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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e71795</article-id>
      <article-id pub-id-type="pmid">40435494</article-id>
      <article-id pub-id-type="doi">10.2196/71795</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Aligning With the Goals of the Planetary Health Concept Regarding Ecological Sustainability and Digital Health: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Hong</surname>
            <given-names>Yuxiang</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Elechi</surname>
            <given-names>Kelechi</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Adeoye</surname>
            <given-names>Adekunle</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Berger</surname>
            <given-names>Mathea</given-names>
          </name>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Human Medicine, Division of Didactics and Educational Research in Health Care</institution>
            <institution>Faculty of Health</institution>
            <institution>Witten/Herdecke University</institution>
            <addr-line>Alfred-Herrhausenstraße 54</addr-line>
            <addr-line>Witten, 58452</addr-line>
            <country>Germany</country>
            <phone>49 2302 92678625</phone>
            <email>mathea.berger@uni-wh.de</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0004-7323-6353</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Ehlers</surname>
            <given-names>Jan Peter</given-names>
          </name>
          <degrees>Dr Med Vet</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6306-4173</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Nitsche</surname>
            <given-names>Julia</given-names>
          </name>
          <degrees>Dr rer medic</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3443-6649</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Human Medicine, Division of Didactics and Educational Research in Health Care</institution>
        <institution>Faculty of Health</institution>
        <institution>Witten/Herdecke University</institution>
        <addr-line>Witten</addr-line>
        <country>Germany</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Mathea Berger <email>mathea.berger@uni-wh.de</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>28</day>
        <month>5</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e71795</elocation-id>
      <history>
        <date date-type="received">
          <day>9</day>
          <month>2</month>
          <year>2025</year>
        </date>
        <date date-type="rev-request">
          <day>26</day>
          <month>3</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>28</day>
          <month>4</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>30</day>
          <month>4</month>
          <year>2025</year>
        </date>
      </history>
      <copyright-statement>©Mathea Berger, Jan Peter Ehlers, Julia Nitsche. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.05.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e71795" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Climate change, driven by greenhouse gas emissions, threatens human health and biodiversity. While the digitalization of health care, including telemedicine and artificial intelligence, offers sustainability benefits, it also raises concerns about energy use and electronic waste. Balancing these factors is key to a sustainable health care future.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The objective of this review was to examine the extent to which digitalization in the health care sector influences environmental sustainability. Specifically, it aimed to assess how digitalization can contribute to reducing the health care sector’s impact on global climate change. From these findings, conclusions were drawn regarding the extent to which digitalization aligns with the objectives of the Planetary Health movement and how these 2 movements may mutually reinforce each other.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A scoping review guided by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines using databases such as PubMed and Scopus was conducted, and 58 quantitative studies from 2009 to 2024 were analyzed for environmental, social, and economic outcomes aligned with Planetary Health goals.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>This review analyzed 58 studies on the environmental impact of digitalization in health care primarily focusing on telemedicine, which was examined in 91% (53/58) of the studies. Most studies (56/58, 97%) quantified transport-related emissions avoided through digitalization, with some also assessing emissions from health care facilities, medical equipment, and energy consumption. Findings indicated that telemedicine significantly reduces carbon dioxide emissions, with total avoided emissions amounting to approximately 830 million kg. A substantial proportion of the studies (36/58, 62%) focused on social aspects, highlighting factors such as patient satisfaction, time efficiency, and overall convenience. In addition, economic considerations were analyzed in 48% (28/58) of the studies, emphasizing cost reductions and resource optimization. However, only 12% (7/58) of the studies evaluated the full life cycle impact of digital technologies, highlighting the need for further research on their long-term environmental sustainability.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>This review calls for further research beyond telemedicine, advocating for life cycle analyses and actionable strategies for a sustainable digitalization in health care systems. The Planetary Health framework is highlighted as a guide for ensuring sustainable digital transformation in health care.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>climate change</kwd>
        <kwd>digitalization</kwd>
        <kwd>sustainability</kwd>
        <kwd>Planetary Health</kwd>
        <kwd>environmental protection</kwd>
        <kwd>artificial intelligence</kwd>
        <kwd>AI</kwd>
        <kwd>PRISMA</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Health Care and Global Climate Change: Part of the Problem?</title>
        <p>Human-made climate change poses a global existential threat, bringing with it several challenges and problems. Extreme weather events, loss of biodiversity, and rising sea levels are just some of the many consequences of climate change [<xref ref-type="bibr" rid="ref1">1</xref>]. The primary cause for these catastrophic effects on the environment is the steadily rising mean near-surface temperature of the Earth. According to the Copernicus Climate Change Service, in September 2024, this was 1.54 °C above preindustrial levels [<xref ref-type="bibr" rid="ref2">2</xref>]. The major drivers of these developments are greenhouse gas emissions, particularly carbon dioxide (CO<sub>2</sub>) [<xref ref-type="bibr" rid="ref3">3</xref>]. The environmental changes associated with climate change affect human physical and mental health in various ways [<xref ref-type="bibr" rid="ref4">4</xref>]. Air pollution and increased exposure to extreme heat affect the respiratory and cardiovascular systems [<xref ref-type="bibr" rid="ref5">5</xref>]. Environmental changes manifest in forms such as malnutrition, increasing rates of infectious diseases [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>], and allergies, to name a few other health consequences [<xref ref-type="bibr" rid="ref8">8</xref>].</p>
        <p>However, the health sector is not only confronted with consequences for human health; it also contributes significantly to climate change itself, accounting for 4.4% of global annual CO<sub>2</sub> emissions [<xref ref-type="bibr" rid="ref9">9</xref>]. These emissions are primarily caused by the direct energy requirements of health care facilities [<xref ref-type="bibr" rid="ref10">10</xref>]. Furthermore, indirect emissions from the health care sector, including supply chains as well as the transportation of patients and staff to and from health care facilities, are particularly significant [<xref ref-type="bibr" rid="ref11">11</xref>]. Considering options to face this problem within the health care sector, digitalization is a promising approach to not only meet the challenges of climate change but also make the health care sector as a whole more sustainable [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
      </sec>
      <sec>
        <title>Digitalization in Health Care: Opportunity and Additional Risk</title>
        <p>Taking a closer look at digitalization in the health care sector, the use of telemedicine, artificial intelligence (AI), digital hospital information systems, and various other digital applications in the health care sector can be divided into 3 categories in relation to climate change according to Rahimi-Ardabili et al [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>The first category is digitalization to mitigate the impact of the health care sector on climate change. The targeted use of AI to optimize energy consumption, for example, significantly reduces the electricity consumption of health care facilities [<xref ref-type="bibr" rid="ref14">14</xref>]. Savings with digital technology use in the energy supply sector are estimated to be between 8% and 8.6% by 2030 [<xref ref-type="bibr" rid="ref15">15</xref>]. Furthermore, digitalization can facilitate faster and more accurate diagnoses of various diseases such as diabetes, cardiovascular diseases, and cancer, as well as preventive approaches and patient independence in managing diseases through technological assistance, thereby reducing resource consumption in the health care sector [<xref ref-type="bibr" rid="ref16">16</xref>]. Digital optimization of supply chains in the health care sector also promotes greater sustainability [<xref ref-type="bibr" rid="ref17">17</xref>]. Telemedicine and web-based consultations are associated with a significant reduction of CO<sub>2</sub> emissions caused by patient transportation, with savings ranging from 0.9 to 900 kg of CO<sub>2</sub> per consultation [<xref ref-type="bibr" rid="ref18">18</xref>]. They also contribute to better accessibility of health care facilities in remote areas and reductions in long-distance patient travel [<xref ref-type="bibr" rid="ref19">19</xref>].</p>
        <p>The second category is digitalization of the management of infectious diseases triggered by climate change. Emerging infectious diseases are a phenomenon exacerbated by climate change, environmental pollution, and population growth [<xref ref-type="bibr" rid="ref20">20</xref>]. Establishing new technologies is a decisive measure to counter the risk of infectious diseases triggered by climate change. Epidemiological analyses, tracking and simulation models, biosensors and geoinformation systems, and apps for smartphones [<xref ref-type="bibr" rid="ref21">21</xref>] help diagnose outbreaks of infection at an early stage; identify risk areas; and, thus, take preventive action [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>The third category is digitalization of the management of health risks caused by climate change. The use of digital technologies such as sensor technology and AI systems constitutes environmental monitoring systems that make it possible to monitor environmental quality and make predictions about potential health risks [<xref ref-type="bibr" rid="ref22">22</xref>]. For instance, air or water pollution [<xref ref-type="bibr" rid="ref13">13</xref>] can be detected early, and warnings can be issued via early warning systems [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Wearable sensors enable the assessment of individual health risks related to environmental factors. Digital technologies facilitate risk mapping to identify environmental factors impacting on health and allow for early detection of environmentally associated health incidents [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>Although digitalization is a promising strategy to make health care more environmentally sustainable [<xref ref-type="bibr" rid="ref13">13</xref>] and address the challenges posed by climate change impacts, the ecological impact of digitalization itself should not be overlooked [<xref ref-type="bibr" rid="ref25">25</xref>].</p>
        <p>The first impact is increasing energy consumption due to digitalization. CO<sub>2</sub> emissions from global information and communications technologies were estimated to be approximately 3.5% in 2020 [<xref ref-type="bibr" rid="ref26">26</xref>]. Digital technologies are also associated with increased energy consumption [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. The annual share of German energy demand from information and communications technology for 2030 is projected to be 7.4%, and according to some estimates, it could reach up to 9%. The energy required for the production of these technologies is more than twice the energy consumption caused by their use [<xref ref-type="bibr" rid="ref15">15</xref>].</p>
        <p>The second impact is increased resource requirements due to digitalization. In addition, the production of digital technologies requires large amounts of raw materials, which is problematic [<xref ref-type="bibr" rid="ref14">14</xref>]. The extraction of necessary natural resources (eg, iron, aluminum, gold, or mercury) leads to the destruction of the environment, loss of biodiversity, and serious health effects among workers in mining areas [<xref ref-type="bibr" rid="ref29">29</xref>].</p>
        <p>The third impact is the effects of digitalization with regard to problematic disposal structures. The disposal of digital technologies has a negative environmental impact, with electronic waste being the fastest-growing waste stream worldwide, reaching 62 billion kg in 2022. Digital devices such as smartphones, printers, and laptops account for 47% of this total [<xref ref-type="bibr" rid="ref30">30</xref>]. The challenge lies not only in the sheer amount of waste but also in the difficulty of recycling materials [<xref ref-type="bibr" rid="ref31">31</xref>] and improper disposal, leading to resource loss [<xref ref-type="bibr" rid="ref30">30</xref>] and severe environmental pollution, particularly in regions of the Global South [<xref ref-type="bibr" rid="ref25">25</xref>]. This mishandling has highly harmful effects on the health of workers and the local population [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p>
        <p>When examining the digitalization of health care through the lens of ecological sustainability, it is crucial to evaluate existing frameworks designed to promote environmental sustainability in the health care sector. The central question is how effectively these frameworks can be adopted for digitalization and whether they synergize to enhance sustainability or create obstacles to each other’s implementation.</p>
      </sec>
      <sec>
        <title>Digital Health and Planetary Health: Complement or Conflict?</title>
        <p>One of these efforts to make health care more sustainable is that of <italic>Planetary Health</italic>, which addresses the interdependencies between human health and the health of the planet. More precisely, it describes an integrative, interdisciplinary concept that considers Planetary Health at various levels—social, ecological, and economic [<xref ref-type="bibr" rid="ref33">33</xref>]. Planetary Health addresses not only the numerous environmental changes such as climate change, deforestation, loss of biodiversity, and environmental pollution but also the health effects of these changes [<xref ref-type="bibr" rid="ref34">34</xref>]. However, it is not just a concept; it serves as a guide for institutions to create policies that make the health care sector more environmentally sustainable [<xref ref-type="bibr" rid="ref35">35</xref>]. Planetary Health provides an excellent basis for addressing the interactions between the environmental impacts of the health care sector and human health [<xref ref-type="bibr" rid="ref36">36</xref>].</p>
        <p>If we consider the ecological dilemma of digitalization described previously against the backdrop of the <italic>Planetary Health</italic> concept, it must be questioned to what extent digitalization efforts themselves have a negative impact on the environment and human health and how these effects can be mitigated. Initial steps such as implementations of life cycle analyses (LCAs) [<xref ref-type="bibr" rid="ref37">37</xref>], approaches to the digital circular economy [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref31">31</xref>], green IT, and the development of policies and frameworks [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref38">38</xref>] for digitalization in terms of ecological sustainability already exist in the literature and are being discussed.</p>
        <p>To more precisely examine how digitalization in health care relates to the sustainability goals of Planetary Health and to what extent it supports or challenges these objectives, a scoping review was conducted. In addition, this review aimed to identify knowledge gaps in the literature regarding the measurement and assessment of ecological sustainability in this field. Through a comprehensive analysis of the existing body of research, this review sought to provide insights into areas in which further investigation is necessary to better understand the environmental impacts of health care digitalization and how it aligns with the sustainability objectives outlined by the Planetary Health concept. It should be examined whether the goals of the Planetary Health concept can be applied to the digitalization of health care and whether their implementation within a framework is feasible or whether they conflict with one another.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Search Strategy and Selection Criteria</title>
        <p>This scoping review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>) without being registered under a protocol. This review investigated the impact of digitalization in health care on achieving environmental sustainability goals within the Planetary Health framework. The key research questions (RQs) were as follows:</p>
        <list list-type="bullet">
          <list-item>
            <p>RQ1: What are the environmental benefits of health care digitalization?</p>
          </list-item>
          <list-item>
            <p>RQ2: What potential negative environmental impacts are associated with digitalization in health care?</p>
          </list-item>
          <list-item>
            <p>RQ3: How does digitalization align with Planetary Health’s sustainability goals?</p>
          </list-item>
        </list>
        <p>The PubMed, Scopus, and MEDLINE databases were used to identify relevant articles. Additional studies were incorporated through citation searches of pertinent literature. The search was conducted on August 14, 2024, and included all quantitative studies published up to that date. The search string comprised 3 main categories: “digitalization,” “sustainability/environmental effects,” and “healthcare,” tailored for each database using Boolean operators (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). The search was further restricted to titles and abstracts. An analysis of study quality was not conducted because it was prioritized to identify gaps and trends in the literature.</p>
        <p>The search aimed to identify quantitative primary data on the environmental impact of digitalization in the health care sector. The inclusion criteria were based on the population, intervention, comparison, and outcome framework [<xref ref-type="bibr" rid="ref41">41</xref>], requiring that studies meet all the categories shown in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>. To minimize bias from a single reviewer, the inclusion criteria were predefined in tandem.</p>
        <boxed-text id="box1" position="float">
          <title>Inclusion criteria showing the population, intervention, comparison, and outcome categories; further descriptions; and examples.</title>
          <list list-type="bullet">
            <list-item>
              <p>Population: all relevant groups in the health care sector affected by digitalization (eg, patients, employees, and health insurers)</p>
            </list-item>
            <list-item>
              <p>Intervention: any digital technology or digital process (eg, telemedicine, electronic health records, artificial intelligence, and digital applications)</p>
            </list-item>
            <list-item>
              <p>Comparison: comparisons involving older technology or traditional versus digital approaches (eg, digital vs nondigital and environmental impact before and after digitalization)</p>
            </list-item>
            <list-item>
              <p>Outcome: environmental impact attributed to digitalization in health care (eg, carbon dioxide emissions, greenhouse gas emissions, electronic waste, waste reduction, and reduction of environmental resources)</p>
            </list-item>
          </list>
        </boxed-text>
        <p>Search results were excluded if they were books, conference proceedings, editorials, or commentaries. Reviews and overview articles were not considered during the initial screening, but their citations were screened in a second step. Studies not relevant to the topic or lacking quantitative data were also excluded. Furthermore, papers in languages other than German or English were excluded.</p>
      </sec>
      <sec>
        <title>Data Analysis</title>
        <p>The studies retrieved from the literature search were uploaded to Rayyan (Qatar Computing Research Institute [<xref ref-type="bibr" rid="ref42">42</xref>]), and duplicates were automatically removed. The studies were initially screened by a single reviewer based on titles and abstracts according to the inclusion criteria. Studies in which uncertainties regarding the fulfillment of inclusion criteria arose were discussed with a second reviewer to mitigate the risk of single-reviewer bias. Uncertainty regarding the inclusion criteria was defined as a lack of clarity in at least one population, intervention, comparison, and outcome criterion.</p>
        <p>In cases of disagreement regarding study eligibility, the studies were initially included in the full-text screening to allow for a more thorough assessment. If consensus was reached on inclusion or exclusion, the studies were either included or excluded accordingly. Studies deemed suitable for full-text screening were uploaded to Rayyan again. The full-text screening was conducted following the same procedure as for the abstract screening. Studies for which there were disagreements regarding the fulfillment of inclusion criteria were discussed until consensus was reached. All included and excluded studies were reviewed and validated by a second reviewer to minimize the risk of single-reviewer bias.</p>
        <p>Data were analyzed according to predefined categories developed by the 2 reviewers. The following information was compiled in a Microsoft Excel spreadsheet (Microsoft Corp): author, year, country, study design, aims, and objectives. In addition, secondary outcomes such as social and economic impacts were recorded. Social outcomes included effects on patients and staff, such as satisfaction, experience, and health outcomes. The economic impact was defined as the financial effect on the health care system or patients. These aspects were considered to analyze, in line with the holistic approach of the Planetary Health concept, how many studies already adopt a more comprehensive, integrated perspective on the topic of sustainability. Other categories included the digital technology examined, application of LCA, and the method of calculating the ecological impact of the digital technology assessed. Calculations for <italic>nondigital</italic> or traditional alternatives were also recorded. Finally, data on the environmental impacts were examined, and their results were compiled. The extraction was conducted by 1 reviewer and discussed collaboratively to validate the extracted data.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Characteristics and Methodological Approaches</title>
        <p>The search yielded a total of 772 hits. After excluding duplicates, of the 772 hits, 444 (57.5%) abstracts were screened, and 151 (19.6%) abstracts were double screened with the second reviewer because of uncertainties. In this step, of the 444 abstracts screened, a total of 137 (30.9%) studies were excluded jointly, and 5 (1.1%) studies were included. Due to disagreements, 2% (9/444) of the studies were included in the full-text screening, resulting in a total of 71 studies included in the full-text screening. Of these 71 studies, 10 (14%) were inaccessible and, therefore, excluded. From the database search, 59% (36/61) of the studies were included in the data extraction, and 41% (25/61) were excluded with specified reasons according to the exclusion criteria. After a collaborative discussion on 25 studies, 17 (68%) were excluded based on predefined criteria, and 8 (32%) were selected for inclusion. An additional 22 studies were identified through citation tracking. In total, 58 studies were analyzed and included in the review (<xref rid="figure1" ref-type="fig">Figure 1</xref>). The results, sorted by the defined categories, are provided in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA 2020 flow diagram for new systematic reviews that includes searches of databases, registers, and other sources.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e71795_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Included studies analyzed by the defined categories.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="120"/>
            <col width="90"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="110"/>
            <col width="70"/>
            <col width="90"/>
            <col width="90"/>
            <col width="130"/>
            <thead>
              <tr valign="bottom">
                <td>Study, country, year</td>
                <td>Setting (dept)</td>
                <td>Aims and objectives</td>
                <td>Digital Technology</td>
                <td>Data<sup>a</sup></td>
                <td>Tool</td>
                <td>Factors<sup>b</sup></td>
                <td>Tool—LCA<sup>c</sup></td>
                <td>Outcome<sup>d</sup></td>
                <td>Key findings</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Curtis et al [<xref ref-type="bibr" rid="ref43">43</xref>], United Kingdom, 2021</td>
                <td>Hospital (orthopedics)</td>
                <td>Evaluating the impact of NF2F<sup>e</sup> versus F2F<sup>f</sup> emergency orthopedic clinic referrals</td>
                <td>Telemedicine (T<sup>g</sup>)</td>
                <td>Travel-related emissions and building emissions</td>
                <td>Travel-related emissions: UK DEFRA<sup>h</sup>; building emissions: NHS<sup>i</sup> Sustainable Development Unit</td>
                <td>None</td>
                <td>NA<sup>j</sup></td>
                <td>Carbon emissions (CO<sub>2</sub><sup>k</sup>)</td>
                <td>Avoided emissions per NF2F consultation: 56 kg of CO<sub>2</sub>; avoided emissions in total for 104 NF2F consultations: 5846 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Heffernan et al [<xref ref-type="bibr" rid="ref44">44</xref>], Canada, 2023</td>
                <td>Hospital (pediatrics)</td>
                <td>Evaluating potential carbon savings of NF2F versus F2F in OSA<sup>l</sup> and OM<sup>m</sup>with effusion surgery care</td>
                <td>Telemedicine (VC<sup>n</sup>)</td>
                <td>Travel-related emissions</td>
                <td>Canada’s National GHG<sup>o</sup> Inventory Report</td>
                <td>EEC<sup>p</sup> and OEC<sup>q</sup> (D<sup>r</sup>)</td>
                <td>EEC: NA; OEC: Government of British Columbia</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 63.86 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Holmner et al [<xref ref-type="bibr" rid="ref19">19</xref>], Sweden, 2014</td>
                <td>University hospital (surgery)</td>
                <td>Evaluating the carbon footprint of NF2F hand and plastic surgery rehabilitation appointments</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Lenzen [<xref ref-type="bibr" rid="ref45">45</xref>]</td>
                <td>EEC and OEC (D, DT<sup>s</sup>, and SR<sup>t</sup>)</td>
                <td>EEC: LCA (Ong et al [<xref ref-type="bibr" rid="ref46">46</xref>]); OEC: NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 238 NF2F consultations: 602 kg of CO<sub>2</sub>; 1.86-8.43 kg of CO<sub>2</sub> per hour of web-based consultation</td>
              </tr>
              <tr valign="top">
                <td>Smith et al [<xref ref-type="bibr" rid="ref47">47</xref>], United Kingdom, 2013</td>
                <td>Nationwide health care sector</td>
                <td>Evaluating the carbon emissions associated with different smoking cessation support methods, including SMS text message support and telephone, group, and individual counseling</td>
                <td>Telemedicine (NS<sup>u</sup>)</td>
                <td>Travel-related emissions and building emissions</td>
                <td>NIHR<sup>v</sup></td>
                <td>Travel-related emissions: EEC; building emissions: OEC</td>
                <td>Travel-related emissions: Mobile’s Green Manifesto; building emissions: UK DEFRA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per 1000 patients for SMS text messages: 8143 kg of CO<sub>2</sub>; emissions per 1000 patients for telephone counseling: 8619 kg of CO<sub>2</sub>; emissions per 1000 patients for group counseling: 16,114 kg of CO<sub>2</sub>; emissions per 1000 patients for individual counseling: 16,372 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Connor et al [<xref ref-type="bibr" rid="ref48">48</xref>], United Kingdom, 2011</td>
                <td>University hospital (nephrology)</td>
                <td>Evaluating travel-related reduction in GHG emissions of telephone consultations for routine follow-up care for patients undergoing renal transplantation</td>
                <td>Telemedicine (T)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and UK DEFRA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 350 NF2F consultations: 2818 kg of CO<sub>2</sub>; avoided emissions in total for 350 NF2F consultations+staff travel: 3049 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Kassa et al [<xref ref-type="bibr" rid="ref49">49</xref>], Sweden, 2024</td>
                <td>Hospital (pediatrics)</td>
                <td>Evaluating NF2F versus F2F consultations according to potential travel-related carbon savings</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and online CO<sub>2</sub> calculator</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per family: 126.3 kg of CO<sub>2</sub>; median 267 km traveled</td>
              </tr>
              <tr valign="top">
                <td>Savoldelli et al [<xref ref-type="bibr" rid="ref50">50</xref>], Italy, 2024</td>
                <td>University hospital (cardiology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F follow-up care</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions, waste, and digital device</td>
                <td>Travel-related emissions: ISO<sup>w</sup> 14040/14044 and Ecological Footprint Calculator; waste: ISO 14040/14044; digital device: ecoinvent version 3.8 and Ecological Footprint Calculator</td>
                <td>Travel-related emissions: EEC (D and SR); waste and digital device: OEC (D and SR)</td>
                <td>Travel-related emissions: ecoinvent version 3.8 and Ecological Footprint Calculator; waste and digital device:<break/>ISO 14040/14044 and Sillcox et al [<xref ref-type="bibr" rid="ref51">51</xref>]</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>NF2F emissions per patient: 0.41 kg of CO<sub>2</sub>; F2F emissions per patient: 9.77 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Tselapedi-Sekeitto et al [<xref ref-type="bibr" rid="ref52">52</xref>], Canada, 2024</td>
                <td>Hospital (otolaryngology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA<sup>x</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F consultation: mean 32 (SD 39) kg of CO<sub>2</sub> equivalent; avoided emissions in total for 33 NF2F consultations: mean 1056 (SD 224) kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Welk et al [<xref ref-type="bibr" rid="ref53">53</xref>], Canada, 2022</td>
                <td>Regional health care sector</td>
                <td>Evaluating the environmental and patient-level financial benefits of widespread NF2F care</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>IEA<sup>y</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 63,556,271 NF2F consultations in 22 mo (on 3,197,099,600 km traveled): 658 million kg of CO<sub>2</sub>; avoided emissions for 10% use of public transit: 589 million kg of CO<sub>2</sub>; avoided emissions for 20% use of public transit: 545 million kg of CO<sub>2</sub>; avoided emissions per NF2F visit for 10% use of public transit: 9.3 kg of CO<sub>2</sub>; avoided emissions per NF2F visit for 20% use of public transit: 8.4 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Dorrian et al [<xref ref-type="bibr" rid="ref54">54</xref>], Scotland, 2009</td>
                <td>Primary health care</td>
                <td>Evaluating the feasibility and impact of NF2F versus F2F endoscopy</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>UK DEFRA and AA Route Planner</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F patient: 123 kg of CO<sub>2</sub> equivalent (round trip)</td>
              </tr>
              <tr valign="top">
                <td>Thiel et al [<xref ref-type="bibr" rid="ref55">55</xref>], United States, 2023</td>
                <td>University hospital (all)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions, building emissions, and medical equipment</td>
                <td>US EPA</td>
                <td>Travel-related emissions: EEC; building emissions and medical equipment: OEC</td>
                <td>Travel-related emissions: ISO 14040/14044, LCA SimaPro 9.3.0.240 LCI<sup>z</sup> database, and ecoinvent version 3.82; building emissions and medical equipment: US EPA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per NF2F consultation: 0.02-0.04 kg of CO<sub>2</sub> equivalent; emissions per F2F consultation: 20 kg of CO<sub>2</sub> equivalent; avoided emissions in total per y: 17,000 metric tons of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Morcillo Serra et al [<xref ref-type="bibr" rid="ref56">56</xref>], Spain, 2022</td>
                <td>Insurance company</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC) and EHR<sup>aa</sup></td>
                <td>Travel-related emissions and paper use (energy for printing)</td>
                <td>Carbon Trust</td>
                <td>OEC (D and DT)</td>
                <td>Carbon Trust</td>
                <td>GHG emissions</td>
                <td>Avoided emissions per NF2F consultation: 3.057 kg of CO<sub>2</sub> equivalent; avoided emissions in total for NF2F and download of medical reports: 6,655,000 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Jiang et al [<xref ref-type="bibr" rid="ref57">57</xref>], United States, 2021</td>
                <td>Nationwide health care sector (oncology)</td>
                <td>Evaluating NF2F services and estimating the financial and environmental impacts of these services compared to F2F visits</td>
                <td>Telemedicine (T and VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 560 NF2F consultations: 35,500 kg of CO<sub>2</sub> per 3 mo (on 139,160 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Cummins et al [<xref ref-type="bibr" rid="ref58">58</xref>], United States, 2024</td>
                <td>Nationwide health care sector</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA and ArcGIS</td>
                <td>OEC (D and DT)</td>
                <td>US EPA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 19.821 kg of CO<sub>2</sub> equivalent; avoided emissions in total for 6,231,614 NF2F consultations: 123,461,000 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Grabski et al [<xref ref-type="bibr" rid="ref59">59</xref>], United States, 2024</td>
                <td>Hospital (pediatrics)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 20,845 NF2F consultations: 618,000 kg of CO<sub>2</sub> (1,562,716 miles traveled), 5400 kg of carbon monoxide, 670 kg of nitric oxide, and 6100 kg of volatile organic compounds</td>
              </tr>
              <tr valign="top">
                <td>Lewis et al [<xref ref-type="bibr" rid="ref60">60</xref>], Wales, 2009</td>
                <td>Hospital</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>UK DEFRA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 21 NF2F consultations per y: 1696 kg of CO<sub>2</sub>; avoided emissions in total for 30 NF2F consultations per y: 2590 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Evers et al [<xref ref-type="bibr" rid="ref61">61</xref>], United States, 2021</td>
                <td>Hospital (infectiology)</td>
                <td>Evaluating NF2F versus F2F impact on various costs and benefits related to health care visits</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F patient: average of 91.79 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Arndt et al [<xref ref-type="bibr" rid="ref62">62</xref>], Germany, 2023</td>
                <td>University hospital (orthopedics)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>TREMOD<sup>ab</sup></td>
                <td>OEC (SR)</td>
                <td>UBA<sup>ac</sup></td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per NF2F consultation: 0.004 kg of CO<sub>2</sub> equivalent; emissions per F2F consultation: 500 kg of CO<sub>2</sub> equivalent (average of 33 km traveled); avoided emissions in total per y: 17,000 tons of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Cockrell et al [<xref ref-type="bibr" rid="ref63">63</xref>], United States, 2022</td>
                <td>Hospital (pediatrics)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>R Core Team and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 10,626 NF2F consultations per y: 344,000 kg of CO<sub>2</sub> (1,427,497 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Sellars et al [<xref ref-type="bibr" rid="ref64">64</xref>], Scotland, 2020</td>
                <td>Hospital (gastroenterology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>AA Route Planner, UN<sup>ad</sup> ICAO<sup>ae</sup>, and Map My Emissions</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 42.27 kg of CO<sub>2</sub> equivalent; avoided emissions in total for 6685 NF2F consultations: 2113.29 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Al Fannah et al [<xref ref-type="bibr" rid="ref65">65</xref>], Oman, 2022</td>
                <td>Nationwide health care sector</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations and inhalation anesthetic gases</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Ravindrane and Patel [<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 0.69-190 kg of CO<sub>2</sub> equivalent; avoided emissions in total for 18,332 NF2F consultations: 12.65-3483.1 tons of CO<sub>2</sub>; avoided emissions in total for 34,792 NF2F consultations: 24-6610.5 tons of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Robinson et al [<xref ref-type="bibr" rid="ref67">67</xref>], United States, 2017</td>
                <td>Specialized health center (pediatrics)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F preoperative screenings for SPML<sup>af</sup> surgery</td>
                <td>Telemedicine (T)</td>
                <td>Travel-related emissions</td>
                <td>ArcGIS and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 161 NF2F patients: 43,595 kg of CO<sub>2</sub> equivalent (170,703 km traveled); avoided emissions in total for 161 NF2F consultations per y: 14,532 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Chang et al [<xref ref-type="bibr" rid="ref68">68</xref>], United States, 2023</td>
                <td>Hospital (surgery)</td>
                <td>The study aimed to assess the patient cost burden and environmental impact of travel versus telehealth for general surgery outpatient visits before and during the COVID-19 pandemic</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions for 307 NF2F visits before the COVID-19 pandemic: 81,590 kg of CO<sub>2</sub>; avoided emissions for 3256 NF2F visits during the COVID-19 pandemic: 481,341 kg of CO<sub>2</sub>; avoided emissions for 2949 NF2F visits (difference between the 2 periods): 399,751 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Muschol et al [<xref ref-type="bibr" rid="ref69">69</xref>], Germany, 2022</td>
                <td>University hospital (orthopedics)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F follow-ups</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>UBA</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions per NF2F consultation: GHGs—11.25 kg of CO<sub>2</sub> equivalent, 0.07 kg of carbon monoxide, 0.011 kg of volatile hydrocarbons, 0.028 kg of nitrogen oxides, and 0.0004 kg of particulates; avoided emissions in total for 26 NF2F consultations: GHGs—292.45 kg of CO<sub>2</sub> equivalent, 1.82 kg of carbon monoxide, 0.29 kg of volatile hydrocarbons, 0.73 kg of nitrogen oxides, and 0.01 kg of particulates</td>
              </tr>
              <tr valign="top">
                <td>Vidal-Alaball et al [<xref ref-type="bibr" rid="ref70">70</xref>], Spain, 2019</td>
                <td>Nationwide health care sector</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and Ministry of Territory, Housing, and Ecological Transition</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 9034 NF2F consultations: 29,384 kg of CO<sub>2</sub> (on 192,682 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>King et al [<xref ref-type="bibr" rid="ref71">71</xref>], United Kingdom, 2022</td>
                <td>Hospital (gastroenterology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (T)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and UK BEIS<sup>ag</sup></td>
                <td>OEC</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F consultation: 1.54 kg of CO<sub>2</sub> equivalent; emissions per NF2F consultation: 0.005 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Lee et al [<xref ref-type="bibr" rid="ref72">72</xref>], United States, 2021</td>
                <td>University hospital (dermatology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F isotretinoin management visits</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps, US EPA, and FHWA<sup>ah</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided e emissions for 710 NF2F consultations per y: 47,900 kg of CO<sub>2</sub>, 50.0 kg of methane, 41,395 kg of nitrous oxide, and 1040 kg of hydrofluorocarbons; total: 49,400 kg</td>
              </tr>
              <tr valign="top">
                <td>Patel et al [<xref ref-type="bibr" rid="ref73">73</xref>], United States, 2023</td>
                <td>Specialized health center (oncology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation with a driving time of ≤60 min: 19.8 kg of CO<sub>2</sub> equivalent (on a median of 77.41 km traveled); avoided emissions per NF2F consultation with a driving time of &#62;60 min: 98.6 kg of CO<sub>2</sub> equivalent (on a median of 385.92 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Dieperink et al [<xref ref-type="bibr" rid="ref74">74</xref>], Denmark, 2023</td>
                <td>University hospital (oncology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 37.9 kg of CO<sub>2</sub> equivalent (on a median of 120 km traveled); avoided emissions in total for 84 NF2F consultations: 3183.31 kg of CO<sub>2</sub> equivalent (on 12,877 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Schmitz-Grosz et al [<xref ref-type="bibr" rid="ref75">75</xref>], Germany and Switzerland, 2023</td>
                <td>Insurance company</td>
                <td>Evaluating the environmental impact of NF2F versus F2F health care model in Switzerland</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Mobitool and Federal Office for Spatial Development</td>
                <td>OEC (D, duration, and SR) and building emissions</td>
                <td>UBA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 0.57 kg of CO<sub>2</sub> equivalent (on an average of 4.15 km traveled); avoided emissions in total for 433,890 consultations: 248.48 tons of CO<sub>2</sub> equivalent (on 1,800,391 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Iaccarino et al [<xref ref-type="bibr" rid="ref76">76</xref>], United States, 2022</td>
                <td>University hospital (rehabilitation)</td>
                <td>Evaluating the environmental impact and benefits of NF2F versus F2F rehabilitation visits</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 212 NF2F consultations: 16.67 kg of volatile organic gases, 12.94 kg of nitrogen oxides, 161.24 kg of carbon monoxide, 6993.048 kg of CO<sub>2</sub>; PM10<sup>ai</sup>: 0.067 kg; PM2.5<sup>aj</sup>: 0.061 kg</td>
              </tr>
              <tr valign="top">
                <td>Barakat-Johnson et al [<xref ref-type="bibr" rid="ref77">77</xref>], Australia, 2022</td>
                <td>Specialized health center (dermatology)</td>
                <td>Assessing the viability and acceptability of an eWCC<sup>ak</sup> supported by a digital wound management application</td>
                <td>Digital application</td>
                <td>Travel-related emissions</td>
                <td>Google maps and Green Vehicle Guide</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions for 51 NF2F visits: 250 kg of CO<sub>2</sub> (on an average of 638 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Connor et al [<xref ref-type="bibr" rid="ref78">78</xref>], United Kingdom, 2019</td>
                <td>Hospital (urology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and Carbon Footprint</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 1008 NF2F consultations: 700-2930 kg of CO<sub>2</sub> equivalent (on 15,085 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Milne-Ives et al [<xref ref-type="bibr" rid="ref79">79</xref>], United Kingdom, 2022</td>
                <td>Hospital</td>
                <td>Evaluating the clinical and environmental impact of MyPreOp, a cloud-based preoperative assessment platform, in comparison to traditional preoperative procedures</td>
                <td>Web platform</td>
                <td>Travel-related emissions</td>
                <td>Carbon Footprint</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 813 NF2F consultations per 4 mo: 9050 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Moncho-Santonja et al [<xref ref-type="bibr" rid="ref80">80</xref>], Spain, 2023</td>
                <td>Hospital</td>
                <td>Evaluating the environmental impact of NF2F versus F2F follow-up consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions per NF2F consultations (on an average of 20.7 km traveled): 3.678 kg of CO<sub>2</sub> equivalent, 3.652 kg of CO<sub>2</sub>, 0.0034 kg of methane, and 0.0226 kg of nitrous oxide; avoided emissions in total for 21,548 NF2F consultations: 79,260.27 kg of CO<sub>2</sub> equivalent, 78,699.41 kg of CO<sub>2</sub>, 74.52 kg of methane, and 487.27 kg of nitrous oxide</td>
              </tr>
              <tr valign="top">
                <td>Turley et al [<xref ref-type="bibr" rid="ref81">81</xref>], United States, 2011</td>
                <td>Nationwide health care sector</td>
                <td>Evaluate the environmental impact of Kaiser Permanente’s EHR system</td>
                <td>EHR</td>
                <td>Travel-related emissions</td>
                <td>ArcGIS</td>
                <td>EEC and OEC (D)</td>
                <td>EcoHealth Footprint framework</td>
                <td>GHGs, waste, toxic chemicals, water use, air pollutants, and use of land for buildings</td>
                <td>Avoided emissions through paper elimination: 21,800 tons of CO<sub>2</sub> per y; avoided emissions through NF2F consultations (26% reduction in in-person visits): 26,000-92,000 tons of CO<sub>2</sub> per y; emissions produced by hardware and data center: 37,229,505 kg of CO<sub>2</sub> equivalent; avoided plastic waste by digitalizing x-ray images: 68 tons of plastic waste per y; emissions produced by e-waste: 6313-7892 tons of CO<sub>2</sub> equivalent (135 tons of plastic waste); avoided silver and silver nitrate by digitalizing x-ray images: 4.3 tons of silver per y and 6.8 tons of silver nitrate per y; avoided hydroquinone by digitalizing x-ray images: 26.5 tons per y; avoided water use by digitalizing x-ray images: 270,656,943 L per y; impact on emissions produced by EHRs: positive net effect—1,840,000-2,300,000 tons of CO<sub>2</sub> equivalent and negative net effect—720,000-900,000 tons of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Andrew et al [<xref ref-type="bibr" rid="ref82">82</xref>], Australia, 2020</td>
                <td>University hospital (nephrology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>US EPA and GNAF<sup>al</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 263 NF2F consultations: 51,000 kg of CO<sub>2</sub> equivalent (on 203,202 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Dullet et al [<xref ref-type="bibr" rid="ref83">83</xref>], United States, 2017</td>
                <td>University hospital</td>
                <td>Evaluating the environmental impact of NF2F versus hypothetical F2F consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>US EPA and MP Mileage 2.5</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 38,051 NF2F consultations (on 8,602,912.51 km traveled): 1,969,000 kg of CO<sub>2</sub>, 50 tons of carbon monoxide, 3.7 tons of nitrogen oxides, and 5.5 tons of volatile organic compounds</td>
              </tr>
              <tr valign="top">
                <td>Carr and Kevitt [<xref ref-type="bibr" rid="ref84">84</xref>], Ireland, 2023</td>
                <td>Hospital (occupational health)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (T)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and SEAI<sup>am</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 66 NF2F consultations: 305.6 kg of CO<sub>2</sub> equivalent (on 2029.2 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Bove et al [<xref ref-type="bibr" rid="ref85">85</xref>], United States, 2023</td>
                <td>University hospital (neurology)</td>
                <td>Evaluating the cost-effectiveness and data quality of NF2F versus F2F disability assessments for patients with multiple sclerosis</td>
                <td>Telemedicine (VC)</td>
                <td>No</td>
                <td>NA</td>
                <td>OEC (DT)</td>
                <td>Utility Bidder (1080p video at 0.015 kg per h)</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F visit: mean 89 kg of CO<sub>2</sub>; emissions per NF2F visit: mean 0.018 kg of CO<sub>2</sub></td>
              </tr>
              <tr valign="top">
                <td>Lathan et al [<xref ref-type="bibr" rid="ref86">86</xref>], United Kingdom, 2024</td>
                <td>Specialized health center (surgery)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F postoperative follow-up consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Building emissions, staff service, medical equipment, and pharmaceuticals</td>
                <td>Building emissions: UK DEFRA and UK NIHR; staff service: UK PSSRU<sup>an</sup>; medical equipment: NA; pharmaceuticals: NA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 41.2 kg of CO<sub>2</sub> equivalent (on a median of 42.5 km traveled); avoided emissions in total for 31 NF2F consultations: 1594 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Wolf et al [<xref ref-type="bibr" rid="ref10">10</xref>], United States, 2022</td>
                <td>NS (ophthalmology)</td>
                <td>To compare the marginal GHG emissions of conducting a diabetic eye examination using autonomous AI<sup>ao</sup> versus a traditional eye care provider</td>
                <td>AI</td>
                <td>Diabetic eye examination by an ophthalmologist</td>
                <td>US EPA</td>
                <td>OEC</td>
                <td>US EPA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per AI diagnostic examination: 0.02-0.2 g of CO<sub>2</sub> equivalent; total emissions including additional in-person examination: 0.16 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Mojdehbakhsh et al [<xref ref-type="bibr" rid="ref87">87</xref>], United States, 2021</td>
                <td>Hospital (gynecology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F outpatient gynecologic oncology consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 193 NF2F consultations per week: 6250 kg of CO<sub>2</sub> equivalent (on 24,964 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Sillcox et al [<xref ref-type="bibr" rid="ref51">51</xref>], United States, 2023</td>
                <td>Hospital (gastroenterology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions, medical equipment, and paper use</td>
                <td>Travel-related emissions: Holmner et al [<xref ref-type="bibr" rid="ref19">19</xref>] and ecoinvent; medical equipment: LCA and ecoinvent; paper use: NA</td>
                <td>OEC (DT and SR)</td>
                <td>ecoinvent</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F consultation: 38.22-39.61 kg of CO<sub>2</sub> equivalent; emissions per NF2F consultation: 2.22-2.9 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Sillcox et al [<xref ref-type="bibr" rid="ref88">88</xref>], United States, 2023</td>
                <td>Hospital (surgery)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F consultation: 201 kg of CO<sub>2</sub> equivalent; emissions per NF2F consultation: 36.6 kg of CO<sub>2</sub> equivalent; emissions in total for 51 F2F consultations per y: 10,225 kg of CO<sub>2</sub> equivalent (on 40,733 km traveled); avoided emissions in total for 55 NF2F consultations per y: 2011.4 kg of CO<sub>2</sub> equivalent (on 8013 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Thota et al [<xref ref-type="bibr" rid="ref89">89</xref>], United States, 2020</td>
                <td>Hospital (oncology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F patient: 1334 kg of CO<sub>2</sub> equivalent (in 4 y on 4596 km traveled); avoided emissions in total for 1025 NF2F consultations: 158,673 kg of CO<sub>2</sub> equivalent (in 4 y on 547,125 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Wootton et al [<xref ref-type="bibr" rid="ref90">90</xref>], Scotland, 2010</td>
                <td>Regional health care sector</td>
                <td>Evaluating the environmental impact of NF2F visits on reducing travel-related carbon emissions within the NHS</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>UK DEFRA</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO2)</td>
                <td>Avoided emissions in total for 2061 NF2F visits: 59,000 kg of CO<sub>2</sub> per y (on 260,000 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Blenkinsop et al [<xref ref-type="bibr" rid="ref91">91</xref>], United Kingdom, 2021</td>
                <td>University hospital (neurology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations in patients with epilepsy</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>ArcGIS, Google Maps, and UK BEIS</td>
                <td>OEC (D and DT)</td>
                <td>UK BEIS and Aslan et al [<xref ref-type="bibr" rid="ref92">92</xref>]</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 1277 NF2F consultations: 35,000-41,088 kg of CO<sub>2</sub> equivalent; emissions in total for 1277 NF2F consultations: 2 (telephone)-167 (VC) kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Miah et al [<xref ref-type="bibr" rid="ref93">93</xref>], United Kingdom, 2019</td>
                <td>Hospital (urology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>UK DfT<sup>ap</sup>, Google Maps, and Carbon Footprint</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 409 NF2F consultations: 350-1450 kg of CO<sub>2</sub> equivalent (median 3.8 miles traveled); projected avoided emissions in total for 409 NF2F consultations per y: 1050-4350 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Paquette and Lin [<xref ref-type="bibr" rid="ref94">94</xref>], United States, 2019</td>
                <td>Hospital (surgery)</td>
                <td>Evaluating the environmental and financial impacts of NF2F versus F2F consultations</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and US EPA</td>
                <td>None</td>
                <td>NA</td>
                <td>GHG emissions</td>
                <td>Avoided emissions in total for 146 NF2F consultations: 1632 kg of CO<sub>2</sub>, 0.043 kg of carbon monoxide, 3.160 kg of nitric oxides, and 4.715 kg of volatile organic compounds</td>
              </tr>
              <tr valign="top">
                <td>Peters et al [<xref ref-type="bibr" rid="ref95">95</xref>], United Kingdom, 2020</td>
                <td>University hospital (radiology)</td>
                <td>Evaluating the environmental impact of travel by radiology trainees and assessing the potential of remote work and tele-radiology</td>
                <td>Remote work</td>
                <td>Travel-related emissions</td>
                <td>ClimateCare</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions produced by working in person per trainee: 1850 kg of CO<sub>2</sub> per y (average of 6600 miles per y); avoided emissions with remote (PROC<sup>aq</sup>) setup in total: 4300 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Bartlett and Keir [<xref ref-type="bibr" rid="ref96">96</xref>], United Kingdom, 2022</td>
                <td>Hospital</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations during the COVID-19 pandemic</td>
                <td>Telemedicine (T and VC)</td>
                <td>Travel-related emissions, building emissions, and medical equipment</td>
                <td>Travel-related emissions: Google Maps and UK DEFRA; building emissions: UK DEFRA; medical equipment: Rizan et al [<xref ref-type="bibr" rid="ref97">97</xref>]</td>
                <td>Travel-related emissions: OEC; building emissions and medical equipment: EEC</td>
                <td>Travel-related emissions: NA; building emissions and medical equipment: LCA (Ong et al [<xref ref-type="bibr" rid="ref46">46</xref>])</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Emissions per F2F consultation: 4.824 kg of CO<sub>2</sub> equivalent; emissions per NF2F consultation: 0.994 kg of CO<sub>2</sub> equivalent</td>
              </tr>
              <tr valign="top">
                <td>Croghan et al [<xref ref-type="bibr" rid="ref98">98</xref>], Ireland, 2021</td>
                <td>Hospital (urology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F consultations in a urological outpatient setting</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>AA Route Planner, Google Maps, and Carbon Footprint</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 736 NF2F consultations: 6070 kg of CO<sub>2</sub> equivalent (49,951 km traveled in 3 mo)</td>
              </tr>
              <tr valign="top">
                <td>Oliveira et al [<xref ref-type="bibr" rid="ref99">99</xref>], Portugal, 2013</td>
                <td>Specialized health center</td>
                <td>Evaluating the environmental impact of NF2F versus F2F appointments</td>
                <td>Telemedicine (VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps, UK DEFRA, and UK DECC<sup>ar</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 22 kg of CO<sub>2</sub> equivalent; avoided emissions in total for 20,824 NF2F consultations: 455,000 kg of CO<sub>2</sub> equivalent (2,313,819 km traveled in 8 y)</td>
              </tr>
              <tr valign="top">
                <td>Gupta et al [<xref ref-type="bibr" rid="ref100">100</xref>], United Kingdom, 2023</td>
                <td>Hospital (otolaryngology)</td>
                <td>Assessing the effectiveness of and satisfaction with remote telephone consultations for patients referred for potential tonsillectomy</td>
                <td>Telemedicine (T)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps and UK BEIS</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions for 33 NF2F visits: mean 5.17 kg of CO<sub>2</sub> equivalent; avoided emissions for 16 NF2F visits: 8.77 kg of CO<sub>2</sub> equivalent (on a mean of 39.48 km traveled by car); avoided emissions for 11 NF2F visits: 1.31 kg of CO<sub>2</sub> equivalent (on a mean of 8.86 km traveled by bus); avoided emissions for 3 NF2F visits: 5.35 kg of CO<sub>2</sub> equivalent (on a mean of 121.2 km traveled by train)</td>
              </tr>
              <tr valign="top">
                <td>Schulz et al [<xref ref-type="bibr" rid="ref101">101</xref>], Australia, 2020</td>
                <td>Hospital (infectiology)</td>
                <td>Evaluating the effectiveness and environmental impact of NF2F versus F2F hepatitis C outreach services</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>BITRE<sup>as</sup></td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 58 NF2F consultations: 22,370 kg of CO<sub>2</sub> equivalent per y</td>
              </tr>
              <tr valign="top">
                <td>Udayaraj et al [<xref ref-type="bibr" rid="ref102">102</xref>], United Kingdom, 2019</td>
                <td>Hospital (nephrology)</td>
                <td>Implementing and evaluating an NF2F clinic service for patients undergoing kidney transplant; environmental impact versus F2F was evaluated</td>
                <td>Telemedicine (NS)</td>
                <td>Travel-related emissions</td>
                <td>National Energy Foundation</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions in total for 97 NF2F consultations: 1035 kg of CO<sub>2</sub> equivalent (on 5676.16 km traveled)</td>
              </tr>
              <tr valign="top">
                <td>Roy et al [<xref ref-type="bibr" rid="ref103">103</xref>], United States, 2023</td>
                <td>University hospital (gastroenterology)</td>
                <td>Evaluating the environmental impact of NF2F versus F2F visits</td>
                <td>Telemedicine (T and VC)</td>
                <td>Travel-related emissions</td>
                <td>Google Maps</td>
                <td>None</td>
                <td>NA</td>
                <td>Carbon emissions (CO<sub>2</sub>)</td>
                <td>Avoided emissions per NF2F consultation: 31.5 kg of CO<sub>2</sub> equivalent (average of 126.61 km traveled); avoided emissions in total for 111 NF2F consultations: 3175.15 kg of CO<sub>2</sub> equivalent (14,038.31 km traveled)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Data: Assumptions and data used for nondigital calculations.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>Factors: Methodological assumptions and factors per technology.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>LCA: life cycle analysis.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>Outcome: Measured environmental income</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>NF2F: non–face-to-face.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>F2F: face-to-face.</p>
            </fn>
            <fn id="table1fn7">
              <p><sup>g</sup>T: telephone.</p>
            </fn>
            <fn id="table1fn8">
              <p><sup>h</sup>DEFRA: Department for Environment, Food, and Rural Affairs.</p>
            </fn>
            <fn id="table1fn9">
              <p><sup>i</sup>NHS: National Health Service.</p>
            </fn>
            <fn id="table1fn10">
              <p><sup>j</sup>NA: not assessed.</p>
            </fn>
            <fn id="table1fn11">
              <p><sup>k</sup>CO<sub>2</sub>: carbon dioxide.</p>
            </fn>
            <fn id="table1fn12">
              <p><sup>l</sup>OSA: obstructive sleep apnea.</p>
            </fn>
            <fn id="table1fn13">
              <p><sup>m</sup>OM: otitis media.</p>
            </fn>
            <fn id="table1fn14">
              <p><sup>n</sup>VC: videoconference.</p>
            </fn>
            <fn id="table1fn15">
              <p><sup>o</sup>GHG: greenhouse gas.</p>
            </fn>
            <fn id="table1fn16">
              <p><sup>p</sup>EEC: embodied energy consumption.</p>
            </fn>
            <fn id="table1fn17">
              <p><sup>q</sup>OEC: operational energy consumption.</p>
            </fn>
            <fn id="table1fn18">
              <p><sup>r</sup>D: device.</p>
            </fn>
            <fn id="table1fn19">
              <p><sup>s</sup>DT: data transmission.</p>
            </fn>
            <fn id="table1fn20">
              <p><sup>t</sup>SR: system resources.</p>
            </fn>
            <fn id="table1fn21">
              <p><sup>u</sup>NS: not specified.</p>
            </fn>
            <fn id="table1fn22">
              <p><sup>v</sup>NIHR: National Institute for Health and Care Research.</p>
            </fn>
            <fn id="table1fn23">
              <p><sup>w</sup>ISO: International Organization for Standardization.</p>
            </fn>
            <fn id="table1fn24">
              <p><sup>x</sup>EPA: Environmental Protection Agency.</p>
            </fn>
            <fn id="table1fn25">
              <p><sup>y</sup>IEA: International Energy Agency.</p>
            </fn>
            <fn id="table1fn26">
              <p><sup>z</sup>LCI: life cycle inventory.</p>
            </fn>
            <fn id="table1fn27">
              <p><sup>aa</sup>EHR: electronic health record.</p>
            </fn>
            <fn id="table1fn28">
              <p><sup>ab</sup>TREMOD: Transport Emission Model.</p>
            </fn>
            <fn id="table1fn29">
              <p><sup>ac</sup>UBA: German Federal Environment Agency.</p>
            </fn>
            <fn id="table1fn30">
              <p><sup>ad</sup>UN: United Nations.</p>
            </fn>
            <fn id="table1fn31">
              <p><sup>ae</sup>ICAO: International Civil Aviation Organization.</p>
            </fn>
            <fn id="table1fn32">
              <p><sup>af</sup>SPML: selective percutaneous myofascial lengthening.</p>
            </fn>
            <fn id="table1fn33">
              <p><sup>ag</sup>BEIS: Department for Business, Energy, and Industrial Strategy.</p>
            </fn>
            <fn id="table1fn34">
              <p><sup>ah</sup>FHWA: Federal Highway Administration.</p>
            </fn>
            <fn id="table1fn35">
              <p><sup>ai</sup>PM10: particulate matter≤10μm.</p>
            </fn>
            <fn id="table1fn36">
              <p><sup>aj</sup>PM2.5: particulate matter≤2.5μm.</p>
            </fn>
            <fn id="table1fn37">
              <p><sup>ak</sup>eWCC: Virtual Wound Care Command Centre.</p>
            </fn>
            <fn id="table1fn38">
              <p><sup>al</sup>GNAF: Geocoded National Address File.</p>
            </fn>
            <fn id="table1fn39">
              <p><sup>am</sup>SEAI: Sustainable Energy Authority of Ireland.</p>
            </fn>
            <fn id="table1fn40">
              <p><sup>an</sup>PSSRU: Personal Social Services Research Unit.</p>
            </fn>
            <fn id="table1fn41">
              <p><sup>ao</sup>AI: artificial intelligence.</p>
            </fn>
            <fn id="table1fn42">
              <p><sup>ap</sup>DfT: UK Department for Transport.</p>
            </fn>
            <fn id="table1fn43">
              <p><sup>aq</sup>PROC: Peninsula Radiology On-Call.</p>
            </fn>
            <fn id="table1fn44">
              <p><sup>ar</sup>DECC: Department of Energy and Climate Change.</p>
            </fn>
            <fn id="table1fn45">
              <p><sup>as</sup>BITRE: Bureau of Infrastructure and Transport Research Economics.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>The publication date of the studies included ranged between 2009 and 2024, with a notable increase in the number of publications per year, particularly from 2020 to 2023 (<xref rid="figure2" ref-type="fig">Figure 2</xref>). When considering the entire period, this trend is evident as nearly three-quarters (43/58, 74%) of the studies were published during these years [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>-<xref ref-type="bibr" rid="ref77">77</xref>, <xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref91">91</xref>,<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref100">100</xref>,<xref ref-type="bibr" rid="ref103">103</xref>].</p>
        <p>Most of the studies (34/58, 59%) were conducted either in the United States (21/24, 88%; <xref ref-type="table" rid="table1">Table 1</xref>) or in the United Kingdom (13/24, 54%; <xref ref-type="table" rid="table1">Table 1</xref>). Other studies were conducted in Australia (3/58, 5%) [<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref101">101</xref>], Canada (3/58, 5%) [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>], Scotland (3/58, 5%) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref90">90</xref>], Spain (3/58, 5%) [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref80">80</xref>], Germany (2/58, 3%) [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], Sweden (2/58, 3%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref49">49</xref>], and Ireland (2/58, 3%) [<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref98">98</xref>]. Studies were also conducted in Wales (1/58, 2%) [<xref ref-type="bibr" rid="ref60">60</xref>], Portugal (1/58, 2%) [<xref ref-type="bibr" rid="ref99">99</xref>], Oman (1/58, 2%), Italy (1/58, 2%) [<xref ref-type="bibr" rid="ref50">50</xref>], Denmark (1/58, 2%) [<xref ref-type="bibr" rid="ref74">74</xref>], and Switzerland (1/58, 2%) [<xref ref-type="bibr" rid="ref75">75</xref>].</p>
        <p>Examining the settings of the studies, it is evident that more than two-thirds (41/58, 71%) were conducted in hospital environments, including general hospitals (26/58, 45%; <xref ref-type="table" rid="table1">Table 1</xref>) and university hospitals (15/58, 26%; <xref ref-type="table" rid="table1">Table 1</xref>). A smaller number of studies focused on the broader health care system either at the regional (2/58, 3%) [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref90">90</xref>] or national (6/58, 10%) level [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], encompassing a range of health care settings. Only 2% (1/58) of the studies were conducted in the context of primary health care [<xref ref-type="bibr" rid="ref54">54</xref>]. <xref rid="figure3" ref-type="fig">Figure 3</xref> shows the number of studies by country and setting for further information.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Number of studies by year of publication.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e71795_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>Number of studies by country and study setting. UK: United Kingdom; USA: United States.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e71795_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Environmental Assessment of Digital Health Technologies</title>
        <p>The digital technology most frequently analyzed (<xref ref-type="table" rid="table2">Table 2</xref>) in terms of environmental sustainability was telemedicine (53/58, 91%). Of these studies, most (33/58, 57%; <xref ref-type="table" rid="table1">Table 1</xref>) focused on the videoconferencing format, whereas only 10% (6/58) of the studies examined telephony [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref100">100</xref>,<xref ref-type="bibr" rid="ref103">103</xref>] and 5% (3/58) of the studies included both formats. A total of 19% (11/58) of the studies investigating telemedicine did not specify the form of telemedicine analyzed (<xref ref-type="table" rid="table1">Table 1</xref>). Other digital technologies examined, each in a single study, included AI [<xref ref-type="bibr" rid="ref10">10</xref>], a digital application [<xref ref-type="bibr" rid="ref77">77</xref>], a web platform [<xref ref-type="bibr" rid="ref79">79</xref>], and remote working in radiology [<xref ref-type="bibr" rid="ref95">95</xref>].</p>
        <p>An analysis of the methods used to assess the environmental impact of digital technologies reveals that, regardless of the specific technology examined, nearly all studies (56/58, 97%; <xref ref-type="table" rid="table1">Table 1</xref>) quantified the transport-related emissions that were avoided through digitalization. A subset of studies (5/58, 9%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref96">96</xref>] additionally calculated the emissions avoided from reduced building operations in health care facilities considering factors such as heating, ventilation, air conditioning, lighting, and waste. Furthermore, 5% (3/58) of the studies [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] included emissions generated by medical equipment such as personal protective equipment, hand sanitizer, and durable medical examination devices. Lathan et al [<xref ref-type="bibr" rid="ref86">86</xref>] additionally included emissions produced by pharmaceuticals. Wolf et al [<xref ref-type="bibr" rid="ref10">10</xref>] investigated the greenhouse gas emissions caused by an ophthalmologic examination conducted by an ophthalmologist compared to an examination conducted using AI.</p>
        <p>Only 28% (16/58) of the studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref96">96</xref>] compared the energy consumption and associated emissions of the examined digital technologies. All these studies (16/16, 100%) included the energy consumption generated by the use of digital technologies, meaning the operational energy. A wide range of factors were considered in these calculations. The most frequently included factor was end-user devices (8/16, 50%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref91">91</xref>], followed by data transmission (6/16, 38%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref91">91</xref>] and system resource use (5/16, 31%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], such as network or server use.</p>
        <p>Energy consumption data were sourced from government institutions in 8 studies, including the US Environmental Protection Agency (n=3, 38%) [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]; the German Federal Environment Agency (n=2, 25%) [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]; the UK Department for Environment, Food, and Rural Affairs and Department for Business, Energy, and Industrial Strategy (n=2, 25%) [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref91">91</xref>]; and the Government of British Columbia (n=1, 12%) [<xref ref-type="bibr" rid="ref44">44</xref>]. Only Schmitz-Grosz et al [<xref ref-type="bibr" rid="ref75">75</xref>] included emissions from building premises alongside energy consumption in their analysis.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Number of studies by digital technology assessed.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="600"/>
            <col width="400"/>
            <thead>
              <tr valign="top">
                <td>Digital technology assessed</td>
                <td>Studies (n=58), n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Remote working</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Digital application</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Web platform</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Artificial intelligence</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Electronic health record</td>
                <td>2 (3)</td>
              </tr>
              <tr valign="top">
                <td>Telemedicine</td>
                <td>53 (91)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>Nearly half (7/16, 44%) of the studies that compared the energy consumption and associated emissions of the examined digital technologies (<xref ref-type="table" rid="table1">Table 1</xref>) used LCA to quantify emissions generated throughout the life cycle of digital technologies from production to disposal. This represents 12% (7/58) of the total number of studies. The LCA methodology proposed by Ong et al [<xref ref-type="bibr" rid="ref46">46</xref>] was the most frequently used (3/7, 43%) [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref96">96</xref>]. Other frameworks used included the International Organization for Standardization 14040/14044 standard (1/7, 14%) [<xref ref-type="bibr" rid="ref55">55</xref>], the ecoinvent version 3.8 database (1/7, 14%) [<xref ref-type="bibr" rid="ref50">50</xref>], and the EcoHealth Footprint framework (1/7, 14%) [<xref ref-type="bibr" rid="ref81">81</xref>], each applied in a different individual study.</p>
      </sec>
      <sec>
        <title>Reported Outcomes: Environmental, Social, and Economic Impacts</title>
        <p>Most studies (47/58, 81%) expressed the environmental impact of digital technologies in terms of avoided CO<sub>2</sub> emissions. Additional studies (10/58, 17%; <xref ref-type="table" rid="table1">Table 1</xref>) reported on various greenhouse gas emissions, such as carbon monoxide, nitrogen oxides, and methane. Only Turley et al [<xref ref-type="bibr" rid="ref81">81</xref>] provided insights beyond avoiding greenhouse gas emissions and discussed the reductions in waste, toxic chemicals, water use, and air pollution resulting from digitalization. However, these calculations were conducted solely for the traditional form of x-ray imaging, not for the digital variant [<xref ref-type="bibr" rid="ref81">81</xref>].</p>
        <p>The CO<sub>2</sub> emissions avoided using telemedicine ranged from 0.57 kg [<xref ref-type="bibr" rid="ref75">75</xref>] to 499.84 kg [<xref ref-type="bibr" rid="ref62">62</xref>] per consultation. For studies that did not report specific data on the avoided emissions per consultation, these were calculated based on the total emissions and the number of consultations. The arithmetic mean of these values was calculated as medians with SDs were not possible to calculate due to the lack of individual values. The calculations were conducted using Microsoft Excel (version 16.95.1). A positive correlation was identified between the amount of emissions avoided and the distance saved by avoiding travel to health care facilities. In total, 830,118,137 kg of CO<sub>2</sub> were avoided across all telemedicine studies. However, it was not possible to determine the total emissions avoided in 12% (7/58) of the studies [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref96">96</xref>]. Barakat-Johnson et al [<xref ref-type="bibr" rid="ref77">77</xref>] reported a CO<sub>2</sub> reduction of 250 kg for 51 users of the Virtual Wound Care Command Centre app. Similarly, Peters et al [<xref ref-type="bibr" rid="ref95">95</xref>] demonstrated that remote work can reduce CO<sub>2</sub> emissions by up to 4300 kg. The use of the MyPreOp web platform by 813 patients, as analyzed by Milne-Ives et al [<xref ref-type="bibr" rid="ref79">79</xref>], resulted in CO<sub>2</sub> savings of 9050 kg over a 4-month period. Wolf et al [<xref ref-type="bibr" rid="ref10">10</xref>] estimated CO<sub>2</sub> emissions of 0.02 to 0.2 g for eye examinations conducted using AI technology in contrast to the approximately 8 kg emitted during a traditional ophthalmological examination.</p>
        <p>In nearly two-thirds of the studies reviewed (36/58, 62%), social outcomes were also considered in addition to ecological effects (<xref ref-type="table" rid="table3">Table 3</xref>). Key social end points included patient satisfaction (16/58, 28%; <xref ref-type="table" rid="table3">Table 3</xref>) and overall patient experience (6/58, 10%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref102">102</xref>], with additional attention paid to patient safety (2/58, 3%) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref91">91</xref>] and health outcomes (9/58, 16%; <xref ref-type="table" rid="table3">Table 3</xref>). In total, 3% (2/58) of the studies [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>] evaluated the general feasibility of telemedicine across various fields. Another frequently examined end point was the time savings associated with the use of digital technologies (9/58, 16%; <xref ref-type="table" rid="table3">Table 3</xref>). Only 3% (2/58) of the studies [<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref100">100</xref>] incorporated the perspective of health care staff. Additional factors examined included quality-adjusted life years (1/58, 2%) [<xref ref-type="bibr" rid="ref47">47</xref>], the associations between telehealth use and demographic variables (1/58, 2%) [<xref ref-type="bibr" rid="ref63">63</xref>], and the impact of telehealth use on low-income families (1/58, 2%) [<xref ref-type="bibr" rid="ref67">67</xref>].</p>
        <p>Economic factors were explored in 48% (28/58) of the studies (<xref ref-type="table" rid="table3">Table 3</xref>). These investigations encompassed the reduction in travel costs for patients (24/58, 41%; <xref ref-type="table" rid="table3">Table 3</xref>), loss of income due to attending in-person appointments (6/58, 10%) [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref100">100</xref>], and financial savings for health care providers (10/58, 17%; <xref ref-type="table" rid="table3">Table 3</xref>).</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Studies that assessed social and economic impacts.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="310"/>
            <col width="320"/>
            <col width="370"/>
            <thead>
              <tr valign="top">
                <td>Study, country, year</td>
                <td>Economic impact</td>
                <td>Social impact</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Curtis et al [<xref ref-type="bibr" rid="ref43">43</xref>], United Kingdom, 2021</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient preference and patient experience</td>
              </tr>
              <tr valign="top">
                <td>Heffernan et al [<xref ref-type="bibr" rid="ref44">44</xref>], Canada, 2023</td>
                <td>No</td>
                <td>Yes—patient safety</td>
              </tr>
              <tr valign="top">
                <td>Holmner et al [<xref ref-type="bibr" rid="ref19">19</xref>], Sweden, 2014</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Smith et al [<xref ref-type="bibr" rid="ref47">47</xref>], United Kingdom, 2013</td>
                <td>Yes—financial costs (health care system)</td>
                <td>Yes—QALYs<sup>a</sup></td>
              </tr>
              <tr valign="top">
                <td>Connor et al [<xref ref-type="bibr" rid="ref48">48</xref>], United Kingdom, 2011</td>
                <td>Yes—financial costs (health care system)</td>
                <td>Yes—patient safety</td>
              </tr>
              <tr valign="top">
                <td>Kassa et al [<xref ref-type="bibr" rid="ref49">49</xref>], Sweden, 2024</td>
                <td>No</td>
                <td>Yes—patient satisfaction and patient experience</td>
              </tr>
              <tr valign="top">
                <td>Savoldelli et al [<xref ref-type="bibr" rid="ref50">50</xref>], Italy, 2024</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Tselapedi-Sekeitto et al [<xref ref-type="bibr" rid="ref52">52</xref>], Canada, 2024</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Welk et al [<xref ref-type="bibr" rid="ref53">53</xref>], Canada, 2022</td>
                <td>Yes—travel costs (patient)</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Dorrian et al [<xref ref-type="bibr" rid="ref54">54</xref>], Scotland, 2009</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>Yes—patient satisfaction and patient safety</td>
              </tr>
              <tr valign="top">
                <td>Thiel et al [<xref ref-type="bibr" rid="ref55">55</xref>], United States, 2023</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Morcillo Serra et al [<xref ref-type="bibr" rid="ref56">56</xref>], Spain, 2022</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Jiang et al [<xref ref-type="bibr" rid="ref57">57</xref>], United States, 2021</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Cummins et al [<xref ref-type="bibr" rid="ref58">58</xref>], United States, 2024</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Grabski et al [<xref ref-type="bibr" rid="ref59">59</xref>], United States, 2024</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Lewis et al [<xref ref-type="bibr" rid="ref60">60</xref>], Wales, 2009</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—time savings</td>
              </tr>
              <tr valign="top">
                <td>Evers et al [<xref ref-type="bibr" rid="ref61">61</xref>], United States, 2021</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient experience and patient preference</td>
              </tr>
              <tr valign="top">
                <td>Arndt et al [<xref ref-type="bibr" rid="ref62">62</xref>], Germany, 2023</td>
                <td>No</td>
                <td>Yes—patient satisfaction, time savings, and feasibility</td>
              </tr>
              <tr valign="top">
                <td>Cockrell et al [<xref ref-type="bibr" rid="ref63">63</xref>], United States, 2022</td>
                <td>No</td>
                <td>Yes—association between demographics and telehealth use</td>
              </tr>
              <tr valign="top">
                <td>Sellars et al [<xref ref-type="bibr" rid="ref64">64</xref>], Scotland, 2020</td>
                <td>Yes—travel costs (patient) and financial costs (health care system)</td>
                <td>Yes—feasibility</td>
              </tr>
              <tr valign="top">
                <td>Al Fannah et al [<xref ref-type="bibr" rid="ref65">65</xref>], Oman, 2022</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Robinson et al [<xref ref-type="bibr" rid="ref67">67</xref>], United States, 2017</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>Yes—time savings, caregiver burden, and impact on low-income families</td>
              </tr>
              <tr valign="top">
                <td>Chang et al [<xref ref-type="bibr" rid="ref68">68</xref>], United States, 2023</td>
                <td>Yes—travel costs (patient)</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Muschol et al [<xref ref-type="bibr" rid="ref69">69</xref>], Germany, 2022</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Vidal-Alaball [<xref ref-type="bibr" rid="ref70">70</xref>], Spain, 2019</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—time savings</td>
              </tr>
              <tr valign="top">
                <td>King et al [<xref ref-type="bibr" rid="ref71">71</xref>], United Kingdom, 2022</td>
                <td>No</td>
                <td>Yes—health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Lee et al [<xref ref-type="bibr" rid="ref72">72</xref>], United States, 2021</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Patel et al [<xref ref-type="bibr" rid="ref73">73</xref>], United States, 2023</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Dieperink et al [<xref ref-type="bibr" rid="ref74">74</xref>], Denmark, 2023</td>
                <td>No</td>
                <td>Yes—time savings, patient experience, and nurse experience</td>
              </tr>
              <tr valign="top">
                <td>Schmitz-Grosz et al [<xref ref-type="bibr" rid="ref75">75</xref>], Germany and Switzerland, 2023</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Iaccarino et al [<xref ref-type="bibr" rid="ref76">76</xref>], United States, 2022</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Barakat-Johnson et al [<xref ref-type="bibr" rid="ref77">77</xref>], Australia, 2022</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient satisfaction and health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Connor et al [<xref ref-type="bibr" rid="ref78">78</xref>], United Kingdom, 2019</td>
                <td>Yes—financial costs (health care system)</td>
                <td>Yes—health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Milne-Ives et al [<xref ref-type="bibr" rid="ref79">79</xref>], United Kingdom, 2022</td>
                <td>No</td>
                <td>Yes—patient satisfaction and time savings</td>
              </tr>
              <tr valign="top">
                <td>Moncho-Santonja et al [<xref ref-type="bibr" rid="ref80">80</xref>], Spain, 2023</td>
                <td>Yes—travel costs (patient)</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Turley et al [<xref ref-type="bibr" rid="ref81">81</xref>], United States, 2011</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Andrew et al [<xref ref-type="bibr" rid="ref82">82</xref>], Australia, 2020</td>
                <td>No</td>
                <td>Yes—patient experience</td>
              </tr>
              <tr valign="top">
                <td>Dullet et al [<xref ref-type="bibr" rid="ref83">83</xref>], United States, 2017</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Carr and Kevitt [<xref ref-type="bibr" rid="ref84">84</xref>], Ireland, 2023</td>
                <td>No</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Bove et al [<xref ref-type="bibr" rid="ref85">85</xref>], United States, 2023</td>
                <td>Yes—travel costs (patient) and financial costs (health care system)</td>
                <td>Yes—health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Lathan et al [<xref ref-type="bibr" rid="ref86">86</xref>], United Kingdom, 2024</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Wolf et al [<xref ref-type="bibr" rid="ref10">10</xref>], United States, 2022</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Mojdehbakhsh et al [<xref ref-type="bibr" rid="ref87">87</xref>], United States, 2021</td>
                <td>No</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Sillcox et al [<xref ref-type="bibr" rid="ref51">51</xref>], United States, 2023</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Sillcox et al [<xref ref-type="bibr" rid="ref88">88</xref>], United States, 2023</td>
                <td>No</td>
                <td>Yes—health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Thota et al [<xref ref-type="bibr" rid="ref89">89</xref>], United States, 2020</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>Yes—time savings</td>
              </tr>
              <tr valign="top">
                <td>Wootton et al [<xref ref-type="bibr" rid="ref90">90</xref>], Scotland, 2010</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Blenkinsop et al [<xref ref-type="bibr" rid="ref91">91</xref>], United Kingdom, 2021</td>
                <td>Yes—travel costs (patient) and financial costs (health care system)</td>
                <td>Yes—patient safety</td>
              </tr>
              <tr valign="top">
                <td>Miah et al [<xref ref-type="bibr" rid="ref93">93</xref>], United Kingdom, 2019</td>
                <td>Yes—financial costs (health care system)</td>
                <td>Yes—patient satisfaction</td>
              </tr>
              <tr valign="top">
                <td>Paquette and Lin [<xref ref-type="bibr" rid="ref94">94</xref>], United States, 2019</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—time savings</td>
              </tr>
              <tr valign="top">
                <td>Peters et al [<xref ref-type="bibr" rid="ref95">95</xref>], United Kingdom, 2020</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Bartlett and Keir [<xref ref-type="bibr" rid="ref96">96</xref>], United Kingdom, 2022</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Croghan et al [<xref ref-type="bibr" rid="ref98">98</xref>], Ireland, 2021</td>
                <td>Yes—travel costs (patient)</td>
                <td>Yes—health outcomes and time savings</td>
              </tr>
              <tr valign="top">
                <td>Oliveira et al [<xref ref-type="bibr" rid="ref99">99</xref>], Portugal, 2013</td>
                <td>No</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Gupta et al [<xref ref-type="bibr" rid="ref100">100</xref>], United Kingdom, 2023</td>
                <td>Yes—travel costs (patient) and lost wages</td>
                <td>Yes—health outcomes, patient satisfaction, and nurse experience</td>
              </tr>
              <tr valign="top">
                <td>Schulz et al [<xref ref-type="bibr" rid="ref101">101</xref>], Australia, 2020</td>
                <td>Yes—travel costs (patient) and financial costs (health care system)</td>
                <td>Yes—patient satisfaction and health outcomes</td>
              </tr>
              <tr valign="top">
                <td>Udayaraj et al [<xref ref-type="bibr" rid="ref102">102</xref>], United Kingdom, 2019</td>
                <td>Yes—financial costs (health care system)</td>
                <td>Yes—health outcomes, patient satisfaction, and patient experience</td>
              </tr>
              <tr valign="top">
                <td>Roy et al [<xref ref-type="bibr" rid="ref103">103</xref>], United States, 2023</td>
                <td>No</td>
                <td>Yes—patient satisfaction</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>QALY: quality-adjusted life year.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>The Digitalization of Health Care: More Than Just Telemedicine?</title>
        <p>An analysis of the results related to the RQs reveals that the ecological benefits of digitalization in health care are predominantly studied in the context of telemedicine. Rodler et al [<xref ref-type="bibr" rid="ref18">18</xref>] recently demonstrated, across 48 systematically analyzed studies, that telemedicine is associated with reduced CO<sub>2</sub> emissions and contributes to lowering the health care sector’s carbon footprint. Similarly, in their review, Purohit et al [<xref ref-type="bibr" rid="ref104">104</xref>] identified a wide variance in CO<sub>2</sub> emissions, ranging from 0.70 to 372 kg per consultation. They found that the reduction in CO<sub>2</sub> emissions resulting from the avoidance of in-person visits was primarily linked to a decrease in travel distance to health care facilities. To explain the considerable variance in these study results, a comparison between the studies by Purohit et al [<xref ref-type="bibr" rid="ref104">104</xref>] and Rodler et al [<xref ref-type="bibr" rid="ref18">18</xref>] also reveals that this variance was partly attributable to the underlying modeling approaches used for calculating CO<sub>2</sub> emissions, as well as the technologies used and the degree of specialization of the facilities [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref104">104</xref>]. According to Rodler et al [<xref ref-type="bibr" rid="ref18">18</xref>], factors that may play a role in the modeling include not only the consideration of emissions from the technologies used but also the underlying data used for the calculations as these are often based on assumptions and estimates rather than precise measurements. Furthermore, it is clear that data collection and evaluations of AI, electronic health records, and other digital applications in health care have only been conducted to a limited extent.</p>
        <p>If we examine the publications in the field of AI, it becomes evident that it can contribute in many different ways to overcoming problems in the health care sector. In addition to assisting with environmental medical challenges such as predicting outbreaks of infectious diseases or real-time analysis of environmental data on air quality [<xref ref-type="bibr" rid="ref16">16</xref>], AI can also help optimize energy consumption [<xref ref-type="bibr" rid="ref14">14</xref>]. However, it quickly becomes apparent that research into the environmental impacts associated with the use of AI in health care is scarce. In this review, only 2% (1/58) of the studies examined the carbon footprint of AI [<xref ref-type="bibr" rid="ref10">10</xref>]. Other studies examining the sustainability of AI generally rely on data concerning its use in broader contexts, such as industry or general applications [<xref ref-type="bibr" rid="ref105">105</xref>]. Although these studies provide an important initial step in highlighting the potential for AI to promote greater sustainability in health care, they fail to fully address the specific environmental impacts of AI within the health care sector [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. A similar gap exists in the literature regarding the use of digital patient records. Beyond a few studies documenting reductions in energy consumption [<xref ref-type="bibr" rid="ref106">106</xref>], detailed investigations are lacking, with only 2 comprehensive studies included in this review [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. In addition, only 1 digital health application has been analyzed with respect to its ecological impact [<xref ref-type="bibr" rid="ref77">77</xref>], further underscoring the significant research deficit in evaluating the environmental consequences of digital health care technologies other than telemedicine.</p>
        <p>The question arises of how such a significant research gap regarding the sustainability of other digital health technologies has emerged. When examining the studies by their publication date, it becomes apparent that, during the COVID-19 pandemic (2020-2023), there was an increase in publications in the telemedicine field as there was a heightened demand for web-based services [<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]. Furthermore, telemedicine is one of the longest-established digital technologies, making it likely that it has been studied more frequently. In addition to these aspects, it must also be considered that telemedicine provides very concrete metrics, such as travel distance and mode of transport, which can be used to calculate avoided CO<sub>2</sub> emissions [<xref ref-type="bibr" rid="ref74">74</xref>]. Calculating CO<sub>2</sub> emissions and other environmental impacts of other digital technologies is more challenging due to the complexity of the digital infrastructure. Factors such as the withholding of data by individual companies in the supply chains of digital devices, which complicates comprehensive calculations for hardware and software; the lack of standardization in CO<sub>2</sub> emission calculation and modeling methods for digital technologies; and the use of different energy sources all play a role in this complexity [<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref107">107</xref>].</p>
        <p>To comprehensively assess how digitalization in health care impacts the ecological goals of the Planetary Health movement, further studies that extend beyond the evaluation of telemedicine are needed. Data collection for digital technologies such as AI and electronic health records should be conducted specifically within the context of health care. This is essential for a holistic assessment of the environmental effects of these technologies.</p>
      </sec>
      <sec>
        <title>Clean Digital Health?</title>
        <p>While the environmental impact of digitalization is most often evaluated through the perspective of CO<sub>2</sub> emissions, such assessments often overlook other significant factors, including the generation of electronic waste and its associated consequences, as well as the extraction and consumption of natural resources [<xref ref-type="bibr" rid="ref108">108</xref>,<xref ref-type="bibr" rid="ref109">109</xref>]. Only 2% (1/58) of the studies in this review, using the EcoHealth Footprint framework, provided a more comprehensive understanding of the environmental impacts of digitalization [<xref ref-type="bibr" rid="ref81">81</xref>]. Relying solely on CO<sub>2</sub> emissions as an indicator of environmental sustainability provides an incomplete picture of the true ecological impact of digitalization. Therefore, it is imperative that future research adopts more comprehensive assessment approaches that incorporate a broader range of environmental factors to ensure meaningful and informed evaluations [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. Moyano-Fernández et al [<xref ref-type="bibr" rid="ref108">108</xref>], along with Thompson [<xref ref-type="bibr" rid="ref25">25</xref>] and Vandemeulebroucke [<xref ref-type="bibr" rid="ref110">110</xref>], emphasize the importance of considering the long-term ecological effects of AI and other digital technologies to determine what constitutes sustainable digitalization. Therefore, it is essential to explore how additional environmental effects can be identified and incorporated into ecological assessments [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. One proposed approach for achieving a more holistic and long-term perspective on digitalization is through LCA [<xref ref-type="bibr" rid="ref38">38</xref>]. However, given that only 12% (7/58) of the studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref96">96</xref>] used LCAs in their assessments, a clear discrepancy emerges between the recognized need for long-term evaluation of digitalization and the LCAs that have actually been conducted. In their review, Lokmic-Tomkins et al [<xref ref-type="bibr" rid="ref38">38</xref>] examined assessment tools for digital technologies and similarly concluded that no standardized procedure exists for assessing the ecological impact of digital technologies in the health care sector. This highlights the necessity for more consistent and comprehensive approaches to environmental evaluation in this field.</p>
      </sec>
      <sec>
        <title>Planetary Health as a Framework</title>
        <p>Previous research has emphasized the need for uniform and stringent framework conditions and guidelines. Bevere and Faccilongo [<xref ref-type="bibr" rid="ref111">111</xref>] conducted a comprehensive analysis of the application of digital technologies in the health care sector to enhance energy efficiency across various domains. They concluded that there is a pressing need for government initiatives to prioritize energy efficiency and environmental sustainability. In addition to providing tax incentives for environmentally friendly technologies, these initiatives should also incorporate employee training [<xref ref-type="bibr" rid="ref111">111</xref>].</p>
        <p>The establishment of such structures and frameworks at both national and international levels using diverse strategic approaches is deemed essential [<xref ref-type="bibr" rid="ref12">12</xref>]. Rahimi-Ardabili et al [<xref ref-type="bibr" rid="ref13">13</xref>] raised concerns regarding the evaluation and assessment of existing tools, particularly in terms of their validity for decision-making at multiple levels concerning sustainability in health care. Furthermore, there is a notable lack of awareness among decision makers regarding established green IT frameworks, leading to the underuse of existing systems [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>Samuel and Lucassen [<xref ref-type="bibr" rid="ref109">109</xref>], building on the work by Lannelongue et al [<xref ref-type="bibr" rid="ref112">112</xref>], developed initial approaches and formulated 10 principles for ecologically sustainable IT practices in the health care sector. These principles not only emphasize the need for documenting CO<sub>2</sub> emissions associated with IT systems but also advocate for the prolonged use of devices and the judicious selection of equipment with regard to ecological sustainability [<xref ref-type="bibr" rid="ref109">109</xref>]. Ueda et al [<xref ref-type="bibr" rid="ref14">14</xref>] proposed action principles for the sustainable use and ecological consideration of AI. Their findings suggest that, in addition to the application of LCA, efforts toward green computing, the development of energy-efficient AI models, and factors such as education and integration into broader sustainability initiatives are equally important [<xref ref-type="bibr" rid="ref14">14</xref>]. Sittig et al [<xref ref-type="bibr" rid="ref113">113</xref>] introduced the IT-Enabled Clinical Climate Informatics Actions for the Environment framework, which presents further approaches to creating sustainable conditions, including promoting a circular economy, reducing energy consumption, supporting administrators in decision-making, mobilizing the workforce, and informing employees about policies and regulations to drive change. Sijm-Eeken et al [<xref ref-type="bibr" rid="ref114">114</xref>] also developed a framework that combined medical informatics solutions with their environmental impacts. The <italic>Green Mission framework</italic> incorporates IT solution architecture (enhanced by governance), climate resilience, and environmental impacts [<xref ref-type="bibr" rid="ref114">114</xref>].</p>
        <p>On the basis of a first cursory comparison of these different frameworks for sustainable digitalization, the following factors should be considered when implementing such a guideline [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref109">109</xref>,<xref ref-type="bibr" rid="ref113">113</xref>,<xref ref-type="bibr" rid="ref114">114</xref>]: (1) long-term perspective regarding the sustainability of deployed technologies, (2) interoperability of digital systems, (3) stakeholder engagement and cooperation among various actors in health care, (4) sociotechnical dimensions for integrating digital technologies into daily work routines, (5) sustainability as a multidimensional concept, (6) data protection and security, and (7) improving health care delivery through the use of digital technologies.</p>
        <p>Despite the consideration of numerous factors, it remains apparent that there are still several gaps regarding technical feasibility, social inclusion, and evaluative measures.</p>
        <p>A comprehensive analysis of these frameworks with regard to their practical applicability, existing gaps, and long-term effectiveness could contribute to the development of a more integrated and holistic concept for sustainable digitalization within the health care sector [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref115">115</xref>].</p>
        <p>The findings related to social and economic aspects reflect the core principles of the Planetary Health concept, aiming to integrate sustainability, social benefits, and economic considerations within a holistic framework [<xref ref-type="bibr" rid="ref115">115</xref>]. For example, digital health solutions that reduce travel-related emissions may also improve patient convenience and access—especially for marginalized populations—while alleviating pressure on health care infrastructure. However, the limited inclusion of health care staff perspectives (only 2/58, 3% of the studies) and sparse attention to economic metrics such as quality-adjusted life years (1/58, 2% of the studies) suggest an underexplored opportunity to further integrate all 3 dimensions of sustainability in future research [<xref ref-type="bibr" rid="ref116">116</xref>,<xref ref-type="bibr" rid="ref117">117</xref>].</p>
        <p>It is evident that the implementation of ecologically sustainable digitalization is highly complex and requires consideration of a wide range of factors aligned with the goals of sustainable health, as advocated by the Planetary Health movement [<xref ref-type="bibr" rid="ref109">109</xref>,<xref ref-type="bibr" rid="ref114">114</xref>]. However, a standardized assessment framework or set of guidelines for achieving sustainable digitalization in the health care sector has yet to be identified [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
        <p>Recently, Ip [<xref ref-type="bibr" rid="ref118">118</xref>] outlined the social ambivalence of digitalization in relation to the goals of the Planetary Health movement in a commentary published in <italic>The Lancet</italic>. The ethical guidelines derived from this discussion emphasize, first, the need for equitable access to digitalization, the preservation of natural ecosystems, and the significant responsibility placed on professionals to engage in sustainable practices [<xref ref-type="bibr" rid="ref118">118</xref>].</p>
        <p>Building on this, the ecological ambivalence of digitalization, as outlined previously, underscores the necessity for guidelines that promote ecologically sustainable digitalization in the health care sector [<xref ref-type="bibr" rid="ref25">25</xref>]. Given that the Planetary Health movement not only addresses ecological sustainability but also integrates human health and social issues, thereby offering a broader conception of sustainability, it serves as an ideal foundation for developing a comprehensive set of guidelines.</p>
        <p>Thus, Planetary Health can provide the guiding framework for the creation of appropriate directives for sustainable digital transformation in health care.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>Potential limitations of this study include the risk of bias due to the involvement of a single reviewer (single-reviewer bias). As the primary selection and evaluation of studies were conducted by a single reviewer, there is a possibility that personal biases, individual experiences, or methodological preferences impacted the objectivity of the results [<xref ref-type="bibr" rid="ref119">119</xref>]. To mitigate this, eligible and critical studies were discussed in collaboration with a second reviewer. However, to further address this limitation, future research should involve multiple independent reviewers to ensure a more balanced and robust interpretation of the data. Another limitation arises from the absence of a systematic assessment of study quality. In addition, some full-text articles were inaccessible or excluded due to language barriers, potentially leading to the exclusion of relevant publications from this review.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>There have already been efforts to make the increasing digitalization of the health care sector ecologically sustainable, and certain digital technologies have demonstrated ecologically sustainable effects. However, a clear discrepancy exists between the available studies assessing the ecological impact of digitalization in health care and the growing demand for ecological guidelines. This is evident in the lack of comprehensive assessments, such as LCA, or the consideration of factors beyond CO<sub>2</sub> emissions in evaluating ecological impacts. Furthermore, there is a noticeable scarcity of actionable strategies and their evaluations in terms of ecological sustainability in the existing literature. In conclusion, the following key points can be highlighted:</p>
        <list list-type="order">
          <list-item>
            <p>The need for research into the environmental sustainability of digital technologies in health care is underscored by the health care sector’s significant annual contribution to greenhouse gas emissions.</p>
          </list-item>
          <list-item>
            <p>Research is required to investigate the ecological impact of digital technologies in health care beyond the scope of telemedicine. While digital technologies such as AI, electronic health records, and digital applications are highly relevant for the health care sector both at present and in the future, it is essential to intensify and deepen research in this area with regard to their sustainability. Environmental assessments that adopt a holistic approach, incorporating LCA; supply chain considerations; and, more broadly, social, ecological, and economic factors, should be prioritized.</p>
          </list-item>
          <list-item>
            <p>There is a pressing need for actionable strategies to ensure the sustainable implementation of digitalization in health care with a comprehensive evaluation of its ecological impact.</p>
          </list-item>
          <list-item>
            <p>Planetary Health should serve as the guiding framework for developing action-oriented guidelines for ecological sustainability in digitalization to address and mitigate the inherent ambivalence of digital transformation.</p>
          </list-item>
        </list>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses: Scoping Review) checklist.</p>
        <media xlink:href="jmir_v27i1e71795_app1.docx" xlink:title="DOCX File , 26 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search string.</p>
        <media xlink:href="jmir_v27i1e71795_app2.docx" xlink:title="DOCX File , 16 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AI</term>
          <def>
            <p>artificial intelligence</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">CO<sub>2</sub></term>
          <def>
            <p>carbon dioxide</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">LCA</term>
          <def>
            <p>life cycle analysis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">RQ</term>
          <def>
            <p>research question</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>Artificial intelligence–assisted technologies (DeepL; DeepL SE) [<xref ref-type="bibr" rid="ref120">120</xref>] and artificial intelligence (ChatGPT; OpenAI) [<xref ref-type="bibr" rid="ref121">121</xref>] were used in the translation and writing process to improve readability and the language of the work. The results were reviewed and edited with human oversight afterward. Correspondence and requests for materials should be addressed to MB. This review received no external funding. The research, analysis, and writing were conducted independently without financial support from any funding agencies, commercial entities, or other external organizations. All views and interpretations presented are solely those of the authors.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>MB and JE designed the scoping review. JE and JN supervised the scoping review. MB extracted the results from the database searches and uploaded them to Rayyan (Qatar Computing Research Institute). MB and JE conducted the screening of the search results. Data extraction was conducted by MB and was validated by JE and JN. MB created the visualizations and drafted the manuscript. All authors had access to the data and critically revised and edited the manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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