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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e79109</article-id>
      <article-id pub-id-type="pmid">41072922</article-id>
      <article-id pub-id-type="doi">10.2196/79109</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Research Letter</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Research Letter</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>User Engagement, Demographics, and Health Status of the My ME-BYO Record, A Personal Health Management Mobile App: Retrospective Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
        <contrib contrib-type="editor">
          <name>
            <surname>Stone</surname>
            <given-names>Alicia</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kc</surname>
            <given-names>Sukriti</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Baker</surname>
            <given-names>Elizabeth</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Chei</surname>
            <given-names>Choy-Lye</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Cancer Prevention and Control Division</institution>
            <institution>Kanagawa Cancer Center Research Institute</institution>
            <addr-line>2-3-2 Nakao, Asahi-ku</addr-line>
            <addr-line>Yokohama, 241-8515</addr-line>
            <country>Japan</country>
            <fax>81 045 520 2202</fax>
            <phone>81 045 520 2222</phone>
            <email>clchei1123@gmail.com</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0008-7741-6465</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Nakamura</surname>
            <given-names>Sho</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5378-9477</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Watanabe</surname>
            <given-names>Kaname</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6155-5283</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Narimatsu</surname>
            <given-names>Hiroto</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0383-4911</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Cancer Prevention and Control Division</institution>
        <institution>Kanagawa Cancer Center Research Institute</institution>
        <addr-line>Yokohama</addr-line>
        <country>Japan</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Department of Genetic Medicine</institution>
        <institution>Kanagawa Cancer Center</institution>
        <addr-line>Yokohama</addr-line>
        <country>Japan</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Graduate School of Health Innovation</institution>
        <institution>Kanagawa University of Human Services</institution>
        <addr-line>Kawasaki</addr-line>
        <country>Japan</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Center for Innovation Policy</institution>
        <institution>Kanagawa University of Human Services</institution>
        <addr-line>Kawasaki</addr-line>
        <country>Japan</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Choy-Lye Chei <email>clchei1123@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>10</day>
        <month>10</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e79109</elocation-id>
      <history>
        <date date-type="received">
          <day>15</day>
          <month>6</month>
          <year>2025</year>
        </date>
        <date date-type="rev-request">
          <day>14</day>
          <month>8</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>25</day>
          <month>9</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>30</day>
          <month>9</month>
          <year>2025</year>
        </date>
      </history>
      <copyright-statement>©Choy-Lye Chei, Sho Nakamura, Kaname Watanabe, Hiroto Narimatsu. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 10.10.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e79109" xlink:type="simple"/>
      <abstract>
        <p>We outlined the characteristics and health status of individuals using a mobile health app, based on a real-world user database.</p>
      </abstract>
      <kwd-group>
        <kwd>mobile health application</kwd>
        <kwd>ME-BYO</kwd>
        <kwd>user engagement</kwd>
        <kwd>Japan</kwd>
        <kwd>real-world data</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>The ME-BYO concept, proposed by the Kanagawa Prefecture in Japan, emphasizes the intermediate “predisease” state (ME-BYO) in health management (<xref rid="figure1" ref-type="fig">Figure 1</xref>) [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. The My ME-BYO Record app, launched in 2017, records health and medication data and tracks physical activity. In 2020, the ME-BYO index was integrated to promote behavioral change by visualizing ME-BYO status (<xref rid="figure1" ref-type="fig">Figure 1</xref>) [<xref ref-type="bibr" rid="ref2">2</xref>]. Unlike many Japanese mobile health (mHealth) apps from private companies, this app is developed and managed by the local government. Most research on mHealth app use relies on surveys [<xref ref-type="bibr" rid="ref3">3</xref>], as developers rarely share app-collected data. We aimed to analyze user characteristics and health status using real-world data from the My ME-BYO Record app, with findings that may inform strategies to improve user engagement.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>The ME-BYO concept, the My ME-BYO Record application, and the ME-BYO index.</p>
        </caption>
        <graphic xlink:href="jmir_v27i1e79109_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>This study reports selected findings from a project commissioned by the Kanagawa Prefectural Government. Between April 1, 2020, and July 31, 2023, a cumulative total of 186,972 individuals registered as users; 10,239 aged ≥18 years who accessed the ME-BYO index at least once were included in the analysis.</p>
        <p>The ME-BYO index is a self-reported 15-item assessment of metabolic, locomotor, cognitive, and mental resilience domains. Scores range from 0 to 100, with higher scores indicating better health [<xref ref-type="bibr" rid="ref2">2</xref>] (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p>
        <p>Differences between 1-time and repeat users were tested using <italic>t</italic> tests (continuous variables) and chi-square tests (categorical variables). Logistic regression examined the association between engagement (1-time users as reference) and independent variables (sex, age, and domain scores). Analyses were performed using Stata 17 SE (StataCorp). Further details are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
      </sec>
      <sec>
        <title>Ethical Considerations</title>
        <p>This study was approved by the Institutional Review Board of the Kanagawa Cancer Center (2024Eki-108). Informed consent was waived as only anonymous data were analyzed. No compensation was offered. The My ME-BYO Record app is freely available, and users consent to the Kanagawa Prefectural Government’s Terms of Use upon registration [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>Of 10,239 users, 21.5% (n=2202) were repeat and 78.5% (n=8037) were 1-time users. Repeat users had significantly lower ME-BYO scores (<xref ref-type="table" rid="table1">Table 1</xref>). Logistic regression showed they were older, had lower cognitive function, and higher locomotor function than 1-time users (Table S1 in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Characteristics of My ME-BYO Record users (N=10,239) from April 2020 to July 2023, stratified by 1-time and repeat users.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="30"/>
          <col width="470"/>
          <col width="200"/>
          <col width="200"/>
          <col width="0"/>
          <col width="100"/>
          <thead>
            <tr valign="top">
              <td colspan="2">　Characteristic</td>
              <td colspan="3">ME-BYO index users</td>
              <td><italic>P</italic> value<sup>a</sup></td>
            </tr>
            <tr valign="top">
              <td colspan="2">
                <break/>
              </td>
              <td>1-time users<break/>(n=8037)</td>
              <td>Repeat users<break/>(n=2202)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td colspan="5">
                <bold>Sex, n (%)</bold>
              </td>
              <td>&#60;.001</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Women</td>
              <td>3966 (49.3)</td>
              <td>992 (45)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Men</td>
              <td>4071 (50.7)</td>
              <td>1210 (55)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="2">Age (years), mean (SD)</td>
              <td>52.4 (12.8)</td>
              <td>56.2 (11.7)</td>
              <td colspan="2">&#60;.001</td>
            </tr>
            <tr valign="top">
              <td colspan="5">
                <bold>Age group (years), n (%)</bold>
              </td>
              <td>&#60;.001</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>18-29</td>
              <td>441 (5.5)</td>
              <td>56 (2.5)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>30-39</td>
              <td>921 (11.5)</td>
              <td>138 (6.3)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>40-49</td>
              <td>1625 (20.2)</td>
              <td>361 (16.4)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>50-59</td>
              <td>2596 (32.3)</td>
              <td>744 (33.8)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>60-69</td>
              <td>1805 (22.5)</td>
              <td>636 (28.9)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>70-79</td>
              <td>575 (7.2)</td>
              <td>245 (11.1)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>≥80</td>
              <td>74 (0.9)</td>
              <td>22 (1)</td>
              <td colspan="2">
                <break/>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="2">ME-BYO score, mean (SD)</td>
              <td>84.1 (10)</td>
              <td>83.6 (10.1)</td>
              <td colspan="2">.02</td>
            </tr>
            <tr valign="top">
              <td colspan="2">Metabolic function, mean (SD)</td>
              <td>89.5 (11.4)</td>
              <td>89.1 (11.4)</td>
              <td colspan="2">.13</td>
            </tr>
            <tr valign="top">
              <td colspan="2">Locomotor function, mean (SD)</td>
              <td>83.6 (21.1)</td>
              <td>85.5 (19.8)</td>
              <td colspan="2">&#60;.001</td>
            </tr>
            <tr valign="top">
              <td colspan="2">Cognitive function, mean (SD)</td>
              <td>84.3 (23.3)</td>
              <td>80.8 (25)</td>
              <td colspan="2">&#60;.001</td>
            </tr>
            <tr valign="top">
              <td colspan="2">Mental resilience, mean (SD)</td>
              <td>63.4 (21.4)</td>
              <td>63.5 (21.5)</td>
              <td colspan="2">.97</td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn id="table1fn1">
            <p><sup>a</sup><italic>P</italic> values were calculated using the <italic>t</italic> test for continuous variables and the chi-square test for categorical variables.</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>Approximately 20% (n=2202) of users were repeat users, indicating repeat engagement with the ME-BYO index for health monitoring was low. Although engagement may increase over time, the Prefectural Government may struggle to incorporate the app into regional health strategies until such growth occurs.</p>
        <p>Repeat users were older than 1-time users. Users of mHealth apps supporting self-care and chronic disease monitoring also tend to be older than nonusers [<xref ref-type="bibr" rid="ref5">5</xref>]. Older individuals may view the free ME-BYO index feature as a useful tool for monitoring well-being, leading to repeat engagement [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>].</p>
        <p>Repeat users also had lower ME-BYO index scores, particularly in cognitive function. As the app displays the latest ME-BYO index score on the home screen, repeat users may be motivated by disappointment with low scores and continue using the app to improve them [<xref ref-type="bibr" rid="ref6">6</xref>]. Conversely, 1-time users might worry that subsequent scores would be worse. Lower cognitive ability has been associated with reduced mHealth access [<xref ref-type="bibr" rid="ref8">8</xref>], yet individuals with chronic conditions are more likely to use mHealth apps than those without [<xref ref-type="bibr" rid="ref9">9</xref>]. Our findings suggest that this app may help manage cognitive function in those with poorer cognitive abilities.</p>
        <p>Repeat users also had higher locomotor function scores. Physically active individuals are more likely to use mHealth apps to manage health behaviors [<xref ref-type="bibr" rid="ref9">9</xref>]. Similarly, those with better mobility may perceive the app as more useful for health monitoring, encouraging active engagement [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>First, most app users were aged older than 40 years, limiting the generalizability of our findings to younger age groups. Second, there is potential for reporting bias through self-report. Although the Mini-Cog and walking speed measures in the ME-BYO index have been validated [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>], other components still require validation. Third, the dataset lacked details such as disease comorbidities and socioeconomic status, which may affect user engagement. Including these confounders in future studies will improve the interpretation of the findings.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This study highlights a gap between 1-time and repeat engagement with the ME-BYO index for health monitoring. Using a real-world database, our findings may help inform strategies to improve engagement.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Additional materials on the ME-BYO index, data analysis, and Table S1.</p>
        <media xlink:href="jmir_v27i1e79109_app1.docx" xlink:title="DOCX File , 27 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>Data analysis was conducted by the authors as part of a project commissioned by the Kanagawa Prefectural Office. We thank Editage for English language editing.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>In accordance with the Act on the Protection of Personal Information, public disclosure of the data is restricted. For details regarding personal data protection and the use of anonymized data, please refer to the Kanagawa Prefectural website.</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>Writing—original draft: CLC</p>
        <p>Writing—review and editing: CLC, SN, KW, and HN</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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