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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e69657</article-id>
      <article-id pub-id-type="pmid">40354636</article-id>
      <article-id pub-id-type="doi">10.2196/69657</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Sarvestan</surname>
            <given-names> Javad</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kondapally</surname>
            <given-names>Saritha</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Alnuami</surname>
            <given-names>Saad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Butera</surname>
            <given-names>Gisela</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Lu</surname>
            <given-names>Yi-An</given-names>
          </name>
          <degrees>MSN</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0004-9089-1309</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Lin</surname>
            <given-names>Hui-Chen</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8074-8884</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Tsai</surname>
            <given-names>Pei-Shan</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>School of Nursing</institution>
            <institution>College of Nursing</institution>
            <institution>Taipei Medical University</institution>
            <addr-line>No.250, Wuxing Street, Xinyi District</addr-line>
            <addr-line>Taipei, 110</addr-line>
            <country>Taiwan</country>
            <phone>886 2 27361661 ext 6321</phone>
            <email>ptsai@tmu.edu.tw</email>
          </address>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1274-574X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>School of Nursing</institution>
        <institution>College of Nursing</institution>
        <institution>Taipei Medical University</institution>
        <addr-line>Taipei</addr-line>
        <country>Taiwan</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Research Center in Nursing Clinical Practice</institution>
        <institution>Wan Fang Hospital, Taipei Medical University</institution>
        <addr-line>Taipei</addr-line>
        <country>Taiwan</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Department of Nursing and Center for Nursing and Healthcare Research in Clinical Practice Application</institution>
        <institution>Wan Fang Hospital, Taipei Medical University</institution>
        <addr-line>Taipei</addr-line>
        <country>Taiwan</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Research Center of Sleep Medicine</institution>
        <institution>Taipei Medical University Hospital</institution>
        <addr-line>Taipei</addr-line>
        <country>Taiwan</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Pei-Shan Tsai <email>ptsai@tmu.edu.tw</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>12</day>
        <month>5</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e69657</elocation-id>
      <history>
        <date date-type="received">
          <day>5</day>
          <month>12</month>
          <year>2024</year>
        </date>
        <date date-type="rev-request">
          <day>5</day>
          <month>3</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>16</day>
          <month>3</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>12</day>
          <month>4</month>
          <year>2025</year>
        </date>
      </history>
      <copyright-statement>©Yi-An Lu, Hui-Chen Lin, Pei-Shan Tsai. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 12.05.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e69657" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>College students and young adults (18-25 years) frequently experience poor sleep quality, with insomnia being particularly prevalent among this population. Given the widespread use of digital devices in the modern world, electronic device–based sleep interventions present a promising solution for improving sleep outcomes. However, their effects in this population remain underexplored.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>We aimed to synthesize current evidence on the effectiveness of electronic device–based sleep interventions in enhancing sleep outcomes among college students and young adults.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>In total, 5 electronic databases (PubMed, CINAHL, Cochrane Library, Embase, and Web of Science) were searched to identify randomized controlled trials on digital sleep interventions. Sleep interventions, including cognitive behavioral therapy for insomnia, mindfulness, and sleep education programs delivered via web-based platforms or mobile apps, were evaluated for their effects on sleep quality, sleep parameters, and insomnia severity. Pooled estimates of postintervention and follow-up effects were calculated using Hedges <italic>g</italic> and 95% CIs under a random-effects model. Heterogeneity was assessed with <italic>I</italic><sup>2</sup> statistics, and moderator and meta-regression analyses were performed to explore sources of heterogeneity. Evidence quality was evaluated using the Grading of Recommendations Assessment, Development, and Evaluations framework.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>This study included 13 studies involving 5251 participants. Digital sleep interventions significantly improved sleep quality (Hedges <italic>g</italic>=−1.25, 95% CI −1.83 to −0.66; <italic>I</italic><sup>2</sup>=97%), sleep efficiency (Hedges <italic>g</italic>=0.62, 95% CI 0.18-1.05; <italic>I</italic><sup>2</sup>=60%), insomnia severity (Hedges <italic>g</italic>=−4.08, 95% CI −5.14 to −3.02; <italic>I</italic><sup>2</sup>=99%), dysfunctional beliefs and attitudes about sleep (Hedges <italic>g</italic>=−1.54, 95% CI −3.33 to −0.99; <italic>I</italic><sup>2</sup>=85%), sleep hygiene (Hedges <italic>g</italic>=−0.19, 95% CI −0.34 to −0.03; <italic>I</italic><sup>2</sup>=0%), and sleep knowledge (Hedges <italic>g</italic>=−0.27, 95% CI 0.09-0.45; <italic>I</italic><sup>2</sup>=0%). The follow-up effects were significant for sleep quality (Hedges <italic>g</italic>=−0.53, 95% CI −0.96 to −0.11; <italic>I</italic><sup>2</sup>=78%) and insomnia severity (Hedges <italic>g</italic>=−2.65, 95% CI −3.89 to −1.41; <italic>I</italic><sup>2</sup>=99%). Moderator analyses revealed several significant sources of heterogeneity in the meta-analysis examining the effects of digital sleep interventions on sleep outcomes. Variability in sleep quality was influenced by the sleep assessment tool (<italic>P</italic>&#60;.001), intervention type and duration (<italic>P</italic>=.001), therapist guidance (<italic>P</italic>&#60;.001), delivery mode (<italic>P</italic>=.002), history of insomnia (<italic>P</italic>&#60;.001), and the use of intention-to-treat analysis (<italic>P</italic>=.001). Heterogeneity in insomnia severity was primarily attributed to differences in the sleep assessment tool (<italic>P</italic>&#60;.001), while the effect size on sleep efficiency varied based on intervention duration (<italic>P</italic>=.02). The evidence quality ranged from moderate to very low certainty across measured outcomes.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Digital sleep interventions are effective in improving sleep quality and reducing insomnia severity, with moderate effects on dysfunctional beliefs and attitudes about sleep, sleep hygiene, and sleep knowledge. These interventions offer a viable approach to managing sleep problems in college students and young adults.</p>
        </sec>
        <sec sec-type="trial registration">
          <title>Trial Registration</title>
          <p>PROSPERO CRD42024595126; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024595126</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>emerging adults</kwd>
        <kwd>insomnia</kwd>
        <kwd>sleep quality</kwd>
        <kwd>technology-assisted sleep interventions</kwd>
        <kwd>undergraduate students</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>College students and young adults aged between 18 and 25 years frequently experience poor sleep quality and insufficient sleep duration [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>] accompanied by a high prevalence of insomnia. Studies have reported that 18.5% of college students have insomnia, whereas 22.6% of young adults experience difficulty falling asleep; these rates are higher than those observed in the general population [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. Adequate sleep is essential for maintaining overall health, cognitive functioning, and overall well-being in college students and young adults [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. Although the recommended sleep duration for individuals aged 18 to 25 years is 7 to 9 hours per night [<xref ref-type="bibr" rid="ref7">7</xref>], a study indicated that 30% to 50% of college students and young adults fail to meet this recommendation [<xref ref-type="bibr" rid="ref8">8</xref>].</p>
        <p>Short sleep duration is associated with numerous adverse outcomes in college students and young adults. These include poor dietary habits, obesity [<xref ref-type="bibr" rid="ref9">9</xref>], and an increased risk of mental health problems (eg, depression, suicidal behavior, and substance abuse) [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. Furthermore, insufficient sleep adversely affects academic performance and may lead to a need for prolonged years of study [<xref ref-type="bibr" rid="ref14">14</xref>]. Poor sleep in college students and young adults can also contribute to long-term sleep disturbances that may persist into adulthood [<xref ref-type="bibr" rid="ref15">15</xref>].</p>
        <p>Meta-analyses conducted by Friedrich and Schlarb [<xref ref-type="bibr" rid="ref16">16</xref>] and Saruhanjan et al [<xref ref-type="bibr" rid="ref17">17</xref>] have indicated that psychological interventions exert a substantial moderate-to-large effect on sleep-related outcomes in college students. In recent years, rapid technological advancements and the widespread adoption of electronic media have drawn attention to the relationship between electronic media use and sleep. A study indicated that college students and young adults spend an average of 316 minutes per week using electronic media, such as smartphones, tablets, emails, and video platforms [<xref ref-type="bibr" rid="ref18">18</xref>]. This demographic also engages with the internet more frequently than other age groups, rendering it a central aspect of their daily routines [<xref ref-type="bibr" rid="ref19">19</xref>]. Internet-based interventions have become a practical and promising solution to sleep problems, offering a form of therapy that individuals can access at their preferred time and location [<xref ref-type="bibr" rid="ref20">20</xref>]. Although face-to-face interventions are highly effective [<xref ref-type="bibr" rid="ref21">21</xref>], they are often costly, time-intensive, and impractical in many colleges or other settings [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. By contrast, electronic device–based interventions offer numerous advantages, including convenience, affordability, privacy, ease of distribution, and consistent content delivery [<xref ref-type="bibr" rid="ref24">24</xref>] These interventions have demonstrated comparable effectiveness to face-to-face methods in addressing sleep difficulties among college students and young adults [<xref ref-type="bibr" rid="ref17">17</xref>].</p>
        <p>Several studies have systematically reviewed the effectiveness of digital psychological interventions for college students [<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>]. However, these reviews did not specifically evaluate sleep-related outcomes. One review [<xref ref-type="bibr" rid="ref26">26</xref>] included only 2 studies on sleep, neither of which focused on sleep as a primary outcome, thereby limiting the specificity of the analysis regarding sleep-related interventions. Furthermore, the effects of electronic device–based sleep interventions on sleep outcomes in college students remain underexplored. In total, 4 systematic reviews have examined the effectiveness of digital cognitive behavioral therapy for insomnia (CBT-i) [<xref ref-type="bibr" rid="ref28">28</xref>-<xref ref-type="bibr" rid="ref31">31</xref>]. Among these reviews, 2 [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>] included college students. Tsai et al [<xref ref-type="bibr" rid="ref30">30</xref>] reviewed 4 studies, of which 1 included adolescents and 3 focused on college students. However, certain forms of digital CBT-i, such as interactive therapy and CBT-i delivered using mobile apps, were not analyzed, which considerably limits the applicability of their findings. In addition, Zhang et al [<xref ref-type="bibr" rid="ref31">31</xref>] analyzed digital sleep interventions in individuals aged 18 years and older with insomnia or poor sleep quality. Although the review included diverse populations, only 2 studies specifically focused on college students. The other 2 reviews [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>] focused on a broad range of participants aged 18 years and older, including adults and patients with sleep disorders. In addition, these reviews exclusively relied on subjective sleep outcome measures, not including objective data in their analyses [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Although these studies have provided strong evidence indicating improvements in sleep quality and insomnia symptoms, the heterogeneity in the characteristics of their participants may have affected the internal validity of their results, thereby limiting the generalizability of their findings.</p>
        <p>Research indicates that psychological interventions can substantially improve sleep quality and mental health in college students. However, the impact of digital interventions on sleep among college students and young adults remains underexplored. Given the high prevalence of sleep difficulties in this population and their widespread use of digital devices and mobile apps, investigating the effectiveness of digital sleep interventions is both relevant and crucial. This systematic review and meta-analysis focused on college students and young adults aged 18 to 25 years [<xref ref-type="bibr" rid="ref32">32</xref>]; this is a critical developmental stage often marked by poor sleep health [<xref ref-type="bibr" rid="ref33">33</xref>]. Importantly, this review addressed several limitations in literature by focusing solely on sleep-related outcomes in college students and young adults. Specifically, we examined both immediate and longer-term effects of digital sleep interventions on subjective and objective sleep measures. By including a wide variety of digital modalities, this review offers clearer insight into how technology-assisted sleep interventions can help improve sleep in this population.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>This systematic review and meta-analysis thus aimed to synthesize and quantitatively evaluate current evidence regarding the effectiveness of electronic device–based sleep interventions in enhancing sleep quality, reducing insomnia severity, and improving sleep outcomes among individuals aged 18 to 25 years, in comparison with control conditions.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>This systematic review and meta-analysis of randomized controlled trials (RCTs) investigated the effects of digital sleep interventions on college students and young adults aged 18 to 25 years. The included interventions were delivered via web-based platforms or mobile apps. The review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [<xref ref-type="bibr" rid="ref34">34</xref>], which are detailed in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. The review protocol was registered with PROSPERO (CRD42024595126).</p>
      </sec>
      <sec>
        <title>Data Sources and Search Strategy</title>
        <p>Two reviewers (YAL and HCL) worked collaboratively to conduct a comprehensive search across 5 electronic databases, namely PubMed, CINAHL, Cochrane Library, Embase, and Web of Science, to identify relevant studies published from each database’s inception to October 2024. The search strategy involved the use of the following keywords: “(college OR university AND students OR young adults) AND (digital OR sleep AND intervention OR internet OR web-based OR online OR email OR mobile OR smartphone OR virtual reality) AND (sleep OR sleep quality OR insomnia) AND (randomized controlled trial).” Details regarding the search strategies are provided in Table S1 in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. In addition, the reference lists of related articles were manually screened for further eligible studies. No restrictions regarding the language of publication were applied.</p>
      </sec>
      <sec>
        <title>Inclusion and Exclusion Criteria</title>
        <p>In this systematic review, we included RCTs that met the inclusion and exclusion criteria, as described in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>.</p>
        <boxed-text id="box1" position="float">
          <title>Inclusion and exclusion criteria.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Involved participants who were college or university students or young adults (aged 18-25 years, as defined by the Society for Adolescent Health and Medicine)</p>
            </list-item>
            <list-item>
              <p>Investigated the effects of sleep interventions delivered through electronic technologies, such as the internet, computers, tablets, mobile devices, telehealth, or virtual reality</p>
            </list-item>
            <list-item>
              <p>Included control groups comprising waiting-list control, placebo, no intervention, standard or usual care groups, or individuals receiving interventions delivered face-to-face through in-person coaching</p>
            </list-item>
            <list-item>
              <p>Assessed sleep outcomes of interest using either subjective measurements (eg, sleep questionnaires or sleep diaries) or objective measurements (eg, actigraphy)</p>
            </list-item>
            <list-item>
              <p>Reported both preintervention and postintervention outcome measures; no limitations regarding the language of publication were applied</p>
            </list-item>
          </list>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Involved participants who were prescribed medication for sleep</p>
            </list-item>
            <list-item>
              <p>Involved participants who had been clinically diagnosed with severe sleep disorder (eg, obstructive sleep apnea, parasomnias, and narcolepsy), based on diagnostic criteria from the <italic>Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition</italic>, and required more intensive treatment</p>
            </list-item>
            <list-item>
              <p>Involved participants who had psychiatric disorders (eg, major depressive disorder, bipolar disorder, or schizophrenia), diagnosed by a licensed clinician.</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Primary and Secondary Outcomes</title>
        <p>The primary outcomes of this review were sleep quality, sleep parameters and insomnia severity. The secondary outcomes included dysfunctional beliefs and attitudes about sleep, sleep hygiene, sleep knowledge, and presleep arousal in both cognitive and somatic domains.</p>
      </sec>
      <sec>
        <title>Study Selection and Data Extraction</title>
        <p>Duplicate articles were identified, removed, and screened using EndNote 20 (Clarivate) software. In total, 2 independent reviewers (YAL and HCL) screened the titles and abstracts of the remaining studies. Full-text reviews were conducted for studies meeting the inclusion criteria. Any disagreements between the 2 reviewers were resolved through discussion with a third reviewer (PST).</p>
        <p>Data were extracted using Microsoft Excel with a standardized form by 2 independent reviewers (YAL and HCL). Information on the following parameters was collected: study characteristics (eg, first author, publication year, country, number of participants, mean age, number of female participants, and history of insomnia); intervention type (eg, duration and delivery mode); postintervention dropout rates; use of intention-to-treat analysis; comparison groups; and outcome measurements (eg, sleep quality and sleep parameters). Study authors were contacted if any data were missing or incomplete. Available data were used when no response was received from corresponding authors.</p>
      </sec>
      <sec>
        <title>Assessment of Methodological Quality</title>
        <p>In total, 2 researchers (YAL and HCL) independently evaluated the quality of the included studies using the Cochrane Risk of Bias (version 2.0) tool for RCTs [<xref ref-type="bibr" rid="ref35">35</xref>]. This tool is used to evaluate bias across the following five domains: (1) bias arising from the randomization process, (2) bias due to deviations from the intended intervention, (3) bias due to missing outcome data, (4) bias in the measurement of the outcome, and (5) bias in the selection of reported results. The overall risk of bias was determined by synthesizing findings across these domains, and studies were categorized as having a low risk of bias, some concerns, or a high risk of bias. Discrepancies between the researchers were resolved through discussion or, if necessary, consultation with a third reviewer (PST).</p>
      </sec>
      <sec>
        <title>Data Synthesis and Analysis</title>
        <p>We conducted a meta-analysis of the pooled quantitative data using Comprehensive Meta-Analysis software (version 3.7; Biostat Inc). Effect sizes were calculated on the basis of reported means and SDs for each outcome. We analyzed preintervention to postintervention improvements and between-group differences in sleep-related outcomes. In addition, effect sizes for available follow-up measurements were calculated by comparing the intervention and control groups. A minimum of 2 studies per outcome was required to pool data for quantitative analyses.</p>
        <p>A random-effects model was applied to account for anticipated heterogeneity across studies. The primary effect size, Hedges <italic>g</italic> was calculated for continuous outcomes and reported with 95% CIs [<xref ref-type="bibr" rid="ref36">36</xref>]. Effect sizes were interpreted as small (0.2), moderate (0.5), or large (0.8) [<xref ref-type="bibr" rid="ref37">37</xref>]. Heterogeneity was assessed using the <italic>I</italic><sup>2</sup> statistic, with values of 0%, 25%, 50%, and 75% indicating no, low, moderate, and high heterogeneity, respectively [<xref ref-type="bibr" rid="ref38">38</xref>]. Substantial heterogeneity (ie, <italic>I</italic><sup>2</sup>≥50%) was explored through moderator analyses and meta-regression. For outcomes with high heterogeneity and significant effects, we performed moderator analyses (for categorical variables) and meta-regression (for continuous variables) to identify potential sources of heterogeneity. Moderator analyses were limited to subgroups represented in at least 2 studies. A <italic>P</italic> value of &#60;.05 was considered significant for both the moderator and the meta-regression analyses.</p>
        <p>To ensure the robustness of our findings, sensitivity analyses were conducted by excluding studies with a high risk of bias and evaluating their effects on the overall results. High-risk studies were defined as those with severe systematic biases, such as unclear reporting of the randomization process, deviations from intended interventions, missing outcome data, problems with outcome measurements, or selective reporting of results [<xref ref-type="bibr" rid="ref35">35</xref>]. Publication bias was assessed using Egger test and a funnel plot [<xref ref-type="bibr" rid="ref39">39</xref>]. For outcomes reported in at least 10 studies, the trim-and-fill method was applied to estimate the potential impact of missing studies [<xref ref-type="bibr" rid="ref40">40</xref>].</p>
      </sec>
      <sec>
        <title>Assessment of the Certainty of Evidence</title>
        <p>The quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations framework. The quality of evidence was categorized as high, moderate, low, or very low on the basis of a comprehensive assessment of several factors, including risk of bias, inconsistency, indirectness, imprecision, and other relevant considerations [<xref ref-type="bibr" rid="ref41">41</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Selection</title>
        <p>A total of 4699 records were identified through database searches, and 1572 duplicates were removed using EndNote 20. Two reviewers (YAL and HCL) independently dual-screened the titles and abstracts of the remaining studies. After the titles and abstracts were screened, 3093 records were deemed irrelevant and excluded. This process resulted in 34 studies being included for full-text review. Of these, 22 (65%) did not meet the inclusion criteria and were excluded from the systematic review. In addition, 1 study was identified through a manual search of reference lists in related articles. Finally, 13 (37%) studies were included in the meta-analysis [<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref54">54</xref>]. The study selection process is summarized in <xref rid="figure1" ref-type="fig">Figure 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram for study selection.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e69657_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Study Characteristics</title>
        <p>The included studies involved 5251 college students and young adults, with a mean age of 23.6 (SD 3.16) years and 69.55% (3652/5251) of participants being women. Most studies were conducted in the United States (n=6, 46%), followed by the United Kingdom (n=3, 23%), Asia (n=3, 23%) and the Middle East (n=1, 8%). The sample sizes ranged from 40 to 3755 participants. The average dropout rate was 17.7% in the intervention group and 12.6% in the control group. Nearly 74.73% (3924/5251) of the participants reported sleep problems at baseline. The diagnostic criteria for assessing sleep problems included the Insomnia Severity Index (ISI) in 2 studies [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>], the Sleep Condition Indicator (SCI) in 1 study [<xref ref-type="bibr" rid="ref44">44</xref>], and the Sleep Quality Score in 1 study [<xref ref-type="bibr" rid="ref49">49</xref>].</p>
        <p>Most (11/13, 85%) of the studies used a 2-arm trial design, whereas 2 studies adopted a 3-arm trial design [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. Jones et al [<xref ref-type="bibr" rid="ref48">48</xref>] compared “text message–based sleep intervention” with “placebo” and “no intervention.” In addition, Kim et al [<xref ref-type="bibr" rid="ref49">49</xref>] compared “virtual reality-based meditation” with “concentration meditation” and “no intervention.”</p>
        <p>The effectiveness of digital sleep interventions was evaluated in terms of various outcomes: 13 studies assessed subjective sleep quality, 5 (38%) examined objective sleep parameters, 4 (31%) evaluated insomnia severity, 2 (15%) focused on dysfunctional beliefs and attitudes about sleep, 4 (31%) assessed sleep hygiene, 3 (23%) evaluated sleep knowledge, and 2 (15%) analyzed presleep arousal. The instruments used to assess subjective sleep quality included the Pittsburgh Sleep Quality Index, the Korean Modified Leeds Evaluation Questionnaire, the Patient Reported Outcomes Measurement Information System, and sleep diaries. Objective sleep parameters were assessed using actigraphy. Insomnia severity was evaluated using the ISI or SCI. Dysfunctional beliefs and attitudes about sleep were measured using the Dysfunctional Beliefs and Attitudes about Sleep-16 scale. Sleep hygiene and knowledge were assessed using the Sleep Hygiene Index or the Sleep Hygiene Practice Scale. Presleep arousal was measured using the Pre-Sleep Arousal Scale. The details of the included studies are presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summary of characteristics of included studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="90"/>
            <col width="100"/>
            <col width="140"/>
            <col width="130"/>
            <col width="80"/>
            <col width="100"/>
            <col width="70"/>
            <col width="110"/>
            <col width="180"/>
            <thead>
              <tr valign="top">
                <td>Study, year, and country</td>
                <td>Number of participants</td>
                <td>Age (y), mean (SD)</td>
                <td>Women, n (%)</td>
                <td>History of insomnia</td>
                <td>Dropout (AI<sup>a</sup>), %</td>
                <td>Use of ITT<sup>b</sup></td>
                <td>Comparison</td>
                <td>Outcome measurements</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Barber and Cucalon [<xref ref-type="bibr" rid="ref42">42</xref>], 2017, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG<sup>c</sup>: 43</p>
                    </list-item>
                    <list-item>
                      <p>CG<sup>d</sup>: 35</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20.67 (2.52)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 20.33 (1.66)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 29 (37)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 18 (23)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 0</p>
                    </list-item>
                    <list-item>
                      <p>CG: 0</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>Passive (waiting list)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Actigraphy<sup>e</sup></p>
                    </list-item>
                    <list-item>
                      <p>SHI<sup>f</sup></p>
                    </list-item>
                    <list-item>
                      <p>Sleep quality</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Denis et al [<xref ref-type="bibr" rid="ref43">43</xref>], 2020, United Kingdom</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 99</p>
                    </list-item>
                    <list-item>
                      <p>CG: 100</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 19.73 (2.94)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 20.22 (5.69)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 99 (100)</p>
                    </list-item>
                    <list-item>
                      <p>CG:100 (100)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 32</p>
                    </list-item>
                    <list-item>
                      <p>CG: 22</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Active (puzzles)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>DBAS-16<sup>g</sup></p>
                    </list-item>
                    <list-item>
                      <p>MCQ<sup>h</sup></p>
                    </list-item>
                    <list-item>
                      <p>PSAS<sup>i</sup></p>
                    </list-item>
                    <list-item>
                      <p>PSQI<sup>j</sup></p>
                    </list-item>
                    <list-item>
                      <p>SCI<sup>k</sup></p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Freeman et al [<xref ref-type="bibr" rid="ref44">44</xref>], 2017, United Kingdom</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 1891</p>
                    </list-item>
                    <list-item>
                      <p>CG: 1864</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 24.83 (7.7)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 24.6 (7.6)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 1361 (72)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 1315 (71)</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 59.1</p>
                    </list-item>
                    <list-item>
                      <p>CG: 38.7</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Passive (usual practice)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>ISI<sup>l</sup></p>
                    </list-item>
                    <list-item>
                      <p>SCI</p>
                    </list-item>
                    <list-item>
                      <p>Sleep diaries</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Fucito et al [<xref ref-type="bibr" rid="ref45">45</xref>], 2017, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 21</p>
                    </list-item>
                    <list-item>
                      <p>CG: 21</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 24.83 (7.7)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 24.6 (7.6)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 10 (48)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 10 (48)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 9</p>
                    </list-item>
                    <list-item>
                      <p>CG: 9</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>Active (healthy behaviors)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Actigraphy<sup>e</sup></p>
                    </list-item>
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                    <list-item>
                      <p>PROMIS-SRI-SF<sup>m</sup></p>
                    </list-item>
                    <list-item>
                      <p>Sleep diaries</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Hershner and O’Brien [<xref ref-type="bibr" rid="ref46">46</xref>], 2018, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 254</p>
                    </list-item>
                    <list-item>
                      <p>CG: 295</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 21.9 (4.01)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 22 (4.35)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 140 (55.8)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 176 (60.5)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 42.9</p>
                    </list-item>
                    <list-item>
                      <p>CG: 30.2</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Passive (no intervention)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>ESS<sup>n</sup></p>
                    </list-item>
                    <list-item>
                      <p>MEQ<sup>o</sup></p>
                    </list-item>
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                    <list-item>
                      <p>SHI</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Huberty et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2019, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 56</p>
                    </list-item>
                    <list-item>
                      <p>CG: 53</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20.41 (2.31)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 21.85 (6.3)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 36 (41)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 43 (49)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 27</p>
                    </list-item>
                    <list-item>
                      <p>CG: 11</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Passive (waiting list)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>PROMIS<sup>p</sup></p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Jones et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2020, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 53</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 52</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 51</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 18.16 (0.37)</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 18.17 (0.38)</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 18.03 (0.17)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 38 (79)</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 29 (69)</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 36 (80)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 9</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 19</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 12</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>CG1: passive (Placebo);CG2: passive (no intervention)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                    <list-item>
                      <p>SHI</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2024, Korea</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 20</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 20</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 21.6 (1.47)</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 21.75 (1.48)</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 22.35 (1.35)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 15 (75)</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 13 (65)</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 13 (65)</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 0</p>
                    </list-item>
                    <list-item>
                      <p>CG1: 0</p>
                    </list-item>
                    <list-item>
                      <p>CG2: 0</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>CG1: active (Concentration meditation); CG2: passive (no intervention)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>KMLSEQ-LSEQ<sup>q</sup></p>
                    </list-item>
                    <list-item>
                      <p>Actigraphy<sup>e</sup></p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Liu et al [<xref ref-type="bibr" rid="ref50">50</xref>], 2024, Singapore</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 30</p>
                    </list-item>
                    <list-item>
                      <p>CG: 29</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 21.6 (4.26)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 22.4 (1.31)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 12 (40)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 9 (31)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 7</p>
                    </list-item>
                    <list-item>
                      <p>CG: 10</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Active (sleep QA<sup>r</sup> system)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Actigraphy<sup>e</sup></p>
                    </list-item>
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                    <list-item>
                      <p>Sleep diaries</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Morris et al [<xref ref-type="bibr" rid="ref51">51</xref>], 2016, United Kingdom</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 48</p>
                    </list-item>
                    <list-item>
                      <p>CG: 47</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20.69 (2.61)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 20.27 (1.56)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 29 (60)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 33 (70)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 25</p>
                    </list-item>
                    <list-item>
                      <p>CG: 6</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>Passive (waiting list)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Okajima et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2022, Japan</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 24</p>
                    </list-item>
                    <list-item>
                      <p>CG: 24</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG and CG: 19.56 (1.56)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 16 (67)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 16 (67)</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 12</p>
                    </list-item>
                    <list-item>
                      <p>CG: 17</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>Passive (self-monitoring)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>DBAS-16</p>
                    </list-item>
                    <list-item>
                      <p>FIRST<sup>s</sup></p>
                    </list-item>
                    <list-item>
                      <p>ISI</p>
                    </list-item>
                    <list-item>
                      <p>PSAS</p>
                    </list-item>
                    <list-item>
                      <p>SHPS<sup>t</sup></p>
                    </list-item>
                    <list-item>
                      <p>Sleep diaries</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Short and Schmidt [<xref ref-type="bibr" rid="ref53">53</xref>], 2020, United States</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 32</p>
                    </list-item>
                    <list-item>
                      <p>CG: 29</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG and CG: 19.43 (2.04)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG and CG: 51 (84.0)</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 6</p>
                    </list-item>
                    <list-item>
                      <p>CG: 10</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>Active (physical health education)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>ISI</p>
                    </list-item>
                    <list-item>
                      <p>SRBQ<sup>u</sup></p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Yıkılmaz et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2023, Turkey</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20</p>
                    </list-item>
                    <list-item>
                      <p>CG: 20</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 20.7 (1.21)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 21.05 (0.94)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 3 (15)</p>
                    </list-item>
                    <list-item>
                      <p>CG: 2 (10)</p>
                    </list-item>
                  </list>
                </td>
                <td>No</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>IG: 0</p>
                    </list-item>
                    <list-item>
                      <p>CG: 0</p>
                    </list-item>
                  </list>
                </td>
                <td>Yes</td>
                <td>Passive (no intervention)</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>PSQI</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>AI: after intervention.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>ITT: intention-to-treat analysis.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>IG: intervention group.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>CG: control group.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>Objective measures.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>SHI: Sleep Hygiene Index.</p>
            </fn>
            <fn id="table1fn7">
              <p><sup>g</sup>DBAS-16: Dysfunctional Beliefs And Attitudes About Sleep-16.</p>
            </fn>
            <fn id="table1fn8">
              <p><sup>h</sup>MCQ: Munich Chronotype Questionnaire</p>
            </fn>
            <fn id="table1fn9">
              <p><sup>I</sup>PSAS: Pre-Sleep Arousal Scale.</p>
            </fn>
            <fn id="table1fn10">
              <p><sup>j</sup>PSQI: Pittsburgh Sleep Quality Index.</p>
            </fn>
            <fn id="table1fn11">
              <p><sup>k</sup>SCI: Sleep Condition Indicator.</p>
            </fn>
            <fn id="table1fn12">
              <p><sup>l</sup>ISI: Insomnia Severity Index.</p>
            </fn>
            <fn id="table1fn13">
              <p><sup>m</sup>PROMIS-SRI-SF: Patient Reported Outcomes Measurement Information System Sleep-Related Impairment Short-Form.</p>
            </fn>
            <fn id="table1fn14">
              <p><sup>n</sup>ESS: Epworth Sleepiness Scale.</p>
            </fn>
            <fn id="table1fn15">
              <p><sup>o</sup>MEQ: Morningness-Eveningness Questionnaire.</p>
            </fn>
            <fn id="table1fn16">
              <p><sup>p</sup>PROMIS: Patient Reported Outcomes Measurement Information System.</p>
            </fn>
            <fn id="table1fn17">
              <p><sup>q</sup>KMLSEQ: Korean Modified Leeds Evaluation Questionnaire.</p>
            </fn>
            <fn id="table1fn18">
              <p><sup>r</sup>QA: question answering.</p>
            </fn>
            <fn id="table1fn19">
              <p><sup>s</sup>FIRST: Ford Insomnia Response to Stress Test.</p>
            </fn>
            <fn id="table1fn20">
              <p><sup>t</sup>SHPS: Sleep Hygiene Practice Scale.</p>
            </fn>
            <fn id="table1fn21">
              <p><sup>u</sup>SRBQ: Sleep-Related Behaviors Questionnaire.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Quality Assessments</title>
        <p>In total, 6 (46%) studies had a low overall risk of bias, 3 (23%) had a high overall risk of bias, and 4 (31%) had some concerns. Among the high-risk studies, 2 [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>] did not report their randomization methods. In addition, one of these studies [<xref ref-type="bibr" rid="ref46">46</xref>] had a high rate of missing data, compromising the integrity of the results because of its excessive data loss without explanation. Another study [<xref ref-type="bibr" rid="ref47">47</xref>] was classified as high risk because it explicitly stated that blinding of participants and assessors was not feasible.</p>
        <p>In total, 4 (31%) studies were categorized as having some concerns because of unclear information regarding specific domains. These included uncertainties about the randomization process [<xref ref-type="bibr" rid="ref44">44</xref>], blinding of participants [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>], and outcome measurement procedures [<xref ref-type="bibr" rid="ref49">49</xref>]. All studies demonstrated a low risk of bias concerning selective reporting, and none provided sufficient information to evaluate other potential sources of bias. The details of the risk of bias assessment are illustrated in <xref rid="figure2" ref-type="fig">Figure 2</xref> [<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref54">54</xref>].</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Risk of bias graph for included studies.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e69657_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Digital Sleep Interventions for College Students and Young Adults</title>
        <p>The components of the digital sleep interventions varied across the included studies. Among the 13 studies, 5 (38%) used CBT-i, 5 (38%) focused on sleep-related education or information, 2 (15%) incorporated meditation, and 1 (8%) used body awareness therapy. The intervention durations ranged from 5 days to 10 weeks, with 4 studies [<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref53">53</xref>] also assessing follow-up effects after the intervention period. Approximately half of the studies (n=7, 54%) were exclusively conducted in university settings. The detailed results are provided in <xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table2">2</xref>, and Table S1 in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref54">54</xref>].</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Summary of digital intervention features of included studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="190"/>
            <col width="360"/>
            <col width="250"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Study, year, and country</td>
                <td>Type</td>
                <td>Duration</td>
                <td>Mode of delivery</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Barber and Cucalon [<xref ref-type="bibr" rid="ref42">42</xref>], 2017, United States</td>
                <td>Sleep hygiene</td>
                <td>1 wk (22 min and 33 s)</td>
                <td>Web (through Microsoft PowerPoint)</td>
              </tr>
              <tr valign="top">
                <td>Denis et al [<xref ref-type="bibr" rid="ref43">43</xref>], 2020, United Kingdom</td>
                <td>Virtual therapist–led CBT-i<sup>a</sup> (cognitive techniques, relaxation techniques, sleep hygiene, sleep restriction, and stimulus control)</td>
                <td>6 wk (6 sessions per week, 20-25 min per session)</td>
                <td>Web (through a video platform)</td>
              </tr>
              <tr valign="top">
                <td>Freeman et al [<xref ref-type="bibr" rid="ref44">44</xref>], 2017, United Kingdom</td>
                <td>CBT-i (cognitive techniques, psychoeducation, relaxation techniques, sleep hygiene, sleep restriction, and stimulus control)</td>
                <td>10 wk (6 sessions, average of 20 min per session)</td>
                <td>Web</td>
              </tr>
              <tr valign="top">
                <td>Fucito et al [<xref ref-type="bibr" rid="ref45">45</xref>], 2017, United States</td>
                <td>CBT-i (cognitive techniques, psychoeducation, relaxation techniques, sleep hygiene, and stimulus control)</td>
                <td>4 wk (intervention consisted of 4 modules; 1 module per wk)</td>
                <td>Web</td>
              </tr>
              <tr valign="top">
                <td>Hershner and O’Brien [<xref ref-type="bibr" rid="ref46">46</xref>], 2018, United States</td>
                <td>Sleep education (a personality profile, 2 videos on sleep hygiene and its effects, and information on sleep behavior)</td>
                <td>8 wk (intervention consisted of sleep modules of 20 min)</td>
                <td>Web</td>
              </tr>
              <tr valign="top">
                <td>Huberty et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2019, United States</td>
                <td>Mindfulness meditation (body scan, breath focus, and kindness)</td>
                <td>8 wk (at least 10 min per session)</td>
                <td>Mobile app</td>
              </tr>
              <tr valign="top">
                <td>Jones et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2020, United States</td>
                <td>Health belief model education (theory based)</td>
                <td>6 wk (2 texts [first 2 wk]; 1 text [second 2 wk]; and 1 text every other day [final 2 wk])</td>
                <td>Online (through a text message)</td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2024, Korea</td>
                <td>Meditation (4 video types: sea, night sky, walking through a forest in the fall, and a green forest)</td>
                <td>5 d (30 min per d)</td>
                <td>VR<sup>b</sup> (through a video)</td>
              </tr>
              <tr valign="top">
                <td>Liu et al [<xref ref-type="bibr" rid="ref50">50</xref>], 2024, Singapore</td>
                <td>Sleep QA<sup>c</sup> system with health coaching</td>
                <td>4 wk (30 min per wk)</td>
                <td>Online (through text)</td>
              </tr>
              <tr valign="top">
                <td>Morris et al [<xref ref-type="bibr" rid="ref51">51</xref>], 2016, United Kingdom</td>
                <td>CBT-i (psychoeducation, relaxation techniques, sleep hygiene, sleep restriction, and stimulus control)</td>
                <td>6 wk (intervention consisted of 7 modules; 20 min per wk)</td>
                <td>Online (through text and email)</td>
              </tr>
              <tr valign="top">
                <td>Okajima et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2022, Japan</td>
                <td>CBT-i (cognitive techniques, relaxation techniques, sleep hygiene, sleep restriction, and stimulus control)</td>
                <td>8 wk (30 min per session; 8 sessions per wk)</td>
                <td>Online (through an email with PDF files)</td>
              </tr>
              <tr valign="top">
                <td>Short and Schmidt [<xref ref-type="bibr" rid="ref53">53</xref>], 2020, United States</td>
                <td>Motivation, psychoeducation, behavioral tools, and behavior change modules</td>
                <td>1 wk (intervention consisted of 4 modules of 45 min)</td>
                <td>Online (through text)</td>
              </tr>
              <tr valign="top">
                <td>Yıkılmaz et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2023, Turkey</td>
                <td>Physiotherapist-led, internet-based BBAT<sup>d</sup> intervention program</td>
                <td>6 wk (60 min per session; 3 sessions per wk)</td>
                <td>Videoconferencing</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>CBT-i: cognitive behavioral therapy for insomnia.</p>
            </fn>
            <fn id="table2fn2">
              <p><sup>b</sup>VR: virtual reality.</p>
            </fn>
            <fn id="table2fn3">
              <p><sup>c</sup>QA: question answering.</p>
            </fn>
            <fn id="table2fn4">
              <p><sup>d</sup>BBAT: basic body awareness therapy.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Comparators</title>
        <p>Most (n=10, 77%) of the included studies included a passive control group. In these studies, participants in the control group received usual or standard care, were placed on a waiting list, or did not receive any intervention. By contrast, the active control groups participated in sleep programs, received information on sleep education and healthy behaviors, or engaged in concentration meditation. The detailed results are provided in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
      </sec>
      <sec>
        <title>Effectiveness of Digital Sleep Interventions</title>
        <sec>
          <title>Sleep Quality</title>
          <p>The effects of digital sleep interventions on sleep quality were analyzed for both postintervention and follow-up periods. The pooled results revealed a large and significant postintervention effect (Hedges <italic>g</italic>=−1.25, 95% CI −1.83 to −0.66; <italic>P</italic>&#60;.001; <italic>I</italic><sup>2</sup>=97%) and a moderate but significant follow-up effect (Hedges <italic>g</italic>=−0.53, 95% CI −0.96 to −0.11; <italic>P</italic>=.01; <italic>I</italic><sup>2</sup>=78%). Substantial heterogeneity was observed between the studies. The detailed results are provided in <xref rid="figure3" ref-type="fig">Figure 3</xref> [<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref54">54</xref>].</p>
          <p>Although sleep quality is a critical outcome for college students and young adults, the certainty of evidence for the postintervention effects was rated as “low” (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). This rating was downgraded because of risks of bias, inconsistency, and imprecision but upgraded because of the large magnitude of the effect. For follow-up effects, the evidence was rated as having “moderate” certainty. These findings suggest that digital sleep interventions are likely to significantly improve sleep quality in both postintervention and follow-up assessments.</p>
          <fig id="figure3" position="float">
            <label>Figure 3</label>
            <caption>
              <p>Effect sizes for outcomes of interest (sleep quality) in studies evaluating digital sleep interventions. *Digital intervention compared to active control. **Digital intervention compared to passive control.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Sleep Parameters</title>
          <p>The pooled effects on sleep parameters, including sleep efficiency, total sleep time (TST), wake after sleep onset (WASO), and the number of awakenings (NWAK), were analyzed. Digital sleep interventions demonstrated a significant medium effect on sleep efficiency (Hedges <italic>g</italic>=0.62, 95% CI 0.18-1.05; <italic>P</italic>=.005; <italic>I</italic><sup>2</sup>=60%), with substantial heterogeneity among studies. However, nonsignificant effects were observed for NWAK (<italic>P</italic>=.27), TST (<italic>P</italic>=.07), and WASO (<italic>P</italic>=.18). The detailed results are provided in <xref rid="figure4" ref-type="fig">Figure 4</xref> [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>].</p>
          <p>Although sleep parameters are crucial outcomes, the certainty of the evidence ranged from “very low” to “low” (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). This low rating was because of increased risks of bias, inconsistency, and imprecision primarily resulting from variations in measurement methods for sleep parameters. Overall, the evidence remained highly uncertain regarding the postintervention effects of digital sleep interventions on sleep parameters.</p>
          <fig id="figure4" position="float">
            <label>Figure 4</label>
            <caption>
              <p>Effect sizes for outcomes of interest (sleep parameters) in studies evaluating digital sleep interventions. *Digital intervention compared to active control. **Digital intervention compared to passive control.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Insomnia Severity</title>
          <p>The pooled effects of digital sleep interventions on insomnia severity, as assessed using the ISI or SCI questionnaires, were analyzed for both postintervention and follow-up periods. The results indicated significant reductions in insomnia severity at postintervention (Hedges <italic>g</italic>=−4.08, 95% CI −5.14 to −3.02; <italic>P</italic>&#60;.001; <italic>I</italic><sup>2</sup>=99%) and follow-up assessments (Hedges <italic>g</italic>=−2.65, 95% CI −3.89 to −1.41; <italic>P</italic>&#60;.001; <italic>I</italic><sup>2</sup>=99%). Heterogeneity was observed in insomnia severity outcomes. The detailed results are provided in <xref rid="figure5" ref-type="fig">Figure 5</xref> [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>].</p>
          <p>Insomnia severity is a critical outcome, and the evidence supporting the postintervention and follow-up effects of digital sleep interventions was rated as having a “moderate” level of certainty (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). This rating was downgraded because of inconsistency and imprecision but was then upgraded because of the large magnitude of the observed effects. These findings suggest that digital sleep interventions are likely to significantly reduce insomnia severity in both postintervention and follow-up assessments.</p>
          <fig id="figure5" position="float">
            <label>Figure 5</label>
            <caption>
              <p>Effect sizes for outcomes of interest (insomnia severity) in studies evaluating digital sleep interventions. *Sleep Condition Indicator questionnaire. **Insomnia Severity Index questionnaire.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Dysfunctional Beliefs and Attitudes About Sleep</title>
          <p>The pooled results of 2 studies reporting the postintervention effects of digital sleep interventions on dysfunctional beliefs and attitudes about sleep indicated a large and significant effect (Hedges <italic>g</italic>=−2.11, 95% CI −3.33 to −0.97; <italic>P</italic>&#60;.001; <italic>I</italic><sup>2</sup>=86%). The detailed results are provided in <xref rid="figure6" ref-type="fig">Figure 6</xref> [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref52">52</xref>].</p>
          <p>The certainty of evidence for this outcome was rated as “low,” reflecting the limited importance of the Dysfunctional Beliefs and Attitudes About Sleep-16 as a measure (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). This rating was downgraded due to inconsistency and imprecision in the findings. Although the evidence suggested that digital sleep interventions moderately affected dysfunctional beliefs and attitudes about sleep in postintervention assessments, the clinical significance of this outcome remained uncertain.</p>
          <fig id="figure6" position="float">
            <label>Figure 6</label>
            <caption>
              <p>Effect sizes for outcomes of interest (dysfunctional beliefs and attitudes about sleep) in studies evaluating digital sleep interventions.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig6.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Sleep Hygiene</title>
          <p>Analysis of the pooled postintervention effects of digital sleep interventions on sleep hygiene revealed a small but significant improvement (Hedges <italic>g</italic>=−0.19, 95% CI −0.34 to −0.03; <italic>P</italic>=.02; <italic>I</italic><sup>2</sup>=0%). The detailed results are provided in <xref rid="figure7" ref-type="fig">Figure 7</xref> [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>].</p>
          <fig id="figure7" position="float">
            <label>Figure 7</label>
            <caption>
              <p>Effect sizes for outcomes of interest (sleep hygiene) in studies evaluating digital sleep interventions. *Digital intervention compared to active control. **Digital intervention compared to passive control.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig7.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>The evidence for this outcome was rated as having a “moderate” level of certainty, although sleep hygiene was considered an outcome of limited importance (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). The certainty rating was downgraded because of an increased risk of bias. These findings suggest that digital sleep interventions led to a slight improvement in sleep hygiene following the intervention.</p>
        </sec>
        <sec>
          <title>Sleep Knowledge</title>
          <p>The pooled results indicated a small but significant postintervention effect of digital sleep interventions on sleep knowledge (Hedges <italic>g</italic>=0.27, 95% CI 0.09-0.45; <italic>P</italic>=.003; <italic>I</italic><sup>2</sup>=0%). The detailed results are provided in <xref rid="figure8" ref-type="fig">Figure 8</xref> [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>].</p>
          <fig id="figure8" position="float">
            <label>Figure 8</label>
            <caption>
              <p>Effect sizes for outcomes of interest (sleep knowledge) in studies evaluating digital sleep interventions. *Digital intervention compared to active control. **Digital intervention compared to passive control.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig8.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>The evidence for this outcome was rated as having a “moderate” level of certainty, although sleep knowledge was considered an outcome of limited importance (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). The certainty rating was downgraded because of an increased risk of bias. These findings suggest that digital sleep interventions led to a slight improvement in sleep knowledge following the intervention.</p>
        </sec>
        <sec>
          <title>Presleep Arousal</title>
          <p>The effects of digital sleep interventions on presleep arousal, including cognitive and somatic domains, were analyzed. The pooled results indicated nonsignificant postintervention effects for both the cognitive domain (Hedges <italic>g</italic>=−2.02, 95% CI −5.86 to 1.82; <italic>P</italic>=.30; <italic>I</italic><sup>2</sup>=98%) and the somatic domain (Hedges <italic>g</italic>=−1.90, 95% CI −5.04 to 1.23; <italic>P</italic>=.23; <italic>I</italic><sup>2</sup>=98%). The detailed results are provided in <xref rid="figure9" ref-type="fig">Figure 9</xref> [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref52">52</xref>].</p>
          <fig id="figure9" position="float">
            <label>Figure 9</label>
            <caption>
              <p>Effect sizes for outcomes of interest (presleep arousal) in studies evaluating digital sleep interventions.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e69657_fig9.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <p>The certainty of evidence for these outcomes was rated as “low,” reflecting the limited importance of presleep arousal (cognitive and somatic domains) as a measure (Table S1 in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). The rating was downgraded because of inconsistency and imprecision in the findings. Overall, the evidence remained uncertain regarding the postintervention effects of digital sleep interventions on presleep arousal in both domains.</p>
        </sec>
      </sec>
      <sec>
        <title>Moderator Analysis</title>
        <p>Moderator analysis identified several significant sources of heterogeneity in the effects of digital sleep interventions on sleep quality. Key factors included the type of sleep assessment tool used (PSQI vs other questionnaires; <italic>P</italic>&#60;.001), intervention type (digital CBT-i vs other therapies; <italic>P</italic>&#60;.001), intervention duration (≤6 wk vs &#62;6 wk; <italic>P</italic>&#60;.001), therapist guidance (guided vs unguided; <italic>P</italic>&#60;.001), mode of delivery (email or text message vs video materials; <italic>P</italic>&#60;.01), history of insomnia (yes vs no; <italic>P</italic>&#60;.001), and the use of intention-to-treat analysis (yes vs no; <italic>P</italic>=.001).</p>
        <p>In addition, heterogeneity in insomnia severity outcomes, both after intervention (ISI vs SCI; <italic>P</italic>=.001) and at follow-up (ISI vs SCI; <italic>P</italic>&#60;.001), was primarily attributed to differences in the sleep assessment tool. Moreover, the variation in sleep efficiency was linked to intervention duration (1 vs 4 wk). The detailed results of the moderator (subgroup) analyses are provided in Table S1 in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>.</p>
      </sec>
      <sec>
        <title>Meta-Regression Analysis</title>
        <p>Meta-regression analyses indicated that neither mean age nor the percentage of women significantly contributed to heterogeneity in the effects of digital sleep interventions on various sleep-related outcomes (all <italic>P</italic>&#62;.05).</p>
        <p>Specifically, the effect size on sleep quality was not significantly associated with mean age (β=−.18, 95% CI −0.46 to 0.11; <italic>P</italic>=.23) or the percentage of women (β=.002, 95% CI −0.03 to 0.03; <italic>P</italic>=.90). Similarly, sleep efficiency was not significantly influenced by mean age (β=.06, 95% CI −0.55 to 0.68; <italic>P</italic>=.85) or the percentage of women (β=.003, 95% CI −0.04 to 0.04; <italic>P</italic>=.90).</p>
        <p>The effect size on WASO also showed no significant association with mean age (β=−1.18, 95% CI −6.30 to 3.94; <italic>P</italic>=.65) or the percentage of women (β=−.02, 95% CI −.05 to .01; <italic>P</italic>=.12).</p>
        <p>Similarly, insomnia severity, both after intervention and at follow-up, was not significantly associated with mean age (β=.31, 95% CI −0.39 to 1.01; <italic>P</italic>=.39 and β=.02, 95% CI −0.36 to 0.40; <italic>P</italic>=.90, respectively). The percentage of women also showed no significant association with insomnia severity postintervention (β=.13, 95% CI −0.02 to 0.27; <italic>P</italic>=.09) or at follow-up (β=.01, 95% CI −0.07 to 0.09; <italic>P</italic>=.85).</p>
        <p>Finally, sleep efficiency was not significantly associated with mean age (β=−.03, 95% CI −0.15 to 0.08; <italic>P</italic>=.54) or the percentage of women (β=.01, 95% CI −0.02 to 0.04; <italic>P</italic>=.39).</p>
      </sec>
      <sec>
        <title>Sensitivity Analysis</title>
        <p>Sensitivity analyses were conducted to assess the robustness of the findings of the meta-analysis. Exclusion of the data of 3 high-risk studies from the pooled data on sleep quality had a minimal impact on the results (<italic>P</italic>&#60;.001), despite the substantial heterogeneity observed in postintervention sleep quality (<italic>I</italic><sup>2</sup>=97%). In addition, a sensitivity analysis in which the data of one high-risk study were excluded from the pooled data on SE for sleep parameters revealed negligible changes in the results (<italic>P</italic>=.004), further supporting the robustness of the findings. The detailed results are provided in Table S2 in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>.</p>
      </sec>
      <sec>
        <title>Publication Bias</title>
        <p>Publication bias for sleep quality was assessed using the Egger test and a funnel plot. The Egger test indicated no significant publication bias (<italic>P</italic>=.24). The funnel plot is presented in <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref>.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Overview</title>
        <p>This systematic review and meta-analysis evaluated the effects of digital sleep interventions on sleep-related outcomes in college students and young adults (aged 18 to 25 years). The findings demonstrate that digital sleep interventions significantly improved sleep quality, sleep efficiency as a sleep parameter, insomnia severity, dysfunctional beliefs and attitudes about sleep, sleep hygiene, and sleep knowledge. These results indicate the value of evidence-based digital sleep interventions for addressing sleep problems in this population.</p>
      </sec>
      <sec>
        <title>Sleep Quality and Insomnia Severity</title>
        <p>Our results are consistent with those of previous studies [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref31">31</xref>] demonstrating that digital sleep interventions effectively alleviate sleep disturbances. Reviews have reported moderate-to-large effect sizes for improvements in sleep quality and reductions in insomnia severity. These results are particularly relevant given the high prevalence of poor sleep quality and insomnia among college students and young adults [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Digital interventions offer accessible and scalable solutions for managing sleep problems. This review noted that the beneficial effects of digital sleep interventions on sleep quality were sustained for 3 to 6 weeks after intervention, whereas improvements in insomnia severity persisted for up to 1 to 6 months. These findings highlight the potential of digital sleep interventions as a sustainable and effective treatment option for this demographic.</p>
      </sec>
      <sec>
        <title>Sleep Parameters</title>
        <p>Digital sleep interventions significantly improved sleep efficiency but demonstrated limited effects on other sleep parameters. These findings are in line with those reported by Maurer et al [<xref ref-type="bibr" rid="ref57">57</xref>] who examined the impact of digital CBT-i on sleep parameters in individuals with insomnia disorder. The observed improvements in sleep efficiency suggest that digital interventions can meaningfully enhance the proportion of time spent asleep while in bed. However, no significant effects were found for other objective measures, such as NWAK, TST, and WASO. This lack of consistency may be attributable to the variability in the methods used to measure sleep parameters across studies, which could have affected the outcomes [<xref ref-type="bibr" rid="ref58">58</xref>]. Future research should prioritize standardizing sleep measures to improve consistency and reliability.</p>
      </sec>
      <sec>
        <title>Dysfunctional Beliefs and Attitudes About Sleep</title>
        <p>Digital interventions effectively reduced dysfunctional beliefs and attitudes about sleep, consistent with findings reported by Thakral et al [<xref ref-type="bibr" rid="ref59">59</xref>], who indicated the effectiveness of CBT-i in helping individuals develop healthier sleep-related beliefs and attitudes. However, this result contrasts with that reported by Linardon et al [<xref ref-type="bibr" rid="ref60">60</xref>], whose meta-analysis found that smartphone app-based interventions for insomnia and sleep disturbances did not effectively reduce dysfunctional beliefs and attitudes about sleep. A potential explanation for this discrepancy is that the intervention in the study by Linardon et al [<xref ref-type="bibr" rid="ref60">60</xref>] did not specifically address participants’ individual sleep-related beliefs and attitudes, which may have reduced the persuasiveness and impact of the CBT-i components. Our findings highlight the critical role of CBT-i as a core element in digital sleep interventions, given its demonstrated effectiveness in improving dysfunctional beliefs and attitudes about sleep outcomes [<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>].</p>
      </sec>
      <sec>
        <title>Sleep Hygiene and Sleep Knowledge</title>
        <p>Although the improvements in sleep hygiene and sleep knowledge were smaller than those for other outcomes, they remain significant. This is consistent with findings reported by Bauducco et al [<xref ref-type="bibr" rid="ref64">64</xref>] and Inhulsen et al [<xref ref-type="bibr" rid="ref65">65</xref>] and by Chehri et al [<xref ref-type="bibr" rid="ref66">66</xref>] who demonstrated that sleep hygiene practices are closely linked to sleep quality [<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>]. Promoting better sleep hygiene and increasing awareness of healthy sleep habits are essential strategies for addressing sleep problems. Sleep-related education that promotes knowledge and encourages behavioral changes is particularly effective at addressing sleep problems [<xref ref-type="bibr" rid="ref67">67</xref>]. Such initiatives are especially valuable for raising awareness and establishing healthier sleep routines among college students and young adults (aged 18-25 years).</p>
      </sec>
      <sec>
        <title>Presleep Arousal</title>
        <p>The effect sizes for Pre-Sleep Arousal Scale scores related to presleep arousal in both cognitive and somatic domains were nonsignificant, likely because the number of eligible RCTs was limited. Presleep arousal is a known predisposing factor for insomnia, with high levels in either domain commonly observed in individuals with sleep disorders, which considerably interferes with the ability to fall asleep [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. Future interventions should incorporate additional components, such as mindfulness or relaxation techniques, to more effectively address this aspect of sleep disruption.</p>
      </sec>
      <sec>
        <title>Moderator</title>
        <p>Moderator (subgroup) analyses revealed that digital CBT-i had greater effects on improving sleep quality than other digital sleep interventions, and therapist-guided interventions outperformed unguided ones. These findings suggest that therapist-guided digital CBT-i is a particularly effective approach to managing sleep problems [<xref ref-type="bibr" rid="ref28">28</xref>]. Unlike the review by Hasan et al [<xref ref-type="bibr" rid="ref28">28</xref>], which focused on general population, we incorporated both subjective and objective sleep data and specifically targeted college students and young adults. This focused approach provided deeper insights into the effectiveness of therapist-guided digital CBT-i in improving sleep outcomes for this population.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>To the best of our knowledge, this study is the first to comprehensively investigate the effects of various digital sleep interventions on sleep parameters among college students and young adults. By examining multiple sleep-related outcomes, we provided a holistic understanding of how digital interventions affect different aspects of sleep. However, several limitations of this study should be acknowledged. First, significant heterogeneity was observed across the studies due to variations in intervention regimens and outcome measures, which likely contributed to the inconsistencies in the results. Second, the inclusion of studies with a high risk of bias may have reduced the overall quality of evidence and affected the validity of the findings. However, sensitivity analyses in which high-risk studies were excluded revealed no significant changes in the outcomes, reinforcing the reliability of the results. Third, most studies relied heavily on self-reported measures, which are prone to biases, and objective assessments were underutilized. Finally, the lack of long-term follow-up data in many of the studies limited our ability to provide insights into the sustained impact of these interventions over time.</p>
      </sec>
      <sec>
        <title>Relevance for Implementation</title>
        <p>We obtained robust evidence indicating that digital sleep interventions are an effective approach to addressing a variety of sleep problems among college students and young adults. These interventions offer a convenient and accessible method for managing sleep disturbances, serving as a low-intensity, cost-effective alternative for individuals who cannot or prefer not to access traditional sleep treatments. By helping users develop effective sleep-related skills, digital interventions can significantly improve sleep outcomes in this population. However, further research is required to enhance their effectiveness. Personalized digital tools that tailor interventions to individuals’ specific sleep patterns and behaviors should be explored. In addition, future RCTs should compare the effectiveness of guided versus unguided digital CBT-i, as therapist involvement may possibly exert attention effects and improve treatment adherence. Future research could benefit from incorporating qualitative approaches to gain deeper insight into user experiences with digital sleep interventions. In addition, combining both subjective and objective measures, such as actigraphy, would offer a more comprehensive evaluation of the interventions’ effectiveness. Longer follow-up periods are also required to enable assessment of the durability of intervention effects, ensuring these tools optimize their potential to improve sleep outcomes for college students and young adults.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This review provides up-to-date evidence on the effectiveness of digital sleep interventions in improving various sleep-related outcomes among college students and young adults. According to the Grading of Recommendations Assessment, Development, and Evaluations assessment, the certainty of evidence ranged from moderate to very low. Specifically, moderate certainty was found for sleep quality, insomnia severity, sleep hygiene, and sleep knowledge, while other outcomes had low or very low certainty.</p>
        <p>We conclude that digital sleep interventions can improve overall perceived sleep quality and insomnia severity in both postintervention and follow-up assessments. They may also have a slight impact on dysfunctional beliefs and attitudes about sleep, sleep hygiene, and sleep knowledge in postintervention assessments. However, the evidence remains highly uncertain regarding their effects on sleep parameters and somewhat uncertain concerning their impact on presleep arousal in both cognitive and somatic domains. These findings may be influenced by high heterogeneity, variations in interventions and outcome measures, reliance on self-reported data, and the absence of long-term follow-up, which limits the ability to assess the sustained effects of digital sleep interventions. Future research should aim to address these limitations to improve the applicability and effectiveness of digital sleep interventions.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist.</p>
        <media xlink:href="jmir_v27i1e69657_app1.docx" xlink:title="DOCX File , 37 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Literature search strategy.</p>
        <media xlink:href="jmir_v27i1e69657_app2.docx" xlink:title="DOCX File , 27 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Detailed description of digital sleep interventions based on the Template for Intervention Description and Replication (TiDIER) checklist.</p>
        <media xlink:href="jmir_v27i1e69657_app3.docx" xlink:title="DOCX File , 31 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Grading of Recommendations Assessment, Development, and Evaluation (GRADE) summary.</p>
        <media xlink:href="jmir_v27i1e69657_app4.docx" xlink:title="DOCX File , 30 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Summary of moderator analysis and sensitivity analyses.</p>
        <media xlink:href="jmir_v27i1e69657_app5.docx" xlink:title="DOCX File , 40 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Funnel plot for publication bias.</p>
        <media xlink:href="jmir_v27i1e69657_app6.docx" xlink:title="DOCX File , 78 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CBT-i</term>
          <def>
            <p>cognitive behavioral therapy for insomnia</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">ISI</term>
          <def>
            <p>Insomnia Severity Index</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">NWAK</term>
          <def>
            <p>number of awakenings</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">SCI</term>
          <def>
            <p>Sleep Condition Indicator</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">TST</term>
          <def>
            <p>total sleep time</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">WASO</term>
          <def>
            <p>wake after sleep onset</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The datasets generated or analyzed during this study are available from the corresponding author on reasonable request</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>YAL contributed to writing-original draft, visualization, methodology, software, formal analysis, data curation, and conceptualization. HCL contributed to writing (review and editing), validation, software, and data curation. PST contributed to writing (review and editing), validation, supervision, and conceptualization. All authors have read and agreed to the published version of the manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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