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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v27i1e53741</article-id>
      <article-id pub-id-type="pmid">39913918</article-id>
      <article-id pub-id-type="doi">10.2196/53741</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Mapping and Summarizing the Research on AI Systems for Automating Medical History Taking and Triage: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Yao</surname>
            <given-names>Li-Hung</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Harada</surname>
            <given-names>Yukinori</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Nilsson</surname>
            <given-names>Evalill</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Siira</surname>
            <given-names>Elin</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>School of Health and Welfare</institution>
            <institution>Halmstad University</institution>
            <addr-line>Box 823</addr-line>
            <addr-line>Halmstad, 301 18</addr-line>
            <country>Sweden</country>
            <phone>46 70 692 46 13</phone>
            <email>elin.siira@hh.se</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-3097-9147</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Johansson</surname>
            <given-names>Hanna</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0006-8895-4547</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Nygren</surname>
            <given-names>Jens</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-3576-2393</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>School of Health and Welfare</institution>
        <institution>Halmstad University</institution>
        <addr-line>Halmstad</addr-line>
        <country>Sweden</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Elin Siira <email>elin.siira@hh.se</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>6</day>
        <month>2</month>
        <year>2025</year>
      </pub-date>
      <volume>27</volume>
      <elocation-id>e53741</elocation-id>
      <history>
        <date date-type="received">
          <day>17</day>
          <month>10</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>10</day>
          <month>2</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd">
          <day>15</day>
          <month>4</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>27</day>
          <month>12</month>
          <year>2024</year>
        </date>
      </history>
      <copyright-statement>©Elin Siira, Hanna Johansson, Jens Nygren. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 06.02.2025.</copyright-statement>
      <copyright-year>2025</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2025/1/e53741" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The integration of artificial intelligence (AI) systems for automating medical history taking and triage can significantly enhance patient flow in health care systems. Despite the promising performance of numerous AI studies, only a limited number of these systems have been successfully integrated into routine health care practice. To elucidate how AI systems can create value in this context, it is crucial to identify the current state of knowledge, including the readiness of these systems, the facilitators of and barriers to their implementation, and the perspectives of various stakeholders involved in their development and deployment.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aims to map and summarize empirical research on AI systems designed for automating medical history taking and triage in health care settings.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>The study was conducted following the framework proposed by Arksey and O’Malley and adhered to the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines. A comprehensive search of 5 databases—PubMed, CINAHL, PsycINFO, Scopus, and Web of Science—was performed. A detailed protocol was established before the review to ensure methodological rigor.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>A total of 1248 research publications were identified and screened. Of these, 86 (6.89%) met the eligibility criteria. Notably, most (n=63, 73%) studies were published between 2020 and 2022, with a significant concentration on emergency care (n=32, 37%). Other clinical contexts included radiology (n=12, 14%) and primary care (n=6, 7%). Many (n=15, 17%) studies did not specify a clinical context. Most (n=31, 36%) studies used retrospective designs, while others (n=34, 40%) did not specify their methodologies. The predominant type of AI system identified was the hybrid model (n=68, 79%), with forecasting (n=40, 47%) and recognition (n=36, 42%) being the most common tasks performed. While most (n=70, 81%) studies included patient populations, only 1 (1%) study investigated patients’ views on AI-based medical history taking and triage, and 2 (2%) studies considered health care professionals’ perspectives. Furthermore, only 6 (7%) studies validated or demonstrated AI systems in relevant clinical settings through real-time model testing, workflow implementation, clinical outcome evaluation, or integration into practice. Most (n=76, 88%) studies were concerned with the prototyping, development, or validation of AI systems. In total, 4 (5%) studies were reviews of several empirical studies conducted in different clinical settings. The facilitators and barriers to AI system implementation were categorized into 4 themes: technical aspects, contextual and cultural considerations, end-user engagement, and evaluation processes.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>This review highlights current trends, stakeholder perspectives, stages of innovation development, and key influencing factors related to implementing AI systems in health care. The identified literature gaps regarding stakeholder perspectives and the limited research on AI systems for automating medical history taking and triage indicate significant opportunities for further investigation and development in this evolving field.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>scoping review</kwd>
        <kwd>artificial intelligence</kwd>
        <kwd>AI</kwd>
        <kwd>medical history taking</kwd>
        <kwd>triage</kwd>
        <kwd>health care</kwd>
        <kwd>automation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>In health care, efficient management of the flow of patients through the health care system is important to ensure that care is accessible and appropriate, given the needs of patients [<xref ref-type="bibr" rid="ref1">1</xref>]. With the introduction of artificial intelligence (AI) systems, there has been growing interest in using these technologies to improve patient flow [<xref ref-type="bibr" rid="ref2">2</xref>]. Research in this area remains in its early stages, constituting a disjointed field [<xref ref-type="bibr" rid="ref3">3</xref>]. In addition, AI systems hold great promise to make patient flows more efficient at the admission of patients by improving triage [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>].</p>
        <p>Traditionally, triage involves a health care professional taking the patient’s medical history to systematically decide the optimal prioritization and assess the appropriate treatment for the patient. There are different types of triage, each with its distinctive elements, such as inpatient triage, emergency department triage, incident triage, military triage, and mass casualty triage, all of which possess the aforementioned characteristics [<xref ref-type="bibr" rid="ref6">6</xref>]. AI systems could potentially increase the efficiency of triage processes by replacing health care professionals in taking the patient’s medical history and directing patients to the most appropriate treatment. This could effectively reduce health care professionals’ workload and allow for a more optimal allocation of their time [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. Despite the high hopes and AI systems showing good performance in studies, only a small number have been implemented in operational health care systems [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>].</p>
        <p>To fully understand how AI systems for automating medical history taking and triage could be used to create value in the health care context, it is important to understand the entire development and implementation process, including data collection, algorithm development, model validation, and real-world implementation [<xref ref-type="bibr" rid="ref9">9</xref>]. Each of these steps presents unique challenges and considerations that must be carefully addressed to ensure successful integration into health care. It is essential to determine at which stage of the innovation development process the AI systems are halted or hindered before they are integrated into health care practices [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Many technical and nontechnical factors affect the implementation process. Technical challenges, such as data quality and interoperability, algorithm accuracy, and system reliability, must be carefully evaluated and addressed [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. In addition, ethical considerations, regulatory frameworks, organizational barriers, and patient acceptance play critical roles in the implementation and use of these technologies [<xref ref-type="bibr" rid="ref10">10</xref>]. By studying these factors, we can identify the barriers that hinder the effective implementation of AI systems and facilitate strategies to overcome them.</p>
        <p>However, it is equally important to recognize that the successful implementation of AI systems in health care extends beyond the technical and regulatory aspects. The perspectives of a wide range of stakeholders must be considered as they can offer valuable insights and contribute to the overall effectiveness and acceptance of these systems [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. Stakeholders include health care providers, patients, decision makers, regulatory bodies, administrators, and other context-based relevant actors. Each stakeholder group brings unique perspectives, priorities, and concerns, which must be integrated into the development and deployment of AI systems for medical history taking and triage [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. By incorporating such diverse perspectives, we can ensure that these technologies align with the needs, values, and expectations of the stakeholders they seek to serve.</p>
        <p>In light of these considerations, it is crucial to conduct a scoping review to map and summarize empirical research on AI systems for automating medical history taking and triage. By systematically reviewing the literature, we can identify the current state of knowledge across various stages of the innovation development process, gain insights into the hindering and facilitating factors affecting the implementation and use of AI systems, and consider the perspectives of different stakeholders. Such a comprehensive review will not only help identify gaps in knowledge but also guide future research efforts and inform evidence-based practice for integrating AI systems for automating medical history taking and triage in health care settings.</p>
      </sec>
      <sec>
        <title>Aim and Research Questions</title>
        <p>The aim of the scoping review was to map and summarize empirical research on AI systems for automating medical history taking and triage. The following research questions (RQs) guided this review:</p>
        <list list-type="order">
          <list-item>
            <p>What are the characteristics of research publications on AI systems for automated medical history taking and triage in health care?</p>
          </list-item>
          <list-item>
            <p>Whose perspective (researcher, health care professional, or patient) of the AI systems is described?</p>
          </list-item>
          <list-item>
            <p>At which stage of the innovation development process are the AI systems studied?</p>
          </list-item>
          <list-item>
            <p>What facilitating factors and barriers are considered in relation to the introduction of the AI systems?</p>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>The scoping review was designed according to the framework of Arksey and O’Malley [<xref ref-type="bibr" rid="ref14">14</xref>], which has been widely used to explore, summarize, and draw conclusions about the overall state of research on new technology and health care (refer to the studies by Sharma et al [<xref ref-type="bibr" rid="ref15">15</xref>], Gama et al [<xref ref-type="bibr" rid="ref16">16</xref>], and Wikström et al [<xref ref-type="bibr" rid="ref17">17</xref>]). The characteristics of included research publications (RQ1) and whose perspective is described in the publications (RQ2) are questions commonly addressed in scoping reviews. To investigate at which stages of the innovation development process the AI systems in the research publications were studied (RQ3), we adopted the Technology Readiness Level (TRL) scale for clinical readiness by Fleuren et al [<xref ref-type="bibr" rid="ref7">7</xref>]. The scale is based on the original TRL scale developed by the National Aeronautics and Space Administration to evaluate technological maturity. It measures the clinical applicability of AI (ie, machine learning) systems on a scale of 1 to 9 (1 being the least mature and 9 being the most mature) [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. To identify and report patterns in facilitating factors and barriers to the introduction of AI systems (RQ4), we used techniques from thematic analysis (ie, we coded the data and generated themes) [<xref ref-type="bibr" rid="ref19">19</xref>]. The scoping review was reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines [<xref ref-type="bibr" rid="ref20">20</xref>] (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>), and a scoping review protocol was established before conducting the review.</p>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>To cover any literature relevant to the scope of the review, we used 4 key terms: <italic>health care</italic>, <italic>AI systems</italic>, <italic>medical history-taking</italic>, and <italic>triage</italic> (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>). To systematically capture literature related to the key terms and synonyms, they were searched using both index terms (ie, subject headings) and free text, as outlined in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. To generate an extensive coverage of relevant studies, as recommended in scoping reviews [<xref ref-type="bibr" rid="ref14">14</xref>], 5 major databases for health care–related research were searched: PubMed, CINAHL, PsycINFO, Scopus, and Web of Science Core Collection. The search was conducted in October 2022. All the databases were searched for studies published between January 2000 and September 2022. The search strings were first piloted in one of the databases (PubMed) and then further developed with the support of a research librarian before systematically searching all 5 databases. <xref ref-type="boxed-text" rid="box2">Textbox 2</xref> provides an illustration of one of the search strings.</p>
        <boxed-text id="box1" position="float">
          <title>Key terms used in search and their definitions.</title>
          <list list-type="bullet">
            <list-item>
              <p>Healthcare: “...all the organizations, institutions and resources that are devoted to producing health actions” [<xref ref-type="bibr" rid="ref21">21</xref>]</p>
            </list-item>
            <list-item>
              <p>Artificial intelligence (AI) systems: “...a machine-based system that can, for a given set of human-defined objectives, make predictions, recommendations, or decisions influencing real or virtual environments. AI systems are designed to operate with varying levels of autonomy.” [<xref ref-type="bibr" rid="ref22">22</xref>]</p>
            </list-item>
            <list-item>
              <p>Medical history-taking: The process of acquiring information from a patient on medical conditions and past treatment [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]</p>
            </list-item>
            <list-item>
              <p>Triage: The process upon which the optimal prioritization and assessment of the appropriate next step for the patient can be decided [<xref ref-type="bibr" rid="ref6">6</xref>]</p>
            </list-item>
          </list>
        </boxed-text>
        <boxed-text id="box2" position="float">
          <title>Search string used for the PubMed database (publications were filtered for publication date from January 1, 2000, to September 30, 2022).</title>
          <p>((“neural networks, computer”[MeSH Terms:noexp] OR “artificial intelligence”[MeSH Terms:noexp] OR “deep learning”[MeSH Terms] OR “supervised machine learning”[MeSH Terms] OR “artificial intelligence”[Title/Abstract] OR “deep learning”[Title/Abstract] OR “supervised machine learning”[Title/Abstract]) AND (“delivery of health care”[MeSH Terms] OR “health care”[Title/Abstract] OR “healthcare”[Title/Abstract] OR “medical”[Title/Abstract] OR “clinical”[Title/Abstract])) AND (“Medical History Taking”[MeSH Terms] OR “anamnes*”[All Fields] OR “Triage”[MeSH Terms])</p>
        </boxed-text>
      </sec>
      <sec>
        <title>Eligibility Criteria</title>
        <p>The eligibility criteria were set to identify research publications that presented empirical studies or systematically conducted reviews of empirical studies that focused on AI systems for automating medical history taking and triage in health care. A retrieved study was eligible for inclusion if it (1) contained a title and abstract; (2) was written in English; (3) was published between January 1, 2000, and September 30, 2022; (4) was peer reviewed; (5) analyzed empirical data or systematically reviewed empirical data; and focused on (6) health care, (7) AI, and (8) medical history taking or triage (<xref ref-type="boxed-text" rid="box3">Textbox 3</xref>). Before using the eligibility criteria for study selection in all databases, we piloted the criteria for the studies retrieved from one of the databases (PubMed). The criteria were not altered after piloting.</p>
        <boxed-text id="box3" position="float">
          <title>Eligibility criteria.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <p>Contained title and abstract: Yes</p>
          <p>English language: Yes</p>
          <p>Publication date: January 1, 2000, to September 30, 2022</p>
          <p>Peer reviewed: Yes</p>
          <p>Empirical study: Analyzed empirical data or systematically reviewed articles with empirical data</p>
          <p>Focused on health care: Yes</p>
          <p>Focused on artificial intelligence: Yes</p>
          <p>Focused on medical history taking or triage: Yes</p>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <p>Contained title and abstract: No</p>
          <p>English language: No</p>
          <p>Publication date: Before December 31, 1999</p>
          <p>Peer reviewed: No</p>
          <p>Empirical study: Analyzed based on theoretical or hypothetical reasoning</p>
          <p>Focused on health care: No</p>
          <p>Focused on artificial intelligence: No</p>
          <p>Focused on medical history taking or triage: No</p>
        </boxed-text>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p>First, studies identified through the search strategy were imported into Endnote software (version 20; Clarivate) and exported to the Rayyan web application (Rayyan Systems, Inc) [<xref ref-type="bibr" rid="ref25">25</xref>] for controlled removal of duplicates. After the removal of duplicates, 2 of the authors (ES and HJ) independently screened the retrieved titles and abstracts for checking their eligibility for inclusion. When screening studies for inclusion, the authors checked the retrieved studies for inclusion according to the inclusion criteria in chronological order, that is, if criterion 1 was met, the authors checked if the retrieved study met inclusion criterion 2, and so on. Conference proceedings were excluded because they are often preliminary and based on limited analyses [<xref ref-type="bibr" rid="ref26">26</xref>]. Editorials, commentaries, viewpoints, discussion and opinion papers, and book chapters were excluded because they often do not undergo a rigorous and impartial peer-review process. Narrative and integrative reviews were excluded because they did not systematically analyze or review empirical data. Any disagreements during the screening of titles and abstracts were discussed with a third author (JN) until a consensus was reached. Full texts of the studies that met the inclusion criteria after screening titles and abstracts were assessed for eligibility. ES and HJ independently screened the full texts of the studies. Disagreements concerning the full-text screening were discussed among all the authors until a consensus was reached.</p>
      </sec>
      <sec>
        <title>Data Extraction</title>
        <p>A data extraction template was developed by one of the authors (ES) based on the RQs. The template was piloted with 5 studies before extracting the data from all included research publications. The template was not altered after piloting. To extract data relevant to the RQs, the template contained columns for information on the characteristics of the research publications (RQ1; authors, publication year, country, clinical setting, sample population, study aim, study design, type of AI system, and main task performed by AI system), the perspective described in the research publications (RQ2; ie, the researchers’, health care professionals’, or patients’ perspectives), the TRLs (1-9) of the AI systems in the research (RQ3), and facilitators and barriers to the introduction of the AI systems (RQ4). To identify the type of AI system and the main task performed by the AI system (RQ1), we adopted the operational terms presented in the Organisation for Economic Co-operation and Development Framework for the Classification of AI systems [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
        <p>We extracted data in relation to RQs 1 to 3 from all included studies, whereas data in relation to RQ4 were extracted only from the studies deemed to have TRLs equal to 6 or higher (ie, they reported a demonstration of an AI system in a real health care environment) and for literature reviews. In total, 2 (3%) of the 77 studies with TRLs ≥6 [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>] and 2 (33%) of the 6 literature reviews did not report the introduction of AI systems in real health care environments [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>]. Consequently, data from these studies did not address RQ4.</p>
        <p>Data on the characteristics of the research publications (RQ1) were extracted from the entire article; data on the perspective described in the research publications (RQ2) and the TRLs (RQ3) were extracted from the methods, results, and discussion sections of the articles. Finally, data on facilitators and barriers to the introduction of the AI systems (RQ4) were extracted from the results, discussion, and conclusions sections of the research publications.</p>
      </sec>
      <sec>
        <title>Data Analysis</title>
        <p>Following the framework proposed by Arksey and O’Malley [<xref ref-type="bibr" rid="ref14">14</xref>], we began the analysis with a basic numerical analysis of the extracted data and produced tables to report the distribution of the characteristics of the studies (RQ1), the perspective described in the studies (RQ2), and their TRLs (RQ3). Thereafter, to provide a narrative account of the facilitating factors and barriers to the introduction of the AI systems (RQ4), we coded and organized the extracted data thematically [<xref ref-type="bibr" rid="ref19">19</xref>] This involved an inductive iterative process in which we coded the extracted text on the facilitating factors and barriers and collated the codes into potential themes, which we then revised and refined. ES and HJ independently coded the data, compiled all the codes, and developed the final themes. The thematic analysis was finalized through a group discussion among all 3 authors.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Overview</title>
        <p>A total of 2008 records were retrieved from the electronic databases. After removing duplicates (n=760, 37.85%), 1248 records remained and were included in the screening. Of these, 133 (10.66%) records were assessed for eligibility in full text, and 86 (64.7%) were deemed eligible for inclusion. The PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) flow diagram gives the details on the identification and screening of studies (<xref rid="figure1" ref-type="fig">Figure 1</xref>) [<xref ref-type="bibr" rid="ref32">32</xref>].</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. AI: artificial intelligence.</p>
          </caption>
          <graphic xlink:href="jmir_v27i1e53741_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>RQ1: Characteristics of the Research Publications</title>
        <p>The included studies were published between 2000 and 2022, but most (63/86, 73%) of the studies were published between 2020 and 2022. The remaining studies (16/86, 19%) were published predominantly between 2018 and 2019. Only a small number of studies (7/86, 8%) were published between 2000 and 2017. Most of the studies were from Asia (26/86, 30%), particularly China (8/86, 9%); North America (25/86, 29%), predominantly the United States (23/86, 27%); and Europe (22/86, 26%), primarily the United Kingdom (9/86, 10%). A small number of studies (13/86, 15%) were from Africa (1/86, 1%), Oceania (5/86, 6%), and South America (4/86, 5%) or did not specify the country of origin (3/86, 3%). The most common clinical contexts in focus in the included studies were emergency care (32/86, 37%), followed by radiology (12/86, 14%) and primary care (6/86, 7%). In addition, a large number of studies (15/86, 17%) did not specify the clinical context in focus. The sample population in most studies consisted of patients (70/86, 81%), which included datasets of different types of patient records. In the remaining studies, the sample population was health care professionals (9/86, 10%), citizens (2/86, 2%), or unspecified (5/86, 6%). In these studies, the sample size was small, and there was a higher degree of involvement of the participants in the study. Regarding study design, a large number of studies were retrospective studies (31/86, 36%) or did not specify any specific design (29/86, 34%). Other study designs were, for example, prospective studies (7/86, 8%), different types of pilot studies (4/86, 5%), or reviews (4/86, 5%). The most common type of AI system was hybrid models (68/86, 79%), that is, they combined statistical and symbolic approaches. Most (40/86, 47%) of the AI systems studied were used for forecasting, that is, they predicted future outcomes based on past and present behavior or recognition (36/86, 42%), which involved identifying and categorizing data into specific classifications or performing image segmentation and object recognition. Definitions of the types of AI systems and their main tasks used in this review can be found in the Organisation for Economic Co-operation and Development Framework for the Classification of AI systems [<xref ref-type="bibr" rid="ref27">27</xref>]. <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> provides an overview of the characteristics of all the 86 included studies [<xref ref-type="bibr" rid="ref28">28</xref>-<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref114">114</xref>].</p>
      </sec>
      <sec>
        <title>RQ2: Perspectives Described in the Publications (Among Researchers, Health Care Professionals, or Patients)</title>
        <p>Although the sample population in a large number of the included studies consisted of patients, these studies did not portray their perspectives. In most (83/86, 97%) of the included studies, researchers’ perspectives were portrayed (ie, researchers’ description and interpretation of the AI system and the results of the particular study. Only 1 (1%) study reflected the patients’ perspectives [<xref ref-type="bibr" rid="ref87">87</xref>]. It described patient ratings of the usability and interface of an AI system for medical history taking in an emergency department. The same study also portrayed physicians’ and 10 nurses’ ratings for the same AI system. Overall, patients, physicians, and nurses were strongly positive about the AI system as a support for patient-clinician communication [<xref ref-type="bibr" rid="ref87">87</xref>]. Another study described health care professionals’ perspectives [<xref ref-type="bibr" rid="ref63">63</xref>]. More specifically, it explored how emergency triage nurses understood, contextualized, and incorporated an AI-based decision support system into their work on triaging patients. Initially, nurses expressed apprehension that the AI system lacked the cultural and contextual understanding necessary for patient triage. However, they later discovered that the system helped them provide safe care [<xref ref-type="bibr" rid="ref63">63</xref>]. In total, 2% (2/86) of the studies presented health care professionals’ perspectives [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Additional studies were conducted using health care professionals as the sample population. However, these studies focused solely on health are professionals’ decision-making performance in relation to triage with AI systems, without providing insights into their perspectives [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref95">95</xref>]. In addition, 1% (1/86) of the studies portrayed citizens’ (ie, men and women aged 18-80 y) perspectives on an AI system with a conversational user interface for self-guided medical history taking [<xref ref-type="bibr" rid="ref46">46</xref>]. The citizens completed a usability test and questionnaire concerning the usability, design, and functionality of the AI system. Overall, the citizens stated that they felt comfortable with the system; however, the authors noted that the level of technical competencies and educational levels were high among the participants, limiting the generalization to patient groups [<xref ref-type="bibr" rid="ref46">46</xref>].</p>
      </sec>
      <sec>
        <title>RQ3: Stages of the Innovation Development Process (TRLs)</title>
        <p>Most (76/86, 88%) of the included studies did not demonstrate or validate AI systems for medical history taking and triage in clinical environments (ie, they were concerned with clinical problem identification; proposal of a model or solution; or model prototyping, development, or validation. These studies scored ≤5 on the TRL scale for clinical readiness [<xref ref-type="bibr" rid="ref7">7</xref>]. A few (6/86, 7%) studies scored ≥6 on the TRL scale (ie, they described real-time testing of AI models, workflow implementation, evaluation of clinical outcomes, or model integration). In total, 5% (4/86) of the studies, which were reviews of several different empirical studies, were not considered applicable to the TRL scale [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. An overview of the included studies and their TRL scores is presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Technology Readiness Level (TRL) by Fleuren et al [<xref ref-type="bibr" rid="ref7">7</xref>] of the included studies (n=82).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="100"/>
            <col width="690"/>
            <col width="210"/>
            <thead>
              <tr valign="top">
                <td>TRLs</td>
                <td>Clinical definitions</td>
                <td>Studies, n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>1</td>
                <td>Clinical problem identification</td>
                <td>0 (0)</td>
              </tr>
              <tr valign="top">
                <td>2</td>
                <td>Proposal of model or solution</td>
                <td>0 (0)</td>
              </tr>
              <tr valign="top">
                <td>3</td>
                <td>Model prototyping</td>
                <td>8 (9)</td>
              </tr>
              <tr valign="top">
                <td>4</td>
                <td>Model development</td>
                <td>50 (58)</td>
              </tr>
              <tr valign="top">
                <td>5</td>
                <td>Model validation</td>
                <td>18 (21)</td>
              </tr>
              <tr valign="top">
                <td>6</td>
                <td>Real-time model testing</td>
                <td>1 (1)</td>
              </tr>
              <tr valign="top">
                <td>7</td>
                <td>Workflow implementation</td>
                <td>2 (2)</td>
              </tr>
              <tr valign="top">
                <td>8</td>
                <td>Clinical outcome evaluation</td>
                <td>1 (1)</td>
              </tr>
              <tr valign="top">
                <td>9</td>
                <td>Model integration</td>
                <td>2 (2)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>No studies were classified as TRL 1 or 2. A small number (8/86, 9%) of studies achieved TRL 3, indicating prototyping or model development of an AI system [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref103">103</xref>,<xref ref-type="bibr" rid="ref105">105</xref>,<xref ref-type="bibr" rid="ref108">108</xref>]. Examples of studies in this category include an AI-based field triage tool [<xref ref-type="bibr" rid="ref82">82</xref>], triage of medical referrals [<xref ref-type="bibr" rid="ref105">105</xref>], and a self-diagnosis system for emergency dental care [<xref ref-type="bibr" rid="ref93">93</xref>]. A substantial number (50/86, 58%) of studies achieved TRL 4, that is, they demonstrated the potential of AI systems or optimized and validated these using clinical data. Examples of these studies include triage of adult chest radiographs [<xref ref-type="bibr" rid="ref36">36</xref>], triage using digitalized patient histories in primary care [<xref ref-type="bibr" rid="ref49">49</xref>], and triage of patients with COVID-19 under limited health care resources [<xref ref-type="bibr" rid="ref69">69</xref>]. Several (18/86, 21%) studies were categorized as TRL 5. This means that they validated AI models using realistic datasets other than the population used to train or test the AI model. This particular type of validation data was either retrospective [<xref ref-type="bibr" rid="ref48">48</xref>] or prospective [<xref ref-type="bibr" rid="ref40">40</xref>]. One study attained a TRL of 6; it investigated the testing of an AI model in real time, specifically, an algorithm for automated diabetic retinopathy screening [<xref ref-type="bibr" rid="ref28">28</xref>]. In addition, 2% (2/86) of the studies examined AI models integrated into clinical workflows and assessed their outcomes, resulting in an assessment of TRL 7 [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. The studies had a common theme of emergency care and focused on a symptom-taking tool [<xref ref-type="bibr" rid="ref87">87</xref>] and a rapid and laboratory-free COVID-19 triage [<xref ref-type="bibr" rid="ref29">29</xref>], respectively. One study achieved a score of 8 on the TRL scale, that is, it evaluated the clinical outcomes of an implemented AI model. This study examined a medical history–taking system that generated differential diagnoses in an outpatient department [<xref ref-type="bibr" rid="ref65">65</xref>]. In total, 2% (2/86) of the studies focused on the postimplementation phase of AI systems and thus achieved the TRL 9 [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. One study focused on the impact of cultural embeddedness when implementing an AI system for emergency care triage [<xref ref-type="bibr" rid="ref63">63</xref>]. Another study investigated the user demographics and levels of triage acuity of a symptom checker chatbot used within a large integrated health system [<xref ref-type="bibr" rid="ref81">81</xref>].</p>
      </sec>
      <sec>
        <title>RQ4: Facilitating Factors and Barriers to the Introduction of the AI Systems</title>
        <p>From the 6 retrieved studies that reported the introduction of AI systems for automating medical history taking and triage in health care, we identified 4 themes relating to facilitating factors and barriers to their introduction [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. The themes were related to technical aspects, contextual and cultural factors, end users, and evaluation (<xref ref-type="table" rid="table2">Table 2</xref>). The theme denoted as <italic>technical aspects</italic> pertained to the AI systems’ design, integration, requirements, and performance. The theme of <italic>contextual and cultural</italic> factors was associated with the organization and patient populations in which the AI systems were introduced. The theme <italic>end users</italic> encompassed the viewpoints and experiences of patients and health care professionals with regard to AI systems. The theme <italic>evaluation and regulation</italic> covered various aspects of evaluating, regulating, and setting guidelines for AI systems.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Facilitating factors and barriers to the introduction of artificial intelligence (AI) systems.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="160"/>
            <col width="420"/>
            <col width="420"/>
            <thead>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Facilitating factors</td>
                <td>Barriers</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Technical aspects</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Flexible design of AI system [<xref ref-type="bibr" rid="ref52">52</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Integration with existing technical systems [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Requirements of AI system [<xref ref-type="bibr" rid="ref52">52</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Insufficient performance of AI systems [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                  </list>
                  <list list-type="bullet">
                    <list-item>
                      <p>Lack of integration with existing technical systems [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Context and culture</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Understanding of a setting’s organizational context, clinical workload, and cultural competence [<xref ref-type="bibr" rid="ref63">63</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Delays in the start-up of AI systems [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Highly mixed patient populations, which was a challenge for the AI system [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>End users</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Consideration of patient’s perspectives [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Adequate training and the possibility to understand the AI system [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Innovative methods for promoting use among health care professionals [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Communication of benefits of using the AI system [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Lack the acceptance of diagnosis provided by the AI system [<xref ref-type="bibr" rid="ref65">65</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Negative receptivity among health care professionals [<xref ref-type="bibr" rid="ref63">63</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Health care professionals’ lack of time [<xref ref-type="bibr" rid="ref65">65</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Low comprehensiveness among specific patient groups [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Lack of eHealth literacy among patients [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Insufficient language skills among patients [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Low number of users [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Lack of opportunities for patients to learn how to use the system [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Evaluation</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Formulation of evaluation guidelines and regulations [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Initial and ingoing and evaluation [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>User-focused evaluation [<xref ref-type="bibr" rid="ref87">87</xref>]</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Lack of regulation and guidelines for evaluation [<xref ref-type="bibr" rid="ref57">57</xref>]</p>
                    </list-item>
                    <list-item>
                      <p>Lack of external validation [<xref ref-type="bibr" rid="ref52">52</xref>]</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>Of the 6 studies, 5 (80%) reported factors related to technical aspects of the introduction of AI systems for automating medical history taking and triage that either facilitated or hindered its introduction into clinical settings [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Technical facilitators included a flexible design that allows the AI system to be implemented in different geographical areas [<xref ref-type="bibr" rid="ref52">52</xref>]. Furthermore, doctors and nurses perceived that integrating AI systems with electronic health records would enhance their usefulness [<xref ref-type="bibr" rid="ref87">87</xref>]. Technical barriers involved the amount of information required by AI systems, which might not be possible to collect in the short time required for the triage process in emergency departments [<xref ref-type="bibr" rid="ref52">52</xref>]. An additional issue to consider was the inadequate performance of AI systems. This was due to their lack of cultural understanding of the context and the patient population they served [<xref ref-type="bibr" rid="ref63">63</xref>], limited accuracy, particularly when dealing with patients with complex presentations, such as older adults [<xref ref-type="bibr" rid="ref65">65</xref>], and the absence of optimization for certain patient groups, such as those with neurological symptoms [<xref ref-type="bibr" rid="ref87">87</xref>]. The lack of integration with established health care systems constituted an additional barrier associated with the technical attributes of the AI systems [<xref ref-type="bibr" rid="ref57">57</xref>].</p>
        <p>A total of 3 (50%) of the 6 studies reported facilitating barriers related to context and culture [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Facilitating factors included greater integration of the AI system into the clinical workflow, as nurses and physicians believed this would enhance its usefulness [<xref ref-type="bibr" rid="ref87">87</xref>]. In addition, the knowledge of the organizational context, clinical workload and culture, skills, and recognized behavior change techniques should be considered when implementing AI systems. Contextual and cultural barriers included delays in the start-up of AI systems due to strategic decision-making processes [<xref ref-type="bibr" rid="ref57">57</xref>] and the use of these systems in settings with highly mixed patient populations, such as emergency departments. This posed a challenge for AI systems, as reported by physicians, ultimately impacting their usefulness [<xref ref-type="bibr" rid="ref87">87</xref>].</p>
        <p>Of the 6 studies, 5 (80%) reported facilitating factors and barriers in relation to end users [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. The consideration of patients’ perspectives in adapting the AI system for accessibility and usefulness as well as innovative approaches to promote use among health care professionals, such as having superusers [<xref ref-type="bibr" rid="ref57">57</xref>], were identified as facilitating factors. Other factors that facilitated the introduction of AI systems for automating medical history taking and triage included providing adequate training for health care professionals, as this is crucial given the systems’ dependence on their users, and enabling them to effectively use the system [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref81">81</xref>] while also supporting patients through familiar health delivery mechanisms [<xref ref-type="bibr" rid="ref81">81</xref>]. In addition, effective communication regarding the potential benefits of AI systems in enhancing patient care, resource use [<xref ref-type="bibr" rid="ref52">52</xref>], and patient outcomes [<xref ref-type="bibr" rid="ref63">63</xref>] was found to facilitate their adoption. Notably, the significance of the latter aspect was emphasized for its widespread uptake [<xref ref-type="bibr" rid="ref63">63</xref>]. End-user barriers to the uptake of the AI system included physicians’ nonacceptance of AI-generated diagnosis [<xref ref-type="bibr" rid="ref65">65</xref>], negative receptivity toward rapid implementation [<xref ref-type="bibr" rid="ref63">63</xref>], and health care professionals constrained by limited time to use the AI system [<xref ref-type="bibr" rid="ref87">87</xref>]. In addition, a lack of comprehension among certain patient groups (such as those with neurological symptoms), inadequate eHealth literacy [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], linguistic deficiencies in patients (specifically, in expressing complaints in a way that the AI system can understand) [<xref ref-type="bibr" rid="ref87">87</xref>], and limited opportunities for patients to acquire the necessary skills to use AI tools, due to limited occasions for using it [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], were additional barriers linked to end users.</p>
        <p>Facilitating factors and barriers related to evaluation were reported in 50% (3/6) of the studies [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Factors suggested to facilitate the introduction of AI systems were the formulation and implementation of evaluation guidelines and regulations to ease the development and use of AI systems [<xref ref-type="bibr" rid="ref57">57</xref>]. Initial and ongoing assessments of AI systems and evaluations focused on users were facilitating factors for assessing the safety and effectiveness of introducing AI systems in complex environments [<xref ref-type="bibr" rid="ref87">87</xref>]. Barriers related to evaluation included the current lack of evaluation regulations and guidelines [<xref ref-type="bibr" rid="ref57">57</xref>] as well as the validation of AI systems [<xref ref-type="bibr" rid="ref52">52</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>The goal of this study was to analyze and compile existing empirical studies on AI systems used for automating medical history taking and triage in health care. This review shows that research on AI systems to automate medical history taking and triage in clinical settings is still at an early stage, articulating a large gap to be bridged between model development and the bedside, similar to what has been highlighted in previous research on AI in health care [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref115">115</xref>,<xref ref-type="bibr" rid="ref116">116</xref>]. There is a paucity of studies demonstrating AI systems to automate medical history taking and triage in clinical settings, representing the perspectives of patients or health care professionals, and providing information on facilitators and barriers to the introduction of these AI systems. The findings on the state of research in this area should be understood in light of some of the characteristics of the included research studies, indicating that research on AI systems to automate medical history taking and triage in health care remains relatively new and underdeveloped, and is mainly conducted in a nonclinical research environment of prototyping, development, and validation. While it is crucial to establish a solid research foundation that tests and validates AI systems before their implementation in clinical settings, which could potentially impact care quality, safety, clinical outcomes, and working conditions for health care professionals, it is also essential to conduct research that puts these systems into practical use to showcase their potential [<xref ref-type="bibr" rid="ref117">117</xref>]. However, the current level of research on AI systems for automating medical history taking and triage remains inadequate.</p>
      </sec>
      <sec>
        <title>Characteristics of the Research Publications</title>
        <p>The study revealed a notable surge in research on AI systems for automating medical history taking and triage over the past 3 years, indicating a growing interest in leveraging AI technologies in relation to managing patient flows in health care settings. Geographically, research was predominantly concentrated in Asia, North America, and Europe, aligning with regions known for both advanced health care infrastructure and research capabilities. The prevalence of studies focusing on emergency and primary care underscores the potential of AI systems to automate medical history taking and triage in first-line care, which globally faces challenges in meeting the needs of the people it is intended to serve [<xref ref-type="bibr" rid="ref118">118</xref>,<xref ref-type="bibr" rid="ref119">119</xref>]. Many (12/86, 14%) studies also focused on radiology, illustrating the potential of AI systems to assist radiologists in image triage, a finding that is not surprising, given the progress of AI in image recognition tasks [<xref ref-type="bibr" rid="ref120">120</xref>]. However, a significant (15/86, 17%) proportion of studies did not specify the clinical context, suggesting the need for more context-specific investigations to better understand the applicability of AI systems for medical history taking and triage. A large number (31/86, 36%) of studies also had a retrospective design, which, together with the large group of non-context–specific studies, may indicate a trend toward horizontal research rather than toward the implementation of AI systems for automating medical history taking and triage in clinical settings. As previous studies have suggested, this type of research and development may be partly due to the challenges of conducting studies that actually implement AI in real clinical settings [<xref ref-type="bibr" rid="ref116">116</xref>]. The most common type of AI system was hybrid models that performed tasks related to forecasting or recognition. These findings resonate with previous research on the ways in which machine learning has been used to predict the flow of patients through health care systems [<xref ref-type="bibr" rid="ref3">3</xref>]. Most (70/86, 81%) studies used patient datasets as their sample population, comprising patient records that were used to test, validate, and prototype AI models. This also meant that they focused on the technical capabilities of AI systems to automate medical history taking and triage based on a specific set of patient records, rather than their usability for health care professionals or patients.</p>
      </sec>
      <sec>
        <title>Perspectives Described in the Publications (Among Researchers, Health Care Professionals, or Patients)</title>
        <p>While the promise of AI systems for automating medical history taking and triage to transform health care is well recognized, this study highlights an imbalance in stakeholder perspectives in the current research. Researchers’ viewpoints overwhelmingly dominated the literature. Despite providing insights into the description and interpretation of AI systems designed for medical history taking and triage, there has been limited exploration of the critical viewpoints stemming from patients and health care professionals regarding their practical application in clinical settings. Previous research has argued that the imbalance between different stakeholder groups’ perspectives in research on AI in health care should be addressed to meet the distinct needs of different groups [<xref ref-type="bibr" rid="ref121">121</xref>]. Furthermore, the importance of the acceptability of interventions in routine health care practice is widely recognized in the fields of intervention, innovation, implementation, and improvement science [<xref ref-type="bibr" rid="ref117">117</xref>]. Therefore, it is essential to consider the views of patients and health care professionals regarding the use of AI systems to automate medical history taking and triage. This will help to ensure the successful implementation of these systems. The positive feedback from patients on usability and support in patient-clinician communication from AI systems for automating medical history taking and triage emphasizes the potential benefits of involving patients in the design and evaluation of such systems. Previous research investigating a rule-based, automated medical history–taking app [<xref ref-type="bibr" rid="ref122">122</xref>] even deemed patient involvement in the development process of these types of tools necessary. One additional study delved into health care professionals’ perspectives, focusing on concerns and adjustments when integrating AI systems for automating medical history taking and triage into the triaging processes. The study found that nurses were uneasy with the AI system’s acontextual nature [<xref ref-type="bibr" rid="ref63">63</xref>]. To increase trust in AI systems, researchers suggest that focusing solely on technical aspects, such as objectivity, efficiency, and accuracy, is insufficient. AI systems must also be aligned with the values and principles of the clinical environment in which they are used. This is crucial because people are more inclined to trust and embrace AI systems when they perceive them as aligning with the inherent value, significance, and utility of the context in which they are deployed [<xref ref-type="bibr" rid="ref123">123</xref>].</p>
      </sec>
      <sec>
        <title>Stages of the Innovation Development Process: TRLs</title>
        <p>The application of the TRL framework [<xref ref-type="bibr" rid="ref7">7</xref>] provided a structured understanding of AI systems for automating medical history taking and triage development stages. Most (76/86, 88%) studies focused on lower TRLs, which aligns with the prevalence of studies that emphasize developmental work and potential demonstrations in the broader field of applying AI in health care [<xref ref-type="bibr" rid="ref15">15</xref>]. This disparity underscores a critical gap in our understanding. This highlights the pressing need for more comprehensive investigations into the practical implementation and validation of AI systems in real health care settings. These higher TRL evaluations are pivotal in ensuring that AI technologies not only show promise in controlled environments but also prove their effectiveness and reliability when deployed in complex and dynamic safety-critical settings in health care practice [<xref ref-type="bibr" rid="ref124">124</xref>]. Such research can contribute significantly to building trust and confidence in AI systems within the medical domain and promoting their implementation and use in practice.</p>
      </sec>
      <sec>
        <title>Facilitating Factors and Barriers to the Introduction of AI Systems</title>
        <p>The introduction of AI systems for automating medical history taking and triage is a complex process influenced by several factors, both hindering and facilitating its implementation. One set of barriers described lies in technical aspects, encompassing system performance and integration. The effectiveness and seamless integration of these AI systems into existing health care workflows will significantly impact their adoption and use. In addition to the technical issues, contextual and cultural factors are also important. The organizational context within health care settings as well as the diversity of patient populations shaped adoption. Different health care institutions, stakeholder roles, and patient perspectives may have unique requirements and expectations regarding AI integration in health care [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref125">125</xref>]. Recognizing the importance of stakeholder and patient perspectives highlights the need for tailoring AI systems to cater to context- and situation-specific needs and concerns [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref126">126</xref>,<xref ref-type="bibr" rid="ref127">127</xref>]. Regulatory and evaluative considerations add another layer of complexity to the integration process. The development of guidelines and user-focused evaluations is essential to ensure the safety, efficacy, and ethical use of AI systems in health care [<xref ref-type="bibr" rid="ref128">128</xref>-<xref ref-type="bibr" rid="ref130">130</xref>]. These considerations underscore the need for a well-structured and carefully monitored approach to the implementation of AI in medical history taking and triage.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The study’s strengths include a thorough review of records with rigorous screening. The search strategy covered 5 electronic databases, ensuring comprehensiveness. However, it missed the opportunity to explore gray literature, which could have revealed additional cases that may present ongoing or completed work not yet in the research literature. We decided not to include conference proceedings in this review due to their often preliminary nature and limited analysis [<xref ref-type="bibr" rid="ref26">26</xref>]. Upon examining the conference papers identified in the search, it became evident that they represented a diverse array of formats and scopes and varied significantly in how they were quality assessed and made accessible. This heterogeneity posed a challenge for their integration into a pooled analysis alongside more uniform and rigorously peer-reviewed papers. Nevertheless, in instances where the evidence is limited or contradictory, which is often the case in research on AI, the incorporation of conference proceedings can prove advantageous for systematic reviews [<xref ref-type="bibr" rid="ref26">26</xref>]. Therefore, it is recommended that future reviews in this domain of research consider the incorporation of high-quality conference proceedings. We did not manually search the reference lists of the included studies to add more content to the search because an as stringent as possible review of the current literature was sought. Identifying studies focusing on AI systems can be a complex task due to the lack of consensus on their definition. To ensure clarity for the reader, we have aimed to be transparent about how we define AI systems in this review. To maintain clarity, we based our inclusion on how the original authors described their systems as AI, relying on their accuracy. Because AI definitions vary, this introduces subjectivity, potentially affecting the consistency and comparability of the included articles. We suggest that future research consider this challenge in greater depth. We used a search strategy similar to that used in previous scoping reviews to identify AI systems [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. The studies reviewed in this study concentrate on medical history taking and triage, both crucial processes for managing patient flow by assessing a patient’s condition and referring them to the appropriate care. However, it is important to note that this approach may have some limitations. Therefore, we recommend that future research conduct separate literature reviews for each of these patient flow management processes. The eligibility criteria for study publication dates were set to identify any early studies on the topic of this review, despite AI applications in health care being a more recent phenomenon [<xref ref-type="bibr" rid="ref131">131</xref>]. To ensure consistency, all full-text screening decisions were confirmed in pairs and discussed at biweekly meetings. This approach encouraged open discussions to address doubts, exclusion criteria, and differing interpretations. Conflicting interpretations and uncertainties were resolved through discussion.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This scoping review contributes to the understanding of AI system implementation in health care by providing insights into current trends, stakeholder perspectives, innovation development stages, and influencing factors. It highlights gaps in patient perspectives and the underrepresentation of higher TRLs, indicating opportunities for further research. To realize the full potential of AI systems for automating medical history taking and triage in health care settings, it is crucial to integrate patients’ voices into AI development, enhance real-world validation, and address the multifaceted challenges highlighted by end users and regulations. As health care systems evolve, embracing AI technologies while ensuring alignment with clinical and patient needs remains a key challenge for future research and implementation efforts. These multifaceted factors collectively shape the landscape of AI system adoption in the context of automating medical history taking and triage. Therefore, a holistic and inclusive approach is necessary to ensure the effectiveness and ethical use of these types of AI systems.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist.</p>
        <media xlink:href="jmir_v27i1e53741_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 530 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategy.</p>
        <media xlink:href="jmir_v27i1e53741_app2.docx" xlink:title="DOCX File , 20 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Characteristics of the included studies.</p>
        <media xlink:href="jmir_v27i1e53741_app3.docx" xlink:title="DOCX File , 194 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AI</term>
          <def>
            <p>artificial intelligence</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">RQ</term>
          <def>
            <p>research question</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">TRL</term>
          <def>
            <p>Technology Readiness Level</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This project has received funding from the Swedish Innovation Agency and the Knowledge Foundation.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>All data generated or analyzed during this study are included in this published article and its supplementary information files.</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>Study conception and design were formulated by ES and JN. ES and HJ were responsible for data collection. ES, HJ, and JN contributed to the analysis and interpretation of results. All authors collaborated in the preparation of the draft and approved the final version of the paper.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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