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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e65269</article-id>
      <article-id pub-id-type="pmid">40153796</article-id>
      <article-id pub-id-type="doi">10.2196/65269</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Factors Influencing Health Care Technology Acceptance in Older Adults Based on the Technology Acceptance Model and the Unified Theory of Acceptance and Use of Technology: Meta-Analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Moradi</surname>
            <given-names>Elahe</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Schomakers</surname>
            <given-names>Eva-Maria</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Meister</surname>
            <given-names>Sven</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Yang</surname>
            <given-names>Hyo Jun</given-names>
          </name>
          <degrees>BA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0004-0835-3932</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>Ji-Hyun</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9560-4285</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>Wonjae</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Graduate School of Culture Technology</institution>
            <institution>Korea Advanced Institute of Science and Technology</institution>
            <addr-line>291 Daehak-ro, Yuseong District</addr-line>
            <addr-line>Daejeon, 34141</addr-line>
            <country>Republic of Korea</country>
            <phone>82 010 7341 4441</phone>
            <email>wnjlee@kaist.ac.kr</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9584-2101</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Graduate School of Culture Technology</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Wonjae Lee <email>wnjlee@kaist.ac.kr</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>28</day>
        <month>3</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e65269</elocation-id>
      <history>
        <date date-type="received">
          <day>14</day>
          <month>8</month>
          <year>2024</year>
        </date>
        <date date-type="rev-request">
          <day>12</day>
          <month>1</month>
          <year>2025</year>
        </date>
        <date date-type="rev-recd">
          <day>24</day>
          <month>1</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>25</day>
          <month>2</month>
          <year>2025</year>
        </date>
      </history>
      <copyright-statement>©Hyo Jun Yang, Ji-Hyun Lee, Wonjae Lee. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.03.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e65269" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The technology acceptance model (TAM) and the unified theory of acceptance and use of technology (UTAUT) are widely used to examine health care technology acceptance among older adults. However, existing literature exhibits considerable heterogeneity, making it difficult to determine consistent predictors of acceptance and behavior.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>We aimed to (1) determine the influence of perceived usefulness (PU), perceived ease of use (PEOU), and social influence (SI) on the behavioral intention (BI) to use health care technology among older adults and (2) assess the moderating effects of age, gender, geographic region, type of health care technology, and presence of visual demonstrations.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A systematic search was conducted across Google Scholar, Web of Science, Scopus, IEEE Xplore, and ProQuest databases on March 15, 2024, following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Of the 1167 initially identified studies, 41 studies (11,574 participants; mean age 67.58, SD 4.76 years; and female:male ratio=2.00) met the inclusion criteria. The studies comprised 12 mobile health, 12 online or telemedicine, 9 wearable, and 8 home or institution hardware investigations, with 23 studies from Asia, 7 from Europe, 7 from African-Islamic regions, and 4 from the United States. Studies were eligible if they used the TAM or UTAUT, examined health care technology adoption among older adults, and reported zero-order correlations. Two independent reviewers screened studies, extracted data, and assessed methodological quality using the Newcastle-Ottawa Scale, evaluating selection, comparability, and outcome assessment with 34% (14/41) of studies rated as <italic>good</italic> quality and 66% (27/41) as <italic>satisfactory</italic>.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Random-effects meta-analysis revealed significant positive correlations for PU-BI (<italic>r</italic>=0.607, 95% CI 0.543-0.665; <italic>P</italic>&#60;.001), PEOU-BI (<italic>r</italic>=0.525, 95% CI 0.462-0.583; <italic>P</italic>&#60;.001), and SI-BI (<italic>r</italic>=0.551, 95% CI 0.468-0.624; <italic>P</italic>&#60;.001). High heterogeneity was observed across studies (<italic>I</italic>²=95.9%, 93.6%, and 95.3% for PU-BI, PEOU-BI, and SI-BI, respectively). Moderator analyses revealed significant differences based on geographic region for PEOU-BI (<italic>Q</italic>=8.27; <italic>P</italic>=.04), with strongest effects in Europe (<italic>r</italic>=0.628) and weakest in African-Islamic regions (<italic>r</italic>=0.480). Technology type significantly moderated PU-BI (<italic>Q</italic>=8.08; <italic>P</italic>=.04) and SI-BI (<italic>Q</italic>=14.75; <italic>P</italic>=.002), with home or institutional hardware showing the strongest effects (PU-BI: <italic>r</italic>=0.736; SI-BI: <italic>r</italic>=0.690). Visual demonstrations significantly enhanced PU-BI (<italic>r</italic>=0.706 vs <italic>r</italic>=0.554; <italic>Q</italic>=4.24; <italic>P</italic>=.04) and SI-BI relationships (<italic>r</italic>=0.670 vs <italic>r</italic>=0.492; <italic>Q</italic>=4.38; <italic>P</italic>=.04). Age and gender showed no significant moderating effects.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The findings indicate that PU, PEOU, and SI significantly impact the acceptance of health care technology among older adults, with heterogeneity influenced by geographic region, type of technology, and presence of visual demonstrations. This suggests that tailored strategies for different types of technology and the use of visual demonstrations are important for enhancing adoption rates. Limitations include varying definitions of <italic>older adults</italic> across studies and the use of correlation coefficients rather than controlled effect sizes. Results should therefore be interpreted within specific contexts and populations.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>technology adoption</kwd>
        <kwd>older adults</kwd>
        <kwd>health care technology</kwd>
        <kwd>technology acceptance model</kwd>
        <kwd>unified theory of acceptance and use of technology</kwd>
        <kwd>meta-analysis</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>According to the United Nations, the number of people aged ≥65 years is projected to be 1.6 billion in 2050, which is double of what it was in 2021 [<xref ref-type="bibr" rid="ref1">1</xref>], and the number of persons aged ≥80 years is projected to be 143 million in 2050, triple of what it was in 2019 [<xref ref-type="bibr" rid="ref2">2</xref>]. This demographic shift raises significant concerns for the escalating burden on health care systems and associated financial implications. Advanced age is often associated with a higher prevalence of chronic illnesses and age-related conditions, necessitating increased medical attention and resources [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>].</p>
        <p>Technology can play a role in supporting older adults in health care by allowing quicker information and communication, preventing the development of chronic conditions, and monitoring health conditions [<xref ref-type="bibr" rid="ref5">5</xref>]. At the same time, they can also reduce caregiver burden, leading to cheaper and better-quality care [<xref ref-type="bibr" rid="ref6">6</xref>]. However, despite the potential benefits offered by these advancements, their widespread adoption remains limited, primarily due to ambivalence among older adults toward technology acceptance [<xref ref-type="bibr" rid="ref7">7</xref>]. Therefore, identifying the factors that affect the acceptance of technology for older adults is one of the most important research needs to support older adults’ use of technology [<xref ref-type="bibr" rid="ref8">8</xref>].</p>
        <p>However, a key issue is that the current literature that aims to understand the acceptance of health care technology for older adults exhibits significant heterogeneity, with diverse studies yielding varying effects and strengths of predictors [<xref ref-type="bibr" rid="ref9">9</xref>]. To explain, the technology acceptance model (TAM) [<xref ref-type="bibr" rid="ref10">10</xref>] and the unified theory of acceptance and use of technology (UTAUT) [<xref ref-type="bibr" rid="ref11">11</xref>] are commonly used by scholars to understand technology in the context of health [<xref ref-type="bibr" rid="ref12">12</xref>] and were applied in research of different types of health care technology and their acceptance by older adults [<xref ref-type="bibr" rid="ref13">13</xref>-<xref ref-type="bibr" rid="ref15">15</xref>]. TAM uses perceived usefulness (PU) and perceived ease of use (PEOU), with the subsequent TAM2 adding subjective norm, while UTAUT identifies performance expectancy (PE), effort expectancy (EE), social influence (SI), and facilitating conditions as core determinants to explain behavioral intention (BI). The constructs of TAM and UTAUT can be combined due to their conceptual similarities and complementary nature and previous studies have used the findings of both models in meta-analysis [<xref ref-type="bibr" rid="ref16">16</xref>]. PU and PE both reflect the belief that using technology will enhance performance, while PEOU and EE indicate the perceived effort required to use the technology. SI, akin to subjective norm in TAM2, addresses the influence of other important factors on technology use. Both models use the constructs to explain BI, the intention to adopt technology.</p>
        <p>To elaborate the heterogeneity of the TAM and UTAUT literature, studies have shown that older adults are more likely to accept technology that meets their needs and expectations [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. However, the impact of PU on technology acceptance varies for health care technology. Li et al [<xref ref-type="bibr" rid="ref19">19</xref>] found that PU had very little impact on the BI to adopt a remote health management service for older adults while Mahmood and Lee [<xref ref-type="bibr" rid="ref20">20</xref>] reported a high influence of PU for health monitoring wearable technology. For older adults, ease of use is crucial because physical and cognitive abilities affect the acceptance and use of technology [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. However, studies are conflicting. Wu et al [<xref ref-type="bibr" rid="ref23">23</xref>] identified a high effect for the acceptance of medical self-service terminals, but Khan et al [<xref ref-type="bibr" rid="ref24">24</xref>] observed a low effect for mobile health (mHealth) services. Similarly, for SI, while it is understood SI can significantly affect older adults’ technology adoption, particularly those from their children, friends, and professional caregivers [<xref ref-type="bibr" rid="ref25">25</xref>], heterogeneity exists in the current literature. Koo et al [<xref ref-type="bibr" rid="ref26">26</xref>] detected a high effect of SI for the acceptance of a personalized health care service app while Wong et al [<xref ref-type="bibr" rid="ref27">27</xref>] determined that SI had no effect on the use of the internet for health information in one of the 2 models used in the study.</p>
        <p>Such heterogeneity makes it difficult to interpret results because the inconsistent findings across studies prevent a clear, unified understanding of the effects of PU, PEOU, and SI on BI for health care technology acceptance among older adults. This study aimed to perform a meta-analysis to systematically aggregate and analyze these diverse results, providing a more robust and comprehensive assessment of the factors influencing health care technology adoption in this population and the characteristics of the primary studies that have moderating effects. Similar research, such as the quantitative meta-analysis by Chong et al [<xref ref-type="bibr" rid="ref16">16</xref>], provided an expansive study into the TAM and UTAUT literature on health care information technologies but did not focus on older adults and was limited to a specific type of health care technology, while Ma et al [<xref ref-type="bibr" rid="ref28">28</xref>] focused on literature that applied the 2 models for older adults without specifying the type of technology. Therefore, a meta-analysis that specifically targets older adults and their acceptance of different types of health care technology is needed to provide a more defined analysis of the current literature.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>To ensure a clearer interpretation of the current literature regarding the acceptance of health care technology for older adults, this study aimed to (1) synthesize the sample size–weighted average of the PU-BI, PEOU-BI, and SI-BI relationships for the current literature that used TAM or UTAUT to examine the acceptance of health care technology for older adults and (2) identify sources of systematic heterogeneity by analyzing the sample and methodology characteristics of the primary studies that moderate the PU-BI, PEOU-BI, and SI-BI relationships.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Literature Search</title>
        <p>While traditional systematic review frameworks such as patient, intervention, comparison, and outcome or sample, phenomenon of interest, design, evaluation, research type were considered, these structures did not optimally align with our research focus on technology acceptance behavior, particularly as elements such as interventions or comparisons were not directly applicable to our context. Instead, we developed a focused search strategy specifically designed to capture studies examining TAM, UTAUT, and their associated constructs in the context of older adults’ health care technology acceptance.</p>
        <p>The systematic search was conducted in 5 databases (Google Scholar, Web of Science, Scopus, IEEE Xplore, and ProQuest) on March 15, 2024. Google Scholar was included for its ability to capture a broad range of interdisciplinary studies beyond purely clinical research, aligning with the scope of this study. While we initially searched PubMed as it is a prioritized database for clinical studies, it yielded fewer relevant results, leading us to expand our search to additional databases. Testing confirmed that the PubMed results were already captured by the selected databases, affirming the adequacy of our chosen sources.</p>
        <p>A combination of 3 groups of word strings was developed using logical operators (AND/OR) as follows: (1) age-related keywords: <italic>older adult</italic> OR <italic>elderly</italic> OR <italic>ageing</italic> OR <italic>aging</italic>, (2) theoretical framework keywords: <italic>unified theory of acceptance and use of technology</italic> OR <italic>UTAUT</italic> OR <italic>technology acceptance model</italic> OR <italic>TAM</italic> OR <italic>acceptance</italic> OR <italic>adoption</italic> OR <italic>intention</italic>, and (3) context of use keywords: <italic>health</italic> OR <italic>healthcare</italic> OR <italic>well-being</italic> OR <italic>gerontechnology.</italic></p>
        <p>The search terms were collaboratively developed by 3 reviewers (HJY, JHL, and WJL) and refined through iterative rapid searches across the selected databases. These rapid searches were conducted to evaluate the effectiveness of the search terms, ensuring they comprehensively captured relevant studies while minimizing irrelevant results. The final search terms were chosen to align with the study’s focus on TAM and UTAUT frameworks for health care technology acceptance among older adults. The full search terms and detailed search strategy are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendices 1</xref> and <xref ref-type="supplementary-material" rid="app2">2</xref>. The number of articles identified, screened, eligible, and included were recorded according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>).</p>
      </sec>
      <sec>
        <title>Eligibility Criteria</title>
        <p>In total, 2 reviewers independently screened the titles and abstracts to identify studies eligible for full-text screening and subsequently conducted the full-text screening of the selected studies. Any disagreements during this process were resolved through a majority vote, with input from a third researcher to ensure consensus. To ensure that the selected studies were directly relevant to the research question, a rigorous inclusion criteria were applied during the full-text screening as described in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>.</p>
        <boxed-text id="box1" position="float">
          <title>Inclusion and exclusion criteria for meta-analysis of health care technology acceptance for older adults.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Article type: peer-reviewed journal articles, conference papers, and dissertations</p>
            </list-item>
            <list-item>
              <p>Language: English-language publications</p>
            </list-item>
            <list-item>
              <p>Theoretical framework: studies using technology acceptance model (including perceived usefulness [PU] and perceived ease of use [PEOU]) or the unified theory of acceptance and use of technology (including performance expectancy and effort expectancy)</p>
            </list-item>
            <list-item>
              <p>Technology context: studies focusing on health care technology, including mobile health, wearable devices, telemedicine, and home-based health care systems</p>
            </list-item>
            <list-item>
              <p>Study population: older adults (generally aged ≥50 years) or studies explicitly targeting older populations</p>
            </list-item>
            <list-item>
              <p>Outcome measures: studies reporting zero-order correlations between PU-behavioral intention (BI), PEOU-BI, and social influence-BI, or similar constructs</p>
            </list-item>
            <list-item>
              <p>Study characteristics: studies with a single, clearly defined characteristic, such as one geographic region or one technology type</p>
            </list-item>
          </list>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Article type: editorials, opinion pieces, book chapters, and nonpeer-reviewed sources</p>
            </list-item>
            <list-item>
              <p>Language: non-English publications</p>
            </list-item>
            <list-item>
              <p>Theoretical framework: studies that do not use technology acceptance model or the unified theory of acceptance and use of technology as the primary theoretical framework</p>
            </list-item>
            <list-item>
              <p>Technology context: studies examining non–health care–related technologies or general technology acceptance without health care relevance</p>
            </list-item>
            <list-item>
              <p>Study population: studies that do not specify an older adult population or focus on general populations</p>
            </list-item>
            <list-item>
              <p>Outcome measures: studies that do not provide statistical correlation data relevant to the analysis</p>
            </list-item>
            <list-item>
              <p>Study characteristics: studies that mix multiple regions or technology types without providing separate analyses</p>
            </list-item>
          </list>
        </boxed-text>
        <p>If a study’s sample included 2 or more of the same characteristics (eg, participants from both Asia and Europe and survey regarding multiple types of technology), it was not included. Theses and dissertations were involved as well to reduce the chance of publication bias. If a study met the criteria but did not report the zero-order correlations, an email was sent to the corresponding author to request the information. The inclusion and exclusion criteria are shown in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>.</p>
      </sec>
      <sec>
        <title>Data Extraction</title>
        <p>The coding procedure for the primary studies’ characteristics was designed to ensure the extraction of the required data. The 2 researchers separately extracted the information of the primary studies into a Microsoft Excel spreadsheet. If any disagreements arose, the third researcher, who is an experienced statistician, was involved for a resolution. The following information was coded:</p>
        <list list-type="order">
          <list-item>
            <p>Required data, including the author’s name, publication year, sample size, and correlation coefficient of PU-BI, PEOU-BI, and SI-BI</p>
          </list-item>
          <list-item>
            <p>Continuous variables for moderator analysis, including mean age of the sample and gender ratio</p>
          </list-item>
          <list-item>
            <p>Categorical variables for moderator analysis, including region the study where it was conducted, type of health care technology, and presence of technology demonstration</p>
          </list-item>
        </list>
        <p>The mean age was calculated using frequency counts in age-stratified data or directly extracted from the studies if provided. Geographic region was coded based on the location of the sample collection. The gender ratio was determined by dividing the number of male participants by the number of female participants. Technology domains were categorized into 4 distinct groups: mHealth (eg, mHealth apps and mHealth services), wearable (eg, smart clothing and smart watches), online and telemedicine (eg, online health platforms and remote consultations), and home and institutional health hardware (eg, fall monitoring systems and self-service health kiosks). The presence of technology demonstrations in the studies, whether through a video or live demonstration just before the survey or experiment, was recorded as a binary variable.</p>
      </sec>
      <sec>
        <title>Quality Assessment</title>
        <p>In total, 2 reviewers independently assessed the methodological quality of studies using the Newcastle-Ottawa Scale. The Newcastle-Ottawa Scale uses a star system to evaluate the methodological quality of studies. The adapted cross-sectional tool assigns up to 8 points across 3 domains: (1) selection of study groups (up to 4 points), (2) comparability of the groups based on age and sex (up to 2 points), and (3) assessment of outcomes (up to 2 points). For this study, it was adapted to properly evaluate TAM- and UTAUT-related studies. The ascertainment of exposure was evaluated based on the use of surveys, with a score of 1 if surveys were used and 0 if no information was given. The comparability domain assessed control for age and sex, with 2 points if both were controlled, 1 point if one was controlled, and 0 points if neither were controlled. The assessment of outcomes was based on the use of validated surveys and the reporting of Cronbach α, with 2 points if both were provided, 1 point if only the validated survey was used, and 0 points if neither were described.</p>
      </sec>
      <sec>
        <title>Data Synthesis and Analysis</title>
        <p>Data were synthesized according to the review objectives.</p>
        <sec>
          <title>Objective 1: Synthesize the Sample Size–Weighted Average of the PU-BI, PEOU-BI, and SI-BI Relationships for the Current Literature</title>
          <p>To pool the effect sizes, random-effects analysis was used to calculate the sample size–weighted correlation of the PU-BI, PEOU-BI, and SI-BI relationships. To pool the effect sizes, random-effects analysis was used instead of a fixed effects analysis because it accounts for variance that is not just from sampling error but differences in population, methodology, and setting [<xref ref-type="bibr" rid="ref29">29</xref>]. While the fixed effects model offers a more intuitive method of assigning weights that is solely based on sample size of the study [<xref ref-type="bibr" rid="ref30">30</xref>], the variations of TAM and UTAUT studies make the random-effects model more suitable. It was conducted using R (R Foundation for
Statistical Computing) with the <italic>meta</italic> package which contains functions that make it easy to run different types of meta-analyses [<xref ref-type="bibr" rid="ref31">31</xref>]. To address potential publication bias, funnel plots were generated through the <italic>meta</italic> package, providing a visual means to detect systematic bias in the meta-analysis. The trim-and-fill method was then applied to adjust for any detected bias, ensuring the pooled effect size was representative and robust. This method is able to account for missing effects that may arise from publication bias to correct for small-study effects for the pooled effect sizes [<xref ref-type="bibr" rid="ref32">32</xref>]. In summary, the study reported the sample size–weighted average of the 3 pairwise relationships, their 95% CIs, the adjusted weighted averages, and the adjusted 95% CIs.</p>
        </sec>
        <sec>
          <title>Objective 2: Identify Sources of Systematic Heterogeneity by Analyzing the Characteristics of the Primary Studies That Moderate the PU-BI, PEOU-BI, and SI-BI Relationships</title>
          <p>Meta-regression was used to explore the impact of the continuous moderators, such as age and gender, on the 3 pairwise relationships. The significance level for the beta coefficients was considered at <italic>P</italic>&#60;.05. Subgroup analysis was used for the categorical moderators region, technology domain, and presence of visual demonstration on the 3 pairwise relationships. A <italic>Q</italic> test was conducted to measure the heterogeneity between the subgroups and the difference was considered significant at <italic>P</italic>&#60;.05.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Selection</title>
        <p>The literature search process yielded 1167 studies (<xref rid="figure1" ref-type="fig">Figure 1</xref>). After the removal of duplicates, 928 studies remained for the full-text screening. After assessing the full-text articles for eligibility, the resulting number of studies included in the meta-analysis was 41. There were 2 studies that met the eligibility criteria after additional information was provided by the corresponding author.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA flow diagram of evidence search and selection.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e65269_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Study Characteristics</title>
        <p>The summary of the characteristics of the studies is included in <xref ref-type="table" rid="table1">Table 1</xref>. The total sample size of the primary studies was 11,574. Of the 41 studies, 33 (80%) explicitly included the mean age of participants, with an overall mean of 67.58 (SD 4.76) years and a range of 57.86 to 82.1 years. In total, 5 (12%) studies provided an exact age range: ≥60 years [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref33">33</xref>], 50 to 65 years [<xref ref-type="bibr" rid="ref34">34</xref>], and ≥50 years [<xref ref-type="bibr" rid="ref35">35</xref>]. The remaining 3 (7%) studies [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>], while not specifying a mean age, used consistent but indefinite terminology, such as <italic>elderly</italic> or <italic>older adults</italic> in their title, abstract, introduction, or methodology. Therefore, it was assumed that the sample of the 3 (7%) studies was consistent with the focus of this research and fell within the broader age range represented by the 33 (80%) studies that reported mean ages. In total, 36 (88%) studies reported the gender distribution of their samples, the total ratio being 2.00, with more female participants than male. For each technology type, there were 9 (22%) studies for wearable, 12 (29%) for mHealth, 12 (29%) for online or telemedicine, and 8 (19%) for home or institution hardware. In total, 23 (56%) studies were conducted in Asia (China, Taiwan, and Korea), 7 (17%) in Europe, 4 (10%) in the United States, and 7 (17%) in African-Islamic countries (Bangladesh, Saudi Arabia, and Pakistan). The description of the studies is included in <xref ref-type="table" rid="table2">Table 2</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Characteristics of 41 primary studies included in meta-analysis.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="270"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="180"/>
            <col width="150"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td>Author and year</td>
                <td>Sample size, n</td>
                <td>Age (y), mean</td>
                <td>Gender ratio</td>
                <td>Technology type</td>
                <td>Region</td>
                <td>Visual demonstration</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Akhter and Hossain [<xref ref-type="bibr" rid="ref39">39</xref>], 2022</td>
                <td>112</td>
                <td>57.86</td>
                <td>0.87</td>
                <td>mHealth<sup>a</sup></td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Alsswey and Al-Samarraie [<xref ref-type="bibr" rid="ref40">40</xref>], 2019</td>
                <td>81</td>
                <td>63.48</td>
                <td>0.35</td>
                <td>mHealth</td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Boontarig et al [<xref ref-type="bibr" rid="ref36">36</xref>], 2012</td>
                <td>31</td>
                <td>—<sup>b</sup></td>
                <td>—</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Cimperman et al [<xref ref-type="bibr" rid="ref41">41</xref>], 2016</td>
                <td>400</td>
                <td>61.13</td>
                <td>1.03</td>
                <td>Online or telemedicine</td>
                <td>Europe</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Cristescu et al [<xref ref-type="bibr" rid="ref37">37</xref>], 2022</td>
                <td>750</td>
                <td>—</td>
                <td>—</td>
                <td>Wearable</td>
                <td>Europe</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Diño and de Guzman [<xref ref-type="bibr" rid="ref38">38</xref>], 2014</td>
                <td>82</td>
                <td>—</td>
                <td>2.57</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Etemad-Sajadi and Gomes Dos Santos [<xref ref-type="bibr" rid="ref42">42</xref>], 2019</td>
                <td>213</td>
                <td>82.1</td>
                <td>2.60</td>
                <td>Home or institution hardware</td>
                <td>Europe</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Greer and Abel [<xref ref-type="bibr" rid="ref43">43</xref>], 2022</td>
                <td>30</td>
                <td>66.3</td>
                <td>—</td>
                <td>mHealth</td>
                <td>United States</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Hoque and Sorwar [<xref ref-type="bibr" rid="ref44">44</xref>], 2017</td>
                <td>274</td>
                <td>68.06</td>
                <td>0.51</td>
                <td>mHealth</td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Hsiao and Tang [<xref ref-type="bibr" rid="ref45">45</xref>], 2015</td>
                <td>338</td>
                <td>67.12</td>
                <td>1.08</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Jeng et al [<xref ref-type="bibr" rid="ref46">46</xref>], 2022</td>
                <td>166</td>
                <td>67.81</td>
                <td>1.24</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Khan et al [<xref ref-type="bibr" rid="ref24">24</xref>], 2022</td>
                <td>286</td>
                <td>—</td>
                <td>0.74</td>
                <td>mHealth</td>
                <td>African-Islamic</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2022</td>
                <td>269</td>
                <td>76.1</td>
                <td>1.10</td>
                <td>Home or institution hardware</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Koo et al [<xref ref-type="bibr" rid="ref26">26</xref>], 2023</td>
                <td>477</td>
                <td>64.31</td>
                <td>0.73</td>
                <td>mHealth</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Li et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2018</td>
                <td>146</td>
                <td>67.41</td>
                <td>0.78</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Li et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2021</td>
                <td>353</td>
                <td>70.38</td>
                <td>1.37</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Li et al [<xref ref-type="bibr" rid="ref19">19</xref>], 2023</td>
                <td>402</td>
                <td>—</td>
                <td>0.61</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Lu and Tsai-Lin [<xref ref-type="bibr" rid="ref13">13</xref>], 2024</td>
                <td>510</td>
                <td>75.13</td>
                <td>4.15</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Ma and Luo [<xref ref-type="bibr" rid="ref50">50</xref>], 2023</td>
                <td>1318</td>
                <td>63.98</td>
                <td>0.89</td>
                <td>mHealth</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Mahmood and Lee [<xref ref-type="bibr" rid="ref20">20</xref>], 2021</td>
                <td>376</td>
                <td>70</td>
                <td>1.56</td>
                <td>Wearable</td>
                <td>United States</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Mascret and Temprado [<xref ref-type="bibr" rid="ref51">51</xref>], 2023</td>
                <td>230</td>
                <td>66.61</td>
                <td>2.03</td>
                <td>Home or institution hardware</td>
                <td>Europe</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Mascret et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2020</td>
                <td>271</td>
                <td>73.69</td>
                <td>1.71</td>
                <td>Home or institution hardware</td>
                <td>Europe</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Maswadi et al [<xref ref-type="bibr" rid="ref15">15</xref>], 2022</td>
                <td>486</td>
                <td>70.80</td>
                <td>1.59</td>
                <td>Home or institution hardware</td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Mukherjee [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                <td>200</td>
                <td>70.75</td>
                <td>1.53</td>
                <td>Online or telemedicine</td>
                <td>United States</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Pal et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2018</td>
                <td>239</td>
                <td>67.14</td>
                <td>0.52</td>
                <td>Home or institution hardware</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Palas et al [<xref ref-type="bibr" rid="ref14">14</xref>], 2022</td>
                <td>493</td>
                <td>66.33</td>
                <td>0.18</td>
                <td>mHealth</td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Pate [<xref ref-type="bibr" rid="ref34">34</xref>], 2022</td>
                <td>128</td>
                <td>—</td>
                <td>—</td>
                <td>Wearable</td>
                <td>United States</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Pywell [<xref ref-type="bibr" rid="ref55">55</xref>], 2021</td>
                <td>313</td>
                <td>63.89</td>
                <td>1.52</td>
                <td>mHealth</td>
                <td>Europe</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Quaosar et al [<xref ref-type="bibr" rid="ref33">33</xref>], 2018</td>
                <td>245</td>
                <td>—</td>
                <td>—</td>
                <td>mHealth</td>
                <td>African-Islamic</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Ren and Zhou [<xref ref-type="bibr" rid="ref56">56</xref>], 2023</td>
                <td>200</td>
                <td>68.83</td>
                <td>1.33</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Rój [<xref ref-type="bibr" rid="ref57">57</xref>], 2022</td>
                <td>400</td>
                <td>64.5</td>
                <td>1.17</td>
                <td>Online or telemedicine</td>
                <td>Europe</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Talukder et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2020</td>
                <td>325</td>
                <td>67.89</td>
                <td>0.56</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Techatraiphum et al [<xref ref-type="bibr" rid="ref35">35</xref>], 2016</td>
                <td>45</td>
                <td>—</td>
                <td>—</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Tsai et al [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                <td>81</td>
                <td>69.7</td>
                <td>0.89</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Tu and Liu [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                <td>487</td>
                <td>67.11</td>
                <td>1.99</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Wang et al [<xref ref-type="bibr" rid="ref61">61</xref>], 2023</td>
                <td>365</td>
                <td>67.31</td>
                <td>1.28</td>
                <td>mHealth</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Wong et al [<xref ref-type="bibr" rid="ref27">27</xref>], 2014</td>
                <td>98</td>
                <td>64.93</td>
                <td>1</td>
                <td>Online or telemedicine</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Wu et al [<xref ref-type="bibr" rid="ref23">23</xref>], 2023</td>
                <td>78</td>
                <td>61.78</td>
                <td>1.69</td>
                <td>Home or institution hardware</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Xu et al [<xref ref-type="bibr" rid="ref62">62</xref>], 2022</td>
                <td>51</td>
                <td>68.96</td>
                <td>1.32</td>
                <td>Home or institution hardware</td>
                <td>Asia</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Zhang [<xref ref-type="bibr" rid="ref63">63</xref>], 2023</td>
                <td>55</td>
                <td>59.9</td>
                <td>0.67</td>
                <td>mHealth</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Zin et al [<xref ref-type="bibr" rid="ref64">64</xref>], 2023</td>
                <td>170</td>
                <td>68.85</td>
                <td>1.27</td>
                <td>Wearable</td>
                <td>Asia</td>
                <td>No</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>mHealth: mobile health.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>Not applicable.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Description of the characteristics of the included primary studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="470"/>
            <col width="0"/>
            <col width="500"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Characteristics</td>
                <td>Statistical results</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="3">Studies, n</td>
                <td>41</td>
              </tr>
              <tr valign="top">
                <td colspan="3">Total sample size</td>
                <td>11,574</td>
              </tr>
              <tr valign="top">
                <td colspan="3">Age (y), mean (SD)</td>
                <td>67.58 (4.76)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Gender ratio (female:male)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Mean (SD)</td>
                <td colspan="2">1.26 (4.52)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>&#62;1, n (%)</td>
                <td colspan="2">22 (61)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>≤1, n (%)</td>
                <td colspan="2">14 (39)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Technology type, n (%)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Wearable</td>
                <td colspan="2">9 (22)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Mobile health</td>
                <td colspan="2">12 (29)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Online or telemedicine</td>
                <td colspan="2">12 (29)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Home or institution hardware</td>
                <td colspan="2">8 (19)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Region, n (%)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Asia</td>
                <td colspan="2">23 (56)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Europe</td>
                <td colspan="2">7 (17)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>United States</td>
                <td colspan="2">4 (10)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>African-Islamic</td>
                <td colspan="2">7 (17)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Analysis Characteristics</title>
        <p>Of the 41 studies, most did not end with just a correlation analysis but conducted more in-depth statistical methods, such as structural equation modeling and multivariate regression. Although all the correlation coefficients were positive, certain studies reported path coefficients that were not statistically significant or did not have the exact pathway in their final model. The rate at which the correlation coefficient represents the final reporting of the studies is given in <xref ref-type="table" rid="table3">Table 3</xref>. For the PU-BI relationship, 41 correlation coefficients were extracted from a correlation matrix given in the study. Of the 41 correlation coefficients, 31 (76%) had PU-BI path analysis, 27 (66%) of which were significant and positive with a rate of 87% (27/31). For the PEOU-BI relationship, 41 correlation coefficients were extracted. Of the 41 studies, 28 (68%) included the PEOU-BI path analysis, 21 (51%) of which were positive and significant with a rate of 75% (21/28). For the SI-BI relationship, 28 correlation coefficients were extracted. Of the 28 studies, 21 (75%) included the SI-BI path analysis, 16 (57%) of which were positive and significant with a rate of 76% (16/21).</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Representativeness of final path analysis by correlation coefficient of pairwise relationships.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="200"/>
            <col width="200"/>
            <col width="200"/>
            <col width="200"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td>Pairwise relationship</td>
                <td>Frequency of correlation analysis, n</td>
                <td>Frequency of path analysis, n (%)</td>
                <td>Frequency of significant path analysis, n (%)</td>
                <td>Rate of significant path analysis (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Perceived usefulness–BI<sup>a</sup></td>
                <td>41</td>
                <td>31 (76)</td>
                <td>27 (66)</td>
                <td>87</td>
              </tr>
              <tr valign="top">
                <td>Perceived ease of use–BI</td>
                <td>41</td>
                <td>28 (68)</td>
                <td>21 (51)</td>
                <td>75</td>
              </tr>
              <tr valign="top">
                <td>Social influence–BI</td>
                <td>28</td>
                <td>21 (75)</td>
                <td>16 (57)</td>
                <td>76</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>BI: behavioral intention.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Quality Assessment</title>
        <sec>
          <title>Overview</title>
          <p>Of the 41 studies, the majority (n=27, 66%) were assessed to be of <italic>satisfactory</italic> quality. A few studies (14/41, 34%) were considered of <italic>good</italic> quality. No studies were assessed as <italic>very good</italic> quality or <italic>unsatisfactory</italic> quality. Quality assessment results (<xref ref-type="table" rid="table4">Table 4</xref>) for these studies are summarized in the following sections.</p>
          <table-wrap position="float" id="table4">
            <label>Table 4</label>
            <caption>
              <p>Newcastle-Ottawa Scale for quality assessment of the included studies.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="180"/>
              <col width="100"/>
              <col width="90"/>
              <col width="100"/>
              <col width="110"/>
              <col width="0"/>
              <col width="120"/>
              <col width="0"/>
              <col width="100"/>
              <col width="100"/>
              <col width="0"/>
              <col width="100"/>
              <thead>
                <tr valign="top">
                  <td>Study</td>
                  <td colspan="5">Selection</td>
                  <td colspan="2">Comparability</td>
                  <td colspan="3">Outcome</td>
                  <td>Quality score<sup>a</sup></td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Representativeness</td>
                  <td>Sample size</td>
                  <td>Nonrespondents</td>
                  <td>Ascertainment of the exposure</td>
                  <td colspan="2">Confounding factors controlled</td>
                  <td colspan="2">Assessment of outcome</td>
                  <td>Statistical test</td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>Akhter and Hossain [<xref ref-type="bibr" rid="ref39">39</xref>], 2022</td>
                  <td>0</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Alsswey and Al-Samarraie [<xref ref-type="bibr" rid="ref40">40</xref>], 2020</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Boontarig et al [<xref ref-type="bibr" rid="ref36">36</xref>], 2012</td>
                  <td>Unsure</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Cimperman et al [<xref ref-type="bibr" rid="ref41">41</xref>], 2016</td>
                  <td>1</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Cristescu et al [<xref ref-type="bibr" rid="ref37">37</xref>], 2022</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Diño and de Guzman [<xref ref-type="bibr" rid="ref38">38</xref>], 2014</td>
                  <td>0</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Etemad-Sajadi and Gomes Dos Santos [<xref ref-type="bibr" rid="ref42">42</xref>], 2019</td>
                  <td>0</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Greer and Abel [<xref ref-type="bibr" rid="ref43">43</xref>], 2022</td>
                  <td>0</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Hoque and Sorwar [<xref ref-type="bibr" rid="ref44">44</xref>], 2017</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Hsiao and Tang [<xref ref-type="bibr" rid="ref45">45</xref>], 2015</td>
                  <td>1</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Jeng et al [<xref ref-type="bibr" rid="ref46">46</xref>], 2022</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Khan et al [<xref ref-type="bibr" rid="ref24">24</xref>], 2022</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Kim et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2022</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Koo et al [<xref ref-type="bibr" rid="ref26">26</xref>], 2023</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Li et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2019</td>
                  <td>0</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Li et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2021</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Li et al [<xref ref-type="bibr" rid="ref19">19</xref>], 2023</td>
                  <td>0</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Lu and Tsai-Lin [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Ma and Luo [<xref ref-type="bibr" rid="ref50">50</xref>], 2023</td>
                  <td>0</td>
                  <td>1</td>
                  <td>0</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Mahmood &#38; Lee [<xref ref-type="bibr" rid="ref20">20</xref>], 2021</td>
                  <td>1</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Mascret and Temprado [<xref ref-type="bibr" rid="ref51">51</xref>], 2023</td>
                  <td>0</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Mascret et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2020</td>
                  <td>1</td>
                  <td>1</td>
                  <td>0</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Maswadi et al [<xref ref-type="bibr" rid="ref15">15</xref>], 2022</td>
                  <td>1</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Mukherjee [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                  <td>0</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Pal et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2018</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Palas et al [<xref ref-type="bibr" rid="ref14">14</xref>], 2022</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Pate [<xref ref-type="bibr" rid="ref34">34</xref>], 2022</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Pywell [<xref ref-type="bibr" rid="ref55">55</xref>], 2021</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Quaosar et al [<xref ref-type="bibr" rid="ref33">33</xref>], 2018</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Ren and Zhou [<xref ref-type="bibr" rid="ref56">56</xref>], 2023</td>
                  <td>1</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Rój [<xref ref-type="bibr" rid="ref57">57</xref>], 2022</td>
                  <td>1</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Talukder et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2020</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Techatraiphum et al [<xref ref-type="bibr" rid="ref35">35</xref>], 2016</td>
                  <td>0</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Tsai et al [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                  <td>0</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Tu and Liu [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                  <td>0</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Wang et al [<xref ref-type="bibr" rid="ref61">61</xref>], 2023</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td>1</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Good</td>
                </tr>
                <tr valign="top">
                  <td>Wong et al [<xref ref-type="bibr" rid="ref27">27</xref>], 2014</td>
                  <td>Unsure</td>
                  <td>Unsure</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Wu et al [<xref ref-type="bibr" rid="ref23">23</xref>], 2023</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Xu et al [<xref ref-type="bibr" rid="ref62">62</xref>], 2022</td>
                  <td>0</td>
                  <td>Unsure</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Zhang [<xref ref-type="bibr" rid="ref63">63</xref>], 2023</td>
                  <td>0</td>
                  <td>1</td>
                  <td>0</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
                <tr valign="top">
                  <td>Zin et al [<xref ref-type="bibr" rid="ref64">64</xref>], 2023</td>
                  <td>0</td>
                  <td>1</td>
                  <td>Unsure</td>
                  <td>1</td>
                  <td colspan="2">0</td>
                  <td colspan="2">1</td>
                  <td>1</td>
                  <td colspan="2">Satisfactory</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table4fn1">
                <p><sup>a</sup>Very good studies: 7 to 8 points, good studies: 5 to 6 points, satisfactory studies: 3 to 4 points, and unsatisfactory studies: 0 to 2 points.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
        <sec>
          <title>Selection</title>
          <p>In the selection domain, the studies demonstrated varied results. A small number of studies (10/41, 24%) had representative samples, with most studies (37/41, 90%) applying convenience or purposive sampling to gain an unrepresentative sample. Around half of the studies (20/41, 49%) provided adequate sample size, either with a sample size over 400 or by providing justification for their size. Less than half (19/41, 46%) studies had a response rate &#62;80%, while 18 (44%) studies did not provide sufficient details, and 4 (10%) studies had a response rate &#60;80%. All studies were given 1 star for the ascertainment of exposure as the information was obtained through surveys.</p>
        </sec>
        <sec>
          <title>Comparability</title>
          <p>Regarding comparability, all studies received 0 stars in this domain. This is because, while some studies did control for age or gender through structural equation modeling or multivariate regression, the information used in this analysis was based on correlation coefficients before these controls were applied.</p>
        </sec>
        <sec>
          <title>Outcome</title>
          <p>In the outcome domain, all studies were given the maximum score of 2 stars for the assessment of the outcome. Specifically, all 41 studies used validated questionnaires from previous TAM and UTAUT studies and reported Cronbach α values, which demonstrated the reliability of the measures. This consistent use of validated measures and reliability reporting supports the overall credibility of the outcome data.</p>
        </sec>
      </sec>
      <sec>
        <title>Effect Sizes and Publication Bias Adjustment</title>
        <p>The weighted average of the correlations of the 3 pairwise relationships, PU-BI (<italic>r</italic>=0.607, 95% CI 0.543-0.665; <italic>P</italic>&#60;.001), PEOU-BI (<italic>r</italic>=0.525, 95% CI 0.462-0.583; <italic>P</italic>&#60;.001), and SI-BI (<italic>r</italic>=0.551, 95% CI 0.468-0.624; <italic>P</italic>&#60;.001), was calculated using the random-effects model. The CI of each effect indicated a positive relationship for the intention to accept technology. The heterogeneity was calculated through a <italic>Q</italic> test and an <italic>I</italic><sup>2</sup> test for PU-BI (<italic>Q</italic><sub>40</sub>=973.77; <italic>P</italic>&#60;.001; I<sup>2</sup>=95.9%), PEOU-BI (<italic>Q</italic><sub>40</sub>=626.95; <italic>P</italic>&#60;.001; I<sup>2</sup>=93.6%), and SI-BI (<italic>Q</italic><sub>27</sub>=580.59; <italic>P</italic>&#60;.001; I<sup>2</sup>=95.3%), all of which showed a high degree of heterogeneity. To test the possibility of publication bias, the funnel plot method was used to detect any asymmetry. If detected, the trim-and-fill method was used to adjust the weighted average of the effect by filling in additional points to maintain symmetry. Among the 3 relationships, SI-BI required 6 additional points as shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>, while the PU-BI and SI-BI required none. The weighted average of the effect sizes and the adjustments after the trim-and-fill are reported in <xref ref-type="table" rid="table5">Table 5</xref>. The table summarizes the results of the 3 pairwise relationships through quantitative synthesis by confirming that each pair has a positive association, indicating that the intention to accept health care technology is dependent on the usefulness, ease of use, and SI.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Funnel plot of social influence–behavioral intention relationship after trim and fill.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e65269_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Weighted correlation of pairwise relationships of studies included.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="250"/>
            <col width="250"/>
            <col width="250"/>
            <col width="250"/>
            <thead>
              <tr valign="top">
                <td>Pairwise relationship</td>
                <td>Total sample size, n</td>
                <td>Weighted correlation, <italic>r</italic> (95% CI)</td>
                <td>Adjusted weighted correlation, <italic>r</italic> (adjusted 95% CI)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Perceived usefulness–BI<sup>a</sup></td>
                <td>11,574</td>
                <td>0.607 (0.542-0.665)</td>
                <td>0.607 (0.542-0.665)</td>
              </tr>
              <tr valign="top">
                <td>Perceived ease of use–BI</td>
                <td>11,574</td>
                <td>0.525 (0.462-0.583)</td>
                <td>0.525 (0.462-0.583)</td>
              </tr>
              <tr valign="top">
                <td>Social influence–BI</td>
                <td>8264</td>
                <td>0.559 (0.476-0.632)</td>
                <td>0.471 (0.363-0.566)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table5fn1">
              <p><sup>a</sup>BI: behavioral intention.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Moderator Analysis</title>
        <sec>
          <title>Age</title>
          <p>Of the 41 studies, 33 (80%) were included in the meta-regression with the sample age as its coefficient. One relationship, PU-BI (β=0.000; <italic>P</italic>=.99), was positively associated with the mean age of the sample while PEOU-BI (β=−0.126; <italic>P</italic>=.19) and SI-BI (β=−0.017; <italic>P</italic>=.35) were negatively associated with age. However, the significance test showed that the results for the 3 relationships were not significant.</p>
        </sec>
        <sec>
          <title>Gender</title>
          <p>While 35 primary studies reported the number of female and male participants, 1 study [<xref ref-type="bibr" rid="ref43">43</xref>] that involved 29 females and 1 male was removed as it was deemed an outlier. Therefore, the remaining 34 studies were included in the meta-regression with the female-to-male ratio as its coefficient. PU-BI (β=0.126, <italic>P</italic>=.07), PEOU-BI (β=0.037, <italic>P</italic>=.56), and SI-BI (β=0.105, <italic>P</italic>=.34), were positively associated with the proportions of female participants over the male participants. However, the significance test proved none of the relationships to be significant.</p>
        </sec>
        <sec>
          <title>Geographic Region</title>
          <p>A subgroup analysis of the geographic regions was conducted to report the effect size of each relationship for each region, the United States, Europe, Asia, and African- Islamic. From highest to lowest in correlation for PU-BI (<italic>Q</italic><sub>3</sub>=6.3; <italic>P</italic>=.10), the order was the United States (<italic>r</italic>=0.713), Europe (<italic>r</italic>=0.712), Asia (<italic>r</italic>=0.572), and African-Islamic (<italic>r</italic>=0.529). For PEOU-BI (<italic>Q</italic><sub>3</sub>=8.27; <italic>P</italic>=.04), the order was Europe (<italic>r</italic>=0.628), the United States (<italic>r</italic>=0.587), Asia (<italic>r</italic>=0.492), and African-Islamic (<italic>r</italic>=0.480). For SI-BI (<italic>Q</italic><sub>3</sub>=2.63; <italic>P</italic>=.45), the order was the United States (<italic>r</italic>=0.700), Europe (<italic>r</italic>=0.602), Asia (<italic>r</italic>=0.548), and African-Islamic (<italic>r</italic>=0.495). After conducting a <italic>Q</italic> test, it was observed that only the PEOU-BI relationship (<xref rid="figure3" ref-type="fig">Figure 3</xref>) had a difference in the subgroups large enough to be considered significant.</p>
          <fig id="figure3" position="float">
            <label>Figure 3</label>
            <caption>
              <p>Subgroup analysis of region for perceived ease of use–behavioral intention relationship.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e65269_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Technology Type</title>
          <p>All studies were involved in a subgroup analysis of the technology type, which were divided into wearable, mHealth, online or telehealth, and home or institutional. For PU-BI (<italic>Q</italic><sub>3</sub>=8.08; <italic>P</italic>=.04), the order from highest to lowest in correlation was home or institutional (<italic>r</italic>=0.736), wearable (<italic>r</italic>=0.642), mHealth (<italic>r</italic>=0.578), and online or telehealth (<italic>r</italic>=0.501). For PEOU-BI (<italic>Q</italic><sub>3</sub>=4.15; <italic>P</italic>=.25), it was home or institutional (<italic>r</italic>=0.641), mHealth (<italic>r</italic>=0.510), online or telehealth (<italic>r</italic>=0.489), and wearable (<italic>r</italic>=0.467). For SI-BI (<italic>Q</italic><sub>3</sub>=14.75; <italic>P</italic>=.002), the order was home or institutional (<italic>r</italic>=0.690), wearable (<italic>r</italic>=0.664), mHealth (<italic>r</italic>=0.550), and online or telehealth (<italic>r</italic>=0.415). The <italic>Q</italic> test for the PU-BI (<xref rid="figure4" ref-type="fig">Figure 4</xref>) and SI-BI (<xref rid="figure5" ref-type="fig">Figure 5</xref>) proved the differences in the subgroups to be significant but not for PEOU-BI.</p>
          <fig id="figure4" position="float">
            <label>Figure 4</label>
            <caption>
              <p>Subgroup analysis of health care technology type for perceived usefulness–behavioral intention relationship. mHealth: mobile health.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e65269_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <fig id="figure5" position="float">
            <label>Figure 5</label>
            <caption>
              <p>Subgroup analysis of health care technology type for social influence–behavioral intention relationship. mHealth: mobile health.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e65269_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Visual Demonstration</title>
          <p>A subgroup analysis was conducted by dividing the studies into 2 groups, one that involved a visual demonstration of the technology before the survey, and one without. For the relationship PU-BI (<italic>Q</italic><sub>1</sub>=4.24; <italic>P</italic>=.04), studies that provided a visual demonstration (<italic>r</italic>=0.706) had a higher effect size compared to studies that did not (<italic>r</italic>=0.554). For PEOU-BI (<italic>Q</italic><sub>1</sub>=0.16; <italic>P</italic>=.69), studies that provided a visual demonstration (<italic>r</italic>=0.535) displayed a lower effect compared to studies that did not (<italic>r</italic>=0.501). Finally, for SI-BI (<italic>Q</italic><sub>1</sub>=4.38; <italic>P</italic>=.04), studies that provided a visual demonstration (<italic>r</italic>=0.670) displayed a higher effect than studies without (<italic>r</italic>=0.492). For PU-BI (<xref rid="figure6" ref-type="fig">Figure 6</xref>) and SI-BI (<xref rid="figure7" ref-type="fig">Figure 7</xref>), the <italic>Q</italic> test proved the significance of their difference but not for PEOU-BI.</p>
          <fig id="figure6" position="float">
            <label>Figure 6</label>
            <caption>
              <p>Subgroup analysis of presence of visual demonstration for perceived usefulness–behavioral intention relationship.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e65269_fig6.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <fig id="figure7" position="float">
            <label>Figure 7</label>
            <caption>
              <p>Subgroup analysis of presence of visual demonstration for social influence–behavioral intention relationship.</p>
            </caption>
            <graphic xlink:href="jmir_v27i1e65269_fig7.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This meta-analysis aimed to address 2 primary objectives: synthesizing the current evidence on health care technology acceptance among older adults and identifying potential sources of heterogeneity. The findings revealed significant positive correlations for all 3 key relationships: PU-BI (<italic>r</italic>=0.607), PEOU-BI (<italic>r</italic>=0.525), and SI-BI (<italic>r</italic>=0.551). Further analysis identified significant moderating effects of geographic region on PEOU-BI, technology type on both PU-BI and SI-BI, and visual demonstrations on PU-BI and SI-BI relationships, while age and gender showed no significant moderating effects.</p>
      </sec>
      <sec>
        <title>Overall Effect Sizes</title>
        <p>The pooled results extend our understanding of how older adults accept health care technology. While a separate study noted a lower correlation between PU and BI for health care technology compared to other types of technology [<xref ref-type="bibr" rid="ref65">65</xref>], our meta-analysis revealed that PU maintains a strong influence on older adults’ intention to use health care technology. The significant PEOU-BI relationship aligns with the understanding that older adults may face cognitive and physical challenges [<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], making ease of use particularly crucial for technology adoption and accessibility [<xref ref-type="bibr" rid="ref68">68</xref>]. The strong SI-BI relationship confirms the substantial influence of family members, friends, and caregivers on health care technology adoption decisions [<xref ref-type="bibr" rid="ref65">65</xref>], providing empirical support for the importance of social networks in technology acceptance among older adults.</p>
      </sec>
      <sec>
        <title>Moderator Analysis</title>
        <sec>
          <title>Age</title>
          <p>The analysis revealed that the relationships between the constructs and BI did not vary with age. This is in line with the results from the study by Ma et al [<xref ref-type="bibr" rid="ref28">28</xref>] that found a lack of moderating effect of age for acceptance of various types of technology, suggesting that a deeper look into health care technology reports the same results [<xref ref-type="bibr" rid="ref28">28</xref>]. In addition, meta-analysis by Hauk et al [<xref ref-type="bibr" rid="ref69">69</xref>] reported that age has a negative effect on TAM constructs unless the technology in question addresses the needs of older individuals, explaining the absence of a moderating effect on health care technology. Such results provide a new way of understanding the effect of age for technology acceptance that differs from the age stereotypes that assume a negative effect of age.</p>
        </sec>
        <sec>
          <title>Gender</title>
          <p>The gender analysis did not show any significant effect on the relationships studied, suggesting that gender does not significantly impact the acceptance decisions related to health care technology. A review paper [<xref ref-type="bibr" rid="ref70">70</xref>] concluded that the influence of gender on technology adoption depends on the context and type of technology, implying that gender effects may not be relevant in the context of health care technology. It is important to note that the primary studies included in this meta-analysis had more female participants than male, which could introduce potential bias. Consequently, the results related to gender should be interpreted with caution, and future research should aim for a more balanced sample to ensure comprehensive understanding of health care technology acceptance among older adults.</p>
        </sec>
        <sec>
          <title>Geographic Region</title>
          <p>Subgroup analysis by geographic region revealed that for PU-BI, the United States and Europe displayed the highest correlations, followed by Asia and African-Islamic regions, indicating that PU is more strongly related to BI in Western cultures. For PEOU-BI, Europe showed the highest correlation, followed by the United States, Asia, and African-Islamic regions. This is in line with the findings of McCoy et al [<xref ref-type="bibr" rid="ref71">71</xref>] that reported that the PU-BI and PEOU-BI relationship tends to be weaker for countries that have a higher power distance. The countries in the Asia category (China, Taiwan, and Korea) and African-Islamic category (Bangladesh, Saudi Arabia, and Pakistan) report much higher power distance.</p>
        </sec>
        <sec>
          <title>Technology Type</title>
          <p>Home or institutional hardware exhibited the highest correlations for both PU and PEOU. These technologies, which include devices such as smart home systems and health kiosks, are inherently designed to improve quality of life, making their usefulness and user-friendliness paramount to their adoption [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref72">72</xref>]. In contrast, online or telehealth technologies showed the lowest correlations across PU and SI. This suggests factors such as privacy or trust as identified in other studies [<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>] may be more critical determinants of acceptance. Another important finding is the high correlation of SI-BI and low correlation of PEOU-BI for wearable technology. This suggests that social proof and endorsements could be powerful tools in promoting wearable technology within this demographic. A possible reason for this is because wearable technology is not perceived as just a health care technology but as a fashion accessory [<xref ref-type="bibr" rid="ref75">75</xref>], which is why production quality and social value are important factors [<xref ref-type="bibr" rid="ref58">58</xref>].</p>
        </sec>
        <sec>
          <title>Visual Demonstration</title>
          <p>The significant differences observed in the studies that included visual demonstrations emphasize the crucial role of reducing perceived risk in consumer theory for the acceptance of health care technology by older adults. Perceived social risk and physical risk play an important role when acquiring information about new technology [<xref ref-type="bibr" rid="ref76">76</xref>] but visual demonstrations can reduce the abstractness and uncertainty surrounding new health care technology by providing clear, tangible evidence of its functionality. Specifically for older adults, perception of automated vehicles, such as its PU, for older adults improved after exposure to a simulator and a demonstration in an automated shuttle [<xref ref-type="bibr" rid="ref77">77</xref>]. Similarly, a practical engagement may solidify the constructs of PU, PEOU, and SI by directly showcasing exactly how the technology works and its practical benefits, thus making other unidentified variables influencing BI less significant.</p>
        </sec>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This meta-analysis has several important limitations that should be considered when interpreting the findings. First, the main source of analysis, which is the correlation coefficient of the TAM constructs, were used instead of the finalized path coefficient of the primary studies. While this ensures the comparability and synthesis of the weighted averages of the effect sizes, it may not fully represent the results of the primary studies as the control variables are removed in the correlation analysis. Second, the substantial heterogeneity observed across the included studies, as reflected in the high <italic>I</italic>² values (PU-BI: 95.9%, PEOU-BI: 93.6%, and SI-BI: 95.3%), represents a significant limitation. This heterogeneity likely stems from differences in study populations, geographic regions, types of health care technology, and methodologies. Although the use of a random-effects model mitigated the impact of this variability by accounting for between-study differences, it remains challenging to generalize the findings to all older adult populations or health care technologies. Researchers should interpret the pooled effect sizes cautiously, as they represent averages across diverse study contexts rather than universally consistent effects. Third, the definition of <italic>older adults</italic> varied across the included studies, with most defining participants as &#62;60 years of age [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>], while others set the range at 55 years [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], 50 years [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>], or ≥65 years [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. Some studies did not clearly specify participant ages, relying instead on general descriptors such as <italic>older adults</italic> or <italic>elderly</italic>. Although the meta-regression suggested that mean age did not significantly influence the results, this variation reflects a potential limitation in how age was operationalized. This lack of consistency should be considered when interpreting the findings, and future research should aim for more standardized age definitions. Finally, the use of different methods across studies to collect information has noteworthy limitations. Although most studies obtained their data through web-based surveys, other methods such as face-to-face distribution, telephone, and mobile surveys were used, creating the possibility of the mode effect.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This meta-analysis provides a framework to understand and interpret the heterogeneous nature of health care technology acceptance among older adults. Rather than viewing inconsistent findings in previous literature as methodological weaknesses, our results suggest they may reflect genuine variations in acceptance patterns across different contexts and technologies. These insights have important implications for both research and practice. Future studies should carefully consider and report contextual factors that our analysis has identified as significant moderators, while also addressing current methodological limitations through standardized age definitions and balanced sampling approaches. This could lead to a more comprehensive understanding of technology acceptance among older adults and support the development of more effective implementation strategies for health care technology—an increasingly important consideration as health care systems worldwide adapt to serve older adult populations.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Complete search term and additional figures.</p>
        <media xlink:href="jmir_v27i1e65269_app1.docx" xlink:title="DOCX File , 1198 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>PRISMA checklist.</p>
        <media xlink:href="jmir_v27i1e65269_app2.docx" xlink:title="DOCX File , 23 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BI</term>
          <def>
            <p>behavioral intention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PEOU</term>
          <def>
            <p>perceived ease of use</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PU</term>
          <def>
            <p>perceived usefulness</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">SI</term>
          <def>
            <p>social influence</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">TAM</term>
          <def>
            <p>technology acceptance model</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">UTAUT</term>
          <def>
            <p>unified theory of acceptance and use of technology</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This study received support from the BK21 Plus Postgraduate Organization for Content Science, awarded to the authors. It was also supported by National Research Foundation of Korea funded by the ministry of Science and International Cooperative Development grant NRF-2022M3J6A1063021. The funder was not involved in the study’s design, data collection, and analysis; the decision to publish; or the preparation of the manuscript. No generative artificial intelligence tools were used to create the original content for publication.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The datasets generated or analyzed during this study are available in the Figshare repository [<xref ref-type="bibr" rid="ref78">78</xref>].</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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