Chronic diseases were responsible for >70% of deaths worldwide in 2019, making them the leading cause of mortality and morbidity [1]. In the Middle East and North Africa (MENA) region [2], chronic conditions accounted for 79% of deaths in 2020 [3]. Although there are many factors contributing to the prevalence of chronic diseases, physical inactivity and sedentary behaviors are well-established risk factors [4-8]. Worldwide studies have revealed that the MENA region has higher rates of physical inactivity compared with the global average, with 32.8% of adults and 85% of adolescents considered insufficiently active compared with 28% of adults and 81% of adolescents worldwide [9,10].

There are specific factors unique to the MENA region that might influence physical inactivity and sedentary behaviors, such as environmental conditions or infrastructure. Specifically, extreme weather conditions, particularly during the hot summer months, can make outdoor exercise uncomfortable or even hazardous [11,12]. Limited access to sports facilities is another barrier to physical activity, and high urbanization associated with dependence on motor vehicles likely increases sedentary time [11,12]. Given these regional factors, interventions targeting physical activity and sedentary behaviors in the MENA region need to be tailored to a regional and population context.

Mobile interventions such as mobile apps, fitness trackers, and SMS text messages can be a powerful tool for promoting physical activity and reducing sedentary behaviors. The high mobile penetration rate in the MENA region [13,14] makes mobile technologies a possible solution for delivering large-scale real-time interventions. Moreover, the advanced capability of these technologies to automate and process data can allow interventions to be tailored according to the specific individual, context, and region [15-18]. Mobile apps or fitness trackers can also incorporate theory-based behavior change techniques that are known to be effective [19], such as automating self-monitoring of activity and providing feedback or allowing users to set goals.

Despite this potential, to date, little is known about the effectiveness of mobile technologies targeting physical activity and sedentary behaviors in the MENA region. Although some systematic reviews have reported a positive effect of mobile technologies on behavioral outcomes [18,20-31], none of these studies have focused on evidence from the MENA region. A systematic review explored physical activity interventions in 6 Arabian Gulf countries (ie, Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates) [32]—a subset of the MENA region—but did not solely focus on mobile interventions or explore interventions for sedentariness. Thus, it remains unclear whether mobile technologies are particularly effective in changing physical activity and sedentary behaviors in the MENA region. In addition, given the unique barriers that the MENA population faces, there is also a need to understand users’ acceptability and the implementation outcomes of these mobile interventions (eg, the appropriateness or cultural fit of the interventions). Finally, it is worth noting that there is diversity among the countries in the MENA region regarding income level, economic and social stability [2], and mobile penetration rate [14]. Socioeconomic disparities have been linked to inequitable access to technologies and varying levels of digital literacy, creating a “digital divide” [33-35]. Understanding the geographical scope of mobile health research in the MENA region is crucial to gauge whether findings are applicable across the region and identify potential signs of a digital divide.

The aim of this systematic review and meta-analysis was to summarize the characteristics and evaluate the effectiveness of mobile interventions targeting physical activity and sedentary behaviors in the MENA region. A secondary aim was to explore users’ perspectives on these interventions as well as any other outcomes that might influence users’ adoption and use of mobile technologies (eg, appropriateness and cultural fit).

A systematic search of the literature was conducted in MEDLINE, Embase, CINAHL, Scopus, and Global Index Medicus from database inception to January 19, 2023. The search strategy was developed after consultation with a research librarian and comprised three strings: (1) mobile technology terms, (2) physical activity and sedentary behavior terms, and (3) MENA countries (Multimedia Appendix 2). The reference lists of relevant articles and other reviews on similar topics were also screened to ensure that all eligible studies were captured. A gray literature search was performed using Google Scholar. We contacted the authors to obtain additional information when needed. We also contacted the authors to request the full text when it was not available. If the authors did not provide the full text, we excluded the studies.

We included studies that met the following population, intervention, comparator, outcome, and study design criteria: (1) participants of all ages regardless of medical condition, (2) interventions that used mobile technologies (ie, mobile apps, fitness trackers, or SMS text messages), (3) presence or absence of a comparator, (4) any outcomes related to physical activity or sedentary behaviors (eg, active minutes and sitting time) or to users’ perceptions of mobile technologies, (5) conducted in MENA countries as listed by the World Bank [2], and (6) primary research studies (eg, randomized controlled trials [RCTs], quasi-experimental studies, or qualitative studies). Studies in all languages were included.

Studies were excluded if (1) the intervention did not have a mobile technology component (eg, web-based only) or (2) they only reported measures related to physical function (eg, sit-to-stand test). Multimedia Appendix 3 [2,20,37] provides a detailed outline of the eligibility criteria.

The screening procedure was piloted before beginning. In total, 4 pairs of investigators independently conducted a 2-phase screening using Rayyan (Rayyan Systems, Inc) [38] for title and abstract and full text. Disagreements were resolved through discussion.

The data extraction form was developed in Microsoft Excel (Microsoft Corp) and piloted before extraction. The following data were collected for each study: author; year; country; study design; study population, sample size, participant demographics, and baseline characteristics; details of the intervention and control conditions; retention rates (ie, percentage that completed the follow-up assessment); outcomes and times of measurement; and source of funding and conflicts of interest. Data were extracted by one researcher and checked for accuracy by another. RCTs were assessed by 2 independent researchers using the Cochrane risk-of-bias tool [39], and disagreements were resolved through discussion. To assess outcome reporting bias, we compared the outcomes specified in the trial protocols with the outcomes reported in the corresponding trial publications; if the trial protocols were unavailable, we compared the outcomes reported in the methods and results sections of the trial publications. Quality assessment of the rest of the included studies was completed using the Joanna Briggs Institute (JBI) critical appraisal tools, including the checklists for quasi-experimental studies, cross-sectional studies, and qualitative research [40].

A narrative synthesis was conducted of all included studies. A meta-analysis was conducted for RCTs in which the control group did not have a mobile technology component. This was because the study aimed to examine the effectiveness of mobile technologies on physical activity or sedentary behaviors compared with nonmobile interventions. Cluster randomized trials were also included in the meta-analysis by calculating the effective sample size using the Cochrane guideline [41] (Multimedia Appendix 4 [42,43]). We planned to perform 2 separate meta-analyses to combine outcome measures of physical activity and sedentary behaviors. However, only 2 trials measured sedentary behaviors; given this small number, a meta-analysis was used to combine physical activity outcomes only. Sedentary outcomes were summarized narratively.

Whenever a single study reported multiple outcomes for the same behavior (eg, reporting both daily step count and daily active minutes for physical activity), the outcome that was included in the meta-analysis was selected through the consensus of the authors favoring (1) the included studies’ primary outcomes, (2) the most meaningful outcomes to intended users (eg, step count), and (3) the longest follow-up. All reported outcomes (from data collected after the intervention) were pooled, and all effect sizes were transformed into standardized mean differences. We used a random-effects model for all analyses; the restricted maximum likelihood estimator was used to calculate the heterogeneity variance (τ²). To assess heterogeneity, I² was used.

The presence and potential impact of publication bias were explored using a funnel plot, the Egger test, and the trim-and-fill method by Duval and Tweedie [44]. In total, 2 sensitivity analyses were conducted including only (1) studies that were randomized at the individual level and (2) studies that had a low risk of bias in at least 3 out of 5 categories. Owing to an insufficient number of studies, a planned meta-regression was not conducted. We used the Grading of Recommendations Assessment, Development, and Evaluation system for grading the body of evidence [45]. All computations were conducted in R (version 4.2.3; R Foundation for Statistical Computing) [46]. The 2-tailed significance level for all statistical tests was set at P<.05.

The search retrieved 2038 unique articles (Figure 1). After abstract and full-text screening, 23 articles were included. Multimedia Appendix 5 provides a list of excluded studies at full-text screening. In total, 2 articles were found through the reference lists of relevant articles, and 2 were included from the Google Scholar search. Finally, the systematic review included 27 articles: 11 (41%) articles describing 10 unique RCT studies (n=2, 20% cluster RCTs [42,43,47]) [42,43,47-55], 12 (44%) quasi-experimental studies [56-67], 3 (11%) surveys [68-70], and 1 (4%) interview study [71] (Tables 1-3).

Most of the included studies were conducted in Iran [50-52,54,55,57,59,62,64,65] (10/27, 37%) or Saudi Arabia [42,49,56,58,63,66,68,70] (8/27, 30%). In total, 7% (2/27) of the studies were conducted in Jordan [48,53] and Oman [43,47], and 4% (1/27) of the studies were conducted in Egypt [61], Kuwait [71], Lebanon [69], Qatar [60], and the United Arab Emirates each [67]. The included studies were published between 2012 and 2023. The average duration of experimental studies was 20 (SD 14.4; range 6-52) weeks. The total number of participants was 6141 (1/27, 4% of the studies had 2600 participants). Among the study participants, 46% were women; 7% (2/27) of the studies did not report gender distribution [60,71]. A total of 33% (9/27) of the studies were conducted in populations with chronic conditions, including cardiovascular diseases [48,53,61], diabetes [54,58,59,64,66], and sleep problems [70]. The funding sources and conflicts of interest are summarized in Multimedia Appendix 6 [42,43,47-71].

The risk of bias was assessed as low in 3 out of 5 categories in half (5/10, 50%) of the included RCTs [43,48,50,53,55] (Table 4). Half (5/10, 50%) of the included RCTs described a low-risk randomization process [48,51-53,55]. In 20% (2/10) of the trials, the allocation sequence was not concealed until participants were enrolled [42,49]. Of the 10 RCTs, 2 (20%) cluster RCTs were assessed as low risk in an additional domain (ie, “timing of identification or recruitment of participants”). The risk of “deviations from intended interventions” was assessed as low in 40% (4/10) of the studies [43,50,53,55], there were “some concerns” in 40% (4/10) of the studies [42,48,51,52], and the risk was high in 20% (2/10) of the studies as an appropriate analysis (eg, intention-to-treat) was not used. Half (5/10, 50%) of the included RCTs had a low level of incomplete data [42,43,47,48,55], whereas the other half were assessed as having some concerns [49,51-54]. Most of the studies (7/10, 70%) were assessed as having some concerns regarding the measurement of the outcomes because of the self-report nature, and participants (ie, outcome assessors in this case) were aware of the intervention allocation [43,49-51,53-55]. More than half (6/10, 60%) of the included studies scored as having a low risk in the selection of the reported results [43,49-51,53,55], whereas 40% (4/10) of the studies were assessed as having some concerns because of the lack of details regarding a preplanned analysis [42,48,52,54].

Table 5 provides a summary of the quality assessment of the quasi-experimental studies using the JBI checklist for quasi-experiments. All 12 quasi-experimental studies [56-67] made clear what was the cause versus the effect (question 1), had multiple measurements of the outcome both before and after the intervention (question 5), and measured the outcomes of participants in the comparison groups in the same way as those of participants in the intervention groups (question 7). In all except one study (11/12, 92%) where this was unclear [67], participants in the comparison group were similar to participants in the intervention group. In one study [65], it was unclear whether participants in the comparison group received similar treatment; the other 92% (11/12) of the studies met this criterion (question 3). In half (6/12, 50%) of the studies, there was no control group (question 4). Only 8% (1/12) of the studies provided information about whether follow-up was complete and how follow-up data were treated [62] (question 6). In total, 83% (10/12) of the studies measured outcomes in a reliable way; this information was unclear in 17% (2/12) of the studies [57,61] (question 8). Appropriate statistical analyses were conducted in 92% (11/12) of the studies; this was unclear in 8% (1/12) of the studies [61] (question 9).

The survey studies (3/27, 11%) [68-70] were assessed using the JBI checklist for cross-sectional studies (Table 6). The criteria for inclusion were not clearly defined in those 3 studies (question 1). The study participants and settings were described in detail in 67% (2/3) of the studies [68,69] (question 2). Owing to poor reporting, it was unclear in all 3 studies whether exposure and outcomes were measured in a valid and reliable way (questions 3 and 7) and whether confounding factors and strategies to deal with them were identified (questions 5 and 6). In 33% (1/3) of the studies, appropriate statistical analysis was used (question 9).

The interview study [71] was assessed using the JBI checklist for qualitative research. It was assessed as meeting the criteria in 5 domains (ie, congruity between the research methodology and the research question, congruity between the research methodology and the methods to collect data, congruity between the research methodology and the representation and analysis of data, representation of participants and their voices, and ethics approval by an appropriate body). In total, 3 domains were unclear (ie, congruity between the stated philosophical perspective and the research methodology, congruity between the research methodology and the interpretation of results, and the relationship between the conclusions and the analysis or interpretation of the data). There was no statement locating the researcher culturally or theoretically or on the influence of the researcher on the study.

Of the 10 included RCTs, 7 (70%) were deemed eligible for inclusion in the meta-analysis of physical activity outcomes. Specifically, 20% (2/10) of the RCTs were excluded because they had a mobile component in the control arm [48,55], and 10% (1/10) were excluded for only reporting behavioral practices regarding diabetes care (combining physical activity and other health measures) [54]. In line with the strategies for data synthesis, for 71% (5/7) of the studies [43,49-52], the measures of metabolic equivalent of task minutes per week were included in the meta-analysis; for the other 29% (2/7) of the studies, the duration of moderate to vigorous physical activity was included [42,53].

The meta-analysis showed a positive effect of mobile interventions on physical activity outcomes (standardized mean difference=0.45, 95% CI 0.17-0.73; Figure 2 [42,43,49-53]). The I² was 74%, indicating a high heterogeneity. One study in particular [42] seemed to be the source of high heterogeneity. This was the only study that delivered an intervention in the workplace, with part of the intervention including regular computer prompts throughout the day. The high frequency of the computer prompts might have had an effect on behavior changes. The funnel plot appeared to indicate signs of publication bias (Multimedia Appendix 8). The Egger test had an intercept of 3.65 (P=.02), indicating possible publication bias. The trim-and-fill method imputed an effect size of 0.30 (95% CI −0.65 to 1.25), indicating a possible nonsignificant effect. In total, 3 sensitivity analyses were conducted, including only (1) studies that were randomized at the individual level and (2) studies that had a low risk of bias in at least 3 categories and excluding the study by Quronfulah [42] as an outlier. All 3 sensitivity analyses showed a statistically significant positive result for physical activity (P<.05; Multimedia Appendix 9). Subgroup analyses were conducted among studies with patients who were chronically ill and studies with healthy individuals; both reported nonsignificant changes in physical activity (Multimedia Appendix 9). Only 20% (2/10) of the RCTs reported measures regarding sedentary behaviors; both reported a greater reduction in sedentary time in the intervention group than in the control group [42,43] (Multimedia Appendix 7).

Quasi-experiments were not included in the meta-analysis because of the generally lower quality and lack of a control group. Over half (7/12, 58%) of the quasi-experiments reported significant changes in physical activity [57,58,61,62,64,65,67]. Other anthropometric (eg, BMI and weight) or clinical (eg, glycated hemoglobin) outcomes were also reported (Table 2). It is worth noting that most experimental studies (19/22, 86%) measured physical activity outcomes using a validated questionnaire (eg, the International Physical Activity Questionnaire); only 20% (2/10) of the RCTs [42,43] and 8% (1/12) of the quasi-experiments [48] (3/27, 11% in total) used an objective method (eg, accelerometer).

Our review revealed that the use of mobile technologies for physical activity and sedentary behaviors in the MENA region is at an early stage of research given the predominance of small and heterogeneous studies and very few RCTs. The meta-analysis provided preliminary evidence of a small to moderate positive effect of mobile interventions on physical activity in the short term; only 7% (2/27) of the studies measured sedentary behaviors, reporting positive outcomes from the interventions. It is important to note that this evidence is of low to moderate quality according to the Grading of Recommendations Assessment, Development, and Evaluation system [45] because of the high risk of bias in half (5/10, 50%) of the assessed RCTs, heterogeneity in intervention delivery and context, short study duration, possible small-study effects, and publication bias. The reporting standards of the included studies varied widely, and only a small number of studies (3/22, 14%) provided metrics of engagement with the mobile interventions. Nonexperimental studies revealed that users mainly used mobile apps and fitness trackers for self-monitoring of physical activity. Users also revealed several barriers to technology adoption; few studies (1/27, 4%) evaluated the implementation outcomes (eg, context-specific or cultural appropriateness) of the interventions.

This systematic review and meta-analysis focused on the MENA region and provided insights into the effectiveness of mobile technologies on physical activity and sedentary behaviors. Similar to the findings of our meta-analysis, a number of systematic reviews have found a small to moderate effect of mobile technologies on behavioral outcomes [18,20-31]; however, these reviews did not focus on a specific region, and thus, evidence applicable to the MENA region was limited. Furthermore, as these reviews were not MENA specific, it is unclear what would be the most promising interventions given the unique barriers that the MENA region faces. Our review found that particularly favorable interventions were those that conducted user needs assessments, considered daily lives and cultural contexts, and had multicomponent approaches. These findings are in line with those of a review focused on the Asian population that found that Asian apps are largely culturally adapted and multifunctional [72]. A few reviews have explored the use of technologies in specific regions, such as low- and middle-income countries or Asia [72,73], which also showed promising evidence of using these technologies for physical activity and other behavior changes. One systematic review explored physical activity interventions in only 6 Arabian Gulf countries [32] and did not exclusively examine mobile interventions or explore interventions for sedentariness. This review found limited evidence suggesting that pedometer-based interventions encouraging step counting and walking were effective in promoting physical activity, which might suggest the potential of using mobile technologies that can automate self-monitoring of behavior [32]. Thus, our review expands on existing evidence by investigating the use of mobile interventions in MENA countries for both physical activity and sedentary behaviors and, hence, is able to assess whether mobile technologies were effective for this population and what the users’ perspectives were. Combined with the findings from previous reviews, there is evidence suggesting that mobile technologies might be helpful in changing physical activity; however, these interventions likely need to be tailored to users’ daily lives and cultural contexts.

Our meta-analysis suggests that mobile technologies may be promising for changing physical activity and sedentary behavior in the MENA region. Particularly favorable interventions were those that conducted user needs assessments, considered daily lives and cultural contexts, and had multicomponent approaches. For example, one study assessed users’ preferred method of communication and intervention frequency to tailor the design accordingly, resulting in a high level of acceptability and perceived usefulness [42]. Interestingly, WhatsApp was identified as a preferred platform and used in several studies to deliver educational content or send reminders [43,47,49,57,58]. Conducting needs assessments during intervention development will allow researchers and policy makers to determine whether existing technologies can be leveraged or whether additional apps or features are required to meet users’ needs. Incorporating cultural contexts, such as scheduling intervention messages during cultural or health events (eg, Ramadhan and World Hypertension Day) [43], was also a promising approach. In addition, successful interventions combined mobile technologies with face-to-face consultations, suggesting that mobile technologies can complement the role of periodic in-person consultations by delivering more frequent support in daily contexts. It is worth noting that, in the meta-analysis, studies that had a true control group also tended to report larger effect sizes and significant results. Overall, our findings emphasize the potential of mobile technologies to promote behavior changes in the MENA region, necessitating strategies that consider user needs, cultural fit, and multicomponent approaches.

Our review revealed several gaps involving country-specific contexts, targeted populations, and behaviors that should be addressed by researchers and policy makers. First, two-thirds of the included studies (18/27, 67%) were conducted in Saudi Arabia and Iran, and thus, evidence on the use of mobile technologies in other MENA countries was limited. It is likely that more research has been conducted in stable and high-income countries given the diversity of countries in the MENA region regarding income level, economic and social stability [2], and mobile penetration rate [14]. This finding flags the issues of equitable access to mobile technologies across the region, potentially worsening the digital divide and widening health gaps [33-35]. The benefits of mobile health will be limited if it can only reach people with a high socioeconomic status. Thus, concentrated efforts are essential to increase technology access across the region and promote broader research initiatives across countries and contexts.

Second, evidence on mobile interventions for children and adolescents remains limited, with only one included intervention targeting mothers with the ultimate aim of changing preschoolers’ physical activity and diet. Given the importance of promoting healthy behaviors from an early age, policy makers should invest in the development and evaluation of mobile interventions for children and adolescents in the MENA region. Third, only 7% (2/27) of the studies intervened on and measured sedentary behaviors, highlighting the need for future research and investment from policy makers to address sedentariness so as to holistically address inactive lifestyles.

In addition, none of the experimental studies examined fitness trackers as part of the intervention despite interest in these devices (as reported in 2/4, 50% of the nonexperimental studies [69,71]) and existing evidence of their positive effects on physical activity [18,20,22,23,25]. Finally, most RCTs (7/10, 70%) measured behavioral outcomes using self-reporting methods (eg, validated questionnaires). Future research might consider using objective measures provided by mobile apps and fitness trackers, which can improve the accuracy and reliability of the data and provide more robust evidence for policy decision-making.

The reporting standards of the included studies in our review varied greatly, with few details provided regarding the intervention, study procedure, and methodology in some studies. Notably, few of the included experimental studies (3/22, 14%) assessed user engagement even though a large body of research has suggested that engagement with digital interventions is a precondition for effectiveness and highlighted issues of high dropout or nonuse attrition in mobile interventions. Future studies should adhere to reporting guidelines (eg, CONSORT [Consolidated Standards of Reporting Trials], STROBE [Strengthening the Reporting of Observational Studies in Epidemiology], and COREQ [Consolidated Criteria for Reporting Qualitative Research]) [74-76] to enable evidence synthesis and assess engagement metrics consistently to allow for future evaluation of the right “dose” of use of these mobile technologies for effectiveness.

Finally, our review also identified qualitative evidence on barriers to adoption and user preferences that policy makers and researchers should consider. Factors such as perceived lack of usefulness, loss of interest, and technical issues can hinder the effectiveness of mobile interventions [77,78]. In addition, although some participants mentioned a preference for intervention material being culturally and linguistically adapted, few studies (1/27, 4%) examined the context fit or cultural appropriateness of the interventions, highlighting the need for future evaluation of these implementation outcomes.

Our study has several strengths. We followed a prespecified protocol registered in the PROSPERO database. Our search included peer-reviewed and gray literature. We also hand searched related reviews to ensure that relevant studies were captured. Data extraction and risk-of-bias assessment were conducted by 2 reviewers, and the authors were contacted for additional information. Finally, we conducted several sensitivity analyses (which were consistent with our main results) and assessed risk of bias and publication bias to better understand the limitations of our findings.

Our findings should be interpreted within the context of the study’s limitations. The poor reporting of the included studies affected our synthesis capability. Owing to the small number of studies targeting sedentary behaviors, it was not possible to conduct a meta-analysis of this behavioral outcome. The meta-analysis findings were affected by the quality of the included studies, including a large proportion of self-reported outcomes, small sample sizes, and possible publication bias. Our data synthesis strategy selected one outcome from each study to be included in the meta-analysis; future research might consider performing a multilevel meta-analysis to include all reported outcomes of the studies [79]. In addition, as most of the included studies (18/27, 67%) were conducted in Saudi Arabia or Iran, it is important to acknowledge the potential limitations in generalizing the findings to other countries in the MENA region. However, the insights derived from this review can still serve as a valuable guide for future research endeavors and inform policy-making processes in other MENA countries.

Our findings have important implications for policy, practice, and future research in the MENA region. First, regarding policy implications, policy makers should support and fund RCTs with longer durations to determine the long-term effectiveness of mobile technologies on physical activity and sedentary behavior. Investment should also be made in technology infrastructure and research initiatives in countries with lower socioeconomic status to promote equitable access to mobile technologies across the MENA region. In addition, policy makers need to ensure that interventions are culturally sensitive and linguistically adapted to enhance their acceptability and effectiveness. Finally, it is important to recognize that mobile technologies alone are unlikely to address behavioral challenges in the MENA region given the variability in mobile ownership and social and economic conditions [2,14,80,81]. Thus, policy makers will need to direct efforts into designing and evaluating multifaceted interventions that can appropriately target physical activity and sedentary behaviors while considering the diverse country contexts.

The evidence of the preliminary effectiveness of mobile interventions found in this review needs to be supported by future rigorous evaluations, with the ultimate goal of assisting clinical practice. If there is sufficient, high-quality evidence, clinicians may consider discussing the use of mobile interventions with people who need to change their activity levels as part of a shared decision-making process [82,83]. Potentially, mobile technologies can enhance patient-clinician collaboration by capturing data to facilitate period review while also empowering individuals to manage their health more actively [84]. As research in the MENA region continues to evolve, evidence of the effectiveness of mobile technologies can be used to determine whether their use can become part of routine clinical care. It is important to note that, although technology prescription is a promising prospect, clinicians have reported several barriers to this practice—the most prominent concern being the lack of knowledge of prescribable technologies and lack of reliable sources to access this information [85,86]. Therefore, a nationally accessible repository of vetted and curated technologies for health care professionals is needed to promote the sustainability and scalability of mobile technologies in clinical practice [85,86].

Implications for future research encompass the need for well-designed RCTs, adherence to reporting standards, and assessment of implementation outcomes. First, well-designed and fully powered RCTs are needed to provide high-quality evidence on the effectiveness of mobile technologies on physical activity and sedentary behaviors, especially over a long-term follow-up. Second, it is crucial for future studies to adhere to existing reporting guidelines [74,75,87] to facilitate evidence synthesis on the most effective intervention, “dosage,” or delivery channel. Finally, researchers should consistently assess and report intervention engagement, acceptability, and implementation outcomes (eg, cultural fit, sustainability, and cost-effectiveness) [76] to determine the viability of mobile technologies for behavior change and successful implementation in the MENA context.

Our systematic review and meta-analysis found that research in the MENA region on the use of mobile interventions for physical activity and sedentary behaviors is in its early stages, with preliminary evidence indicating their effectiveness. However, the studies varied greatly in terms of intervention components, methodology, and study quality, and therefore, the findings must be interpreted with caution. Policy makers and researchers need to invest in high-quality studies to evaluate the effectiveness, engagement, and implementation process of mobile interventions in the MENA region.