="table-fn" rid="table4fn8">h</xref></sup>/MAs<sup><xref ref-type="table-fn" rid="table4fn9">i</xref></sup></td><td align="left" valign="top">23 (23.2)</td><td align="left" valign="top">76 (76.8)</td><td align="left" valign="top">99 (23.2)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Clinical support services<sup><xref ref-type="table-fn" rid="table4fn10">j</xref></sup></td><td align="left" valign="top">48 (36.4)</td><td align="left" valign="top">84 (63.6)</td><td align="left" valign="top">132 (30.9)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Other HCWs<sup><xref ref-type="table-fn" rid="table4fn11">k</xref></sup></td><td align="left" valign="top">12 (27.3)</td><td align="left" valign="top">32 (72.7)</td><td align="left" valign="top">44 (10.3)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">HCW location, n (%)</td><td align="left" valign="top">.02</td></tr><tr><td align="left" valign="top">&#x2003;Hospital</td><td align="left" valign="top">50 (26.9)</td><td align="left" valign="top">136 (73.1)</td><td align="left" valign="top">186 (43.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Outpatient</td><td align="left" valign="top">46 (39.3)</td><td align="left" valign="top">71 (60.7)</td><td align="left" valign="top">117 (27.4)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Other/not working</td><td align="left" valign="top">27 (23.9)</td><td align="left" valign="top">86 (76.1)</td><td align="left" valign="top">113 (26.5)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">2 (18.2)</td><td align="left" valign="top">9 (81.8)</td><td align="left" valign="top">11 (2.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Race/ethnicity<sup><xref ref-type="table-fn" rid="table4fn12">l</xref></sup>, n (%)</td><td align="left" valign="top">.02</td></tr><tr><td align="left" valign="top">&#x2003;Non-Hispanic White</td><td align="left" valign="top">82 (31.3)</td><td align="left" valign="top">180 (68.7)</td><td align="left" valign="top">262 (61.4)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Non-Hispanic non-White</td><td align="left" valign="top">7 (26.9)</td><td align="left" valign="top">19 (73.1)</td><td align="left" valign="top">26 (6.1)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Non-Hispanic Asian</td><td align="left" valign="top">12 (15.6)</td><td align="left" valign="top">65 (84.4)</td><td align="left" valign="top">77 (18.0)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Hispanic/Latino</td><td align="left" valign="top">24 (38.7)</td><td align="left" valign="top">38 (61.3)</td><td align="left" valign="top">62 (14.5)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Education level, n (%)</td><td align="left" valign="top">.66</td></tr><tr><td align="left" valign="top">&#x2003;Less than a bachelor&#x2019;s degree</td><td align="left" valign="top">12 (32.4)</td><td align="left" valign="top">25 (67.6)</td><td align="left" valign="top">37 (8.7)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;A bachelor&#x2019;s degree or more</td><td align="left" valign="top">113 (29.0)</td><td align="left" valign="top">277 (71.0)</td><td align="left" valign="top">390 (91.3)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Income level, n (%)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">&#x2003;Annual household income less than 100,000</td><td align="left" valign="top">55 (45.8)</td><td align="left" valign="top">65 (54.2)</td><td align="left" valign="top">120 (28.1)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Annual household income of 100,000 or greater</td><td align="left" valign="top">56 (22.8)</td><td align="left" valign="top">190 (77.2)</td><td align="left" valign="top">246 (57.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">14 (23.0)</td><td align="left" valign="top">47 (77.0)</td><td align="left" valign="top">61 (14.3)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Political affiliation, n (%)</td><td align="left" valign="top">.004</td></tr><tr><td align="left" valign="top">&#x2003;Conservative</td><td align="left" valign="top">26 (44.8)</td><td align="left" valign="top">32 (55.2)</td><td align="left" valign="top">58 (13.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Moderate</td><td align="left" valign="top">26 (38.2)</td><td align="left" valign="top">42 (61.8)</td><td align="left" valign="top">68 (15.9)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Liberal</td><td align="left" valign="top">56 (23.4)</td><td align="left" valign="top">183 (76.6)</td><td align="left" valign="top">239 (56.0)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Nonpolitical</td><td align="left" valign="top">7 (29.2)</td><td align="left" valign="top">17 (70.8)</td><td align="left" valign="top">24 (5.6)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">10 (26.3)</td><td align="left" valign="top">28 (73.7)</td><td align="left" valign="top">38 (8.9)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Religious affiliation, n (%)</td><td align="left" valign="top">.10</td></tr><tr><td align="left" valign="top">&#x2003;Religious</td><td align="left" valign="top">87 (32.2)</td><td align="left" valign="top">183 (67.8)</td><td align="left" valign="top">270 (63.2)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Nonreligious</td><td align="left" valign="top">28 (23.9)</td><td align="left" valign="top">89 (76.1)</td><td align="left" valign="top">117 (27.4)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Missing</td><td align="left" valign="top">10 (25.0)</td><td align="left" valign="top">30 (75.0)</td><td align="left" valign="top">40 (9.4)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4">Mental health diagnosis, n (%)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top">&#x2003;Yes</td><td align="left" valign="top">36 (40.0)</td><td align="left" valign="top">54 (60.0)</td><td align="left" valign="top">90 (21.1)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;No</td><td align="left" valign="top">89 (26.4)</td><td align="left" valign="top">248 (73.6)</td><td align="left" valign="top">337 (78.9)</td><td align="left" valign="top"/></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>Participant characteristics across the entire sample and by their anxiety symptoms status based on GAD-2 scores (significant anxiety was reported if GAD-2 &#x2265;3). Column percentages are shown in the &#x201C;Total&#x201D; column, while row percentages are shown elsewhere. </p></fn><fn id="table4fn2"><p><sup>b</sup>GAD-2: Generalized Anxiety Disorder-2.</p></fn><fn id="table4fn3"><p><sup>c</sup>Significance level for <italic>P</italic> values was set to &#x03B1; of .05.</p></fn><fn id="table4fn4"><p><sup>d</sup>HCW: health care worker.</p></fn><fn id="table4fn5"><p><sup>e</sup>MDs: medical doctors.</p></fn><fn id="table4fn6"><p><sup>f</sup>DO: doctor of Osteopathic Medicine.</p></fn><fn id="table4fn7"><p><sup>g</sup>APP: advanced practice provider.</p></fn><fn id="table4fn8"><p><sup>h</sup>RN: registered nurse.</p></fn><fn id="table4fn9"><p><sup>i</sup>MA: medical assistant.</p></fn><fn id="table4fn10"><p><sup>j</sup>Clinical support services: respiratory therapists, physical therapists, and social workers, etc.</p></fn><fn id="table4fn11"><p><sup>k</sup>Other HCWs: administrative workers and HCWs in adjacent health care settings (ie, veterinarians or dentists).</p></fn><fn id="table4fn12"><p><sup>l</sup>Race and ethnicity were captured using a combined four&#x2011;level variable due to small group sizes: Non-Hispanic/White, Non-Hispanic/Non-White (including Black/African American, American Indian/Alaska Native, and multiracial), Non-Hispanic/Asian (including Asian and Native Hawaiian/Pacific Islander), and Hispanic/Latino.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-5"><title>Regression Models</title><p><xref ref-type="table" rid="table2">Table 2</xref> shows the regression models. The unadjusted odds of reporting anxiety were significantly higher among those with higher <italic>overall social media use</italic> (OR 1.77, CI 1.15&#x2010;2.73; <xref ref-type="table" rid="table2">Table 2</xref>). In the adjusted model, high social media use remained associated with higher odds of anxiety (adjusted odds ratio [aOR] 1.74, CI 1.08&#x2010;2.83). Older age was significantly associated with lower odds of anxiety (aOR 0.97, CI 0.95&#x2010;0.99). Non-Hispanic Asian HCWs were significantly less likely to report anxiety symptoms compared to their Non-Hispanic white counterparts (aOR 0.39, CI 0.19&#x2010;0.80). Reporting a chronic mental health condition was also associated with elevated odds of reporting anxiety symptoms (aOR 2.33, CI 1.35&#x2010;4.03). Participants reporting a higher level of income had significantly lower odds of anxiety symptoms compared to the lower income group (aOR 0.51, CI 0.30&#x2010;0.87).</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>Our findings suggest that greater social media use among HCWs was associated with elevated anxiety symptoms during the COVID-19 pandemic. These results highlight the potential mental health implications of social media use among HCWs and underscore the importance of understanding how digital platforms may influence psychological well-being in health care settings.</p><p>These findings are consistent with prior research demonstrating associations between media use, increased information exposure, and anxiety, depression, and psychological distress in the general population during the pandemic [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Recent studies have also shown that HCWs continued to experience substantial mental health challenges, including anxiety, emotional distress, and burnout, beyond the acute phase of the pandemic [<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref16">16</xref>]. At the same time, social media use plays an increasingly important role in information seeking, professional communication, and social connection among HCWs [<xref ref-type="bibr" rid="ref17">17</xref>]. Although digital platforms provide opportunities for education, networking, and support, evidence suggests that their effects on mental health and well-being may be complex [<xref ref-type="bibr" rid="ref25">25</xref>]. Our findings add to growing concerns regarding the potential mental health implications of social media use and extend the literature by linking social media use to anxiety symptoms among HCWs. Given the cross-sectional nature of this study and the limited assessment of the frequency of social media use, future research should use longitudinal designs and more detailed measures of social media use to better understand patterns of use, directionality, and relationships with mental health outcomes, potentially leveraging emerging AI and large language models to examine digital behaviors over time [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>].</p><p>In our analysis, older age was a protective factor for lessened anxiety symptoms, independent of social media use. Current literature has shown that younger adults experienced higher levels of anxiety, depression, and psychological distress during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. One reason for this finding is that older adults may possess more established coping strategies, greater emotional regulation, and increased resilience gained through life and professional experiences, which may help mitigate the psychological impact of stressful events [<xref ref-type="bibr" rid="ref15">15</xref>]. Continued research exploring the connection between age and anxiety while using social media is warranted.</p><p>The significant association between race and ethnicity and anxiety symptoms among HCWs highlights the importance of considering potential cultural and structural factors that impact vulnerable populations and mental health outcomes. Non-Hispanic Asian participants had significantly lower odds of reporting anxiety than their White counterparts. This finding is consistent with national US surveillance data showing that Asian adults report lower levels of anxiety symptoms than other racial/ethnic groups [<xref ref-type="bibr" rid="ref29">29</xref>]. Researchers have suggested that cultural differences in symptom expression, emotional restraint, stigma, and help-seeking behaviors may contribute to these observed differences [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>]. Larger studies examining diverse racial and ethnic groups will help provide a deeper understanding of the relationship between minoritized groups and anxiety symptoms.</p><p>Finally, having a mental health diagnosis was significantly associated with anxiety symptoms among HCWs. This finding is consistent with prior research demonstrating that HCWs experienced elevated rates of anxiety, depression, and psychological distress during the COVID-19 pandemic and that individuals with existing mental health conditions may be particularly vulnerable to worsening symptoms during periods of prolonged stress [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. One challenge with our finding is the nuance within the survey item. While the survey asked whether a previous mental health condition had been diagnosed, the ongoing medical management of the condition, including severity of the condition and medication use, was not assessed. These factors may influence the presence and severity of anxiety symptoms and could partially explain variation in outcomes. Future research should incorporate more comprehensive assessments of mental health history, treatment engagement, and other chronic health conditions to better understand how existing vulnerabilities influence psychological well-being among HCWs.</p><p>Higher income was associated with lower odds of anxiety symptoms when compared with the lower-income group, consistent with prior research demonstrating protective effects of financial stability on mental health [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>]. Access to resources, health care, and buffers against stressors may be contributing factors when considering this association. Reporting of income commonly has high item nonresponse rates, which may have contributed to missing income data [<xref ref-type="bibr" rid="ref35">35</xref>].</p></sec><sec id="s4-2"><title>Limitations</title><p>Limitations of this work include the cross-sectional nature of this analysis. One of the recruitment strategies for the UC-COVID Study included the use of social media platforms, which may have more readily recruited social media users. Although the survey asked participants about their frequency of social media use, it did not assess how participants engaged with social media sources (eg, what content is consumed), and further studies may be able to explore the details of how social media is used and the influence it may have on anxiety symptoms. Because missingness on our primary exposure and outcome was concentrated among participants who did not complete the survey, we cannot fully rule out that attrition itself relates to the underlying constructs of interest in a long, internet-administered survey. Our variables assessing social media use frequency should be interpreted cautiously and may not fully capture the underlying digital experiences contributing to anxiety symptoms, as prevalence of platform use may not represent actual user exposure that is shaped by personalized recommendations and engagement behaviors [<xref ref-type="bibr" rid="ref36">36</xref>]. These data were also collected during the COVID-19 pandemic, which may have influenced responses during a stressful time globally, but it alternatively represents a unique time point, a stressful situation that may similarly occur again in the future (ie, pandemics, epidemics, and natural disasters impacting health care). Questions regarding income, religion, and politics, which individuals may not want to disclose, may have contributed to some residual confounding. As the sample is not population-based, generalizability is limited. Additionally, some HCW groupings (eg, RNs/MAs) could not be disaggregated, limiting inferences that can be made from heterogeneous groups. Although the most used social media platforms (Facebook, Twitter, and Instagram) were individually assessed at the time of surveying participants, additional social media platforms should be individually assessed due to the rapidly changing landscape and increase in new platforms, as evidenced by our highest factor loading scores for other forms of social media use. Another challenge that exists is the limited data available regarding anxiety symptoms that can be captured with the GAD-2, and the GAD-7 may provide more specific detailed data for analyzing anxiety outcomes [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref37">37</xref>].</p></sec><sec id="s4-3"><title>Conclusion</title><p>Findings from this study highlight the multifactorial nature of anxiety symptoms in HCWs and suggest that social media use may be an important factor associated with psychological well-being in this population. Higher levels of social media use were associated with increased anxiety symptoms, even after adjusting for several sociodemographic characteristics. By capturing social media use as a single composite exposure across a sample of HCWs, rather than focusing on one platform or professional group, as in previous research, this study offers new insight into how social media use relates to HCWs&#x2019; anxiety symptoms. Social media use should be considered when identifying ways to support HCWs&#x2019; mental health. Attention may be warranted for younger HCWs, those with lower incomes, and individuals with preexisting mental health conditions, who may be more vulnerable to experiencing anxiety symptoms independent of social media use. Future research should further explore the mechanisms influencing these relationships and consider longitudinal approaches to understand fluctuations in a larger, diverse sample of HCWs and the trajectory of social media use and its impact on mental health in a postpandemic health care landscape.</p></sec></sec></body><back><ack><p>The authors thank the National Clinician Scholars Program (NCSP) at University of California, Los Angeles (UCLA) for providing the necessary resources to complete this secondary analysis. The authors also thank the UC-COVID Study&#x2019;s professional society and community partner organizations for helping to disseminate survey invitations. No generative AI tools were used for this manuscript.</p></ack><notes><sec><title>Funding</title><p>This project was supported by a contract from the University of California Office of the President (62165-RB) and the UCLA Clinical and Translational Science Institute (NIH/NCATS UL1TR001881). Dr. Buhr was additionally supported by a career development award from the UCLA CTSI (NIH/NCATS KL2 TR001882), a loan repayment program award (NIH/NHLBI L30HL130125), and a VA ORD (I01HX003939) award, outside the submitted work. Dr. Wisk was additionally supported by a career development award from the National Institutes of Health (NIH/NIDDK K01DK116932). The funding bodies had no role in the determination to publish nor the presentation of the findings in this manuscript.</p></sec><sec><title>Data Availability</title><p>The datasets generated or analyzed during this study are available from the corresponding author on reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: LEW, RGB</p><p>Data curation: LEW, RGB</p><p>Formal analysis: LEW, RGB, MP</p><p>Writing&#x2013;original draft: MP</p><p>Writing&#x2013;review and editing: LEW, RGB, MP, KC</p><p>All authors contributed meaningfully to the manuscript development and have reviewed the final manuscript.</p></fn><fn fn-type="conflict"><p>RB reports personal consulting fees from DynaMed/American College of Physicians and Optum and serving on an advisory board for Chiesi, unrelated to this work, and is an employee of the Veterans Health Administration. The views and positions in this manuscript do not necessarily reflect those of the Department of Veterans Affairs. The other authors declare no conflicts of interest.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">aOR</term><def><p>adjusted odds ratio</p></def></def-item><def-item><term id="abb2">APP</term><def><p>advanced practice provider</p></def></def-item><def-item><term id="abb3">CFA</term><def><p>confirmatory factor analysis</p></def></def-item><def-item><term id="abb4">CFI</term><def><p>Comparative Fit Index</p></def></def-item><def-item><term id="abb5">DO</term><def><p>doctor of osteopathic medicine</p></def></def-item><def-item><term id="abb6">GAD-2</term><def><p>Generalized Anxiety Disorder-2</p></def></def-item><def-item><term id="abb7">HCW</term><def><p>Health care worker</p></def></def-item><def-item><term id="abb8">IRB</term><def><p>Institutional Review Board</p></def></def-item><def-item><term id="abb9">MD</term><def><p>medical doctor</p></def></def-item><def-item><term id="abb10">medical assistant</term><def><p>medical assistant</p></def></def-item><def-item><term id="abb11">OR</term><def><p>odds ratio</p></def></def-item><def-item><term id="abb12">RMSEA</term><def><p>root mean square error of approximation</p></def></def-item><def-item><term id="abb13">RN</term><def><p>registered nurse</p></def></def-item><def-item><term id="abb14">TLI</term><def><p>Tucker-Lewis Index</p></def></def-item><def-item><term id="abb15">UCLA</term><def><p>University of California, Los Angeles</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="web"><article-title>Health workers face a mental health crisis</article-title><source>Centers for Disease Control and Prevention</source><year>2023</year><month>10</month><day>24</day><access-date>2026-04-16</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/vitalsigns/health-worker-mental-health/index.html">https://www.cdc.gov/vitalsigns/health-worker-mental-health/index.html</ext-link></comment></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bansal</surname><given-names>P</given-names> </name><name name-style="western"><surname>Bingemann</surname><given-names>TA</given-names> </name><name name-style="western"><surname>Greenhawt</surname><given-names>M</given-names> </name><etal/></person-group><article-title>Clinician wellness during the COVID-19 pandemic: extraordinary times and unusual challenges for the allergist/immunologist</article-title><source>J Allergy Clin Immunol Pract</source><year>2020</year><month>06</month><volume>8</volume><issue>6</issue><fpage>1781</fpage><lpage>1790</lpage><pub-id pub-id-type="doi">10.1016/j.jaip.2020.04.001</pub-id><pub-id pub-id-type="medline">32259628</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Weinstein</surname><given-names>A</given-names> </name><name name-style="western"><surname>Lejoyeux</surname><given-names>M</given-names> </name></person-group><article-title>Internet addiction or excessive internet use</article-title><source>Am J Drug Alcohol Abuse</source><year>2010</year><month>09</month><volume>36</volume><issue>5</issue><fpage>277</fpage><lpage>283</lpage><pub-id pub-id-type="doi">10.3109/00952990.2010.491880</pub-id><pub-id pub-id-type="medline">20545603</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Agarwal</surname><given-names>AK</given-names> </name><name name-style="western"><surname>Mittal</surname><given-names>J</given-names> </name><name name-style="western"><surname>Tran</surname><given-names>A</given-names> </name><name name-style="western"><surname>Merchant</surname><given-names>R</given-names> </name><name name-style="western"><surname>Guntuku</surname><given-names>SC</given-names> </name></person-group><article-title>Investigating social media to evaluate emergency medicine physicians&#x2019; emotional well-being during COVID-19</article-title><source>JAMA Netw Open</source><year>2023</year><month>05</month><day>1</day><volume>6</volume><issue>5</issue><fpage>e2312708</fpage><pub-id pub-id-type="doi">10.1001/jamanetworkopen.2023.12708</pub-id><pub-id pub-id-type="medline">37163264</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bhatti</surname><given-names>OA</given-names> </name><name name-style="western"><surname>Rauf</surname><given-names>H</given-names> </name><name name-style="western"><surname>Aziz</surname><given-names>N</given-names> </name><name name-style="western"><surname>Martins</surname><given-names>RS</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>JA</given-names> </name></person-group><article-title>Violence against healthcare workers during the COVID-19 pandemic: a review of incidents from a lower-middle-income country</article-title><source>Ann Glob Health</source><year>2021</year><month>04</month><day>23</day><volume>87</volume><issue>1</issue><fpage>41</fpage><pub-id pub-id-type="doi">10.5334/aogh.3203</pub-id><pub-id pub-id-type="medline">33977084</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Seddik</surname><given-names>SA</given-names> </name><name name-style="western"><surname>Abdelhai</surname><given-names>R</given-names> </name><name name-style="western"><surname>Aboushady</surname><given-names>AT</given-names> </name><name name-style="western"><surname>Nawwar</surname><given-names>AE</given-names> </name><name name-style="western"><surname>El Essawy</surname><given-names>RA</given-names> </name><name name-style="western"><surname>Hegazy</surname><given-names>AA</given-names> </name></person-group><article-title>Violence against healthcare workers during the COVID-19 pandemic: a cross-sectional survey at Cairo University Hospital</article-title><source>Front Public Health</source><year>2023</year><volume>11</volume><fpage>1277056</fpage><pub-id pub-id-type="doi">10.3389/fpubh.2023.1277056</pub-id><pub-id pub-id-type="medline">38045967</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Li</surname><given-names>W</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>AN</given-names> </name></person-group><article-title>Investigating the impacts of information overload on psychological well-being of healthcare professionals: role of COVID-19 stressor</article-title><source>Inquiry</source><year>2022</year><volume>59</volume><fpage>469580221109677</fpage><pub-id pub-id-type="doi">10.1177/00469580221109677</pub-id><pub-id pub-id-type="medline">35912469</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Farsi</surname><given-names>D</given-names> </name></person-group><article-title>Social media and health care, part I: literature review of social media use by health care providers</article-title><source>J Med Internet Res</source><year>2021</year><month>04</month><day>5</day><volume>23</volume><issue>4</issue><fpage>e23205</fpage><pub-id pub-id-type="doi">10.2196/23205</pub-id><pub-id pub-id-type="medline">33664014</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Montazeri</surname><given-names>A</given-names> </name><name name-style="western"><surname>Mohammadi</surname><given-names>S</given-names> </name><name name-style="western"><surname>Hesari</surname><given-names>PM</given-names></name><etal/></person-group><article-title>Exposure to the COVID-19 news on social media and consequent psychological distress and potential behavioral change</article-title><source>Sci Rep</source><year>2023</year><month>09</month><day>14</day><volume>13</volume><issue>1</issue><fpage>15224</fpage><pub-id pub-id-type="doi">10.1038/s41598-023-42459-6</pub-id><pub-id pub-id-type="medline">37710006</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Tezel</surname><given-names>A</given-names> </name><name name-style="western"><surname>Griffith</surname><given-names>KA</given-names> </name><name name-style="western"><surname>Jones</surname><given-names>RD</given-names> </name><name name-style="western"><surname>Jagsi</surname><given-names>R</given-names> </name></person-group><article-title>Diversity and representation of physicians during the COVID-19 news cycle</article-title><source>JAMA Intern Med</source><year>2021</year><month>01</month><day>1</day><volume>181</volume><issue>1</issue><fpage>124</fpage><lpage>127</lpage><pub-id pub-id-type="doi">10.1001/jamainternmed.2020.6285</pub-id><pub-id pub-id-type="medline">33315056</pub-id></nlm-citation></ref><ref id="ref11"><label>11</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Glasdam</surname><given-names>S</given-names> </name><name name-style="western"><surname>Sandberg</surname><given-names>H</given-names> </name><name name-style="western"><surname>Stjernsw&#x00E4;rd</surname><given-names>S</given-names> </name><name name-style="western"><surname>Jacobsen</surname><given-names>FF</given-names> </name><name name-style="western"><surname>Gr&#x00F8;nning</surname><given-names>AH</given-names> </name><name name-style="western"><surname>Hybholt</surname><given-names>L</given-names> </name></person-group><article-title>Nurses&#x2019; use of social media during the COVID-19 pandemic-A scoping review</article-title><source>PLoS One</source><year>2022</year><volume>17</volume><issue>2</issue><fpage>e0263502</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0263502</pub-id><pub-id pub-id-type="medline">35180264</pub-id></nlm-citation></ref><ref id="ref12"><label>12</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Huang</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Zhao</surname><given-names>N</given-names> </name></person-group><article-title>Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey</article-title><source>Psychiatry Res</source><year>2020</year><month>06</month><volume>288</volume><fpage>112954</fpage><pub-id pub-id-type="doi">10.1016/j.psychres.2020.112954</pub-id><pub-id pub-id-type="medline">32325383</pub-id></nlm-citation></ref><ref id="ref13"><label>13</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Xiong</surname><given-names>J</given-names> </name><name name-style="western"><surname>Lipsitz</surname><given-names>O</given-names> </name><name name-style="western"><surname>Nasri</surname><given-names>F</given-names> </name><etal/></person-group><article-title>Impact of COVID-19 pandemic on mental health in the general population: a systematic review</article-title><source>J Affect Disord</source><year>2020</year><month>12</month><day>1</day><volume>277</volume><fpage>55</fpage><lpage>64</lpage><pub-id pub-id-type="doi">10.1016/j.jad.2020.08.001</pub-id><pub-id pub-id-type="medline">32799105</pub-id></nlm-citation></ref><ref id="ref14"><label>14</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Gould</surname><given-names>LJ</given-names> </name><name name-style="western"><surname>Angwin</surname><given-names>E</given-names> </name><name name-style="western"><surname>Powell</surname><given-names>R</given-names> </name><name name-style="western"><surname>Lawrance</surname><given-names>E</given-names> </name></person-group><article-title>Healthcare workers&#x2019; mental health during the COVID-19 pandemic: a qualitative analysis of a text message-based NHS workforce support line</article-title><source>BMJ Open</source><year>2024</year><month>10</month><day>22</day><volume>14</volume><issue>10</issue><fpage>e084826</fpage><pub-id pub-id-type="doi">10.1136/bmjopen-2024-084826</pub-id><pub-id pub-id-type="medline">39438101</pub-id></nlm-citation></ref><ref id="ref15"><label>15</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Stanis&#x0142;awska-Kubiak</surname><given-names>M</given-names> </name><name name-style="western"><surname>Teusz</surname><given-names>G</given-names> </name><name name-style="western"><surname>Ziarko</surname><given-names>M</given-names> </name><name name-style="western"><surname>Mojs</surname><given-names>E</given-names> </name></person-group><article-title>Longitudinal insights into the mental health of healthcare workers: emotional shifts during two years of the COVID-19 crisis</article-title><source>Brain Sci</source><year>2024</year><month>11</month><day>19</day><volume>14</volume><issue>11</issue><fpage>1155</fpage><pub-id pub-id-type="doi">10.3390/brainsci14111155</pub-id><pub-id pub-id-type="medline">39595918</pub-id></nlm-citation></ref><ref id="ref16"><label>16</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lavell</surname><given-names>AHA</given-names> </name><name name-style="western"><surname>Sikkens</surname><given-names>JJ</given-names> </name><name name-style="western"><surname>Buis</surname><given-names>DTP</given-names> </name><etal/></person-group><article-title>Mental health of health care workers during and after the COVID-19 pandemic - a longitudinal cohort study</article-title><source>PLOS Ment Health</source><year>2025</year><volume>2</volume><issue>6</issue><fpage>e0000333</fpage><pub-id pub-id-type="doi">10.1371/journal.pmen.0000333</pub-id><pub-id pub-id-type="medline">41661990</pub-id></nlm-citation></ref><ref id="ref17"><label>17</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Engebretsen</surname><given-names>M</given-names> </name></person-group><article-title>The role, impact, and responsibilities of health experts on social media. A focus group study with future healthcare workers</article-title><source>Front Commun</source><year>2024</year><volume>9</volume><fpage>1296296</fpage><pub-id pub-id-type="doi">10.3389/fcomm.2024.1296296</pub-id></nlm-citation></ref><ref id="ref18"><label>18</label><nlm-citation citation-type="web"><article-title>Understanding community considerations, opinions, values, impacts, and decisions for COVID-19 (UC-COVID)</article-title><source>ClinicalTrials.gov</source><year>2025</year><month>01</month><day>30</day><access-date>2026-06-22</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/study/NCT04373135">https://clinicaltrials.gov/study/NCT04373135</ext-link></comment></nlm-citation></ref><ref id="ref19"><label>19</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wisk</surname><given-names>LE</given-names> </name><name name-style="western"><surname>Buhr</surname><given-names>RG</given-names> </name></person-group><article-title>Rapid deployment of a community engagement study and educational trial via social media: implementation of the UC-COVID study</article-title><source>Trials</source><year>2021</year><month>08</month><day>2</day><volume>22</volume><issue>1</issue><fpage>513</fpage><pub-id pub-id-type="doi">10.1186/s13063-021-05467-3</pub-id><pub-id pub-id-type="medline">34340693</pub-id></nlm-citation></ref><ref id="ref20"><label>20</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kroenke</surname><given-names>K</given-names> </name><name name-style="western"><surname>Spitzer</surname><given-names>RL</given-names> </name><name name-style="western"><surname>Williams</surname><given-names>JBW</given-names> </name><name name-style="western"><surname>Monahan</surname><given-names>PO</given-names> </name><name name-style="western"><surname>L&#x00F6;we</surname><given-names>B</given-names> </name></person-group><article-title>Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection</article-title><source>Ann Intern Med</source><year>2007</year><month>03</month><day>6</day><volume>146</volume><issue>5</issue><fpage>317</fpage><lpage>325</lpage><pub-id pub-id-type="doi">10.7326/0003-4819-146-5-200703060-00004</pub-id><pub-id pub-id-type="medline">17339617</pub-id></nlm-citation></ref><ref id="ref21"><label>21</label><nlm-citation citation-type="web"><article-title>QuickFacts: California</article-title><source>US Census Bureau</source><year>2021</year><access-date>2026-04-16</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.census.gov/quickfacts/fact/table/CA/INC110224">https://www.census.gov/quickfacts/fact/table/CA/INC110224</ext-link></comment></nlm-citation></ref><ref id="ref22"><label>22</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Little</surname><given-names>RJA</given-names> </name></person-group><article-title>A test of missing completely at random for multivariate data with missing values</article-title><source>J Am Stat Assoc</source><year>1988</year><month>12</month><volume>83</volume><issue>404</issue><fpage>1198</fpage><lpage>1202</lpage><pub-id pub-id-type="doi">10.1080/01621459.1988.10478722</pub-id></nlm-citation></ref><ref id="ref23"><label>23</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Thygesen</surname><given-names>H</given-names> </name><name name-style="western"><surname>Bonsaksen</surname><given-names>T</given-names> </name><name name-style="western"><surname>Schoultz</surname><given-names>M</given-names> </name><etal/></person-group><article-title>Social media use and its associations with mental health 9 months after the COVID-19 outbreak: a cross-national study</article-title><source>Front Public Health</source><year>2022</year><volume>9</volume><fpage>752004</fpage><pub-id pub-id-type="doi">10.3389/fpubh.2021.752004</pub-id><pub-id pub-id-type="medline">35118039</pub-id></nlm-citation></ref><ref id="ref24"><label>24</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lee</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Jeon</surname><given-names>YJ</given-names> </name><name name-style="western"><surname>Kang</surname><given-names>S</given-names> </name><name name-style="western"><surname>Shin</surname><given-names>JI</given-names> </name><name name-style="western"><surname>Jung</surname><given-names>YC</given-names> </name><name name-style="western"><surname>Jung</surname><given-names>SJ</given-names> </name></person-group><article-title>Social media use and mental health during the COVID-19 pandemic in young adults: a meta-analysis of 14 cross-sectional studies</article-title><source>BMC Public Health</source><year>2022</year><month>12</month><volume>22</volume><issue>1</issue><fpage>995</fpage><pub-id pub-id-type="doi">10.1186/s12889-022-13409-0</pub-id></nlm-citation></ref><ref id="ref25"><label>25</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ilola</surname><given-names>T</given-names> </name><name name-style="western"><surname>Malmisalo</surname><given-names>M</given-names> </name><name name-style="western"><surname>Laukka</surname><given-names>E</given-names> </name><etal/></person-group><article-title>The effectiveness of digital solutions in improving nurses&#x2019; and healthcare professionals&#x2019; mental well-being: a systematic review and meta-analysis</article-title><source>J Res Nurs</source><year>2024</year><month>03</month><volume>29</volume><issue>2</issue><fpage>97</fpage><lpage>109</lpage><pub-id pub-id-type="doi">10.1177/17449871241226914</pub-id><pub-id pub-id-type="medline">39070568</pub-id></nlm-citation></ref><ref id="ref26"><label>26</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Xie</surname><given-names>C</given-names> </name></person-group><article-title>Quantifying the interplay between panic propagation and misinformation on social media using large language models</article-title><source>Front Artif Intell Res</source><year>2026</year><volume>3</volume><issue>1</issue><fpage>1</fpage><lpage>8</lpage><pub-id pub-id-type="doi">10.71465/fair575</pub-id></nlm-citation></ref><ref id="ref27"><label>27</label><nlm-citation citation-type="other"><person-group person-group-type="author"><name name-style="western"><surname>Xie</surname><given-names>C</given-names> </name><name name-style="western"><surname>Zhu</surname><given-names>D</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Zhang</surname><given-names>H</given-names> </name><name name-style="western"><surname>Wei</surname><given-names>Z</given-names> </name></person-group><article-title>Explainable AI for mental health detection from social media: a comparative study of traditional machine learning and a large language model</article-title><source>SSRN</source><access-date>2026-07-23</access-date><comment>Preprint posted online on  Mar 14, 2026</comment><comment><ext-link ext-link-type="uri" xlink:href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6429778">https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6429778</ext-link></comment></nlm-citation></ref><ref id="ref28"><label>28</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Khalaf</surname><given-names>AM</given-names> </name><name name-style="western"><surname>Alubied</surname><given-names>AA</given-names> </name><name name-style="western"><surname>Khalaf</surname><given-names>AM</given-names> </name><name name-style="western"><surname>Rifaey</surname><given-names>AA</given-names> </name></person-group><article-title>The impact of social media on the mental health of adolescents and young adults: a systematic review</article-title><source>Cureus</source><year>2023</year><month>08</month><volume>15</volume><issue>8</issue><fpage>e42990</fpage><pub-id pub-id-type="doi">10.7759/cureus.42990</pub-id><pub-id pub-id-type="medline">37671234</pub-id></nlm-citation></ref><ref id="ref29"><label>29</label><nlm-citation citation-type="web"><article-title>Mental health and Asian Americans updated</article-title><source>Office of Minority Health, US Department of Health and Human Services</source><year>2025</year><access-date>2026-06-22</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://minorityhealth.hhs.gov/mental-and-behavioral-health-asian-americans">https://minorityhealth.hhs.gov/mental-and-behavioral-health-asian-americans</ext-link></comment></nlm-citation></ref><ref id="ref30"><label>30</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Liu</surname><given-names>H</given-names> </name><name name-style="western"><surname>Lieberman</surname><given-names>L</given-names> </name><name name-style="western"><surname>Stevens</surname><given-names>ES</given-names> </name><name name-style="western"><surname>Auerbach</surname><given-names>RP</given-names> </name><name name-style="western"><surname>Shankman</surname><given-names>SA</given-names> </name></person-group><article-title>Using a cultural and RDoC framework to conceptualize anxiety in Asian Americans</article-title><source>J Anxiety Disord</source><year>2017</year><month>05</month><volume>48</volume><fpage>63</fpage><lpage>69</lpage><pub-id pub-id-type="doi">10.1016/j.janxdis.2016.09.006</pub-id><pub-id pub-id-type="medline">27659553</pub-id></nlm-citation></ref><ref id="ref31"><label>31</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Terlizzi</surname><given-names>EP</given-names> </name><name name-style="western"><surname>Zablotsky</surname><given-names>B</given-names> </name></person-group><article-title>Symptoms of anxiety and depression among adults: United States, 2019 and 2022</article-title><source>Natl Health Stat Report</source><year>2024</year><month>11</month><day>7</day><issue>213</issue><fpage>CS353885</fpage><pub-id pub-id-type="doi">10.15620/cdc/64018</pub-id><pub-id pub-id-type="medline">39591466</pub-id></nlm-citation></ref><ref id="ref32"><label>32</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Thu Pham</surname><given-names>H</given-names> </name><name name-style="western"><surname>Viet Cao</surname><given-names>T</given-names> </name><name name-style="western"><surname>Bich Le</surname><given-names>N</given-names> </name><etal/></person-group><article-title>Depression, anxiety and stress among healthcare workers in the context of the COVID-19 pandemic: a cross-sectional study in a tertiary hospital in Northern Vietnam</article-title><source>Front Public Health</source><year>2023</year><volume>11</volume><fpage>1231326</fpage><pub-id pub-id-type="doi">10.3389/fpubh.2023.1231326</pub-id><pub-id pub-id-type="medline">37794894</pub-id></nlm-citation></ref><ref id="ref33"><label>33</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Thomson</surname><given-names>RM</given-names> </name><name name-style="western"><surname>Igelstr&#x00F6;m</surname><given-names>E</given-names> </name><name name-style="western"><surname>Purba</surname><given-names>AK</given-names> </name><etal/></person-group><article-title>How do income changes impact on mental health and wellbeing for working-age adults? A systematic review and meta-analysis</article-title><source>Lancet Public Health</source><year>2022</year><month>06</month><volume>7</volume><issue>6</issue><fpage>e515</fpage><lpage>e528</lpage><pub-id pub-id-type="doi">10.1016/S2468-2667(22)00058-5</pub-id><pub-id pub-id-type="medline">35660213</pub-id></nlm-citation></ref><ref id="ref34"><label>34</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Chan</surname><given-names>JK</given-names> </name><name name-style="western"><surname>Marzuki</surname><given-names>AA</given-names> </name><name name-style="western"><surname>Vafa</surname><given-names>S</given-names> </name><etal/></person-group><article-title>A systematic review on the relationship between socioeconomic conditions and emotional disorder symptoms during COVID-19: unearthing the potential role of economic concerns and financial strain</article-title><source>BMC Psychol</source><year>2024</year><month>04</month><day>26</day><volume>12</volume><issue>1</issue><fpage>237</fpage><pub-id pub-id-type="doi">10.1186/s40359-024-01715-8</pub-id><pub-id pub-id-type="medline">38671542</pub-id></nlm-citation></ref><ref id="ref35"><label>35</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Yan</surname><given-names>T</given-names> </name><name name-style="western"><surname>Curtin</surname><given-names>R</given-names> </name><name name-style="western"><surname>Jans</surname><given-names>M</given-names> </name></person-group><article-title>Trends in income nonresponse over two decades</article-title><source>J Off Stat</source><year>2010</year><access-date>2026-09-26</access-date><volume>26</volume><issue>1</issue><fpage>145</fpage><lpage>164</lpage><comment><ext-link ext-link-type="uri" xlink:href="https://www.scb.se/contentassets/ca21efb41fee47d293bbee5bf7be7fb3/trends-in-income-nonresponse-over-two-decades.pdf">https://www.scb.se/contentassets/ca21efb41fee47d293bbee5bf7be7fb3/trends-in-income-nonresponse-over-two-decades.pdf</ext-link></comment></nlm-citation></ref><ref id="ref36"><label>36</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hu</surname><given-names>Y</given-names> </name></person-group><article-title>Content prevalence is not adolescent exposure in TikTok influencer food marketing surveillance</article-title><source>Public Health Nutr</source><year>2026</year><month>02</month><day>26</day><volume>29</volume><issue>1</issue><fpage>e53</fpage><pub-id pub-id-type="doi">10.1017/S1368980026102213</pub-id><pub-id pub-id-type="medline">41742345</pub-id></nlm-citation></ref><ref id="ref37"><label>37</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Plummer</surname><given-names>F</given-names> </name><name name-style="western"><surname>Manea</surname><given-names>L</given-names> </name><name name-style="western"><surname>Trepel</surname><given-names>D</given-names> </name><name name-style="western"><surname>McMillan</surname><given-names>D</given-names> </name></person-group><article-title>Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis</article-title><source>Gen Hosp Psychiatry</source><year>2016</year><volume>39</volume><fpage>24</fpage><lpage>31</lpage><pub-id pub-id-type="doi">10.1016/j.genhosppsych.2015.11.005</pub-id><pub-id pub-id-type="medline">26719105</pub-id></nlm-citation></ref></ref-list><app-group><supplementary-material id="app1"><label>Multimedia Appendix 1 </label><p>Missing data analysis tables.</p><media xlink:href="jmir_v28i1e102008_app1.docx" xlink:title="DOCX File, 20 KB"/></supplementary-material></app-group></back></article>