<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v27i1e60410</article-id><article-id pub-id-type="doi">10.2196/60410</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Loneliness and Problematic Media Use: Meta-Analysis of Longitudinal Studies</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name name-style="western"><surname>Fam</surname><given-names>Jia Yuin</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>M&#x00E4;nnikk&#x00F6;</surname><given-names>Niko</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib></contrib-group><aff id="aff1"><institution>School of Psychology, Faculty of Medical and Life Sciences, Sunway University</institution><addr-line>5 Jalan Universiti</addr-line><addr-line>Bandar Sunway</addr-line><country>Malaysia</country></aff><aff id="aff2"><institution>Centre for Research and Innovation, Oulu University of Applied Sciences</institution><addr-line>Oulu</addr-line><country>Finland</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Cardoso</surname><given-names>Taiane de Azevedo</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Hess</surname><given-names>Lisa</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Seydavi</surname><given-names>Mohammad</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to  Jia Yuin Fam, PhD, School of Psychology, Faculty of Medical and Life Sciences, Sunway University, 5 Jalan Universiti, Bandar Sunway, 47500, Malaysia, 60 374918622 ext 7183; <email>jiayuinf@sunway.edu.my</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>all authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>14</day><month>8</month><year>2025</year></pub-date><volume>27</volume><elocation-id>e60410</elocation-id><history><date date-type="received"><day>10</day><month>05</month><year>2024</year></date><date date-type="rev-recd"><day>02</day><month>02</month><year>2025</year></date><date date-type="accepted"><day>05</day><month>03</month><year>2025</year></date></history><copyright-statement>&#x00A9; Jia Yuin Fam, Niko M&#x00E4;nnikk&#x00F6;. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 14.8.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2025/1/e60410"/><abstract><sec><title>Background</title><p>The association between loneliness and problematic media use has been evaluated in longitudinal studies and meta-analyses. However, previous meta-analyses have relied heavily on Pearson correlation coefficients, which may not fully account for the complexities of this association. Therefore, an updated meta-analysis incorporating more robust statistical models is needed.</p></sec><sec><title>Objective</title><p>This study aimed to examine the longitudinal relationship between loneliness and problematic media use using various statistical models and to explore potential moderators that might influence the strength of this relationship.</p></sec><sec sec-type="methods"><title>Methods</title><p>A systematic search was conducted using Scopus, APA PsycArticles, and PubMed  to identify eligible studies up to January 24, 2024. Inclusion criteria included studies written in English, published in a peer-reviewed journal, reporting estimates of the longitudinal relationship between loneliness and problematic media use, and a longitudinal study design. Estimates of the longitudinal relationship were synthesized using a random-effects model. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess the risk of bias.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 26 studies involving 24,798 individuals were included in the meta-analysis. Random-effects models revealed bidirectional relationships between loneliness and problematic media use. The longitudinal relationships were weaker when examined using estimated beta coefficients (<inline-formula><mml:math id="ieqn1"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>L</mml:mi><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.10; <inline-formula><mml:math id="ieqn2"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi><mml:mi>L</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.09), followed by other statistical models (<inline-formula><mml:math id="ieqn3"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>L</mml:mi><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.10; <inline-formula><mml:math id="ieqn4"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi><mml:mi>L</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.10) and the Pearson correlation coefficient (<inline-formula><mml:math id="ieqn5"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>L</mml:mi><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.28; <inline-formula><mml:math id="ieqn6"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mi>M</mml:mi><mml:mi>U</mml:mi><mml:mi>L</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>= 0.29). Subgroup analyses demonstrated stable results for beta coefficients across various study-level characteristics (including country, lag length, measure of problematic media use, and measure of loneliness), except for type of problematic media use (<italic>Q</italic>=16.58; <italic>P</italic>&#x003C;.001).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>This meta-analysis identified smaller effect sizes for the longitudinal relationships between loneliness and problematic media use compared with the previous meta-analysis. The weaker longitudinal relationship observed when using estimated beta coefficients highlights important methodological considerations for future meta-analyses. However, the contour-enhanced funnel plot and Egger regression test revealed an asymmetrical pattern, emphasizing the need for more longitudinal studies in this area.</p></sec><sec><title>Trial Registration</title><p>OSF Registry 3P6JR; https://doi.org/10.17605/OSF.IO/3P6JR</p></sec></abstract><kwd-group><kwd>bidirectional relationship</kwd><kwd>loneliness</kwd><kwd>longitudinal studies</kwd><kwd>meta-analysis</kwd><kwd>problematic media use</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><sec id="s1-1"><title>Background</title><p>The internet has become an integral part of daily life, fundamentally transforming social interaction compared with its predecessors, such as the telegraph, telephone, and television [<xref ref-type="bibr" rid="ref1">1</xref>]. The internet offers a vast array of opportunities for communication, entertainment, and social connection. However, this ease of access has also brought about concerns regarding problematic media use. Problematic media use involves behaviors that go beyond typical or normative media consumption and may include internet-related activities such as excessive gaming, online shopping, and social network use [<xref ref-type="bibr" rid="ref2">2</xref>]. Consequently, problematic media use is characterized by an individual&#x2019;s continued or escalated media or internet over-engagement despite significant impairment to daily functioning across different areas of life [<xref ref-type="bibr" rid="ref3">3</xref>]. According to Pan et al [<xref ref-type="bibr" rid="ref4">4</xref>], the pooled average prevalence rate of problematic media use among the general population is around 7%, but it can be significantly higher among youth. In this study, problematic media use includes popular media platforms frequently used by youth, including social media, smartphones, the internet, and gaming. These media platforms have gained considerable attention in research.</p></sec><sec id="s1-2"><title>Internet Paradox</title><p>The internet paradox [<xref ref-type="bibr" rid="ref5">5</xref>] suggests that despite the internet&#x2019;s potential to enhance social connection, it may paradoxically lead to decreased social engagement. While it offers a wider range of social functionalities compared with traditional media, its use for asocial purposes (eg, private entertainment) may hinder face-to-face social interaction [<xref ref-type="bibr" rid="ref5">5</xref>]. As a result, problematic media use (eg, excessive social media scrolling and compulsive gaming) may lead to unintentional social isolation despite the presence of numerous online connections.</p><p>Expanding on this internet paradox, numerous cross-sectional studies have yielded empirical evidence of a link between feelings of loneliness and problematic use of various modern media platforms, including gaming [<xref ref-type="bibr" rid="ref6">6</xref>], social media [<xref ref-type="bibr" rid="ref7">7</xref>], smartphones [<xref ref-type="bibr" rid="ref8">8</xref>], and internet use in general [<xref ref-type="bibr" rid="ref9">9</xref>]. Collectively, these studies consistently report a significant positive correlation, suggesting that individuals experiencing loneliness tend to engage in higher levels of problematic media use. Further supporting this link, a meta-analysis [<xref ref-type="bibr" rid="ref10">10</xref>] of 26 studies (mostly cross-sectional) found a positive association between loneliness and problematic media use (pooled <italic>r</italic> range between 0.20 and 0.26). Several reviews have reached similar conclusions about this significant relationship [<xref ref-type="bibr" rid="ref11">11</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. However, a critical limitation identified in these reviews is the predominant use of cross-sectional designs, making it difficult to establish the causal direction in the relationship between loneliness and problematic media use.</p></sec><sec id="s1-3"><title>Direction of Causality Between Loneliness and Problematic Media Use</title><p>This prompts an inquiry into the directionality of this relationship. Some studies suggest that loneliness may precede problematic media use [<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref16">16</xref>], as individuals experiencing loneliness may seek social connection through online platforms. According to the compensatory internet use theory [<xref ref-type="bibr" rid="ref17">17</xref>], individuals may engage in internet activities to fulfill unmet social needs. The internet offers various avenues for social interaction, ranging from active participation (eg, joining online gaming communities) to passive consumption (eg, browsing stories in social media). Lonely individuals may initially use the internet to satisfy their social needs. However, while this strategy may provide short-term fulfillment, it can lead to a cycle of dependence on the internet to meet these social needs. This dependence can make it difficult for individuals to disengage from the virtual world, potentially resulting in problematic media use.</p><p>Conversely, evidence suggests that problematic media use can also contribute to loneliness [<xref ref-type="bibr" rid="ref18">18</xref>]. Individuals who become excessively reliant on online interactions may neglect face-to-face social connections, potentially leading to feelings of isolation [<xref ref-type="bibr" rid="ref5">5</xref>]. This aligns with media displacement theory [<xref ref-type="bibr" rid="ref19">19</xref>], which posits that excessive media consumption can displace real-world social activities. The perceived convenience of the internet, particularly its ability to remove geographical and temporal constraints, might incentivize individuals to substitute face-to-face interactions with online social activities. While successful online relationships exist, research suggests that the quality of online relationships might be poorer than those in physical settings [<xref ref-type="bibr" rid="ref20">20</xref>]. Online communication is argued to be better suited for maintaining weak ties (superficial connections) rather than strong ties (close relationships).</p><p>The contrasting perspectives on the direction of causality between loneliness and problematic media use create a bidirectional relationship, suggesting that the 2 variables may influence each other. However, the strength of the longitudinal relationships appears to vary considerably across studies. While some longitudinal studies support the relationship in both directions, with effect sizes ranging from weak [<xref ref-type="bibr" rid="ref21">21</xref>] to strong [<xref ref-type="bibr" rid="ref22">22</xref>], other studies report a nonsignificant longitudinal relationship [<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>In light of this consideration, a meta-analysis that synthesizes past longitudinal findings might provide the best estimate for the longitudinal relationships. Previous meta-analysis examining the longitudinal relationship between loneliness and problematic internet use revealed significant positive correlations in both directions [<xref ref-type="bibr" rid="ref24">24</xref>]. While their work is valuable, it is noteworthy that they extracted and synthesized Pearson correlation coefficients from past studies (eg, the correlation between loneliness at Time 1 and problematic internet use at Time 2). However, pooling the Pearson coefficients might not be entirely accurate because they do not account for the effect of the outcome variable at Time 1 (ie, problematic internet use at Time 1). For instance, 1 study [<xref ref-type="bibr" rid="ref25">25</xref>] included in a meta-analysis by Zhang et al [<xref ref-type="bibr" rid="ref24">24</xref>] reported a Pearson correlation of 0.22 between loneliness at Time 1 and problematic internet use at Time 2. However, their cross-lagged model revealed a nonsignificant standardized beta coefficient of only 0.05 for the same causal relationship. This suggests that the pooled correlations reported by the meta-analysis [<xref ref-type="bibr" rid="ref24">24</xref>] might be overestimated.</p></sec><sec id="s1-4"><title>Objective</title><p>The limitations of cross-sectional studies (eg, inability to establish causality), varying past findings from longitudinal studies, and reliance on Pearson correlation coefficients in previous meta-analyses underscore the need for a more robust approach to examining the longitudinal relationships between loneliness and problematic media use. To address these limitations, the current meta-analysis aims to (1) examine the longitudinal relationship between loneliness and problematic media use based on other statistical analyses and (2) explore potential moderators that might influence the strength of the longitudinal relationships.</p></sec></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Overview</title><p>The current meta-analysis was conducted following the standards specified in the updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)  2020 guidelines [<xref ref-type="bibr" rid="ref26">26</xref>]. This study protocol was preregistered in the Open Science Framework (OSF) Registry on January 17, 2024.</p></sec><sec id="s2-2"><title>Search Strategy</title><p>A literature search was performed on January 24, 2024, in 3 online databases, namely Scopus, APA PsycArticles, and PubMed. The following search terms were used as keywords: loneliness AND (internet OR &#x201C;social media&#x201D; OR &#x201C;social network&#x201D; OR gam* OR smartphone) AND (addict* OR disorder OR problem* OR excessive OR patholog*) AND (longitudinal OR prospective). In addition, the gray literature was searched by reviewing the references of included studies.</p></sec><sec id="s2-3"><title>Study Inclusion and Exclusion Criteria</title><p>The studies were screened in 2 stages by 2 independent researchers. First, duplicate papers were removed, and the remaining papers were screened based on their titles and abstracts to identify potentially relevant studies. In the second stage, the full texts of the shortlisted papers were reviewed for eligibility (<xref ref-type="other" rid="box1">Textbox 1</xref>).</p><boxed-text id="box1"><title>  Inclusion and exclusion criteria.</title><p><bold>Inclusion criteria:</bold></p><list list-type="bullet"><list-item><p>Written in English.</p></list-item><list-item><p>Published in a peer-reviewed journal.</p></list-item><list-item><p>Reported estimates of the longitudinal relationship between loneliness and problematic media use (eg, reported as correlation coefficient, path coefficient, beta coefficient, odds ratio, or Cohen d; problematic media use included internet gaming disorder, social media disorder, internet addiction, or smartphone addiction).</p></list-item><list-item><p> A longitudinal study.</p></list-item></list><p><bold>Exclusion criteria:</bold></p><list list-type="bullet"><list-item><p>Focused on gambling disorder or gambling-related behavior (eg, loot boxes).</p></list-item><list-item><p>Did not include measures of loneliness and problematic media use as the investigated variables.</p></list-item><list-item><p>Were case studies or qualitative studies.</p></list-item><list-item><p>Focused exclusively on the therapeutic aspects of problematic media use (ie, randomized controlled trial of cognitive behavioral therapy).</p></list-item><list-item><p>Were preprints, dissertations and theses, conference proceedings and abstracts, or government/industry reports.</p></list-item></list></boxed-text></sec><sec id="s2-4"><title>Data Extraction</title><p>The following information was extracted from the studies by 2 independent researchers: (1) sample size, (2) study location, (3) age, (4) gender ratio, (5) type of problematic media use recorded, (6) measures of loneliness, (7) measures of problematic media use, (8) number of waves, (9) time lag, and (10) effect size. Any discrepancies during the data extraction process were resolved through discussion.</p><p>To investigate the bidirectional relationship between loneliness and problematic media use, 3 effect sizes were recorded whenever possible. First, Pearson correlation coefficients between variables at different time points were documented (eg, the relationship between loneliness at Time 1 and problematic media use at Time 2). If a study reported an effect size other than Pearson <italic>r</italic> (eg, odds ratio), the result was converted into a correlation coefficient using widely accepted formulae [<xref ref-type="bibr" rid="ref27">27</xref>]. Second, standardized beta coefficients from various statistical models were collected (eg, multiple regression and cross-lagged models). Third, standardized beta coefficients were computed using the following equation [<xref ref-type="bibr" rid="ref28">28</xref>]:</p><disp-formula id="equWL1"><mml:math id="eqn1"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:msub><mml:mi>&#x03B2;</mml:mi><mml:mrow><mml:mi>Y</mml:mi><mml:mn>1.2</mml:mn></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:msub><mml:mi>r</mml:mi><mml:mrow><mml:mi>Y</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:msub><mml:mo>&#x2212;</mml:mo><mml:msub><mml:mi>r</mml:mi><mml:mrow><mml:mi>Y</mml:mi><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mi>r</mml:mi><mml:mrow><mml:mn>12</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mo>&#x2212;</mml:mo><mml:msubsup><mml:mi>r</mml:mi><mml:mrow><mml:mn>12</mml:mn></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msubsup></mml:mrow></mml:mfrac></mml:mrow></mml:mstyle></mml:math></disp-formula><p>To provide further clarity, <inline-formula><mml:math id="ieqn7"><mml:msub><mml:mrow><mml:mi>&#x03B2;</mml:mi></mml:mrow><mml:mrow><mml:mi>Y</mml:mi><mml:mn>1.2</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> represents the standardized beta coefficient denoting the longitudinal relationship between the independent variable  and dependent variable (DV), while controlling for the effect of DV. For instance, it illustrates the effect of loneliness at Time 1 on problematic media use at Time 2, while controlling for the effect of problematic media use at Time 1. Furthermore, <inline-formula><mml:math id="ieqn8"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>Y</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> and <inline-formula><mml:math id="ieqn9"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>Y</mml:mi><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> denote zero-order correlations between the independent variables and DV. For instance, <inline-formula><mml:math id="ieqn10"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>Y</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> signifies the correlation between loneliness at Time 1 and problematic media use at Time 2, whereas <inline-formula><mml:math id="ieqn11"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>Y</mml:mi><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> indicates the correlation between problematic media use at Time 1 and Time 2. Finally, <inline-formula><mml:math id="ieqn12"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>12</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> represents the correlation between loneliness at Time 1 and problematic media use at Time 1.</p><p>In a study that included multiple waves of data, the relationships between the 2 closest time points were extracted (eg,  Time 1 and Time 2;  Time 2 and Time 3).</p></sec><sec id="s2-5"><title>Risk of Bias Assessment of the Studies</title><p>The included studies were assessed for risk of bias based on the Joanna Briggs Institute (JBI) guidelines [<xref ref-type="bibr" rid="ref29">29</xref>]. The studies were independently evaluated  by 2 authors. The risk of bias assessment for longitudinal studies incorporated 11 domains outlined in the JBI Critical Appraisal Checklist for Cohort Studies. Each domain was assessed as having a high (H; scored as 0), low (L; scored as 1), or unclear (NA; excluded from total score) risk of bias. A high risk of bias indicates that the study&#x2019;s methodology might significantly affect the measured outcomes. A low risk of bias implies that the methods met quality requirements. An unclear risk definition was used when there was insufficient information to determine the risk of bias. At the end of the assessment, any discrepancies between the 2 researchers were discussed until a consensus was reached.</p></sec><sec id="s2-6"><title>Statistical Analysis</title><p>The meta-analysis was conducted using the <italic>&#x201C;</italic>meta&#x201D; package in the R software (R Foundation for Statistical Computing) environment [<xref ref-type="bibr" rid="ref30">30</xref>]. We used a random-effects model to compare effect sizes, assuming heterogeneity between samples. Three meta-analyses were conducted separately for the 3 types of effect sizes, accompanied by 95% prediction intervals [<xref ref-type="bibr" rid="ref31">31</xref>]. Heterogeneity was quantified using the restricted maximum likelihood estimator and I<sup>2</sup>  statistic. I<sup>2</sup> values between 50% and 75% indicate moderate heterogeneity, while values above 75% reflect high heterogeneity [<xref ref-type="bibr" rid="ref32">32</xref>].</p><p>To delve deeper into the longitudinal relationships between loneliness and problematic media use, subgroup analyses were conducted to identify potential moderators. We delineated five subgroups: type of problematic media use (categorized as gaming, internet, smartphone, and social media), geographical region (categorized as Asia, Europe, and North America), lag length in months (categorized as lag &#x2264;3, 3&#x003C; lag &#x2264;6, and lag &#x003E;6), measure of problematic media use (categorized as validated, Diagnostic and Statistical Manual of Mental Disorders [DSM] criteria-based, and adapted measures), and measure of loneliness (categorized as validated and adapted measures). Although we recorded the specific measures of loneliness and problematic media use for each study, it is noteworthy that certain measures were infrequently used across studies (eg, Generalized Problematic Internet Use Scale [GPIUS]). Consequently, this scarcity hindered our ability to generate meaningful comparisons within these specific measures.</p><p>Finally, contour-enhanced funnel plots were generated to visually inspect for potential publication bias. Egger regression tests were conducted to provide a more robust statistical evaluation of funnel plot asymmetry. In addition, the correlation between sample size and effect size was examined, with a negative correlation indicating potential publication bias [<xref ref-type="bibr" rid="ref33">33</xref>].</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Screening and Selection Process</title><p>A total of 2731 records were retrieved from  3 online databases (APA PsycArticles=2408, PubMed=128, and Scopus=195). After  removing 97 duplicated papers, 2634 records remained and were screened based on titles and abstracts. Of these, 2590 papers were further excluded. The remaining 44 papers, along with key studies identified through manual searches in the reference list, were selected for full-text review. Finally, a total of 26 relevant studies were included for the meta-analysis (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Flowchart of the data screening process.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v27i1e60410_fig01.png"/></fig></sec><sec id="s3-2"><title>Descriptive Characteristics of the Selected</title><p>A summary of the included studies was presented in <xref ref-type="table" rid="table1">Table 1</xref>. The 26 studies involve a total of 24,798 individuals from diverse backgrounds, ranging from adolescents [<xref ref-type="bibr" rid="ref34">34</xref>] to smartphone users in the general population [<xref ref-type="bibr" rid="ref18">18</xref>].</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Summary of studies included in the meta-analysis.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study and reference</td><td align="left" valign="bottom">Country (region)</td><td align="left" valign="bottom">Population</td><td align="left" valign="bottom">Sample size (n)</td><td align="left" valign="bottom">Media</td><td align="left" valign="bottom">PMU<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> measure</td><td align="left" valign="bottom">Loneliness measure</td></tr></thead><tbody><tr><td align="left" valign="top">Fang et al [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">Middle school students</td><td align="left" valign="top">677</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>PIUS<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></p></list-item></list></td><td align="left" valign="top">UCLA 3<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td></tr><tr><td align="left" valign="top">Finser&#x00E5;s et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">Norway (Europe)</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">1258</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p><italic>DSM-5</italic> IGD<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></p></list-item></list></td><td align="left" valign="top">RULS-8<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Gao et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">Undergraduates</td><td align="left" valign="top">367</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>OGAS<sup><xref ref-type="table-fn" rid="table1fn6">f</xref></sup></p></list-item></list></td><td align="left" valign="top">ULS-8<sup><xref ref-type="table-fn" rid="table1fn7">g</xref></sup></td></tr><tr><td align="left" valign="top">Gao et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">Freshman</td><td align="left" valign="top">319</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>OGAS</p></list-item></list></td><td align="left" valign="top">ULS-8</td></tr><tr><td align="left" valign="top">Hu and Xiang [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">906</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">Adapted</td></tr><tr><td align="left" valign="top">Jia et al [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">First-year university students</td><td align="left" valign="top">361</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT<sup><xref ref-type="table-fn" rid="table1fn8">h</xref></sup></p></list-item></list></td><td align="left" valign="top">UCLA<sup><xref ref-type="table-fn" rid="table1fn9">i</xref></sup></td></tr><tr><td align="left" valign="top">Karsay et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">Germany (Europe)</td><td align="left" valign="top">Smartphone users</td><td align="left" valign="top">461</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">Adapted</td></tr><tr><td align="left" valign="top">Kim [<xref ref-type="bibr" rid="ref16">16</xref>]</td><td align="left" valign="top">Korea (Asia)</td><td align="left" valign="top">Smartphone users</td><td align="left" valign="top">288</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">UCLA 3</td></tr><tr><td align="left" valign="top">Krossbakken et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">Norway (Europe)</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">1277</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>GAS<sup><xref ref-type="table-fn" rid="table1fn10">j</xref></sup></p></list-item></list></td><td align="left" valign="top">RULS-8</td></tr><tr><td align="left" valign="top">Lapierre et al [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">United States (North America)</td><td align="left" valign="top">Late adolescents</td><td align="left" valign="top">346</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>SPS<sup><xref ref-type="table-fn" rid="table1fn11">k</xref></sup></p></list-item></list></td><td align="left" valign="top">ULS-8</td></tr><tr><td align="left" valign="top">Lemmens et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">Netherlands (Europe)</td><td align="left" valign="top">Game-playing adolescents</td><td align="left" valign="top">543</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>GAS</p></list-item></list></td><td align="left" valign="top">UCLA 3</td></tr><tr><td align="left" valign="top">Mun [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">Korea (Asia)</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">393</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">Adapted</td></tr><tr><td align="left" valign="top">Ok [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">Korea (Asia)</td><td align="left" valign="top">Students</td><td align="left" valign="top">529</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">Olsen et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">Norway (Europe)</td><td align="left" valign="top">Individuals in military service</td><td align="left" valign="top">258</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>GAS</p></list-item></list></td><td align="left" valign="top">RULS-8</td></tr><tr><td align="left" valign="top">Reed et al - study 2 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">United Kingdom (Europe)</td><td align="left" valign="top">University students</td><td align="left" valign="top">32</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">Reed et al - study 2 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">United Kingdom (Europe)</td><td align="left" valign="top">University students</td><td align="left" valign="top">41</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">Rogier et al [<xref ref-type="bibr" rid="ref15">15</xref>]</td><td align="left" valign="top">Italy (Europe)</td><td align="left" valign="top">Adults</td><td align="left" valign="top">308</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Gaming</p></list-item><list-item><p>Social media</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IGDS9-SF<sup><xref ref-type="table-fn" rid="table1fn12">l</xref></sup></p></list-item><list-item><p>BSMAS<sup><xref ref-type="table-fn" rid="table1fn13">m</xref></sup></p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">Shi [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">College students</td><td align="left" valign="top">3827</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>SAS-SV<sup><xref ref-type="table-fn" rid="table1fn14">n</xref></sup></p></list-item></list></td><td align="left" valign="top">ULS-8<sup><xref ref-type="table-fn" rid="table1fn15">o</xref></sup></td></tr><tr><td align="left" valign="top">Tian [<xref ref-type="bibr" rid="ref44">44</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">University students</td><td align="left" valign="top">291</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">Tian [<xref ref-type="bibr" rid="ref45">45</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">Junior middle school students</td><td align="left" valign="top">1047</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA</td></tr><tr><td align="left" valign="top">T&#x00F3;th&#x2010;Kir&#x00E1;ly [<xref ref-type="bibr" rid="ref46">46</xref>]</td><td align="left" valign="top">Finland (Europe)</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">1736</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">Adapted</td></tr><tr><td align="left" valign="top">Wang [<xref ref-type="bibr" rid="ref47">47</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">University freshmen and sophomores</td><td align="left" valign="top">7434</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Smartphone</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>SAS-SV</p></list-item></list></td><td align="left" valign="top">ULS-8</td></tr><tr><td align="left" valign="top">Wang [<xref ref-type="bibr" rid="ref48">48</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">6th-grade students</td><td align="left" valign="top">296</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>GPIUS<sup><xref ref-type="table-fn" rid="table1fn16">p</xref></sup></p></list-item></list></td><td align="left" valign="top">UCLA 3</td></tr><tr><td align="left" valign="top">Wu [<xref ref-type="bibr" rid="ref49">49</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">University students</td><td align="left" valign="top">538</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>PMSMUAS<sup><xref ref-type="table-fn" rid="table1fn17">q</xref></sup></p></list-item></list></td><td align="left" valign="top">UCLA 3</td></tr><tr><td align="left" valign="top">Yao [<xref ref-type="bibr" rid="ref50">50</xref>]</td><td align="left" valign="top">United States (North America)</td><td align="left" valign="top">College freshmen</td><td align="left" valign="top">219</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Adapted</p></list-item></list></td><td align="left" valign="top">SLS<sup><xref ref-type="table-fn" rid="table1fn18">r</xref></sup></td></tr><tr><td align="left" valign="top">Yang [<xref ref-type="bibr" rid="ref51">51</xref>]</td><td align="left" valign="top">Hong Kong (Asia)</td><td align="left" valign="top">College students</td><td align="left" valign="top">361</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Internet</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>IAT</p></list-item></list></td><td align="left" valign="top">UCLA 3</td></tr><tr><td align="left" valign="top">Zhou [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">China (Asia)</td><td align="left" valign="top">First-year undergraduates</td><td align="left" valign="top">685</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Social media</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>BSMAS</p></list-item></list></td><td align="left" valign="top">ULS-6<sup><xref ref-type="table-fn" rid="table1fn19">s</xref></sup></td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>PMU: problematic media use.</p></fn><fn id="table1fn2"><p><sup>b</sup>PIUS: Pathological Internet Use Scale.</p></fn><fn id="table1fn3"><p><sup>c</sup>UCLA 3: UCLA Loneliness Scale Version 3.</p></fn><fn id="table1fn4"><p><sup>d</sup><italic>DSM-5</italic> IGD: <italic>Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition,</italic> IGD criteria</p></fn><fn id="table1fn5"><p><sup>e</sup>RULS-8: Roberts UCLA Loneliness Scale.</p></fn><fn id="table1fn6"><p><sup>f</sup>OGAS: Online Game Addiction Scale.</p></fn><fn id="table1fn7"><p><sup>g</sup>ULS-8:  Short-Form Loneliness Scale.</p></fn><fn id="table1fn8"><p><sup>h</sup>IAT:  Young&#x2019;s Internet Addiction Test.</p></fn><fn id="table1fn9"><p><sup>i</sup>UCLA:  UCLA Loneliness Scale.</p></fn><fn id="table1fn10"><p><sup>j</sup>GAS:  Game Addiction Scale.</p></fn><fn id="table1fn11"><p><sup>k</sup>SPS:  Smartphone Proneness Scale.</p></fn><fn id="table1fn12"><p><sup>l</sup>IGDS9-SF:  Internet Gaming Disorder Scale&#x2013;Short Form.</p></fn><fn id="table1fn13"><p><sup>m</sup>BSMAS:  Bergen Social Media Addiction Scale.</p></fn><fn id="table1fn14"><p><sup>n</sup>SAS-SV:  Smartphone Addiction Scale&#x2013;Short Version.</p></fn><fn id="table1fn15"><p><sup>o</sup>ULS-8: Short-Form Loneliness Scale.</p></fn><fn id="table1fn16"><p><sup>p</sup>GPIUS: Generalized Problematic Internet Use Scale.</p></fn><fn id="table1fn17"><p><sup>q</sup>PMSMUAS: Problematic Mobile Social Media Usage Assessment Scale for Adolescents.</p></fn><fn id="table1fn18"><p><sup>r</sup>SLS: Short Loneliness Scale.</p></fn><fn id="table1fn19"><p><sup>s</sup>ULS-6:  6-item Chinese version of UCLA Scale.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Risk of Bias Assessment</title><p>The JBI Critical Appraisal Checklist for Cohort Studies was used to evaluate the risk of bias (<xref ref-type="table" rid="table2">Table 2</xref>). The maximum score among the studies was 9 (range 3&#x2010;9). The average quality score in the studies was approximately 7 points. In 23 studies, the methodological quality was at least 50% of the total score. Notably, a high risk of bias was observed in 3 studies [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]. A sensitivity analysis was performed by comparing datasets with and without these 3 studies (findings not reported here). The results of the sensitivity analysis were identical between the 2 datasets. Therefore, the 3 studies were retained in the analysis for better coverage.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Summary of quality appraisal based on the Joanna Briggs Institute Critical Appraisal Checklist for Cohort Studies. The maximum score and appropriate appraisal for cohort studies were used with 11 criteria.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study and reference</td><td align="left" valign="bottom">1</td><td align="left" valign="bottom">2</td><td align="left" valign="bottom">3</td><td align="left" valign="bottom">4</td><td align="left" valign="bottom">5</td><td align="left" valign="bottom">6</td><td align="left" valign="bottom">7</td><td align="left" valign="bottom">8</td><td align="left" valign="bottom">9</td><td align="left" valign="bottom">10</td><td align="left" valign="bottom">11</td><td align="left" valign="bottom">Total</td></tr></thead><tbody><tr><td align="left" valign="top">Fang et al [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">H<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td><td align="left" valign="top">L<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup></td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Finser&#x00E5;s et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Gao et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Gao et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Hu and Xiang [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">5/9</td></tr><tr><td align="left" valign="top">Jia et al [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Karsay et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Kim [<xref ref-type="bibr" rid="ref16">16</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Krossbakken et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">9/9</td></tr><tr><td align="left" valign="top">Lapierre et al [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">3/9</td></tr><tr><td align="left" valign="top">Lemmens et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr><tr><td align="left" valign="top">Mun [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr><tr><td align="left" valign="top">Ok [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Olsen et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Reed et al - study 1 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">H</td><td align="left" valign="top">4/9</td></tr><tr><td align="left" valign="top">Reed et al - study 2 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">H</td><td align="left" valign="top">4/9</td></tr><tr><td align="left" valign="top">Rogier et al [<xref ref-type="bibr" rid="ref15">15</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr><tr><td align="left" valign="top">Shi et al [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr><tr><td align="left" valign="top">Tian et al [<xref ref-type="bibr" rid="ref44">44</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">6/9</td></tr><tr><td align="left" valign="top">Tian et al [<xref ref-type="bibr" rid="ref45">45</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">T&#x00F3;th&#x2010;Kir&#x00E1;ly et al [<xref ref-type="bibr" rid="ref46">46</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">9/9</td></tr><tr><td align="left" valign="top">Wang et al [<xref ref-type="bibr" rid="ref47">47</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">9/9</td></tr><tr><td align="left" valign="top">Wang et al [<xref ref-type="bibr" rid="ref48">48</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Wu et al [<xref ref-type="bibr" rid="ref49">49</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr><tr><td align="left" valign="top">Yao and Zhong [<xref ref-type="bibr" rid="ref50">50</xref>]</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">3/9</td></tr><tr><td align="left" valign="top">Yang et al [<xref ref-type="bibr" rid="ref51">51</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">H</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">8/9</td></tr><tr><td align="left" valign="top">Zhou et al [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">H</td><td align="left" valign="top">H</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">L</td><td align="left" valign="top">NA</td><td align="left" valign="top">L</td><td align="left" valign="top">7/9</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>H: high risk of bias (scored as 0).</p></fn><fn id="table2fn2"><p><sup>b</sup>L: low risk of bias (scored as 1).</p></fn><fn id="table2fn3"><p><sup>c</sup>NA: not applicable (excluded from the total score).</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-4"><title>Longitudinal Relationship From Loneliness to Problematic Media Use</title><p>Based on the random-effects model, a significant relationship was observed between loneliness at Time 1 and problematic media use at Time 2 (refer to <xref ref-type="table" rid="table3">Table 3</xref>). Specifically, the strength of this relationship was notably higher when examined using the Pearson correlation coefficient (<italic>r</italic>=0.28, 95% CI 0.25-0.31; prediction interval 0.11-0.44) compared with other research models (<italic>r</italic>=0.10, 95% CI 0.08-0.13; prediction interval &#x2212;0.02 to 0.23) and estimated beta coefficients (<italic>r</italic>=0.10, 95% CI 0.09-0.12; prediction interval 0.05-0.16).</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Longitudinal relationship from loneliness to problematic media use.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Moderator</td><td align="left" valign="bottom" colspan="6">Pearson</td><td align="left" valign="bottom" colspan="6">Model</td><td align="left" valign="bottom" colspan="6">Estimated</td></tr></thead><tbody><tr><td align="left" valign="top"/><td align="left" valign="top"><italic>k<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top"><italic>k</italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top"><italic>k</italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Overall</td><td align="left" valign="top">33</td><td align="left" valign="top">0.28 (0.25-0.31)</td><td align="left" valign="top">0.09</td><td align="left" valign="top">86.1</td><td align="char" char="." valign="top">105.59</td><td align="char" char="." valign="top">&#x003C;.001</td><td align="left" valign="top">32</td><td align="left" valign="top">0.10 (0.08-0.13)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">68.8</td><td align="char" char="." valign="top">105.59</td><td align="char" char="." valign="top">&#x003C;.001</td><td align="left" valign="top">28</td><td align="left" valign="top">0.10 (0.09-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">38.6</td><td align="char" char="." valign="top">105.59</td><td align="char" char="." valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top" colspan="5">Type of PMU<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup></td><td align="char" char="." valign="top">28.55</td><td align="char" char="." valign="top">&#x003C;.001</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.55</td><td align="char" char="." valign="top">.91</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">16.58</td><td align="char" char="." valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Social media</td><td align="left" valign="top">6</td><td align="left" valign="top">0.26 (0.18-0.33)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">78.4</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.12 (0.03-0.22)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">82.7</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.09 (0.03-0.15)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">61.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Smartphone</td><td align="left" valign="top">8</td><td align="left" valign="top">0.36 (0.33-0.40)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">81.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.09 (0.07-0.11)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">8</td><td align="left" valign="top">0.13 (0.12-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Internet</td><td align="left" valign="top">11</td><td align="left" valign="top">0.24 (0.21-0.26)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">11</td><td align="left" valign="top">0.09 (0.06-0.13)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">62.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">11</td><td align="left" valign="top">0.08 (0.05-0.10)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Gaming</td><td align="left" valign="top">8</td><td align="left" valign="top">0.26 (0.19-0.33)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">75.2</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">11</td><td align="left" valign="top">0.11 (0.05-0.16)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">78.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.09 (0.04-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Country</td><td align="char" char="." valign="top">7.69</td><td align="char" char="." valign="top">.02</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.64</td><td align="char" char="." valign="top">.73</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.36</td><td align="char" char="." valign="top">.83</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Asia</td><td align="left" valign="top">27</td><td align="left" valign="top">0.30 (0.27-0.33)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">85.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">19</td><td align="left" valign="top">0.11 (0.07-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">67.7</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">24</td><td align="left" valign="top">0.10 (0.08-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">45.8</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Europe</td><td align="left" valign="top">4</td><td align="left" valign="top">0.20 (0.12-0.28)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">54.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">12</td><td align="left" valign="top">0.10 (0.06-0.15)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">73.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">2</td><td align="left" valign="top">0.11 (0.04- 0.18)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>North America</td><td align="left" valign="top">2</td><td align="left" valign="top">0.19 (0.06-0.31)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">58.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">0.06 (&#x2212;0.05 to 0.16)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">2</td><td align="left" valign="top">0.08 (&#x2212;0.00 to 0.16)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Lag length (month)</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="char" char="." valign="top">2.76</td><td align="char" char="." valign="top">.25</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="char" char="." valign="top">7.60</td><td align="char" char="." valign="top">.02</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="char" char="." valign="top">0.66</td><td align="char" char="." valign="top">.72</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Lag &#x2264;3</td><td align="left" valign="top">6</td><td align="left" valign="top">0.26 (0.22-0.30)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">8</td><td align="left" valign="top">0.18 (0.12-0.24)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">57.6</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">3</td><td align="left" valign="top">0.08 (0.02-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>3&#x003C; lag &#x2264;6</td><td align="left" valign="top">15</td><td align="left" valign="top">0.31 (0.26-0.36)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">87.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">10</td><td align="left" valign="top">0.08 (0.05-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">57.1</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">13</td><td align="left" valign="top">0.10 (0.08-0.13)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">61.1</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Lag &#x003E;6</td><td align="left" valign="top">12</td><td align="left" valign="top">0.26 (0.21-0.31)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">72.8</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">14</td><td align="left" valign="top">0.09 (0.05-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">72.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">12</td><td align="left" valign="top">0.10 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Measure of PMU</td><td align="char" char="." valign="top">0.76</td><td align="char" char="." valign="top">.38</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">8.15</td><td align="char" char="." valign="top">.02</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.08</td><td align="char" char="." valign="top">.78</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Validated</td><td align="left" valign="top">28</td><td align="left" valign="top">0.28 (0.25-0.31)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">86.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">26</td><td align="left" valign="top">0.10 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">64.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">23</td><td align="left" valign="top">0.10 (0.08-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">46.2</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>DSM<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup> criteria</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">0.02 (&#x2013;0.04 to 0.07)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Adapted</td><td align="left" valign="top">5</td><td align="left" valign="top">0.33 (0.21-0.44)</td><td align="left" valign="top">0.02</td><td align="left" valign="top">84.1</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.14 (0.06-0.22)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">78.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.10 (0.06-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Measure of loneliness</td><td align="char" char="." valign="top">2.50</td><td align="char" char="." valign="top">.11</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">1.25</td><td align="char" char="." valign="top">.26</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.13</td><td align="char" char="." valign="top">.72</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Validated</td><td align="left" valign="top">30</td><td align="left" valign="top">0.28 (0.25-0.31)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">87.3</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">28</td><td align="left" valign="top">0.09 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">64.8</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">25</td><td align="left" valign="top">0.10 (0.09-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">41.5</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Adapted</td><td align="left" valign="top">3</td><td align="left" valign="top">0.33 (0.28-0.37)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">10.7</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.15 (0.05-0.24)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">83.4</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">3</td><td align="left" valign="top">0.09 (0.05-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup><italic>k</italic>: number of estimates.</p></fn><fn id="table3fn2"><p><sup>b</sup>PMU: problematic media use.</p></fn><fn id="table3fn3"><p><sup>c</sup><italic>DSM</italic>: <italic>Diagnostic and Statistical Manual of Mental Disorders.</italic></p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-5"><title>Longitudinal Relationship From Problematic Media Use to Loneliness</title><p>A significant relationship was observed between problematic media use at Time 1 and loneliness at Time 2 (<xref ref-type="table" rid="table4">Table 4</xref>). Similar to the other direction, the relationship is significantly stronger when examined using the Pearson correlation coefficient (<italic>r</italic>=0.29, 95% CI 0.26-0.32; prediction interval 0.13-0.43) compared with other research models (<italic>r</italic>=0.13, 95% CI 0.07-0.13; prediction interval &#x2212;0.02 to 0.23) and estimated beta coefficients (<italic>r</italic>=0.09, 95% CI 0.07-0.11; prediction interval 0.01-0.16).</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>Longitudinal relationship from problematic media use to loneliness.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Moderator</td><td align="left" valign="bottom" colspan="4">Pearson</td><td align="left" valign="bottom"/><td align="left" valign="bottom"/><td align="left" valign="bottom" colspan="4">Model</td><td align="left" valign="bottom"/><td align="left" valign="bottom"/><td align="left" valign="bottom" colspan="4">Estimated</td><td align="left" valign="bottom"/><td align="left" valign="bottom"/></tr></thead><tbody><tr><td align="left" valign="top"/><td align="left" valign="top"><italic>k<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup></italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top"><italic>k</italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top"><italic>k</italic></td><td align="left" valign="top"><italic>r</italic> (95% CI)</td><td align="left" valign="top"><italic>&#x03C4;</italic><sup>2</sup></td><td align="left" valign="top"><italic>I</italic><sup>2</sup></td><td align="left" valign="top">Q value</td><td align="left" valign="top"><italic>P</italic> value</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Overall</td><td align="left" valign="top">27</td><td align="left" valign="top">0.29 (0.26-0.32)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">85.2</td><td align="char" char="." valign="top">110.13</td><td align="char" char="." valign="top">&#x003C;.001</td><td align="left" valign="top">23</td><td align="left" valign="top">0.10 (0.07-0.13)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">73.3</td><td align="char" char="." valign="top">110.13</td><td align="char" char="." valign="top">&#x003C;.001</td><td align="left" valign="top">27</td><td align="left" valign="top">0.09 (0.07-0.11)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">52.9</td><td align="char" char="." valign="top">110.13</td><td align="char" char="." valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top" colspan="5">Type of PMU<sup><xref ref-type="table-fn" rid="table4fn2">b</xref></sup></td><td align="char" char="." valign="top">4.18</td><td align="char" char="." valign="top">.24</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">3.75</td><td align="char" char="." valign="top">.29</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">1.86</td><td align="char" char="." valign="top">.60</td></tr><tr><td align="left" valign="top">Social media</td><td align="left" valign="top">4</td><td align="left" valign="top">0.32 (0.21-0.41)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">87.2</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.08 (0.03-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.08 (0.04-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Smartphone</td><td align="left" valign="top">9</td><td align="left" valign="top">0.31 (0.27-0.36)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">86.7</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.09 (0.03-0.15)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">70.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">9</td><td align="left" valign="top">0.08 (0.07-0.09)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">9.9</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Internet</td><td align="left" valign="top">11</td><td align="left" valign="top">0.25 (0.20-0.29)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">65.8</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">9</td><td align="left" valign="top">0.23 (0.07-0.39)</td><td align="left" valign="top">0.06</td><td align="left" valign="top">86.8</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">11</td><td align="left" valign="top">0.12 (0.06-0.18)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">75.7</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Gaming</td><td align="left" valign="top">3</td><td align="left" valign="top">0.30 (0.18-0.41)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">82.8</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.07 (0.05- 0.10)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">3</td><td align="left" valign="top">0.10 (0.05-0.15)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Country</td><td align="char" char="." valign="top">10.70</td><td align="char" char="." valign="top">.00</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">2.05</td><td align="char" char="." valign="top">.36</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.09</td><td align="char" char="." valign="top">.95</td></tr><tr><td align="left" valign="top">Asia</td><td align="left" valign="top">24</td><td align="left" valign="top">0.30 (0.26-0.33)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">85.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">14</td><td align="left" valign="top">0.09 (0.06-0.12)</td><td align="left" valign="top">.00</td><td align="left" valign="top">61.4</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">24</td><td align="left" valign="top">0.09 (0.07-0.11)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">57.6</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Europe</td><td align="left" valign="top">2</td><td align="left" valign="top">0.19 (0.12-0.24)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">8</td><td align="left" valign="top">0.23 (0.04-0.41)</td><td align="left" valign="top">.08</td><td align="left" valign="top">85.5</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">2</td><td align="left" valign="top">0.08 (0.02-0.14)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">North America</td><td align="left" valign="top">1</td><td align="left" valign="top">0.25 (0.15-0.35)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">0.08 (&#x2013;0.03 to 0.18)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">0.08 (&#x2013;0.03 to 0.18)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Lag length (month)</td><td align="char" char="." valign="top">1.13</td><td align="char" char="." valign="top">.57</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">9.74</td><td align="char" char="." valign="top">.01</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">1.26</td><td align="char" char="." valign="top">.53</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Lag &#x2264;3</td><td align="left" valign="top">3</td><td align="left" valign="top">0.27 (0.15-0.38)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">76.6</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.40 (0.02-0.68)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">62.1</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">3</td><td align="left" valign="top">0.14 (&#x2013;0.02 to 0.29)</td><td align="left" valign="top">0.02</td><td align="left" valign="top"><italic>85.5</italic></td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x2003; </named-content>3&#x003C; lag &#x2264;6</td><td align="left" valign="top">13</td><td align="left" valign="top">0.30 (0.26-0.35)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">85.2</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">9</td><td align="left" valign="top">0.12 (0.08-0.17)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">62.1</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">13</td><td align="left" valign="top">0.09 (0.07-0.10)</td><td align="left" valign="top">0.00</td><td align="left" valign="top"><italic>52.4</italic></td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Lag  &#x003E;6</td><td align="left" valign="top">11</td><td align="left" valign="top">0.27 (0.22-0.32)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">80.0</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">10</td><td align="left" valign="top">0.16 (0.04-0.08)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">35.7</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">11</td><td align="left" valign="top">0.07 (0.04-0.10)</td><td align="left" valign="top">0.00</td><td align="left" valign="top"><italic>14.8</italic></td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Measure of PMU</td><td align="char" char="." valign="top">0.05</td><td align="char" char="." valign="top">.83</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.02</td><td align="char" char="." valign="top">.88</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">3.27</td><td align="char" char="." valign="top">.07</td></tr><tr><td align="left" valign="top">Validated</td><td align="left" valign="top">22</td><td align="left" valign="top">0.29 (0.25-0.32)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">86.2</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">21</td><td align="left" valign="top">0.10 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">70.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">22</td><td align="left" valign="top">0.10 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">58.1</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Adapted</td><td align="left" valign="top">5</td><td align="left" valign="top">0.30 (0.21-0.37)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">78.1</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">2</td><td align="left" valign="top">0.11 (&#x2013;0.09 to 0.31)</td><td align="left" valign="top">0.02</td><td align="left" valign="top">92.6</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">5</td><td align="left" valign="top">0.05 (0.01-0.09)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5">Measure of loneliness</td><td align="char" char="." valign="top">.08</td><td align="char" char="." valign="top">.78</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">0.02</td><td align="char" char="." valign="top">.88</td><td align="left" valign="top" colspan="4"/><td align="char" char="." valign="top">2.15</td><td align="char" char="." valign="top">.14</td></tr><tr><td align="left" valign="top">Validated</td><td align="left" valign="top">23</td><td align="left" valign="top">0.29 (0.25-0.32)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">85.6</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">21</td><td align="left" valign="top">0.10 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">70.9</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">23</td><td align="left" valign="top">0.09 (0.07-0.12)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">57.3</td><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">Adapted</td><td align="left" valign="top">4</td><td align="left" valign="top">0.28 (0.19-0.36)</td><td align="left" valign="top">0.01</td><td align="left" valign="top">78.3</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">2</td><td align="left" valign="top">0.11 (&#x2013;0.09 to 0.31)</td><td align="left" valign="top">0.02</td><td align="left" valign="top">92.6</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">4</td><td align="left" valign="top">0.06 (0.02-0.10)</td><td align="left" valign="top">0.00</td><td align="left" valign="top">0.0</td><td align="left" valign="top"/><td align="left" valign="top"/></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>k: number of estimates.</p></fn><fn id="table4fn2"><p><sup>b</sup>PMU: problematic media use.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-6"><title>Subgroup Analysis</title><p>When examining the relationship using Pearson correlation coefficients, we found that country acted as a significant moderator for the longitudinal relationship in both directions, particularly showing stronger relationships in the Asian region (loneliness &#x2192; problematic media use: <italic>Q</italic>=7.69; <italic>P</italic>=.02 and problematic media use &#x2192; loneliness: <italic>Q</italic>=10.70; <italic>P</italic>=.01). On the other hand, the type of problematic media use also acted as a significant moderator in the longitudinal relationship from loneliness to problematic media use, with a stronger relationship in the case of smartphone addiction (<italic>Q</italic>=28.5; <italic>P</italic>&#x003C;.001).</p><p>In contrast, the majority of subgroup analyses based on research models and estimated beta coefficients did not yield significant results, suggesting a high level of stability in the findings across the 2 methods. While problematic media use emerged as a significant moderator when examining the relationship with beta coefficients from various statistical models, it is important to note that only 1 study used DSM criteria to measure problematic media use [<xref ref-type="bibr" rid="ref35">35</xref>]. Exploratory data analysis with the exclusion of this study revealed a nonsignificant moderating effect with regard to the measure of problematic media use (finding is not shown in this paper). Overall, the subgroup analyses provide general support for the bidirectional relationship between loneliness and problematic media use.</p></sec><sec id="s3-7"><title>Publication Bias</title><p>Contour-enhanced funnel plots and Egger regression test were performed separately for the 2 causal directions to identify potential publication bias. The funnel plot for the direction of loneliness to problematic media use was asymmetrical (<xref ref-type="fig" rid="figure2">Figure 2</xref>), with a bias estimate of &#x2212;1.55, <italic>t</italic><sub>26</sub>=&#x2212;4.94; <italic>P</italic>&#x003C;.001. It is noteworthy that studies with lower SEs scatter in the middle of the funnel plot, while studies with larger SEs generally scatter around the left side of the funnel plot. Additional analysis revealed a nonsignificant relationship between sample size and effect size, <italic>r</italic>(91)=0.135, 95% CI &#x2212;0.070 to 0.330; <italic>P</italic>=.20.</p><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Funnel plot for studies examining the longitudinal relationship from loneliness to problematic media use.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v27i1e60410_fig02.png"/></fig><p>On the other hand, the funnel plot for the direction of problematic media use to loneliness is symmetrical (<xref ref-type="fig" rid="figure3">Figure 3</xref>), with a bias estimate of 0.32, <italic>t</italic><sub>25</sub>=0.62; <italic>P</italic>=.54. Additional analysis revealed a nonsignificant relationship between sample size and effect size, with <italic>r</italic>(75)=&#x2212;0.004,  95% CI &#x2212;0.228 to 0.220; <italic>P</italic>=.97). These results generally suggest a low risk of publication bias.</p><fig position="float" id="figure3"><label>Figure 3.</label><caption><p>Funnel plot for studies examining the longitudinal relationship from problematic media use to loneliness.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="jmir_v27i1e60410_fig03.png"/></fig></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>Using a random-effects model, the current meta-analysis synthesized the longitudinal relationships between loneliness and problematic media use. Given the contrasting perspectives on the direction of causality, 2 separate analyses were carried out for both directions. Three types of effect sizes were extracted from 26 longitudinal studies: Pearson correlation coefficients, standardized beta coefficients from various statistical models, and estimated beta coefficients based on Cohen et al&#x2019;s [<xref ref-type="bibr" rid="ref28">28</xref>] formula.</p></sec><sec id="s4-2"><title>Longitudinal Relationships Between Loneliness and Problematic Media Use</title><p>Regardless of the type of effect size, the results consistently revealed significant longitudinal relationships between loneliness and problematic media use in both directions. The findings support a bidirectional model where loneliness and problematic media use can influence each other over time. Consistent with the compensatory internet use theory [<xref ref-type="bibr" rid="ref17">17</xref>], lonely individuals may initially use the internet to fulfill unmet social needs, finding temporary relief through online connection. These individuals might become increasingly dependent on the internet to fulfill their social needs, resulting in problematic media use [<xref ref-type="bibr" rid="ref52">52</xref>]. Conversely, as highlighted in the internet paradox [<xref ref-type="bibr" rid="ref5">5</xref>], excessive internet use can displace real-world interactions and weaken social skills. In addition, the quality of online interactions may not fully satisfy social needs, leading to a sense of loneliness despite being connected online.</p></sec><sec id="s4-3"><title>Explaining Heterogeneity</title><p>This meta-analysis revealed a medium effect size when examining longitudinal relationships with Pearson correlation coefficients (<inline-formula><mml:math id="ieqn13"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>L</mml:mi><mml:mi>P</mml:mi><mml:mi>I</mml:mi><mml:mi>U</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.28; <inline-formula><mml:math id="ieqn14"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mi>I</mml:mi><mml:mi>U</mml:mi><mml:mi>L</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> =0.29). This finding aligns with a previous meta-analysis by Zhang et al (<inline-formula><mml:math id="ieqn15"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>L</mml:mi><mml:mi>P</mml:mi><mml:mi>I</mml:mi><mml:mi>U</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=029; <inline-formula><mml:math id="ieqn16"><mml:msub><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mi>I</mml:mi><mml:mi>U</mml:mi><mml:mi>L</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> =0.26) [<xref ref-type="bibr" rid="ref24">24</xref>]. However, the effect sizes were weaker when the relationships were examined using standardized beta coefficients (&#x03B2;=.10; &#x03B2;=.10) or estimated beta coefficients (&#x03B2;=.10; &#x03B2; =.09). This suggests that beta coefficients may provide a more accurate estimate of the longitudinal relationships between loneliness and problematic media use (with narrower CIs), particularly by accounting for the influence of the outcome variable at Time 1.</p><p>Furthermore, both types of beta coefficients exhibit greater stability across diverse study designs compared with Pearson correlation coefficients (eg, geographical region, type of measures, and lag length). Based on these findings, it is recommended for future meta-analyses examining longitudinal relationships to prioritize the use of beta coefficients obtained from robust research models such as cross-lagged models. In addition, individual studies are recommended to report a complete correlation matrix across all variables and time points. These practices would enhance the accuracy and interpretability of findings on longitudinal relationships.</p><p>The estimated 95% prediction intervals indicate that future studies using Pearson correlation coefficients are likely to consistently yield positive longitudinal relationships between loneliness and problematic media use. In contrast, studies using standardized beta coefficients or estimated beta coefficients may produce more variable findings, including potential null or negative relationships. Given the moderate to high heterogeneity reflected by the <italic>I</italic><sup>2</sup> statistic, it is plausible that covariates may influence the observed effect sizes. This study highlights the need for additional longitudinal research from diverse contexts to enhance the robustness of the evidence base and clarify the factors contributing to these relationships. Notably, with approximately 60% of the included studies conducted in Asia, fostering greater international collaboration would provide a more comprehensive understanding and improve generalizability across populations.</p><p>The current findings suggest weaker longitudinal relationships between loneliness and problematic media use compared with those reported by the previous meta-analysis [<xref ref-type="bibr" rid="ref24">24</xref>]. While methodological differences might be the primary cause for the discrepancy, the findings could also be partially explained by the evolving nature of the internet. Kraut et al  [<xref ref-type="bibr" rid="ref53">53</xref>] revisited the internet paradox and found a more positive long-term impact a few years after their initial study, attributing it to technology advancements that facilitated healthier online social interactions. Nearly 2 decades after the study [<xref ref-type="bibr" rid="ref53">53</xref>], the internet offers a wider array of social functions through social media, smartphones, and online gaming. These advancements may have indeed fostered more positive social interaction experiences within online environments [<xref ref-type="bibr" rid="ref54">54</xref>]. For instance, instant messaging allows connection with offline friends, potentially facilitating discussions of more intimate topics [<xref ref-type="bibr" rid="ref55">55</xref>]. Similarly, online and offline gaming communities can connect individuals with similar interests, promoting a sense of belonging. Therefore, the maturing and diverse functionalities of the internet may contribute to healthy friendship formation and maintenance, potentially weakening the longitudinal relationships between loneliness and problematic media use. Future studies could explore specific aspects of the internet (eg, social media features) that foster healthier social interactions.</p><p>Finally, it is important to acknowledge that the current meta-analysis focused on problematic media use (ie, internet gaming disorder, social media disorder, internet addiction, or smartphone addiction). The magnitude of the longitudinal relationships might be stronger if the focus is on general media use. On one hand, loneliness might lead individuals to engage more in online social interactions, but not to the extent of problematic use [<xref ref-type="bibr" rid="ref56">56</xref>]. On the other hand, spending long hours on the internet might result in reduced social interactions and contribute to feelings of loneliness [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. Further complicating the relationship, some studies suggest that internet use can effectively decrease loneliness [<xref ref-type="bibr" rid="ref58">58</xref>]. This highlights the importance of considering the different purposes of internet use beyond solely focusing on symptoms of behavioral addiction. For example, one longitudinal study [<xref ref-type="bibr" rid="ref59">59</xref>] found that the social use of the internet, specifically online interactions with friends and family, can decrease loneliness and increase social engagement. In contrast, informational and instrumental uses, such as browsing news or searching for information, were not related to loneliness. These findings suggest that future research should examine the longitudinal relationships between loneliness and general media use or internet use and explore the potential moderating role of different purposes of internet use.</p></sec><sec id="s4-4"><title>Limitations and Future Directions</title><p>This meta-analysis has several limitations. First, although the contour-enhanced funnel plot and Egger regression test suggest an asymmetrical pattern in studies examining the direction of loneliness to problematic media use, it is notable that the studies seem to be missing in the area of significance (<italic>P</italic>&#x003C;.01). Hence, the asymmetrical pattern might not be the outcome of publication bias or selective nonreporting of results [<xref ref-type="bibr" rid="ref60">60</xref>]. One possible explanation for this outcome is between-study heterogeneity (<italic>I</italic><sup>2</sup>=38.6%); however, more longitudinal studies are needed to confirm this.</p><p>Second, a few studies reported nonsignificant longitudinal relationships without specifying the actual coefficients [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. With the nonsignificant findings primarily found in the cross-lagged model, the actual relationships might be even smaller than the current findings.</p><p>Third, it is important to note that moderate to high heterogeneity was observed in several subgroups. This suggests the presence of additional covariates that were not accounted for in this study. For instance, one of the included studies [<xref ref-type="bibr" rid="ref46">46</xref>] proposed that both social and individual antecedents could influence the relationship, highlighting the need for future research to explore these factors in greater depth.</p><p>Fourth, there are a few studies that met the inclusion criteria but did not report the estimate of the hypothesized longitudinal relationships (most of these studies focused on other relationships). While attempts were made to contact authors for missing data, most did not respond. Finally, the screening process was limited to studies published exclusively in English, potentially excluding valuable information from other linguistic sources.</p></sec><sec id="s4-5"><title>Conclusion</title><p>In conclusion, the findings support a bidirectional model, suggesting that loneliness and problematic media use can influence each other over time. While significant relationships were found in both directions, the effect sizes were weaker than anticipated. This may be partially explained by the evolving nature of the internet, as evidenced by advancements that facilitate healthier online social interactions. In addition, subgroup analyses revealed greater stability in the relationships when examined using beta coefficients, which account for previous outcome variables.</p></sec></sec></body><back><ack><p>This study would not have been possible without the support of Sunway University and Oulu University of Applied Sciences. This study is funded under the Sunway University Research Accelerator Grant Scheme (GRTIN-RAG(02)-DPSY-06&#x2010;2024).</p></ack><notes><sec><title>Data Availability</title><p>The datasets generated during and/or analyzed during this study are available in the Open Science Framework (OSF) Registry.</p></sec></notes><fn-group><fn fn-type="con"><p>All authors were involved in the conceptualization, data curation, formal analysis, methodology development, project administration, drafting of the original manuscript, and reviewing and editing of the final manuscript.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1"><italic>DSM-5</italic></term><def><p><italic>Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition</italic></p></def></def-item><def-item><term id="abb2">DV</term><def><p>dependent variable</p></def></def-item><def-item><term id="abb3">GPIUS</term><def><p>Generalized Problematic Internet Use Scale</p></def></def-item><def-item><term id="abb4">JBI</term><def><p>Joanna Briggs Institute</p></def></def-item><def-item><term id="abb5">OSF</term><def><p>Open Science Framework</p></def></def-item><def-item><term id="abb6">PRISMA</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bargh</surname><given-names>JA</given-names> </name><name name-style="western"><surname>McKenna</surname><given-names>KYA</given-names> </name></person-group><article-title>The internet and social life</article-title><source>Annu Rev Psychol</source><year>2004</year><volume>55</volume><fpage>573</fpage><lpage>590</lpage><pub-id pub-id-type="doi">10.1146/annurev.psych.55.090902.141922</pub-id><pub-id pub-id-type="medline">14744227</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ruckwongpatr</surname><given-names>K</given-names> </name><name name-style="western"><surname>Chirawat</surname><given-names>P</given-names> </name><name name-style="western"><surname>Ghavifekr</surname><given-names>S</given-names> </name><etal/></person-group><article-title>Problematic internet use (PIU) in youth: a brief literature review of selected topics</article-title><source>Curr Opin Behav Sci</source><year>2022</year><month>08</month><volume>46</volume><fpage>101150</fpage><pub-id pub-id-type="doi">10.1016/j.cobeha.2022.101150</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Fineberg</surname><given-names>NA</given-names> </name><name name-style="western"><surname>Demetrovics</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Stein</surname><given-names>DJ</given-names> </name><etal/></person-group><article-title>Manifesto for a European research network into problematic usage of the internet</article-title><source>Eur Neuropsychopharmacol</source><year>2018</year><month>11</month><volume>28</volume><issue>11</issue><fpage>1232</fpage><lpage>1246</lpage><pub-id pub-id-type="doi">10.1016/j.euroneuro.2018.08.004</pub-id><pub-id pub-id-type="medline">30509450</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Pan</surname><given-names>YC</given-names> </name><name name-style="western"><surname>Chiu</surname><given-names>YC</given-names> </name><name name-style="western"><surname>Lin</surname><given-names>YH</given-names> </name></person-group><article-title>Systematic review and meta-analysis of epidemiology of internet addiction</article-title><source>Neuroscience &#x0026; Biobehavioral Reviews</source><year>2020</year><month>11</month><volume>118</volume><fpage>612</fpage><lpage>622</lpage><pub-id pub-id-type="doi">10.1016/j.neubiorev.2020.08.013</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kraut</surname><given-names>R</given-names> </name><name name-style="western"><surname>Patterson</surname><given-names>M</given-names> </name><name name-style="western"><surname>Lundmark</surname><given-names>V</given-names> </name><name name-style="western"><surname>Kiesler</surname><given-names>S</given-names> </name><name name-style="western"><surname>Mukophadhyay</surname><given-names>T</given-names> </name><name name-style="western"><surname>Scherlis</surname><given-names>W</given-names> </name></person-group><article-title>Internet paradox: a social technology that reduces social involvement and psychological well-being?</article-title><source>American Psychologist</source><year>1998</year><volume>53</volume><issue>9</issue><fpage>1017</fpage><lpage>1031</lpage><pub-id pub-id-type="doi">10.1037/0003-066X.53.9.1017</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Li</surname><given-names>L</given-names> </name><name name-style="western"><surname>Niu</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Griffiths</surname><given-names>MD</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>W</given-names> </name><name name-style="western"><surname>Chang</surname><given-names>C</given-names> </name><name name-style="western"><surname>Mei</surname><given-names>S</given-names> </name></person-group><article-title>A network perspective on the relationship between gaming disorder, depression, alexithymia, boredom, and loneliness among a sample of Chinese university students</article-title><source>Technol Soc</source><year>2021</year><month>11</month><volume>67</volume><fpage>101740</fpage><pub-id pub-id-type="doi">10.1016/j.techsoc.2021.101740</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Reer</surname><given-names>F</given-names> </name><name name-style="western"><surname>Festl</surname><given-names>R</given-names> </name><name name-style="western"><surname>Quandt</surname><given-names>T</given-names> </name></person-group><article-title>Investigating problematic social media and game use in a nationally representative sample of adolescents and younger adults</article-title><source>Behav Inf Technol</source><year>2021</year><month>06</month><day>11</day><volume>40</volume><issue>8</issue><fpage>776</fpage><lpage>789</lpage><pub-id pub-id-type="doi">10.1080/0144929X.2020.1724333</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lapierre</surname><given-names>MA</given-names> </name></person-group><article-title>Smartphones and loneliness in love: testing links between smartphone engagement, loneliness, and relational health</article-title><source>Psychology of Popular Media</source><year>2020</year><volume>9</volume><issue>2</issue><fpage>125</fpage><lpage>134</lpage><pub-id pub-id-type="doi">10.1037/ppm0000230</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Dalton</surname><given-names>F</given-names> </name><name name-style="western"><surname>Cassidy</surname><given-names>T</given-names> </name></person-group><article-title>Problematic Internet usage, personality, loneliness, and psychological well&#x2010;being in emerging adulthood</article-title><source>Anal Soc Iss &#x0026; Public Policy</source><year>2021</year><month>12</month><volume>21</volume><issue>1</issue><fpage>509</fpage><lpage>519</lpage><pub-id pub-id-type="doi">10.1111/asap.12224</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mozafar Saadati</surname><given-names>H</given-names> </name><name name-style="western"><surname>Mirzaei</surname><given-names>H</given-names> </name><name name-style="western"><surname>Okhovat</surname><given-names>B</given-names> </name><name name-style="western"><surname>Khodamoradi</surname><given-names>F</given-names> </name></person-group><article-title>Association between internet addiction and loneliness across the world: a meta-analysis and systematic review</article-title><source>SSM Popul Health</source><year>2021</year><month>12</month><volume>16</volume><fpage>100948</fpage><pub-id pub-id-type="doi">10.1016/j.ssmph.2021.100948</pub-id><pub-id pub-id-type="medline">34754896</pub-id></nlm-citation></ref><ref id="ref11"><label>11</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Moretta</surname><given-names>T</given-names> </name><name name-style="western"><surname>Buodo</surname><given-names>G</given-names> </name></person-group><article-title>Problematic internet use and loneliness: how complex is the relationship? A short literature review</article-title><source>Curr Addict Rep</source><year>2020</year><month>06</month><volume>7</volume><issue>2</issue><fpage>125</fpage><lpage>136</lpage><pub-id pub-id-type="doi">10.1007/s40429-020-00305-z</pub-id></nlm-citation></ref><ref id="ref12"><label>12</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Cai</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Mao</surname><given-names>P</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>D</given-names> </name><name name-style="western"><surname>He</surname><given-names>J</given-names> </name><name name-style="western"><surname>Fan</surname><given-names>X</given-names> </name></person-group><article-title>Associations between problematic internet use and mental health outcomes of students: a meta-analytic review</article-title><source>Adolesc Res Rev</source><year>2023</year><volume>8</volume><issue>1</issue><fpage>45</fpage><lpage>62</lpage><pub-id pub-id-type="doi">10.1007/s40894-022-00201-9</pub-id><pub-id pub-id-type="medline">36744121</pub-id></nlm-citation></ref><ref id="ref13"><label>13</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>O&#x2019;Day</surname><given-names>EB</given-names> </name><name name-style="western"><surname>Heimberg</surname><given-names>RG</given-names> </name></person-group><article-title>Social media use, social anxiety, and loneliness: a systematic review</article-title><source>Computers in Human Behavior Reports</source><year>2021</year><month>01</month><volume>3</volume><fpage>100070</fpage><pub-id pub-id-type="doi">10.1016/j.chbr.2021.100070</pub-id></nlm-citation></ref><ref id="ref14"><label>14</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Gao</surname><given-names>B</given-names> </name><name name-style="western"><surname>Cai</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Zhao</surname><given-names>C</given-names> </name><name name-style="western"><surname>Qian</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Zheng</surname><given-names>R</given-names> </name><name name-style="western"><surname>Liu</surname><given-names>C</given-names> </name></person-group><article-title>Longitudinal associations between loneliness and online game addiction among undergraduates: a moderated mediation model</article-title><source>Acta Psychol (Amst)</source><year>2024</year><month>03</month><volume>243</volume><fpage>104134</fpage><pub-id pub-id-type="doi">10.1016/j.actpsy.2024.104134</pub-id><pub-id pub-id-type="medline">38228073</pub-id></nlm-citation></ref><ref id="ref15"><label>15</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Rogier</surname><given-names>G</given-names> </name><name name-style="western"><surname>Zobel</surname><given-names>SB</given-names> </name><name name-style="western"><surname>Velotti</surname><given-names>P</given-names> </name></person-group><article-title>COVID-19, loneliness and technological addiction: longitudinal data</article-title><source>JGI</source><year>2021</year><issue>47</issue><pub-id pub-id-type="doi">10.4309/jgi.2021.47.4</pub-id></nlm-citation></ref><ref id="ref16"><label>16</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kim</surname><given-names>JH</given-names> </name></person-group><article-title>Longitudinal associations among psychological issues and problematic use of smartphones</article-title><source>J Media Psychol</source><year>2019</year><month>07</month><volume>31</volume><issue>3</issue><fpage>117</fpage><lpage>127</lpage><pub-id pub-id-type="doi">10.1027/1864-1105/a000234</pub-id></nlm-citation></ref><ref id="ref17"><label>17</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kardefelt-Winther</surname><given-names>D</given-names> </name></person-group><article-title>A conceptual and methodological critique of internet addiction research: towards a model of compensatory internet use</article-title><source>Comput Human Behav</source><year>2014</year><month>02</month><volume>31</volume><fpage>351</fpage><lpage>354</lpage><pub-id pub-id-type="doi">10.1016/j.chb.2013.10.059</pub-id></nlm-citation></ref><ref id="ref18"><label>18</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Karsay</surname><given-names>K</given-names> </name><name name-style="western"><surname>Schmuck</surname><given-names>D</given-names> </name><name name-style="western"><surname>Matthes</surname><given-names>J</given-names> </name><name name-style="western"><surname>Stevic</surname><given-names>A</given-names> </name></person-group><article-title>Longitudinal effects of excessive smartphone use on stress and loneliness: the moderating role of self-disclosure</article-title><source>Cyberpsychol Behav Soc Netw</source><year>2019</year><month>11</month><volume>22</volume><issue>11</issue><fpage>706</fpage><lpage>713</lpage><pub-id pub-id-type="doi">10.1089/cyber.2019.0255</pub-id><pub-id pub-id-type="medline">31697600</pub-id></nlm-citation></ref><ref id="ref19"><label>19</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Bryant</surname><given-names>J</given-names> </name><name name-style="western"><surname>Fondren</surname><given-names>W</given-names> </name></person-group><person-group person-group-type="editor"><name name-style="western"><surname>Nabi</surname><given-names>NL</given-names> </name><name name-style="western"><surname>MB</surname><given-names>O</given-names> </name></person-group><article-title>Displacement effects</article-title><source>Handbook of Media Processes and Effects</source><year>2009</year><publisher-name>Sage</publisher-name><fpage>505</fpage><lpage>516</lpage><pub-id pub-id-type="doi">10.4324/9780203877111</pub-id></nlm-citation></ref><ref id="ref20"><label>20</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Chan</surname><given-names>DKS</given-names> </name><name name-style="western"><surname>Cheng</surname><given-names>GHL</given-names> </name></person-group><article-title>A comparison of offline and online friendship qualities at different stages of relationship development</article-title><source>J Soc Pers Relat</source><year>2004</year><month>06</month><volume>21</volume><issue>3</issue><fpage>305</fpage><lpage>320</lpage><pub-id pub-id-type="doi">10.1177/0265407504042834</pub-id></nlm-citation></ref><ref id="ref21"><label>21</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lapierre</surname><given-names>MA</given-names> </name><name name-style="western"><surname>Zhao</surname><given-names>P</given-names> </name><name name-style="western"><surname>Custer</surname><given-names>BE</given-names> </name></person-group><article-title>Short-term longitudinal relationships between smartphone use/dependency and psychological well-being among late adolescents</article-title><source>J Adolesc Health</source><year>2019</year><month>11</month><volume>65</volume><issue>5</issue><fpage>607</fpage><lpage>612</lpage><pub-id pub-id-type="doi">10.1016/j.jadohealth.2019.06.001</pub-id><pub-id pub-id-type="medline">31477510</pub-id></nlm-citation></ref><ref id="ref22"><label>22</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Reed</surname><given-names>P</given-names> </name><name name-style="western"><surname>Davies</surname><given-names>A</given-names> </name><name name-style="western"><surname>Evans</surname><given-names>K</given-names> </name><name name-style="western"><surname>Osborne</surname><given-names>LA</given-names> </name></person-group><article-title>Longitudinal relationship between problematic internet use with loneliness during and after COVID-19 social restrictions: short title: Internet use and loneliness</article-title><source>Psychiatry Res</source><year>2023</year><month>05</month><volume>323</volume><fpage>115148</fpage><pub-id pub-id-type="doi">10.1016/j.psychres.2023.115148</pub-id><pub-id pub-id-type="medline">36905904</pub-id></nlm-citation></ref><ref id="ref23"><label>23</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Zhou</surname><given-names>W</given-names> </name><name name-style="western"><surname>Yan</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Yang</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Hussain</surname><given-names>Z</given-names> </name></person-group><article-title>Problematic social media use and mental health risks among first-year Chinese undergraduates: a three-wave longitudinal study</article-title><source>Front Psychiatry</source><year>2023</year><volume>14</volume><fpage>1237924</fpage><pub-id pub-id-type="doi">10.3389/fpsyt.2023.1237924</pub-id><pub-id pub-id-type="medline">37743982</pub-id></nlm-citation></ref><ref id="ref24"><label>24</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Zhang</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Li</surname><given-names>J</given-names> </name><name name-style="western"><surname>Zhang</surname><given-names>M</given-names> </name><name name-style="western"><surname>Ai</surname><given-names>B</given-names> </name><name name-style="western"><surname>Jia</surname><given-names>F</given-names> </name></person-group><article-title>Bidirectional associations between loneliness and problematic internet use: a meta-analytic review of longitudinal studies</article-title><source>Addict Behav</source><year>2024</year><month>03</month><volume>150</volume><fpage>107916</fpage><pub-id pub-id-type="doi">10.1016/j.addbeh.2023.107916</pub-id><pub-id pub-id-type="medline">37995611</pub-id></nlm-citation></ref><ref id="ref25"><label>25</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Fang</surname><given-names>X</given-names> </name><name name-style="western"><surname>Tian</surname><given-names>M</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>R</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>P</given-names> </name></person-group><article-title>Relationships between depression, loneliness and pathological internet use in adolescents: a cross-lagged analysis</article-title><source>Curr Psychol</source><year>2023</year><month>08</month><volume>42</volume><issue>24</issue><fpage>20696</fpage><lpage>20706</lpage><pub-id pub-id-type="doi">10.1007/s12144-022-03180-1</pub-id></nlm-citation></ref><ref id="ref26"><label>26</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Page</surname><given-names>MJ</given-names> </name><name name-style="western"><surname>McKenzie</surname><given-names>JE</given-names> </name><name name-style="western"><surname>Bossuyt</surname><given-names>PM</given-names> </name><etal/></person-group><article-title>The PRISMA 2020 statement: an updated guideline for reporting systematic reviews</article-title><source>BMJ</source><year>2021</year><month>03</month><day>29</day><volume>372</volume><fpage>n71</fpage><pub-id pub-id-type="doi">10.1136/bmj.n71</pub-id><pub-id pub-id-type="medline">33782057</pub-id></nlm-citation></ref><ref id="ref27"><label>27</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Borenstein</surname><given-names>M</given-names> </name><name name-style="western"><surname>Cooper</surname><given-names>H</given-names> </name><name name-style="western"><surname>Hedges</surname><given-names>L</given-names> </name><name name-style="western"><surname>Valentine</surname><given-names>J</given-names> </name></person-group><person-group person-group-type="editor"><name name-style="western"><surname>Borenstein</surname><given-names>M</given-names> </name><name name-style="western"><surname>Hedges</surname><given-names>LV</given-names> </name><name name-style="western"><surname>Higgins</surname><given-names>JPT</given-names> </name><name name-style="western"><surname>HR</surname><given-names>R</given-names> </name></person-group><article-title>Effect sizes for continuous data</article-title><source>The Handbook of Research Synthesis and Meta-Analysis: Russell Sage Foundation</source><year>2009</year><fpage>45</fpage><lpage>49</lpage></nlm-citation></ref><ref id="ref28"><label>28</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Cohen</surname><given-names>J</given-names> </name><name name-style="western"><surname>Cohen</surname><given-names>P</given-names> </name><name name-style="western"><surname>West</surname><given-names>SG</given-names> </name><name name-style="western"><surname>Aiken</surname><given-names>LS</given-names> </name></person-group><source>Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences</source><year>2013</year><edition>3</edition><pub-id pub-id-type="doi">10.4324/9780203774441</pub-id><pub-id pub-id-type="other">0203774442</pub-id></nlm-citation></ref><ref id="ref29"><label>29</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Moola</surname><given-names>S</given-names> </name><name name-style="western"><surname>Munn</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Tufanaru</surname><given-names>C</given-names> </name><name name-style="western"><surname>Aromataris</surname><given-names>E</given-names> </name><name name-style="western"><surname>Sears</surname><given-names>K</given-names> </name><name name-style="western"><surname>Sfetcu</surname><given-names>R</given-names> </name><etal/></person-group><article-title>Chapter 7: systematic reviews of etiology and risk. in: e, z m, editors. JBI manual for evidence synthesis</article-title><source>Aromataris</source><year>2020</year><publisher-name>JBI Manual for Evidence Synthesis: JBI</publisher-name><pub-id pub-id-type="doi">10.46658/JBIRM-17-06</pub-id></nlm-citation></ref><ref id="ref30"><label>30</label><nlm-citation citation-type="report"><person-group person-group-type="author"><collab>R Core Team</collab></person-group><article-title>R: a language and environment for statistical computing</article-title><year>2013</year><access-date>2025-07-31</access-date><publisher-name>R Foundation for Statistical Computing</publisher-name><comment><ext-link ext-link-type="uri" xlink:href="http://www.R-project.org/">http://www.R-project.org/</ext-link></comment></nlm-citation></ref><ref id="ref31"><label>31</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Botella</surname><given-names>J</given-names> </name><name name-style="western"><surname>S&#x00E1;nchez-Meca</surname><given-names>J</given-names> </name></person-group><article-title>Meta-analysis: confidence intervals and prediction intervals</article-title><source>An psicol</source><year>2024</year><volume>40</volume><issue>2</issue><fpage>344</fpage><lpage>354</lpage><pub-id pub-id-type="doi">10.6018/analesps.591831</pub-id></nlm-citation></ref><ref id="ref32"><label>32</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Higgins</surname><given-names>JPT</given-names> </name></person-group><article-title>Measuring inconsistency in meta-analyses</article-title><source>BMJ</source><year>2003</year><month>09</month><day>6</day><volume>327</volume><issue>7414</issue><fpage>557</fpage><lpage>560</lpage><pub-id pub-id-type="doi">10.1136/bmj.327.7414.557</pub-id></nlm-citation></ref><ref id="ref33"><label>33</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Borenstein</surname><given-names>M</given-names> </name></person-group><source>Common Mistakes in Meta-Analysis and How to Avoid Them</source><year>2019</year><publisher-name>Biostat Inc</publisher-name></nlm-citation></ref><ref id="ref34"><label>34</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hu</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Xiang</surname><given-names>Y</given-names> </name></person-group><article-title>Who Is the chief culprit, loneliness, or smartphone addiction? Evidence from longitudinal study and weekly diary method</article-title><source>Int J Ment Health Addiction</source><year>2024</year><month>02</month><volume>22</volume><issue>1</issue><fpage>599</fpage><lpage>614</lpage><pub-id pub-id-type="doi">10.1007/s11469-022-00892-0</pub-id></nlm-citation></ref><ref id="ref35"><label>35</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Finser&#x00E5;s</surname><given-names>TR</given-names> </name><name name-style="western"><surname>Pallesen</surname><given-names>S</given-names> </name><name name-style="western"><surname>Mentzoni</surname><given-names>RA</given-names> </name><name name-style="western"><surname>Krossbakken</surname><given-names>E</given-names> </name><name name-style="western"><surname>King</surname><given-names>DL</given-names> </name><name name-style="western"><surname>Molde</surname><given-names>H</given-names> </name></person-group><article-title>Evaluating an internet gaming disorder scale using Mokken Scaling Analysis</article-title><source>Front Psychol</source><year>2019</year><volume>10</volume><fpage>911</fpage><pub-id pub-id-type="doi">10.3389/fpsyg.2019.00911</pub-id><pub-id pub-id-type="medline">31080426</pub-id></nlm-citation></ref><ref id="ref36"><label>36</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Gao</surname><given-names>B</given-names> </name><name name-style="western"><surname>Xu</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Bai</surname><given-names>L</given-names> </name><name name-style="western"><surname>Luo</surname><given-names>G</given-names> </name><name name-style="western"><surname>Li</surname><given-names>W</given-names> </name></person-group><article-title>More grateful, less addicted! Understanding how gratitude affects online gaming addiction among Chinese college students: a three-wave multiple mediation model</article-title><source>BMC Psychol</source><year>2023</year><month>08</month><day>23</day><volume>11</volume><issue>1</issue><fpage>241</fpage><pub-id pub-id-type="doi">10.1186/s40359-023-01271-7</pub-id><pub-id pub-id-type="medline">37612743</pub-id></nlm-citation></ref><ref id="ref37"><label>37</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Jia</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Yang</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Yang</surname><given-names>L</given-names> </name></person-group><article-title>Chinese university students&#x2019; loneliness and generalized pathological internet use: a longitudinal cross-lagged analysis</article-title><source>soc behav pers</source><year>2018</year><month>05</month><day>1</day><volume>46</volume><issue>5</issue><fpage>861</fpage><lpage>870</lpage><pub-id pub-id-type="doi">10.2224/sbp.6807</pub-id></nlm-citation></ref><ref id="ref38"><label>38</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Krossbakken</surname><given-names>E</given-names> </name><name name-style="western"><surname>Pallesen</surname><given-names>S</given-names> </name><name name-style="western"><surname>Mentzoni</surname><given-names>RA</given-names> </name><etal/></person-group><article-title>A cross-lagged study of developmental trajectories of video game engagement, addiction, and mental health</article-title><source>Front Psychol</source><year>2018</year><volume>9</volume><fpage>2239</fpage><pub-id pub-id-type="doi">10.3389/fpsyg.2018.02239</pub-id><pub-id pub-id-type="medline">30519203</pub-id></nlm-citation></ref><ref id="ref39"><label>39</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lemmens</surname><given-names>JS</given-names> </name><name name-style="western"><surname>Valkenburg</surname><given-names>PM</given-names> </name><name name-style="western"><surname>Peter</surname><given-names>J</given-names> </name></person-group><article-title>Psychosocial causes and consequences of pathological gaming</article-title><source>Comput Human Behav</source><year>2011</year><month>01</month><volume>27</volume><issue>1</issue><fpage>144</fpage><lpage>152</lpage><pub-id pub-id-type="doi">10.1016/j.chb.2010.07.015</pub-id></nlm-citation></ref><ref id="ref40"><label>40</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mun</surname><given-names>IB</given-names> </name></person-group><article-title>A longitudinal study on the effects of parental anxiety on mobile game addiction in adolescents: the mediating role of adolescent anxiety and loneliness</article-title><source>Int J Ment Health Addiction</source><year>2024</year><month>02</month><volume>22</volume><issue>1</issue><fpage>560</fpage><lpage>577</lpage><pub-id pub-id-type="doi">10.1007/s11469-022-00890-2</pub-id></nlm-citation></ref><ref id="ref41"><label>41</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ok</surname><given-names>C</given-names> </name></person-group><article-title>Extraversion, loneliness, and problematic game use: a longitudinal study</article-title><source>Pers Individ Dif</source><year>2021</year><month>01</month><volume>168</volume><fpage>110290</fpage><pub-id pub-id-type="doi">10.1016/j.paid.2020.110290</pub-id></nlm-citation></ref><ref id="ref42"><label>42</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Olsen</surname><given-names>OK</given-names> </name><name name-style="western"><surname>Pallesen</surname><given-names>S</given-names> </name><name name-style="western"><surname>Myrseth</surname><given-names>H</given-names> </name></person-group><article-title>Gaming in the military: a longitudinal study of changes in gaming behavior among conscripts during military service and associated risk factors</article-title><source>Front Psychiatry</source><year>2021</year><volume>12</volume><fpage>591038</fpage><pub-id pub-id-type="doi">10.3389/fpsyt.2021.591038</pub-id><pub-id pub-id-type="medline">34305660</pub-id></nlm-citation></ref><ref id="ref43"><label>43</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Shi</surname><given-names>X</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>A</given-names> </name><name name-style="western"><surname>Zhu</surname><given-names>Y</given-names> </name></person-group><article-title>Longitudinal associations among smartphone addiction, loneliness, and depressive symptoms in college students: disentangling between- and within-person associations</article-title><source>Addict Behav</source><year>2023</year><month>07</month><volume>142</volume><fpage>107676</fpage><pub-id pub-id-type="doi">10.1016/j.addbeh.2023.107676</pub-id><pub-id pub-id-type="medline">36878182</pub-id></nlm-citation></ref><ref id="ref44"><label>44</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Tian</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Guo</surname><given-names>ZX</given-names> </name><name name-style="western"><surname>Shi</surname><given-names>JR</given-names> </name><etal/></person-group><article-title>Bidirectional mediating role of loneliness in the association between shyness and generalized pathological internet use in Chinese university students: a longitudinal cross-lagged analysis</article-title><source>J Psychol</source><year>2018</year><volume>152</volume><issue>8</issue><fpage>529</fpage><lpage>547</lpage><pub-id pub-id-type="doi">10.1080/00223980.2018.1468309</pub-id><pub-id pub-id-type="medline">30376647</pub-id></nlm-citation></ref><ref id="ref45"><label>45</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Tian</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Qin</surname><given-names>N</given-names> </name><name name-style="western"><surname>Cao</surname><given-names>S</given-names> </name><name name-style="western"><surname>Gao</surname><given-names>F</given-names> </name></person-group><article-title>Reciprocal associations between shyness, self-esteem, loneliness, depression and Internet addiction in Chinese adolescents</article-title><source>Addict Res Theory</source><year>2021</year><month>03</month><day>4</day><volume>29</volume><issue>2</issue><fpage>98</fpage><lpage>110</lpage><pub-id pub-id-type="doi">10.1080/16066359.2020.1755657</pub-id></nlm-citation></ref><ref id="ref46"><label>46</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>T&#x00F3;th-Kir&#x00E1;ly</surname><given-names>I</given-names> </name><name name-style="western"><surname>Morin</surname><given-names>AJS</given-names> </name><name name-style="western"><surname>Hietaj&#x00E4;rvi</surname><given-names>L</given-names> </name><name name-style="western"><surname>Salmela-Aro</surname><given-names>K</given-names> </name></person-group><article-title>Longitudinal trajectories, social and individual antecedents, and outcomes of problematic internet use among late adolescents</article-title><source>Child Dev</source><year>2021</year><month>07</month><volume>92</volume><issue>4</issue><fpage>e653</fpage><lpage>e673</lpage><pub-id pub-id-type="doi">10.1111/cdev.13525</pub-id><pub-id pub-id-type="medline">33511643</pub-id></nlm-citation></ref><ref id="ref47"><label>47</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wang</surname><given-names>A</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Zhu</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Shi</surname><given-names>X</given-names> </name></person-group><article-title>The prevalence and psychosocial factors of problematic smartphone use among Chinese college students: a three-wave longitudinal study</article-title><source>Front Psychol</source><year>2022</year><volume>13</volume><fpage>877277</fpage><pub-id pub-id-type="doi">10.3389/fpsyg.2022.877277</pub-id><pub-id pub-id-type="medline">35450331</pub-id></nlm-citation></ref><ref id="ref48"><label>48</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wang</surname><given-names>P</given-names> </name><name name-style="western"><surname>Wang</surname><given-names>X</given-names> </name><name name-style="western"><surname>Gao</surname><given-names>T</given-names> </name><etal/></person-group><article-title>Problematic internet use in early adolescents: gender and loneliness differences in a latent growth model</article-title><source>Psychol Res Behav Manag</source><year>2023</year><volume>16</volume><fpage>3583</fpage><lpage>3596</lpage><pub-id pub-id-type="doi">10.2147/PRBM.S428422</pub-id><pub-id pub-id-type="medline">37693330</pub-id></nlm-citation></ref><ref id="ref49"><label>49</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wu</surname><given-names>P</given-names> </name><name name-style="western"><surname>Feng</surname><given-names>R</given-names> </name><name name-style="western"><surname>Zhang</surname><given-names>J</given-names> </name></person-group><article-title>The relationship between loneliness and problematic social media usage in Chinese university students: a longitudinal study</article-title><source>BMC Psychol</source><year>2024</year><month>01</month><day>4</day><volume>12</volume><issue>1</issue><fpage>13</fpage><pub-id pub-id-type="doi">10.1186/s40359-023-01498-4</pub-id><pub-id pub-id-type="medline">38178215</pub-id></nlm-citation></ref><ref id="ref50"><label>50</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Yao</surname><given-names>MZ</given-names> </name><name name-style="western"><surname>Zhong</surname><given-names>ZJ</given-names> </name></person-group><article-title>Loneliness, social contacts and Internet addiction: a cross-lagged panel study</article-title><source>Comput Human Behav</source><year>2014</year><month>01</month><volume>30</volume><fpage>164</fpage><lpage>170</lpage><pub-id pub-id-type="doi">10.1016/j.chb.2013.08.007</pub-id></nlm-citation></ref><ref id="ref51"><label>51</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Yang</surname><given-names>C</given-names> </name><name name-style="western"><surname>Carter</surname><given-names>MDK</given-names> </name><name name-style="western"><surname>Webb</surname><given-names>JJ</given-names> </name><name name-style="western"><surname>Holden</surname><given-names>SM</given-names> </name></person-group><article-title>Developmentally salient psychosocial characteristics, rumination, and compulsive social media use during the transition to college</article-title><source>Addict Res Theory</source><year>2020</year><month>09</month><day>2</day><volume>28</volume><issue>5</issue><fpage>433</fpage><lpage>442</lpage><pub-id pub-id-type="doi">10.1080/16066359.2019.1682137</pub-id></nlm-citation></ref><ref id="ref52"><label>52</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Casale</surname><given-names>S</given-names> </name><name name-style="western"><surname>Akbari</surname><given-names>M</given-names> </name><name name-style="western"><surname>Bocci Benucci</surname><given-names>S</given-names> </name><name name-style="western"><surname>Seydavi</surname><given-names>M</given-names> </name><name name-style="western"><surname>Fioravanti</surname><given-names>G</given-names> </name></person-group><article-title>Interpersonally-based fears and problematic social networking site use: the moderating role of online social support</article-title><source>Int J Ment Health Addiction</source><year>2024</year><month>06</month><volume>22</volume><issue>3</issue><fpage>995</fpage><lpage>1007</lpage><pub-id pub-id-type="doi">10.1007/s11469-022-00908-9</pub-id></nlm-citation></ref><ref id="ref53"><label>53</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kraut</surname><given-names>R</given-names> </name><name name-style="western"><surname>Kiesler</surname><given-names>S</given-names> </name><name name-style="western"><surname>Boneva</surname><given-names>B</given-names> </name><name name-style="western"><surname>Cummings</surname><given-names>J</given-names> </name><name name-style="western"><surname>Helgeson</surname><given-names>V</given-names> </name><name name-style="western"><surname>Crawford</surname><given-names>A</given-names> </name></person-group><article-title>Internet paradox revisited</article-title><source>Journal of Social Issues</source><year>2002</year><month>01</month><volume>58</volume><issue>1</issue><fpage>49</fpage><lpage>74</lpage><comment><ext-link ext-link-type="uri" xlink:href="https://spssi.onlinelibrary.wiley.com/toc/15404560/58/1">https://spssi.onlinelibrary.wiley.com/toc/15404560/58/1</ext-link></comment><pub-id pub-id-type="doi">10.1111/1540-4560.00248</pub-id></nlm-citation></ref><ref id="ref54"><label>54</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Scott</surname><given-names>RA</given-names> </name><name name-style="western"><surname>Stuart</surname><given-names>J</given-names> </name><name name-style="western"><surname>Barber</surname><given-names>BL</given-names> </name></person-group><article-title>Contemporary friendships and social vulnerability among youth: understanding the role of online and offline contexts of interaction in friendship quality</article-title><source>J Soc Pers Relat</source><year>2021</year><month>12</month><volume>38</volume><issue>12</issue><fpage>3451</fpage><lpage>3471</lpage><pub-id pub-id-type="doi">10.1177/02654075211029384</pub-id></nlm-citation></ref><ref id="ref55"><label>55</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mittmann</surname><given-names>G</given-names> </name><name name-style="western"><surname>Woodcock</surname><given-names>K</given-names> </name><name name-style="western"><surname>D&#x00F6;rfler</surname><given-names>S</given-names> </name><name name-style="western"><surname>Krammer</surname><given-names>I</given-names> </name><name name-style="western"><surname>Pollak</surname><given-names>I</given-names> </name><name name-style="western"><surname>Schrank</surname><given-names>B</given-names> </name></person-group><article-title>&#x201C;TikTok Is My Life and Snapchat Is My Ventricle&#x201D;: a mixed-methods study on the role of online communication tools for friendships in early adolescents</article-title><source>J Early Adolesc</source><year>2022</year><month>02</month><volume>42</volume><issue>2</issue><fpage>172</fpage><lpage>203</lpage><pub-id pub-id-type="doi">10.1177/02724316211020368</pub-id></nlm-citation></ref><ref id="ref56"><label>56</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Skues</surname><given-names>J</given-names> </name><name name-style="western"><surname>Williams</surname><given-names>BJ</given-names> </name><name name-style="western"><surname>Wise</surname><given-names>L</given-names> </name></person-group><article-title>Personality traits, boredom, and loneliness as predictors of facebook use in on-campus and online university students</article-title><source>International Journal of Cyber Behavior, Psychology and Learning</source><year>2017</year><volume>7</volume><issue>2</issue><fpage>36</fpage><lpage>48</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/IJCBPL.20170401">http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/IJCBPL.20170401</ext-link></comment><pub-id pub-id-type="doi">10.4018/IJCBPL.2017040104</pub-id></nlm-citation></ref><ref id="ref57"><label>57</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Song</surname><given-names>H</given-names> </name><name name-style="western"><surname>Zmyslinski-Seelig</surname><given-names>A</given-names> </name><name name-style="western"><surname>Kim</surname><given-names>J</given-names> </name><etal/></person-group><article-title>Does Facebook make you lonely?: a meta analysis</article-title><source>Comput Human Behav</source><year>2014</year><month>07</month><volume>36</volume><fpage>446</fpage><lpage>452</lpage><pub-id pub-id-type="doi">10.1016/j.chb.2014.04.011</pub-id></nlm-citation></ref><ref id="ref58"><label>58</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Yu</surname><given-names>K</given-names> </name><name name-style="western"><surname>Wu</surname><given-names>S</given-names> </name><name name-style="western"><surname>Chi</surname><given-names>I</given-names> </name></person-group><article-title>Internet use and loneliness of older adults over time: the mediating effect of social contact</article-title><source>J Gerontol B Psychol Sci Soc Sci</source><year>2021</year><month>02</month><day>17</day><volume>76</volume><issue>3</issue><fpage>541</fpage><lpage>550</lpage><pub-id pub-id-type="doi">10.1093/geronb/gbaa004</pub-id><pub-id pub-id-type="medline">31942629</pub-id></nlm-citation></ref><ref id="ref59"><label>59</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Szabo</surname><given-names>A</given-names> </name><name name-style="western"><surname>Allen</surname><given-names>J</given-names> </name><name name-style="western"><surname>Stephens</surname><given-names>C</given-names> </name><name name-style="western"><surname>Alpass</surname><given-names>F</given-names> </name></person-group><article-title>Longitudinal analysis of the relationship between purposes of internet use and well-being among older adults</article-title><source>Gerontologist</source><year>2019</year><month>01</month><day>9</day><volume>59</volume><issue>1</issue><fpage>58</fpage><lpage>68</lpage><pub-id pub-id-type="doi">10.1093/geront/gny036</pub-id><pub-id pub-id-type="medline">29688332</pub-id></nlm-citation></ref><ref id="ref60"><label>60</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Sterne</surname><given-names>JAC</given-names> </name><name name-style="western"><surname>Sutton</surname><given-names>AJ</given-names> </name><name name-style="western"><surname>Ioannidis</surname><given-names>JPA</given-names> </name><etal/></person-group><article-title>Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials</article-title><source>BMJ</source><year>2011</year><month>07</month><day>22</day><volume>343</volume><fpage>d4002</fpage><pub-id pub-id-type="doi">10.1136/bmj.d4002</pub-id><pub-id pub-id-type="medline">21784880</pub-id></nlm-citation></ref></ref-list><app-group><supplementary-material id="app1"><label>Checklist 1</label><p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 abstract checklist.</p><media xlink:href="jmir_v27i1e60410_app1.docx" xlink:title="DOCX File, 26 KB"/></supplementary-material></app-group></back></article>