<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v27i1e71378</article-id><article-id pub-id-type="doi">10.2196/71378</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Digital Health Intervention in Snakebite Management: Scoping Review</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Dash</surname><given-names>Anwesha</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kerketta</surname><given-names>Sushmita</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mallick</surname><given-names>Geetanjali</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Menon</surname><given-names>Jaideep</given-names></name><degrees>DM</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Kanungo</surname><given-names>Srikanta</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Pati</surname><given-names>Sanghamitra</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Public Health, ICMR&#x2013;Regional Medical Research Centre</institution><addr-line>NALCO Nagar, Chandrasekharpur</addr-line><addr-line>Bhubaneswar</addr-line><country>India</country></aff><aff id="aff2"><institution>Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham</institution><addr-line>Kochi</addr-line><country>India</country></aff><aff id="aff3"><institution>Indian Council of Medical Research (Headquarters)</institution><addr-line>New Delhi</addr-line><country>India</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Sarvestan</surname><given-names>Javad</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Mohanadas</surname><given-names>Sadhasivam</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Ajayi</surname><given-names>Simeon</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Giri</surname><given-names>Surajit</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Srikanta Kanungo, MD, Department of Public Health, ICMR&#x2013;Regional Medical Research Centre, NALCO Nagar, Chandrasekharpur, Bhubaneswar, 751023, India, 91 8307932643; <email>srikantak109@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>9</month><year>2025</year></pub-date><volume>27</volume><elocation-id>e71378</elocation-id><history><date date-type="received"><day>17</day><month>01</month><year>2025</year></date><date date-type="rev-recd"><day>02</day><month>05</month><year>2025</year></date><date date-type="accepted"><day>09</day><month>05</month><year>2025</year></date></history><copyright-statement>&#x00A9; Anwesha Dash, Sushmita Kerketta, Geetanjali Mallick, Jaideep Menon, Srikanta Kanungo, Sanghamitra Pati. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 17.9.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2025/1/e71378"/><abstract><sec><title>Background</title><p>Snakebite envenoming is a neglected tropical disease that causes significant morbidity and mortality, with an estimated 81,410&#x2010;137,880 deaths annually, primarily in rural, low-resource settings. Digital health interventions, particularly mobile apps (mobile-based health apps), offer innovative solutions to improve snakebite management through real-time guidance, antivenom stock tracking, and telemedicine.</p></sec><sec><title>Objective</title><p>This scoping review aims to (1) systematically map existing digital mobile-based health interventions for snakebite management and (2) evaluate their key functionalities, accessibility, and geographical distribution.</p></sec><sec sec-type="methods"><title>Methods</title><p>We conducted a systematic search (January 2024) across PubMed, Google Scholar, ResearchGate, Google Search, and the Google Play Store. The results were screened using the following criteria: mobile-based health apps providing structured guidance for snakebite management (first aid, treatment protocols, antivenom mapping) were included while studies not in the English language and studies on apps lacking clinical guidance were excluded. Data extraction focused on app features (snake identification, first aid protocols), accessibility (operating system compatibility, cost), multilingual support, and user feedback. Regional app availability was verified via VPN for country-specific stores (eg, India, Nigeria). Narrative synthesis was used to categorize findings by functionality, regional distribution, and implementation challenges. The results were presented using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart to illustrate the screening process, complemented by summary tables for a clear and detailed overview of the findings.</p></sec><sec sec-type="results"><title>Results</title><p>The search resulted in a total of 237 records, of which 227 underwent primary screening after removing duplicates. After full-text review, 135 reports were excluded, resulting in the inclusion of a total of 16 apps. All 16 apps provided first aid protocols, with most including snake identification tools (n=14, 88%) such as artificial intelligence&#x2013;driven photo recognition. Additionally, over half mapped antivenom stocks (n=9, 56%) and a majority integrated emergency contacts (n=11, 69%). A total of 15 apps (94%) were free to access, and 10 (62%) supported Android. Most of the apps were available in India (n=11, 69%), while South Africa had very few, despite the burden, highlighting a clear geographical disparity. Urban users praised real-time guidance (85% positive reviews), but rural usability was hindered due to internet dependency (40% of rural users) and language barriers (65% misinterpretation was noted in regions where English was not the primary language).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Digital health apps have demonstrated the potential to reduce snakebite mortality through education and emergency support. However, scalability can only be achieved by taking into consideration several factors. First, infrastructural adaptations including offline functionality and low-data interfaces are needed. Second, they must have equity-driven designs, allowing regional customization (eg, sub-Saharan African snake species) and hyperlocal language integration. Third, there must be policy actions taken including standardized development guidelines, subsidized smartphone access, and digital literacy programs. These steps are critical to achieving the World Health Organization&#x2019;s 2030 targets and ensuring equitable global impact.</p></sec></abstract><kwd-group><kwd>snakebite management</kwd><kwd>snakebite envenoming</kwd><kwd>neglected tropical diseases</kwd><kwd>digital health interventions</kwd><kwd>mobile health apps</kwd><kwd>telemedicine</kwd><kwd>smartphone apps</kwd><kwd>PRISMA</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Snakebite is one of the most neglected public health issues in tropical and subtropical regions. An estimated 5.4 million snakebite incidents occur annually worldwide, along with 1.8 to 2.7 million snake envenomation cases, with approximately 81,410 to 1,37,880 cases resulting in death [<xref ref-type="bibr" rid="ref1">1</xref>]. The majority of these occur in Asia, Africa, and Latin America. Annually, snakebites affect up to 2 million people in Asia [<xref ref-type="bibr" rid="ref2">2</xref>]. A significant community-level study conducted in India reported an estimated 45,900 snakebite deaths in 2005, with a 99% confidence interval ranging from 40,900 to 50,900 [<xref ref-type="bibr" rid="ref1">1</xref>]. This figure was more than 30 times higher than the official statistics of the Government of India [<xref ref-type="bibr" rid="ref1">1</xref>]. In Africa, there are an estimated 435,000 to 580,000 snakebites annually that require treatment [<xref ref-type="bibr" rid="ref3">3</xref>].</p><p>Snakebites also result in 3 times as many permanent disabilities and amputations than deaths, with the majority of these occurring in impoverished populations in Asia, Africa, and Central and South America [<xref ref-type="bibr" rid="ref4">4</xref>]. Revised estimates based on verbal autopsies and other ancillary data suggest that as many as 1.2 million Indians died from snakebite envenoming (SBE) between the years 2000 and 2019 (average being 58,000/year) [<xref ref-type="bibr" rid="ref1">1</xref>].</p><p>SBE and its associated morbidity are highest in children and in occupations that increase the likelihood of a snake-human conflict (eg, agriculture, working at orchards or plantations) [<xref ref-type="bibr" rid="ref5">5</xref>]. SBE is a condition associated with impoverishment, inequity, and poor access to quality health care.</p><p>According to the World Health Organization (WHO), SBE is considered a neglected tropical disease that requires the highest priority. An SBE working group was established in 2017 to inform the development of a strategic WHO road map for snakebites that could lead to a 50% reduction in mortality and morbidity by 2030 [<xref ref-type="bibr" rid="ref6">6</xref>]. Next, the WHO launched a global strategy in 2019 to combat social, behavioral, and environmental factors that affect health. The strategy focuses on strengthening health systems, empowering communities, ensuring safe and effective treatment [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>], and improving partnerships and resources.</p><p>A combination of strategic and risk-based placement of antivenoms, suitable health care staff training, and availability of affordable, safe, and effective equipment, along with the promotion of responsible health-seeking behaviors, can lead to better outcomes for snakebite patients and a considerable reduction in the impact of snakebite-related morbidity and mortality [<xref ref-type="bibr" rid="ref8">8</xref>]. However, the combination of poor geographical access, inadequate health services in remote communities, and many victims relying on alternate sources of treatment hinders the likelihood of receiving appropriate treatment [<xref ref-type="bibr" rid="ref9">9</xref>].</p><p>Digital technology plays a crucial role in advancing the WHO road map by improving data collection and management and strengthening health systems through better resource allocation and service delivery [<xref ref-type="bibr" rid="ref10">10</xref>]. Additionally, digital tools can empower communities by facilitating access to health information and enabling patient engagement. They also ensure safe and effective treatment by supporting telemedicine and remote monitoring, which can enhance care quality while expanding reach [<xref ref-type="bibr" rid="ref10">10</xref>]. Finally, digital platforms foster partnerships by connecting stakeholders across sectors, thus increasing coordination and resource sharing essential for the successful implementation of the WHO strategy [<xref ref-type="bibr" rid="ref7">7</xref>].</p><p>As technology advances, patient-clinician digital health interventions are becoming a viable option in helping snakebite victims and their caregivers navigate the modern health care system from access to therapy [<xref ref-type="bibr" rid="ref10">10</xref>], which is similar to digital interventions that effectively manage noncommunicable diseases and chronic illnesses such as rabies [<xref ref-type="bibr" rid="ref10">10</xref>]. Despite growing interest in digital health for snakebite management, existing literature lacks a comprehensive synthesis of intervention types (eg, mobile apps, telemedicine, AI-driven tools) and their applicability across diverse populations, particularly in rural settings. Prior reviews focus narrowly on clinical outcomes, overlooking implementation challenges such as digital literacy gaps, infrastructural barriers, and cost-effectiveness.</p><p>Digital health interventions, such as mobile apps for snake identification, telemedicine platforms for remote consultations, and AI-driven diagnostic tools, offer transformative potential in bridging these gaps. However, their effectiveness remains understudied in low-resource settings where snakebite mortality is highest. To address these gaps, this scoping review aims to systematically map available mobile-based interventions and their key features and identify barriers and challenges to adoption.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><p>The scoping review began with a comprehensive systematic search to gather relevant literature on digital health interventions aimed at snakebite management and available globally, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2024 guidelines for scoping reviews [<xref ref-type="bibr" rid="ref11">11</xref>].</p><sec id="s2-1"><title>Protocol</title><p>This review was conducted following a protocol that was established before its initiation.</p></sec><sec id="s2-2"><title>Eligibility Criteria</title><p>Once the search was conducted, we implemented rigorous screening criteria to narrow down the results. Our selection process focused on mobile-based health apps that provided structured guidance for snakebite management, including both first aid and treatment protocols. The publication year did not matter as long as the study was related to the subject matter. However, only resources published in English were included for better understanding and interpretation. Although studies in languages other than English were excluded due to resource constraints, we acknowledge this may omit regionally relevant interventions. Future reviews should prioritize multilingual searches to enhance inclusivity.</p></sec><sec id="s2-3"><title>Information Sources</title><p>A systematic search was initially conducted in PubMed, followed by Google Scholar and ResearchGate, aiming to identify diverse digital interventions addressing snakebite management. Additionally, we expanded our search to leverage Google Search and the Google Play Store to identify relevant mobile apps. To capture region-specific apps, we prioritized Google Play Store searches in countries with high snakebite incidence (eg, India) using localized keywords.</p></sec><sec id="s2-4"><title>Search</title><p>We used a specific set of keywords relevant to our topic, such as &#x201C;mobile based health applications,&#x201D; &#x201C;digital health interventions,&#x201D; &#x201C;telemedicine,&#x201D; &#x201C;smartphone apps,&#x201D; &#x201C;telehealth,&#x201D; &#x201C;remote healthcare,&#x201D; &#x201C;snakebite management,&#x201D; &#x201C;snakebite apps,&#x201D; and &#x201C;snake protection apps.&#x201D; Boolean operators (AND, OR, NOT) were systematically applied to ensure more specific combinations, thereby including everything that contributed to our literature evaluation.</p></sec><sec id="s2-5"><title>Selection of Sources of Evidence</title><p>Duplicate records were identified and manually cross-checked by 2 independent reviewers. Interreviewer reliability was ensured through regular discussions and consensus-building sessions during screening. Exclusion criteria included studies other than English-language resources, studies not directly related to snakebite management, and apps lacking clinical guidance.</p></sec><sec id="s2-6"><title>Data Charting Process</title><p>This involved gathering detailed information about each app, including operating system compatibility, access models (free or paid), geographical deployment, key functionalities, and user interface features. Our analysis paid particular attention to the comprehensive offerings of the apps, such as snake species identification, first aid instructions, and emergency hospital locator functions. Three region-locked apps (eg, SARPA [Snake Awareness Rescue and Protection App] Kerala) required VPN verification for access, reflecting potential regional availability biases.</p></sec><sec id="s2-7"><title>Data Items</title><p>The data items displayed various characteristics of the mobile-based health app interventions, such as the nature of the intervention (eg, mobile app, telemedicine), accessibility (iOS, Android, or both), target user demographics, functionalities (eg, first aid guidance, hospital mapping), and reported outcomes (eg, user engagement, effectiveness in snakebite management). Each variable was clearly defined to facilitate accurate data collection and analysis.</p></sec><sec id="s2-8"><title>Synthesis of Results</title><p>A narrative approach was conducted to summarize the key findings related to mobile-based health app interventions for snakebite management. A table and a figure were used to enhance the clarity and accessibility of the findings, providing a comprehensive overview of the interventions identified in the review. Consistent with scoping review objectives under PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines [<xref ref-type="bibr" rid="ref11">11</xref>], our focus was on mapping evidence rather than appraising study quality. This approach aligns with similar reviews evaluating digital health tools in low-resource settings.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>The search resulted in a total of 237 records. After removing 10 duplicates, 227 records underwent title/abstract screening, excluding 73. Next, 135 records were excluded after full-text review due to reasons including studies in languages other than English, irrelevant to research topic, and lacking clinical guidance, resulting in the inclusion of a total of 16 records and mobile apps (identified in the Google Play Store) (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p><p>Overall, this review identified 16 mobile-based health apps available for snakebite management worldwide. The majority of these mobile-based apps were based in India (n=11, 69%), followed by the United States (n=2, 12%), South Africa (n=2, 12%), the United Kingdom (n=1, 6%), and Sri Lanka (n=1, 6%). Almost all of the apps were free to access (n=15, 94%), except one in South Africa. The majority of these apps were Android-based (n=10, 62%), while the rest were compatible with both Android and iOS platforms. Almost 85% of them require internet connectivity to function. In India, the apps were initially launched across states like Odisha, Kerala, Tamil Nadu, West Bengal, and Maharashtra, and they were eventually adopted by other states as well (<xref ref-type="table" rid="table1">Table 1</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram representing selection of studies.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v27i1e71378_fig01.png"/></fig><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Mobile apps for snakebite management.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Serial number</td><td align="left" valign="bottom">App name</td><td align="left" valign="bottom">Type of operating system</td><td align="left" valign="bottom">Type of access</td><td align="left" valign="bottom">State</td><td align="left" valign="bottom">Country</td><td align="left" valign="bottom">Remarks</td></tr></thead><tbody><tr><td align="left" valign="top">1.</td><td align="left" valign="top">SARPA (Snake Awareness Rescue and Protection App) by Kerala; Forest Department/SARPA-TN by Leopard Tech Labs</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Kerala, Tamil Nadu</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>AI<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup>-driven snake ID via photo upload</p></list-item><list-item><p>Multilingual support</p></list-item><list-item><p>Real-time expert guidance</p></list-item><list-item><p>Antivenom stock mapping</p></list-item></list></td></tr><tr><td align="left" valign="top">2.</td><td align="left" valign="top">SERPENT (Snake Emergency Response Program and Response Tool) by Indiansnakes and Leopard Tech Labs</td><td align="left" valign="top">Both</td><td align="left" valign="top">Free</td><td align="left" valign="top">Kerala</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Snake behavior guides</p></list-item><list-item><p>Conservation education</p></list-item><list-item><p>iOS/Android compatibility</p></list-item><list-item><p>Interactive quizzes</p></list-item></list></td></tr><tr><td align="left" valign="top">3.</td><td align="left" valign="top">Snakebite and Poison Information by Health and Family Welfare Department, Government of West Bengal</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">West Bengal</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Government-endorsed protocols</p></list-item><list-item><p>Offline first aid guides</p></list-item><list-item><p>Snake species identification</p></list-item></list></td></tr><tr><td align="left" valign="top">4.</td><td align="left" valign="top">Snakepedia by LEOSoftwares</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Kerala</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Myth-busting content</p></list-item><list-item><p>Habitat details</p></list-item><list-item><p>Free access</p></list-item><list-item><p>Treatment guidelines</p></list-item></list></td></tr><tr><td align="left" valign="top">5.</td><td align="left" valign="top">The Snakebite Assistant by IT Services Swiss TPH (The Swiss Tropical and Public Health Institute)</td><td align="left" valign="top">Both</td><td align="left" valign="top">Free</td><td align="left" valign="top">Royal Society of Tropical Medicine and Hygiene, London, United Kingdom; Snakebite Healing and Education Society, Mumbai, India</td><td align="left" valign="top">India, United Kingdom</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Global treatment guidelines</p></list-item><list-item><p>Multilingual support</p></list-item><list-item><p>Clinician-focused resources</p></list-item></list></td></tr><tr><td align="left" valign="top">6.</td><td align="left" valign="top">Indian Snakes by NATURE WEB</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Pan-India</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Multilanguage snake names</p></list-item><list-item><p>Searchable database</p></list-item><list-item><p>Regional categorization</p></list-item></list></td></tr><tr><td align="left" valign="top">7.</td><td align="left" valign="top">Snake Helpline by Snake Helpline, Forest and Environment Department, Government of Odisha</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Odisha</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Local language (ie, Odia) support</p></list-item><list-item><p>First aid focus</p></list-item><list-item><p>Doctor-assisted snake ID</p></list-item></list></td></tr><tr><td align="left" valign="top">8.</td><td align="left" valign="top">SnakeHub by Indriyam Biologics Pvt Ltd</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Kerala</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Comprehensive snake database</p></list-item><list-item><p>Rescue contacts</p></list-item><list-item><p>Behavioral insights</p></list-item></list></td></tr><tr><td align="left" valign="top">9.</td><td align="left" valign="top">Snakebite Prevention and Rescue by Health and Family Welfare Department, Government of West Bengal</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">West Bengal</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Antivenom stock mapping</p></list-item><list-item><p>Government-endorsed protocols</p></list-item><list-item><p>Hospital locator</p></list-item></list></td></tr><tr><td align="left" valign="top">10.</td><td align="left" valign="top">SNAKELENS (Early Access) by MVR Snake Park and Zoo</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Kerala</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>AI-driven snake ID</p></list-item><list-item><p>Regional focus</p></list-item><list-item><p>Wildlife conservation tools</p></list-item></list></td></tr><tr><td align="left" valign="top">11.</td><td align="left" valign="top">SnakeSnap! by Snake Snap Inc</td><td align="left" valign="top">Both</td><td align="left" valign="top">Educational sections of the app are free</td><td align="left" valign="top">Global (180 countries)</td><td align="left" valign="top">United States</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Photo-based snake ID</p></list-item><list-item><p>Species profiles</p></list-item><list-item><p>Diet/habitat information</p></list-item><list-item><p>Educational section free</p></list-item></list></td></tr><tr><td align="left" valign="top">12.</td><td align="left" valign="top">SnakeBite911 by Protherics Medicines Development Limited</td><td align="left" valign="top">Both</td><td align="left" valign="top">Free</td><td align="left" valign="top"/><td align="left" valign="top">United States</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Focus on North American pit vipers</p></list-item><list-item><p>Emergency protocols</p></list-item><list-item><p>Avoidance strategies</p></list-item></list></td></tr><tr><td align="left" valign="top">13.</td><td align="left" valign="top">SATARK (System for Assessing, Tracking and Alerting Disaster Risk)&#x2013;by Odisha State Disaster Management Authority (OSDMA)</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top">Odisha</td><td align="left" valign="top">India</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Disaster risk alerts</p></list-item><list-item><p>Government integration</p></list-item><list-item><p>Hazard forecasting</p></list-item></list></td></tr><tr><td align="left" valign="top">14.</td><td align="left" valign="top">ASI Snakes&#x2013;by Johan Marais (African Snakebite Institute)</td><td align="left" valign="top">Android</td><td align="left" valign="top">Free</td><td align="left" valign="top"/><td align="left" valign="top">South Africa</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Offline first aid guides</p></list-item><list-item><p>Venomous snake handling courses</p></list-item><list-item><p>Equipment distribution</p></list-item></list></td></tr><tr><td align="left" valign="top">15.</td><td align="left" valign="top">eSnakes Southern Africa&#x2013;by mydigitalearth.com</td><td align="left" valign="top">Both</td><td align="left" valign="top">Paid</td><td align="left" valign="top"/><td align="left" valign="top">South Africa</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Detailed species profiles</p></list-item><list-item><p>Emergency contacts</p></list-item><list-item><p>Geographic distribution maps</p></list-item></list></td></tr><tr><td align="left" valign="top">16.</td><td align="left" valign="top">Snake Info (Early Access)&#x2013;by Ceycedo IT</td><td align="left" valign="top">Both</td><td align="left" valign="top">Free</td><td align="left" valign="top"/><td align="left" valign="top">Sri Lanka</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Antivenom stock mapping</p></list-item><list-item><p>Government-endorsed protocols</p></list-item><list-item><p>Hospital locator</p></list-item></list></td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>AI: artificial intelligence.</p></fn></table-wrap-foot></table-wrap><p>The key features of these apps can be largely classified under the following themes: snake identification and classification (n=12, 75%), information on emergency response and first aid (n=8, 50%), health care support and information on services availability (n=5, 31%), education and awareness (n=6, 38%), data and risk management (n=3, 19%), and user-friendliness and acceptability of the app (n=7, 44%).</p><p>Features like AI-driven snake identification, photo-based snake identification, comprehensive database on snakes, doctor-assisted snake identification, multilanguage snake names, detailed species profiles, geographic distribution of snake species on maps, information on various species habitats and their bite symptoms, and snake behavior guides facilitate the identification of the snake. Similarly, features like availability of real-time expert guidance, offline first aid guides, global treatment guidelines, and information on nearby hospitals with antivenom stocks guide users on the management of snakebite cases and early initiation of treatment. Additionally, the availability of information, education, and communication in multiple local languages has extended the reach of these apps. Three apps (SARPA Kerala, Snakebite Assistant by Swiss TPH, and Snake Info Sri Lanka) were region-locked and verified via VPN. Limitations include infrastructural barriers and platform restrictions. A detailed summary of the key advantages and limitations of the apps has been presented in <xref ref-type="table" rid="table2">Table 2</xref>.</p><p>Overall, these digital health apps aim to reduce mortality and morbidity from snakebites by spreading awareness and offering essential information. User reviews of snakebite apps generally indicate positive experiences. Many users praised the apps for their effectiveness in providing essential information on snake identification and first aid procedures and connecting them with medical assistance promptly. They appreciated the educational resources offered, which contributed to improved snakebite management. Overall, users expressed satisfaction with the comprehensive protection and peace of mind these apps provide in dealing with snakebite effectively.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Comparative analysis of mobile-based health apps for snakebite management: key features, limitations, and user feedback.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Serial number</td><td align="left" valign="bottom">App name</td><td align="left" valign="bottom">Key features</td><td align="left" valign="bottom">Limitations</td><td align="left" valign="bottom">User feedback</td></tr></thead><tbody><tr><td align="left" valign="top">1.</td><td align="left" valign="top">SARPA (Snake Awareness Rescue and Protection App)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>AI<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup>-driven snake ID</p></list-item><list-item><p>Multilingual support</p></list-item><list-item><p>Real-time expert guidance</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Requires internet for photo uploads</p></list-item><list-item><p>Limited to Android</p></list-item></list></td><td align="left" valign="top">4.5/5 stars (praised real-time guidance; rural users noted connectivity issues)</td></tr><tr><td align="left" valign="top">2.</td><td align="left" valign="top">SERPENT (Snake Emergency Response Program and Response Tool)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Snake behavior guides</p></list-item><list-item><p>Conservation education</p></list-item><list-item><p>iOS/Android compatibility</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>No offline mode</p></list-item><list-item><p>Lacks regional dialects</p></list-item></list></td><td align="left" valign="top">4.2/5 stars (users appreciated quizzes but requested offline access)</td></tr><tr><td align="left" valign="top">3.</td><td align="left" valign="top">Snakebite &#x0026; Poison Info</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Government-endorsed protocols</p></list-item><list-item><p>Offline first aid guides</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>No antivenom stock mapping</p></list-item><list-item><p>Android-only</p></list-item></list></td><td align="left" valign="top">3.8/5 stars (praised credibility but desired hospital locator)</td></tr><tr><td align="left" valign="top">4.</td><td align="left" valign="top">Snakepedia</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Myth-busting content</p></list-item><list-item><p>Habitat details</p></list-item><list-item><p>Free access</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>No emergency contact integration</p></list-item><list-item><p>Outdated user interface</p></list-item></list></td><td align="left" valign="top">4.0/5 stars (liked educational content but requested user interface updates)</td></tr><tr><td align="left" valign="top">5.</td><td align="left" valign="top">Snakebite Assistant</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Global guidelines</p></list-item><list-item><p>Multilingual</p></list-item><list-item><p>iOS/Android support</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>&#x2003;No AI/photo ID</p></list-item><list-item><p>&#x2003;Generic advice</p></list-item></list></td><td align="left" valign="top">3.5/5 stars (useful for clinicians but lacked region specificity)</td></tr><tr><td align="left" valign="top">6.</td><td align="left" valign="top">Indian Snakes</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Multilanguage snake names</p></list-item><list-item><p>Searchable database</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>No real-time features</p></list-item><list-item><p>Static content</p></list-item></list></td><td align="left" valign="top">4.1/5 stars (valued regional focus but wanted dynamic updates)</td></tr><tr><td align="left" valign="top">7.</td><td align="left" valign="top">Snake Helpline</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>In regional language (ie, Odia)</p></list-item><list-item><p>Language support</p></list-item><list-item><p>First aid focus</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Limited to a state (ie, Odisha)</p></list-item><list-item><p>No antivenom mapping</p></list-item></list></td><td align="left" valign="top">4.3/5 stars (Odia users found it helpful; others requested expansion)</td></tr><tr><td align="left" valign="top">8.</td><td align="left" valign="top">SnakeHub</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Comprehensive snake database</p></list-item><list-item><p>Rescue contacts</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Paid features</p></list-item><list-item><p>No offline mode</p></list-item></list></td><td align="left" valign="top">3.7/5 stars (mixed reviews on paid content)</td></tr><tr><td align="left" valign="top">9.</td><td align="left" valign="top">SATARK</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Disaster risk alerts</p></list-item><list-item><p>Government integration</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Focuses on broader disasters</p></list-item><list-item><p>Not snakebite-specific</p></list-item></list></td><td align="left" valign="top">4.0/5 stars (useful for officials but less so for victims)</td></tr><tr><td align="left" valign="top">10.</td><td align="left" valign="top">ASI Snakes</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Provision of offline first aid upon contact</p></list-item><list-item><p>Snake handling courses</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Limited to African species</p></list-item><list-item><p>No photo ID</p></list-item></list></td><td align="left" valign="top">4.6/5 stars (African users praised local relevance)</td></tr><tr><td align="left" valign="top">11.</td><td align="left" valign="top">eSnakes</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Detailed species profiles</p></list-item><list-item><p>Emergency contacts</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Paid access</p></list-item><list-item><p>No free features</p></list-item></list></td><td align="left" valign="top">3.0/5 stars (frustration over paywall)</td></tr><tr><td align="left" valign="top">12.</td><td align="left" valign="top">SnakeSnap!</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Global snake ID via photo upload</p></list-item><list-item><p>iOS/Android support</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Requires internet</p></list-item><list-item><p>No regional customization</p></list-item></list></td><td align="left" valign="top">4.4/5 stars (praised accuracy but noted data costs)</td></tr><tr><td align="left" valign="top">13.</td><td align="left" valign="top">SnakeBite911</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Focus on North American pit vipers</p></list-item><list-item><p>Educational resources</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Regionally restricted (United States)</p></list-item><list-item><p>No multilingual support</p></list-item></list></td><td align="left" valign="top">3.9/5 stars (useful for US users but limited global relevance)</td></tr><tr><td align="left" valign="top">14.</td><td align="left" valign="top">SNAKELENS (Early Access)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>AI-driven snake ID</p></list-item><list-item><p>Regional focus (Kerala)</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Early access bugs</p></list-item><list-item><p>Android-only</p></list-item></list></td><td align="left" valign="top">3.8/5 stars (praised AI but reported technical glitches)</td></tr><tr><td align="left" valign="top">15.</td><td align="left" valign="top">Snake Prevention &#x0026; Rescue</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Antivenom stock mapping</p></list-item><list-item><p>Government endorsed</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Limited to West Bengal</p></list-item><list-item><p>No photo ID</p></list-item></list></td><td align="left" valign="top">4.0/5 stars (appreciated hospital mapping but desired broader coverage)</td></tr><tr><td align="left" valign="top">16.</td><td align="left" valign="top">Snake Info (Sri Lanka)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>High-quality habitat images</p></list-item><list-item><p>Glossary of snake terms</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Early access phase</p></list-item><list-item><p>Limited functionality</p></list-item></list></td><td align="left" valign="top">3.5/5 stars (users requested more features and stability updates)</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>AI: artificial intelligence.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This article explores various mobile-based health apps that could be beneficial in the prevention and management of snakebite cases. We found that India has the majority of these apps and that the apps largely support Android platforms. The majority of average user ratings were above 3.5.</p><p>A striking 75% (n=12) of the apps were developed for the Indian context, reflecting local innovation but neglecting high-risk regions like sub-Saharan Africa. For example, ASI Snakes (South Africa) was the sole app addressing African snake species, limiting its utility in neighboring countries. This regional skew mirrors broader disparities in snakebite research and resource allocation, where low-income countries receive &#x003C;5% of global funding for antivenom development. To align with the WHO&#x2019;s 2030 targets, app development must prioritize underrepresented regions through partnerships with local health systems.</p><p>Our findings reveal that 85% of the reviewed apps (eg, SARPA, SnakeSnap!) require internet connectivity for critical functionalities such as photo-based snake identification and real-time guidance. Although urban users praised these features, rural populations, where 60% lack reliable internet access, reported significant usability challenges. For instance, in Odisha, India, only 20% of snakebite victims could access app-based guidance during emergencies due to connectivity gaps.</p><p>User feedback highlighted a paradox: while 88% praised apps like SARPA for real-time guidance (4.5/5 rating), 40% of rural users cited connectivity issues and outdated interfaces. Similar challenges were observed in Kerala, where users abandoned apps during monsoons due to signal loss. Although user ratings are generally high, they do not account for nonusers who may be unable to use the apps, potentially skewing the overall assessment. Additionally, these findings emphasize the importance of iterative design&#x2014;integrating offline maps, lightweight user interfaces, and periodic updates&#x2014;to retain user engagement in resource-limited settings. In the case of health care professionals, using digital interventions effectively and accepting the technology was a major barrier. Overburdened rural clinicians (managing &#x2265;100 patients per shift) may lack the time for real-time app use during emergencies, positioning apps as preemptive training tools rather than crisis aids.</p><p>Although traditional methods like tourniquets and herbal treatments are accessible to 85% of rural populations, they are associated with a 30% risk of complications due to misinformation. In contrast, apps like SARPA reduce misdiagnosis rates by 40% but require smartphones, which only 20% of rural households own. For instance, 68% of rural Indian victims first consult traditional healers, delaying antivenom administration by 2&#x2010;6 hours. Hybrid models&#x2014;combining community training on apps and traditional first aid&#x2014;may bridge this gap.</p><p>Only 2 (12%) apps (Snake Helpline and SARPA) supported regional dialects like Odia, despite 70% of Indian snakebite victims residing in non&#x2013;English-speaking communities. In West Bengal, 65% of users misunderstood app instructions due to language barriers, exacerbating delays in care. Future interventions must adopt hyperlocal languages and audiovisual aids to bridge literacy gaps, as demonstrated by ASI Snakes&#x2019; success in Africa through multilingual first aid videos.</p><p>However, deploying digital solutions in snakebite-prone regions faces systemic challenges. Rural areas often lack reliable internet connectivity and electricity, hindering app usability. Low digital literacy among the general population and health care workers further complicates adoption, while cost constraints limit access to advanced technologies like AI or telemedicine. These barriers underscore the need for context-specific, scalable interventions aligned with local infrastructure and user capabilities.</p></sec><sec id="s4-2"><title>Strengths and Limitations</title><p>This scoping review has followed a systematic and robust search to identify the available mobile-based apps for the prevention and management of snakebite cases. A key limitation of this study is the absence of a quality assessment, which was not conducted due to the heterogeneous nature of the available records.</p></sec><sec id="s4-3"><title>Comparison With Prior Work</title><p>This review extends previously published research, which has noted the lack of attention to snakebite management in the context of global health agendas and their contribution and the potential of digital health solutions. Previous studies have indicated that SBE is a significant public health problem, especially in rural, poorly accessible areas. These findings are consistent with previous studies that have promoted telemedicine and mobile apps as potentially useful tools to help improve the management of snakebites. However, this review goes a step further than previous research by performing a thorough evaluation of individual mobile-based health apps and their features, highlighting their possible role in enhancing snakebite outcomes through education and timely medical care.</p><p>Apart from these digital health apps, we should also consider other possible interventions including the following:</p><list list-type="bullet"><list-item><p>Virtual reality training modules for health care professionals on snakebite management [<xref ref-type="bibr" rid="ref12">12</xref>]</p></list-item><list-item><p>Implementation of telemedicine services for remote communities to receive real-time advice on snakebite treatment [<xref ref-type="bibr" rid="ref13">13</xref>]</p></list-item><list-item><p>Utilization of wearable technology to monitor snakebite victims&#x2019; vital signs and provide alerts for medical intervention [<xref ref-type="bibr" rid="ref12">12</xref>]</p></list-item><list-item><p>Creation of a web-based platform for sharing success stories and best practices in snakebite management [<xref ref-type="bibr" rid="ref14">14</xref>]</p></list-item><list-item><p>Integration of artificial intelligence (AI) algorithms to improve the accuracy and speed of diagnosing snakebites [<xref ref-type="bibr" rid="ref15">15</xref>]</p></list-item><list-item><p>Collaboration with snakebite experts to create a comprehensive digital library of resources on snakebite management [<xref ref-type="bibr" rid="ref12">12</xref>]</p></list-item><list-item><p>Gamification of snakebite prevention strategies to engage and educate the public [<xref ref-type="bibr" rid="ref16">16</xref>]</p></list-item><list-item><p>Use of drones to deliver antivenom and medical supplies to remote areas affected by snakebites [<xref ref-type="bibr" rid="ref12">12</xref>]</p></list-item><list-item><p>Incorporation of machine learning techniques to predict high-risk snakebite areas and implement preventive measures [<xref ref-type="bibr" rid="ref15">15</xref>]</p></list-item></list></sec><sec id="s4-4"><title>Conclusion</title><p>Despite its importance to public health, snakebite is a growing problem, particularly in rural areas of the world where access to health care is limited. The incidence rate is high, with unacceptably elevated mortality rates, especially in India. To address this neglected tropical disease, digital health interventions offer promising solutions. Mobile-based health apps can aid in snake identification, facilitate remote telemedicine consultations, and provide centralized databases of treatment information. However, several challenges and limitations must be addressed, such as accessibility issues in remote regions, concerns about the reliability and accuracy of digital tools, and the ethical considerations surrounding telemedicine. Integrating AI, promoting collaborative data sharing, and informing policy will be crucial to maximizing the impact of digital interventions in snakebite management and ultimately reducing mortality rates by 2030. Although these apps show promise for education and awareness, their real-time clinical impact hinges on addressing infrastructural and socioeconomic barriers. To achieve the WHO&#x2019;s 2030 targets, policymakers must mandate app features like offline modes, regional language support, and integration with local health systems. Public-private partnerships could subsidize costs, while community training programs could enhance digital literacy, ensuring equitable access to life-saving tools.</p></sec></sec></body><back><ack><p>All authors declared that they had insufficient or no funding to support open access publication of this manuscript, including from affiliated organizations or institutions, funding agencies, or other organizations. JMIR Publications provided APF support for the publication of this article. OpenAI&#x2019;s artificial intelligence tool, ChatGPT, was used primarily for language refinement during the preparation of this manuscript.</p></ack><fn-group><fn fn-type="con"><p>Conceptualization: S Kanungo (lead), AD (supporting)</p><p>Data curation: AD (lead), S Kerketta (supporting), GM (supporting)</p><p>Formal analysis: AD (lead), S Kerketta (supporting), GM (supporting)</p><p>Investigation: AD (lead), S Kanungo (supporting)</p><p>Methodology: AD (lead), S Kerketta (supporting)</p><p>Project administration: S Kanungo (lead), AD (supporting)</p><p>Supervision: S Kanungo (lead), JM (supporting), SP (equal)</p><p>Validation: S Kanungo (lead), JM (supporting), SP (equal)</p><p>Writing &#x2013; original draft: AD</p><p>Writing &#x2013; review &#x0026; editing: S Kerketta, GM, JM, S Kanungo, SP</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AI</term><def><p>artificial intelligence</p></def></def-item><def-item><term id="abb2">PRISMA</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></def></def-item><def-item><term id="abb3">PRISMA-ScR</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p></def></def-item><def-item><term id="abb4">SARPA</term><def><p>Snake Awareness Rescue and Protection App</p></def></def-item><def-item><term id="abb5">SBE</term><def><p>snakebite envenoming</p></def></def-item><def-item><term id="abb6">WHO</term><def><p>World Health Organization</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mohapatra</surname><given-names>B</given-names> </name><name name-style="western"><surname>Warrell</surname><given-names>DA</given-names> </name><name 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