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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e72658</article-id>
      <article-id pub-id-type="pmid">40939172</article-id>
      <article-id pub-id-type="doi">10.2196/72658</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A Design Framework for Microintervention Software Technology in Digital Health: Critical Interpretive Synthesis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Cahill</surname>
            <given-names>Naomi</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Breznen</surname>
            <given-names>Boris</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Amusa</surname>
            <given-names>Tope</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Persson</surname>
            <given-names>Dan Roland</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution/>
            <institution>Department of Computer Science</institution>
            <institution>University of Copenhagen</institution>
            <addr-line>Sigurdsgade 41</addr-line>
            <addr-line>Copenhagen N, 2200</addr-line>
            <country>Denmark</country>
            <phone>45 31393905</phone>
            <email>drpe@di.ku.dk</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4258-6949</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Ramasawmy</surname>
            <given-names>Mel</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4864-8565</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Khan</surname>
            <given-names>Nushrat</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4521-0920</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Banerjee</surname>
            <given-names>Amitava</given-names>
          </name>
          <degrees>DPhil</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8741-3411</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Blandford</surname>
            <given-names>Ann</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-3198-7122</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Bardram</surname>
            <given-names>Jakob Eyvind</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff7" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1390-8758</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Bækgaard</surname>
            <given-names>Per</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6720-1128</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Computer Science</institution>
        <institution>University of Copenhagen</institution>
        <addr-line>Copenhagen N</addr-line>
        <country>Denmark</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Department of Applied Mathematics and Computer Science</institution>
        <institution>Technical University of Denmark</institution>
        <addr-line>Kongens Lyngby</addr-line>
        <country>Denmark</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Institute of Health Informatics</institution>
        <institution>University College London</institution>
        <addr-line>London</addr-line>
        <country>United Kingdom</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Wolfson Institute of Population Health</institution>
        <institution>Queen Mary University of London</institution>
        <addr-line>London</addr-line>
        <country>United Kingdom</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>Department of Primary Care and Public Health</institution>
        <institution>Faculty of Medicine</institution>
        <institution>Imperial College London</institution>
        <addr-line>London</addr-line>
        <country>United Kingdom</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>University College London Interaction Centre</institution>
        <institution>University College London</institution>
        <addr-line>London</addr-line>
        <country>United Kingdom</country>
      </aff>
      <aff id="aff7">
        <label>7</label>
        <institution>Department of Health Technology</institution>
        <institution>Technical University of Denmark</institution>
        <addr-line>Kongens Lyngby</addr-line>
        <country>Denmark</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Dan Roland Persson <email>drpe@di.ku.dk</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>12</day>
        <month>9</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e72658</elocation-id>
      <history>
        <date date-type="received">
          <day>14</day>
          <month>2</month>
          <year>2025</year>
        </date>
        <date date-type="rev-request">
          <day>4</day>
          <month>6</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>9</day>
          <month>7</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>29</day>
          <month>7</month>
          <year>2025</year>
        </date>
      </history>
      <copyright-statement>©Dan Roland Persson, Mel Ramasawmy, Nushrat Khan, Amitava Banerjee, Ann Blandford, Jakob Eyvind Bardram, Per Bækgaard. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 12.09.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e72658" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Although many digital health interventions have been studied in human-computer interaction, long-term engagement remains a challenge. Microinterventions that leverage small but meaningful steps toward health outcomes have been proposed as a method for providing flexible and engaging, yet short and focused, interventions. One way to mitigate the potentially limiting scope of each microintervention is through narratives combining multiple different microinterventions over time to facilitate greater effects and engagement. As an emerging field of research, significant focus has thus far been placed on the creation and testing of individual microinterventions with little consideration for the consolidated experience, that is, the narrative over time. A more concise terminology and framework could make it easier to design, evaluate, and compare systems for microinterventions, facilitate collaboration in the field, and foster communication across required disciplines.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This paper aims to provide a framework for the creation of microintervention systems and the narratives served by these through their microinterventions.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>To synthesize a framework, we carried out a critical interpretive synthesis involving reciprocal translational analysis, refutational synthesis, and lines-of-argument synthesis, based on a systematic review of microintervention literature following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines across the Association for Computing Machinery Digital Library, PubMed, Scopus, and Web of Science. To assess the resulting framework, we applied it retroactively back onto the literature.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Based on a review including 35 studies, of which 80% (n=28) were published after 2020, we present and rationalize the Design for Microintervention Software Technology (D-MIST) framework, which can be used to better classify, design, and evaluate microinterventions. D-MIST defines a microintervention system on three levels: (1) the narrative, (2) the microintervention, and (3) the event. The narrative is the consolidated experience of engaging with multiple microinterventions over time, supporting a narrative goal, for example, a clinical goal. A microintervention is a highly focused intervention consisting of self-contained events aiming to facilitate small but meaningful steps toward the narrative goal. The event attempts a positive momentary change through a resource, for example, an exercise. Events may, for example, be designed for single use, present variations to facilitate engagement, or present order-dependent sequential resources. We additionally discuss supporting constructs, such as decision rules, conceptual models, and the system’s interaction model, that is, how the system interacts with the user through its design and other actors to create a consolidated narrative.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The resulting D-MIST framework, based on current state-of-the-art literature, describes the components of microintervention systems and how these contribute to a consolidated experience. Based hereon, we suggest opportunities for personalization of microintervention systems, discuss design guidelines, and the roles of actors in creating health narratives aiming to obtain better distal health outcomes.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>microinterventions</kwd>
        <kwd>narrative</kwd>
        <kwd>framework</kwd>
        <kwd>personalization</kwd>
        <kwd>digital health</kwd>
        <kwd>microintervention</kwd>
        <kwd>micro-interventions</kwd>
        <kwd>micro interventions</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Digitization has enabled many new approaches in digital health technology with a range of apps supporting mental and physical conditions [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref5">5</xref>]. Although many digital health interventions for managing health conditions have been designed and evaluated, there is growing evidence that long-term engagement is typically challenged, as also reflected by high attrition [<xref ref-type="bibr" rid="ref6">6</xref>-<xref ref-type="bibr" rid="ref8">8</xref>]. Reasons for this include gaps in (1) understanding how people fit digital interventions into their lives [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref9">9</xref>] and (2) making interventions personally and contextually relevant [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. Both issues address the core challenge of how digital interventions can remain engaging over time [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>] and hence are likely to have a meaningful long-term health outcome. Further, users may expect interventions to be quick and convenient [<xref ref-type="bibr" rid="ref12">12</xref>], suggesting a need for flexibility, contextual adaptation, and personalization [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>One approach to better fit digital interventions into everyday life is through the use of microinterventions, which are brief interventions aiming to have a positive effect on targeted symptoms [<xref ref-type="bibr" rid="ref14">14</xref>]. Microinterventions differ from traditional interventions by being short and highly focused [<xref ref-type="bibr" rid="ref14">14</xref>], delivered to help users achieve their goals [<xref ref-type="bibr" rid="ref12">12</xref>]. Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>], for example, used exercises, games, and videos to elicit momentary stress reductions upon user request. A shorter length aims to reduce barriers to initial and sustained engagement, meeting users’ often limited capacity or willingness to invest efforts into interventions [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>As an emerging field of research, significant emphasis has been placed on the investigation of selected microinterventions and their effects on targeted symptoms and measures. Studies in this domain have shown microinterventions to improve mood [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>], stress [<xref ref-type="bibr" rid="ref15">15</xref>], promote physical activity [<xref ref-type="bibr" rid="ref18">18</xref>], and support chronic illness [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. If digital interventions are to be both usable and (clinically) effective, they need to be evaluated over different timescales—both proximal and distal. Proximal outcomes are those that can be evaluated within a short timeframe (immediately or within hours), such as event effects [<xref ref-type="bibr" rid="ref12">12</xref>] and early engagement. Distal outcomes are those that can only be evaluated after an extended timeframe (weeks or months), including long-term engagement and changes in health outcomes.</p>
        <p>Given each microintervention’s relatively short and focused nature, the term “microintervention care” has been suggested as a way of describing the larger therapeutic process where several interventions are used in combination for a greater effect [<xref ref-type="bibr" rid="ref12">12</xref>]. To make microinterventions personally and contextually relevant, a key approach is to construct a narrative, which is an “account of connected events” [<xref ref-type="bibr" rid="ref21">21</xref>], combining several microinterventions. The true potential of microinterventions may be realized using these as building blocks for larger narratives, with individual microinterventions’ effects contributing to the narrative’s therapeutic goals rather than being purely isolated interventions. Schroeder et al [<xref ref-type="bibr" rid="ref22">22</xref>], for example, create a narrative of 5 microinterventions, each comprising several events, with a narrative goal to develop skills that help users maintain positive relationships. One included microintervention is “Emotional Regulation,” intended to help control emotions, in turn containing events like “Understand Emotions” and “Change Skills” [<xref ref-type="bibr" rid="ref22">22</xref>].</p>
        <p>However, when investigating the reported studies on microinterventions, it appears that the terminology involved in describing what constitutes microinterventions varies subtly or even significantly, with no unified definition of the terms, what microinterventions consist of, and how they are delivered. This hampers the design and optimization of microinterventions as part of technologies, while also making it more difficult to assess, evaluate, and compare which microintervention components are most effective and under what circumstances. Thus, while it is possible to assess and compare the outcome of a microintervention on an overall level, it is difficult to understand what components of the microintervention made the difference. Often, such digital health intervention studies are treated as a “black box,” where it is difficult to precisely see what constitutes the intervention. For example, if comparing two different smoking cessation studies, one showing better results than the other, it would be relevant to investigate and define exactly which components of the intervention actually were behind the two approaches, including what health narrative was used, which specific microintervention steps were suggested, and how the effect of such intervention steps was assessed and used.</p>
        <p>A common terminology is essential in order to understand, discuss, and compare microintervention studies, thereby promoting interdisciplinary collaboration and communication [<xref ref-type="bibr" rid="ref23">23</xref>]. Researchers could also benefit from a better and more precise understanding of the complex literature [<xref ref-type="bibr" rid="ref24">24</xref>], including available building blocks, collections, or “catalogs” of interventions, their events, and when to best make use of these. Moreover, an improved understanding of the user experience may positively impact the uptake and efficacy of such microinterventions.</p>
      </sec>
      <sec>
        <title>Related Work</title>
        <sec>
          <title>Microinterventions</title>
          <p>Research on microinterventions as a specific field of study has been steadily increasing in recent years. Modern interest in microinterventions within computer science seems to have picked up from 2014, with early works [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] such as that by Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>], describing a system recommending contextually relevant microinterventions from a library of 16 possible microinterventions. Outside the field of computer science, the term microintervention has seen use by, for example, Wetzel [<xref ref-type="bibr" rid="ref25">25</xref>] and Rinne et al [<xref ref-type="bibr" rid="ref26">26</xref>]. Rinne et al [<xref ref-type="bibr" rid="ref26">26</xref>] used the term to denote “brief activities conducted by teachers in which the presentation of numerical information is preceded and/or followed by particular exercises that scaffold students’ decision-making procedures,” although variations of this definition can also be found elsewhere [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>].</p>
          <p>In 2019, Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>] provided a broad definition of what microinterventions are, and in 2020, Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>] further conceptualized the idea of “microintervention care” as consisting of narratives of microinterventions facilitated by a “hub,” for example, a digital app or coach [<xref ref-type="bibr" rid="ref12">12</xref>]. Arguably, works both prior to and after Fuller-Tyszkiewicz et al’s [<xref ref-type="bibr" rid="ref14">14</xref>] definition can be classified as microintervention systems. For example, Quinn et al [<xref ref-type="bibr" rid="ref29">29</xref>] describe a system providing feedback messages from a library of 1000, similar to the approaches used in recent microintervention systems [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Other systems have used microinterventions to reduce sedentary time [<xref ref-type="bibr" rid="ref31">31</xref>], motivate short exercise sessions [<xref ref-type="bibr" rid="ref32">32</xref>], provide personalized feedback [<xref ref-type="bibr" rid="ref33">33</xref>], or reduce stress through breathing exercises [<xref ref-type="bibr" rid="ref34">34</xref>]. Outside of health and well-being, the term microintervention has also seen some use in game research [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>].</p>
        </sec>
        <sec>
          <title>Intervention Patterns and Microinterventions</title>
          <p>Generally, microinterventions use previously established and grouped behavior change techniques (BCTs) [<xref ref-type="bibr" rid="ref37">37</xref>] such as shaping knowledge [<xref ref-type="bibr" rid="ref38">38</xref>], comparisons of outcomes [<xref ref-type="bibr" rid="ref39">39</xref>], and feedback and monitoring [<xref ref-type="bibr" rid="ref20">20</xref>]. Many proposed microinterventions use multiple different BCTs [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] in line with commercially deployed app-interventions [<xref ref-type="bibr" rid="ref41">41</xref>]. More broadly, digital technologies aiming to support behavior change are referred to as digital behavior change interventions (DBCIs) [<xref ref-type="bibr" rid="ref8">8</xref>]. Various frameworks and models supporting DBCIs development have been suggested, such as the Just-In-Time Adaptive Interventions (JITAI) framework [<xref ref-type="bibr" rid="ref23">23</xref>]. Mohr et al’s [<xref ref-type="bibr" rid="ref42">42</xref>] BIT model provides a framework for articulating the relationship between intervention aims, characteristics, workflow, and implementation. However, prior works have also noted some difficulty in translating BCTs to a digital context, particularly regarding engagement [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. Fulton et al [<xref ref-type="bibr" rid="ref43">43</xref>] suggest co-design or cocreation [<xref ref-type="bibr" rid="ref44">44</xref>] as a means of improving engagement. Mummah et al’s [<xref ref-type="bibr" rid="ref45">45</xref>] “IDEAS” DBCI design framework highlights empathizing with users before attempting to ground desired target behaviors in behavioral theory.</p>
          <p>In the past decade, many intervention designs have been conceptualized, proposed, and explored. According to Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>], microinterventions, just-in-time (JIT), JITAI, and ecological momentary interventions (EMIs) may be differentiated from standard intervention packages in terms of the depth of content and timing of content delivery. Heron and Smyth [<xref ref-type="bibr" rid="ref46">46</xref>] describe EMI as: “...provid[ing] a framework for treatments characterized by the delivery of interventions to people as they go about their daily lives.” JITAI has previously been described as consisting of two concepts: JIT and adaptive [<xref ref-type="bibr" rid="ref23">23</xref>]. JIT “is used to describe an attempt to provide the right type (or amount) of support, at the right time, namely neither too early nor too late” and “adaptation is defined as the use of ongoing (dynamic) information about the individual to modify the type, amount, and timing of support” (Nahum-Shani et al [<xref ref-type="bibr" rid="ref23">23</xref>]).</p>
          <p>Microinterventions can be differentiated from other designs by their exclusive focus on shorter and more focused interventions that can be “quickly” consumed and have an immediate impact on targeted symptoms [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Broadly, microinterventions aim to meet users’ often limited capacity or willingness to invest effort in beneficial therapeutics [<xref ref-type="bibr" rid="ref12">12</xref>]. Microinterventions, in particular, can be differentiated from the JITAIs described by Nahum-Shani et al [<xref ref-type="bibr" rid="ref23">23</xref>] in that these often rely on users’ subjective judgment rather than more well-defined protocols handled by systems. As such, many key constructs described by Nahum-Shani et al [<xref ref-type="bibr" rid="ref23">23</xref>], like “Just-in-time support,” “Adaptation,” “Intervention options,” and “Decision rules,” are neither used broadly nor universally present.</p>
          <p>While digital microinterventions are generally EMIs [<xref ref-type="bibr" rid="ref47">47</xref>] and overlap with JIT and JITAI in the sense that some systems use these patterns [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref23">23</xref>], this is not universally the case. Some microintervention systems allow users to choose when and which microintervention to engage with [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref48">48</xref>], counter to JITAIs, where decisions are based on the intervention protocol, and to JIT, as interventions are not necessarily deployed at the right time [<xref ref-type="bibr" rid="ref23">23</xref>]. Further, while JITAIs may include increasing or decreasing intensity or transitioning to other therapy types [<xref ref-type="bibr" rid="ref11">11</xref>], microinterventions, given their short, highly focused nature, may result in users not receiving interventions for periods of time [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Objective</title>
        <p>This paper aims to provide a framework for the creation of microintervention systems and the narratives served by these through their microinterventions. This framework is intended to be an evidence-based conceptual framework for classifying, designing, and studying microinterventions in digital health technologies that address different health conditions. The framework is useful for designers and researchers wishing to build or study microintervention systems. The framework is based on a review of the literature and the critical interpretive synthesis (CIS) method [<xref ref-type="bibr" rid="ref24">24</xref>]. The main contribution is the Design for Microintervention Software Technology (D-MIST) conceptual framework for the design and assessment of microintervention technology. This framework defines the core components of microintervention systems and provides a classification using concepts, evidence, and examples from the reviewed literature. The framework defines core concepts like the “microintervention system,” “narrative,” “microintervention,” and “event.” The framework can help design and evaluate microintervention technology by providing more precise and evidence-based definitions. Based on the D-MIST framework, we discuss the role of actors in the decision-making process, personalization, and present a catalog of microinterventions.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>Development of the D-MIST framework is based on the CIS method [<xref ref-type="bibr" rid="ref24">24</xref>]. This approach was motivated by several factors: CIS offers an alternative to a standard systematic review, which usually focuses on producing an aggregative overview of literature by instead creating an interpretive synthesis [<xref ref-type="bibr" rid="ref24">24</xref>]. CIS is particularly useful in this case as key characteristics (concepts or components) are not well specified nor used consistently in the literature. Prior to this work, for example, no definition existed for “microintervention systems,” including the system’s role, with the term “microintervention” seeing varied uses in the literature [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] with some works suggesting these are each one piece of content attempting change [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref49">49</xref>] and others seeing each microintervention as consisting of one or multiple events [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Through its exploratory and interpretive nature, CIS supports the development of concepts and theories: in this case, framework development using induction and interpretation [<xref ref-type="bibr" rid="ref24">24</xref>]. This flexibility also accommodates and indeed encourages including diverse study types [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]; this is also useful given the early-stage nature of microintervention research that includes many design, feasibility, and pilot studies with relatively short study durations and limited participants.</p>
        <p>One limitation of the CIS methodology is that it does not include a formal search protocol; accordingly, we have followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [<xref ref-type="bibr" rid="ref52">52</xref>]. However, the focus of this paper is not on providing a systematic aggregate overview of the literature, but rather on presenting the synthesized framework, including a narrative overview of the literature, which leads to the framework rationale.</p>
      </sec>
      <sec>
        <title>Review</title>
        <sec>
          <title>Search Strategy</title>
          <p>This work is scoped on the literature, which uses the term “microintervention.” This avoided us imposing a definition of “microintervention” and “microintervention system.” Moreover, we wanted to avoid limiting the initial search results to a certain context, that is, “mHealth” or “digital health,” to capture the broadest possible view on the subject area. The search terms used were: “micro intervention” OR “micro-intervention” OR “micro interventions” OR “micro-interventions.” The full search strategy can be found in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
          <p>Four databases were searched: the Association for Computing Machinery (ACM) digital library, Scopus, PubMed, and Web of Science—all databases well suited for this type of conceptual synthesis [<xref ref-type="bibr" rid="ref53">53</xref>]. The search fields for ACM, PubMed, and Web of Science were “all fields” (“anywhere” on ACM); for SCOPUS, it was limited to “Article Title, Abstract, and Keywords.” No filters were applied to any database.</p>
        </sec>
        <sec>
          <title>Eligibility Criteria</title>
          <p>Inclusion criteria were: (1) a peer-reviewed journal study or conference paper, (2) written in English, (3) describing the implementation of at least one microintervention or key components of such, (4) targeting adults, and (5) relating to mental or physical health or well-being. Studies were excluded if (1) they did not focus on health or well-being, (2) participants were nonadults, or (3) the paper did not describe the implementation of at least one microintervention or key components of these. Moreover, (4) non-English texts and (5) papers such as reviews, protocols, opinion pieces, commentaries, perspectives, and books were removed.</p>
        </sec>
        <sec>
          <title>Study Selection</title>
          <p>The documented review and analysis were conducted on June 10, 2024, and were subsequently validated on November 11, 2024, by two authors. Duplicates were removed by the first author. Screening of records by title and abstract was conducted independently by two authors, with an adjudication process used for disagreements, which included discussion and rereviewing. Full-text screening against inclusion or exclusion criteria was conducted by one author, with an additional author cross-checking these.</p>
        </sec>
        <sec>
          <title>Data Extraction</title>
          <p>Data extraction initially consisted of overall study characteristics extracted into an Excel (Microsoft Corp) template, for example, paper type, targets, users, and duration. Additional data extraction consisted of document highlighting, paragraph extraction, and thematic organization in line with the CIS approach [<xref ref-type="bibr" rid="ref24">24</xref>], eventually resulting in the framework itself and additional extraction of microinterventions, event types, number of events, and used resources (eg, text or video) based on the framework.</p>
        </sec>
        <sec>
          <title>Quality Appraisal</title>
          <p>As noted in the motivation for our methodological approach, we did not omit any studies based on quality issues and accordingly did not use any structured tool to appraise studies.</p>
        </sec>
      </sec>
      <sec>
        <title>CIS</title>
        <p>Following the approach presented by Dixon-Woods et al [<xref ref-type="bibr" rid="ref24">24</xref>], three of the authors engaged in the CIS approach involving three strategies: (1) reciprocal translational analysis, (2) refutational synthesis, and (3) lines-of-argument synthesis.</p>
        <p>(1) In our reciprocal translational analysis, key definitions, descriptions, and uses were initially identified, compared, and translated into one another. Maps and initial models were created based on the presented descriptions and uses. (2) In refutational synthesis, contradictions between descriptions were identified and attempts were made to explain these through the available literature, including a critical and reflexive approach to the literature insights and scrutinizing arguments, evidence, and theory. (3) In lines-of-argument, we built our initial framework interpretation based on findings from the literature and prior phases. This included integrating evidence from across studies into a coherent framework and generating new “synthetic constructs” (components). These components are grounded in evidence and result from an overall interpretation of available evidence, allowing different definitions and uses to be unified. Our framework section on microinterventions, for example, presents an argument synthesis for a unified definition of microinterventions based on previous definitions, uses, and other components.</p>
        <p>The validity of the synthesis is based on the CIS approach, by retroactively applying the framework back onto the literature and through the experience of the research team, which covers multiple disciplines, including human-computer interaction, user experience, computer science, and (digital) health. The process spanned two countries and included multiple levels of seniority and experience in both academia and industry.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Selection and Characteristics</title>
        <p>The PRISMA diagram [<xref ref-type="bibr" rid="ref52">52</xref>] of the selection process is shown in <xref rid="figure1" ref-type="fig">Figure 1</xref>. <xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table2">2</xref> provide an overview and breakdown of the included literature. Of the 384 retrieved records, 198 records were screened after removing duplicates. Following title or abstract screening, 151 records were excluded, leaving 47 for full-text review; of these, 4 could not be retrieved, and 8 were excluded based on full-text screening.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram for June 10, showing the study’s inclusion process. ACM: Association for Computing Machinery Digital Library; WOS: Web of Science.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e72658_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Overview of studies included in the review, ordered by microintervention target and year of publication.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="150"/>
            <col width="60"/>
            <col width="140"/>
            <col width="140"/>
            <col width="140"/>
            <col width="90"/>
            <col width="60"/>
            <col width="90"/>
            <col width="130"/>
            <thead>
              <tr valign="top">
                <td>Author</td>
                <td>Year</td>
                <td>Paper type</td>
                <td>Microintervention targets</td>
                <td>Microintervention users</td>
                <td>Participants (n)</td>
                <td>Days</td>
                <td>Outcome</td>
                <td>Digital (platform)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>]</td>
                <td>2023</td>
                <td>RT<sup>a</sup> (4 groups)</td>
                <td>Stress</td>
                <td>Adults</td>
                <td>462</td>
                <td>28</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Johnson et al [<xref ref-type="bibr" rid="ref55">55</xref>]</td>
                <td>2022</td>
                <td>RT (3 groups)</td>
                <td>Stress</td>
                <td>Adults</td>
                <td>1050</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                <td>2022</td>
                <td>Pilot (3 groups)</td>
                <td>Stress</td>
                <td>Information workers</td>
                <td>86</td>
                <td>28</td>
                <td>Positive</td>
                <td>Yes (desktop and smartphone)</td>
              </tr>
              <tr valign="top">
                <td>de Witte et al [<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                <td>2022</td>
                <td>Development</td>
                <td>Stress</td>
                <td>All</td>
                <td>0</td>
                <td>0</td>
                <td>N/A<sup>b</sup></td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Gummidela et al [<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                <td>2021</td>
                <td>Mixed experiments</td>
                <td>Shallow breathing (stress and anxiety)</td>
                <td>Adults</td>
                <td>66</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Peeters et al [<xref ref-type="bibr" rid="ref59">59</xref>]</td>
                <td>2020</td>
                <td>Pilot (3 groups)</td>
                <td>Stress (work-family conflict)</td>
                <td>Working mothers</td>
                <td>360</td>
                <td>7-28</td>
                <td>Partly positive</td>
                <td>Yes (web-based and smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Clarke et al [<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                <td>2017</td>
                <td>Design</td>
                <td>Stress</td>
                <td>Adults</td>
                <td>0</td>
                <td>0</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
                <td>2014</td>
                <td>Pilot (4 groups)</td>
                <td>Stress</td>
                <td>All (adults)</td>
                <td>95</td>
                <td>28</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Dainer-Best and Rubin [<xref ref-type="bibr" rid="ref61">61</xref>]</td>
                <td>2024</td>
                <td>RT (6 groups)</td>
                <td>Mood and anxiety</td>
                <td>Adults</td>
                <td>350</td>
                <td>1-7</td>
                <td>Negative</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Bunge et al [<xref ref-type="bibr" rid="ref17">17</xref>]</td>
                <td>2023</td>
                <td>RT (3 groups)</td>
                <td>Mood</td>
                <td>Adults</td>
                <td>838</td>
                <td>7</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Frank et al [<xref ref-type="bibr" rid="ref20">20</xref>]</td>
                <td>2022</td>
                <td>RT (2 groups)</td>
                <td>Depression, mood, and anxiety</td>
                <td>Adults</td>
                <td>135</td>
                <td>112</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>2022</td>
                <td>RT (2 groups)</td>
                <td>Mood and motivation</td>
                <td>Adults</td>
                <td>838</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Everitt et al [<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                <td>2021</td>
                <td>RT (4 groups)</td>
                <td>Mood</td>
                <td>All (adults)</td>
                <td>235</td>
                <td>21-51</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Meinlschmidt et al [<xref ref-type="bibr" rid="ref63">63</xref>]</td>
                <td>2020</td>
                <td>Pilot (2 groups)</td>
                <td>Mood</td>
                <td>Adults (men)</td>
                <td>31</td>
                <td>13</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Meinlschmidt et al [<xref ref-type="bibr" rid="ref48">48</xref>]</td>
                <td>2016</td>
                <td>Pilot (2 groups)</td>
                <td>QoL<sup>c</sup> (mood)</td>
                <td>Adults (men)</td>
                <td>31</td>
                <td>13</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Matthews et al [<xref ref-type="bibr" rid="ref19">19</xref>]</td>
                <td>2014</td>
                <td>Pilot</td>
                <td>Mood and well-being</td>
                <td>Bipolar disorder</td>
                <td>3</td>
                <td>21-28</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Davies et al [<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                <td>2024</td>
                <td>Design</td>
                <td>Body satisfaction</td>
                <td>Young women</td>
                <td>212</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Herriman et al [<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                <td>2024</td>
                <td>Pilot</td>
                <td>Body satisfaction</td>
                <td>Adults</td>
                <td>112</td>
                <td>1-7</td>
                <td>Positive</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Nemesure et al [<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td>2023</td>
                <td>Feasibility</td>
                <td>Body dissatisfaction</td>
                <td>Adults</td>
                <td>525</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Fardouly et al [<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                <td>2023</td>
                <td>RT (3 groups)</td>
                <td>Body dissatisfaction</td>
                <td>Young women</td>
                <td>221</td>
                <td>14-42</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Fraser et al [<xref ref-type="bibr" rid="ref68">68</xref>]</td>
                <td>2022</td>
                <td>RT (3 groups)</td>
                <td>Body dissatisfaction</td>
                <td>Young women</td>
                <td>176</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Gobin et al [<xref ref-type="bibr" rid="ref69">69</xref>]</td>
                <td>2022</td>
                <td>RT (2 groups)</td>
                <td>Body dissatisfaction</td>
                <td>Young women</td>
                <td>260</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
                <td>2019</td>
                <td>RT (2 groups)</td>
                <td>Body satisfaction</td>
                <td>Women</td>
                <td>247</td>
                <td>21</td>
                <td>Positive</td>
                <td>Yes (smartphone and web-based)</td>
              </tr>
              <tr valign="top">
                <td>Persson et al [<xref ref-type="bibr" rid="ref70">70</xref>]</td>
                <td>2024</td>
                <td>RT (3 groups)</td>
                <td>Multifaceted<sup>d</sup></td>
                <td>Adults</td>
                <td>208</td>
                <td>21</td>
                <td>Negative</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Xu et al [<xref ref-type="bibr" rid="ref71">71</xref>]</td>
                <td>2024</td>
                <td>Case study</td>
                <td>Multifaceted<sup>d</sup></td>
                <td>N/A</td>
                <td>4</td>
                <td>1</td>
                <td>Positive</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Pascoe et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td>
                <td>2022</td>
                <td>Feasibility</td>
                <td>Multifaceted<sup>d</sup></td>
                <td>Adults</td>
                <td>255</td>
                <td>196</td>
                <td>Negative</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Sun et al [<xref ref-type="bibr" rid="ref72">72</xref>]</td>
                <td>2024</td>
                <td>RT (2 groups)</td>
                <td>Hypertension (blood pressure and healthy behaviors)</td>
                <td>Adults</td>
                <td>68</td>
                <td>84</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Persson et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>2023</td>
                <td>Feasibility</td>
                <td>Physical activity and healthy diet motivation</td>
                <td>Adults</td>
                <td>14</td>
                <td>14</td>
                <td>Negative</td>
                <td>Yes (smartphone)</td>
              </tr>
              <tr valign="top">
                <td>Wahl et al [<xref ref-type="bibr" rid="ref73">73</xref>]</td>
                <td>2022</td>
                <td>Feasibility</td>
                <td>Compulsive handwashing</td>
                <td>OCD<sup>e</sup></td>
                <td>21</td>
                <td>1</td>
                <td>Feasible</td>
                <td>Yes (smartwatch)</td>
              </tr>
              <tr valign="top">
                <td>Vandesande et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>2022</td>
                <td>Pilot</td>
                <td>Parent self-efficacy</td>
                <td>Parents of children with disabilities</td>
                <td>16</td>
                <td>21</td>
                <td>Partly positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Malouff and Johnson [<xref ref-type="bibr" rid="ref74">74</xref>]</td>
                <td>2020</td>
                <td>RT (2 groups)</td>
                <td>Unpleasant dreams</td>
                <td>Adults</td>
                <td>126</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Van Cappellen et al [<xref ref-type="bibr" rid="ref49">49</xref>]</td>
                <td>2020</td>
                <td>RT (4 groups)</td>
                <td>Enjoyment and motivation to engage in meditation</td>
                <td>Adults (midlife)</td>
                <td>240</td>
                <td>21</td>
                <td>Positive</td>
                <td>Partly (Ipod)</td>
              </tr>
              <tr valign="top">
                <td>Conroy et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td>
                <td>2019</td>
                <td>Feasibility</td>
                <td>Promote PA<sup>f</sup> and reduce sedentary time</td>
                <td>Adults</td>
                <td>11</td>
                <td>112</td>
                <td>Positive</td>
                <td>Yes (phone)</td>
              </tr>
              <tr valign="top">
                <td>Fink-Lamotte et al [<xref ref-type="bibr" rid="ref75">75</xref>]</td>
                <td>2023</td>
                <td>RT (3 groups)</td>
                <td>Social anxiety and shame</td>
                <td>Adults</td>
                <td>115</td>
                <td>1</td>
                <td>Positive</td>
                <td>Yes (web-based)</td>
              </tr>
              <tr valign="top">
                <td>Kivity and Huppert [<xref ref-type="bibr" rid="ref76">76</xref>]</td>
                <td>2016</td>
                <td>Diary study (3 groups)</td>
                <td>Social anxiety</td>
                <td>Adults (high social anxiety)</td>
                <td>124</td>
                <td>5-9</td>
                <td>Positive</td>
                <td> Parly (web-based)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>RT: randomized trial.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>Not applicable.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>QoL: quality of life.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>Interventions with several targets, for example, stress and physical activity.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>OCD: obsessive-compulsive disorder.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>PA: physical activity.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Catalog of microinterventions, event types, the number of events, and resources used by the included studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="150"/>
            <col width="350"/>
            <col width="200"/>
            <col width="100"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Author</td>
                <td>Microinterventions</td>
                <td>Event types</td>
                <td>Events</td>
                <td>Resources</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>]</td>
                <td>Positive psychology, cognitive behavioral, meta-cognitive, and somatic</td>
                <td>Single, repetition, variations, and adaptive</td>
                <td>160</td>
                <td>Text, URL</td>
              </tr>
              <tr valign="top">
                <td>Johnson et al [<xref ref-type="bibr" rid="ref55">55</xref>]</td>
                <td>Relaxation, response modulation, positive experiences, and resource buffers</td>
                <td>Single</td>
                <td>17</td>
                <td>Video, text</td>
              </tr>
              <tr valign="top">
                <td>Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                <td>“get my mind off work,” “feel calm and present,” “think through my stress”</td>
                <td>Variations, repetitions</td>
                <td>3</td>
                <td>Videos, chatbot conversation, and activity suggestion</td>
              </tr>
              <tr valign="top">
                <td>de Witte et al [<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                <td>Music therapy</td>
                <td>Variations</td>
                <td>2</td>
                <td>Therapist facilitation</td>
              </tr>
              <tr valign="top">
                <td>Gummidela et al [<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                <td>Game biofeedback, visual feedback, game with pacing, pacing</td>
                <td>Repetitions</td>
                <td>4</td>
                <td>Game, visual, or audio feedback</td>
              </tr>
              <tr valign="top">
                <td>Peeters et al [<xref ref-type="bibr" rid="ref59">59</xref>]</td>
                <td>“Use your resources” and “Count your blessings”</td>
                <td>Repetitions</td>
                <td>2</td>
                <td>Email, text</td>
              </tr>
              <tr valign="top">
                <td>Clarke et al [<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                <td>Positive psychology, cognitive behavioral, meta-cognitive, and somatic</td>
                <td>Repetitions</td>
                <td>18</td>
                <td>Apps</td>
              </tr>
              <tr valign="top">
                <td>Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
                <td>Positive psychology, cognitive behavioral, meta-cognitive, and somatic</td>
                <td>Repetitions, single</td>
                <td>16</td>
                <td>Text, URL to web apps</td>
              </tr>
              <tr valign="top">
                <td>Dainer-Best and Rubin [<xref ref-type="bibr" rid="ref61">61</xref>]</td>
                <td>Psychoeducation, 5-minute behavioral video, brief behavioral game, brief neutral game, video + behavioral game, video + neutral game</td>
                <td>Single</td>
                <td>5</td>
                <td>Game, audio, video, text, exercises, feedback</td>
              </tr>
              <tr valign="top">
                <td>Bunge et al [<xref ref-type="bibr" rid="ref17">17</xref>]</td>
                <td>Behavioral activation exercise, reminders, psychoeducation</td>
                <td>Single, variations, and repetitions</td>
                <td>2</td>
                <td>Text, exercise</td>
              </tr>
              <tr valign="top">
                <td>Frank et al [<xref ref-type="bibr" rid="ref20">20</xref>]</td>
                <td>Personalized messages, psychoeducation</td>
                <td>Variations, repetitions</td>
                <td>12+</td>
                <td>Text, imagery</td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>Behavioral activation (scheduling exercise)</td>
                <td>Single</td>
                <td>1</td>
                <td>Text, exercise</td>
              </tr>
              <tr valign="top">
                <td>Everitt et al [<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                <td>Mindfulness exercise, relaxation exercise</td>
                <td>Repetition</td>
                <td>4</td>
                <td>Audio exercise</td>
              </tr>
              <tr valign="top">
                <td>Meinlschmidt et al [<xref ref-type="bibr" rid="ref63">63</xref>]</td>
                <td>Viscerosensory attention, emotional imagery, facial expression, contemplative repetition</td>
                <td>Single, repetition</td>
                <td>4</td>
                <td>Short video clip</td>
              </tr>
              <tr valign="top">
                <td>Meinlschmidt et al [<xref ref-type="bibr" rid="ref48">48</xref>]</td>
                <td>Viscerosensory attention, emotional imagery, facial expression, and contemplative repetition</td>
                <td>Repetitions</td>
                <td>4</td>
                <td>Text, videos, audio</td>
              </tr>
              <tr valign="top">
                <td>Matthews et al [<xref ref-type="bibr" rid="ref19">19</xref>]</td>
                <td>Visualized digest</td>
                <td>Repetitions</td>
                <td>1+</td>
                <td>Visualization</td>
              </tr>
              <tr valign="top">
                <td>Davies et al [<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                <td>Appearance-related self-compassion, humorous or factual messages</td>
                <td>Single</td>
                <td>15</td>
                <td>Text, imagery</td>
              </tr>
              <tr valign="top">
                <td>Herriman et al [<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                <td>Psychoeducation, thought challenge, and written interactive task</td>
                <td>Single, adaptive</td>
                <td>1</td>
                <td>Video, exercise</td>
              </tr>
              <tr valign="top">
                <td>Nemesure et al [<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td>Minicourse (questions, feedback, exercises, psychoeducation)</td>
                <td>Single</td>
                <td>1</td>
                <td>Chatbot, text, exercises, feedback</td>
              </tr>
              <tr valign="top">
                <td>Fardouly et al [<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                <td>Social media posts (eg, body diversity, body acceptance, and kindness)</td>
                <td>Single, variations, and repetitions</td>
                <td>42</td>
                <td>Text, imagery</td>
              </tr>
              <tr valign="top">
                <td>Fraser et al [<xref ref-type="bibr" rid="ref68">68</xref>]</td>
                <td>Gratitude meditation, mindfulness meditation</td>
                <td>Single</td>
                <td>2</td>
                <td>Audio guide</td>
              </tr>
              <tr valign="top">
                <td>Gobin et al [<xref ref-type="bibr" rid="ref69">69</xref>]</td>
                <td>Self-compassion</td>
                <td>Single</td>
                <td>1</td>
                <td>Written task</td>
              </tr>
              <tr valign="top">
                <td>Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
                <td>Gratitude task, breathing, and relaxation</td>
                <td>Variations, repetitions</td>
                <td>11</td>
                <td>Videos (education and exercises)</td>
              </tr>
              <tr valign="top">
                <td>Persson et al [<xref ref-type="bibr" rid="ref70">70</xref>]</td>
                <td>Self-guided generation task, audio-based projection, image-based projection</td>
                <td>Variation, repetitions</td>
                <td>6</td>
                <td>Audio, text, imagery, exercises</td>
              </tr>
              <tr valign="top">
                <td>Xu et al [<xref ref-type="bibr" rid="ref71">71</xref>]</td>
                <td>Movement-based interventions, for example, dance and calligraphy</td>
                <td>Single</td>
                <td>4</td>
                <td>Phone call</td>
              </tr>
              <tr valign="top">
                <td>Pascoe et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td>
                <td>Psychoeducation, exercises, general education</td>
                <td>Variations, repetitions</td>
                <td>22+</td>
                <td>Web-based (videoconference)</td>
              </tr>
              <tr valign="top">
                <td>Sun et al [<xref ref-type="bibr" rid="ref72">72</xref>]</td>
                <td>Education, persuasion, incentivization, training, environmental restructuring, enablement</td>
                <td>Single, repetition, variations, and adaptive</td>
                <td>12+</td>
                <td>Video, text, exercises, imagery</td>
              </tr>
              <tr valign="top">
                <td>Persson et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>Self-guided generation task, audio-based projection, Image-based projection</td>
                <td>Variation, repetitions</td>
                <td>3</td>
                <td>Audio, text, imagery, exercises</td>
              </tr>
              <tr valign="top">
                <td>Wahl et al [<xref ref-type="bibr" rid="ref73">73</xref>]</td>
                <td>N/A<sup>a</sup></td>
                <td>N/A</td>
                <td>0</td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>Vandesande et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>Psychoeducation</td>
                <td>Sequence</td>
                <td>4</td>
                <td>Video series</td>
              </tr>
              <tr valign="top">
                <td>Malouff and Johnson [<xref ref-type="bibr" rid="ref74">74</xref>]</td>
                <td>Vivid recall of positive events</td>
                <td>Single</td>
                <td>1</td>
                <td>Text</td>
              </tr>
              <tr valign="top">
                <td>Van Cappellen et al [<xref ref-type="bibr" rid="ref49">49</xref>]</td>
                <td>Loving-kindness meditation, or mindfulness, and educational passage</td>
                <td>Single, sequence, and repetitions</td>
                <td>4</td>
                <td>Text (educational), audio (exercise)</td>
              </tr>
              <tr valign="top">
                <td>Conroy et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td>
                <td>Motivational, educational, or action messages</td>
                <td>Variations</td>
                <td>456</td>
                <td>Text</td>
              </tr>
              <tr valign="top">
                <td>Fink-Lamotte et al [<xref ref-type="bibr" rid="ref75">75</xref>]</td>
                <td>Self-compassion, cognitive reappraisal, and a control intervention</td>
                <td>Single</td>
                <td>3</td>
                <td>Audio</td>
              </tr>
              <tr valign="top">
                <td>Kivity and Huppert [<xref ref-type="bibr" rid="ref76">76</xref>]</td>
                <td>Reappraisal, reminders</td>
                <td>Repetitions</td>
                <td>2</td>
                <td>Reappraisal training (in-person), text</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Not applicable.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>The majority (28/35, 80%) of the studies included were published after 2020, highlighting an increasing interest in microinterventions. Little under half of the included studies (16/35, 46%) describe forms of randomized trials, with the other half (19/35, 54%) primarily pilot, developmental, or feasibility studies. A common trend among studies (13/35, 37%) is the focus on in-moment effects, limiting study duration: often less than one day. More long-term studies (18/35, 51%) generally lasted 7-31 days, except for 4 (11%) studies lasting 84-196 days [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. The number of participants varied significantly across studies, between 0 and 1050 participants. In the study with 0 participants, microinterventions were based on existing literature and were reviewed by a group of experts rather than potential end users [<xref ref-type="bibr" rid="ref57">57</xref>]. The events presented, that is, the unique attempts at positive momentary change, were generally relatively low, ranging between 1 and 18 (30/35, 86%), with notable exceptions of 0 and 456 events. Although the paper by Wahl et al [<xref ref-type="bibr" rid="ref73">73</xref>] does not present any events or microinterventions, it is included in the review due to its focus on when to deploy these (JIT recognition, ie, a component of a microintervention) rather than which microintervention or event should be used. The paper by Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>] is not formally included in the review as it does not implement any microinterventions or components (inclusion criterion 3) but rather theorizes on the structure of microinterventions. The constructs and definitions presented by the paper were, however, included in the CIS process as they were foundational for a number of the included papers [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]; no similar papers have been found nor excluded as part of the review process.</p>
      </sec>
      <sec>
        <title>The D-MIST Framework</title>
        <sec>
          <title>Overview</title>
          <p>This section presents the D-MIST framework, including its components and their rationale. The framework and its components are described and exemplified using the included literature on microinterventions (listed in <xref ref-type="table" rid="table1">Table 1</xref>), with a consolidated description of their components sorted by key concepts. The D-MIST framework is a synthesis of the reviewed literature, including Fuller-Tyszkiewicz et al’s [<xref ref-type="bibr" rid="ref14">14</xref>] definition of microinterventions, Baumel et al’s [<xref ref-type="bibr" rid="ref12">12</xref>] conceptualization of microintervention care, and other uses seen in the literature. The framework aims to unify these—at times disparate—concepts into a single framework with concrete evidence-based definitions.</p>
          <p>The D-MIST framework is illustrated in <xref rid="figure2" ref-type="fig">Figure 2</xref> with the constituent concepts defined in <xref ref-type="table" rid="table3">Table 3</xref>. The framework defines a microintervention system on three levels: (1) the overall narrative level, (2) the microintervention level, and (3) the event level. The overall effects are measured through the narrative effect, which is the sum of its constituent microintervention effects. The microintervention effect is, in turn, the sum of the event effects.</p>
          <p>The narrative is the consolidated experience of engaging with multiple microinterventions and their events over time, aiming to accomplish an overall narrative goal, for example, a clinical goal. The microintervention is a highly focused intervention consisting of one or more in-moment events of a given type, each attempting a positive effect. In this way, microinterventions can be seen as self-contained programs of events aiming to facilitate small but meaningful effects, in support of the microintervention effect and, in turn, the narrative effect. The event is the delivery of a resource, for example, an exercise or educational video, aiming for an immediate positive effect. An event may, depending on its type, do different things: present variations of an exercise to maintain engagement over time; be designed for repeated use, or be part of a sequence of logically ordered events.</p>
          <fig id="figure2" position="float">
            <label>Figure 2</label>
            <caption>
              <p>The Design Framework for Microintervention Software Technology (D-MIST) framework of microintervention systems with three levels: (A) narrative, (B) microintervention, and (C) event. At each level, there are different effects. The narrative focuses on the distal perspective and is encountered by the user through a number of microinterventions, each of which has its own effect. Each microintervention contains one or more events that focus on the immediate or proximal perspective.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e72658_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <table-wrap position="float" id="table3">
            <label>Table 3</label>
            <caption>
              <p>Definitions of microintervention systems and their core components.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="350"/>
              <col width="650"/>
              <thead>
                <tr valign="top">
                  <td>Components</td>
                  <td>Definitions</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>Microintervention system</td>
                  <td>The microintervention system, through its design and interaction model, aims to facilitate (1) the creation and maintenance of a narrative, (2) by serving relevant microinterventions, and (3) through recognition of the user’s situation, context, and needs.</td>
                </tr>
                <tr valign="top">
                  <td>Interaction model</td>
                  <td>The interaction model formalizes how the aims of the system are achieved through the user’s interactions with the system (eg, JIT<sup>a</sup> and on-demand) and other actors (eg, health coaches and other users).</td>
                </tr>
                <tr valign="top">
                  <td>Narrative</td>
                  <td>A narrative aims to address a clinical goal by creating a meaningful, connected story through its microinterventions and the events as experienced by the user.</td>
                </tr>
                <tr valign="top">
                  <td>Narrative thread</td>
                  <td>The narrative thread is the list of experienced microinterventions through their corresponding events, where each step is determined by the users’ circumstances and the best-fitting conceptual model.</td>
                </tr>
                <tr valign="top">
                  <td>Microintervention</td>
                  <td>A microintervention is a highly focused type of therapy relying on one or more events of a given type, each attempting some momentary change.</td>
                </tr>
                <tr valign="top">
                  <td>Conceptual models</td>
                  <td>Conceptual models describe the conditions for when and where a microintervention is relevant and can be used as part of a narrative.</td>
                </tr>
                <tr valign="top">
                  <td>Event</td>
                  <td>An event provides resources as required by its intended types and therapeutic groups, with an immediate positive effect on target attributes.</td>
                </tr>
                <tr valign="top">
                  <td>Decision rules</td>
                  <td>Decision rules determine which events should be triggered, the intensity of the event, and the conditions under which they should be triggered (eg, contextual factors, time of day, or user’s state).</td>
                </tr>
                <tr valign="top">
                  <td>Type</td>
                  <td>The event type refers to the way the event is used. Events can be classified as single-use, repeated, varied, sequential, or adaptive.</td>
                </tr>
                <tr valign="top">
                  <td>Resource</td>
                  <td>Each resource provides a piece of content (eg, a video, exercise, or call to action) in various formats, aiming to facilitate an immediate positive effect on target attributes.</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table3fn1">
                <p><sup>a</sup>JIT: just-in-time.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
          <p>A microintervention system may, for example, consist of a smartphone app with the intended effect (narrative goal) of improving sleep. The narrative might then consist of a sequence of microinterventions with their own intended effects (microintervention goals; eg, avoiding nightly screen time, mindfulness, and stress reduction) which through a number of events with their intended effects (event goals; eg, a video on the effects of nightly screen time, calls to action, and relaxation exercises) deliver various educational video and exercise resources.</p>
          <p>A microintervention system aims to create and maintain a narrative through recognition of a user’s situation and needs. In practice, these aims are accomplished through the interaction model formalizing how the users interact with the system (eg, JIT and on-demand) and other actors (eg, other users and health coaches). An on-demand system allows users to choose which microinterventions and events to engage with and when to do so. Other system designs may have a general practitioner or the system itself influence which microinterventions users engage with, perhaps through automated recognition of the user’s situation, context, and needs.</p>
          <p>The selection of microinterventions is supported by conceptual models detailing conditions for when a microintervention is relevant. In JIT- or JITAI-like systems, these conditions are explicit, detailed, and operational. They may alternatively be implicit from a design perspective when users are allowed to choose their microinterventions.</p>
          <p>Once a microintervention is chosen, the constituent events are typically deployed either randomly or through more specific decision rules such as time of day or time since last event [<xref ref-type="bibr" rid="ref56">56</xref>]. These decision rules may also be explicit or implicit. In on-demand systems, users may consume events at their own pace [<xref ref-type="bibr" rid="ref22">22</xref>] or all at once, while JIT-type systems may have explicit operational rules allowing precise contextual deployment.</p>
          <p>Applying the D-MIST framework to the system presented by Frank et al [<xref ref-type="bibr" rid="ref20">20</xref>] (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]), we see the system as a smartphone app enabling feature monitoring, self-assessment, psychoeducation, and delivery of personalized microinterventions with the narrative goal of improving mood. In practice, this is accomplished through an interaction model consisting of the system, clinician, and end user. The system facilitates data collection, allowing clinicians to identify needs and suggest relevant microinterventions, which users receive through the smartphone app. Users can then consume or reject suggested microinterventions, forming a collaboratively tailored narrative thread. While the study [<xref ref-type="bibr" rid="ref20">20</xref>] does not explicitly report on provided narratives or conceptual models, examples suggest microinterventions did not always target mood directly: for instance, one microintervention goal was to improve sleeping habits, with the event goal being to reduce nightly exposure to smartphone light.</p>
          <p>Looking at other examples from the literature, we could imagine narratives targeting mood to include interventions such as behavioral activation [<xref ref-type="bibr" rid="ref17">17</xref>] and relaxation exercises [<xref ref-type="bibr" rid="ref62">62</xref>]. Moreover, based on the work of Malouff and Johnson [<xref ref-type="bibr" rid="ref74">74</xref>], events aiming to reduce unpleasant dreams could also improve sleeping habits.</p>
          <p>However, as noted in the introduction, it is difficult to evaluate which leveraged microinterventions and events made a difference if these are treated as a part of a “black box.” Some users may, for instance, not benefit from improved sleeping habits, making these components irrelevant in such cases. Instead, using D-MIST’s levels to describe microintervention systems not only allows designers a means of reporting on individual narrative threads but also allows descriptions of each used microintervention, their events, and when these may be used in a narrative. <xref ref-type="supplementary-material" rid="app2">Multimedia Appendices 2</xref> [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] and <xref ref-type="supplementary-material" rid="app3">3</xref> map a number of other component examples. In the following subsections, we will provide a narrative overview of the literature and rationalize the framework, followed by a short overview of efficacy and user experience insights from the included literature.</p>
        </sec>
        <sec>
          <title>Microintervention System</title>
          <p>Among the systems included in our literature review (<xref ref-type="table" rid="table1">Table 1</xref>), most are fully digital (31/35, 89%), with smartphones (14/35, 40%) and web-based apps (18/35, 51%) being the most used platforms. Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>] describe three overall ways of interacting with microinterventions: JIT, prescheduling, and on-demand. JIT refers to the system choosing the intervention time [<xref ref-type="bibr" rid="ref62">62</xref>], the intervention [<xref ref-type="bibr" rid="ref15">15</xref>], or both [<xref ref-type="bibr" rid="ref56">56</xref>]. Prescheduling systems allow users to choose interventions ahead of time or to choose an opportune time for engaging with an intervention [<xref ref-type="bibr" rid="ref56">56</xref>]. On-demand is when users can choose when to engage with interventions freely from available microinterventions [<xref ref-type="bibr" rid="ref14">14</xref>]. These patterns are not mutually exclusive, as illustrated by Howe et al’s [<xref ref-type="bibr" rid="ref56">56</xref>] study, where on-demand features were available to both the JIT and prescheduled study conditions. It can be argued that Meinlschmidt et al [<xref ref-type="bibr" rid="ref48">48</xref>] leverage elements of both prescheduling, as engagement is expected daily, and on-demand, as users can choose their intervention and specific time during the day. Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>] let users choose when to request a microintervention while using JIT elements to recommend an intervention relevant to the user’s context.</p>
          <p>Many microintervention systems rely on users initiating when to engage [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. This may be based on their own sense of state and context [<xref ref-type="bibr" rid="ref76">76</xref>], or when possible, specified external factors [<xref ref-type="bibr" rid="ref62">62</xref>]. Most systems make use of hybrid approaches where both systems and end users are involved in decision-making [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. However, there are also examples of predominantly user-centered [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref63">63</xref>] and system-centered decision-making [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. As illustrated in <xref rid="figure3" ref-type="fig">Figure 3</xref>, this decision-making relationship can be seen as a continuum from predominantly user to system-controlled, with most systems falling into a hybrid category with various blends of the two, covering the levels of automation previously conceptualized [<xref ref-type="bibr" rid="ref77">77</xref>]. Importantly, this continuum may itself be subject to user preference; that is, users may have different preferences for the balance between automation and agency [<xref ref-type="bibr" rid="ref56">56</xref>].</p>
          <fig id="figure3" position="float">
            <label>Figure 3</label>
            <caption>
              <p>Decision-making continuum for microintervention systems.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e72658_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>The system or user decision-making process can, however, also be more complex, involving other users [<xref ref-type="bibr" rid="ref15">15</xref>], clinicians [<xref ref-type="bibr" rid="ref20">20</xref>], or be context-aware [<xref ref-type="bibr" rid="ref19">19</xref>]. Narratives can be provided by the system through decisions made by a clinician [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], digital apps [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], the end users [<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref76">76</xref>], and combinations of these actors [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>].</p>
          <p>In practice, users’ needs in such systems can be recognized in several ways, such as by users through subjective self-assessment [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], supported self-assessment, for example, visualization [<xref ref-type="bibr" rid="ref19">19</xref>], clinicians reviewing data [<xref ref-type="bibr" rid="ref20">20</xref>], or objective system assessment through recommendation techniques [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Machine learning has, for example, been used to trigger interventions in response to the user’s actions, as seen possible with the identification of compulsory hand washing [<xref ref-type="bibr" rid="ref73">73</xref>] and workplace stress [<xref ref-type="bibr" rid="ref56">56</xref>]. However, it may also be used to identify the most effective intervention for a specific user [<xref ref-type="bibr" rid="ref15">15</xref>]. Clinicians may likewise act in this role, recognizing a user’s state and context and suggesting relevant microinterventions [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref57">57</xref>].</p>
          <p>The D-MIST framework defines the microintervention system as delivering a narrative through its design and interaction model. We base the aims of the microintervention system on Baumel et al’s [<xref ref-type="bibr" rid="ref12">12</xref>] description of a hub: an entity that (1) recognizes an individual’s state and context, (2) recommends relevant interventions, and (3) helps create or maintain the narrative derived from each intervention as part of the larger therapeutic process. However, we also observe notable limitations with this description. First, it does not explicitly and adequately describe the roles of the system [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>] delivering the narrative experience. Second, its emphasis is on a single “entity” [<xref ref-type="bibr" rid="ref12">12</xref>] primarily fulfilling these aims rather than multiple actors collaboratively [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. JIT has, for instance, been leveraged to recommend when participants should engage in a microintervention in line with point (1); but with users determining which intervention to engage with in line with point (2) [<xref ref-type="bibr" rid="ref56">56</xref>], highlighting how multiple actors may collaboratively fulfill the aims outlined by Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>]. Third, interactions between actors (user, system, and others) as observed in the literature [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] are not explicitly modeled. As highlighted above, microintervention systems use different ways of interacting with microinterventions, levels of automation, user roles, and actors. Despite these differences, the overall aim of the system remains in line with Baumel et al’s [<xref ref-type="bibr" rid="ref12">12</xref>] definition. Given the many different ways these aims can be accomplished through the system, its actors, and interactions, we define the role of the microintervention system as:</p>
          <disp-quote>
            <p>The microintervention system, through its design and interaction model, aims to facilitate (1) the creation and maintenance of a narrative, (2) by serving relevant microinterventions, and (3) through recognition of the user’s situation, context, and needs.</p>
          </disp-quote>
          <p>We subsequently define the interaction model as:</p>
          <disp-quote>
            <p>The interaction model formalizes how the aims of the system are achieved through the users’ interactions with the system (eg, JIT and on-demand) and other actors (eg, health coaches and other users).</p>
          </disp-quote>
          <p>Not only do these definitions help outline the system’s role in delivering microintervention narratives, but they also formalize how narratives are formed through interactions between user, system, and other actors. A well-described interaction model also allows us to more easily compare the advantages and disadvantages of different approaches. We note that microintervention care has been defined by Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>] to refer to the abstract therapeutic process of using microinventions as building blocks; we have opted for a narrower definition here, centered around the facilitating microintervention system encompassing identified building blocks.</p>
          <p>In the example using Frank et al’s [<xref ref-type="bibr" rid="ref20">20</xref>] system, we note how users and clinicians collaboratively create a narrative, based on the clinicians’ understanding of user needs. Compared to interaction models where users themselves freely choose between microinterventions such as those by Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>] and Meinlschmidt et al [<xref ref-type="bibr" rid="ref63">63</xref>], the approach by Frank et al [<xref ref-type="bibr" rid="ref20">20</xref>], where clinicians provide microinterventions, may result in higher effectiveness but at the potential cost of user agency and self-exploration. Similarly, while JIT-based interaction models may recommend interventions at seemingly optimal moments, these may nevertheless appear contextually inappropriate for users [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref70">70</xref>].</p>
          <p>Having looked at the role of microintervention systems and how narratives emerge from interactions, it is worth returning for a moment to the rationale for <xref rid="figure2" ref-type="fig">Figure 2</xref>. The system, through its interactions, provides a consolidated narrative experience over time, in some cases initially consisting of one microintervention with more added over time. The system by Frank et al [<xref ref-type="bibr" rid="ref20">20</xref>], for instance, initially consists of an educational microintervention with additional microinterventions and events provided over time depending on collected data. Pascoe et al [<xref ref-type="bibr" rid="ref40">40</xref>] similarly present several microinterventions targeting, for example, stress, physical activity, and sleep in support of the overall narrative well-being goal, with one example being a mindfulness stress microintervention. However, each microintervention can also have more than one event [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Fuller-Tyszkiewicz et al’s [<xref ref-type="bibr" rid="ref14">14</xref>] mindfulness intervention, for example, consists of 9 events. However, we will describe the rationale for these components further in the following subsections.</p>
        </sec>
        <sec>
          <title>Narratives</title>
          <p>Narratives, where multiple microinterventions are used in combination, occur in more than half the literature (20/35, 57%), with 6 of these papers considering broader narrative implications. Narratives do not occur in 15 (43%) studies as these test microinterventions in isolation.</p>
          <p>Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>] create a narrative by having users request a microintervention for stress, with the system suggesting the most effective one based on user traits and the circumstances. Conroy et al [<xref ref-type="bibr" rid="ref18">18</xref>] randomized the time at which interventions arrive and selected a random message from three categories promoting physical activity. Clarke et al [<xref ref-type="bibr" rid="ref60">60</xref>] describe how the system chooses between 18 interventions initially at random and later based on how effective individual microinterventions were at alleviating stress, with the system aiming to provide personalized treatment, that is, an individually effective narrative. Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>] tested three ways of creating narratives through their study conditions: self-chosen interventions, randomized interventions, and recommended interventions, concluding that self-chosen and recommended narratives were equally effective at stress reduction. Meinlschmidt et al [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref63">63</xref>] had users themselves be responsible for determining the narrative by choosing between 4 microinterventions, whereas Everitt et al [<xref ref-type="bibr" rid="ref62">62</xref>] had users choose between interventions for improving mood, but also had the system provide JIT prompts for engagement.</p>
          <p>Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>] present a narrative of 11 ordered events which can be viewed as two microinterventions, mindfulness and gratitude, but note that participants were free to consume or repeat these and their events in any order they liked. Fuller-Tyszkiewicz et al [<xref ref-type="bibr" rid="ref14">14</xref>] also suggest that digital motivational content may increase motivation to engage in future microinterventions, implying there may be benefits from combining different interventions in terms of both attrition and overall effect [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. Two studies investigated this by considering the narrative implications of microinterventions, increasing the effectiveness of subsequent microinterventions, for example, by reducing stress-related barriers to concentration and learning [<xref ref-type="bibr" rid="ref57">57</xref>]. Other work suggests this extends to depression as well, which may present a significant barrier to engagement, for example, in diabetes [<xref ref-type="bibr" rid="ref78">78</xref>]. The other narrative consideration is the introduction of educational interventions, enhancing the enjoyment of, and motivation to engage in, subsequent microinterventions [<xref ref-type="bibr" rid="ref49">49</xref>]. Results suggest one microintervention successfully amplified the effects of another: that is, the effect of a loving-kindness meditation intervention was amplified by priming through a prior microintervention [<xref ref-type="bibr" rid="ref49">49</xref>].</p>
          <p>Despite most studies using a limited number of microinterventions and events, these still form “accounts of connected events,” that is, a narrative through the systems design and interaction model. Given that events aim to have an immediate effect on targeted attributes measured through proximal assessments [<xref ref-type="bibr" rid="ref12">12</xref>], it stands to reason that a microintervention’s effect is the synergized sum of event effects over time. Consequently, the effects of a narrative can be viewed as the synergized sum of its microinterventions with the events experienced by the end user. The narrative aim may be different from that of the individual microinterventions and their events, as seen, for example, in the work of Gummidela et al [<xref ref-type="bibr" rid="ref58">58</xref>], where shallow breathing (an event effect) is targeted as a proxy for stress (a microintervention effect). Sun et al show support for this, as improvement of microintervention goals, for example, physical activity and medication adherence, results in improvements to the narrative goals, that is, blood pressure [<xref ref-type="bibr" rid="ref72">72</xref>]. Consequently, we see three effect scopes and assessments that can be used: proximal assessment, looking at the individual event effects; microintervention outcome assessment, gauging the overall microintervention effect; and distal assessment, gauging the narrative effect. In type 2 diabetes, for example, the overall aim (distal effect) might be to reduce glycated hemoglobin [<xref ref-type="bibr" rid="ref79">79</xref>], with individual microinterventions aiming to improve self-management, through events aiming at reducing discounting of the future [<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. Thus, the narrative structure is responsible for creating a meaningful experience toward achieving the distal treatment goal of the system, trying to synergize the effects of different microinterventions. We thus define the narrative and the narrative thread as:</p>
          <disp-quote>
            <p>A narrative aims to address a clinical goal by creating a meaningful, connected story through its microinterventions and the events as experienced by the user.</p>
          </disp-quote>
          <disp-quote>
            <p>The narrative thread is the list of experienced microinterventions through their corresponding events, where each step is determined by the users’ circumstances and the best-fitting conceptual model.</p>
          </disp-quote>
          <p>This definition stands in contrast to Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>], which describes the narrative as the linking agent between interventions rather than referring to the consolidated experience. However, by emphasizing the narrative as the consolidated experience, D-MIST aims to promote explicit consideration for how microinterventions are used and combined over time to achieve distal outcomes. Narratives should aim to engage users through the deployment of meaningful, connected, and goal-relevant microinterventions.</p>
          <p>Low-intensity microinterventions could, for example, be used to promote initial engagement before transitioning to higher effort but more effective interventions [<xref ref-type="bibr" rid="ref56">56</xref>]. Other early microinterventions could reduce barriers to engagement, such as discounting of the future [<xref ref-type="bibr" rid="ref70">70</xref>] and stress [<xref ref-type="bibr" rid="ref57">57</xref>], and later microinterventions may attempt to address rising needs for novelty [<xref ref-type="bibr" rid="ref15">15</xref>]. Additionally, some users may not need certain microinterventions or may have a preference against some types of microinterventions [<xref ref-type="bibr" rid="ref70">70</xref>], making others more relevant in a narrative.</p>
          <p>The sparse narrative insights presented throughout the reviewed literature may hint that narrative considerations could be key to increasing perceived usefulness [<xref ref-type="bibr" rid="ref56">56</xref>], reducing attrition [<xref ref-type="bibr" rid="ref14">14</xref>], increasing or supporting the effectiveness of other microinterventions [<xref ref-type="bibr" rid="ref49">49</xref>], creating personally relevant experiences [<xref ref-type="bibr" rid="ref30">30</xref>], and addressing changing needs over time, for example, a need for novelty [<xref ref-type="bibr" rid="ref56">56</xref>]. The narrative thus presents significant opportunities for personalization in addressing needs and should aim to create a coherent experience over time in pursuit of the distal narrative goals.</p>
        </sec>
        <sec>
          <title>Microinterventions</title>
          <p>The majority of the microinterventions included in our review (<xref ref-type="table" rid="table1">Table 1</xref>) focus on either reducing stress (8/35, 23%), improving mood (8/35, 23%), or body dissatisfaction (7/35, 20%). The remaining studies (12/35, 34%) have various targets such as self-efficacy of parents [<xref ref-type="bibr" rid="ref38">38</xref>], reduction of unpleasant dreams [<xref ref-type="bibr" rid="ref74">74</xref>], compulsive hand washing [<xref ref-type="bibr" rid="ref73">73</xref>], promotion of physical activity [<xref ref-type="bibr" rid="ref18">18</xref>], hypertension [<xref ref-type="bibr" rid="ref72">72</xref>], or have multiple targets [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>].</p>
          <p>Digital interventions affecting stress include four overall therapy groups (or categories of microinterventions) [<xref ref-type="bibr" rid="ref15">15</xref>], namely: (1) Positive psychology, (2) Cognitive-behavioral, (3) Meta-cognitive, and (4) Somatic [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], that is, Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>] use these groups along with the nature of the intervention (individual or social) to classify their microinterventions consisting of a prompt and a link to the intervention resources. Another, more indirect approach to stress consists of targeting shallow breathing as a proxy for stress and anxiety [<xref ref-type="bibr" rid="ref58">58</xref>]. Other proposed categories for stress reduction include relaxation, response modulation, positive experiences, and resource buffers [<xref ref-type="bibr" rid="ref55">55</xref>].</p>
          <p>Two exceptions to the norm of digital interventions are music therapy [<xref ref-type="bibr" rid="ref57">57</xref>] and dance movement therapy [<xref ref-type="bibr" rid="ref71">71</xref>]. In music therapy, a clinician uses musical instruments with the patient to reduce stress by attunement through music [<xref ref-type="bibr" rid="ref57">57</xref>]. In dance movement therapy, a clinician suggests personalized physical exercises over the phone to, for example, alleviate stress. While these interventions are not facilitated through digital means, they are similar to the social interventions described by Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>], which rely on the inclusion of other actors.</p>
          <p>A common type of microintervention is the delivery of exercises such as mindfulness and relaxation [<xref ref-type="bibr" rid="ref62">62</xref>] or suggesting activities like various forms of meditation [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref68">68</xref>] and behavioral activation [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. We see this reflected in the studies looking at body satisfaction where meditation is used [<xref ref-type="bibr" rid="ref68">68</xref>], in addition to self-compassion [<xref ref-type="bibr" rid="ref69">69</xref>], themed social media posts [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], and exercises such as breathing, gratitude, and relaxation [<xref ref-type="bibr" rid="ref14">14</xref>]. The first and last of these are used to elicit mood change as well [<xref ref-type="bibr" rid="ref62">62</xref>]. Other implementations include the reduction of social anxiety through reappraisal [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref76">76</xref>] and increasing physical activity through educational, motivational, and actionable messages [<xref ref-type="bibr" rid="ref18">18</xref>]. Microinterventions also leverage more passive approaches, such as a visual digest of mood [<xref ref-type="bibr" rid="ref19">19</xref>], allowing users to react when they feel it necessary.</p>
          <p>One issue created by the definitions of a microintervention so far is the ambiguity of what can be considered a single microintervention and an event. We observe, in line with Fuller-Tyszkiewicz et al’s [<xref ref-type="bibr" rid="ref14">14</xref>] description of microinterventions, that the events may be single-use, designed for repetition, or offer content variations to maintain user interest. However, a microintervention may also consist of other event types: for example, sequential events. We base this on the results of our review, specifically that some microinterventions may have prerequisites [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] or be sequential [<xref ref-type="bibr" rid="ref14">14</xref>] with, for example, Vandesande et al [<xref ref-type="bibr" rid="ref38">38</xref>] using sequential videos to deliver psychoeducation. While it could be argued that each video in this example in itself is “one” single-event microintervention with an effect, knowledge from one video may be necessary to understand another video’s content. Thus, subsequent events are not isolated and cannot be considered a series of single-use microinterventions that are part of a narrative, but should rather be considered as one microintervention consisting of several events to be consumed in order. A number of works nevertheless use single-event microinterventions [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref66">66</xref>], for instance, a minicourse positively impacting body image [<xref ref-type="bibr" rid="ref66">66</xref>]. These may be reminiscent of prior works on “single-session interventions” [<xref ref-type="bibr" rid="ref82">82</xref>]. Consequently, we define a microintervention as:</p>
          <disp-quote>
            <p>A microintervention is a highly focused type of therapy relying on one or more events of a given type, each attempting some momentary change.</p>
          </disp-quote>
          <p>As with previous definitions of microinterventions, this still creates some ambiguity as to what can and cannot be considered a single microintervention; however, we believe this ambiguity is a question of design, that is, several different microinterventions may target the same symptom or attributes but be designed in such a way that they rely on different numbers of events and types of resources. Similarly, each design may be subject to different conceptual models for when to make narrative use of each microintervention based on user needs, preferences, and other factors.</p>
          <p>Returning to the previous example on sleeping habits, a focused microintervention may attempt to reduce unpleasant dreams [<xref ref-type="bibr" rid="ref74">74</xref>] through repeated daily reflection events; another may aim to motivate users to wake up at the same time every day by suggesting a variety of behaviors such as going for a walk or meeting friends for coffee [<xref ref-type="bibr" rid="ref20">20</xref>]. A microintervention could also aim to reduce factors affecting sleep, such as late-night screen time [<xref ref-type="bibr" rid="ref20">20</xref>], through single-use events or a sequence of educational events.</p>
        </sec>
        <sec>
          <title>Events</title>
          <p>The number of events and how these are used in individual works differ significantly; an overview of event components can be seen in <xref rid="figure4" ref-type="fig">Figure 4</xref>.</p>
          <p>Conroy et al [<xref ref-type="bibr" rid="ref18">18</xref>], for instance, include 456 unique events, while the work by Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>] contains 160. While all these types of events can be classified as “single” events, they could also be seen as “variations” to maintain engagement over time [<xref ref-type="bibr" rid="ref14">14</xref>]. A number of studies further test single-event microinterventions, including Kim et al’s [<xref ref-type="bibr" rid="ref16">16</xref>] behavioral activation exercise affecting mood and Gobin et al’s [<xref ref-type="bibr" rid="ref69">69</xref>] self-compassion exercise affecting body dissatisfaction. While these two examples only used each event once, these could be used repeatedly, as seen in other works [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. The exercises presented by Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>], meanwhile, present variation in that the resource content provided can differ between uses.</p>
          <p>Events may also form logical sequences [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. Vandesande et al [<xref ref-type="bibr" rid="ref38">38</xref>], for example, include the use of psychoeducation to build up self-efficacy knowledge through several videos. Van Cappellen et al [<xref ref-type="bibr" rid="ref49">49</xref>] use one event to increase the enjoyment and continued practice of meditation events, that is, a form of priming, while Persson et al [<xref ref-type="bibr" rid="ref39">39</xref>] use one event as a prerequisite for others.</p>
          <p>Events can also be adaptive [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], serving resources that match users’ momentary abilities; a microintervention serving short physical activity exercises may, for example, attempt to adapt the resource to match users’ exercise level [<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]. Events may adapt the resource itself to the context or its dose [<xref ref-type="bibr" rid="ref11">11</xref>] or provide “variations” to maintain interest and engagement [<xref ref-type="bibr" rid="ref14">14</xref>]. Another somewhat extreme example of an adaptive event is prompting users to “Take a moment and do whatever comes to mind to reduce your stress” (Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>]).</p>
          <fig id="figure4" position="float">
            <label>Figure 4</label>
            <caption>
              <p>Summary breakdown of events as seen throughout the included literature.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e72658_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>The length of the events presented also varies. The messages used by Conroy et al [<xref ref-type="bibr" rid="ref18">18</xref>] can be consumed within a matter of seconds, while Johnson et al [<xref ref-type="bibr" rid="ref55">55</xref>] tested both short 2-minute and one 20-minute microintervention. Despite educational events being between 10 and 19 minutes [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], most events last a few minutes [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref74">74</xref>], indicating that a few minutes is perceived to match users’ capacity for engagement [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. Authors such as Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>] and Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>] also emphasize that events should last less than 3 minutes, while Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>] simply emphasize that the duration should match users’ capacity more broadly. As explored in previous examples, resources delivered by events provide a multitude of content (eg, psychoeducation and exercises) through various formats (eg, text and video), an overview of which can be seen in <xref rid="figure4" ref-type="fig">Figure 4</xref> and <xref ref-type="table" rid="table2">Table 2</xref>.</p>
          <p>Baumel et al [<xref ref-type="bibr" rid="ref12">12</xref>] have previously described events as the smallest element of the microintervention, which attempts some in-the-moment change or impact toward intervention targets. This is accomplished through the event’s resource [<xref ref-type="bibr" rid="ref14">14</xref>] and served according to its type. Events can be classified based on therapeutic group or on whether they can be consumed alone or with others [<xref ref-type="bibr" rid="ref15">15</xref>]. Furthermore, some events may have prerequisites, interdependencies, or logical order to them and may be adaptive in nature.</p>
          <p>Based on the literature, we have identified five overall types of events: single-use events— where a single resource is used exactly once. Repetition events—where a single resource is used repeatedly. Variation events—where variations of a resource are used repeatedly. Sequential events—where resources are order-dependent or in a logical sequence. Adaptive events—where the resource itself or the intensity varies or is tailored to users. Based on these insights, we defined an event as:</p>
          <disp-quote>
            <p>An event provides resources as required by its intended types and therapeutic groups, with an immediate positive effect on target attributes.</p>
          </disp-quote>
          <p>We define event types as:</p>
          <disp-quote>
            <p>The event type refers to the way the event is used. Events can be classified as single-use, repeated, varied, sequential, or adaptive.</p>
          </disp-quote>
          <p>We use the term “attribute” rather than “symptom” as events may target not only symptoms but also more abstract targets such as enjoyment or motivation to engage in subsequent interventions. Resources may further be defined as:</p>
          <disp-quote>
            <p>Each resource provides a piece of content (eg, a video, exercise, or call to action) in various formats, aiming to facilitate an immediate positive effect on target attributes.</p>
          </disp-quote>
          <p>The event presented by Malouff and Johnson [<xref ref-type="bibr" rid="ref74">74</xref>], for example, used a text-based resource containing instructions for a small exercise done before bed, aiming to reduce unpleasant dreams, which can be used once (or potentially repeatedly). A microintervention aiming to reduce nightly screen time could use resources such as educational videos or JIT text-based warning or reminder notifications to achieve immediate effects [<xref ref-type="bibr" rid="ref20">20</xref>].</p>
        </sec>
        <sec>
          <title>Decision Rules, Conceptual Models, and Assessments</title>
          <p>In this section, we cover insights on when individual events are deployed through decision rules, when microinterventions are relevant in a narrative through conceptual models, and which assessments are used.</p>
          <p>Decision rules are often triggered by combinatory [<xref ref-type="bibr" rid="ref85">85</xref>] data collection [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]: system-driven [<xref ref-type="bibr" rid="ref60">60</xref>], user-driven [<xref ref-type="bibr" rid="ref62">62</xref>]. Collection occurs both by subjective assessments using questionnaires and objective system-driven data collection, for example, biometrics [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. In mood interventions, we see both collection types used through assessments and the collection of GPS, conversational feature identification, and sleep monitoring [<xref ref-type="bibr" rid="ref19">19</xref>]. Examples of user-driven data collections include the recording of meals, ecological momentary assessments such as mood check [<xref ref-type="bibr" rid="ref62">62</xref>], and standardized assessments such as the Multidimensional Mood State Questionnaire [<xref ref-type="bibr" rid="ref63">63</xref>].</p>
          <p>Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>] use six decision rules for event deployment, including a computed stress score (based on email volume, calendar saturation, time, facial expression, heart rate, and assessments) and 5 timing-related rules, for example, within working hours and no intervention completed in the past hour. Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>], meanwhile, use machine learning to suggest the most effective events based on users’ stress score, the number of tabs open, and user settings. Stress detection can also make use of specialized technology such as webcam-based heart rate monitoring [<xref ref-type="bibr" rid="ref56">56</xref>], smartwatches [<xref ref-type="bibr" rid="ref60">60</xref>], and a harness chest strap for measuring breathing rate [<xref ref-type="bibr" rid="ref58">58</xref>]. The “mStress” app, for example, uses three modules: a stress recognition module, a set of stress interventions, and an intervention recommender module based on a Q-Learning algorithm [<xref ref-type="bibr" rid="ref60">60</xref>]. Other system-driven data collection methods used are activity monitors [<xref ref-type="bibr" rid="ref18">18</xref>] and smartwatches [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]. A summary breakdown of factors considered in decision rules can be seen in <xref rid="figure5" ref-type="fig">Figure 5</xref>.</p>
          <fig id="figure5" position="float">
            <label>Figure 5</label>
            <caption>
              <p>Summary breakdown of microintervention decision rules as seen throughout the included literature.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e72658_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>Many decision rules are also presented more implicitly; for example, several studies allow users to choose between interventions or events based on a prior introduction to these [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>], for instance, introduce users to interventions through a home screen showing a title, image, and short textual descriptions of the intervention.</p>
          <p>While no studies explicitly address conceptual models for various microinterventions, some can be derived from reported results (<xref rid="figure6" ref-type="fig">Figure 6</xref>). We note that many of these share the attributes seen in decision rules. All presented interventions have well-described targets such as stress, mood, or body dissatisfaction, or physical activity motivation [<xref ref-type="bibr" rid="ref18">18</xref>] or parent self-efficacy [<xref ref-type="bibr" rid="ref38">38</xref>]. Other details on applicability, such as those exemplified in <xref rid="figure6" ref-type="fig">Figure 6</xref>, including demographic targets or user traits, are sparser.</p>
          <p>Some microinterventions have multiple purposes; for example, mindfulness has been used to improve both mood [<xref ref-type="bibr" rid="ref62">62</xref>] and body satisfaction [<xref ref-type="bibr" rid="ref68">68</xref>], and other meditation exercises have been used to affect sleep, anxiety, and stress [<xref ref-type="bibr" rid="ref86">86</xref>-<xref ref-type="bibr" rid="ref88">88</xref>]. Thus, interventions may have multiple targets reflected by different conceptual models.</p>
          <p>However, the conceptual models may also be more implicit: Pascoe et al [<xref ref-type="bibr" rid="ref40">40</xref>], for example, allow users to tailor their own well-being narrative by providing a choice to join a daily session, comprising six microinterventions affecting, for example, stress management, physical activity, or improving sleep, with event content varying between days.</p>
          <p>A number of assessment methods have been used to inform both decision rules and conceptual models, such as Patient Health Questionnaire-8 or -9 [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref62">62</xref>] and state body image [<xref ref-type="bibr" rid="ref69">69</xref>]. Nemesure et al [<xref ref-type="bibr" rid="ref66">66</xref>] used two 5-point scales to determine perceived body image and motivation to improve body image, and Kim et al [<xref ref-type="bibr" rid="ref16">16</xref>] used a 9-point Likert scale to measure mood and confidence in mood self-improvement.</p>
          <fig id="figure6" position="float">
            <label>Figure 6</label>
            <caption>
              <p>Examples of possible components of conceptual models used to determine intervention relevance to the narrative.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e72658_fig6.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>Generally, we see significant similarities between decision rules and conceptual models. User traits and preferences may both inform whether an intervention should be used, but may likewise affect the timing of interventions, for example, situational appropriateness. Decision rules (often called triggers within the field of software engineering) aim to detail when and where events should be deployed [<xref ref-type="bibr" rid="ref12">12</xref>]. While relatively few papers explicitly report decision rules, insights can be drawn from both proximal and distal assessments used by these studies. Many assessment methods are therefore interesting not only for their ability to determine in-moment effects and distal outcomes but also to inform conceptual models determining whether a particular type of microintervention could be used in a certain context [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
          <p>Thus, conceptual models determine which of the available microinterventions are being served, with specific timing controlled by the decision rules. Moreover, given that microinterventions can be JITAI in nature [<xref ref-type="bibr" rid="ref14">14</xref>], we add, in line with Nahum-Shani et al’s [<xref ref-type="bibr" rid="ref23">23</xref>] definition of JITAI decision rules, that these can also affect the intensity. We thus define decision rules as:</p>
          <disp-quote>
            <p>Decision rules determine which events should be triggered, the intensity of the event, and the conditions under which they should be triggered (eg, contextual factors, time of day, or user’s state).</p>
          </disp-quote>
          <p>We define conceptual models as:</p>
          <disp-quote>
            <p>Conceptual models describe the conditions for when and where a microintervention is relevant and can be used as part of a narrative.</p>
          </disp-quote>
          <p>For example, a prerequisite for the deployment of sleep habit microinterventions in a mood narrative is the need for such interventions reflected by a conceptual model, identified through detection of nightly screen time or poor sleep rhythms. However, if users do not have a need for such microinterventions, it is not meaningful to deploy them. Instead, users are better served by other microinterventions.</p>
          <p>In the case of events aiming to reduce unpleasant dreams, the only decision rule for deployment relates to whether users are about to head to bed, while JIT screen time events could consider screen activity, time of day, time since last event, and which events are best to deploy, for example, educational, motivational, or calls to action.</p>
        </sec>
        <sec>
          <title>User Experience and Personalization</title>
          <p>Given that much of the potential of microintervention technologies lies in their flexibility and personalization potential, we want to highlight some of the user experience insights found in the literature. User experience and usability were explicitly assessed and reported in some studies (15/35, 43%), with usability, acceptance, and interest rated highly when reported [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. The study by Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>] finds that on-demand may have advantages over prescheduled interventions as participants choose to use the on-demand feature when stressed, causing greater reductions. Participants themselves seemed to prefer JIT, despite some indications that prescheduled may be more effective for behavior change. Similarly, another study found that JIT did not have tangible benefits over the non-JIT condition, noting this could be due to contextual inconveniences of interventions [<xref ref-type="bibr" rid="ref62">62</xref>]. Another study noting similar inconveniences noted this could be due to a lack of user involvement in development, as also reflected in users finding the overall program unhelpful [<xref ref-type="bibr" rid="ref40">40</xref>]. However, another study reported that users found microinterventions helpful when experiencing an effect [<xref ref-type="bibr" rid="ref54">54</xref>], and that reminders could act as behavioral nudges [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref70">70</xref>], but noted negativity toward repetition [<xref ref-type="bibr" rid="ref54">54</xref>].</p>
          <p>User preferences for engagement, timing, and context are reported as versatile and wide-ranging between people and even within the same individual over time, with the need for multiple levels of user control [<xref ref-type="bibr" rid="ref56">56</xref>]. Contextual tailoring of content has also been noted to promote engagement and increased effectiveness compared to other conditions [<xref ref-type="bibr" rid="ref15">15</xref>], highlighting a need for systems delivering contextually relevant and user-preferred content [<xref ref-type="bibr" rid="ref54">54</xref>]. When given a choice, users seem to prefer certain interventions even if these are not the most effective [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Paradoxically, one study found that users perceive low-effort interventions as more helpful despite results indicating higher effectiveness from high-effort ones [<xref ref-type="bibr" rid="ref56">56</xref>]. Perceived usefulness likewise seems to play an important role in attrition, as those who initially experienced larger immediate improvements were less likely to drop out [<xref ref-type="bibr" rid="ref14">14</xref>]. Other aspects of personalization include individual versus social microinterventions to better suit user preference [<xref ref-type="bibr" rid="ref15">15</xref>] and the need for novelty itself [<xref ref-type="bibr" rid="ref56">56</xref>]. One study further reported that some users prefer a higher or lower number of sessions, longer or shorter training, indicating these as parameters for personalization that may increase acceptance [<xref ref-type="bibr" rid="ref48">48</xref>].</p>
          <p>Generally, the levels of personalization available to users across studies vary greatly; there is no one-size-fits-all intervention [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref89">89</xref>] as different users may have different preferences or needs for the level of personalization available and the extent to which they can control the system. Based on these insights and the D-MIST framework, we propose four levels for personalization that can be found in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. These may occur through the user’s control or automated system adaptation at each level: event, microintervention, narrative, or system adaptation.</p>
        </sec>
        <sec>
          <title>Efficacy</title>
          <p>In this section, we will briefly cover the effects reported by the included literature.</p>
          <p>Interventions addressing body dissatisfaction have found both event and microintervention effects, although these report mixed results as to whether effects persist past the intervention or not [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Self-compassion tasks and meditation interventions, for example, both elicited positive results in body dissatisfaction [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. However, no poststudy retention of these effects was found after 7 days despite consistent immediate effects [<xref ref-type="bibr" rid="ref65">65</xref>]. Conversely, Fardouly et al [<xref ref-type="bibr" rid="ref67">67</xref>] reported that viewing a small number of positive and neutral body social media posts not only had immediate effects but also that these were retained after 4 weeks.</p>
          <p>In stress interventions, there are indications of positive effects after 4 weeks, for example, higher stress self-awareness and a reduction of depressive symptoms, with interventions chosen by machine learning showing better coping behaviors [<xref ref-type="bibr" rid="ref15">15</xref>]. Momentary stress reduction effects seem persistent between delivery methods, such as prescheduled versus JIT. However, prescheduling was associated with greater advancement through behavior change [<xref ref-type="bibr" rid="ref56">56</xref>]. Additionally, a gamified approach may be advantageous compared to other conditions in terms of effects and enjoyment [<xref ref-type="bibr" rid="ref58">58</xref>]. Tong et al [<xref ref-type="bibr" rid="ref54">54</xref>] found system-chosen and user-chosen microinterventions to have similar effectiveness, but note that the system-chosen provides greater variety in used intervention content. Johnson et al [<xref ref-type="bibr" rid="ref55">55</xref>] reported a higher effect from a single 20-minute video-based microintervention compared to 16 2-minute microinterventions, although 2-minute microinterventions may be more applicable in certain contexts. Johnson et al [<xref ref-type="bibr" rid="ref55">55</xref>] further speculate that multiple microinterventions tailored to the individual and their specific context may have additive effects related to both proximal and distal outcomes.</p>
          <p>Momentary effects are likewise reported for mood [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], with indications that there are declines in depressive and anxiety symptoms over time, with one study noting no added benefits from JIT [<xref ref-type="bibr" rid="ref62">62</xref>]. Momentary effects also include the microintervention’s ability to reduce the frequency of unpleasant dreams [<xref ref-type="bibr" rid="ref74">74</xref>] and reduce social anxiety [<xref ref-type="bibr" rid="ref76">76</xref>]. Other distal effects reported include the ability to increase physical activity [<xref ref-type="bibr" rid="ref18">18</xref>], improve self-efficacy of parents of children with severe disabilities [<xref ref-type="bibr" rid="ref38">38</xref>], improve meditation adherence [<xref ref-type="bibr" rid="ref49">49</xref>], and improve systolic blood pressure [<xref ref-type="bibr" rid="ref72">72</xref>].</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Results</title>
        <p>The D-MIST framework provides a useful tool for designers and researchers to design and study narratives and their effects, including opportunities for personalization of the constituent components. It can be particularly helpful when comparing different systems, when considering reuse of components from other systems, when detailing and linking components to their outcomes, and as a way to structure and describe new designs.</p>
        <p>Compared to prior works defining microinterventions [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>], D-MIST is the first to look at microinterventions from a system perspective and the first to define and detail how these systems operate through various interactions. D-MIST’s interaction model is additionally the first to explain how different modes of interaction with the system and the inclusion of other actors form a consolidated narrative over time. The D-MIST framework is a domain-situated framework that leaves the choice of which BCT to deploy for momentary change as a design choice, as opposed to more general DBCIs. Unlike previous intervention patterns [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref46">46</xref>], microinterventions operate exclusively with short events, aiming to have an immediate impact [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. While these typically operate as EMI [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref70">70</xref>], there are some exceptions where these do not occur naturally in users’ daily lives [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. We have also seen that microinterventions are not necessarily JIT or JITAI. The D-MIST framework, therefore, covers both microinterventions that use these patterns, for example, JIT [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], and those that do not, for example, on-demand [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>].</p>
        <p>The D-MIST framework allows for creating and systematically describing an overall integrative and coherent experience at all levels encountered by the user, including the narrative, microinterventions, and their connected events. The D-MIST framework collects scattered insights highlighting the role of the narrative in addressing diverse needs and preferences over time. This led to insights into actors’ roles in the creation and maintenance of narratives over time. One advantage of the clear narrative, microintervention, and event separation is that it allows for independent testing and evaluation, for example, of microinterventions [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref90">90</xref>] or events [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Individual narrative components can thus be evaluated ahead of time, providing options for improvement or selection. Tests may help explore the relevance of the microintervention to designated users and circumstances, informing conceptual models and decision rules.</p>
      </sec>
      <sec>
        <title>Overall Design Guidelines</title>
        <sec>
          <title>Design Approaches</title>
          <p>Two ways to design microintervention systems are top-down and bottom-up. In a top-down approach, designers may start by (1) considering the facilitating systems’ role, including its intended interaction model, followed by (2) considering the narrative aims and intended user experience over time, and (3) including which microinterventions and events are relevant to the desired narrative or designing new microinterventions based on the narrative needs.</p>
          <p>We may, for example, aim to create a system that helps users sleep better (narrative goal) with an on-demand user-controlled interaction model. Initially, this could be supported by educational microinterventions and later, based on user self-identified needs, for example, reducing unpleasant dreams or reducing nightly screen time.</p>
          <p>In a bottom-up approach, designers may start by (1) selecting, gathering, or designing a catalog of microinterventions and their events, then (2) exploring and designing various narrative experiences based on the included catalog, and finally, (3) designing how these narrative experiences may be facilitated by the system and interaction models.</p>
          <p>When designing a sleep-improving system, designers may have a good grasp on factors affecting sleep and microinterventions that help mitigate these. Designers may desire to create a narrative experience where users are served these microinterventions based on their needs, so as not to overwhelm users with less relevant microinterventions. This could result in an interaction model where the system collects data, analyzed by clinicians who then recommend microinterventions based on identified needs.</p>
          <p>These approaches and examples are, however, rather simplified and do not consider more iterative or user-centered approaches to design, which we highly advocate for. Given that microinterventions aim to be flexible, match user preferences, capacity for engagement, and need, there seems to be significant advantages in using more user-centered approaches to design, for example, co-design or cocreation [<xref ref-type="bibr" rid="ref44">44</xref>], allowing cooperative design and exploration of systems and microinterventions when useful. <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref> highlights a more detailed example of a top-down approach.</p>
          <p>In a recent co-design project, end users designed a web-based microintervention system focused on short videos providing education and presenting different approaches to self-management behaviors. Users themselves specified (in a top-down fashion) the overall system requirements, interaction model, overall narrative expectations, and even designed groups of content (events) bound together by need or topic (microintervention). Groups of educational videos were imagined providing various means of increasing physical activity, followed by groupings of the videos presenting more details on these approaches, including implementation and tips, and a discussion on their relevance (ie, the conceptual models and the narrative over time). Interestingly, neither D-MIST nor microintervention terminology was brought up by facilitating authors practicing proactive neutrality [<xref ref-type="bibr" rid="ref91">91</xref>], nor was it explicitly used by participants in the process; however, it resulted in a system that fits the D-MIST framework.</p>
        </sec>
        <sec>
          <title>System Design</title>
          <p>The type of microintervention system heavily influences the design and implementation. JIT systems may be more challenging to develop due to the need for more explicit [<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref92">92</xref>-<xref ref-type="bibr" rid="ref94">94</xref>] operational conceptual models and decision rules for when to trigger specific microinterventions and events. On-demand and prescheduled systems, on the other hand, may not need to deal explicitly with conceptual models or decision rules as users themselves choose when and which microinterventions and events to engage with. Such designs, however, may consequently push larger responsibilities to the user [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], even if increasing the user’s agency. Alternatively, combining different actors in the interaction model may be considered [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. Future work should explore the advantages and disadvantages of existing [<xref ref-type="bibr" rid="ref56">56</xref>] and new interaction models.</p>
        </sec>
        <sec>
          <title>Narratives</title>
          <p>The D-MIST framework highlights the importance of the narrative structure not only in telling a meaningful story but also in ensuring that the order in which interventions are presented is meaningful to the goal, the user’s situation, and needs over time. <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] presents an example of a microintervention narrative aiming to improve physical activity through various microintervention goals, with <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref> presenting an example of how a monitoring-analysis-intervention approach may be used in the context of microinterventions. Designers need to consider how the narrative is presented, even if users themselves are ultimately responsible for consuming the presented events, and thus become the owners of the narrative. However, the ownership in, for example, a clinical context, could also be shared between the actors (patient and provider) [<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref96">96</xref>]. Interactions could also be more complex, for example, targeting both couples [<xref ref-type="bibr" rid="ref97">97</xref>,<xref ref-type="bibr" rid="ref98">98</xref>] or adults and their dependents [<xref ref-type="bibr" rid="ref99">99</xref>-<xref ref-type="bibr" rid="ref101">101</xref>], where one actor may act as a medium for another. Further, it has previously been argued that users are often unable to recognize the need to engage and what support is needed [<xref ref-type="bibr" rid="ref23">23</xref>]. This suggests that there may be advantages of increasing the systems’ ownership of the narrative [<xref ref-type="bibr" rid="ref56">56</xref>], although recent studies contest this notion [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>].</p>
          <p>When building on-demand and prescheduling [<xref ref-type="bibr" rid="ref56">56</xref>] features, designers should pay close attention to how users are expected to create the narrative, for example, by presenting microinterventions and events in the order they are to be consumed [<xref ref-type="bibr" rid="ref22">22</xref>]. We suggest providing users with transparent information on the relevance of interventions in a given context. This may, however, pose challenges for systems with large catalogs of interventions that may need to be prioritized, grouped [<xref ref-type="bibr" rid="ref22">22</xref>], or have the system recommend a subset of relevant interventions [<xref ref-type="bibr" rid="ref15">15</xref>] for the user to choose between.</p>
        </sec>
        <sec>
          <title>Building Microinterventions and Events</title>
          <p>When building microinterventions, it is important for designers to consider the scope of the intervention, including the number, types, and context of events. A rule of thumb is that microinterventions and their events should be designed with the user segment in mind and aim to match their capacity for engagement [<xref ref-type="bibr" rid="ref12">12</xref>]. Moreover, events could contain variations of exercises to engage users for longer periods [<xref ref-type="bibr" rid="ref14">14</xref>]. Designers might also consider whether events should have a logical order to them [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>] and whether these should have adaptive elements, for example, adjusting exercise length or resource format to match context [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. Contemporary studies suggest that a need for novelty in interventions occurs rapidly [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], implying that most microinterventions should not be used indefinitely.</p>
          <p>When creating events, designers should first consider the aim of the microintervention, the number of connected events, and their type. This informs the initial considerations on decision rules, including their contextual appropriateness and internal dependencies [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Designers should also carefully choose which resources best engage users’ expected contexts; for example, certain exercises may be best facilitated using audio [<xref ref-type="bibr" rid="ref62">62</xref>], others, imagery and text [<xref ref-type="bibr" rid="ref39">39</xref>].</p>
          <p>Events may be designed in a number of ways; for example, Paredes et al [<xref ref-type="bibr" rid="ref15">15</xref>] demonstrate how events may be developed from “Pop-Culture” [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Others adapt existing interventions like behavioral activation [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref17">17</xref>] and episodic future thinking [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref102">102</xref>], or are inspired by related studies [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. The significant literature on BCTs and established interventions may also be of particular interest in developing new microinterventions and events.</p>
          <p>Designers and researchers may find small trials [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref74">74</xref>] useful in determining effects and user perceptions of events, guiding the design of their decision rules. Prior works have used the Amazon Mechanical Turk for this purpose [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref55">55</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Users’ Role and Narrative Scopes</title>
        <p>While the currently presented systems operate primarily in the range between a day and a month, we see significant potential in systems that can deploy microinterventions for prolonged periods of time. Behavior change is well known for being challenging, often taking considerable time. Microintervention systems, by their nature, have the potential to support users with microinterventions, engaging them only when necessary and potentially reducing user fatigue and attrition, short-term, as well as long-term. For instance, a system aiming to support stress reduction through narratives may operate at a short or intermediate timeframe, while support for chronic illness may need to consider longer-term, distal perspectives. Such perspectives could, for example, take the form of a system acting as a companion, digital nurse, or facilitate microintervention delivery based on a nurse or clinician’s assessment [<xref ref-type="bibr" rid="ref20">20</xref>]. Overall, how long a microintervention system should aim to operate is tied to the use case and overall design, including the system’s interaction model.</p>
        <p>As we have highlighted through this paper, the interaction model can be used to describe or explain the relationship between the user, the system, and other actors. This model is particularly important as it explains a crucial part of the system, namely, how interventions are delivered to the user. We have previously noted how, for example, a narrative may be facilitated between user and clinician through the system or may be user or system-controlled. Hence, the interaction model can make such relationships more explicit. Of course, as denoted by our definition of a microintervention system, the narrative should be viewed in light of both the system design and interaction model. While the interaction model formalizes how the aims of the system are met, the design also plays a key role. The system design may, for instance, be an ordered list of microinterventions, unlocked by order of consumption, or may have the users periodically choose which microinterventions they engage with, in which case users directly engage with the narrative. Alternatively, in a JIT type system, the narrative can be hidden behind the scenes or shown to users through a history of interventions. In this way, the narrative can be seen both as a tool for design and, in other cases, as something users interact with directly.</p>
        <p>While one of the inherent aims of microinterventions is to reduce fatigue by lowering barriers to engagement by their short nature [<xref ref-type="bibr" rid="ref12">12</xref>], there are indications that a need for novelty can appear relatively quickly and that repetition can be seen negatively [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. This may indicate that the nature of a single microintervention by itself is not enough to fully mitigate fatigue. D-MIST aims to address this by emphasizing the expectation that microinterventions are deployed with a finite lifespan and can be switched or interchanged in accordance with users’ evolving circumstances, that is, here, the need for novelty. However, user needs may also change more fundamentally over time, for instance, due to the progressive nature of type 2 diabetes, which may necessitate the deployment of more microinterventions and events over time, responding to emerging needs such as diabetes distress [<xref ref-type="bibr" rid="ref78">78</xref>]. D-MIST’s emphasis on deploying microinterventions based on users’ circumstances and best-fitting conceptual models (ie, the available microinterventions) aims to keep the narrative coherent and thus prompt designers to more explicitly consider evolving needs over time. In the case of more user-controlled narratives, it may include features for supporting users to self-identify needs, while in other settings, it may be done through interactions with clinicians or even automatically by the system.</p>
      </sec>
      <sec>
        <title>Narratives for Personalization and Improved Distal Outcomes</title>
        <p>While we have seen a few considerations for narratives leveraging the synergy between microinterventions, early results are promising. Various authors [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>] note that there seem to be advantages to combining different types of interventions. Howe et al’s [<xref ref-type="bibr" rid="ref56">56</xref>] finding that users are inclined to see low-effort interventions as more useful and Fuller-Tyszkiewicz et al’s [<xref ref-type="bibr" rid="ref14">14</xref>] finding that perceived usefulness has an impact on dropout rates indicate that there are advantages in using low-effort interventions initially compared to more clinically relevant but intensive interventions. This further supports the notion that users may not wish to invest much effort in interventions [<xref ref-type="bibr" rid="ref12">12</xref>]. Similarly, laboratory results suggest that a priming or educational microintervention can increase subsequent engagement [<xref ref-type="bibr" rid="ref49">49</xref>]. Some authors likewise suggest targeting barriers stemming from stress or depression to increase subsequent engagement [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. Leveraging such effects seems key to achieving distal effects while increasing engagement, reducing attrition, and ultimately improving long-term health outcomes.</p>
        <p>However, the idea of creating personalized narratives is contingent on our understanding of the users and the building blocks we use. Most studies report positive effects [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref74">74</xref>], although varying between in-moment and more persistent effects [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Multiple different microinterventions can also affect the same targets, but insights into the user experience suggest users may have different personal preferences for these [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], affecting the perceived usefulness and uptake.</p>
        <p>Digital solutions also offer benefits beyond clinician-provided care, such as constant availability [<xref ref-type="bibr" rid="ref103">103</xref>] and discrete daily use. The availability of mobile health has caused a shift away from strictly clinical settings toward self-exploration using technology [<xref ref-type="bibr" rid="ref13">13</xref>]. Traditionally, interventions and health care have been provided by professionals based on an understanding of the patient’s health needs, suggesting relevant interventions at their discretion. Nevertheless, research suggests patients’ experiences are not always in line with clinical judgment [<xref ref-type="bibr" rid="ref104">104</xref>] and that limiting patients’ autonomy may hinder the exploration of self-management, impacting long-term engagement [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref78">78</xref>].</p>
        <p>However, high attrition is common in digital health [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>], with some noting a lack of rigorous study practice, clear evidence-based therapeutics, and clinical evidence [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref105">105</xref>,<xref ref-type="bibr" rid="ref106">106</xref>]. Moreover, as shown by Howe et al [<xref ref-type="bibr" rid="ref56">56</xref>], users may not always be aware of which microinterventions are the most effective in reducing symptoms. This is also supported by Van Cappellen et al [<xref ref-type="bibr" rid="ref49">49</xref>], speculating that users’ increased engagement was caused by a psychoeducational microintervention, allowing participants to engage with meditation more effectively. More broadly, the relationship between health knowledge, preferences, and effectiveness in microinterventions has yet to be explored, presenting opportunities for future research.</p>
        <p>Despite D-MIST being built on a review of more than 30 microintervention systems covering more than 500 unique events, we know little about each microintervention’s best use, its conceptual models, and narrative implications, with Hojjatinia et al [<xref ref-type="bibr" rid="ref30">30</xref>] noting the need for person-specific rules. The insights we uncovered on narrative tailoring suggest it may be key to designing systems that enhance activity enjoyment, motivation, retention, and ultimately improve distal outcomes [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. This highlights the need for more research on narratives and conceptual models, including user-centered factors.</p>
      </sec>
      <sec>
        <title>Limitations and Future Works</title>
        <p>As a consequence of the early stage of research in microinterventions and our desire to create a framework rather than systematically describe the entire body of literature, we have chosen a CIS approach. The CIS method [<xref ref-type="bibr" rid="ref24">24</xref>] allowed us to use the available evidence effectively, even if the field of research is not fully formed. While we developed and validated the framework through the CIS methodology, through the experience of the research team, and through retroactively applying D-MIST back onto the literature, more work is needed to confirm the generalizability of the framework. A draft version of the framework has been tested with engineering students and has received early feedback from some fellow researchers, but a more formal assessment of the framework has yet to be carried out. Future work, therefore, includes conducting a formal expert review of D-MIST and assessing how D-MIST is practically leveraged in the design process of new microintervention systems. The empirical work of developing D-MIST has thus far been limited to universities in Denmark and the United Kingdom; future work should therefore also aim to include experts from other contexts.</p>
        <p>Further opportunities to extend and validate the framework include applying it to a case study aiming to look at real data, to support physical microinterventions that have a more direct impact on users, such as the deployment of medications, or to include nonintrusive short measurements of the different levels of the framework.</p>
        <p>The D-MIST framework might additionally be useful for structuring the analysis and design related to privacy, security, and ethics, for instance, by going through components step by step and considering issues related to these topics. Considerations for events might, for example, include assessing their suitability for all targeted users (ie, universal design, inclusivity, and accessibility), and for triggers, assessing the impact of collecting past historical data and being able to track and assess the user’s current state. However, future works are needed to further explore these topics in relation to microinterventions and D-MIST.</p>
        <p>The number of interventions, study periods, and the number of participants in many of these studies is limited. Adding additional literature not focused on microinterventions would, however, have made our work less focused. Consequently, papers describing similar systems [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref107">107</xref>] without using the microintervention terminology and their insights are outside the scope of this work. We also did not exclude literature based on quality, which may have resulted in the inclusion of some “lower quality works.” However, we note in line with the CIS methodology that exclusion of literature should not be based on quality grounds alone, as such literature can inform, contribute to, and add to the richness of findings [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref108">108</xref>], and hence, we did not use a structured tool for assessment.</p>
        <p>While we have proposed an evidence-based framework (D-MIST) for microintervention systems, reasoning about scalable and engaging digital health interventions, several questions remain: first, given the relatively short duration of most microintervention studies, we know little about long-term use, distal effects, and the perspective of maintaining varied narratives in both short- and long-term. Most “long-term” studies on microinterventions are indeed relatively short compared to more traditional long-lasting behavior change studies where behaviors are to be maintained over years [<xref ref-type="bibr" rid="ref109">109</xref>]. The broader microintervention care life cycle and user experience over time may be key to understanding the wider requirements for microintervention systems. Second, we have uncovered relatively few microinterventions with clearly scoped decision rules and use contexts, making it difficult for designers of microintervention systems to leverage existing research, especially outside the reported uses. Even though more research is needed on both individual microinterventions, on the larger narrative applications, and in the exploration of the user experience, the D-MIST framework can be a helpful tool when structuring and describing microintervention systems.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Microinterventions hold the potential to engage users who would otherwise not commit to traditional interventions due to the effort required. To help the design, assessment, and scientific reasoning about microinterventions and their constituents, this paper has presented the D-MIST framework. D-MIST allows for classifying, designing, describing, and studying microinterventions, the systems providing them, and their embodied narratives. The framework is based on a review of state-of-the-art research on microinterventions and has consolidated, discussed, and specified definitions across a large body of evidence.</p>
        <p>The framework describes microinterventions, their components, assessments, and implications for the user experience of engaging with microintervention systems. This paper also documents the need for personalization and adaptability of events and their resources and delivery method, and discusses automation versus ownership and user agency. Explicit narratives have the potential to create more meaningful, effective systems with personalized and contextually relevant microinterventions. The studies included in this review support the notion that tailoring narratives to the individual can lead to increased effectiveness, exercise enjoyment, barrier reduction, and reduced attrition. Leveraging synergy between different microintervention and their effects for use in narratives seems key to supporting better long-term health outcomes.</p>
        <p>The D-MIST framework addresses the challenge of understanding how we can design technologies and apps that productively leverage multiple microinterventions in personalized narratives supporting not only short-term goals but also long-term health outcomes. Furthermore, the framework promotes an understanding of how different actors, collaboratively through their interactions, achieve the aims of microintervention systems.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Full search strategy, and database specific query, no filters or limits were applied to any database.</p>
        <media xlink:href="jmir_v27i1e72658_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 29 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Examples of micro-intervention systems and their components according to the D-MIST framework.</p>
        <media xlink:href="jmir_v27i1e72658_app2.png" xlink:title="PNG File , 1644 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>A proposed micro-intervention narrative with a narrative goal of increasing physical activity through various micro-intervention goals, based on a combination of micro-interventions and events found in existing literature. A detailed description of the narrative, micro-intervention goals and micro-interventions can be found below. A similar timeline could be used to highlight an individual narrative thread experienced by a user by including specific events.</p>
        <media xlink:href="jmir_v27i1e72658_app3.pdf" xlink:title="PDF File  (Adobe PDF File), 191 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Opportunities for Personalization.</p>
        <media xlink:href="jmir_v27i1e72658_app4.pdf" xlink:title="PDF File  (Adobe PDF File), 39 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Step by step example of a top-down design process for a hypothetical micro-intervention system aiming to increase physical activity.</p>
        <media xlink:href="jmir_v27i1e72658_app5.pdf" xlink:title="PDF File  (Adobe PDF File), 81 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>A monitoring-analysis-intervention (JIT) approach to creating personalized micro-intervention narratives.</p>
        <media xlink:href="jmir_v27i1e72658_app6.pdf" xlink:title="PDF File  (Adobe PDF File), 14 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BCT</term>
          <def>
            <p>behavior change technique</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">CIS</term>
          <def>
            <p>critical interpretive synthesis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">DBCI</term>
          <def>
            <p>digital behavior change intervention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">D-MIST</term>
          <def>
            <p>Design Framework for Microintervention Software Technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">EMI</term>
          <def>
            <p>ecological momentary intervention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">JIT</term>
          <def>
            <p>just-in-time</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">JITAI</term>
          <def>
            <p>Just-In-Time Adaptive Intervention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This research is part of the iPDM-GO project [<xref ref-type="bibr" rid="ref95">95</xref>] funded by the EU Horizon Europe: European Institute of Innovation and Technology Health (EIT Health). EIT Health is supported by the EIT, a body of the European Union that receives support from the European Union’s Horizon Europe research and innovation program. JEB and DRP are funded by the Copenhagen Center for Health Technology. ABanerjee, ABlandford, NK, and MR are funded by the National Institute of Health Research (grant NIHR200937). The funding sources made no contribution to the design, collection, analysis, and interpretation of data, in the writing of the report, or the decision to submit the paper for publication. The views expressed in this publication are those of the authors and not those of the funding sources. DRP was affiliated with the Department of Applied Mathematics and Computer Science, Technical University of Denmark, at the time of this work, and is currently affiliated with the Department of Computer Science at the University of Copenhagen. MR was affiliated with the Institute of Health Informatics, University College London, at the time of this work and is now affiliated with the Wolfson Institute of Population Health, Queen Mary University of London. NK was affiliated with the Institute of Health Informatics, University College London, at the time of this work, and is now affiliated with the Department of Primary Care and Public Health, Imperial College London.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>Conceptualization: DRP, PB, JEB, ABlandford</p>
        <p>Data curation: DRP, PB</p>
        <p>Formal analysis: DRP, PB, JEB, ABlandford</p>
        <p>Funding acquisition: JEB, PB</p>
        <p>Investigation: DRP, PB</p>
        <p>Methodology: DRP, PB, ABlandford, JEB</p>
        <p>Project administration: DRP</p>
        <p>Resources: DRP</p>
        <p>Supervision: PB, JEB, ABlandford</p>
        <p>Validation: DRP, MR, NK, ABanerjee, ABlandford, JEB, PB</p>
        <p>Visualization: DRP</p>
        <p>Writing—original draft: DRP, PB, ABlandford, JEB, MR, NK, ABanerjee</p>
        <p>Writing—review and editing: DRP, PB, ABlandford, JEB, MR, NK, ABanerjee</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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